-- dump date 20140618_225901 -- class Genbank::misc_feature -- table misc_feature_note -- id note 527021000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 527021000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 527021000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021000004 Walker A motif; other site 527021000005 ATP binding site [chemical binding]; other site 527021000006 Walker B motif; other site 527021000007 arginine finger; other site 527021000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 527021000009 DnaA box-binding interface [nucleotide binding]; other site 527021000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 527021000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 527021000012 putative DNA binding surface [nucleotide binding]; other site 527021000013 dimer interface [polypeptide binding]; other site 527021000014 beta-clamp/clamp loader binding surface; other site 527021000015 beta-clamp/translesion DNA polymerase binding surface; other site 527021000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 527021000017 recombination protein F; Reviewed; Region: recF; PRK00064 527021000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 527021000019 Walker A/P-loop; other site 527021000020 ATP binding site [chemical binding]; other site 527021000021 Q-loop/lid; other site 527021000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021000023 ABC transporter signature motif; other site 527021000024 Walker B; other site 527021000025 D-loop; other site 527021000026 H-loop/switch region; other site 527021000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 527021000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021000029 Mg2+ binding site [ion binding]; other site 527021000030 G-X-G motif; other site 527021000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 527021000032 anchoring element; other site 527021000033 dimer interface [polypeptide binding]; other site 527021000034 ATP binding site [chemical binding]; other site 527021000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 527021000036 active site 527021000037 putative metal-binding site [ion binding]; other site 527021000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 527021000039 DNA gyrase subunit A; Validated; Region: PRK05560 527021000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 527021000041 CAP-like domain; other site 527021000042 active site 527021000043 primary dimer interface [polypeptide binding]; other site 527021000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021000050 YaaC-like Protein; Region: YaaC; pfam14175 527021000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 527021000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 527021000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 527021000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 527021000055 active site 527021000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 527021000057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 527021000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 527021000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 527021000061 active site 527021000062 multimer interface [polypeptide binding]; other site 527021000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 527021000064 predicted active site [active] 527021000065 catalytic triad [active] 527021000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 527021000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 527021000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 527021000069 dimer interface [polypeptide binding]; other site 527021000070 active site 527021000071 motif 1; other site 527021000072 motif 2; other site 527021000073 motif 3; other site 527021000074 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 527021000075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021000076 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 527021000077 DNA binding residues [nucleotide binding] 527021000078 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 527021000079 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 527021000080 Substrate-binding site [chemical binding]; other site 527021000081 Substrate specificity [chemical binding]; other site 527021000082 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 527021000083 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 527021000084 Substrate-binding site [chemical binding]; other site 527021000085 Substrate specificity [chemical binding]; other site 527021000086 Isochorismatase family; Region: Isochorismatase; pfam00857 527021000087 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 527021000088 catalytic triad [active] 527021000089 conserved cis-peptide bond; other site 527021000090 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 527021000091 nucleoside/Zn binding site; other site 527021000092 dimer interface [polypeptide binding]; other site 527021000093 catalytic motif [active] 527021000094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 527021000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021000096 Walker A motif; other site 527021000097 ATP binding site [chemical binding]; other site 527021000098 Walker B motif; other site 527021000099 arginine finger; other site 527021000100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 527021000101 hypothetical protein; Validated; Region: PRK00153 527021000102 recombination protein RecR; Reviewed; Region: recR; PRK00076 527021000103 RecR protein; Region: RecR; pfam02132 527021000104 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 527021000105 putative active site [active] 527021000106 putative metal-binding site [ion binding]; other site 527021000107 tetramer interface [polypeptide binding]; other site 527021000108 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 527021000109 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 527021000110 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 527021000111 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 527021000112 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 527021000113 homodimer interface [polypeptide binding]; other site 527021000114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021000115 catalytic residue [active] 527021000116 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 527021000117 thymidylate kinase; Validated; Region: tmk; PRK00698 527021000118 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 527021000119 TMP-binding site; other site 527021000120 ATP-binding site [chemical binding]; other site 527021000121 DNA polymerase III subunit delta'; Validated; Region: PRK08058 527021000122 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 527021000123 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 527021000124 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 527021000125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021000126 S-adenosylmethionine binding site [chemical binding]; other site 527021000127 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 527021000128 GIY-YIG motif/motif A; other site 527021000129 putative active site [active] 527021000130 putative metal binding site [ion binding]; other site 527021000131 Predicted methyltransferases [General function prediction only]; Region: COG0313 527021000132 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 527021000133 putative SAM binding site [chemical binding]; other site 527021000134 putative homodimer interface [polypeptide binding]; other site 527021000135 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 527021000136 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 527021000137 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 527021000138 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 527021000139 active site 527021000140 HIGH motif; other site 527021000141 KMSKS motif; other site 527021000142 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 527021000143 tRNA binding surface [nucleotide binding]; other site 527021000144 anticodon binding site; other site 527021000145 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 527021000146 dimer interface [polypeptide binding]; other site 527021000147 putative tRNA-binding site [nucleotide binding]; other site 527021000148 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 527021000149 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 527021000150 active site 527021000151 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 527021000152 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 527021000153 putative active site [active] 527021000154 putative metal binding site [ion binding]; other site 527021000155 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 527021000156 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 527021000157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021000158 S-adenosylmethionine binding site [chemical binding]; other site 527021000159 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 527021000160 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 527021000161 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 527021000162 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 527021000163 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 527021000164 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 527021000165 pur operon repressor; Provisional; Region: PRK09213 527021000166 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 527021000167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021000168 active site 527021000169 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 527021000170 homotrimer interaction site [polypeptide binding]; other site 527021000171 putative active site [active] 527021000172 regulatory protein SpoVG; Reviewed; Region: PRK13259 527021000173 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 527021000174 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 527021000175 Substrate binding site; other site 527021000176 Mg++ binding site; other site 527021000177 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 527021000178 active site 527021000179 substrate binding site [chemical binding]; other site 527021000180 CoA binding site [chemical binding]; other site 527021000181 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 527021000182 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 527021000183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021000184 active site 527021000185 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 527021000186 putative active site [active] 527021000187 catalytic residue [active] 527021000188 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 527021000189 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 527021000190 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 527021000191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021000192 ATP binding site [chemical binding]; other site 527021000193 putative Mg++ binding site [ion binding]; other site 527021000194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021000195 nucleotide binding region [chemical binding]; other site 527021000196 ATP-binding site [chemical binding]; other site 527021000197 TRCF domain; Region: TRCF; pfam03461 527021000198 stage V sporulation protein T; Region: spore_V_T; TIGR02851 527021000199 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 527021000200 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 527021000201 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 527021000202 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 527021000203 putative SAM binding site [chemical binding]; other site 527021000204 putative homodimer interface [polypeptide binding]; other site 527021000205 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 527021000206 homodimer interface [polypeptide binding]; other site 527021000207 metal binding site [ion binding]; metal-binding site 527021000208 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 527021000209 homodimer interface [polypeptide binding]; other site 527021000210 active site 527021000211 putative chemical substrate binding site [chemical binding]; other site 527021000212 metal binding site [ion binding]; metal-binding site 527021000213 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021000214 RNA binding surface [nucleotide binding]; other site 527021000215 sporulation protein YabP; Region: spore_yabP; TIGR02892 527021000216 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 527021000217 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 527021000218 Septum formation initiator; Region: DivIC; pfam04977 527021000219 hypothetical protein; Provisional; Region: PRK08582 527021000220 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 527021000221 RNA binding site [nucleotide binding]; other site 527021000222 stage II sporulation protein E; Region: spore_II_E; TIGR02865 527021000223 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 527021000224 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 527021000225 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 527021000226 Ligand Binding Site [chemical binding]; other site 527021000227 TilS substrate binding domain; Region: TilS; pfam09179 527021000228 TilS substrate C-terminal domain; Region: TilS_C; smart00977 527021000229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021000230 active site 527021000231 FtsH Extracellular; Region: FtsH_ext; pfam06480 527021000232 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 527021000233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021000234 Walker A motif; other site 527021000235 ATP binding site [chemical binding]; other site 527021000236 Walker B motif; other site 527021000237 arginine finger; other site 527021000238 Peptidase family M41; Region: Peptidase_M41; pfam01434 527021000239 pantothenate kinase; Reviewed; Region: PRK13318 527021000240 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 527021000241 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 527021000242 dimerization interface [polypeptide binding]; other site 527021000243 domain crossover interface; other site 527021000244 redox-dependent activation switch; other site 527021000245 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 527021000246 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 527021000247 dimer interface [polypeptide binding]; other site 527021000248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021000249 catalytic residue [active] 527021000250 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 527021000251 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 527021000252 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 527021000253 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 527021000254 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 527021000255 glutamine binding [chemical binding]; other site 527021000256 catalytic triad [active] 527021000257 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 527021000258 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 527021000259 homodimer interface [polypeptide binding]; other site 527021000260 substrate-cofactor binding pocket; other site 527021000261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021000262 catalytic residue [active] 527021000263 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 527021000264 dihydropteroate synthase; Region: DHPS; TIGR01496 527021000265 substrate binding pocket [chemical binding]; other site 527021000266 dimer interface [polypeptide binding]; other site 527021000267 inhibitor binding site; inhibition site 527021000268 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 527021000269 homooctamer interface [polypeptide binding]; other site 527021000270 active site 527021000271 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 527021000272 catalytic center binding site [active] 527021000273 ATP binding site [chemical binding]; other site 527021000274 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021000275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021000276 non-specific DNA binding site [nucleotide binding]; other site 527021000277 salt bridge; other site 527021000278 sequence-specific DNA binding site [nucleotide binding]; other site 527021000279 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 527021000280 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 527021000281 FMN binding site [chemical binding]; other site 527021000282 active site 527021000283 catalytic residues [active] 527021000284 substrate binding site [chemical binding]; other site 527021000285 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 527021000286 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 527021000287 dimer interface [polypeptide binding]; other site 527021000288 putative anticodon binding site; other site 527021000289 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 527021000290 motif 1; other site 527021000291 active site 527021000292 motif 2; other site 527021000293 motif 3; other site 527021000294 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 527021000295 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 527021000296 UvrB/uvrC motif; Region: UVR; pfam02151 527021000297 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 527021000298 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 527021000299 ADP binding site [chemical binding]; other site 527021000300 phosphagen binding site; other site 527021000301 substrate specificity loop; other site 527021000302 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 527021000303 Clp amino terminal domain; Region: Clp_N; pfam02861 527021000304 Clp amino terminal domain; Region: Clp_N; pfam02861 527021000305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021000306 Walker A motif; other site 527021000307 ATP binding site [chemical binding]; other site 527021000308 Walker B motif; other site 527021000309 arginine finger; other site 527021000310 UvrB/uvrC motif; Region: UVR; pfam02151 527021000311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021000312 Walker A motif; other site 527021000313 ATP binding site [chemical binding]; other site 527021000314 Walker B motif; other site 527021000315 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 527021000316 DNA repair protein RadA; Provisional; Region: PRK11823 527021000317 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 527021000318 Walker A motif/ATP binding site; other site 527021000319 ATP binding site [chemical binding]; other site 527021000320 Walker B motif; other site 527021000321 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 527021000322 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 527021000323 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 527021000324 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 527021000325 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 527021000326 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 527021000327 putative active site [active] 527021000328 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 527021000329 substrate binding site; other site 527021000330 dimer interface; other site 527021000331 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 527021000332 homotrimer interaction site [polypeptide binding]; other site 527021000333 zinc binding site [ion binding]; other site 527021000334 CDP-binding sites; other site 527021000335 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 527021000336 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 527021000337 HIGH motif; other site 527021000338 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 527021000339 active site 527021000340 KMSKS motif; other site 527021000341 serine O-acetyltransferase; Region: cysE; TIGR01172 527021000342 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 527021000343 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 527021000344 trimer interface [polypeptide binding]; other site 527021000345 active site 527021000346 substrate binding site [chemical binding]; other site 527021000347 CoA binding site [chemical binding]; other site 527021000348 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 527021000349 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 527021000350 active site 527021000351 HIGH motif; other site 527021000352 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 527021000353 KMSKS motif; other site 527021000354 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 527021000355 tRNA binding surface [nucleotide binding]; other site 527021000356 anticodon binding site; other site 527021000357 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 527021000358 active site 527021000359 metal binding site [ion binding]; metal-binding site 527021000360 dimerization interface [polypeptide binding]; other site 527021000361 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 527021000362 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 527021000363 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 527021000364 YacP-like NYN domain; Region: NYN_YacP; pfam05991 527021000365 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 527021000366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021000367 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 527021000368 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 527021000369 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 527021000370 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 527021000371 putative homodimer interface [polypeptide binding]; other site 527021000372 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 527021000373 heterodimer interface [polypeptide binding]; other site 527021000374 homodimer interface [polypeptide binding]; other site 527021000375 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 527021000376 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 527021000377 23S rRNA interface [nucleotide binding]; other site 527021000378 L7/L12 interface [polypeptide binding]; other site 527021000379 putative thiostrepton binding site; other site 527021000380 L25 interface [polypeptide binding]; other site 527021000381 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 527021000382 mRNA/rRNA interface [nucleotide binding]; other site 527021000383 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 527021000384 23S rRNA interface [nucleotide binding]; other site 527021000385 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 527021000386 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 527021000387 core dimer interface [polypeptide binding]; other site 527021000388 peripheral dimer interface [polypeptide binding]; other site 527021000389 L10 interface [polypeptide binding]; other site 527021000390 L11 interface [polypeptide binding]; other site 527021000391 putative EF-Tu interaction site [polypeptide binding]; other site 527021000392 putative EF-G interaction site [polypeptide binding]; other site 527021000393 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 527021000394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021000395 S-adenosylmethionine binding site [chemical binding]; other site 527021000396 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 527021000397 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 527021000398 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 527021000399 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 527021000400 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 527021000401 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 527021000402 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 527021000403 RPB10 interaction site [polypeptide binding]; other site 527021000404 RPB1 interaction site [polypeptide binding]; other site 527021000405 RPB11 interaction site [polypeptide binding]; other site 527021000406 RPB3 interaction site [polypeptide binding]; other site 527021000407 RPB12 interaction site [polypeptide binding]; other site 527021000408 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 527021000409 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 527021000410 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 527021000411 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 527021000412 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 527021000413 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 527021000414 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 527021000415 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 527021000416 G-loop; other site 527021000417 DNA binding site [nucleotide binding] 527021000418 hypothetical protein; Provisional; Region: PRK06683 527021000419 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 527021000420 S17 interaction site [polypeptide binding]; other site 527021000421 S8 interaction site; other site 527021000422 16S rRNA interaction site [nucleotide binding]; other site 527021000423 streptomycin interaction site [chemical binding]; other site 527021000424 23S rRNA interaction site [nucleotide binding]; other site 527021000425 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 527021000426 30S ribosomal protein S7; Validated; Region: PRK05302 527021000427 elongation factor G; Reviewed; Region: PRK00007 527021000428 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 527021000429 G1 box; other site 527021000430 putative GEF interaction site [polypeptide binding]; other site 527021000431 GTP/Mg2+ binding site [chemical binding]; other site 527021000432 Switch I region; other site 527021000433 G2 box; other site 527021000434 G3 box; other site 527021000435 Switch II region; other site 527021000436 G4 box; other site 527021000437 G5 box; other site 527021000438 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 527021000439 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 527021000440 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 527021000441 elongation factor Tu; Reviewed; Region: PRK00049 527021000442 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 527021000443 G1 box; other site 527021000444 GEF interaction site [polypeptide binding]; other site 527021000445 GTP/Mg2+ binding site [chemical binding]; other site 527021000446 Switch I region; other site 527021000447 G2 box; other site 527021000448 G3 box; other site 527021000449 Switch II region; other site 527021000450 G4 box; other site 527021000451 G5 box; other site 527021000452 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 527021000453 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 527021000454 Antibiotic Binding Site [chemical binding]; other site 527021000455 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 527021000456 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 527021000457 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 527021000458 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 527021000459 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 527021000460 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 527021000461 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 527021000462 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 527021000463 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 527021000464 putative translocon binding site; other site 527021000465 protein-rRNA interface [nucleotide binding]; other site 527021000466 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 527021000467 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 527021000468 G-X-X-G motif; other site 527021000469 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 527021000470 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 527021000471 23S rRNA interface [nucleotide binding]; other site 527021000472 5S rRNA interface [nucleotide binding]; other site 527021000473 putative antibiotic binding site [chemical binding]; other site 527021000474 L25 interface [polypeptide binding]; other site 527021000475 L27 interface [polypeptide binding]; other site 527021000476 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 527021000477 23S rRNA interface [nucleotide binding]; other site 527021000478 putative translocon interaction site; other site 527021000479 signal recognition particle (SRP54) interaction site; other site 527021000480 L23 interface [polypeptide binding]; other site 527021000481 trigger factor interaction site; other site 527021000482 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 527021000483 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 527021000484 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 527021000485 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 527021000486 RNA binding site [nucleotide binding]; other site 527021000487 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 527021000488 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 527021000489 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 527021000490 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 527021000491 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 527021000492 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 527021000493 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 527021000494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 527021000495 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 527021000496 5S rRNA interface [nucleotide binding]; other site 527021000497 L27 interface [polypeptide binding]; other site 527021000498 23S rRNA interface [nucleotide binding]; other site 527021000499 L5 interface [polypeptide binding]; other site 527021000500 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 527021000501 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 527021000502 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 527021000503 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 527021000504 23S rRNA binding site [nucleotide binding]; other site 527021000505 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 527021000506 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 527021000507 SecY translocase; Region: SecY; pfam00344 527021000508 adenylate kinase; Reviewed; Region: adk; PRK00279 527021000509 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 527021000510 AMP-binding site [chemical binding]; other site 527021000511 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 527021000512 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 527021000513 active site 527021000514 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 527021000515 rRNA binding site [nucleotide binding]; other site 527021000516 predicted 30S ribosome binding site; other site 527021000517 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 527021000518 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 527021000519 30S ribosomal protein S13; Region: bact_S13; TIGR03631 527021000520 30S ribosomal protein S11; Validated; Region: PRK05309 527021000521 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 527021000522 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 527021000523 alphaNTD - beta interaction site [polypeptide binding]; other site 527021000524 alphaNTD homodimer interface [polypeptide binding]; other site 527021000525 alphaNTD - beta' interaction site [polypeptide binding]; other site 527021000526 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 527021000527 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 527021000528 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 527021000529 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 527021000530 Walker A/P-loop; other site 527021000531 ATP binding site [chemical binding]; other site 527021000532 Q-loop/lid; other site 527021000533 ABC transporter signature motif; other site 527021000534 Walker B; other site 527021000535 D-loop; other site 527021000536 H-loop/switch region; other site 527021000537 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 527021000538 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 527021000539 Walker A/P-loop; other site 527021000540 ATP binding site [chemical binding]; other site 527021000541 Q-loop/lid; other site 527021000542 ABC transporter signature motif; other site 527021000543 Walker B; other site 527021000544 D-loop; other site 527021000545 H-loop/switch region; other site 527021000546 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 527021000547 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 527021000548 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 527021000549 dimerization interface 3.5A [polypeptide binding]; other site 527021000550 active site 527021000551 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 527021000552 23S rRNA interface [nucleotide binding]; other site 527021000553 L3 interface [polypeptide binding]; other site 527021000554 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 527021000555 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 527021000556 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 527021000557 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 527021000558 active site 527021000559 metal binding site [ion binding]; metal-binding site 527021000560 Domain of unknown function DUF59; Region: DUF59; cl00941 527021000561 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 527021000562 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 527021000563 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 527021000564 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 527021000565 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 527021000566 NodB motif; other site 527021000567 putative active site [active] 527021000568 putative catalytic site [active] 527021000569 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 527021000570 Arginase family; Region: Arginase; cd09989 527021000571 agmatinase; Region: agmatinase; TIGR01230 527021000572 active site 527021000573 Mn binding site [ion binding]; other site 527021000574 oligomer interface [polypeptide binding]; other site 527021000575 Uncharacterized conserved protein [Function unknown]; Region: COG1624 527021000576 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 527021000577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 527021000578 YbbR-like protein; Region: YbbR; pfam07949 527021000579 YbbR-like protein; Region: YbbR; pfam07949 527021000580 YbbR-like protein; Region: YbbR; pfam07949 527021000581 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 527021000582 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 527021000583 active site 527021000584 substrate binding site [chemical binding]; other site 527021000585 metal binding site [ion binding]; metal-binding site 527021000586 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 527021000587 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 527021000588 glutaminase active site [active] 527021000589 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 527021000590 dimer interface [polypeptide binding]; other site 527021000591 active site 527021000592 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 527021000593 dimer interface [polypeptide binding]; other site 527021000594 active site 527021000595 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 527021000596 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 527021000597 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 527021000598 Predicted membrane protein [Function unknown]; Region: COG2259 527021000599 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 527021000600 classical (c) SDRs; Region: SDR_c; cd05233 527021000601 NAD(P) binding site [chemical binding]; other site 527021000602 active site 527021000603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021000604 ABC-ATPase subunit interface; other site 527021000605 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 527021000606 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 527021000607 Walker A/P-loop; other site 527021000608 ATP binding site [chemical binding]; other site 527021000609 Q-loop/lid; other site 527021000610 ABC transporter signature motif; other site 527021000611 Walker B; other site 527021000612 D-loop; other site 527021000613 H-loop/switch region; other site 527021000614 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 527021000615 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 527021000616 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 527021000617 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 527021000618 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 527021000619 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 527021000620 putative NAD(P) binding site [chemical binding]; other site 527021000621 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 527021000622 FAD binding domain; Region: FAD_binding_4; pfam01565 527021000623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021000624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021000625 putative substrate translocation pore; other site 527021000626 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 527021000627 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 527021000628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021000629 putative substrate translocation pore; other site 527021000630 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 527021000631 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 527021000632 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 527021000633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021000634 dimer interface [polypeptide binding]; other site 527021000635 conserved gate region; other site 527021000636 putative PBP binding loops; other site 527021000637 ABC-ATPase subunit interface; other site 527021000638 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 527021000639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021000640 dimer interface [polypeptide binding]; other site 527021000641 conserved gate region; other site 527021000642 putative PBP binding loops; other site 527021000643 ABC-ATPase subunit interface; other site 527021000644 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 527021000645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021000646 Walker A/P-loop; other site 527021000647 ATP binding site [chemical binding]; other site 527021000648 Q-loop/lid; other site 527021000649 ABC transporter signature motif; other site 527021000650 Walker B; other site 527021000651 D-loop; other site 527021000652 H-loop/switch region; other site 527021000653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 527021000654 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 527021000655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021000656 Walker A/P-loop; other site 527021000657 ATP binding site [chemical binding]; other site 527021000658 Q-loop/lid; other site 527021000659 ABC transporter signature motif; other site 527021000660 Walker B; other site 527021000661 D-loop; other site 527021000662 H-loop/switch region; other site 527021000663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 527021000664 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021000665 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021000666 peptide binding site [polypeptide binding]; other site 527021000667 YusW-like protein; Region: YusW; pfam14039 527021000668 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021000669 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021000670 peptide binding site [polypeptide binding]; other site 527021000671 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021000672 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021000673 peptide binding site [polypeptide binding]; other site 527021000674 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 527021000675 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 527021000676 active site 527021000677 catalytic tetrad [active] 527021000678 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 527021000679 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 527021000680 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 527021000681 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 527021000682 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 527021000683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021000684 dimer interface [polypeptide binding]; other site 527021000685 conserved gate region; other site 527021000686 putative PBP binding loops; other site 527021000687 ABC-ATPase subunit interface; other site 527021000688 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 527021000689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 527021000690 dimerization interface [polypeptide binding]; other site 527021000691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 527021000692 membrane-bound complex binding site; other site 527021000693 hinge residues; other site 527021000694 DNA binding domain, excisionase family; Region: excise; TIGR01764 527021000695 PBP superfamily domain; Region: PBP_like; pfam12727 527021000696 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 527021000697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021000698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021000699 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 527021000700 putative dimerization interface [polypeptide binding]; other site 527021000701 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021000702 EamA-like transporter family; Region: EamA; pfam00892 527021000703 YrzO-like protein; Region: YrzO; pfam14142 527021000704 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 527021000705 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 527021000706 putative acyl-acceptor binding pocket; other site 527021000707 Transcriptional regulators [Transcription]; Region: PurR; COG1609 527021000708 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 527021000709 DNA binding site [nucleotide binding] 527021000710 domain linker motif; other site 527021000711 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 527021000712 putative ligand binding site [chemical binding]; other site 527021000713 putative dimerization interface [polypeptide binding]; other site 527021000714 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021000715 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021000716 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021000717 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021000718 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 527021000719 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 527021000720 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 527021000721 active site 527021000722 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 527021000723 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 527021000724 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 527021000725 N-acetyl-D-glucosamine binding site [chemical binding]; other site 527021000726 catalytic residue [active] 527021000727 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 527021000728 nucleotide binding site/active site [active] 527021000729 HIT family signature motif; other site 527021000730 catalytic residue [active] 527021000731 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 527021000732 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021000733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021000734 ABC transporter; Region: ABC_tran_2; pfam12848 527021000735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021000736 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 527021000737 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 527021000738 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 527021000739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021000740 dimer interface [polypeptide binding]; other site 527021000741 conserved gate region; other site 527021000742 putative PBP binding loops; other site 527021000743 ABC-ATPase subunit interface; other site 527021000744 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 527021000745 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 527021000746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021000747 dimer interface [polypeptide binding]; other site 527021000748 conserved gate region; other site 527021000749 putative PBP binding loops; other site 527021000750 ABC-ATPase subunit interface; other site 527021000751 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 527021000752 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021000753 Walker A/P-loop; other site 527021000754 ATP binding site [chemical binding]; other site 527021000755 Q-loop/lid; other site 527021000756 ABC transporter signature motif; other site 527021000757 Walker B; other site 527021000758 D-loop; other site 527021000759 H-loop/switch region; other site 527021000760 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 527021000761 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 527021000762 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021000763 Walker A/P-loop; other site 527021000764 ATP binding site [chemical binding]; other site 527021000765 Q-loop/lid; other site 527021000766 ABC transporter signature motif; other site 527021000767 Walker B; other site 527021000768 D-loop; other site 527021000769 H-loop/switch region; other site 527021000770 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 527021000771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021000772 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 527021000773 active site 527021000774 motif I; other site 527021000775 motif II; other site 527021000776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021000777 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 527021000778 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 527021000779 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 527021000780 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 527021000781 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 527021000782 dimer interface [polypeptide binding]; other site 527021000783 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 527021000784 active site 527021000785 Fe binding site [ion binding]; other site 527021000786 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 527021000787 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 527021000788 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 527021000789 amino acid transporter; Region: 2A0306; TIGR00909 527021000790 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 527021000791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021000792 putative substrate translocation pore; other site 527021000793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021000794 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 527021000795 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 527021000796 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 527021000797 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 527021000798 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 527021000799 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 527021000800 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 527021000801 helicase 45; Provisional; Region: PTZ00424 527021000802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 527021000803 ATP binding site [chemical binding]; other site 527021000804 Mg++ binding site [ion binding]; other site 527021000805 motif III; other site 527021000806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021000807 nucleotide binding region [chemical binding]; other site 527021000808 ATP-binding site [chemical binding]; other site 527021000809 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 527021000810 Rhomboid family; Region: Rhomboid; pfam01694 527021000811 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 527021000812 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 527021000813 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 527021000814 alanine racemase; Reviewed; Region: alr; PRK00053 527021000815 active site 527021000816 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 527021000817 dimer interface [polypeptide binding]; other site 527021000818 substrate binding site [chemical binding]; other site 527021000819 catalytic residues [active] 527021000820 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 527021000821 PemK-like protein; Region: PemK; pfam02452 527021000822 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 527021000823 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 527021000824 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 527021000825 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 527021000826 RNA binding site [nucleotide binding]; other site 527021000827 hypothetical protein; Provisional; Region: PRK04351 527021000828 SprT homologues; Region: SprT; cl01182 527021000829 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 527021000830 Glycoprotease family; Region: Peptidase_M22; pfam00814 527021000831 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 527021000832 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 527021000833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021000834 Coenzyme A binding pocket [chemical binding]; other site 527021000835 UGMP family protein; Validated; Region: PRK09604 527021000836 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 527021000837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 527021000838 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 527021000839 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021000840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021000841 ABC transporter; Region: ABC_tran_2; pfam12848 527021000842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021000843 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 527021000844 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 527021000845 CoA binding domain; Region: CoA_binding; pfam02629 527021000846 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 527021000847 CAAX protease self-immunity; Region: Abi; pfam02517 527021000848 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 527021000849 oligomerisation interface [polypeptide binding]; other site 527021000850 mobile loop; other site 527021000851 roof hairpin; other site 527021000852 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 527021000853 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 527021000854 ring oligomerisation interface [polypeptide binding]; other site 527021000855 ATP/Mg binding site [chemical binding]; other site 527021000856 stacking interactions; other site 527021000857 hinge regions; other site 527021000858 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 527021000859 Uncharacterized conserved protein [Function unknown]; Region: COG5444 527021000860 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 527021000861 GMP synthase; Reviewed; Region: guaA; PRK00074 527021000862 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 527021000863 AMP/PPi binding site [chemical binding]; other site 527021000864 candidate oxyanion hole; other site 527021000865 catalytic triad [active] 527021000866 potential glutamine specificity residues [chemical binding]; other site 527021000867 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 527021000868 ATP Binding subdomain [chemical binding]; other site 527021000869 Ligand Binding sites [chemical binding]; other site 527021000870 Dimerization subdomain; other site 527021000871 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 527021000872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021000873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021000874 active site 527021000875 phosphorylation site [posttranslational modification] 527021000876 intermolecular recognition site; other site 527021000877 dimerization interface [polypeptide binding]; other site 527021000878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021000879 DNA binding site [nucleotide binding] 527021000880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021000881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021000882 dimerization interface [polypeptide binding]; other site 527021000883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021000884 dimer interface [polypeptide binding]; other site 527021000885 phosphorylation site [posttranslational modification] 527021000886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021000887 ATP binding site [chemical binding]; other site 527021000888 Mg2+ binding site [ion binding]; other site 527021000889 G-X-G motif; other site 527021000890 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 527021000891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021000892 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 527021000893 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 527021000894 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 527021000895 catalytic residues [active] 527021000896 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021000897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021000898 DNA-binding site [nucleotide binding]; DNA binding site 527021000899 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021000900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021000901 homodimer interface [polypeptide binding]; other site 527021000902 catalytic residue [active] 527021000903 Proline dehydrogenase; Region: Pro_dh; cl03282 527021000904 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 527021000905 putative catalytic site [active] 527021000906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 527021000907 Integrase core domain; Region: rve; pfam00665 527021000908 transposase/IS protein; Provisional; Region: PRK09183 527021000909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021000910 Walker A motif; other site 527021000911 ATP binding site [chemical binding]; other site 527021000912 Walker B motif; other site 527021000913 arginine finger; other site 527021000914 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 527021000915 putative ligand binding site [chemical binding]; other site 527021000916 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021000917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021000918 S-adenosylmethionine binding site [chemical binding]; other site 527021000919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021000920 S-adenosylmethionine binding site [chemical binding]; other site 527021000921 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 527021000922 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 527021000923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021000924 NAD(P) binding site [chemical binding]; other site 527021000925 active site 527021000926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021000927 S-adenosylmethionine binding site [chemical binding]; other site 527021000928 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 527021000929 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 527021000930 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 527021000931 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 527021000932 active site 527021000933 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021000934 EamA-like transporter family; Region: EamA; pfam00892 527021000935 EamA-like transporter family; Region: EamA; pfam00892 527021000936 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 527021000937 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 527021000938 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 527021000939 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 527021000940 NAD binding site [chemical binding]; other site 527021000941 ATP-grasp domain; Region: ATP-grasp; pfam02222 527021000942 adenylosuccinate lyase; Provisional; Region: PRK07492 527021000943 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 527021000944 tetramer interface [polypeptide binding]; other site 527021000945 active site 527021000946 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 527021000947 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 527021000948 ATP binding site [chemical binding]; other site 527021000949 active site 527021000950 substrate binding site [chemical binding]; other site 527021000951 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 527021000952 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 527021000953 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 527021000954 putative active site [active] 527021000955 catalytic triad [active] 527021000956 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 527021000957 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 527021000958 dimerization interface [polypeptide binding]; other site 527021000959 ATP binding site [chemical binding]; other site 527021000960 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 527021000961 dimerization interface [polypeptide binding]; other site 527021000962 ATP binding site [chemical binding]; other site 527021000963 amidophosphoribosyltransferase; Provisional; Region: PRK06781 527021000964 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 527021000965 active site 527021000966 tetramer interface [polypeptide binding]; other site 527021000967 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021000968 active site 527021000969 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 527021000970 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 527021000971 dimerization interface [polypeptide binding]; other site 527021000972 putative ATP binding site [chemical binding]; other site 527021000973 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 527021000974 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 527021000975 active site 527021000976 substrate binding site [chemical binding]; other site 527021000977 cosubstrate binding site; other site 527021000978 catalytic site [active] 527021000979 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 527021000980 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 527021000981 purine monophosphate binding site [chemical binding]; other site 527021000982 dimer interface [polypeptide binding]; other site 527021000983 putative catalytic residues [active] 527021000984 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 527021000985 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 527021000986 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 527021000987 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 527021000988 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 527021000989 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 527021000990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021000991 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021000992 putative substrate translocation pore; other site 527021000993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021000994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021000995 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 527021000996 putative dimerization interface [polypeptide binding]; other site 527021000997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 527021000998 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 527021000999 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 527021001000 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 527021001001 PcrB family; Region: PcrB; pfam01884 527021001002 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 527021001003 substrate binding site [chemical binding]; other site 527021001004 putative active site [active] 527021001005 dimer interface [polypeptide binding]; other site 527021001006 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 527021001007 Part of AAA domain; Region: AAA_19; pfam13245 527021001008 Family description; Region: UvrD_C_2; pfam13538 527021001009 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 527021001010 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 527021001011 nucleotide binding pocket [chemical binding]; other site 527021001012 K-X-D-G motif; other site 527021001013 catalytic site [active] 527021001014 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 527021001015 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 527021001016 Dimer interface [polypeptide binding]; other site 527021001017 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 527021001018 putative dimer interface [polypeptide binding]; other site 527021001019 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 527021001020 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 527021001021 putative dimer interface [polypeptide binding]; other site 527021001022 hypothetical protein; Provisional; Region: PRK10621 527021001023 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 527021001024 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 527021001025 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 527021001026 Glutamate binding site [chemical binding]; other site 527021001027 homodimer interface [polypeptide binding]; other site 527021001028 NAD binding site [chemical binding]; other site 527021001029 catalytic residues [active] 527021001030 Isochorismatase family; Region: Isochorismatase; pfam00857 527021001031 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 527021001032 catalytic triad [active] 527021001033 conserved cis-peptide bond; other site 527021001034 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 527021001035 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 527021001036 Walker A/P-loop; other site 527021001037 ATP binding site [chemical binding]; other site 527021001038 Q-loop/lid; other site 527021001039 ABC transporter signature motif; other site 527021001040 Walker B; other site 527021001041 D-loop; other site 527021001042 H-loop/switch region; other site 527021001043 NIL domain; Region: NIL; pfam09383 527021001044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021001045 dimer interface [polypeptide binding]; other site 527021001046 conserved gate region; other site 527021001047 ABC-ATPase subunit interface; other site 527021001048 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 527021001049 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 527021001050 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 527021001051 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 527021001052 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 527021001053 P loop; other site 527021001054 Nucleotide binding site [chemical binding]; other site 527021001055 DTAP/Switch II; other site 527021001056 Switch I; other site 527021001057 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 527021001058 putative dimer interface [polypeptide binding]; other site 527021001059 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021001060 MarR family; Region: MarR; pfam01047 527021001061 MarR family; Region: MarR_2; cl17246 527021001062 yiaA/B two helix domain; Region: YiaAB; pfam05360 527021001063 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 527021001064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 527021001065 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 527021001066 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 527021001067 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 527021001068 GatB domain; Region: GatB_Yqey; pfam02637 527021001069 putative lipid kinase; Reviewed; Region: PRK13337 527021001070 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 527021001071 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 527021001072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021001073 motif II; other site 527021001074 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 527021001075 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 527021001076 inhibitor-cofactor binding pocket; inhibition site 527021001077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021001078 catalytic residue [active] 527021001079 PAS domain; Region: PAS_9; pfam13426 527021001080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021001081 putative active site [active] 527021001082 heme pocket [chemical binding]; other site 527021001083 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 527021001084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021001085 Walker A motif; other site 527021001086 ATP binding site [chemical binding]; other site 527021001087 Walker B motif; other site 527021001088 arginine finger; other site 527021001089 succinic semialdehyde dehydrogenase; Region: PLN02278 527021001090 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 527021001091 tetramerization interface [polypeptide binding]; other site 527021001092 NAD(P) binding site [chemical binding]; other site 527021001093 catalytic residues [active] 527021001094 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 527021001095 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 527021001096 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 527021001097 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 527021001098 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 527021001099 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 527021001100 putative active site [active] 527021001101 putative metal binding site [ion binding]; other site 527021001102 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 527021001103 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 527021001104 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 527021001105 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 527021001106 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 527021001107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021001108 S-adenosylmethionine binding site [chemical binding]; other site 527021001109 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 527021001110 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 527021001111 FMN binding site [chemical binding]; other site 527021001112 active site 527021001113 catalytic residues [active] 527021001114 substrate binding site [chemical binding]; other site 527021001115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 527021001116 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 527021001117 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 527021001118 Protein of unknown function DUF45; Region: DUF45; pfam01863 527021001119 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 527021001120 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 527021001121 active site 527021001122 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 527021001123 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 527021001124 amidohydrolase; Region: amidohydrolases; TIGR01891 527021001125 metal binding site [ion binding]; metal-binding site 527021001126 putative dimer interface [polypeptide binding]; other site 527021001127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021001128 S-adenosylmethionine binding site [chemical binding]; other site 527021001129 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 527021001130 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 527021001131 catalytic residue [active] 527021001132 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 527021001133 catalytic residues [active] 527021001134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 527021001135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021001136 peroxiredoxin; Region: AhpC; TIGR03137 527021001137 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 527021001138 dimer interface [polypeptide binding]; other site 527021001139 decamer (pentamer of dimers) interface [polypeptide binding]; other site 527021001140 catalytic triad [active] 527021001141 peroxidatic and resolving cysteines [active] 527021001142 5-methylribose kinase; Reviewed; Region: PRK12396 527021001143 Phosphotransferase enzyme family; Region: APH; pfam01636 527021001144 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 527021001145 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 527021001146 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 527021001147 intersubunit interface [polypeptide binding]; other site 527021001148 active site 527021001149 Zn2+ binding site [ion binding]; other site 527021001150 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 527021001151 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021001152 ABC-ATPase subunit interface; other site 527021001153 dimer interface [polypeptide binding]; other site 527021001154 putative PBP binding regions; other site 527021001155 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 527021001156 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021001157 ABC-ATPase subunit interface; other site 527021001158 dimer interface [polypeptide binding]; other site 527021001159 putative PBP binding regions; other site 527021001160 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 527021001161 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 527021001162 putative ligand binding residues [chemical binding]; other site 527021001163 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 527021001164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 527021001165 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 527021001166 DNA binding domain, excisionase family; Region: excise; TIGR01764 527021001167 Sm and related proteins; Region: Sm_like; cl00259 527021001168 Sm1 motif; other site 527021001169 RNA binding site [nucleotide binding]; other site 527021001170 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 527021001171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021001172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021001173 dimer interface [polypeptide binding]; other site 527021001174 phosphorylation site [posttranslational modification] 527021001175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021001176 ATP binding site [chemical binding]; other site 527021001177 Mg2+ binding site [ion binding]; other site 527021001178 G-X-G motif; other site 527021001179 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 527021001180 hypothetical protein; Provisional; Region: PRK06851 527021001181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021001182 Walker A motif; other site 527021001183 ATP binding site [chemical binding]; other site 527021001184 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 527021001185 benzoate transport; Region: 2A0115; TIGR00895 527021001186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021001187 putative substrate translocation pore; other site 527021001188 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 527021001189 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 527021001190 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 527021001191 [2Fe-2S] cluster binding site [ion binding]; other site 527021001192 Fatty acid desaturase; Region: FA_desaturase; pfam00487 527021001193 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 527021001194 putative di-iron ligands [ion binding]; other site 527021001195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021001196 dimer interface [polypeptide binding]; other site 527021001197 conserved gate region; other site 527021001198 putative PBP binding loops; other site 527021001199 ABC-ATPase subunit interface; other site 527021001200 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 527021001201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 527021001202 substrate binding pocket [chemical binding]; other site 527021001203 membrane-bound complex binding site; other site 527021001204 hinge residues; other site 527021001205 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 527021001206 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 527021001207 Walker A/P-loop; other site 527021001208 ATP binding site [chemical binding]; other site 527021001209 Q-loop/lid; other site 527021001210 ABC transporter signature motif; other site 527021001211 Walker B; other site 527021001212 D-loop; other site 527021001213 H-loop/switch region; other site 527021001214 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 527021001215 HAMP domain; Region: HAMP; pfam00672 527021001216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021001217 dimer interface [polypeptide binding]; other site 527021001218 putative CheW interface [polypeptide binding]; other site 527021001219 Arginine repressor [Transcription]; Region: ArgR; COG1438 527021001220 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 527021001221 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 527021001222 arginine deiminase; Provisional; Region: PRK01388 527021001223 ornithine carbamoyltransferase; Validated; Region: PRK02102 527021001224 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 527021001225 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 527021001226 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 527021001227 carbamate kinase; Reviewed; Region: PRK12686 527021001228 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 527021001229 putative substrate binding site [chemical binding]; other site 527021001230 nucleotide binding site [chemical binding]; other site 527021001231 nucleotide binding site [chemical binding]; other site 527021001232 homodimer interface [polypeptide binding]; other site 527021001233 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 527021001234 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 527021001235 ligand binding site [chemical binding]; other site 527021001236 flexible hinge region; other site 527021001237 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 527021001238 putative switch regulator; other site 527021001239 non-specific DNA interactions [nucleotide binding]; other site 527021001240 DNA binding site [nucleotide binding] 527021001241 sequence specific DNA binding site [nucleotide binding]; other site 527021001242 putative cAMP binding site [chemical binding]; other site 527021001243 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 527021001244 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 527021001245 FAD binding domain; Region: FAD_binding_4; pfam01565 527021001246 Berberine and berberine like; Region: BBE; pfam08031 527021001247 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 527021001248 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 527021001249 Ca binding site [ion binding]; other site 527021001250 active site 527021001251 catalytic site [active] 527021001252 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 527021001253 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 527021001254 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 527021001255 active site turn [active] 527021001256 phosphorylation site [posttranslational modification] 527021001257 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 527021001258 putative catalytic site [active] 527021001259 putative metal binding site [ion binding]; other site 527021001260 putative phosphate binding site [ion binding]; other site 527021001261 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 527021001262 Predicted membrane protein [Function unknown]; Region: COG1511 527021001263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021001264 DNA topoisomerase III; Provisional; Region: PRK07726 527021001265 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 527021001266 active site 527021001267 putative interdomain interaction site [polypeptide binding]; other site 527021001268 putative metal-binding site [ion binding]; other site 527021001269 putative nucleotide binding site [chemical binding]; other site 527021001270 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 527021001271 domain I; other site 527021001272 DNA binding groove [nucleotide binding] 527021001273 phosphate binding site [ion binding]; other site 527021001274 domain II; other site 527021001275 domain III; other site 527021001276 nucleotide binding site [chemical binding]; other site 527021001277 catalytic site [active] 527021001278 domain IV; other site 527021001279 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 527021001280 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 527021001281 substrate binding site [chemical binding]; other site 527021001282 multimerization interface [polypeptide binding]; other site 527021001283 ATP binding site [chemical binding]; other site 527021001284 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 527021001285 thiamine phosphate binding site [chemical binding]; other site 527021001286 active site 527021001287 pyrophosphate binding site [ion binding]; other site 527021001288 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 527021001289 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 527021001290 HAMP domain; Region: HAMP; pfam00672 527021001291 dimerization interface [polypeptide binding]; other site 527021001292 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021001293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021001294 dimer interface [polypeptide binding]; other site 527021001295 putative CheW interface [polypeptide binding]; other site 527021001296 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 527021001297 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 527021001298 acyl-activating enzyme (AAE) consensus motif; other site 527021001299 AMP binding site [chemical binding]; other site 527021001300 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021001301 thioester reductase domain; Region: Thioester-redct; TIGR01746 527021001302 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 527021001303 putative NAD(P) binding site [chemical binding]; other site 527021001304 active site 527021001305 putative substrate binding site [chemical binding]; other site 527021001306 Domain of unknown function DUF77; Region: DUF77; pfam01910 527021001307 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 527021001308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021001309 dimer interface [polypeptide binding]; other site 527021001310 conserved gate region; other site 527021001311 putative PBP binding loops; other site 527021001312 ABC-ATPase subunit interface; other site 527021001313 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 527021001314 NMT1/THI5 like; Region: NMT1; pfam09084 527021001315 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 527021001316 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 527021001317 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 527021001318 Walker A/P-loop; other site 527021001319 ATP binding site [chemical binding]; other site 527021001320 Q-loop/lid; other site 527021001321 ABC transporter signature motif; other site 527021001322 Walker B; other site 527021001323 D-loop; other site 527021001324 H-loop/switch region; other site 527021001325 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 527021001326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021001327 Walker A/P-loop; other site 527021001328 ATP binding site [chemical binding]; other site 527021001329 Q-loop/lid; other site 527021001330 ABC transporter signature motif; other site 527021001331 Walker B; other site 527021001332 D-loop; other site 527021001333 H-loop/switch region; other site 527021001334 ABC transporter; Region: ABC_tran_2; pfam12848 527021001335 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021001336 Glyco_18 domain; Region: Glyco_18; smart00636 527021001337 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 527021001338 active site 527021001339 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 527021001340 Interdomain contacts; other site 527021001341 Cytokine receptor motif; other site 527021001342 Cellulose binding domain; Region: CBM_2; pfam00553 527021001343 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 527021001344 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 527021001345 catalytic residues [active] 527021001346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021001347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021001348 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 527021001349 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021001350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021001351 putative substrate translocation pore; other site 527021001352 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021001353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021001354 non-specific DNA binding site [nucleotide binding]; other site 527021001355 salt bridge; other site 527021001356 sequence-specific DNA binding site [nucleotide binding]; other site 527021001357 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 527021001358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021001359 putative substrate translocation pore; other site 527021001360 Uncharacterized conserved protein [Function unknown]; Region: COG3379 527021001361 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 527021001362 YesK-like protein; Region: YesK; pfam14150 527021001363 prolyl-tRNA synthetase; Provisional; Region: PRK08661 527021001364 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 527021001365 dimer interface [polypeptide binding]; other site 527021001366 motif 1; other site 527021001367 active site 527021001368 motif 2; other site 527021001369 motif 3; other site 527021001370 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 527021001371 anticodon binding site; other site 527021001372 zinc-binding site [ion binding]; other site 527021001373 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 527021001374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 527021001375 nucleotide binding site [chemical binding]; other site 527021001376 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 527021001377 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 527021001378 putative metal binding site [ion binding]; other site 527021001379 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 527021001380 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 527021001381 putative metal binding site [ion binding]; other site 527021001382 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 527021001383 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 527021001384 putative metal binding site [ion binding]; other site 527021001385 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 527021001386 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 527021001387 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 527021001388 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 527021001389 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 527021001390 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 527021001391 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 527021001392 Soluble P-type ATPase [General function prediction only]; Region: COG4087 527021001393 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 527021001394 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 527021001395 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 527021001396 Low molecular weight phosphatase family; Region: LMWPc; cd00115 527021001397 active site 527021001398 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 527021001399 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 527021001400 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 527021001401 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 527021001402 Soluble P-type ATPase [General function prediction only]; Region: COG4087 527021001403 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021001404 EamA-like transporter family; Region: EamA; pfam00892 527021001405 EamA-like transporter family; Region: EamA; pfam00892 527021001406 YhhN-like protein; Region: YhhN; pfam07947 527021001407 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 527021001408 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021001409 Catalytic site [active] 527021001410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021001411 binding surface 527021001412 TPR motif; other site 527021001413 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 527021001414 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 527021001415 Predicted membrane protein [Function unknown]; Region: COG2510 527021001416 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 527021001417 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 527021001418 calcium/proton exchanger (cax); Region: cax; TIGR00378 527021001419 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 527021001420 YfkD-like protein; Region: YfkD; pfam14167 527021001421 Radical SAM superfamily; Region: Radical_SAM; pfam04055 527021001422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021001423 FeS/SAM binding site; other site 527021001424 YfkB-like domain; Region: YfkB; pfam08756 527021001425 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 527021001426 Fumarase C-terminus; Region: Fumerase_C; pfam05683 527021001427 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 527021001428 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 527021001429 NodB motif; other site 527021001430 active site 527021001431 catalytic site [active] 527021001432 Cd binding site [ion binding]; other site 527021001433 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 527021001434 endonuclease III; Region: ENDO3c; smart00478 527021001435 minor groove reading motif; other site 527021001436 helix-hairpin-helix signature motif; other site 527021001437 substrate binding pocket [chemical binding]; other site 527021001438 active site 527021001439 TRAM domain; Region: TRAM; pfam01938 527021001440 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 527021001441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021001442 S-adenosylmethionine binding site [chemical binding]; other site 527021001443 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 527021001444 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 527021001445 dimerization interface 3.5A [polypeptide binding]; other site 527021001446 active site 527021001447 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 527021001448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021001449 Walker A motif; other site 527021001450 ATP binding site [chemical binding]; other site 527021001451 Walker B motif; other site 527021001452 arginine finger; other site 527021001453 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 527021001454 hypothetical protein; Validated; Region: PRK06748 527021001455 S-methylmethionine transporter; Provisional; Region: PRK11387 527021001456 acetylornithine deacetylase; Validated; Region: PRK08596 527021001457 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 527021001458 metal binding site [ion binding]; metal-binding site 527021001459 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021001460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021001461 non-specific DNA binding site [nucleotide binding]; other site 527021001462 salt bridge; other site 527021001463 sequence-specific DNA binding site [nucleotide binding]; other site 527021001464 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 527021001465 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 527021001466 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 527021001467 glutaminase A; Region: Gln_ase; TIGR03814 527021001468 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 527021001469 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 527021001470 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 527021001471 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 527021001472 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 527021001473 active site turn [active] 527021001474 phosphorylation site [posttranslational modification] 527021001475 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021001476 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021001477 Sm and related proteins; Region: Sm_like; cl00259 527021001478 heptamer interface [polypeptide binding]; other site 527021001479 Sm1 motif; other site 527021001480 hexamer interface [polypeptide binding]; other site 527021001481 RNA binding site [nucleotide binding]; other site 527021001482 Sm2 motif; other site 527021001483 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 527021001484 active site 527021001485 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 527021001486 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 527021001487 active site 527021001488 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 527021001489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021001490 NAD(P) binding site [chemical binding]; other site 527021001491 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 527021001492 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 527021001493 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 527021001494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021001495 NAD(P) binding site [chemical binding]; other site 527021001496 active site 527021001497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 527021001498 active site 527021001499 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 527021001500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 527021001501 active site 527021001502 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 527021001503 Pyruvate formate lyase 1; Region: PFL1; cd01678 527021001504 coenzyme A binding site [chemical binding]; other site 527021001505 active site 527021001506 catalytic residues [active] 527021001507 glycine loop; other site 527021001508 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 527021001509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021001510 FeS/SAM binding site; other site 527021001511 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 527021001512 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 527021001513 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 527021001514 YfhE-like protein; Region: YfhE; pfam14152 527021001515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021001516 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 527021001517 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 527021001518 active site 527021001519 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 527021001520 TIGR01777 family protein; Region: yfcH 527021001521 putative NAD(P) binding site [chemical binding]; other site 527021001522 putative active site [active] 527021001523 recombination regulator RecX; Provisional; Region: recX; PRK14135 527021001524 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 527021001525 YpzG-like protein; Region: YpzG; pfam14139 527021001526 Small acid-soluble spore protein K family; Region: SspK; pfam08176 527021001527 WVELL protein; Region: WVELL; pfam14043 527021001528 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 527021001529 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 527021001530 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 527021001531 minor groove reading motif; other site 527021001532 helix-hairpin-helix signature motif; other site 527021001533 substrate binding pocket [chemical binding]; other site 527021001534 active site 527021001535 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 527021001536 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 527021001537 DNA binding and oxoG recognition site [nucleotide binding] 527021001538 YgaB-like protein; Region: YgaB; pfam14182 527021001539 hypothetical protein; Provisional; Region: PRK13662 527021001540 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 527021001541 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021001542 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 527021001543 Walker A/P-loop; other site 527021001544 ATP binding site [chemical binding]; other site 527021001545 Q-loop/lid; other site 527021001546 ABC transporter signature motif; other site 527021001547 Walker B; other site 527021001548 D-loop; other site 527021001549 H-loop/switch region; other site 527021001550 Predicted membrane protein [Function unknown]; Region: COG4129 527021001551 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 527021001552 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 527021001553 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 527021001554 active site 527021001555 dimer interface [polypeptide binding]; other site 527021001556 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 527021001557 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 527021001558 active site 527021001559 FMN binding site [chemical binding]; other site 527021001560 substrate binding site [chemical binding]; other site 527021001561 3Fe-4S cluster binding site [ion binding]; other site 527021001562 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 527021001563 domain_subunit interface; other site 527021001564 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 527021001565 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 527021001566 inhibitor-cofactor binding pocket; inhibition site 527021001567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021001568 catalytic residue [active] 527021001569 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 527021001570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021001571 Walker A/P-loop; other site 527021001572 ATP binding site [chemical binding]; other site 527021001573 Q-loop/lid; other site 527021001574 ABC transporter signature motif; other site 527021001575 Walker B; other site 527021001576 D-loop; other site 527021001577 H-loop/switch region; other site 527021001578 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 527021001579 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 527021001580 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 527021001581 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 527021001582 Ion channel; Region: Ion_trans_2; pfam07885 527021001583 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 527021001584 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 527021001585 catalytic triad [active] 527021001586 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 527021001587 metal binding site 2 [ion binding]; metal-binding site 527021001588 putative DNA binding helix; other site 527021001589 metal binding site 1 [ion binding]; metal-binding site 527021001590 dimer interface [polypeptide binding]; other site 527021001591 structural Zn2+ binding site [ion binding]; other site 527021001592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021001593 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021001594 Coenzyme A binding pocket [chemical binding]; other site 527021001595 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 527021001596 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 527021001597 hypothetical protein; Provisional; Region: PRK12378 527021001598 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 527021001599 nudix motif; other site 527021001600 Transglycosylase; Region: Transgly; pfam00912 527021001601 Thioredoxin; Region: Thioredoxin_4; pfam13462 527021001602 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 527021001603 epoxyqueuosine reductase; Region: TIGR00276 527021001604 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 527021001605 4Fe-4S binding domain; Region: Fer4; cl02805 527021001606 Putative amidase domain; Region: Amidase_6; pfam12671 527021001607 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 527021001608 PAS fold; Region: PAS_4; pfam08448 527021001609 PAS domain; Region: PAS_9; pfam13426 527021001610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021001611 putative active site [active] 527021001612 heme pocket [chemical binding]; other site 527021001613 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 527021001614 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 527021001615 metal binding site [ion binding]; metal-binding site 527021001616 active site 527021001617 I-site; other site 527021001618 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 527021001619 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 527021001620 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 527021001621 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 527021001622 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 527021001623 heme-binding site [chemical binding]; other site 527021001624 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021001625 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 527021001626 Leucine-rich repeats; other site 527021001627 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021001628 Substrate binding site [chemical binding]; other site 527021001629 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021001630 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021001631 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021001632 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021001633 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021001634 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021001635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021001636 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021001637 Coenzyme A binding pocket [chemical binding]; other site 527021001638 BCCT family transporter; Region: BCCT; pfam02028 527021001639 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 527021001640 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 527021001641 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 527021001642 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 527021001643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 527021001644 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 527021001645 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 527021001646 Cache domain; Region: Cache_1; pfam02743 527021001647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021001648 dimerization interface [polypeptide binding]; other site 527021001649 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021001650 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021001651 dimer interface [polypeptide binding]; other site 527021001652 putative CheW interface [polypeptide binding]; other site 527021001653 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 527021001654 PAS domain; Region: PAS; smart00091 527021001655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021001656 ATP binding site [chemical binding]; other site 527021001657 Mg2+ binding site [ion binding]; other site 527021001658 G-X-G motif; other site 527021001659 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 527021001660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021001661 active site 527021001662 phosphorylation site [posttranslational modification] 527021001663 intermolecular recognition site; other site 527021001664 dimerization interface [polypeptide binding]; other site 527021001665 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 527021001666 Citrate transporter; Region: CitMHS; pfam03600 527021001667 hypothetical protein; Provisional; Region: PRK12784 527021001668 NosL; Region: NosL; cl01769 527021001669 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 527021001670 Ankyrin repeat; Region: Ank; pfam00023 527021001671 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 527021001672 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 527021001673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021001674 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 527021001675 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 527021001676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021001677 Walker A/P-loop; other site 527021001678 ATP binding site [chemical binding]; other site 527021001679 Q-loop/lid; other site 527021001680 ABC transporter signature motif; other site 527021001681 Walker B; other site 527021001682 D-loop; other site 527021001683 H-loop/switch region; other site 527021001684 TOBE domain; Region: TOBE_2; pfam08402 527021001685 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 527021001686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021001687 dimer interface [polypeptide binding]; other site 527021001688 conserved gate region; other site 527021001689 putative PBP binding loops; other site 527021001690 ABC-ATPase subunit interface; other site 527021001691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 527021001692 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 527021001693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021001694 dimer interface [polypeptide binding]; other site 527021001695 conserved gate region; other site 527021001696 putative PBP binding loops; other site 527021001697 ABC-ATPase subunit interface; other site 527021001698 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 527021001699 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 527021001700 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021001701 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 527021001702 active site 527021001703 metal binding site [ion binding]; metal-binding site 527021001704 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021001705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021001706 active site 527021001707 phosphorylation site [posttranslational modification] 527021001708 intermolecular recognition site; other site 527021001709 dimerization interface [polypeptide binding]; other site 527021001710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021001711 DNA binding site [nucleotide binding] 527021001712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021001713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021001714 dimer interface [polypeptide binding]; other site 527021001715 phosphorylation site [posttranslational modification] 527021001716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021001717 ATP binding site [chemical binding]; other site 527021001718 Mg2+ binding site [ion binding]; other site 527021001719 G-X-G motif; other site 527021001720 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 527021001721 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 527021001722 putative active site [active] 527021001723 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 527021001724 Cache domain; Region: Cache_1; pfam02743 527021001725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021001726 dimerization interface [polypeptide binding]; other site 527021001727 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021001728 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021001729 dimer interface [polypeptide binding]; other site 527021001730 putative CheW interface [polypeptide binding]; other site 527021001731 sensory histidine kinase DcuS; Provisional; Region: PRK11086 527021001732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021001733 ATP binding site [chemical binding]; other site 527021001734 Mg2+ binding site [ion binding]; other site 527021001735 G-X-G motif; other site 527021001736 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 527021001737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021001738 active site 527021001739 phosphorylation site [posttranslational modification] 527021001740 intermolecular recognition site; other site 527021001741 dimerization interface [polypeptide binding]; other site 527021001742 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 527021001743 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 527021001744 Malic enzyme, N-terminal domain; Region: malic; pfam00390 527021001745 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 527021001746 putative NAD(P) binding site [chemical binding]; other site 527021001747 EamA-like transporter family; Region: EamA; pfam00892 527021001748 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 527021001749 EamA-like transporter family; Region: EamA; pfam00892 527021001750 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021001751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021001752 DNA-binding site [nucleotide binding]; DNA binding site 527021001753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021001754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021001755 homodimer interface [polypeptide binding]; other site 527021001756 catalytic residue [active] 527021001757 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 527021001758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021001759 Coenzyme A binding pocket [chemical binding]; other site 527021001760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021001761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021001762 dimerization interface [polypeptide binding]; other site 527021001763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021001764 dimer interface [polypeptide binding]; other site 527021001765 phosphorylation site [posttranslational modification] 527021001766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021001767 ATP binding site [chemical binding]; other site 527021001768 Mg2+ binding site [ion binding]; other site 527021001769 G-X-G motif; other site 527021001770 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021001771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021001772 active site 527021001773 phosphorylation site [posttranslational modification] 527021001774 intermolecular recognition site; other site 527021001775 dimerization interface [polypeptide binding]; other site 527021001776 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021001777 DNA binding site [nucleotide binding] 527021001778 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 527021001779 Arrestin_N terminal like; Region: LDB19; pfam13002 527021001780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021001781 Coenzyme A binding pocket [chemical binding]; other site 527021001782 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 527021001783 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 527021001784 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 527021001785 catalytic loop [active] 527021001786 iron binding site [ion binding]; other site 527021001787 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 527021001788 4Fe-4S binding domain; Region: Fer4; pfam00037 527021001789 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 527021001790 [4Fe-4S] binding site [ion binding]; other site 527021001791 molybdopterin cofactor binding site; other site 527021001792 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 527021001793 molybdopterin cofactor binding site; other site 527021001794 Uncharacterized conserved protein [Function unknown]; Region: COG2427 527021001795 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 527021001796 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 527021001797 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 527021001798 putative active site [active] 527021001799 catalytic site [active] 527021001800 putative metal binding site [ion binding]; other site 527021001801 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 527021001802 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 527021001803 hexamer interface [polypeptide binding]; other site 527021001804 ligand binding site [chemical binding]; other site 527021001805 putative active site [active] 527021001806 NAD(P) binding site [chemical binding]; other site 527021001807 amino acid transporter; Region: 2A0306; TIGR00909 527021001808 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 527021001809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021001810 dimerization interface [polypeptide binding]; other site 527021001811 putative DNA binding site [nucleotide binding]; other site 527021001812 putative Zn2+ binding site [ion binding]; other site 527021001813 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 527021001814 metal-binding site [ion binding] 527021001815 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 527021001816 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 527021001817 metal-binding site [ion binding] 527021001818 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 527021001819 Soluble P-type ATPase [General function prediction only]; Region: COG4087 527021001820 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 527021001821 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 527021001822 active site 527021001823 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021001824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021001825 non-specific DNA binding site [nucleotide binding]; other site 527021001826 salt bridge; other site 527021001827 sequence-specific DNA binding site [nucleotide binding]; other site 527021001828 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021001829 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 527021001830 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 527021001831 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 527021001832 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 527021001833 active site 527021001834 Zn binding site [ion binding]; other site 527021001835 Uncharacterized conserved protein [Function unknown]; Region: COG0398 527021001836 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 527021001837 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 527021001838 VanW like protein; Region: VanW; pfam04294 527021001839 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 527021001840 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 527021001841 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 527021001842 Nucleoside recognition; Region: Gate; pfam07670 527021001843 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 527021001844 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021001845 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 527021001846 putative metal binding site [ion binding]; other site 527021001847 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 527021001848 Domain of unknown function DUF21; Region: DUF21; pfam01595 527021001849 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 527021001850 Transporter associated domain; Region: CorC_HlyC; smart01091 527021001851 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 527021001852 Aspartase; Region: Aspartase; cd01357 527021001853 active sites [active] 527021001854 tetramer interface [polypeptide binding]; other site 527021001855 L-lactate permease; Region: Lactate_perm; cl00701 527021001856 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 527021001857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021001858 dimerization interface [polypeptide binding]; other site 527021001859 putative Zn2+ binding site [ion binding]; other site 527021001860 putative DNA binding site [nucleotide binding]; other site 527021001861 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 527021001862 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 527021001863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021001864 putative substrate translocation pore; other site 527021001865 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 527021001866 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 527021001867 siderophore binding site; other site 527021001868 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 527021001869 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021001870 ABC-ATPase subunit interface; other site 527021001871 dimer interface [polypeptide binding]; other site 527021001872 putative PBP binding regions; other site 527021001873 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 527021001874 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021001875 ABC-ATPase subunit interface; other site 527021001876 dimer interface [polypeptide binding]; other site 527021001877 putative PBP binding regions; other site 527021001878 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 527021001879 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 527021001880 Walker A/P-loop; other site 527021001881 ATP binding site [chemical binding]; other site 527021001882 Q-loop/lid; other site 527021001883 ABC transporter signature motif; other site 527021001884 Walker B; other site 527021001885 D-loop; other site 527021001886 H-loop/switch region; other site 527021001887 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021001888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021001889 S-adenosylmethionine binding site [chemical binding]; other site 527021001890 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 527021001891 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021001892 catalytic residue [active] 527021001893 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 527021001894 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 527021001895 putative active site [active] 527021001896 putative NTP binding site [chemical binding]; other site 527021001897 putative nucleic acid binding site [nucleotide binding]; other site 527021001898 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 527021001899 active site 527021001900 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 527021001901 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 527021001902 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 527021001903 NAD binding site [chemical binding]; other site 527021001904 homodimer interface [polypeptide binding]; other site 527021001905 active site 527021001906 putative substrate binding site [chemical binding]; other site 527021001907 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 527021001908 nudix motif; other site 527021001909 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 527021001910 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 527021001911 metal ion-dependent adhesion site (MIDAS); other site 527021001912 MoxR-like ATPases [General function prediction only]; Region: COG0714 527021001913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021001914 Walker A motif; other site 527021001915 ATP binding site [chemical binding]; other site 527021001916 Walker B motif; other site 527021001917 arginine finger; other site 527021001918 cardiolipin synthetase; Reviewed; Region: PRK12452 527021001919 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 527021001920 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 527021001921 putative active site [active] 527021001922 catalytic site [active] 527021001923 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 527021001924 putative active site [active] 527021001925 catalytic site [active] 527021001926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021001927 PAS domain; Region: PAS_9; pfam13426 527021001928 putative active site [active] 527021001929 heme pocket [chemical binding]; other site 527021001930 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 527021001931 metal binding site [ion binding]; metal-binding site 527021001932 active site 527021001933 I-site; other site 527021001934 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 527021001935 Amino acid permease; Region: AA_permease_2; pfam13520 527021001936 Spore germination protein; Region: Spore_permease; cl17796 527021001937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021001938 DNA-binding site [nucleotide binding]; DNA binding site 527021001939 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 527021001940 UTRA domain; Region: UTRA; pfam07702 527021001941 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 527021001942 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 527021001943 active site turn [active] 527021001944 phosphorylation site [posttranslational modification] 527021001945 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 527021001946 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 527021001947 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 527021001948 Ca binding site [ion binding]; other site 527021001949 active site 527021001950 catalytic site [active] 527021001951 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 527021001952 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 527021001953 Spore germination protein; Region: Spore_permease; cl17796 527021001954 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021001955 CAAX protease self-immunity; Region: Abi; pfam02517 527021001956 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 527021001957 active site 527021001958 ATP binding site [chemical binding]; other site 527021001959 substrate binding site [chemical binding]; other site 527021001960 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 527021001961 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 527021001962 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 527021001963 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 527021001964 Walker A/P-loop; other site 527021001965 ATP binding site [chemical binding]; other site 527021001966 Q-loop/lid; other site 527021001967 ABC transporter signature motif; other site 527021001968 Walker B; other site 527021001969 D-loop; other site 527021001970 H-loop/switch region; other site 527021001971 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 527021001972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 527021001973 substrate binding pocket [chemical binding]; other site 527021001974 membrane-bound complex binding site; other site 527021001975 hinge residues; other site 527021001976 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 527021001977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021001978 dimer interface [polypeptide binding]; other site 527021001979 conserved gate region; other site 527021001980 putative PBP binding loops; other site 527021001981 ABC-ATPase subunit interface; other site 527021001982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021001983 dimer interface [polypeptide binding]; other site 527021001984 conserved gate region; other site 527021001985 putative PBP binding loops; other site 527021001986 ABC-ATPase subunit interface; other site 527021001987 S-methylmethionine transporter; Provisional; Region: PRK11387 527021001988 OsmC-like protein; Region: OsmC; pfam02566 527021001989 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 527021001990 nucleotide binding site/active site [active] 527021001991 HIT family signature motif; other site 527021001992 catalytic residue [active] 527021001993 RNA polymerase sigma factor; Provisional; Region: PRK12542 527021001994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021001995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021001996 DNA binding residues [nucleotide binding] 527021001997 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 527021001998 Predicted transcriptional regulator [Transcription]; Region: COG2378 527021001999 HTH domain; Region: HTH_11; pfam08279 527021002000 WYL domain; Region: WYL; pfam13280 527021002001 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 527021002002 RibD C-terminal domain; Region: RibD_C; cl17279 527021002003 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 527021002004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021002005 dimerization interface [polypeptide binding]; other site 527021002006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021002007 dimer interface [polypeptide binding]; other site 527021002008 phosphorylation site [posttranslational modification] 527021002009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021002010 ATP binding site [chemical binding]; other site 527021002011 Mg2+ binding site [ion binding]; other site 527021002012 G-X-G motif; other site 527021002013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021002014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021002015 active site 527021002016 phosphorylation site [posttranslational modification] 527021002017 intermolecular recognition site; other site 527021002018 dimerization interface [polypeptide binding]; other site 527021002019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021002020 DNA binding site [nucleotide binding] 527021002021 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 527021002022 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 527021002023 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 527021002024 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 527021002025 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 527021002026 Sulfate transporter family; Region: Sulfate_transp; pfam00916 527021002027 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 527021002028 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 527021002029 Ligand Binding Site [chemical binding]; other site 527021002030 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 527021002031 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 527021002032 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 527021002033 peptide binding site [polypeptide binding]; other site 527021002034 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 527021002035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021002036 dimer interface [polypeptide binding]; other site 527021002037 conserved gate region; other site 527021002038 putative PBP binding loops; other site 527021002039 ABC-ATPase subunit interface; other site 527021002040 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 527021002041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021002042 putative PBP binding loops; other site 527021002043 ABC-ATPase subunit interface; other site 527021002044 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 527021002045 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021002046 Walker A/P-loop; other site 527021002047 ATP binding site [chemical binding]; other site 527021002048 Q-loop/lid; other site 527021002049 ABC transporter signature motif; other site 527021002050 Walker B; other site 527021002051 D-loop; other site 527021002052 H-loop/switch region; other site 527021002053 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 527021002054 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 527021002055 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021002056 Walker A/P-loop; other site 527021002057 ATP binding site [chemical binding]; other site 527021002058 Q-loop/lid; other site 527021002059 ABC transporter signature motif; other site 527021002060 Walker B; other site 527021002061 D-loop; other site 527021002062 H-loop/switch region; other site 527021002063 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 527021002064 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 527021002065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002066 putative substrate translocation pore; other site 527021002067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021002068 MarR family; Region: MarR; pfam01047 527021002069 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 527021002070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002071 putative substrate translocation pore; other site 527021002072 Transcriptional regulators [Transcription]; Region: PurR; COG1609 527021002073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 527021002074 DNA binding site [nucleotide binding] 527021002075 domain linker motif; other site 527021002076 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 527021002077 dimerization interface [polypeptide binding]; other site 527021002078 ligand binding site [chemical binding]; other site 527021002079 sodium binding site [ion binding]; other site 527021002080 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 527021002081 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 527021002082 substrate binding site [chemical binding]; other site 527021002083 dimer interface [polypeptide binding]; other site 527021002084 ATP binding site [chemical binding]; other site 527021002085 D-ribose pyranase; Provisional; Region: PRK11797 527021002086 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 527021002087 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 527021002088 Walker A/P-loop; other site 527021002089 ATP binding site [chemical binding]; other site 527021002090 Q-loop/lid; other site 527021002091 ABC transporter signature motif; other site 527021002092 Walker B; other site 527021002093 D-loop; other site 527021002094 H-loop/switch region; other site 527021002095 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 527021002096 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 527021002097 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 527021002098 TM-ABC transporter signature motif; other site 527021002099 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 527021002100 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 527021002101 ligand binding site [chemical binding]; other site 527021002102 dimerization interface [polypeptide binding]; other site 527021002103 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 527021002104 active site 527021002105 intersubunit interactions; other site 527021002106 catalytic residue [active] 527021002107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 527021002108 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 527021002109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021002111 putative substrate translocation pore; other site 527021002112 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 527021002113 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 527021002114 putative NAD(P) binding site [chemical binding]; other site 527021002115 catalytic Zn binding site [ion binding]; other site 527021002116 Ion channel; Region: Ion_trans_2; pfam07885 527021002117 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 527021002118 Zn binding site [ion binding]; other site 527021002119 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 527021002120 putative catalytic site [active] 527021002121 metal binding site A [ion binding]; metal-binding site 527021002122 phosphate binding site [ion binding]; other site 527021002123 metal binding site C [ion binding]; metal-binding site 527021002124 metal binding site B [ion binding]; metal-binding site 527021002125 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 527021002126 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 527021002127 Int/Topo IB signature motif; other site 527021002128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021002129 non-specific DNA binding site [nucleotide binding]; other site 527021002130 salt bridge; other site 527021002131 sequence-specific DNA binding site [nucleotide binding]; other site 527021002132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021002133 sequence-specific DNA binding site [nucleotide binding]; other site 527021002134 salt bridge; other site 527021002135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021002136 non-specific DNA binding site [nucleotide binding]; other site 527021002137 salt bridge; other site 527021002138 sequence-specific DNA binding site [nucleotide binding]; other site 527021002139 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 527021002140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 527021002141 DNA binding residues [nucleotide binding] 527021002142 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 527021002143 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 527021002144 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 527021002145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021002146 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 527021002147 Walker A motif; other site 527021002148 ATP binding site [chemical binding]; other site 527021002149 Walker B motif; other site 527021002150 Uncharacterized conserved protein [Function unknown]; Region: COG5582 527021002151 UPF0302 domain; Region: UPF0302; pfam08864 527021002152 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 527021002153 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 527021002154 Homeodomain-like domain; Region: HTH_23; cl17451 527021002155 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 527021002156 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021002157 Prophage antirepressor [Transcription]; Region: COG3617 527021002158 BRO family, N-terminal domain; Region: Bro-N; smart01040 527021002159 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 527021002160 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 527021002161 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 527021002162 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 527021002163 catalytic residues [active] 527021002164 catalytic nucleophile [active] 527021002165 Presynaptic Site I dimer interface [polypeptide binding]; other site 527021002166 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 527021002167 Synaptic Flat tetramer interface [polypeptide binding]; other site 527021002168 Synaptic Site I dimer interface [polypeptide binding]; other site 527021002169 DNA binding site [nucleotide binding] 527021002170 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 527021002171 DNA-binding interface [nucleotide binding]; DNA binding site 527021002172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 527021002173 Terminase-like family; Region: Terminase_6; pfam03237 527021002174 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 527021002175 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 527021002176 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 527021002177 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 527021002178 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876 527021002179 H-type lectin domain; Region: H_lectin; pfam09458 527021002180 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 527021002181 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 527021002182 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 527021002183 amidase catalytic site [active] 527021002184 Zn binding residues [ion binding]; other site 527021002185 substrate binding site [chemical binding]; other site 527021002186 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021002187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 527021002188 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 527021002189 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 527021002190 Replication-relaxation; Region: Replic_Relax; pfam13814 527021002191 Helix-turn-helix domain; Region: HTH_36; pfam13730 527021002192 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 527021002193 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 527021002194 dimer interface [polypeptide binding]; other site 527021002195 active site 527021002196 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 527021002197 substrate binding site [chemical binding]; other site 527021002198 catalytic residue [active] 527021002199 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 527021002200 FAD binding domain; Region: FAD_binding_4; pfam01565 527021002201 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 527021002202 VanZ like family; Region: VanZ; pfam04892 527021002203 RDD family; Region: RDD; pfam06271 527021002204 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 527021002205 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 527021002206 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 527021002207 homodimer interface [polypeptide binding]; other site 527021002208 putative GKAP docking site [polypeptide binding]; other site 527021002209 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021002210 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021002211 dimer interface [polypeptide binding]; other site 527021002212 putative CheW interface [polypeptide binding]; other site 527021002213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 527021002214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 527021002215 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021002216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021002217 non-specific DNA binding site [nucleotide binding]; other site 527021002218 salt bridge; other site 527021002219 sequence-specific DNA binding site [nucleotide binding]; other site 527021002220 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 527021002221 active site 527021002222 catalytic site [active] 527021002223 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 527021002224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002225 putative substrate translocation pore; other site 527021002226 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 527021002227 Archaeal flagella protein; Region: Arch_fla_DE; cl01322 527021002228 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 527021002229 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 527021002230 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 527021002231 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 527021002232 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021002233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021002234 non-specific DNA binding site [nucleotide binding]; other site 527021002235 salt bridge; other site 527021002236 sequence-specific DNA binding site [nucleotide binding]; other site 527021002237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021002238 Coenzyme A binding pocket [chemical binding]; other site 527021002239 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 527021002240 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 527021002241 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 527021002242 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 527021002243 TrkA-N domain; Region: TrkA_N; pfam02254 527021002244 TrkA-C domain; Region: TrkA_C; pfam02080 527021002245 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 527021002246 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 527021002247 Subunit I/III interface [polypeptide binding]; other site 527021002248 Subunit III/IV interface [polypeptide binding]; other site 527021002249 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 527021002250 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 527021002251 D-pathway; other site 527021002252 Putative ubiquinol binding site [chemical binding]; other site 527021002253 Low-spin heme (heme b) binding site [chemical binding]; other site 527021002254 Putative water exit pathway; other site 527021002255 Binuclear center (heme o3/CuB) [ion binding]; other site 527021002256 K-pathway; other site 527021002257 Putative proton exit pathway; other site 527021002258 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 527021002259 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 527021002260 S-methylmethionine transporter; Provisional; Region: PRK11387 527021002261 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 527021002262 putative active site [active] 527021002263 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 527021002264 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 527021002265 metal binding site [ion binding]; metal-binding site 527021002266 dimer interface [polypeptide binding]; other site 527021002267 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 527021002268 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 527021002269 Na binding site [ion binding]; other site 527021002270 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021002271 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 527021002272 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 527021002273 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 527021002274 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 527021002275 Nucleoside recognition; Region: Gate; pfam07670 527021002276 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 527021002277 Nucleoside recognition; Region: Gate; pfam07670 527021002278 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 527021002279 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 527021002280 G1 box; other site 527021002281 GTP/Mg2+ binding site [chemical binding]; other site 527021002282 Switch I region; other site 527021002283 G2 box; other site 527021002284 G3 box; other site 527021002285 Switch II region; other site 527021002286 G4 box; other site 527021002287 G5 box; other site 527021002288 FeoA domain; Region: FeoA; pfam04023 527021002289 phosphate binding protein; Region: ptsS_2; TIGR02136 527021002290 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 527021002291 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 527021002292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021002293 dimer interface [polypeptide binding]; other site 527021002294 conserved gate region; other site 527021002295 putative PBP binding loops; other site 527021002296 ABC-ATPase subunit interface; other site 527021002297 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 527021002298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021002299 dimer interface [polypeptide binding]; other site 527021002300 conserved gate region; other site 527021002301 putative PBP binding loops; other site 527021002302 ABC-ATPase subunit interface; other site 527021002303 AAA domain; Region: AAA_33; pfam13671 527021002304 AAA domain; Region: AAA_17; pfam13207 527021002305 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 527021002306 Protein export membrane protein; Region: SecD_SecF; cl14618 527021002307 FOG: CBS domain [General function prediction only]; Region: COG0517 527021002308 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 527021002309 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 527021002310 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 527021002311 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021002312 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021002313 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021002314 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 527021002315 Peptidase family M23; Region: Peptidase_M23; pfam01551 527021002316 Putative transcription activator [Transcription]; Region: TenA; COG0819 527021002317 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 527021002318 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 527021002319 Walker A/P-loop; other site 527021002320 ATP binding site [chemical binding]; other site 527021002321 Q-loop/lid; other site 527021002322 ABC transporter signature motif; other site 527021002323 Walker B; other site 527021002324 D-loop; other site 527021002325 H-loop/switch region; other site 527021002326 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 527021002327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021002328 dimer interface [polypeptide binding]; other site 527021002329 conserved gate region; other site 527021002330 putative PBP binding loops; other site 527021002331 ABC-ATPase subunit interface; other site 527021002332 NMT1/THI5 like; Region: NMT1; pfam09084 527021002333 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 527021002334 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 527021002335 thiamine phosphate binding site [chemical binding]; other site 527021002336 active site 527021002337 pyrophosphate binding site [ion binding]; other site 527021002338 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 527021002339 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 527021002340 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 527021002341 thiS-thiF/thiG interaction site; other site 527021002342 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 527021002343 ThiS interaction site; other site 527021002344 putative active site [active] 527021002345 tetramer interface [polypeptide binding]; other site 527021002346 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 527021002347 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 527021002348 ATP binding site [chemical binding]; other site 527021002349 substrate interface [chemical binding]; other site 527021002350 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 527021002351 dimer interface [polypeptide binding]; other site 527021002352 substrate binding site [chemical binding]; other site 527021002353 ATP binding site [chemical binding]; other site 527021002354 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 527021002355 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 527021002356 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 527021002357 Soluble P-type ATPase [General function prediction only]; Region: COG4087 527021002358 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 527021002359 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 527021002360 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 527021002361 Ligand Binding Site [chemical binding]; other site 527021002362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021002364 putative substrate translocation pore; other site 527021002365 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021002366 MarR family; Region: MarR; pfam01047 527021002367 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 527021002368 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 527021002369 active site 527021002370 nucleophile elbow; other site 527021002371 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 527021002372 short chain dehydrogenase; Provisional; Region: PRK06701 527021002373 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 527021002374 NAD binding site [chemical binding]; other site 527021002375 metal binding site [ion binding]; metal-binding site 527021002376 active site 527021002377 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 527021002378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 527021002379 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 527021002380 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 527021002381 putative substrate binding site [chemical binding]; other site 527021002382 putative ATP binding site [chemical binding]; other site 527021002383 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 527021002384 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 527021002385 substrate binding [chemical binding]; other site 527021002386 active site 527021002387 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 527021002388 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 527021002389 active site turn [active] 527021002390 phosphorylation site [posttranslational modification] 527021002391 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 527021002392 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 527021002393 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 527021002394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 527021002395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 527021002396 DNA binding site [nucleotide binding] 527021002397 domain linker motif; other site 527021002398 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 527021002399 dimerization interface [polypeptide binding]; other site 527021002400 ligand binding site [chemical binding]; other site 527021002401 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 527021002402 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 527021002403 catalytic residues [active] 527021002404 putative disulfide oxidoreductase; Provisional; Region: PRK03113 527021002405 YhdB-like protein; Region: YhdB; pfam14148 527021002406 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 527021002407 Spore germination protein; Region: Spore_permease; pfam03845 527021002408 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 527021002409 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 527021002410 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021002411 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 527021002412 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 527021002413 putative FMN binding site [chemical binding]; other site 527021002414 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 527021002415 SpoVR like protein; Region: SpoVR; pfam04293 527021002416 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 527021002417 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021002418 MarR family; Region: MarR_2; pfam12802 527021002419 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 527021002420 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 527021002421 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 527021002422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 527021002423 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021002424 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 527021002425 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 527021002426 active site residue [active] 527021002427 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 527021002428 putative homodimer interface [polypeptide binding]; other site 527021002429 putative homotetramer interface [polypeptide binding]; other site 527021002430 putative metal binding site [ion binding]; other site 527021002431 putative homodimer-homodimer interface [polypeptide binding]; other site 527021002432 putative allosteric switch controlling residues; other site 527021002433 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 527021002434 CPxP motif; other site 527021002435 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 527021002436 active site residue [active] 527021002437 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 527021002438 active site residue [active] 527021002439 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 527021002440 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 527021002441 CPxP motif; other site 527021002442 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 527021002443 active site residue [active] 527021002444 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 527021002445 active site residue [active] 527021002446 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 527021002447 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 527021002448 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 527021002449 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 527021002450 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 527021002451 NADP binding site [chemical binding]; other site 527021002452 dimer interface [polypeptide binding]; other site 527021002453 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 527021002454 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 527021002455 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 527021002456 PhoU domain; Region: PhoU; pfam01895 527021002457 PhoU domain; Region: PhoU; pfam01895 527021002458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021002460 putative substrate translocation pore; other site 527021002461 Uncharacterized conserved protein [Function unknown]; Region: COG3589 527021002462 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 527021002463 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 527021002464 HTH domain; Region: HTH_11; pfam08279 527021002465 Mga helix-turn-helix domain; Region: Mga; pfam05043 527021002466 PRD domain; Region: PRD; pfam00874 527021002467 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 527021002468 active site 527021002469 P-loop; other site 527021002470 phosphorylation site [posttranslational modification] 527021002471 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 527021002472 active site 527021002473 phosphorylation site [posttranslational modification] 527021002474 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 527021002475 active site 527021002476 methionine cluster; other site 527021002477 phosphorylation site [posttranslational modification] 527021002478 metal binding site [ion binding]; metal-binding site 527021002479 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 527021002480 active site 527021002481 P-loop; other site 527021002482 phosphorylation site [posttranslational modification] 527021002483 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 527021002484 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 527021002485 Uncharacterized conserved protein [Function unknown]; Region: COG3589 527021002486 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 527021002487 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021002488 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021002489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 527021002490 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 527021002491 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 527021002492 FtsX-like permease family; Region: FtsX; pfam02687 527021002493 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021002494 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021002495 Walker A/P-loop; other site 527021002496 ATP binding site [chemical binding]; other site 527021002497 Q-loop/lid; other site 527021002498 ABC transporter signature motif; other site 527021002499 Walker B; other site 527021002500 D-loop; other site 527021002501 H-loop/switch region; other site 527021002502 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 527021002503 HlyD family secretion protein; Region: HlyD_3; pfam13437 527021002504 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 527021002505 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 527021002506 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 527021002507 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 527021002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021002509 dimer interface [polypeptide binding]; other site 527021002510 conserved gate region; other site 527021002511 ABC-ATPase subunit interface; other site 527021002512 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 527021002513 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 527021002514 dimanganese center [ion binding]; other site 527021002515 CotJB protein; Region: CotJB; pfam12652 527021002516 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 527021002517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021002518 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 527021002519 active site 527021002520 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 527021002521 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 527021002522 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 527021002523 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 527021002524 putative DNA binding site [nucleotide binding]; other site 527021002525 putative homodimer interface [polypeptide binding]; other site 527021002526 Uncharacterized conserved protein [Function unknown]; Region: COG3339 527021002527 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 527021002528 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 527021002529 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 527021002530 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 527021002531 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 527021002532 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021002533 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 527021002534 active site 527021002535 metal binding site [ion binding]; metal-binding site 527021002536 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 527021002537 Interdomain contacts; other site 527021002538 Cytokine receptor motif; other site 527021002539 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 527021002540 amino acid transporter; Region: 2A0306; TIGR00909 527021002541 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 527021002542 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 527021002543 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 527021002544 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 527021002545 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 527021002546 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 527021002547 putative active site [active] 527021002548 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 527021002549 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 527021002550 putative active site [active] 527021002551 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 527021002552 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 527021002553 active site turn [active] 527021002554 phosphorylation site [posttranslational modification] 527021002555 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 527021002556 Uncharacterized conserved protein [Function unknown]; Region: COG3589 527021002557 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 527021002558 DoxX; Region: DoxX; pfam07681 527021002559 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 527021002560 hypothetical protein; Provisional; Region: PRK06770 527021002561 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021002562 EamA-like transporter family; Region: EamA; pfam00892 527021002563 EamA-like transporter family; Region: EamA; pfam00892 527021002564 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 527021002565 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 527021002566 AsnC family; Region: AsnC_trans_reg; pfam01037 527021002567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021002568 Coenzyme A binding pocket [chemical binding]; other site 527021002569 short chain dehydrogenase; Provisional; Region: PRK06138 527021002570 classical (c) SDRs; Region: SDR_c; cd05233 527021002571 NAD(P) binding site [chemical binding]; other site 527021002572 active site 527021002573 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 527021002574 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 527021002575 DNA binding residues [nucleotide binding] 527021002576 putative dimer interface [polypeptide binding]; other site 527021002577 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 527021002578 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 527021002579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021002580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021002581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021002582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002584 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021002585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021002586 dimerization interface [polypeptide binding]; other site 527021002587 putative DNA binding site [nucleotide binding]; other site 527021002588 putative Zn2+ binding site [ion binding]; other site 527021002589 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 527021002590 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 527021002591 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 527021002592 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 527021002593 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 527021002594 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 527021002595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021002596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002597 putative substrate translocation pore; other site 527021002598 intracellular protease, PfpI family; Region: PfpI; TIGR01382 527021002599 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 527021002600 proposed catalytic triad [active] 527021002601 conserved cys residue [active] 527021002602 hydroperoxidase II; Provisional; Region: katE; PRK11249 527021002603 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 527021002604 tetramer interface [polypeptide binding]; other site 527021002605 heme binding pocket [chemical binding]; other site 527021002606 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 527021002607 domain interactions; other site 527021002608 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 527021002609 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 527021002610 Spore germination protein; Region: Spore_permease; cl17796 527021002611 glutamate racemase; Provisional; Region: PRK00865 527021002612 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 527021002613 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 527021002614 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 527021002615 tetrameric interface [polypeptide binding]; other site 527021002616 activator binding site; other site 527021002617 NADP binding site [chemical binding]; other site 527021002618 substrate binding site [chemical binding]; other site 527021002619 catalytic residues [active] 527021002620 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021002621 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 527021002622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021002623 Walker A/P-loop; other site 527021002624 ATP binding site [chemical binding]; other site 527021002625 Q-loop/lid; other site 527021002626 ABC transporter signature motif; other site 527021002627 Walker B; other site 527021002628 D-loop; other site 527021002629 H-loop/switch region; other site 527021002630 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021002631 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 527021002632 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 527021002633 Walker A/P-loop; other site 527021002634 ATP binding site [chemical binding]; other site 527021002635 Q-loop/lid; other site 527021002636 ABC transporter signature motif; other site 527021002637 Walker B; other site 527021002638 D-loop; other site 527021002639 H-loop/switch region; other site 527021002640 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 527021002641 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 527021002642 substrate binding pocket [chemical binding]; other site 527021002643 membrane-bound complex binding site; other site 527021002644 hinge residues; other site 527021002645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021002646 dimer interface [polypeptide binding]; other site 527021002647 conserved gate region; other site 527021002648 putative PBP binding loops; other site 527021002649 ABC-ATPase subunit interface; other site 527021002650 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 527021002651 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 527021002652 Walker A/P-loop; other site 527021002653 ATP binding site [chemical binding]; other site 527021002654 Q-loop/lid; other site 527021002655 ABC transporter signature motif; other site 527021002656 Walker B; other site 527021002657 D-loop; other site 527021002658 H-loop/switch region; other site 527021002659 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 527021002660 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 527021002661 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 527021002662 Protein of unknown function (DUF445); Region: DUF445; pfam04286 527021002663 hypothetical protein; Provisional; Region: PRK13676 527021002664 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 527021002665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 527021002666 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 527021002667 Probable transposase; Region: OrfB_IS605; pfam01385 527021002668 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 527021002669 acetolactate synthase; Reviewed; Region: PRK08617 527021002670 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 527021002671 PYR/PP interface [polypeptide binding]; other site 527021002672 dimer interface [polypeptide binding]; other site 527021002673 TPP binding site [chemical binding]; other site 527021002674 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 527021002675 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 527021002676 TPP-binding site [chemical binding]; other site 527021002677 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 527021002678 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 527021002679 active site 527021002680 DNA binding site [nucleotide binding] 527021002681 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 527021002682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 527021002683 active site 527021002684 motif I; other site 527021002685 motif II; other site 527021002686 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 527021002687 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 527021002688 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 527021002689 Cna protein B-type domain; Region: Cna_B; pfam05738 527021002690 Cna protein B-type domain; Region: Cna_B; pfam05738 527021002691 Cna protein B-type domain; Region: Cna_B; pfam05738 527021002692 Cna protein B-type domain; Region: Cna_B; pfam05738 527021002693 Cna protein B-type domain; Region: Cna_B; pfam05738 527021002694 Cna protein B-type domain; Region: Cna_B; pfam05738 527021002695 Cna protein B-type domain; Region: Cna_B; pfam05738 527021002696 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 527021002697 amidase catalytic site [active] 527021002698 Zn binding residues [ion binding]; other site 527021002699 substrate binding site [chemical binding]; other site 527021002700 S-layer homology domain; Region: SLH; pfam00395 527021002701 S-layer homology domain; Region: SLH; pfam00395 527021002702 S-layer homology domain; Region: SLH; pfam00395 527021002703 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 527021002704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021002705 FeS/SAM binding site; other site 527021002706 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 527021002707 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 527021002708 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 527021002709 acyl-activating enzyme (AAE) consensus motif; other site 527021002710 acyl-activating enzyme (AAE) consensus motif; other site 527021002711 putative AMP binding site [chemical binding]; other site 527021002712 putative active site [active] 527021002713 putative CoA binding site [chemical binding]; other site 527021002714 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 527021002715 Sulfate transporter family; Region: Sulfate_transp; pfam00916 527021002716 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 527021002717 stage V sporulation protein B; Region: spore_V_B; TIGR02900 527021002718 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 527021002719 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 527021002720 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 527021002721 S-layer homology domain; Region: SLH; pfam00395 527021002722 S-layer homology domain; Region: SLH; pfam00395 527021002723 S-layer homology domain; Region: SLH; pfam00395 527021002724 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 527021002725 O-Antigen ligase; Region: Wzy_C; cl04850 527021002726 enoyl-CoA hydratase; Provisional; Region: PRK07659 527021002727 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 527021002728 substrate binding site [chemical binding]; other site 527021002729 oxyanion hole (OAH) forming residues; other site 527021002730 trimer interface [polypeptide binding]; other site 527021002731 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 527021002732 metal binding site [ion binding]; metal-binding site 527021002733 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 527021002734 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 527021002735 putative oligomer interface [polypeptide binding]; other site 527021002736 putative active site [active] 527021002737 metal binding site [ion binding]; metal-binding site 527021002738 S-layer homology domain; Region: SLH; pfam00395 527021002739 S-layer homology domain; Region: SLH; pfam00395 527021002740 S-layer homology domain; Region: SLH; pfam00395 527021002741 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 527021002742 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 527021002743 active site 527021002744 metal binding site [ion binding]; metal-binding site 527021002745 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 527021002746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021002747 S-adenosylmethionine binding site [chemical binding]; other site 527021002748 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 527021002749 proline racemase; Provisional; Region: PRK13969 527021002750 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 527021002751 ornithine cyclodeaminase; Validated; Region: PRK08618 527021002752 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 527021002753 NAD(P) binding site [chemical binding]; other site 527021002754 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 527021002755 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 527021002756 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 527021002757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021002758 dimer interface [polypeptide binding]; other site 527021002759 conserved gate region; other site 527021002760 putative PBP binding loops; other site 527021002761 ABC-ATPase subunit interface; other site 527021002762 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 527021002763 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 527021002764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021002765 dimer interface [polypeptide binding]; other site 527021002766 conserved gate region; other site 527021002767 putative PBP binding loops; other site 527021002768 ABC-ATPase subunit interface; other site 527021002769 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 527021002770 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021002771 Walker A/P-loop; other site 527021002772 ATP binding site [chemical binding]; other site 527021002773 Q-loop/lid; other site 527021002774 ABC transporter signature motif; other site 527021002775 Walker B; other site 527021002776 D-loop; other site 527021002777 H-loop/switch region; other site 527021002778 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 527021002779 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 527021002780 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021002781 Walker A/P-loop; other site 527021002782 ATP binding site [chemical binding]; other site 527021002783 Q-loop/lid; other site 527021002784 ABC transporter signature motif; other site 527021002785 Walker B; other site 527021002786 D-loop; other site 527021002787 H-loop/switch region; other site 527021002788 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 527021002789 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 527021002790 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 527021002791 catalytic residues [active] 527021002792 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 527021002793 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 527021002794 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 527021002795 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 527021002796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002797 putative substrate translocation pore; other site 527021002798 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 527021002799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021002800 putative active site [active] 527021002801 heme pocket [chemical binding]; other site 527021002802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021002803 ATP binding site [chemical binding]; other site 527021002804 Mg2+ binding site [ion binding]; other site 527021002805 G-X-G motif; other site 527021002806 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 527021002807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021002808 active site 527021002809 phosphorylation site [posttranslational modification] 527021002810 intermolecular recognition site; other site 527021002811 dimerization interface [polypeptide binding]; other site 527021002812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 527021002813 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 527021002814 active site 527021002815 8-oxo-dGMP binding site [chemical binding]; other site 527021002816 nudix motif; other site 527021002817 metal binding site [ion binding]; metal-binding site 527021002818 PLD-like domain; Region: PLDc_2; pfam13091 527021002819 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 527021002820 putative homodimer interface [polypeptide binding]; other site 527021002821 putative active site [active] 527021002822 catalytic site [active] 527021002823 DEAD-like helicases superfamily; Region: DEXDc; smart00487 527021002824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021002825 ATP binding site [chemical binding]; other site 527021002826 putative Mg++ binding site [ion binding]; other site 527021002827 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 527021002828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021002829 nucleotide binding region [chemical binding]; other site 527021002830 ATP-binding site [chemical binding]; other site 527021002831 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 527021002832 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 527021002833 replicative DNA helicase; Provisional; Region: PRK06749 527021002834 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 527021002835 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 527021002836 Walker A motif; other site 527021002837 ATP binding site [chemical binding]; other site 527021002838 Walker B motif; other site 527021002839 DNA binding loops [nucleotide binding] 527021002840 Uncharacterized conserved protein [Function unknown]; Region: COG5464 527021002841 Predicted transcriptional regulators [Transcription]; Region: COG1378 527021002842 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 527021002843 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 527021002844 C-terminal domain interface [polypeptide binding]; other site 527021002845 sugar binding site [chemical binding]; other site 527021002846 hypothetical protein; Provisional; Region: PRK10621 527021002847 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 527021002848 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021002849 EamA-like transporter family; Region: EamA; pfam00892 527021002850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021002851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021002852 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 527021002853 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 527021002854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002855 putative substrate translocation pore; other site 527021002856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002857 hypothetical protein; Provisional; Region: PRK06770 527021002858 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 527021002859 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 527021002860 active site 527021002861 catalytic site [active] 527021002862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021002863 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 527021002864 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 527021002865 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 527021002866 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 527021002867 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 527021002868 CGNR zinc finger; Region: zf-CGNR; pfam11706 527021002869 HPP family; Region: HPP; pfam04982 527021002870 YmzC-like protein; Region: YmzC; pfam14157 527021002871 Transcriptional regulators [Transcription]; Region: MarR; COG1846 527021002872 MarR family; Region: MarR_2; pfam12802 527021002873 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 527021002874 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 527021002875 ATP synthase I chain; Region: ATP_synt_I; pfam03899 527021002876 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 527021002877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021002878 putative substrate translocation pore; other site 527021002879 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021002880 putative DNA binding site [nucleotide binding]; other site 527021002881 dimerization interface [polypeptide binding]; other site 527021002882 putative Zn2+ binding site [ion binding]; other site 527021002883 VanZ like family; Region: VanZ; pfam04892 527021002884 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 527021002885 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 527021002886 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 527021002887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021002888 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 527021002889 dihydroxyacetone kinase; Provisional; Region: PRK14479 527021002890 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 527021002891 DAK2 domain; Region: Dak2; pfam02734 527021002892 Bacterial SH3 domain; Region: SH3_3; cl17532 527021002893 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 527021002894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021002895 non-specific DNA binding site [nucleotide binding]; other site 527021002896 salt bridge; other site 527021002897 sequence-specific DNA binding site [nucleotide binding]; other site 527021002898 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021002899 transposase/IS protein; Provisional; Region: PRK09183 527021002900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021002901 Walker A motif; other site 527021002902 ATP binding site [chemical binding]; other site 527021002903 Walker B motif; other site 527021002904 arginine finger; other site 527021002905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 527021002906 Integrase core domain; Region: rve; pfam00665 527021002907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021002908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021002909 TPR motif; other site 527021002910 binding surface 527021002911 S-layer homology domain; Region: SLH; pfam00395 527021002912 S-layer homology domain; Region: SLH; pfam00395 527021002913 S-layer homology domain; Region: SLH; pfam00395 527021002914 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 527021002915 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021002916 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 527021002917 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 527021002918 Putative zinc-finger; Region: zf-HC2; pfam13490 527021002919 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 527021002920 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 527021002921 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021002922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021002923 DNA binding residues [nucleotide binding] 527021002924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021002925 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 527021002926 Heat induced stress protein YflT; Region: YflT; pfam11181 527021002927 Predicted membrane protein [Function unknown]; Region: COG2261 527021002928 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 527021002929 anti sigma factor interaction site; other site 527021002930 regulatory phosphorylation site [posttranslational modification]; other site 527021002931 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 527021002932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021002933 ATP binding site [chemical binding]; other site 527021002934 Mg2+ binding site [ion binding]; other site 527021002935 G-X-G motif; other site 527021002936 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 527021002937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021002938 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 527021002939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021002940 DNA binding residues [nucleotide binding] 527021002941 Ferritin-like domain; Region: Ferritin; pfam00210 527021002942 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 527021002943 dinuclear metal binding motif [ion binding]; other site 527021002944 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 527021002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021002946 active site 527021002947 phosphorylation site [posttranslational modification] 527021002948 intermolecular recognition site; other site 527021002949 dimerization interface [polypeptide binding]; other site 527021002950 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 527021002951 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 527021002952 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 527021002953 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 527021002954 CHASE3 domain; Region: CHASE3; pfam05227 527021002955 GAF domain; Region: GAF_2; pfam13185 527021002956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021002957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021002958 dimer interface [polypeptide binding]; other site 527021002959 phosphorylation site [posttranslational modification] 527021002960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021002961 ATP binding site [chemical binding]; other site 527021002962 Mg2+ binding site [ion binding]; other site 527021002963 G-X-G motif; other site 527021002964 Response regulator receiver domain; Region: Response_reg; pfam00072 527021002965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021002966 active site 527021002967 phosphorylation site [posttranslational modification] 527021002968 intermolecular recognition site; other site 527021002969 dimerization interface [polypeptide binding]; other site 527021002970 regulatory protein interface [polypeptide binding]; other site 527021002971 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 527021002972 regulatory phosphorylation site [posttranslational modification]; other site 527021002973 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 527021002974 hypothetical protein; Provisional; Region: PRK12856 527021002975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 527021002976 Helix-turn-helix domain; Region: HTH_28; pfam13518 527021002977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 527021002978 Transposase; Region: HTH_Tnp_1; cl17663 527021002979 Helix-turn-helix domain; Region: HTH_28; pfam13518 527021002980 putative transposase OrfB; Reviewed; Region: PHA02517 527021002981 HTH-like domain; Region: HTH_21; pfam13276 527021002982 Integrase core domain; Region: rve; pfam00665 527021002983 Integrase core domain; Region: rve_2; pfam13333 527021002984 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 527021002985 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 527021002986 putative active site [active] 527021002987 putative NTP binding site [chemical binding]; other site 527021002988 putative nucleic acid binding site [nucleotide binding]; other site 527021002989 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 527021002990 active site 527021002991 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 527021002992 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 527021002993 NADP binding site [chemical binding]; other site 527021002994 dimer interface [polypeptide binding]; other site 527021002995 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 527021002996 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 527021002997 active site 527021002998 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 527021002999 YhzD-like protein; Region: YhzD; pfam14120 527021003000 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 527021003001 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021003002 active site 527021003003 metal binding site [ion binding]; metal-binding site 527021003004 DNA binding site [nucleotide binding] 527021003005 AAA domain; Region: AAA_27; pfam13514 527021003006 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 527021003007 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 527021003008 generic binding surface II; other site 527021003009 generic binding surface I; other site 527021003010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021003011 Zn2+ binding site [ion binding]; other site 527021003012 Mg2+ binding site [ion binding]; other site 527021003013 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 527021003014 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 527021003015 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 527021003016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021003017 Zn binding site [ion binding]; other site 527021003018 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 527021003019 Zn binding site [ion binding]; other site 527021003020 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 527021003021 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021003022 Zn binding site [ion binding]; other site 527021003023 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 527021003024 Zn binding site [ion binding]; other site 527021003025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 527021003026 TPR motif; other site 527021003027 binding surface 527021003028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021003029 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 527021003030 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 527021003031 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 527021003032 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 527021003033 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 527021003034 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 527021003035 Cupin; Region: Cupin_1; smart00835 527021003036 Cupin; Region: Cupin_1; smart00835 527021003037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021003038 non-specific DNA binding site [nucleotide binding]; other site 527021003039 salt bridge; other site 527021003040 sequence-specific DNA binding site [nucleotide binding]; other site 527021003041 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 527021003042 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 527021003043 amphipathic channel; other site 527021003044 Asn-Pro-Ala signature motifs; other site 527021003045 glycerol kinase; Provisional; Region: glpK; PRK00047 527021003046 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 527021003047 N- and C-terminal domain interface [polypeptide binding]; other site 527021003048 active site 527021003049 MgATP binding site [chemical binding]; other site 527021003050 catalytic site [active] 527021003051 metal binding site [ion binding]; metal-binding site 527021003052 glycerol binding site [chemical binding]; other site 527021003053 homotetramer interface [polypeptide binding]; other site 527021003054 homodimer interface [polypeptide binding]; other site 527021003055 FBP binding site [chemical binding]; other site 527021003056 protein IIAGlc interface [polypeptide binding]; other site 527021003057 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 527021003058 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021003059 Transcriptional regulator PadR-like family; Region: PadR; cl17335 527021003060 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 527021003061 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021003062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021003063 DNA binding residues [nucleotide binding] 527021003064 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 527021003065 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021003066 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 527021003067 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 527021003068 Part of AAA domain; Region: AAA_19; pfam13245 527021003069 Family description; Region: UvrD_C_2; pfam13538 527021003070 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 527021003071 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 527021003072 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 527021003073 transcriptional regulator Hpr; Provisional; Region: PRK13777 527021003074 MarR family; Region: MarR; pfam01047 527021003075 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 527021003076 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 527021003077 HIT family signature motif; other site 527021003078 catalytic residue [active] 527021003079 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 527021003080 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021003081 Walker A/P-loop; other site 527021003082 ATP binding site [chemical binding]; other site 527021003083 Q-loop/lid; other site 527021003084 ABC transporter signature motif; other site 527021003085 Walker B; other site 527021003086 D-loop; other site 527021003087 H-loop/switch region; other site 527021003088 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 527021003089 EcsC protein family; Region: EcsC; pfam12787 527021003090 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 527021003091 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 527021003092 nucleophilic elbow; other site 527021003093 catalytic triad; other site 527021003094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021003095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021003096 Uncharacterized conserved protein [Function unknown]; Region: COG3402 527021003097 Predicted membrane protein [Function unknown]; Region: COG3428 527021003098 Bacterial PH domain; Region: DUF304; pfam03703 527021003099 Bacterial PH domain; Region: DUF304; cl01348 527021003100 Bacterial PH domain; Region: DUF304; pfam03703 527021003101 Protein of unknown function (DUF975); Region: DUF975; cl10504 527021003102 Protein of unknown function (DUF975); Region: DUF975; cl10504 527021003103 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 527021003104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021003105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021003106 Collagen binding domain; Region: Collagen_bind; pfam05737 527021003107 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021003108 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003109 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003110 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003111 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 527021003112 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003113 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003114 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003115 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003116 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003117 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003118 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003119 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003120 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003121 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003122 Cna protein B-type domain; Region: Cna_B; pfam05738 527021003123 Cornifin (SPRR) family; Region: Cornifin; pfam02389 527021003124 Biofilm formation and stress response factor; Region: BsmA; pfam10014 527021003125 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 527021003126 classical (c) SDRs; Region: SDR_c; cd05233 527021003127 NAD(P) binding site [chemical binding]; other site 527021003128 active site 527021003129 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 527021003130 EamA-like transporter family; Region: EamA; pfam00892 527021003131 EamA-like transporter family; Region: EamA; pfam00892 527021003132 Uncharacterized conserved protein [Function unknown]; Region: COG3402 527021003133 Predicted membrane protein [Function unknown]; Region: COG3428 527021003134 Bacterial PH domain; Region: DUF304; pfam03703 527021003135 Bacterial PH domain; Region: DUF304; pfam03703 527021003136 Bacterial PH domain; Region: DUF304; pfam03703 527021003137 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 527021003138 Transglycosylase; Region: Transgly; pfam00912 527021003139 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 527021003140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021003141 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 527021003142 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 527021003143 substrate binding site [chemical binding]; other site 527021003144 active site 527021003145 ferrochelatase; Provisional; Region: PRK12435 527021003146 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 527021003147 C-terminal domain interface [polypeptide binding]; other site 527021003148 active site 527021003149 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 527021003150 active site 527021003151 N-terminal domain interface [polypeptide binding]; other site 527021003152 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 527021003153 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 527021003154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 527021003155 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 527021003156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 527021003157 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 527021003158 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 527021003159 generic binding surface I; other site 527021003160 generic binding surface II; other site 527021003161 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 527021003162 putative active site [active] 527021003163 putative catalytic site [active] 527021003164 putative Mg binding site IVb [ion binding]; other site 527021003165 putative phosphate binding site [ion binding]; other site 527021003166 putative DNA binding site [nucleotide binding]; other site 527021003167 putative Mg binding site IVa [ion binding]; other site 527021003168 Penicillinase repressor; Region: Pencillinase_R; pfam03965 527021003169 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 527021003170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021003171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021003172 Predicted membrane protein [Function unknown]; Region: COG1511 527021003173 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 527021003174 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 527021003175 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 527021003176 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 527021003177 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 527021003178 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 527021003179 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021003180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021003181 Coenzyme A binding pocket [chemical binding]; other site 527021003182 Transcriptional regulators [Transcription]; Region: PurR; COG1609 527021003183 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 527021003184 DNA binding site [nucleotide binding] 527021003185 domain linker motif; other site 527021003186 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 527021003187 putative dimerization interface [polypeptide binding]; other site 527021003188 putative ligand binding site [chemical binding]; other site 527021003189 YhfH-like protein; Region: YhfH; pfam14149 527021003190 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 527021003191 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 527021003192 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 527021003193 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 527021003194 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 527021003195 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 527021003196 acyl-activating enzyme (AAE) consensus motif; other site 527021003197 putative AMP binding site [chemical binding]; other site 527021003198 putative active site [active] 527021003199 putative CoA binding site [chemical binding]; other site 527021003200 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 527021003201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 527021003202 substrate binding pocket [chemical binding]; other site 527021003203 membrane-bound complex binding site; other site 527021003204 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 527021003205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021003206 dimer interface [polypeptide binding]; other site 527021003207 conserved gate region; other site 527021003208 putative PBP binding loops; other site 527021003209 ABC-ATPase subunit interface; other site 527021003210 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 527021003211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021003212 dimer interface [polypeptide binding]; other site 527021003213 conserved gate region; other site 527021003214 putative PBP binding loops; other site 527021003215 ABC-ATPase subunit interface; other site 527021003216 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 527021003217 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 527021003218 Walker A/P-loop; other site 527021003219 ATP binding site [chemical binding]; other site 527021003220 Q-loop/lid; other site 527021003221 ABC transporter signature motif; other site 527021003222 Walker B; other site 527021003223 D-loop; other site 527021003224 H-loop/switch region; other site 527021003225 TOBE-like domain; Region: TOBE_3; pfam12857 527021003226 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 527021003227 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 527021003228 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021003229 putative active site [active] 527021003230 putative metal binding site [ion binding]; other site 527021003231 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 527021003232 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021003233 Zn2+ binding site [ion binding]; other site 527021003234 Mg2+ binding site [ion binding]; other site 527021003235 Putative zinc-finger; Region: zf-HC2; pfam13490 527021003236 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 527021003237 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 527021003238 RNA polymerase sigma factor; Provisional; Region: PRK12541 527021003239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021003240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021003241 DNA binding residues [nucleotide binding] 527021003242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021003243 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 527021003244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021003245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 527021003246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021003247 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021003248 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021003249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021003250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021003251 dimer interface [polypeptide binding]; other site 527021003252 phosphorylation site [posttranslational modification] 527021003253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021003254 ATP binding site [chemical binding]; other site 527021003255 Mg2+ binding site [ion binding]; other site 527021003256 G-X-G motif; other site 527021003257 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021003258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021003259 active site 527021003260 phosphorylation site [posttranslational modification] 527021003261 intermolecular recognition site; other site 527021003262 dimerization interface [polypeptide binding]; other site 527021003263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021003264 DNA binding site [nucleotide binding] 527021003265 CAAX protease self-immunity; Region: Abi; pfam02517 527021003266 Peptidase family M48; Region: Peptidase_M48; pfam01435 527021003267 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 527021003268 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021003269 dimerization interface [polypeptide binding]; other site 527021003270 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021003271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021003272 dimer interface [polypeptide binding]; other site 527021003273 putative CheW interface [polypeptide binding]; other site 527021003274 S-layer homology domain; Region: SLH; pfam00395 527021003275 S-layer homology domain; Region: SLH; pfam00395 527021003276 S-layer homology domain; Region: SLH; pfam00395 527021003277 S-layer homology domain; Region: SLH; pfam00395 527021003278 S-layer homology domain; Region: SLH; pfam00395 527021003279 S-layer homology domain; Region: SLH; pfam00395 527021003280 malate synthase A; Region: malate_syn_A; TIGR01344 527021003281 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 527021003282 active site 527021003283 isocitrate lyase; Provisional; Region: PRK15063 527021003284 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 527021003285 tetramer interface [polypeptide binding]; other site 527021003286 active site 527021003287 Mg2+/Mn2+ binding site [ion binding]; other site 527021003288 Phosphotransferase enzyme family; Region: APH; pfam01636 527021003289 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 527021003290 active site 527021003291 substrate binding site [chemical binding]; other site 527021003292 ATP binding site [chemical binding]; other site 527021003293 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 527021003294 DNA-binding site [nucleotide binding]; DNA binding site 527021003295 RNA-binding motif; other site 527021003296 ComK protein; Region: ComK; pfam06338 527021003297 Uncharacterized conserved protein [Function unknown]; Region: COG0398 527021003298 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 527021003299 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 527021003300 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021003301 Catalytic site [active] 527021003302 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021003303 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 527021003304 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 527021003305 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 527021003306 Part of AAA domain; Region: AAA_19; pfam13245 527021003307 Family description; Region: UvrD_C_2; pfam13538 527021003308 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 527021003309 hypothetical protein; Provisional; Region: PRK07758 527021003310 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 527021003311 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 527021003312 Spore germination protein GerPC; Region: GerPC; pfam10737 527021003313 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 527021003314 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 527021003315 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 527021003316 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 527021003317 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 527021003318 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 527021003319 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 527021003320 inhibitor-cofactor binding pocket; inhibition site 527021003321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021003322 catalytic residue [active] 527021003323 hypothetical protein; Provisional; Region: PRK13673 527021003324 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 527021003325 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 527021003326 active site 527021003327 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 527021003328 dimer interface [polypeptide binding]; other site 527021003329 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 527021003330 Ligand Binding Site [chemical binding]; other site 527021003331 Molecular Tunnel; other site 527021003332 ferrochelatase; Provisional; Region: PRK12435 527021003333 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 527021003334 C-terminal domain interface [polypeptide binding]; other site 527021003335 active site 527021003336 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 527021003337 active site 527021003338 N-terminal domain interface [polypeptide binding]; other site 527021003339 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 527021003340 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 527021003341 tetramer interface [polypeptide binding]; other site 527021003342 heme binding pocket [chemical binding]; other site 527021003343 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 527021003344 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 527021003345 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 527021003346 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 527021003347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021003348 non-specific DNA binding site [nucleotide binding]; other site 527021003349 salt bridge; other site 527021003350 sequence-specific DNA binding site [nucleotide binding]; other site 527021003351 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021003352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 527021003353 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 527021003354 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 527021003355 S1 domain; Region: S1_2; pfam13509 527021003356 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 527021003357 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 527021003358 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021003359 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021003360 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021003361 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 527021003362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021003363 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 527021003364 active site 527021003365 motif I; other site 527021003366 motif II; other site 527021003367 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 527021003368 YjzC-like protein; Region: YjzC; pfam14168 527021003369 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 527021003370 Clp amino terminal domain; Region: Clp_N; pfam02861 527021003371 Clp amino terminal domain; Region: Clp_N; pfam02861 527021003372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021003373 Walker A motif; other site 527021003374 ATP binding site [chemical binding]; other site 527021003375 Walker B motif; other site 527021003376 arginine finger; other site 527021003377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021003378 Walker A motif; other site 527021003379 ATP binding site [chemical binding]; other site 527021003380 Walker B motif; other site 527021003381 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 527021003382 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 527021003383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021003384 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 527021003385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021003386 NAD(P) binding site [chemical binding]; other site 527021003387 active site 527021003388 ComZ; Region: ComZ; pfam10815 527021003389 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 527021003390 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 527021003391 dimer interface [polypeptide binding]; other site 527021003392 active site 527021003393 CoA binding pocket [chemical binding]; other site 527021003394 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 527021003395 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 527021003396 dimer interface [polypeptide binding]; other site 527021003397 active site 527021003398 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 527021003399 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 527021003400 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 527021003401 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 527021003402 active site 527021003403 HIGH motif; other site 527021003404 dimer interface [polypeptide binding]; other site 527021003405 KMSKS motif; other site 527021003406 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 527021003407 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021003408 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021003409 peptide binding site [polypeptide binding]; other site 527021003410 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 527021003411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021003412 dimer interface [polypeptide binding]; other site 527021003413 conserved gate region; other site 527021003414 putative PBP binding loops; other site 527021003415 ABC-ATPase subunit interface; other site 527021003416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 527021003417 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 527021003418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021003419 dimer interface [polypeptide binding]; other site 527021003420 conserved gate region; other site 527021003421 putative PBP binding loops; other site 527021003422 ABC-ATPase subunit interface; other site 527021003423 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 527021003424 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021003425 Walker A/P-loop; other site 527021003426 ATP binding site [chemical binding]; other site 527021003427 Q-loop/lid; other site 527021003428 ABC transporter signature motif; other site 527021003429 Walker B; other site 527021003430 D-loop; other site 527021003431 H-loop/switch region; other site 527021003432 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 527021003433 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 527021003434 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 527021003435 Walker A/P-loop; other site 527021003436 ATP binding site [chemical binding]; other site 527021003437 Q-loop/lid; other site 527021003438 ABC transporter signature motif; other site 527021003439 Walker B; other site 527021003440 D-loop; other site 527021003441 H-loop/switch region; other site 527021003442 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 527021003443 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 527021003444 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 527021003445 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021003446 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021003447 peptide binding site [polypeptide binding]; other site 527021003448 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 527021003449 ArsC family; Region: ArsC; pfam03960 527021003450 putative catalytic residues [active] 527021003451 thiol/disulfide switch; other site 527021003452 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 527021003453 adaptor protein; Provisional; Region: PRK02315 527021003454 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 527021003455 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 527021003456 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 527021003457 putative active site [active] 527021003458 catalytic site [active] 527021003459 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 527021003460 putative active site [active] 527021003461 catalytic site [active] 527021003462 Competence protein CoiA-like family; Region: CoiA; cl11541 527021003463 oligoendopeptidase F; Region: pepF; TIGR00181 527021003464 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 527021003465 active site 527021003466 Zn binding site [ion binding]; other site 527021003467 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 527021003468 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 527021003469 catalytic residues [active] 527021003470 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 527021003471 apolar tunnel; other site 527021003472 heme binding site [chemical binding]; other site 527021003473 dimerization interface [polypeptide binding]; other site 527021003474 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 527021003475 putative active site [active] 527021003476 putative metal binding residues [ion binding]; other site 527021003477 signature motif; other site 527021003478 putative triphosphate binding site [ion binding]; other site 527021003479 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 527021003480 synthetase active site [active] 527021003481 NTP binding site [chemical binding]; other site 527021003482 metal binding site [ion binding]; metal-binding site 527021003483 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 527021003484 ATP-NAD kinase; Region: NAD_kinase; pfam01513 527021003485 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 527021003486 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 527021003487 active site 527021003488 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 527021003489 trimer interface [polypeptide binding]; other site 527021003490 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 527021003491 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 527021003492 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 527021003493 active site 527021003494 metal binding site [ion binding]; metal-binding site 527021003495 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 527021003496 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 527021003497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 527021003498 active site 527021003499 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021003500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021003501 S-adenosylmethionine binding site [chemical binding]; other site 527021003502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 527021003503 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 527021003504 putative metal binding site; other site 527021003505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021003506 binding surface 527021003507 TPR motif; other site 527021003508 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021003509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021003510 S-adenosylmethionine binding site [chemical binding]; other site 527021003511 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 527021003512 catalytic residues [active] 527021003513 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 527021003514 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 527021003515 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 527021003516 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 527021003517 active site 527021003518 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 527021003519 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 527021003520 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 527021003521 NAD binding site [chemical binding]; other site 527021003522 substrate binding site [chemical binding]; other site 527021003523 homodimer interface [polypeptide binding]; other site 527021003524 active site 527021003525 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 527021003526 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 527021003527 NADP binding site [chemical binding]; other site 527021003528 active site 527021003529 putative substrate binding site [chemical binding]; other site 527021003530 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 527021003531 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 527021003532 NAD binding site [chemical binding]; other site 527021003533 homotetramer interface [polypeptide binding]; other site 527021003534 homodimer interface [polypeptide binding]; other site 527021003535 substrate binding site [chemical binding]; other site 527021003536 active site 527021003537 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 527021003538 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 527021003539 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 527021003540 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 527021003541 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 527021003542 Part of AAA domain; Region: AAA_19; pfam13245 527021003543 Family description; Region: UvrD_C_2; pfam13538 527021003544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021003545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021003546 Coenzyme A binding pocket [chemical binding]; other site 527021003547 hypothetical protein; Provisional; Region: PRK13679 527021003548 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 527021003549 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 527021003550 Putative esterase; Region: Esterase; pfam00756 527021003551 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 527021003552 EamA-like transporter family; Region: EamA; pfam00892 527021003553 EamA-like transporter family; Region: EamA; pfam00892 527021003554 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 527021003555 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 527021003556 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 527021003557 Na binding site [ion binding]; other site 527021003558 anthranilate synthase component I; Provisional; Region: PRK13570 527021003559 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 527021003560 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 527021003561 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 527021003562 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 527021003563 glutamine binding [chemical binding]; other site 527021003564 catalytic triad [active] 527021003565 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 527021003566 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 527021003567 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 527021003568 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 527021003569 active site 527021003570 ribulose/triose binding site [chemical binding]; other site 527021003571 phosphate binding site [ion binding]; other site 527021003572 substrate (anthranilate) binding pocket [chemical binding]; other site 527021003573 product (indole) binding pocket [chemical binding]; other site 527021003574 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 527021003575 active site 527021003576 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 527021003577 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 527021003578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021003579 catalytic residue [active] 527021003580 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 527021003581 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 527021003582 substrate binding site [chemical binding]; other site 527021003583 active site 527021003584 catalytic residues [active] 527021003585 heterodimer interface [polypeptide binding]; other site 527021003586 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 527021003587 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 527021003588 L-lactate permease; Region: Lactate_perm; cl00701 527021003589 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 527021003590 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 527021003591 Double zinc ribbon; Region: DZR; pfam12773 527021003592 Predicted membrane protein [Function unknown]; Region: COG4640 527021003593 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 527021003594 YARHG domain; Region: YARHG; pfam13308 527021003595 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 527021003596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 527021003597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021003598 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 527021003599 Predicted acetyltransferase [General function prediction only]; Region: COG5628 527021003600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021003601 Coenzyme A binding pocket [chemical binding]; other site 527021003602 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 527021003603 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021003604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021003605 S-adenosylmethionine binding site [chemical binding]; other site 527021003606 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 527021003607 NADPH bind site [chemical binding]; other site 527021003608 putative FMN binding site [chemical binding]; other site 527021003609 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 527021003610 putative FMN binding site [chemical binding]; other site 527021003611 NADPH bind site [chemical binding]; other site 527021003612 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 527021003613 YcaO-like family; Region: YcaO; pfam02624 527021003614 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 527021003615 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 527021003616 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 527021003617 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 527021003618 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 527021003619 E3 interaction surface; other site 527021003620 lipoyl attachment site [posttranslational modification]; other site 527021003621 e3 binding domain; Region: E3_binding; pfam02817 527021003622 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 527021003623 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 527021003624 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 527021003625 TPP-binding site [chemical binding]; other site 527021003626 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 527021003627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021003628 salt bridge; other site 527021003629 non-specific DNA binding site [nucleotide binding]; other site 527021003630 sequence-specific DNA binding site [nucleotide binding]; other site 527021003631 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 527021003632 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 527021003633 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 527021003634 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 527021003635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021003636 S-adenosylmethionine binding site [chemical binding]; other site 527021003637 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 527021003638 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021003639 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 527021003640 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 527021003641 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021003642 Catalytic site [active] 527021003643 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 527021003644 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 527021003645 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 527021003646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021003647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021003648 non-specific DNA binding site [nucleotide binding]; other site 527021003649 salt bridge; other site 527021003650 sequence-specific DNA binding site [nucleotide binding]; other site 527021003651 Anti-repressor SinI; Region: SinI; pfam08671 527021003652 Anti-repressor SinI; Region: SinI; pfam08671 527021003653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 527021003654 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 527021003655 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 527021003656 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 527021003657 NAD(P) binding site [chemical binding]; other site 527021003658 catalytic residues [active] 527021003659 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 527021003660 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 527021003661 Walker A/P-loop; other site 527021003662 ATP binding site [chemical binding]; other site 527021003663 Q-loop/lid; other site 527021003664 ABC transporter signature motif; other site 527021003665 Walker B; other site 527021003666 D-loop; other site 527021003667 H-loop/switch region; other site 527021003668 TOBE domain; Region: TOBE_2; pfam08402 527021003669 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 527021003670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021003671 dimer interface [polypeptide binding]; other site 527021003672 conserved gate region; other site 527021003673 putative PBP binding loops; other site 527021003674 ABC-ATPase subunit interface; other site 527021003675 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 527021003676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021003677 dimer interface [polypeptide binding]; other site 527021003678 conserved gate region; other site 527021003679 putative PBP binding loops; other site 527021003680 ABC-ATPase subunit interface; other site 527021003681 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 527021003682 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 527021003683 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 527021003684 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 527021003685 active site 527021003686 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 527021003687 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 527021003688 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 527021003689 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 527021003690 active site 527021003691 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 527021003692 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 527021003693 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 527021003694 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 527021003695 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 527021003696 Cysteine-rich domain; Region: CCG; pfam02754 527021003697 Cysteine-rich domain; Region: CCG; pfam02754 527021003698 FAD binding domain; Region: FAD_binding_4; pfam01565 527021003699 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 527021003700 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 527021003701 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 527021003702 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 527021003703 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 527021003704 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 527021003705 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021003706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021003707 active site 527021003708 phosphorylation site [posttranslational modification] 527021003709 intermolecular recognition site; other site 527021003710 dimerization interface [polypeptide binding]; other site 527021003711 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021003712 DNA binding site [nucleotide binding] 527021003713 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 527021003714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021003715 dimerization interface [polypeptide binding]; other site 527021003716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021003717 dimer interface [polypeptide binding]; other site 527021003718 phosphorylation site [posttranslational modification] 527021003719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021003720 ATP binding site [chemical binding]; other site 527021003721 Mg2+ binding site [ion binding]; other site 527021003722 G-X-G motif; other site 527021003723 Transcriptional regulators [Transcription]; Region: FadR; COG2186 527021003724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021003725 DNA-binding site [nucleotide binding]; DNA binding site 527021003726 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 527021003727 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 527021003728 Cysteine-rich domain; Region: CCG; pfam02754 527021003729 Cysteine-rich domain; Region: CCG; pfam02754 527021003730 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 527021003731 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 527021003732 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 527021003733 Uncharacterized conserved protein [Function unknown]; Region: COG1556 527021003734 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 527021003735 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 527021003736 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 527021003737 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 527021003738 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 527021003739 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 527021003740 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 527021003741 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 527021003742 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 527021003743 dimer interaction site [polypeptide binding]; other site 527021003744 substrate-binding tunnel; other site 527021003745 active site 527021003746 catalytic site [active] 527021003747 substrate binding site [chemical binding]; other site 527021003748 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 527021003749 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 527021003750 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021003751 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 527021003752 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 527021003753 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 527021003754 NAD(P) binding site [chemical binding]; other site 527021003755 homotetramer interface [polypeptide binding]; other site 527021003756 homodimer interface [polypeptide binding]; other site 527021003757 active site 527021003758 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 527021003759 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 527021003760 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 527021003761 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 527021003762 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 527021003763 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 527021003764 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 527021003765 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 527021003766 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 527021003767 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 527021003768 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 527021003769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021003770 Walker A/P-loop; other site 527021003771 ATP binding site [chemical binding]; other site 527021003772 Q-loop/lid; other site 527021003773 ABC transporter signature motif; other site 527021003774 Walker B; other site 527021003775 D-loop; other site 527021003776 H-loop/switch region; other site 527021003777 TOBE domain; Region: TOBE_2; pfam08402 527021003778 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 527021003779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021003780 dimer interface [polypeptide binding]; other site 527021003781 conserved gate region; other site 527021003782 putative PBP binding loops; other site 527021003783 ABC-ATPase subunit interface; other site 527021003784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021003785 dimer interface [polypeptide binding]; other site 527021003786 conserved gate region; other site 527021003787 putative PBP binding loops; other site 527021003788 ABC-ATPase subunit interface; other site 527021003789 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 527021003790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021003791 motif II; other site 527021003792 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 527021003793 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021003794 catalytic residue [active] 527021003795 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 527021003796 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 527021003797 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 527021003798 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 527021003799 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 527021003800 heme-binding site [chemical binding]; other site 527021003801 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021003802 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 527021003803 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021003804 Leucine-rich repeats; other site 527021003805 Substrate binding site [chemical binding]; other site 527021003806 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021003807 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021003808 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021003809 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021003810 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021003811 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 527021003812 LRR adjacent; Region: LRR_adjacent; pfam08191 527021003813 S-layer homology domain; Region: SLH; pfam00395 527021003814 S-layer homology domain; Region: SLH; pfam00395 527021003815 S-layer homology domain; Region: SLH; pfam00395 527021003816 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 527021003817 intersubunit interface [polypeptide binding]; other site 527021003818 active site 527021003819 Zn2+ binding site [ion binding]; other site 527021003820 FOG: CBS domain [General function prediction only]; Region: COG0517 527021003821 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 527021003822 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 527021003823 NodB motif; other site 527021003824 putative active site [active] 527021003825 putative catalytic site [active] 527021003826 Zn binding site [ion binding]; other site 527021003827 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 527021003828 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 527021003829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021003830 dimer interface [polypeptide binding]; other site 527021003831 phosphorylation site [posttranslational modification] 527021003832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021003833 ATP binding site [chemical binding]; other site 527021003834 Mg2+ binding site [ion binding]; other site 527021003835 G-X-G motif; other site 527021003836 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021003837 MarR family; Region: MarR; pfam01047 527021003838 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 527021003839 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 527021003840 active site 527021003841 Zn binding site [ion binding]; other site 527021003842 DinB superfamily; Region: DinB_2; pfam12867 527021003843 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 527021003844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021003845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021003846 dimer interface [polypeptide binding]; other site 527021003847 phosphorylation site [posttranslational modification] 527021003848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021003849 ATP binding site [chemical binding]; other site 527021003850 Mg2+ binding site [ion binding]; other site 527021003851 G-X-G motif; other site 527021003852 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 527021003853 Ligand Binding Site [chemical binding]; other site 527021003854 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 527021003855 active site 527021003856 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 527021003857 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 527021003858 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 527021003859 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 527021003860 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 527021003861 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021003862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021003863 Coenzyme A binding pocket [chemical binding]; other site 527021003864 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 527021003865 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 527021003866 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 527021003867 Class I ribonucleotide reductase; Region: RNR_I; cd01679 527021003868 active site 527021003869 dimer interface [polypeptide binding]; other site 527021003870 catalytic residues [active] 527021003871 effector binding site; other site 527021003872 R2 peptide binding site; other site 527021003873 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 527021003874 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 527021003875 dimer interface [polypeptide binding]; other site 527021003876 putative radical transfer pathway; other site 527021003877 diiron center [ion binding]; other site 527021003878 tyrosyl radical; other site 527021003879 Predicted transcriptional regulators [Transcription]; Region: COG1725 527021003880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021003881 DNA-binding site [nucleotide binding]; DNA binding site 527021003882 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 527021003883 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021003884 Walker A/P-loop; other site 527021003885 ATP binding site [chemical binding]; other site 527021003886 Q-loop/lid; other site 527021003887 ABC transporter signature motif; other site 527021003888 Walker B; other site 527021003889 D-loop; other site 527021003890 H-loop/switch region; other site 527021003891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021003892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021003893 Walker A/P-loop; other site 527021003894 ATP binding site [chemical binding]; other site 527021003895 Q-loop/lid; other site 527021003896 ABC transporter signature motif; other site 527021003897 Walker B; other site 527021003898 D-loop; other site 527021003899 H-loop/switch region; other site 527021003900 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 527021003901 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 527021003902 CAAX protease self-immunity; Region: Abi; pfam02517 527021003903 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 527021003904 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 527021003905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021003906 putative DNA binding site [nucleotide binding]; other site 527021003907 putative Zn2+ binding site [ion binding]; other site 527021003908 AsnC family; Region: AsnC_trans_reg; pfam01037 527021003909 Uncharacterized conserved protein [Function unknown]; Region: COG2128 527021003910 Isochorismatase family; Region: Isochorismatase; pfam00857 527021003911 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 527021003912 catalytic triad [active] 527021003913 conserved cis-peptide bond; other site 527021003914 SseB protein; Region: SseB; cl06279 527021003915 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 527021003916 dimer interface [polypeptide binding]; other site 527021003917 catalytic triad [active] 527021003918 Nitronate monooxygenase; Region: NMO; pfam03060 527021003919 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 527021003920 FMN binding site [chemical binding]; other site 527021003921 substrate binding site [chemical binding]; other site 527021003922 putative catalytic residue [active] 527021003923 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 527021003924 DltD N-terminal region; Region: DltD_N; pfam04915 527021003925 DltD central region; Region: DltD_M; pfam04918 527021003926 DltD C-terminal region; Region: DltD_C; pfam04914 527021003927 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 527021003928 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 527021003929 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 527021003930 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 527021003931 acyl-activating enzyme (AAE) consensus motif; other site 527021003932 AMP binding site [chemical binding]; other site 527021003933 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 527021003934 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 527021003935 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 527021003936 metal binding site [ion binding]; metal-binding site 527021003937 dimer interface [polypeptide binding]; other site 527021003938 flavodoxin; Provisional; Region: PRK06756 527021003939 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 527021003940 Phosphotransferase enzyme family; Region: APH; pfam01636 527021003941 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 527021003942 active site 527021003943 substrate binding site [chemical binding]; other site 527021003944 ATP binding site [chemical binding]; other site 527021003945 multidrug efflux protein; Reviewed; Region: PRK01766 527021003946 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 527021003947 cation binding site [ion binding]; other site 527021003948 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 527021003949 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 527021003950 Regulatory protein YrvL; Region: YrvL; pfam14184 527021003951 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021003952 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 527021003953 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 527021003954 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 527021003955 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 527021003956 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 527021003957 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 527021003958 hypothetical protein; Provisional; Region: PRK03094 527021003959 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 527021003960 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 527021003961 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 527021003962 homodimer interface [polypeptide binding]; other site 527021003963 substrate-cofactor binding pocket; other site 527021003964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021003965 catalytic residue [active] 527021003966 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 527021003967 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 527021003968 PYR/PP interface [polypeptide binding]; other site 527021003969 dimer interface [polypeptide binding]; other site 527021003970 TPP binding site [chemical binding]; other site 527021003971 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 527021003972 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 527021003973 TPP-binding site [chemical binding]; other site 527021003974 dimer interface [polypeptide binding]; other site 527021003975 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 527021003976 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 527021003977 putative valine binding site [chemical binding]; other site 527021003978 dimer interface [polypeptide binding]; other site 527021003979 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 527021003980 ketol-acid reductoisomerase; Provisional; Region: PRK05479 527021003981 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 527021003982 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 527021003983 2-isopropylmalate synthase; Validated; Region: PRK00915 527021003984 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 527021003985 active site 527021003986 catalytic residues [active] 527021003987 metal binding site [ion binding]; metal-binding site 527021003988 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 527021003989 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 527021003990 tartrate dehydrogenase; Region: TTC; TIGR02089 527021003991 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 527021003992 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 527021003993 substrate binding site [chemical binding]; other site 527021003994 ligand binding site [chemical binding]; other site 527021003995 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 527021003996 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 527021003997 substrate binding site [chemical binding]; other site 527021003998 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 527021003999 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 527021004000 dimer interface [polypeptide binding]; other site 527021004001 motif 1; other site 527021004002 active site 527021004003 motif 2; other site 527021004004 motif 3; other site 527021004005 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 527021004006 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 527021004007 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 527021004008 histidinol dehydrogenase; Region: hisD; TIGR00069 527021004009 NAD binding site [chemical binding]; other site 527021004010 dimerization interface [polypeptide binding]; other site 527021004011 product binding site; other site 527021004012 substrate binding site [chemical binding]; other site 527021004013 zinc binding site [ion binding]; other site 527021004014 catalytic residues [active] 527021004015 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 527021004016 putative active site pocket [active] 527021004017 4-fold oligomerization interface [polypeptide binding]; other site 527021004018 metal binding residues [ion binding]; metal-binding site 527021004019 3-fold/trimer interface [polypeptide binding]; other site 527021004020 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 527021004021 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 527021004022 putative active site [active] 527021004023 oxyanion strand; other site 527021004024 catalytic triad [active] 527021004025 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 527021004026 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 527021004027 catalytic residues [active] 527021004028 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 527021004029 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 527021004030 substrate binding site [chemical binding]; other site 527021004031 glutamase interaction surface [polypeptide binding]; other site 527021004032 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 527021004033 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 527021004034 metal binding site [ion binding]; metal-binding site 527021004035 histidinol-phosphatase; Validated; Region: PRK06740 527021004036 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 527021004037 dimer interface [polypeptide binding]; other site 527021004038 active site 527021004039 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 527021004040 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 527021004041 putative ligand binding site [chemical binding]; other site 527021004042 putative NAD binding site [chemical binding]; other site 527021004043 catalytic site [active] 527021004044 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 527021004045 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 527021004046 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 527021004047 Sulfatase; Region: Sulfatase; pfam00884 527021004048 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 527021004049 diaminopimelate decarboxylase; Region: lysA; TIGR01048 527021004050 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 527021004051 active site 527021004052 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 527021004053 substrate binding site [chemical binding]; other site 527021004054 catalytic residues [active] 527021004055 dimer interface [polypeptide binding]; other site 527021004056 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 527021004057 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 527021004058 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 527021004059 Active Sites [active] 527021004060 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 527021004061 ATP-sulfurylase; Region: ATPS; cd00517 527021004062 active site 527021004063 HXXH motif; other site 527021004064 flexible loop; other site 527021004065 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 527021004066 AAA domain; Region: AAA_18; pfam13238 527021004067 ligand-binding site [chemical binding]; other site 527021004068 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 527021004069 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 527021004070 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 527021004071 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 527021004072 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 527021004073 diphthine synthase; Region: dph5; TIGR00522 527021004074 active site 527021004075 SAM binding site [chemical binding]; other site 527021004076 homodimer interface [polypeptide binding]; other site 527021004077 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 527021004078 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 527021004079 putative active site [active] 527021004080 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 527021004081 putative active site [active] 527021004082 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 527021004083 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 527021004084 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 527021004085 Na2 binding site [ion binding]; other site 527021004086 putative substrate binding site 1 [chemical binding]; other site 527021004087 Na binding site 1 [ion binding]; other site 527021004088 putative substrate binding site 2 [chemical binding]; other site 527021004089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 527021004090 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 527021004091 Peptidase family M23; Region: Peptidase_M23; pfam01551 527021004092 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 527021004093 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 527021004094 Protein of unknown function (DUF402); Region: DUF402; cl00979 527021004095 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 527021004096 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 527021004097 Vpu protein; Region: Vpu; pfam00558 527021004098 PspA/IM30 family; Region: PspA_IM30; pfam04012 527021004099 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 527021004100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 527021004101 Histidine kinase; Region: HisKA_3; pfam07730 527021004102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021004103 ATP binding site [chemical binding]; other site 527021004104 Mg2+ binding site [ion binding]; other site 527021004105 G-X-G motif; other site 527021004106 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021004108 active site 527021004109 phosphorylation site [posttranslational modification] 527021004110 intermolecular recognition site; other site 527021004111 dimerization interface [polypeptide binding]; other site 527021004112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021004113 DNA binding residues [nucleotide binding] 527021004114 dimerization interface [polypeptide binding]; other site 527021004115 Protein of unknown function (DUF3992); Region: DUF3922; pfam13059 527021004116 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 527021004117 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021004118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021004119 S-adenosylmethionine binding site [chemical binding]; other site 527021004120 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 527021004121 Peptidase family M50; Region: Peptidase_M50; pfam02163 527021004122 active site 527021004123 putative substrate binding region [chemical binding]; other site 527021004124 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 527021004125 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 527021004126 heme-binding site [chemical binding]; other site 527021004127 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 527021004128 FAD binding pocket [chemical binding]; other site 527021004129 FAD binding motif [chemical binding]; other site 527021004130 phosphate binding motif [ion binding]; other site 527021004131 beta-alpha-beta structure motif; other site 527021004132 NAD binding pocket [chemical binding]; other site 527021004133 Heme binding pocket [chemical binding]; other site 527021004134 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 527021004135 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 527021004136 ligand binding site [chemical binding]; other site 527021004137 flexible hinge region; other site 527021004138 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 527021004139 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 527021004140 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 527021004141 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 527021004142 Transglycosylase; Region: Transgly; pfam00912 527021004143 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 527021004144 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021004145 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 527021004146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 527021004147 putative active site [active] 527021004148 heme pocket [chemical binding]; other site 527021004149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021004150 dimer interface [polypeptide binding]; other site 527021004151 phosphorylation site [posttranslational modification] 527021004152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021004153 ATP binding site [chemical binding]; other site 527021004154 Mg2+ binding site [ion binding]; other site 527021004155 G-X-G motif; other site 527021004156 Protein of unknown function DUF72; Region: DUF72; pfam01904 527021004157 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 527021004158 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 527021004159 active site 527021004160 DNA binding site [nucleotide binding] 527021004161 Int/Topo IB signature motif; other site 527021004162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021004163 dimerization interface [polypeptide binding]; other site 527021004164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021004165 dimer interface [polypeptide binding]; other site 527021004166 phosphorylation site [posttranslational modification] 527021004167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021004168 ATP binding site [chemical binding]; other site 527021004169 Mg2+ binding site [ion binding]; other site 527021004170 G-X-G motif; other site 527021004171 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 527021004172 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 527021004173 Predicted integral membrane protein [Function unknown]; Region: COG0392 527021004174 Uncharacterized conserved protein [Function unknown]; Region: COG2898 527021004175 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 527021004176 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 527021004177 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 527021004178 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 527021004179 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 527021004180 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 527021004181 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021004182 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 527021004183 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 527021004184 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 527021004185 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 527021004186 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021004187 RNA binding surface [nucleotide binding]; other site 527021004188 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 527021004189 active site 527021004190 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 527021004191 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 527021004192 catalytic residues [active] 527021004193 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 527021004194 ResB-like family; Region: ResB; pfam05140 527021004195 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 527021004196 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 527021004197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021004198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021004199 active site 527021004200 phosphorylation site [posttranslational modification] 527021004201 intermolecular recognition site; other site 527021004202 dimerization interface [polypeptide binding]; other site 527021004203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021004204 DNA binding site [nucleotide binding] 527021004205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 527021004206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021004207 dimerization interface [polypeptide binding]; other site 527021004208 PAS domain; Region: PAS; smart00091 527021004209 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021004210 dimer interface [polypeptide binding]; other site 527021004211 phosphorylation site [posttranslational modification] 527021004212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021004213 ATP binding site [chemical binding]; other site 527021004214 Mg2+ binding site [ion binding]; other site 527021004215 G-X-G motif; other site 527021004216 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 527021004217 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 527021004218 Peptidase family M23; Region: Peptidase_M23; pfam01551 527021004219 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 527021004220 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021004221 Predicted membrane protein [Function unknown]; Region: COG3601 527021004222 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 527021004223 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 527021004224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 527021004225 DEAD-like helicases superfamily; Region: DEXDc; smart00487 527021004226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021004227 ATP binding site [chemical binding]; other site 527021004228 putative Mg++ binding site [ion binding]; other site 527021004229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021004230 nucleotide binding region [chemical binding]; other site 527021004231 ATP-binding site [chemical binding]; other site 527021004232 CAAX protease self-immunity; Region: Abi; pfam02517 527021004233 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021004234 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 527021004235 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021004236 putative active site [active] 527021004237 putative metal binding site [ion binding]; other site 527021004238 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021004239 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 527021004240 DNA binding residues [nucleotide binding] 527021004241 B12 binding domain; Region: B12-binding_2; pfam02607 527021004242 adaptor protein; Provisional; Region: PRK02899 527021004243 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 527021004244 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 527021004245 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 527021004246 NAD(P) binding site [chemical binding]; other site 527021004247 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 527021004248 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 527021004249 amidase catalytic site [active] 527021004250 Zn binding residues [ion binding]; other site 527021004251 substrate binding site [chemical binding]; other site 527021004252 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 527021004253 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 527021004254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021004255 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 527021004256 active site 527021004257 homodimer interface [polypeptide binding]; other site 527021004258 homotetramer interface [polypeptide binding]; other site 527021004259 cytidylate kinase; Provisional; Region: cmk; PRK00023 527021004260 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 527021004261 CMP-binding site; other site 527021004262 The sites determining sugar specificity; other site 527021004263 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 527021004264 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 527021004265 RNA binding site [nucleotide binding]; other site 527021004266 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 527021004267 RNA binding site [nucleotide binding]; other site 527021004268 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 527021004269 RNA binding site [nucleotide binding]; other site 527021004270 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 527021004271 RNA binding site [nucleotide binding]; other site 527021004272 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 527021004273 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 527021004274 homotetramer interface [polypeptide binding]; other site 527021004275 FMN binding site [chemical binding]; other site 527021004276 homodimer contacts [polypeptide binding]; other site 527021004277 putative active site [active] 527021004278 putative substrate binding site [chemical binding]; other site 527021004279 YpzI-like protein; Region: YpzI; pfam14140 527021004280 YIEGIA protein; Region: YIEGIA; pfam14045 527021004281 GTP-binding protein Der; Reviewed; Region: PRK00093 527021004282 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 527021004283 G1 box; other site 527021004284 GTP/Mg2+ binding site [chemical binding]; other site 527021004285 Switch I region; other site 527021004286 G2 box; other site 527021004287 Switch II region; other site 527021004288 G3 box; other site 527021004289 G4 box; other site 527021004290 G5 box; other site 527021004291 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 527021004292 G1 box; other site 527021004293 GTP/Mg2+ binding site [chemical binding]; other site 527021004294 Switch I region; other site 527021004295 G2 box; other site 527021004296 G3 box; other site 527021004297 Switch II region; other site 527021004298 G4 box; other site 527021004299 G5 box; other site 527021004300 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 527021004301 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 527021004302 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 527021004303 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 527021004304 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 527021004305 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 527021004306 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 527021004307 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 527021004308 IHF dimer interface [polypeptide binding]; other site 527021004309 IHF - DNA interface [nucleotide binding]; other site 527021004310 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 527021004311 homodecamer interface [polypeptide binding]; other site 527021004312 GTP cyclohydrolase I; Provisional; Region: PLN03044 527021004313 active site 527021004314 putative catalytic site residues [active] 527021004315 zinc binding site [ion binding]; other site 527021004316 GTP-CH-I/GFRP interaction surface; other site 527021004317 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 527021004318 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 527021004319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021004320 S-adenosylmethionine binding site [chemical binding]; other site 527021004321 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 527021004322 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 527021004323 substrate binding pocket [chemical binding]; other site 527021004324 chain length determination region; other site 527021004325 substrate-Mg2+ binding site; other site 527021004326 catalytic residues [active] 527021004327 aspartate-rich region 1; other site 527021004328 active site lid residues [active] 527021004329 aspartate-rich region 2; other site 527021004330 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 527021004331 active site 527021004332 multimer interface [polypeptide binding]; other site 527021004333 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 527021004334 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 527021004335 Tetramer interface [polypeptide binding]; other site 527021004336 active site 527021004337 FMN-binding site [chemical binding]; other site 527021004338 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 527021004339 active site 527021004340 dimer interface [polypeptide binding]; other site 527021004341 metal binding site [ion binding]; metal-binding site 527021004342 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 527021004343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021004344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021004345 homodimer interface [polypeptide binding]; other site 527021004346 catalytic residue [active] 527021004347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021004348 binding surface 527021004349 TPR motif; other site 527021004350 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 527021004351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021004352 binding surface 527021004353 TPR motif; other site 527021004354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021004355 binding surface 527021004356 TPR motif; other site 527021004357 hypothetical protein; Provisional; Region: PRK03636 527021004358 UPF0302 domain; Region: UPF0302; pfam08864 527021004359 IDEAL domain; Region: IDEAL; pfam08858 527021004360 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 527021004361 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 527021004362 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 527021004363 iron-sulfur cluster [ion binding]; other site 527021004364 [2Fe-2S] cluster binding site [ion binding]; other site 527021004365 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 527021004366 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 527021004367 interchain domain interface [polypeptide binding]; other site 527021004368 intrachain domain interface; other site 527021004369 heme bH binding site [chemical binding]; other site 527021004370 Qi binding site; other site 527021004371 heme bL binding site [chemical binding]; other site 527021004372 Qo binding site; other site 527021004373 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 527021004374 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 527021004375 interchain domain interface [polypeptide binding]; other site 527021004376 intrachain domain interface; other site 527021004377 Qi binding site; other site 527021004378 Qo binding site; other site 527021004379 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 527021004380 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 527021004381 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 527021004382 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 527021004383 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 527021004384 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 527021004385 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 527021004386 active site 527021004387 Fe-S cluster binding site [ion binding]; other site 527021004388 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021004389 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021004390 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021004391 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021004392 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 527021004393 homodimer interface [polypeptide binding]; other site 527021004394 metal binding site [ion binding]; metal-binding site 527021004395 dihydrodipicolinate reductase; Provisional; Region: PRK00048 527021004396 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 527021004397 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 527021004398 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 527021004399 active site 527021004400 dimer interfaces [polypeptide binding]; other site 527021004401 catalytic residues [active] 527021004402 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 527021004403 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 527021004404 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 527021004405 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 527021004406 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 527021004407 active site 527021004408 NTP binding site [chemical binding]; other site 527021004409 metal binding triad [ion binding]; metal-binding site 527021004410 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 527021004411 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 527021004412 Biotin operon repressor [Transcription]; Region: BirA; COG1654 527021004413 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 527021004414 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 527021004415 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 527021004416 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 527021004417 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 527021004418 oligomerization interface [polypeptide binding]; other site 527021004419 active site 527021004420 metal binding site [ion binding]; metal-binding site 527021004421 pantoate--beta-alanine ligase; Region: panC; TIGR00018 527021004422 Pantoate-beta-alanine ligase; Region: PanC; cd00560 527021004423 active site 527021004424 ATP-binding site [chemical binding]; other site 527021004425 pantoate-binding site; other site 527021004426 HXXH motif; other site 527021004427 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 527021004428 tetramerization interface [polypeptide binding]; other site 527021004429 active site 527021004430 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 527021004431 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 527021004432 active site 527021004433 catalytic site [active] 527021004434 substrate binding site [chemical binding]; other site 527021004435 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 527021004436 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 527021004437 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 527021004438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 527021004439 aspartate aminotransferase; Provisional; Region: PRK05764 527021004440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021004441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021004442 homodimer interface [polypeptide binding]; other site 527021004443 catalytic residue [active] 527021004444 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 527021004445 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 527021004446 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 527021004447 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 527021004448 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 527021004449 minor groove reading motif; other site 527021004450 helix-hairpin-helix signature motif; other site 527021004451 substrate binding pocket [chemical binding]; other site 527021004452 active site 527021004453 Transglycosylase; Region: Transgly; pfam00912 527021004454 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 527021004455 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021004456 Fibronectin type III domain; Region: fn3; pfam00041 527021004457 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 527021004458 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 527021004459 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 527021004460 YppF-like protein; Region: YppF; pfam14178 527021004461 YppG-like protein; Region: YppG; pfam14179 527021004462 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 527021004463 hypothetical protein; Provisional; Region: PRK13660 527021004464 cell division protein GpsB; Provisional; Region: PRK14127 527021004465 DivIVA domain; Region: DivI1A_domain; TIGR03544 527021004466 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 527021004467 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 527021004468 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 527021004469 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 527021004470 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 527021004471 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 527021004472 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 527021004473 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 527021004474 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 527021004475 active site 527021004476 Zn binding site [ion binding]; other site 527021004477 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021004478 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021004479 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 527021004480 active site 527021004481 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021004482 active site 527021004483 xanthine permease; Region: pbuX; TIGR03173 527021004484 Predicted membrane protein [Function unknown]; Region: COG2311 527021004485 Protein of unknown function (DUF418); Region: DUF418; cl12135 527021004486 Protein of unknown function (DUF418); Region: DUF418; pfam04235 527021004487 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 527021004488 Dynamin family; Region: Dynamin_N; pfam00350 527021004489 G1 box; other site 527021004490 GTP/Mg2+ binding site [chemical binding]; other site 527021004491 G2 box; other site 527021004492 Switch I region; other site 527021004493 G3 box; other site 527021004494 Switch II region; other site 527021004495 G4 box; other site 527021004496 G5 box; other site 527021004497 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 527021004498 Dynamin family; Region: Dynamin_N; pfam00350 527021004499 G1 box; other site 527021004500 GTP/Mg2+ binding site [chemical binding]; other site 527021004501 G2 box; other site 527021004502 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 527021004503 G3 box; other site 527021004504 Switch II region; other site 527021004505 GTP/Mg2+ binding site [chemical binding]; other site 527021004506 G4 box; other site 527021004507 G5 box; other site 527021004508 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 527021004509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021004510 Coenzyme A binding pocket [chemical binding]; other site 527021004511 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 527021004512 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 527021004513 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 527021004514 active site residue [active] 527021004515 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 527021004516 active site residue [active] 527021004517 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 527021004518 Predicted membrane protein [Function unknown]; Region: COG3766 527021004519 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 527021004520 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 527021004521 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 527021004522 5'-3' exonuclease; Region: 53EXOc; smart00475 527021004523 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 527021004524 active site 527021004525 metal binding site 1 [ion binding]; metal-binding site 527021004526 putative 5' ssDNA interaction site; other site 527021004527 metal binding site 3; metal-binding site 527021004528 metal binding site 2 [ion binding]; metal-binding site 527021004529 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 527021004530 putative DNA binding site [nucleotide binding]; other site 527021004531 putative metal binding site [ion binding]; other site 527021004532 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 527021004533 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 527021004534 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 527021004535 Chain length determinant protein; Region: Wzz; cl15801 527021004536 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 527021004537 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 527021004538 Bacterial sugar transferase; Region: Bac_transf; pfam02397 527021004539 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 527021004540 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 527021004541 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 527021004542 O-Antigen ligase; Region: Wzy_C; pfam04932 527021004543 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 527021004544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 527021004545 active site 527021004546 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 527021004547 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 527021004548 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 527021004549 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004550 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004551 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004552 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004553 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004554 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004555 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004556 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004557 Domain of unknown function DUF11; Region: DUF11; cl17728 527021004558 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004559 Domain of unknown function DUF11; Region: DUF11; cl17728 527021004560 Domain of unknown function DUF11; Region: DUF11; cl17728 527021004561 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004562 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004563 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004564 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004565 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004566 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004567 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004568 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004569 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004570 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004571 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004572 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004573 Domain of unknown function DUF11; Region: DUF11; cl17728 527021004574 Domain of unknown function DUF11; Region: DUF11; cl17728 527021004575 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004576 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021004577 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 527021004578 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 527021004579 Isochorismatase family; Region: Isochorismatase; pfam00857 527021004580 catalytic triad [active] 527021004581 conserved cis-peptide bond; other site 527021004582 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021004583 EamA-like transporter family; Region: EamA; pfam00892 527021004584 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 527021004585 RNA/DNA hybrid binding site [nucleotide binding]; other site 527021004586 active site 527021004587 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 527021004588 active site 527021004589 catalytic residues [active] 527021004590 QueT transporter; Region: QueT; pfam06177 527021004591 hypothetical protein; Validated; Region: PRK07708 527021004592 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 527021004593 RNA/DNA hybrid binding site [nucleotide binding]; other site 527021004594 active site 527021004595 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 527021004596 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 527021004597 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 527021004598 DNA-binding site [nucleotide binding]; DNA binding site 527021004599 RNA-binding motif; other site 527021004600 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 527021004601 LysE type translocator; Region: LysE; pfam01810 527021004602 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 527021004603 Protein of unknown function, DUF485; Region: DUF485; pfam04341 527021004604 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 527021004605 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 527021004606 Na binding site [ion binding]; other site 527021004607 aminotransferase; Validated; Region: PRK07678 527021004608 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 527021004609 inhibitor-cofactor binding pocket; inhibition site 527021004610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021004611 catalytic residue [active] 527021004612 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 527021004613 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 527021004614 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 527021004615 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 527021004616 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 527021004617 DNA binding residues [nucleotide binding] 527021004618 drug binding residues [chemical binding]; other site 527021004619 dimer interface [polypeptide binding]; other site 527021004620 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 527021004621 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 527021004622 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 527021004623 Predicted membrane protein [Function unknown]; Region: COG2323 527021004624 Uncharacterized conserved protein [Function unknown]; Region: COG1434 527021004625 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 527021004626 putative active site [active] 527021004627 Tic20-like protein; Region: Tic20; pfam09685 527021004628 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 527021004629 dimer interface [polypeptide binding]; other site 527021004630 FMN binding site [chemical binding]; other site 527021004631 NADPH bind site [chemical binding]; other site 527021004632 RNA polymerase factor sigma-70; Validated; Region: PRK06811 527021004633 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021004634 DNA binding residues [nucleotide binding] 527021004635 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 527021004636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021004637 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021004638 putative substrate translocation pore; other site 527021004639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021004640 dimerization interface [polypeptide binding]; other site 527021004641 putative DNA binding site [nucleotide binding]; other site 527021004642 putative Zn2+ binding site [ion binding]; other site 527021004643 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021004644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021004645 putative substrate translocation pore; other site 527021004646 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 527021004647 active site 527021004648 metal binding site [ion binding]; metal-binding site 527021004649 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021004650 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 527021004651 bacterial Hfq-like; Region: Hfq; cd01716 527021004652 hexamer interface [polypeptide binding]; other site 527021004653 Sm1 motif; other site 527021004654 RNA binding site [nucleotide binding]; other site 527021004655 Sm2 motif; other site 527021004656 HD domain; Region: HD_3; pfam13023 527021004657 flagellar motor protein MotP; Reviewed; Region: PRK06743 527021004658 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 527021004659 flagellar motor protein MotS; Reviewed; Region: PRK06742 527021004660 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 527021004661 ligand binding site [chemical binding]; other site 527021004662 Response regulator receiver domain; Region: Response_reg; pfam00072 527021004663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021004664 active site 527021004665 phosphorylation site [posttranslational modification] 527021004666 intermolecular recognition site; other site 527021004667 dimerization interface [polypeptide binding]; other site 527021004668 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 527021004669 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 527021004670 putative binding surface; other site 527021004671 active site 527021004672 P2 response regulator binding domain; Region: P2; pfam07194 527021004673 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 527021004674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021004675 ATP binding site [chemical binding]; other site 527021004676 Mg2+ binding site [ion binding]; other site 527021004677 G-X-G motif; other site 527021004678 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 527021004679 flagellar motor switch protein; Reviewed; Region: PRK06782 527021004680 CheC-like family; Region: CheC; pfam04509 527021004681 CheC-like family; Region: CheC; pfam04509 527021004682 CheC-like family; Region: CheC; pfam04509 527021004683 CheC-like family; Region: CheC; pfam04509 527021004684 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 527021004685 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 527021004686 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 527021004687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021004688 Protein of unknown function (DUF327); Region: DUF327; pfam03885 527021004689 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 527021004690 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 527021004691 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 527021004692 flagellar capping protein; Validated; Region: fliD; PRK06798 527021004693 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 527021004694 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 527021004695 Flagellar protein FliS; Region: FliS; cl00654 527021004696 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 527021004697 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 527021004698 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 527021004699 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 527021004700 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 527021004701 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 527021004702 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 527021004703 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 527021004704 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 527021004705 FliG C-terminal domain; Region: FliG_C; pfam01706 527021004706 flagellar assembly protein H; Validated; Region: fliH; PRK06800 527021004707 Flagellar assembly protein FliH; Region: FliH; pfam02108 527021004708 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 527021004709 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 527021004710 Walker A motif; other site 527021004711 ATP binding site [chemical binding]; other site 527021004712 Walker B motif; other site 527021004713 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 527021004714 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 527021004715 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 527021004716 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 527021004717 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 527021004718 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 527021004719 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 527021004720 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 527021004721 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 527021004722 Response regulator receiver domain; Region: Response_reg; pfam00072 527021004723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021004724 active site 527021004725 phosphorylation site [posttranslational modification] 527021004726 intermolecular recognition site; other site 527021004727 dimerization interface [polypeptide binding]; other site 527021004728 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 527021004729 flagellin; Provisional; Region: PRK12807 527021004730 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 527021004731 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 527021004732 flagellin; Reviewed; Region: PRK08869 527021004733 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 527021004734 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 527021004735 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 527021004736 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 527021004737 N-acetyl-D-glucosamine binding site [chemical binding]; other site 527021004738 catalytic residue [active] 527021004739 flagellar motor switch protein; Validated; Region: PRK06789 527021004740 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 527021004741 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 527021004742 flagellar motor switch protein; Validated; Region: PRK06788 527021004743 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 527021004744 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 527021004745 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 527021004746 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 527021004747 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 527021004748 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 527021004749 FHIPEP family; Region: FHIPEP; pfam00771 527021004750 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 527021004751 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 527021004752 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 527021004753 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 527021004754 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 527021004755 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 527021004756 active site 527021004757 non-prolyl cis peptide bond; other site 527021004758 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 527021004759 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 527021004760 Predicted transcriptional regulators [Transcription]; Region: COG1378 527021004761 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 527021004762 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 527021004763 C-terminal domain interface [polypeptide binding]; other site 527021004764 sugar binding site [chemical binding]; other site 527021004765 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 527021004766 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 527021004767 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 527021004768 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 527021004769 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 527021004770 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 527021004771 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 527021004772 DXD motif; other site 527021004773 PilZ domain; Region: PilZ; pfam07238 527021004774 PilZ domain; Region: PilZ; pfam07238 527021004775 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 527021004776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021004777 non-specific DNA binding site [nucleotide binding]; other site 527021004778 salt bridge; other site 527021004779 sequence-specific DNA binding site [nucleotide binding]; other site 527021004780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021004781 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021004782 putative substrate translocation pore; other site 527021004783 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 527021004784 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 527021004785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021004786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 527021004787 dimerization interface [polypeptide binding]; other site 527021004788 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 527021004789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021004790 Walker A/P-loop; other site 527021004791 ATP binding site [chemical binding]; other site 527021004792 Q-loop/lid; other site 527021004793 ABC transporter signature motif; other site 527021004794 Walker B; other site 527021004795 D-loop; other site 527021004796 H-loop/switch region; other site 527021004797 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 527021004798 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 527021004799 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 527021004800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021004801 dimer interface [polypeptide binding]; other site 527021004802 conserved gate region; other site 527021004803 putative PBP binding loops; other site 527021004804 ABC-ATPase subunit interface; other site 527021004805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021004806 dimer interface [polypeptide binding]; other site 527021004807 conserved gate region; other site 527021004808 putative PBP binding loops; other site 527021004809 ABC-ATPase subunit interface; other site 527021004810 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 527021004811 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 527021004812 Beta-Casp domain; Region: Beta-Casp; smart01027 527021004813 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 527021004814 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021004815 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021004816 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 527021004817 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 527021004818 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 527021004819 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 527021004820 catalytic core [active] 527021004821 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 527021004822 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021004823 hypothetical protein; Provisional; Region: PRK09272 527021004824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021004825 dimerization interface [polypeptide binding]; other site 527021004826 putative Zn2+ binding site [ion binding]; other site 527021004827 putative DNA binding site [nucleotide binding]; other site 527021004828 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 527021004829 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 527021004830 active site 527021004831 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 527021004832 dimer interface [polypeptide binding]; other site 527021004833 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 527021004834 Ligand Binding Site [chemical binding]; other site 527021004835 Molecular Tunnel; other site 527021004836 RNA polymerase factor sigma-70; Validated; Region: PRK06811 527021004837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021004838 DNA binding residues [nucleotide binding] 527021004839 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 527021004840 VPS10 domain; Region: VPS10; smart00602 527021004841 VPS10 domain; Region: VPS10; smart00602 527021004842 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 527021004843 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 527021004844 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 527021004845 Transcriptional regulators [Transcription]; Region: GntR; COG1802 527021004846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021004847 DNA-binding site [nucleotide binding]; DNA binding site 527021004848 FCD domain; Region: FCD; pfam07729 527021004849 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021004850 EamA-like transporter family; Region: EamA; pfam00892 527021004851 EamA-like transporter family; Region: EamA; pfam00892 527021004852 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 527021004853 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 527021004854 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 527021004855 Predicted permeases [General function prediction only]; Region: COG0701 527021004856 TIGR03943 family protein; Region: TIGR03943 527021004857 Methyltransferase domain; Region: Methyltransf_24; pfam13578 527021004858 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 527021004859 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 527021004860 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 527021004861 DNA binding residues [nucleotide binding] 527021004862 putative dimer interface [polypeptide binding]; other site 527021004863 short chain dehydrogenase; Provisional; Region: PRK06123 527021004864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021004865 NAD(P) binding site [chemical binding]; other site 527021004866 active site 527021004867 fumarate hydratase; Reviewed; Region: fumC; PRK00485 527021004868 Class II fumarases; Region: Fumarase_classII; cd01362 527021004869 active site 527021004870 tetramer interface [polypeptide binding]; other site 527021004871 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 527021004872 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 527021004873 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 527021004874 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 527021004875 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 527021004876 active site pocket [active] 527021004877 oxyanion hole [active] 527021004878 catalytic triad [active] 527021004879 active site nucleophile [active] 527021004880 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 527021004881 Penicillinase repressor; Region: Pencillinase_R; pfam03965 527021004882 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 527021004883 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 527021004884 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 527021004885 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 527021004886 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 527021004887 catalytic residues [active] 527021004888 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 527021004889 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021004890 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 527021004891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021004892 non-specific DNA binding site [nucleotide binding]; other site 527021004893 salt bridge; other site 527021004894 sequence-specific DNA binding site [nucleotide binding]; other site 527021004895 Cupin domain; Region: Cupin_2; pfam07883 527021004896 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 527021004897 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 527021004898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021004899 catalytic residue [active] 527021004900 Protein of unknown function (DUF445); Region: DUF445; pfam04286 527021004901 Pleckstrin homology-like domain; Region: PH-like; cl17171 527021004902 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 527021004903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021004904 DNA binding residues [nucleotide binding] 527021004905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021004906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021004907 active site 527021004908 phosphorylation site [posttranslational modification] 527021004909 intermolecular recognition site; other site 527021004910 dimerization interface [polypeptide binding]; other site 527021004911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021004912 DNA binding residues [nucleotide binding] 527021004913 dimerization interface [polypeptide binding]; other site 527021004914 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021004915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021004916 Walker A/P-loop; other site 527021004917 ATP binding site [chemical binding]; other site 527021004918 Q-loop/lid; other site 527021004919 ABC transporter signature motif; other site 527021004920 Walker B; other site 527021004921 D-loop; other site 527021004922 H-loop/switch region; other site 527021004923 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 527021004924 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 527021004925 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 527021004926 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 527021004927 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 527021004928 putative active site [active] 527021004929 catalytic site [active] 527021004930 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 527021004931 PLD-like domain; Region: PLDc_2; pfam13091 527021004932 putative active site [active] 527021004933 catalytic site [active] 527021004934 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 527021004935 putative nucleotide binding site [chemical binding]; other site 527021004936 uridine monophosphate binding site [chemical binding]; other site 527021004937 homohexameric interface [polypeptide binding]; other site 527021004938 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 527021004939 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 527021004940 aspartate ammonia-lyase; Provisional; Region: PRK14515 527021004941 Aspartase; Region: Aspartase; cd01357 527021004942 active sites [active] 527021004943 tetramer interface [polypeptide binding]; other site 527021004944 malate dehydrogenase; Provisional; Region: PRK13529 527021004945 Malic enzyme, N-terminal domain; Region: malic; pfam00390 527021004946 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 527021004947 NAD(P) binding site [chemical binding]; other site 527021004948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021004949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021004950 ATP binding site [chemical binding]; other site 527021004951 Mg2+ binding site [ion binding]; other site 527021004952 G-X-G motif; other site 527021004953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021004954 Response regulator receiver domain; Region: Response_reg; pfam00072 527021004955 active site 527021004956 phosphorylation site [posttranslational modification] 527021004957 intermolecular recognition site; other site 527021004958 dimerization interface [polypeptide binding]; other site 527021004959 YcbB domain; Region: YcbB; pfam08664 527021004960 SWIM zinc finger; Region: SWIM; pfam04434 527021004961 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 527021004962 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 527021004963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021004964 ATP binding site [chemical binding]; other site 527021004965 putative Mg++ binding site [ion binding]; other site 527021004966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021004967 nucleotide binding region [chemical binding]; other site 527021004968 ATP-binding site [chemical binding]; other site 527021004969 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 527021004970 dimer interface [polypeptide binding]; other site 527021004971 active site 527021004972 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021004973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021004974 non-specific DNA binding site [nucleotide binding]; other site 527021004975 salt bridge; other site 527021004976 sequence-specific DNA binding site [nucleotide binding]; other site 527021004977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 527021004978 putative dimer interface [polypeptide binding]; other site 527021004979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021004980 aspartate kinase; Reviewed; Region: PRK06635 527021004981 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 527021004982 putative nucleotide binding site [chemical binding]; other site 527021004983 putative catalytic residues [active] 527021004984 putative Mg ion binding site [ion binding]; other site 527021004985 putative aspartate binding site [chemical binding]; other site 527021004986 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 527021004987 putative allosteric regulatory site; other site 527021004988 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 527021004989 putative allosteric regulatory residue; other site 527021004990 DoxX-like family; Region: DoxX_3; pfam13781 527021004991 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 527021004992 YndJ-like protein; Region: YndJ; pfam14158 527021004993 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 527021004994 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021004995 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 527021004996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021004997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021004998 putative substrate translocation pore; other site 527021004999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021005000 putative substrate translocation pore; other site 527021005001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021005002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021005003 putative substrate translocation pore; other site 527021005004 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 527021005005 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 527021005006 dimer interface [polypeptide binding]; other site 527021005007 active site 527021005008 CoA binding pocket [chemical binding]; other site 527021005009 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 527021005010 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 527021005011 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 527021005012 HflX GTPase family; Region: HflX; cd01878 527021005013 G1 box; other site 527021005014 GTP/Mg2+ binding site [chemical binding]; other site 527021005015 Switch I region; other site 527021005016 G2 box; other site 527021005017 G3 box; other site 527021005018 Switch II region; other site 527021005019 G4 box; other site 527021005020 G5 box; other site 527021005021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021005022 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021005023 putative substrate translocation pore; other site 527021005024 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 527021005025 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 527021005026 dimer interface [polypeptide binding]; other site 527021005027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021005028 catalytic residue [active] 527021005029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021005030 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 527021005031 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 527021005032 Na2 binding site [ion binding]; other site 527021005033 putative substrate binding site 1 [chemical binding]; other site 527021005034 Na binding site 1 [ion binding]; other site 527021005035 putative substrate binding site 2 [chemical binding]; other site 527021005036 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 527021005037 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 527021005038 NodB motif; other site 527021005039 putative active site [active] 527021005040 putative catalytic site [active] 527021005041 putative Zn binding site [ion binding]; other site 527021005042 Mor transcription activator family; Region: Mor; cl02360 527021005043 Predicted membrane protein [Function unknown]; Region: COG2323 527021005044 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 527021005045 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 527021005046 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 527021005047 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 527021005048 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 527021005049 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 527021005050 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 527021005051 methionine sulfoxide reductase A; Provisional; Region: PRK14054 527021005052 short chain dehydrogenase; Provisional; Region: PRK12747 527021005053 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 527021005054 NADP binding site [chemical binding]; other site 527021005055 homodimer interface [polypeptide binding]; other site 527021005056 active site 527021005057 substrate binding site [chemical binding]; other site 527021005058 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 527021005059 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 527021005060 homodimer interface [polypeptide binding]; other site 527021005061 substrate-cofactor binding pocket; other site 527021005062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021005063 catalytic residue [active] 527021005064 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 527021005065 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 527021005066 PYR/PP interface [polypeptide binding]; other site 527021005067 dimer interface [polypeptide binding]; other site 527021005068 TPP binding site [chemical binding]; other site 527021005069 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 527021005070 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 527021005071 TPP-binding site [chemical binding]; other site 527021005072 dimer interface [polypeptide binding]; other site 527021005073 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 527021005074 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 527021005075 putative valine binding site [chemical binding]; other site 527021005076 dimer interface [polypeptide binding]; other site 527021005077 ketol-acid reductoisomerase; Provisional; Region: PRK05479 527021005078 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 527021005079 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 527021005080 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 527021005081 threonine dehydratase; Validated; Region: PRK08639 527021005082 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 527021005083 tetramer interface [polypeptide binding]; other site 527021005084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021005085 catalytic residue [active] 527021005086 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 527021005087 putative Ile/Val binding site [chemical binding]; other site 527021005088 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 527021005089 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 527021005090 putative active site [active] 527021005091 putative metal binding site [ion binding]; other site 527021005092 Protein of unknown function (DUF554); Region: DUF554; pfam04474 527021005093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005094 Coenzyme A binding pocket [chemical binding]; other site 527021005095 drug efflux system protein MdtG; Provisional; Region: PRK09874 527021005096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021005097 putative substrate translocation pore; other site 527021005098 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 527021005099 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 527021005100 putative active site [active] 527021005101 metal binding site [ion binding]; metal-binding site 527021005102 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 527021005103 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 527021005104 LytTr DNA-binding domain; Region: LytTR; pfam04397 527021005105 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 527021005106 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 527021005107 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 527021005108 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 527021005109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021005110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005111 Coenzyme A binding pocket [chemical binding]; other site 527021005112 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 527021005113 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 527021005114 active site 527021005115 putative substrate binding pocket [chemical binding]; other site 527021005116 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 527021005117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021005118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021005119 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021005120 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021005121 peptide binding site [polypeptide binding]; other site 527021005122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021005123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005124 Coenzyme A binding pocket [chemical binding]; other site 527021005125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021005126 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021005127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021005128 active site 527021005129 phosphorylation site [posttranslational modification] 527021005130 intermolecular recognition site; other site 527021005131 dimerization interface [polypeptide binding]; other site 527021005132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021005133 DNA binding site [nucleotide binding] 527021005134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021005135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021005136 dimerization interface [polypeptide binding]; other site 527021005137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021005138 dimer interface [polypeptide binding]; other site 527021005139 phosphorylation site [posttranslational modification] 527021005140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021005141 ATP binding site [chemical binding]; other site 527021005142 Mg2+ binding site [ion binding]; other site 527021005143 G-X-G motif; other site 527021005144 Peptidase family M23; Region: Peptidase_M23; pfam01551 527021005145 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 527021005146 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021005147 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 527021005148 manganese transport protein MntH; Reviewed; Region: PRK00701 527021005149 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 527021005150 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 527021005151 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 527021005152 active site residue [active] 527021005153 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 527021005154 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 527021005155 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 527021005156 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 527021005157 Amino acid permease; Region: AA_permease_2; pfam13520 527021005158 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 527021005159 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 527021005160 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 527021005161 Peptidase M60-like family; Region: M60-like; pfam13402 527021005162 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 527021005163 sugar binding site [chemical binding]; other site 527021005164 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 527021005165 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 527021005166 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021005167 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 527021005168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021005169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021005170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005171 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021005172 Coenzyme A binding pocket [chemical binding]; other site 527021005173 hypothetical protein; Provisional; Region: PRK12856 527021005174 CAAX protease self-immunity; Region: Abi; pfam02517 527021005175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021005176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021005177 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 527021005178 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021005179 DNA binding residues [nucleotide binding] 527021005180 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 527021005181 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 527021005182 intersubunit interface [polypeptide binding]; other site 527021005183 active site 527021005184 catalytic residue [active] 527021005185 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 527021005186 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 527021005187 Nucleoside recognition; Region: Gate; pfam07670 527021005188 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 527021005189 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 527021005190 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 527021005191 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 527021005192 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 527021005193 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 527021005194 active site 527021005195 catalytic motif [active] 527021005196 Zn binding site [ion binding]; other site 527021005197 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 527021005198 hypothetical protein; Provisional; Region: PRK01631 527021005199 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 527021005200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021005201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021005202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021005203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 527021005204 dimerization interface [polypeptide binding]; other site 527021005205 Family description; Region: DsbD_2; pfam13386 527021005206 VPS10 domain; Region: VPS10; smart00602 527021005207 proline aminopeptidase P II; Provisional; Region: PRK10879 527021005208 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 527021005209 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 527021005210 active site 527021005211 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 527021005212 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 527021005213 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 527021005214 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 527021005215 Multicopper oxidase; Region: Cu-oxidase; pfam00394 527021005216 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 527021005217 DNA topoisomerase III; Provisional; Region: PRK07726 527021005218 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 527021005219 active site 527021005220 putative interdomain interaction site [polypeptide binding]; other site 527021005221 putative metal-binding site [ion binding]; other site 527021005222 putative nucleotide binding site [chemical binding]; other site 527021005223 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 527021005224 domain I; other site 527021005225 DNA binding groove [nucleotide binding] 527021005226 phosphate binding site [ion binding]; other site 527021005227 domain II; other site 527021005228 domain III; other site 527021005229 nucleotide binding site [chemical binding]; other site 527021005230 catalytic site [active] 527021005231 domain IV; other site 527021005232 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 527021005233 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 527021005234 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 527021005235 Sodium Bile acid symporter family; Region: SBF; cl17470 527021005236 azoreductase; Provisional; Region: PRK13555 527021005237 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 527021005238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021005239 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 527021005240 dimer interface [polypeptide binding]; other site 527021005241 substrate binding site [chemical binding]; other site 527021005242 metal binding site [ion binding]; metal-binding site 527021005243 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 527021005244 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 527021005245 YtkA-like; Region: YtkA; pfam13115 527021005246 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 527021005247 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 527021005248 EamA-like transporter family; Region: EamA; pfam00892 527021005249 EamA-like transporter family; Region: EamA; pfam00892 527021005250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021005251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021005252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 527021005253 dimerization interface [polypeptide binding]; other site 527021005254 Predicted transcriptional regulator [Transcription]; Region: COG1959 527021005255 Transcriptional regulator; Region: Rrf2; pfam02082 527021005256 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 527021005257 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 527021005258 catalytic residues [active] 527021005259 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 527021005260 dimer interface [polypeptide binding]; other site 527021005261 FMN binding site [chemical binding]; other site 527021005262 Amidase; Region: Amidase; cl11426 527021005263 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021005264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021005265 non-specific DNA binding site [nucleotide binding]; other site 527021005266 salt bridge; other site 527021005267 sequence-specific DNA binding site [nucleotide binding]; other site 527021005268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021005269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021005270 non-specific DNA binding site [nucleotide binding]; other site 527021005271 salt bridge; other site 527021005272 sequence-specific DNA binding site [nucleotide binding]; other site 527021005273 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021005274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021005275 non-specific DNA binding site [nucleotide binding]; other site 527021005276 salt bridge; other site 527021005277 sequence-specific DNA binding site [nucleotide binding]; other site 527021005278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021005279 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021005280 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021005281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021005282 AAA domain; Region: AAA_23; pfam13476 527021005283 Walker A/P-loop; other site 527021005284 ATP binding site [chemical binding]; other site 527021005285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021005286 Walker B; other site 527021005287 D-loop; other site 527021005288 H-loop/switch region; other site 527021005289 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 527021005290 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021005291 active site 527021005292 metal binding site [ion binding]; metal-binding site 527021005293 DNA binding site [nucleotide binding] 527021005294 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 527021005295 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021005296 ATP binding site [chemical binding]; other site 527021005297 putative Mg++ binding site [ion binding]; other site 527021005298 helicase superfamily c-terminal domain; Region: HELICc; smart00490 527021005299 ATP-binding site [chemical binding]; other site 527021005300 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 527021005301 nucleotide binding site [chemical binding]; other site 527021005302 Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; Region: MCM2; COG1241 527021005303 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 527021005304 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 527021005305 active site 527021005306 substrate binding site [chemical binding]; other site 527021005307 catalytic site [active] 527021005308 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 527021005309 active site 527021005310 DNA binding site [nucleotide binding] 527021005311 catalytic site [active] 527021005312 dUTPase; Region: dUTPase_2; pfam08761 527021005313 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 527021005314 active site 527021005315 homodimer interface [polypeptide binding]; other site 527021005316 metal binding site [ion binding]; metal-binding site 527021005317 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; Region: SANT; cl15779 527021005318 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 527021005319 DNA methylase; Region: N6_N4_Mtase; pfam01555 527021005320 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564 527021005321 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 527021005322 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 527021005323 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 527021005324 catalytic residues [active] 527021005325 catalytic nucleophile [active] 527021005326 Presynaptic Site I dimer interface [polypeptide binding]; other site 527021005327 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 527021005328 Synaptic Flat tetramer interface [polypeptide binding]; other site 527021005329 Synaptic Site I dimer interface [polypeptide binding]; other site 527021005330 DNA binding site [nucleotide binding] 527021005331 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 527021005332 DNA-binding interface [nucleotide binding]; DNA binding site 527021005333 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 527021005334 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 527021005335 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 527021005336 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 527021005337 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 527021005338 Head fiber protein; Region: Phage_head_fibr; pfam11133 527021005339 phage major tail protein, TP901-1 family; Region: phgtail_TP901_1; TIGR02126 527021005340 Phage protein; Region: DUF3647; pfam12363 527021005341 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 527021005342 Phage-related protein [Function unknown]; Region: COG5412 527021005343 Phage tail protein; Region: Sipho_tail; pfam05709 527021005344 Phage tail protein; Region: Sipho_tail; cl17486 527021005345 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 527021005346 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 527021005347 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 527021005348 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 527021005349 active site 527021005350 catalytic residues [active] 527021005351 DNA binding site [nucleotide binding] 527021005352 Int/Topo IB signature motif; other site 527021005353 Holin family; Region: Phage_holin_4; pfam05105 527021005354 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 527021005355 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 527021005356 active site 527021005357 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 527021005358 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 527021005359 non-specific DNA binding site [nucleotide binding]; other site 527021005360 sequence-specific DNA binding site [nucleotide binding]; other site 527021005361 salt bridge; other site 527021005362 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 527021005363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021005364 non-specific DNA binding site [nucleotide binding]; other site 527021005365 salt bridge; other site 527021005366 sequence-specific DNA binding site [nucleotide binding]; other site 527021005367 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 527021005368 Replication-relaxation; Region: Replic_Relax; pfam13814 527021005369 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 527021005370 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 527021005371 catalytic residues [active] 527021005372 catalytic nucleophile [active] 527021005373 Recombinase; Region: Recombinase; pfam07508 527021005374 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 527021005375 Recombinase; Region: Recombinase; pfam07508 527021005376 Amidase; Region: Amidase; cl11426 527021005377 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 527021005378 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 527021005379 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 527021005380 tetramer (dimer of dimers) interface [polypeptide binding]; other site 527021005381 NAD binding site [chemical binding]; other site 527021005382 dimer interface [polypeptide binding]; other site 527021005383 substrate binding site [chemical binding]; other site 527021005384 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 527021005385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 527021005386 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 527021005387 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 527021005388 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 527021005389 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 527021005390 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 527021005391 putative ligand binding site [chemical binding]; other site 527021005392 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 527021005393 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 527021005394 Walker A/P-loop; other site 527021005395 ATP binding site [chemical binding]; other site 527021005396 Q-loop/lid; other site 527021005397 ABC transporter signature motif; other site 527021005398 Walker B; other site 527021005399 D-loop; other site 527021005400 H-loop/switch region; other site 527021005401 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 527021005402 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 527021005403 Walker A/P-loop; other site 527021005404 ATP binding site [chemical binding]; other site 527021005405 Q-loop/lid; other site 527021005406 ABC transporter signature motif; other site 527021005407 Walker B; other site 527021005408 D-loop; other site 527021005409 H-loop/switch region; other site 527021005410 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 527021005411 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 527021005412 TM-ABC transporter signature motif; other site 527021005413 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 527021005414 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 527021005415 TM-ABC transporter signature motif; other site 527021005416 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021005417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021005418 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 527021005419 dimerization interface [polypeptide binding]; other site 527021005420 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 527021005421 active site 1 [active] 527021005422 dimer interface [polypeptide binding]; other site 527021005423 hexamer interface [polypeptide binding]; other site 527021005424 active site 2 [active] 527021005425 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 527021005426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021005427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021005428 putative Zn2+ binding site [ion binding]; other site 527021005429 putative DNA binding site [nucleotide binding]; other site 527021005430 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 527021005431 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 527021005432 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 527021005433 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 527021005434 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 527021005435 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 527021005436 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 527021005437 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021005438 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 527021005439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021005440 Walker A/P-loop; other site 527021005441 ATP binding site [chemical binding]; other site 527021005442 Q-loop/lid; other site 527021005443 ABC transporter signature motif; other site 527021005444 Walker B; other site 527021005445 D-loop; other site 527021005446 H-loop/switch region; other site 527021005447 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 527021005448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021005449 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 527021005450 Walker A/P-loop; other site 527021005451 ATP binding site [chemical binding]; other site 527021005452 Q-loop/lid; other site 527021005453 ABC transporter signature motif; other site 527021005454 Walker B; other site 527021005455 D-loop; other site 527021005456 H-loop/switch region; other site 527021005457 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 527021005458 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 527021005459 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 527021005460 active site 527021005461 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 527021005462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 527021005463 active site 527021005464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021005465 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021005466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 527021005467 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 527021005468 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 527021005469 inhibitor-cofactor binding pocket; inhibition site 527021005470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021005471 catalytic residue [active] 527021005472 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 527021005473 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 527021005474 trimer interface [polypeptide binding]; other site 527021005475 active site 527021005476 substrate binding site [chemical binding]; other site 527021005477 CoA binding site [chemical binding]; other site 527021005478 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 527021005479 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 527021005480 putative dimer interface [polypeptide binding]; other site 527021005481 catalytic triad [active] 527021005482 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021005483 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 527021005484 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 527021005485 dimer interface [polypeptide binding]; other site 527021005486 FMN binding site [chemical binding]; other site 527021005487 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021005488 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021005489 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021005490 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 527021005491 NlpC/P60 family; Region: NLPC_P60; pfam00877 527021005492 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 527021005493 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 527021005494 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021005495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021005496 Walker A/P-loop; other site 527021005497 ATP binding site [chemical binding]; other site 527021005498 Q-loop/lid; other site 527021005499 ABC transporter signature motif; other site 527021005500 Walker B; other site 527021005501 D-loop; other site 527021005502 H-loop/switch region; other site 527021005503 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021005504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021005505 active site 527021005506 phosphorylation site [posttranslational modification] 527021005507 intermolecular recognition site; other site 527021005508 dimerization interface [polypeptide binding]; other site 527021005509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021005510 DNA binding site [nucleotide binding] 527021005511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021005512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021005513 dimerization interface [polypeptide binding]; other site 527021005514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021005515 dimer interface [polypeptide binding]; other site 527021005516 phosphorylation site [posttranslational modification] 527021005517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021005518 ATP binding site [chemical binding]; other site 527021005519 Mg2+ binding site [ion binding]; other site 527021005520 G-X-G motif; other site 527021005521 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 527021005522 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 527021005523 classical (c) SDRs; Region: SDR_c; cd05233 527021005524 NAD(P) binding site [chemical binding]; other site 527021005525 active site 527021005526 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 527021005527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021005528 S-adenosylmethionine binding site [chemical binding]; other site 527021005529 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 527021005530 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 527021005531 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 527021005532 NodB motif; other site 527021005533 active site 527021005534 catalytic site [active] 527021005535 metal binding site [ion binding]; metal-binding site 527021005536 SdpI/YhfL protein family; Region: SdpI; pfam13630 527021005537 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 527021005538 nudix motif; other site 527021005539 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 527021005540 homoserine dehydrogenase; Provisional; Region: PRK06349 527021005541 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 527021005542 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 527021005543 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 527021005544 threonine synthase; Reviewed; Region: PRK06721 527021005545 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 527021005546 homodimer interface [polypeptide binding]; other site 527021005547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021005548 catalytic residue [active] 527021005549 homoserine kinase; Provisional; Region: PRK01212 527021005550 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 527021005551 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 527021005552 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 527021005553 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 527021005554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021005555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021005556 active site 527021005557 phosphorylation site [posttranslational modification] 527021005558 intermolecular recognition site; other site 527021005559 dimerization interface [polypeptide binding]; other site 527021005560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021005561 DNA binding site [nucleotide binding] 527021005562 HAMP domain; Region: HAMP; pfam00672 527021005563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021005564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021005565 dimer interface [polypeptide binding]; other site 527021005566 phosphorylation site [posttranslational modification] 527021005567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021005568 ATP binding site [chemical binding]; other site 527021005569 Mg2+ binding site [ion binding]; other site 527021005570 G-X-G motif; other site 527021005571 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 527021005572 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 527021005573 NodB motif; other site 527021005574 active site 527021005575 catalytic site [active] 527021005576 Zn binding site [ion binding]; other site 527021005577 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 527021005578 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 527021005579 MgtC family; Region: MgtC; pfam02308 527021005580 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 527021005581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005582 Coenzyme A binding pocket [chemical binding]; other site 527021005583 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 527021005584 IucA / IucC family; Region: IucA_IucC; pfam04183 527021005585 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 527021005586 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 527021005587 IucA / IucC family; Region: IucA_IucC; pfam04183 527021005588 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 527021005589 acyl-CoA synthetase; Validated; Region: PRK08308 527021005590 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 527021005591 acyl-activating enzyme (AAE) consensus motif; other site 527021005592 AMP binding site [chemical binding]; other site 527021005593 active site 527021005594 CoA binding site [chemical binding]; other site 527021005595 acyl carrier protein; Provisional; Region: PRK07639 527021005596 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 527021005597 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 527021005598 Metal-binding active site; metal-binding site 527021005599 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 527021005600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021005601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021005602 putative substrate translocation pore; other site 527021005603 Lysine efflux permease [General function prediction only]; Region: COG1279 527021005604 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021005605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021005606 DNA-binding site [nucleotide binding]; DNA binding site 527021005607 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021005608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021005609 homodimer interface [polypeptide binding]; other site 527021005610 catalytic residue [active] 527021005611 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 527021005612 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 527021005613 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 527021005614 active site 527021005615 nucleophile elbow; other site 527021005616 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 527021005617 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 527021005618 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 527021005619 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 527021005620 nudix motif; other site 527021005621 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 527021005622 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 527021005623 homodimer interface [polypeptide binding]; other site 527021005624 NAD binding pocket [chemical binding]; other site 527021005625 ATP binding pocket [chemical binding]; other site 527021005626 Mg binding site [ion binding]; other site 527021005627 active-site loop [active] 527021005628 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 527021005629 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 527021005630 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 527021005631 active site 527021005632 catalytic residues [active] 527021005633 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021005634 dimerization interface [polypeptide binding]; other site 527021005635 putative DNA binding site [nucleotide binding]; other site 527021005636 putative Zn2+ binding site [ion binding]; other site 527021005637 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 527021005638 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 527021005639 active site 527021005640 catalytic tetrad [active] 527021005641 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 527021005642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021005643 putative substrate translocation pore; other site 527021005644 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 527021005645 Protein of unknown function (DUF664); Region: DUF664; pfam04978 527021005646 DinB superfamily; Region: DinB_2; pfam12867 527021005647 GTPase RsgA; Reviewed; Region: PRK01889 527021005648 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 527021005649 RNA binding site [nucleotide binding]; other site 527021005650 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 527021005651 GTPase/Zn-binding domain interface [polypeptide binding]; other site 527021005652 GTP/Mg2+ binding site [chemical binding]; other site 527021005653 G4 box; other site 527021005654 G5 box; other site 527021005655 G1 box; other site 527021005656 Switch I region; other site 527021005657 G2 box; other site 527021005658 G3 box; other site 527021005659 Switch II region; other site 527021005660 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 527021005661 Cache domain; Region: Cache_1; pfam02743 527021005662 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021005663 dimerization interface [polypeptide binding]; other site 527021005664 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021005665 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021005666 dimer interface [polypeptide binding]; other site 527021005667 putative CheW interface [polypeptide binding]; other site 527021005668 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 527021005669 Uncharacterized membrane protein [Function unknown]; Region: COG3949 527021005670 Ferritin-like domain; Region: Ferritin; pfam00210 527021005671 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 527021005672 dimerization interface [polypeptide binding]; other site 527021005673 DPS ferroxidase diiron center [ion binding]; other site 527021005674 ion pore; other site 527021005675 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 527021005676 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 527021005677 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 527021005678 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 527021005679 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 527021005680 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 527021005681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 527021005682 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021005683 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021005684 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 527021005685 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 527021005686 active site 527021005687 catalytic tetrad [active] 527021005688 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 527021005689 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 527021005690 P-loop, Walker A motif; other site 527021005691 Base recognition motif; other site 527021005692 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 527021005693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021005694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005695 Coenzyme A binding pocket [chemical binding]; other site 527021005696 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 527021005697 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 527021005698 metal binding site [ion binding]; metal-binding site 527021005699 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 527021005700 NADH(P)-binding; Region: NAD_binding_10; pfam13460 527021005701 NAD binding site [chemical binding]; other site 527021005702 active site 527021005703 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 527021005704 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 527021005705 active site 527021005706 FMN binding site [chemical binding]; other site 527021005707 substrate binding site [chemical binding]; other site 527021005708 homotetramer interface [polypeptide binding]; other site 527021005709 catalytic residue [active] 527021005710 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 527021005711 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 527021005712 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021005713 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021005714 peptide binding site [polypeptide binding]; other site 527021005715 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 527021005716 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 527021005717 active site 527021005718 metal binding site [ion binding]; metal-binding site 527021005719 short chain dehydrogenase; Provisional; Region: PRK08309 527021005720 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 527021005721 catalytic core [active] 527021005722 CotH protein; Region: CotH; pfam08757 527021005723 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 527021005724 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 527021005725 nudix motif; other site 527021005726 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 527021005727 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 527021005728 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 527021005729 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 527021005730 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 527021005731 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 527021005732 Cl binding site [ion binding]; other site 527021005733 oligomer interface [polypeptide binding]; other site 527021005734 Predicted permeases [General function prediction only]; Region: COG0701 527021005735 Predicted membrane protein [Function unknown]; Region: COG3689 527021005736 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 527021005737 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 527021005738 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 527021005739 putative active site [active] 527021005740 catalytic site [active] 527021005741 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 527021005742 putative active site [active] 527021005743 catalytic site [active] 527021005744 Coat F domain; Region: Coat_F; pfam07875 527021005745 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 527021005746 NADH(P)-binding; Region: NAD_binding_10; pfam13460 527021005747 NAD binding site [chemical binding]; other site 527021005748 substrate binding site [chemical binding]; other site 527021005749 putative active site [active] 527021005750 Protein of unknown function (DUF456); Region: DUF456; pfam04306 527021005751 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 527021005752 Domain of unknown function DUF21; Region: DUF21; pfam01595 527021005753 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 527021005754 Transporter associated domain; Region: CorC_HlyC; smart01091 527021005755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021005756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021005757 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 527021005758 FOG: CBS domain [General function prediction only]; Region: COG0517 527021005759 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 527021005760 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 527021005761 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 527021005762 dimer interface [polypeptide binding]; other site 527021005763 putative tRNA-binding site [nucleotide binding]; other site 527021005764 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 527021005765 DinB superfamily; Region: DinB_2; pfam12867 527021005766 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 527021005767 stage II sporulation protein P; Region: spore_II_P; TIGR02867 527021005768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021005769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005770 Coenzyme A binding pocket [chemical binding]; other site 527021005771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021005772 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 527021005773 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 527021005774 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 527021005775 nudix motif; other site 527021005776 amidase; Provisional; Region: PRK06828 527021005777 Amidase; Region: Amidase; pfam01425 527021005778 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021005779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021005780 putative substrate translocation pore; other site 527021005781 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 527021005782 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 527021005783 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 527021005784 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 527021005785 stage II sporulation protein P; Region: spore_II_P; TIGR02867 527021005786 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 527021005787 catalytic core [active] 527021005788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021005789 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 527021005790 active site 527021005791 motif I; other site 527021005792 motif II; other site 527021005793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021005794 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021005795 MarR family; Region: MarR; pfam01047 527021005796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021005797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021005798 putative substrate translocation pore; other site 527021005799 DinB superfamily; Region: DinB_2; pfam12867 527021005800 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 527021005801 alanine racemase; Reviewed; Region: alr; PRK00053 527021005802 active site 527021005803 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 527021005804 dimer interface [polypeptide binding]; other site 527021005805 substrate binding site [chemical binding]; other site 527021005806 catalytic residues [active] 527021005807 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021005808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021005809 S-adenosylmethionine binding site [chemical binding]; other site 527021005810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005811 Coenzyme A binding pocket [chemical binding]; other site 527021005812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005813 Coenzyme A binding pocket [chemical binding]; other site 527021005814 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 527021005815 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 527021005816 glycosyltransferase, MGT family; Region: MGT; TIGR01426 527021005817 active site 527021005818 TDP-binding site; other site 527021005819 acceptor substrate-binding pocket; other site 527021005820 homodimer interface [polypeptide binding]; other site 527021005821 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021005822 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021005823 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021005824 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021005825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021005826 DNA-binding site [nucleotide binding]; DNA binding site 527021005827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021005828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021005829 homodimer interface [polypeptide binding]; other site 527021005830 catalytic residue [active] 527021005831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005832 Coenzyme A binding pocket [chemical binding]; other site 527021005833 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021005834 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 527021005835 active site 527021005836 metal binding site [ion binding]; metal-binding site 527021005837 Src Homology 3 domain superfamily; Region: SH3; cl17036 527021005838 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 527021005839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005840 Coenzyme A binding pocket [chemical binding]; other site 527021005841 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 527021005842 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021005843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005844 Coenzyme A binding pocket [chemical binding]; other site 527021005845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005846 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021005847 Coenzyme A binding pocket [chemical binding]; other site 527021005848 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 527021005849 Predicted acetyltransferase [General function prediction only]; Region: COG3393 527021005850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021005851 Coenzyme A binding pocket [chemical binding]; other site 527021005852 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 527021005853 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021005854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021005855 S-adenosylmethionine binding site [chemical binding]; other site 527021005856 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 527021005857 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 527021005858 Potassium binding sites [ion binding]; other site 527021005859 Cesium cation binding sites [ion binding]; other site 527021005860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 527021005861 DEAD-like helicases superfamily; Region: DEXDc; smart00487 527021005862 ATP binding site [chemical binding]; other site 527021005863 putative Mg++ binding site [ion binding]; other site 527021005864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021005865 nucleotide binding region [chemical binding]; other site 527021005866 ATP-binding site [chemical binding]; other site 527021005867 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 527021005868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021005869 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 527021005870 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 527021005871 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 527021005872 NADP binding site [chemical binding]; other site 527021005873 dimer interface [polypeptide binding]; other site 527021005874 RNA polymerase sigma factor; Provisional; Region: PRK12543 527021005875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021005876 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021005877 DNA binding residues [nucleotide binding] 527021005878 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 527021005879 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 527021005880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021005881 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 527021005882 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 527021005883 catalytic residues [active] 527021005884 dimer interface [polypeptide binding]; other site 527021005885 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 527021005886 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 527021005887 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 527021005888 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 527021005889 Protein of unknown function DUF58; Region: DUF58; pfam01882 527021005890 MoxR-like ATPases [General function prediction only]; Region: COG0714 527021005891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021005892 Walker A motif; other site 527021005893 ATP binding site [chemical binding]; other site 527021005894 Walker B motif; other site 527021005895 arginine finger; other site 527021005896 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 527021005897 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 527021005898 [4Fe-4S] binding site [ion binding]; other site 527021005899 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 527021005900 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 527021005901 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 527021005902 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 527021005903 molybdopterin cofactor binding site; other site 527021005904 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 527021005905 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 527021005906 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 527021005907 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 527021005908 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 527021005909 ligand binding site [chemical binding]; other site 527021005910 flexible hinge region; other site 527021005911 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 527021005912 putative switch regulator; other site 527021005913 non-specific DNA interactions [nucleotide binding]; other site 527021005914 DNA binding site [nucleotide binding] 527021005915 sequence specific DNA binding site [nucleotide binding]; other site 527021005916 putative cAMP binding site [chemical binding]; other site 527021005917 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 527021005918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021005919 FeS/SAM binding site; other site 527021005920 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 527021005921 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 527021005922 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 527021005923 ATP binding site [chemical binding]; other site 527021005924 substrate interface [chemical binding]; other site 527021005925 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 527021005926 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 527021005927 dimer interface [polypeptide binding]; other site 527021005928 putative functional site; other site 527021005929 putative MPT binding site; other site 527021005930 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 527021005931 MoaE homodimer interface [polypeptide binding]; other site 527021005932 MoaD interaction [polypeptide binding]; other site 527021005933 active site residues [active] 527021005934 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 527021005935 MoaE interaction surface [polypeptide binding]; other site 527021005936 MoeB interaction surface [polypeptide binding]; other site 527021005937 thiocarboxylated glycine; other site 527021005938 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 527021005939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021005940 putative substrate translocation pore; other site 527021005941 Predicted permeases [General function prediction only]; Region: COG0679 527021005942 precorrin-2 dehydrogenase; Validated; Region: PRK06719 527021005943 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 527021005944 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 527021005945 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 527021005946 putative active site [active] 527021005947 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 527021005948 putative active site [active] 527021005949 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 527021005950 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 527021005951 active site 527021005952 SAM binding site [chemical binding]; other site 527021005953 homodimer interface [polypeptide binding]; other site 527021005954 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 527021005955 [2Fe-2S] cluster binding site [ion binding]; other site 527021005956 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 527021005957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021005958 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 527021005959 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 527021005960 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 527021005961 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 527021005962 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 527021005963 Hemerythrin-like domain; Region: Hr-like; cd12108 527021005964 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 527021005965 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 527021005966 PGAP1-like protein; Region: PGAP1; pfam07819 527021005967 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 527021005968 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 527021005969 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 527021005970 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 527021005971 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021005972 Zn2+ binding site [ion binding]; other site 527021005973 Mg2+ binding site [ion binding]; other site 527021005974 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 527021005975 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 527021005976 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021005977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021005978 ABC transporter; Region: ABC_tran_2; pfam12848 527021005979 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021005980 Bax inhibitor 1 like; Region: BaxI_1; cl17691 527021005981 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 527021005982 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 527021005983 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 527021005984 dimer interface [polypeptide binding]; other site 527021005985 ssDNA binding site [nucleotide binding]; other site 527021005986 tetramer (dimer of dimers) interface [polypeptide binding]; other site 527021005987 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 527021005988 Virulence factor; Region: Virulence_fact; pfam13769 527021005989 HEAT repeats; Region: HEAT_2; pfam13646 527021005990 HEAT repeats; Region: HEAT_2; pfam13646 527021005991 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 527021005992 Protein of unknown function, DUF393; Region: DUF393; pfam04134 527021005993 Disulphide isomerase; Region: Disulph_isomer; pfam06491 527021005994 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 527021005995 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 527021005996 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 527021005997 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 527021005998 active site 527021005999 HIGH motif; other site 527021006000 KMSK motif region; other site 527021006001 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 527021006002 tRNA binding surface [nucleotide binding]; other site 527021006003 anticodon binding site; other site 527021006004 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021006005 Methyltransferase domain; Region: Methyltransf_12; pfam08242 527021006006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 527021006007 binding surface 527021006008 TPR motif; other site 527021006009 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 527021006010 putative active site [active] 527021006011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021006012 binding surface 527021006013 TPR motif; other site 527021006014 TPR repeat; Region: TPR_11; pfam13414 527021006015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021006016 binding surface 527021006017 TPR motif; other site 527021006018 Tetratricopeptide repeat; Region: TPR_16; pfam13432 527021006019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021006020 binding surface 527021006021 TPR motif; other site 527021006022 TPR repeat; Region: TPR_11; pfam13414 527021006023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021006024 binding surface 527021006025 TPR motif; other site 527021006026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021006027 binding surface 527021006028 TPR motif; other site 527021006029 Tetratricopeptide repeat; Region: TPR_16; pfam13432 527021006030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021006031 binding surface 527021006032 TPR motif; other site 527021006033 Tetratricopeptide repeat; Region: TPR_9; pfam13371 527021006034 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 527021006035 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 527021006036 HIGH motif; other site 527021006037 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 527021006038 active site 527021006039 KMSKS motif; other site 527021006040 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 527021006041 tRNA binding surface [nucleotide binding]; other site 527021006042 anticodon binding site; other site 527021006043 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 527021006044 Protein of unknown function (DUF418); Region: DUF418; cl12135 527021006045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021006046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021006047 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 527021006048 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 527021006049 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 527021006050 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 527021006051 Zn binding site [ion binding]; other site 527021006052 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 527021006053 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 527021006054 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 527021006055 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 527021006056 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 527021006057 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 527021006058 Dimer interface [polypeptide binding]; other site 527021006059 anticodon binding site; other site 527021006060 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 527021006061 homodimer interface [polypeptide binding]; other site 527021006062 motif 1; other site 527021006063 motif 2; other site 527021006064 active site 527021006065 motif 3; other site 527021006066 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 527021006067 metal ion-dependent adhesion site (MIDAS); other site 527021006068 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 527021006069 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 527021006070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021006071 Walker A motif; other site 527021006072 ATP binding site [chemical binding]; other site 527021006073 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 527021006074 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 527021006075 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 527021006076 active site 527021006077 ATP binding site [chemical binding]; other site 527021006078 substrate binding site [chemical binding]; other site 527021006079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021006080 binding surface 527021006081 Tetratricopeptide repeat; Region: TPR_16; pfam13432 527021006082 TPR motif; other site 527021006083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021006084 binding surface 527021006085 TPR motif; other site 527021006086 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021006087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 527021006088 binding surface 527021006089 TPR motif; other site 527021006090 SseB protein; Region: SseB; cl06279 527021006091 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 527021006092 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 527021006093 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 527021006094 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 527021006095 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 527021006096 catalytic nucleophile [active] 527021006097 Resolvase, N terminal domain; Region: Resolvase; smart00857 527021006098 catalytic residues [active] 527021006099 Recombinase; Region: Recombinase; pfam07508 527021006100 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021006101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021006102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021006103 GAD-like domain; Region: GAD-like; pfam08887 527021006104 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 527021006105 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 527021006106 Na2 binding site [ion binding]; other site 527021006107 putative substrate binding site 1 [chemical binding]; other site 527021006108 Na binding site 1 [ion binding]; other site 527021006109 putative substrate binding site 2 [chemical binding]; other site 527021006110 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021006111 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 527021006112 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 527021006113 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 527021006114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021006115 motif II; other site 527021006116 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 527021006117 fructuronate transporter; Provisional; Region: PRK10034; cl15264 527021006118 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 527021006119 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 527021006120 putative active site [active] 527021006121 metal binding site [ion binding]; metal-binding site 527021006122 aspartate racemase; Region: asp_race; TIGR00035 527021006123 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 527021006124 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 527021006125 homodimer interaction site [polypeptide binding]; other site 527021006126 cofactor binding site; other site 527021006127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021006128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021006129 Coenzyme A binding pocket [chemical binding]; other site 527021006130 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 527021006131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021006132 salt bridge; other site 527021006133 non-specific DNA binding site [nucleotide binding]; other site 527021006134 sequence-specific DNA binding site [nucleotide binding]; other site 527021006135 hypothetical protein; Validated; Region: PRK06769 527021006136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021006137 active site 527021006138 motif I; other site 527021006139 motif II; other site 527021006140 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021006141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021006142 Coenzyme A binding pocket [chemical binding]; other site 527021006143 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 527021006144 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021006145 Walker A/P-loop; other site 527021006146 ATP binding site [chemical binding]; other site 527021006147 Q-loop/lid; other site 527021006148 ABC transporter signature motif; other site 527021006149 Walker B; other site 527021006150 D-loop; other site 527021006151 H-loop/switch region; other site 527021006152 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 527021006153 YpjP-like protein; Region: YpjP; pfam14005 527021006154 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 527021006155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021006156 motif II; other site 527021006157 Phosphotransferase enzyme family; Region: APH; pfam01636 527021006158 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 527021006159 active site 527021006160 substrate binding site [chemical binding]; other site 527021006161 ATP binding site [chemical binding]; other site 527021006162 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021006163 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021006164 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 527021006165 thymidylate synthase; Region: thym_sym; TIGR03284 527021006166 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 527021006167 dimerization interface [polypeptide binding]; other site 527021006168 active site 527021006169 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 527021006170 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 527021006171 folate binding site [chemical binding]; other site 527021006172 NADP+ binding site [chemical binding]; other site 527021006173 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 527021006174 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021006175 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 527021006176 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021006177 azoreductase; Reviewed; Region: PRK00170 527021006178 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 527021006179 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 527021006180 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 527021006181 putative acyl-acceptor binding pocket; other site 527021006182 Haemolysin-III related; Region: HlyIII; cl03831 527021006183 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 527021006184 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 527021006185 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 527021006186 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 527021006187 EDD domain protein, DegV family; Region: DegV; TIGR00762 527021006188 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 527021006189 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 527021006190 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 527021006191 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 527021006192 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 527021006193 Cu(I) binding site [ion binding]; other site 527021006194 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 527021006195 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 527021006196 putative dimer interface [polypeptide binding]; other site 527021006197 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 527021006198 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 527021006199 active site 527021006200 dimer interface [polypeptide binding]; other site 527021006201 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 527021006202 Ligand Binding Site [chemical binding]; other site 527021006203 Molecular Tunnel; other site 527021006204 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021006205 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 527021006206 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 527021006207 active site 527021006208 metal binding site [ion binding]; metal-binding site 527021006209 Bacterial SH3 domain; Region: SH3_3; cl17532 527021006210 Bacterial SH3 domain; Region: SH3_3; cl17532 527021006211 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 527021006212 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 527021006213 siderophore binding site; other site 527021006214 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 527021006215 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 527021006216 homodimer interface [polypeptide binding]; other site 527021006217 substrate-cofactor binding pocket; other site 527021006218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021006219 catalytic residue [active] 527021006220 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 527021006221 FMN binding site [chemical binding]; other site 527021006222 dimer interface [polypeptide binding]; other site 527021006223 Isochorismatase family; Region: Isochorismatase; pfam00857 527021006224 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 527021006225 catalytic triad [active] 527021006226 conserved cis-peptide bond; other site 527021006227 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 527021006228 nudix motif; other site 527021006229 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 527021006230 Mechanosensitive ion channel; Region: MS_channel; pfam00924 527021006231 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 527021006232 GAF domain; Region: GAF; pfam01590 527021006233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 527021006234 Histidine kinase; Region: HisKA_3; pfam07730 527021006235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021006236 ATP binding site [chemical binding]; other site 527021006237 Mg2+ binding site [ion binding]; other site 527021006238 G-X-G motif; other site 527021006239 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021006240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021006241 active site 527021006242 phosphorylation site [posttranslational modification] 527021006243 intermolecular recognition site; other site 527021006244 dimerization interface [polypeptide binding]; other site 527021006245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021006246 DNA binding residues [nucleotide binding] 527021006247 dimerization interface [polypeptide binding]; other site 527021006248 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 527021006249 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 527021006250 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 527021006251 putative active site [active] 527021006252 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 527021006253 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 527021006254 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 527021006255 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 527021006256 NAD binding site [chemical binding]; other site 527021006257 substrate binding site [chemical binding]; other site 527021006258 catalytic Zn binding site [ion binding]; other site 527021006259 tetramer interface [polypeptide binding]; other site 527021006260 structural Zn binding site [ion binding]; other site 527021006261 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 527021006262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021006263 dimer interface [polypeptide binding]; other site 527021006264 conserved gate region; other site 527021006265 ABC-ATPase subunit interface; other site 527021006266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 527021006267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 527021006268 Integrase core domain; Region: rve; pfam00665 527021006269 transposase/IS protein; Provisional; Region: PRK09183 527021006270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021006271 Walker A motif; other site 527021006272 ATP binding site [chemical binding]; other site 527021006273 Walker B motif; other site 527021006274 arginine finger; other site 527021006275 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 527021006276 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 527021006277 N- and C-terminal domain interface [polypeptide binding]; other site 527021006278 active site 527021006279 catalytic site [active] 527021006280 metal binding site [ion binding]; metal-binding site 527021006281 carbohydrate binding site [chemical binding]; other site 527021006282 ATP binding site [chemical binding]; other site 527021006283 fructuronate transporter; Provisional; Region: PRK10034; cl15264 527021006284 GntP family permease; Region: GntP_permease; pfam02447 527021006285 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 527021006286 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 527021006287 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 527021006288 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 527021006289 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 527021006290 active site 527021006291 Predicted flavoprotein [General function prediction only]; Region: COG0431 527021006292 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 527021006293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021006294 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021006295 putative substrate translocation pore; other site 527021006296 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 527021006297 Uncharacterized conserved protein [Function unknown]; Region: COG1434 527021006298 putative active site [active] 527021006299 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 527021006300 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 527021006301 Walker A/P-loop; other site 527021006302 ATP binding site [chemical binding]; other site 527021006303 Q-loop/lid; other site 527021006304 ABC transporter signature motif; other site 527021006305 Walker B; other site 527021006306 D-loop; other site 527021006307 H-loop/switch region; other site 527021006308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021006309 dimer interface [polypeptide binding]; other site 527021006310 conserved gate region; other site 527021006311 ABC-ATPase subunit interface; other site 527021006312 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 527021006313 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 527021006314 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 527021006315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 527021006316 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 527021006317 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 527021006318 DNA binding residues [nucleotide binding] 527021006319 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 527021006320 Domain of unknown function DUF21; Region: DUF21; pfam01595 527021006321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 527021006322 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 527021006323 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 527021006324 NAD(P) binding site [chemical binding]; other site 527021006325 catalytic residues [active] 527021006326 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 527021006327 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 527021006328 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 527021006329 hypothetical protein; Provisional; Region: PRK06917 527021006330 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 527021006331 inhibitor-cofactor binding pocket; inhibition site 527021006332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021006333 catalytic residue [active] 527021006334 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 527021006335 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 527021006336 acetylornithine deacetylase; Validated; Region: PRK06915 527021006337 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 527021006338 metal binding site [ion binding]; metal-binding site 527021006339 dimer interface [polypeptide binding]; other site 527021006340 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 527021006341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021006342 Coenzyme A binding pocket [chemical binding]; other site 527021006343 PAS fold; Region: PAS_4; pfam08448 527021006344 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 527021006345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021006346 Walker A motif; other site 527021006347 ATP binding site [chemical binding]; other site 527021006348 Walker B motif; other site 527021006349 arginine finger; other site 527021006350 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 527021006351 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 527021006352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021006353 FeS/SAM binding site; other site 527021006354 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 527021006355 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 527021006356 toxin interface [polypeptide binding]; other site 527021006357 Zn binding site [ion binding]; other site 527021006358 hypothetical protein; Provisional; Region: PRK13672 527021006359 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 527021006360 YozD-like protein; Region: YozD; pfam14162 527021006361 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 527021006362 Catalytic domain of Protein Kinases; Region: PKc; cd00180 527021006363 active site 527021006364 ATP binding site [chemical binding]; other site 527021006365 substrate binding site [chemical binding]; other site 527021006366 activation loop (A-loop); other site 527021006367 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 527021006368 SpoOM protein; Region: Spo0M; pfam07070 527021006369 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 527021006370 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 527021006371 active site 527021006372 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 527021006373 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 527021006374 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 527021006375 catalytic residues [active] 527021006376 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021006377 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021006378 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 527021006379 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 527021006380 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 527021006381 active site 527021006382 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 527021006383 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 527021006384 YolD-like protein; Region: YolD; pfam08863 527021006385 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 527021006386 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 527021006387 classical (c) SDRs; Region: SDR_c; cd05233 527021006388 NAD(P) binding site [chemical binding]; other site 527021006389 active site 527021006390 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 527021006391 KTSC domain; Region: KTSC; pfam13619 527021006392 Transglycosylase; Region: Transgly; pfam00912 527021006393 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 527021006394 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021006395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021006396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021006397 putative substrate translocation pore; other site 527021006398 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 527021006399 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 527021006400 dimer interface [polypeptide binding]; other site 527021006401 Citrate synthase; Region: Citrate_synt; pfam00285 527021006402 active site 527021006403 coenzyme A binding site [chemical binding]; other site 527021006404 citrylCoA binding site [chemical binding]; other site 527021006405 oxalacetate/citrate binding site [chemical binding]; other site 527021006406 catalytic triad [active] 527021006407 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 527021006408 2-methylcitrate dehydratase; Region: prpD; TIGR02330 527021006409 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 527021006410 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 527021006411 tetramer interface [polypeptide binding]; other site 527021006412 active site 527021006413 Mg2+/Mn2+ binding site [ion binding]; other site 527021006414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 527021006415 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 527021006416 active site 527021006417 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 527021006418 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 527021006419 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 527021006420 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 527021006421 tetrameric interface [polypeptide binding]; other site 527021006422 NAD binding site [chemical binding]; other site 527021006423 catalytic residues [active] 527021006424 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 527021006425 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 527021006426 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 527021006427 substrate binding site [chemical binding]; other site 527021006428 oxyanion hole (OAH) forming residues; other site 527021006429 trimer interface [polypeptide binding]; other site 527021006430 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 527021006431 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 527021006432 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 527021006433 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 527021006434 active site 527021006435 metal binding site [ion binding]; metal-binding site 527021006436 DNA binding site [nucleotide binding] 527021006437 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 527021006438 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 527021006439 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 527021006440 Walker A/P-loop; other site 527021006441 ATP binding site [chemical binding]; other site 527021006442 Q-loop/lid; other site 527021006443 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 527021006444 ABC transporter signature motif; other site 527021006445 Walker B; other site 527021006446 D-loop; other site 527021006447 H-loop/switch region; other site 527021006448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021006449 dimerization interface [polypeptide binding]; other site 527021006450 putative DNA binding site [nucleotide binding]; other site 527021006451 putative Zn2+ binding site [ion binding]; other site 527021006452 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 527021006453 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 527021006454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021006455 putative substrate translocation pore; other site 527021006456 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 527021006457 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 527021006458 putative NAD(P) binding site [chemical binding]; other site 527021006459 active site 527021006460 isochorismate synthase DhbC; Validated; Region: PRK06923 527021006461 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 527021006462 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 527021006463 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 527021006464 acyl-activating enzyme (AAE) consensus motif; other site 527021006465 active site 527021006466 AMP binding site [chemical binding]; other site 527021006467 substrate binding site [chemical binding]; other site 527021006468 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 527021006469 hydrophobic substrate binding pocket; other site 527021006470 Isochorismatase family; Region: Isochorismatase; pfam00857 527021006471 active site 527021006472 conserved cis-peptide bond; other site 527021006473 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 527021006474 Condensation domain; Region: Condensation; pfam00668 527021006475 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 527021006476 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 527021006477 acyl-activating enzyme (AAE) consensus motif; other site 527021006478 AMP binding site [chemical binding]; other site 527021006479 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021006480 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 527021006481 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 527021006482 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 527021006483 acyl-activating enzyme (AAE) consensus motif; other site 527021006484 AMP binding site [chemical binding]; other site 527021006485 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021006486 MbtH-like protein; Region: MbtH; pfam03621 527021006487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021006488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021006489 putative substrate translocation pore; other site 527021006490 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 527021006491 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 527021006492 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 527021006493 IHF dimer interface [polypeptide binding]; other site 527021006494 IHF - DNA interface [nucleotide binding]; other site 527021006495 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 527021006496 DinB family; Region: DinB; cl17821 527021006497 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 527021006498 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 527021006499 active site 527021006500 catalytic triad [active] 527021006501 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 527021006502 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 527021006503 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 527021006504 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021006505 RNA binding surface [nucleotide binding]; other site 527021006506 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 527021006507 probable active site [active] 527021006508 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 527021006509 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 527021006510 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 527021006511 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 527021006512 active site 527021006513 dimer interface [polypeptide binding]; other site 527021006514 motif 1; other site 527021006515 motif 2; other site 527021006516 motif 3; other site 527021006517 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 527021006518 anticodon binding site; other site 527021006519 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021006520 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021006521 Walker A/P-loop; other site 527021006522 ATP binding site [chemical binding]; other site 527021006523 Q-loop/lid; other site 527021006524 ABC transporter signature motif; other site 527021006525 Walker B; other site 527021006526 D-loop; other site 527021006527 H-loop/switch region; other site 527021006528 FtsX-like permease family; Region: FtsX; pfam02687 527021006529 FtsX-like permease family; Region: FtsX; pfam02687 527021006530 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021006531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021006532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 527021006533 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 527021006534 pyruvate oxidase; Provisional; Region: PRK08611 527021006535 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 527021006536 PYR/PP interface [polypeptide binding]; other site 527021006537 dimer interface [polypeptide binding]; other site 527021006538 tetramer interface [polypeptide binding]; other site 527021006539 TPP binding site [chemical binding]; other site 527021006540 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 527021006541 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 527021006542 TPP-binding site [chemical binding]; other site 527021006543 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 527021006544 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021006545 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 527021006546 active site 527021006547 dimerization interface [polypeptide binding]; other site 527021006548 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 527021006549 Protein of unknown function, DUF606; Region: DUF606; pfam04657 527021006550 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 527021006551 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 527021006552 ligand binding site [chemical binding]; other site 527021006553 flexible hinge region; other site 527021006554 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 527021006555 Protein of unknown function, DUF606; Region: DUF606; pfam04657 527021006556 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 527021006557 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 527021006558 Transcriptional regulators [Transcription]; Region: MarR; COG1846 527021006559 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 527021006560 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 527021006561 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021006562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021006563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021006564 MMPL family; Region: MMPL; pfam03176 527021006565 MMPL family; Region: MMPL; pfam03176 527021006566 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 527021006567 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 527021006568 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 527021006569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021006570 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021006571 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021006572 Coenzyme A binding pocket [chemical binding]; other site 527021006573 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021006574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021006575 Coenzyme A binding pocket [chemical binding]; other site 527021006576 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 527021006577 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 527021006578 putative acetyltransferase YhhY; Provisional; Region: PRK10140 527021006579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021006580 Coenzyme A binding pocket [chemical binding]; other site 527021006581 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021006582 EamA-like transporter family; Region: EamA; pfam00892 527021006583 EamA-like transporter family; Region: EamA; pfam00892 527021006584 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 527021006585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021006586 non-specific DNA binding site [nucleotide binding]; other site 527021006587 salt bridge; other site 527021006588 sequence-specific DNA binding site [nucleotide binding]; other site 527021006589 Cupin domain; Region: Cupin_2; pfam07883 527021006590 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 527021006591 protoporphyrinogen oxidase; Provisional; Region: PRK12416 527021006592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 527021006593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 527021006594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021006595 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021006596 Cold-inducible protein YdjO; Region: YdjO; pfam14169 527021006597 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 527021006598 DNA-binding site [nucleotide binding]; DNA binding site 527021006599 RNA-binding motif; other site 527021006600 CAAX protease self-immunity; Region: Abi; pfam02517 527021006601 AAA domain; Region: AAA_17; pfam13207 527021006602 AAA domain; Region: AAA_18; pfam13238 527021006603 hypothetical protein; Provisional; Region: PRK06770 527021006604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021006605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021006606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 527021006607 dimerization interface [polypeptide binding]; other site 527021006608 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 527021006609 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 527021006610 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 527021006611 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 527021006612 active site 527021006613 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 527021006614 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 527021006615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021006616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 527021006617 dimerization interface [polypeptide binding]; other site 527021006618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 527021006619 MOSC domain; Region: MOSC; pfam03473 527021006620 3-alpha domain; Region: 3-alpha; pfam03475 527021006621 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 527021006622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021006623 Coenzyme A binding pocket [chemical binding]; other site 527021006624 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 527021006625 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 527021006626 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021006627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021006628 Walker A/P-loop; other site 527021006629 ATP binding site [chemical binding]; other site 527021006630 Q-loop/lid; other site 527021006631 ABC transporter signature motif; other site 527021006632 Walker B; other site 527021006633 D-loop; other site 527021006634 H-loop/switch region; other site 527021006635 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 527021006636 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021006637 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 527021006638 Walker A/P-loop; other site 527021006639 ATP binding site [chemical binding]; other site 527021006640 Q-loop/lid; other site 527021006641 ABC transporter signature motif; other site 527021006642 Walker B; other site 527021006643 D-loop; other site 527021006644 H-loop/switch region; other site 527021006645 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 527021006646 Septum formation initiator; Region: DivIC; cl17659 527021006647 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 527021006648 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 527021006649 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 527021006650 Int/Topo IB signature motif; other site 527021006651 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021006652 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 527021006653 TAP-like protein; Region: Abhydrolase_4; pfam08386 527021006654 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 527021006655 active site 527021006656 Homeodomain-like domain; Region: HTH_23; pfam13384 527021006657 Phage terminase, small subunit; Region: Terminase_4; cl01525 527021006658 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 527021006659 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 527021006660 amidase catalytic site [active] 527021006661 Zn binding residues [ion binding]; other site 527021006662 substrate binding site [chemical binding]; other site 527021006663 Bacterial SH3 domain; Region: SH3_3; cl17532 527021006664 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 527021006665 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 527021006666 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 527021006667 LysE type translocator; Region: LysE; cl00565 527021006668 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 527021006669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021006670 non-specific DNA binding site [nucleotide binding]; other site 527021006671 salt bridge; other site 527021006672 sequence-specific DNA binding site [nucleotide binding]; other site 527021006673 Cupin domain; Region: Cupin_2; pfam07883 527021006674 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 527021006675 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 527021006676 BclB C-terminal domain; Region: exospore_TM; TIGR03721 527021006677 Cupin; Region: Cupin_1; smart00835 527021006678 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 527021006679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 527021006680 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 527021006681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021006682 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 527021006683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 527021006684 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 527021006685 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 527021006686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 527021006687 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 527021006688 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 527021006689 active site 527021006690 P-loop; other site 527021006691 phosphorylation site [posttranslational modification] 527021006692 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 527021006693 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 527021006694 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 527021006695 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 527021006696 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 527021006697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 527021006698 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 527021006699 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021006700 catalytic residue [active] 527021006701 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 527021006702 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 527021006703 tetramer interface [polypeptide binding]; other site 527021006704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021006705 catalytic residue [active] 527021006706 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021006707 MarR family; Region: MarR; pfam01047 527021006708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021006709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021006710 putative substrate translocation pore; other site 527021006711 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021006712 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 527021006713 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 527021006714 ATP binding site [chemical binding]; other site 527021006715 Mg++ binding site [ion binding]; other site 527021006716 motif III; other site 527021006717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021006718 nucleotide binding region [chemical binding]; other site 527021006719 ATP-binding site [chemical binding]; other site 527021006720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021006721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021006722 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021006723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021006724 putative substrate translocation pore; other site 527021006725 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021006726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021006727 S-adenosylmethionine binding site [chemical binding]; other site 527021006728 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 527021006729 dimer interface [polypeptide binding]; other site 527021006730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021006731 S-adenosylmethionine binding site [chemical binding]; other site 527021006732 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 527021006733 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 527021006734 dimer interface [polypeptide binding]; other site 527021006735 PYR/PP interface [polypeptide binding]; other site 527021006736 TPP binding site [chemical binding]; other site 527021006737 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 527021006738 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 527021006739 TPP-binding site [chemical binding]; other site 527021006740 dimer interface [polypeptide binding]; other site 527021006741 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021006742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021006743 putative DNA binding site [nucleotide binding]; other site 527021006744 putative Zn2+ binding site [ion binding]; other site 527021006745 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 527021006746 catalytic core [active] 527021006747 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 527021006748 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 527021006749 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 527021006750 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 527021006751 metal binding site [ion binding]; metal-binding site 527021006752 dimer interface [polypeptide binding]; other site 527021006753 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 527021006754 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 527021006755 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 527021006756 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021006757 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021006758 DNA binding residues [nucleotide binding] 527021006759 dimerization interface [polypeptide binding]; other site 527021006760 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021006761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021006762 non-specific DNA binding site [nucleotide binding]; other site 527021006763 salt bridge; other site 527021006764 sequence-specific DNA binding site [nucleotide binding]; other site 527021006765 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021006766 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 527021006767 Cut8; Region: Cut8; pfam08559 527021006768 hypothetical protein; Provisional; Region: PRK10621 527021006769 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 527021006770 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 527021006771 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 527021006772 trimer interface [polypeptide binding]; other site 527021006773 active site 527021006774 substrate binding site [chemical binding]; other site 527021006775 CoA binding site [chemical binding]; other site 527021006776 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 527021006777 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021006778 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 527021006779 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 527021006780 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 527021006781 active site 527021006782 catalytic triad [active] 527021006783 oxyanion hole [active] 527021006784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021006785 putative substrate translocation pore; other site 527021006786 Condensation domain; Region: Condensation; pfam00668 527021006787 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 527021006788 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 527021006789 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 527021006790 acyl-activating enzyme (AAE) consensus motif; other site 527021006791 AMP binding site [chemical binding]; other site 527021006792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021006793 Condensation domain; Region: Condensation; pfam00668 527021006794 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 527021006795 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 527021006796 Condensation domain; Region: Condensation; pfam00668 527021006797 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 527021006798 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 527021006799 acyl-activating enzyme (AAE) consensus motif; other site 527021006800 AMP binding site [chemical binding]; other site 527021006801 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021006802 Condensation domain; Region: Condensation; pfam00668 527021006803 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 527021006804 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 527021006805 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 527021006806 acyl-activating enzyme (AAE) consensus motif; other site 527021006807 AMP binding site [chemical binding]; other site 527021006808 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021006809 Condensation domain; Region: Condensation; pfam00668 527021006810 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 527021006811 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 527021006812 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 527021006813 acyl-activating enzyme (AAE) consensus motif; other site 527021006814 AMP binding site [chemical binding]; other site 527021006815 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021006816 peptide synthase; Provisional; Region: PRK12467 527021006817 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 527021006818 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 527021006819 acyl-activating enzyme (AAE) consensus motif; other site 527021006820 AMP binding site [chemical binding]; other site 527021006821 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021006822 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 527021006823 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 527021006824 acyl-activating enzyme (AAE) consensus motif; other site 527021006825 AMP binding site [chemical binding]; other site 527021006826 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021006827 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 527021006828 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 527021006829 acyl-activating enzyme (AAE) consensus motif; other site 527021006830 AMP binding site [chemical binding]; other site 527021006831 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021006832 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 527021006833 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 527021006834 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 527021006835 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 527021006836 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 527021006837 transmembrane helices; other site 527021006838 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 527021006839 amino acid carrier protein; Region: agcS; TIGR00835 527021006840 glutaminase; Reviewed; Region: PRK12357 527021006841 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 527021006842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021006843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021006844 ATP binding site [chemical binding]; other site 527021006845 Mg2+ binding site [ion binding]; other site 527021006846 G-X-G motif; other site 527021006847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021006848 Response regulator receiver domain; Region: Response_reg; pfam00072 527021006849 active site 527021006850 phosphorylation site [posttranslational modification] 527021006851 intermolecular recognition site; other site 527021006852 dimerization interface [polypeptide binding]; other site 527021006853 YcbB domain; Region: YcbB; pfam08664 527021006854 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021006855 Spore germination protein; Region: Spore_permease; pfam03845 527021006856 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 527021006857 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 527021006858 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 527021006859 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 527021006860 amino acid transporter; Region: 2A0306; TIGR00909 527021006861 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 527021006862 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 527021006863 GIY-YIG motif/motif A; other site 527021006864 active site 527021006865 catalytic site [active] 527021006866 putative DNA binding site [nucleotide binding]; other site 527021006867 metal binding site [ion binding]; metal-binding site 527021006868 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 527021006869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021006870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021006871 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 527021006872 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 527021006873 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 527021006874 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 527021006875 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 527021006876 PAS fold; Region: PAS_4; pfam08448 527021006877 PAS domain S-box; Region: sensory_box; TIGR00229 527021006878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021006879 putative active site [active] 527021006880 heme pocket [chemical binding]; other site 527021006881 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 527021006882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021006883 putative active site [active] 527021006884 heme pocket [chemical binding]; other site 527021006885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021006886 dimer interface [polypeptide binding]; other site 527021006887 phosphorylation site [posttranslational modification] 527021006888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021006889 ATP binding site [chemical binding]; other site 527021006890 Mg2+ binding site [ion binding]; other site 527021006891 G-X-G motif; other site 527021006892 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021006893 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021006894 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 527021006895 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 527021006896 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 527021006897 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021006898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021006899 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021006900 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 527021006901 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 527021006902 active site 527021006903 nucleophile elbow; other site 527021006904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021006905 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021006906 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021006907 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 527021006908 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 527021006909 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021006910 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 527021006911 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021006912 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 527021006913 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021006914 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021006915 DNA binding residues [nucleotide binding] 527021006916 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 527021006917 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021006918 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021006919 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 527021006920 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021006921 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021006922 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021006923 beta-lactamase TEM; Provisional; Region: PRK15442 527021006924 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 527021006925 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 527021006926 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021006927 putative active site [active] 527021006928 putative metal binding site [ion binding]; other site 527021006929 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 527021006930 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021006931 Walker A/P-loop; other site 527021006932 ATP binding site [chemical binding]; other site 527021006933 Q-loop/lid; other site 527021006934 ABC transporter signature motif; other site 527021006935 Walker B; other site 527021006936 D-loop; other site 527021006937 H-loop/switch region; other site 527021006938 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 527021006939 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 527021006940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021006941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021006942 Protein of unknown function (DUF523); Region: DUF523; pfam04463 527021006943 Uncharacterized conserved protein [Function unknown]; Region: COG3272 527021006944 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 527021006945 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 527021006946 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 527021006947 FAD binding site [chemical binding]; other site 527021006948 homotetramer interface [polypeptide binding]; other site 527021006949 substrate binding pocket [chemical binding]; other site 527021006950 catalytic base [active] 527021006951 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 527021006952 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 527021006953 ATP-grasp domain; Region: ATP-grasp_4; cl17255 527021006954 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 527021006955 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 527021006956 carboxyltransferase (CT) interaction site; other site 527021006957 biotinylation site [posttranslational modification]; other site 527021006958 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 527021006959 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 527021006960 active site 527021006961 catalytic residues [active] 527021006962 metal binding site [ion binding]; metal-binding site 527021006963 enoyl-CoA hydratase; Provisional; Region: PRK07657 527021006964 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 527021006965 substrate binding site [chemical binding]; other site 527021006966 oxyanion hole (OAH) forming residues; other site 527021006967 trimer interface [polypeptide binding]; other site 527021006968 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 527021006969 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 527021006970 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 527021006971 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 527021006972 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 527021006973 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 527021006974 acyl-activating enzyme (AAE) consensus motif; other site 527021006975 putative AMP binding site [chemical binding]; other site 527021006976 putative active site [active] 527021006977 putative CoA binding site [chemical binding]; other site 527021006978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021006979 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021006980 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021006981 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 527021006982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021006983 Coenzyme A binding pocket [chemical binding]; other site 527021006984 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 527021006985 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021006986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021006987 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021006988 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 527021006989 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021006990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021006991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021006992 dimer interface [polypeptide binding]; other site 527021006993 phosphorylation site [posttranslational modification] 527021006994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021006995 ATP binding site [chemical binding]; other site 527021006996 Mg2+ binding site [ion binding]; other site 527021006997 G-X-G motif; other site 527021006998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021006999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021007000 active site 527021007001 phosphorylation site [posttranslational modification] 527021007002 intermolecular recognition site; other site 527021007003 dimerization interface [polypeptide binding]; other site 527021007004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021007005 DNA binding site [nucleotide binding] 527021007006 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021007007 Zn2+ binding site [ion binding]; other site 527021007008 Mg2+ binding site [ion binding]; other site 527021007009 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 527021007010 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 527021007011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007012 Coenzyme A binding pocket [chemical binding]; other site 527021007013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 527021007014 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 527021007015 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 527021007016 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 527021007017 active site 527021007018 Zn binding site [ion binding]; other site 527021007019 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 527021007020 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 527021007021 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 527021007022 Cna protein B-type domain; Region: Cna_B; pfam05738 527021007023 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021007024 Cna protein B-type domain; Region: Cna_B; pfam05738 527021007025 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 527021007026 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 527021007027 active site 527021007028 catalytic site [active] 527021007029 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 527021007030 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 527021007031 Cna protein B-type domain; Region: Cna_B; pfam05738 527021007032 Cna protein B-type domain; Region: Cna_B; pfam05738 527021007033 Cna protein B-type domain; Region: Cna_B; pfam05738 527021007034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 527021007035 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 527021007036 putative hydrophobic ligand binding site [chemical binding]; other site 527021007037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021007038 Walker A/P-loop; other site 527021007039 ATP binding site [chemical binding]; other site 527021007040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021007041 ABC transporter signature motif; other site 527021007042 Walker B; other site 527021007043 D-loop; other site 527021007044 H-loop/switch region; other site 527021007045 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 527021007046 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 527021007047 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 527021007048 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 527021007049 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021007050 DNA binding residues [nucleotide binding] 527021007051 drug binding residues [chemical binding]; other site 527021007052 dimer interface [polypeptide binding]; other site 527021007053 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 527021007054 short chain dehydrogenase; Provisional; Region: PRK07041 527021007055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021007056 NAD(P) binding site [chemical binding]; other site 527021007057 active site 527021007058 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 527021007059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 527021007060 Integrase core domain; Region: rve; pfam00665 527021007061 transposase/IS protein; Provisional; Region: PRK09183 527021007062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021007063 Walker A motif; other site 527021007064 ATP binding site [chemical binding]; other site 527021007065 Walker B motif; other site 527021007066 arginine finger; other site 527021007067 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021007068 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 527021007069 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021007070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021007071 S-adenosylmethionine binding site [chemical binding]; other site 527021007072 Phosphotransferase enzyme family; Region: APH; pfam01636 527021007073 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 527021007074 active site 527021007075 substrate binding site [chemical binding]; other site 527021007076 ATP binding site [chemical binding]; other site 527021007077 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 527021007078 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 527021007079 active site 527021007080 ATP binding site [chemical binding]; other site 527021007081 substrate binding site [chemical binding]; other site 527021007082 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 527021007083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021007084 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 527021007085 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 527021007086 active site 527021007087 Zn binding site [ion binding]; other site 527021007088 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 527021007089 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021007090 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021007091 DNA-binding site [nucleotide binding]; DNA binding site 527021007092 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021007093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021007094 homodimer interface [polypeptide binding]; other site 527021007095 catalytic residue [active] 527021007096 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 527021007097 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 527021007098 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 527021007099 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 527021007100 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 527021007101 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 527021007102 putative NAD(P) binding site [chemical binding]; other site 527021007103 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 527021007104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021007105 NAD(P) binding site [chemical binding]; other site 527021007106 active site 527021007107 Predicted membrane protein [Function unknown]; Region: COG2323 527021007108 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021007109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021007110 S-adenosylmethionine binding site [chemical binding]; other site 527021007111 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 527021007112 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 527021007113 conserved cys residue [active] 527021007114 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 527021007115 Strictosidine synthase; Region: Str_synth; pfam03088 527021007116 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 527021007117 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 527021007118 active site 527021007119 HIGH motif; other site 527021007120 KMSKS motif; other site 527021007121 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 527021007122 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 527021007123 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021007124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021007125 active site 527021007126 phosphorylation site [posttranslational modification] 527021007127 intermolecular recognition site; other site 527021007128 dimerization interface [polypeptide binding]; other site 527021007129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021007130 DNA binding site [nucleotide binding] 527021007131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021007132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 527021007133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021007134 ATP binding site [chemical binding]; other site 527021007135 Mg2+ binding site [ion binding]; other site 527021007136 G-X-G motif; other site 527021007137 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 527021007138 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 527021007139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021007140 ABC transporter; Region: ABC_tran_2; pfam12848 527021007141 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021007142 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021007143 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021007144 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021007145 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021007146 Walker A/P-loop; other site 527021007147 ATP binding site [chemical binding]; other site 527021007148 Q-loop/lid; other site 527021007149 ABC transporter signature motif; other site 527021007150 Walker B; other site 527021007151 D-loop; other site 527021007152 H-loop/switch region; other site 527021007153 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 527021007154 FtsX-like permease family; Region: FtsX; pfam02687 527021007155 hypothetical protein; Provisional; Region: PRK06760 527021007156 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 527021007157 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 527021007158 homoserine dehydrogenase; Validated; Region: PRK06813 527021007159 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 527021007160 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021007161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021007162 DNA-binding site [nucleotide binding]; DNA binding site 527021007163 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021007164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021007165 homodimer interface [polypeptide binding]; other site 527021007166 catalytic residue [active] 527021007167 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 527021007168 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 527021007169 ATP-grasp domain; Region: ATP-grasp_4; cl17255 527021007170 Putative transcription activator [Transcription]; Region: TenA; COG0819 527021007171 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 527021007172 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 527021007173 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 527021007174 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 527021007175 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 527021007176 Int/Topo IB signature motif; other site 527021007177 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021007178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021007179 non-specific DNA binding site [nucleotide binding]; other site 527021007180 salt bridge; other site 527021007181 sequence-specific DNA binding site [nucleotide binding]; other site 527021007182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021007183 non-specific DNA binding site [nucleotide binding]; other site 527021007184 salt bridge; other site 527021007185 sequence-specific DNA binding site [nucleotide binding]; other site 527021007186 Helix-turn-helix domain; Region: HTH_17; pfam12728 527021007187 Helix-turn-helix domain; Region: HTH_36; pfam13730 527021007188 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 527021007189 hypothetical protein; Validated; Region: PRK08116 527021007190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021007191 Walker A motif; other site 527021007192 ATP binding site [chemical binding]; other site 527021007193 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 527021007194 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 527021007195 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 527021007196 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 527021007197 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 527021007198 Septum formation initiator; Region: DivIC; cl17659 527021007199 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 527021007200 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 527021007201 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 527021007202 Int/Topo IB signature motif; other site 527021007203 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021007204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021007205 non-specific DNA binding site [nucleotide binding]; other site 527021007206 salt bridge; other site 527021007207 sequence-specific DNA binding site [nucleotide binding]; other site 527021007208 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 527021007209 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 527021007210 active site 527021007211 Homeodomain-like domain; Region: HTH_23; pfam13384 527021007212 Phage terminase, small subunit; Region: Terminase_4; cl01525 527021007213 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 527021007214 Phage portal protein; Region: Phage_portal; pfam04860 527021007215 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 527021007216 oligomer interface [polypeptide binding]; other site 527021007217 active site residues [active] 527021007218 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 527021007219 Phage capsid family; Region: Phage_capsid; pfam05065 527021007220 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 527021007221 Phage-related protein [Function unknown]; Region: COG5412 527021007222 Phage-related protein [Function unknown]; Region: COG4722 527021007223 Phage tail protein; Region: Sipho_tail; cl17486 527021007224 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 527021007225 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 527021007226 vacuolar sorting protein SNF7-like; Provisional; Region: PTZ00446 527021007227 Haemolysin XhlA; Region: XhlA; pfam10779 527021007228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021007229 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021007230 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021007231 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 527021007232 amidase catalytic site [active] 527021007233 Zn binding residues [ion binding]; other site 527021007234 substrate binding site [chemical binding]; other site 527021007235 Bacterial SH3 domain; Region: SH3_3; cl17532 527021007236 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 527021007237 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 527021007238 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 527021007239 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 527021007240 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 527021007241 Protein of unknown function; Region: DUF3658; pfam12395 527021007242 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 527021007243 Cytochrome P450; Region: p450; cl12078 527021007244 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021007245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 527021007246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021007247 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 527021007248 trimer interface [polypeptide binding]; other site 527021007249 active site 527021007250 substrate binding site [chemical binding]; other site 527021007251 CoA binding site [chemical binding]; other site 527021007252 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 527021007253 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021007254 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 527021007255 Cytochrome P450; Region: p450; cl12078 527021007256 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 527021007257 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 527021007258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021007259 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 527021007260 active site 527021007261 motif I; other site 527021007262 motif II; other site 527021007263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021007264 PAS domain S-box; Region: sensory_box; TIGR00229 527021007265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021007266 putative active site [active] 527021007267 heme pocket [chemical binding]; other site 527021007268 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 527021007269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021007270 dimer interface [polypeptide binding]; other site 527021007271 phosphorylation site [posttranslational modification] 527021007272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021007273 ATP binding site [chemical binding]; other site 527021007274 Mg2+ binding site [ion binding]; other site 527021007275 G-X-G motif; other site 527021007276 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 527021007277 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021007278 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021007279 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021007280 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021007281 Catalytic site [active] 527021007282 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 527021007283 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021007284 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 527021007285 glycosyltransferase, MGT family; Region: MGT; TIGR01426 527021007286 active site 527021007287 TDP-binding site; other site 527021007288 acceptor substrate-binding pocket; other site 527021007289 homodimer interface [polypeptide binding]; other site 527021007290 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 527021007291 aspartate racemase; Region: asp_race; TIGR00035 527021007292 hypothetical protein; Provisional; Region: PRK13661 527021007293 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 527021007294 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 527021007295 Walker A/P-loop; other site 527021007296 ATP binding site [chemical binding]; other site 527021007297 Q-loop/lid; other site 527021007298 ABC transporter signature motif; other site 527021007299 Walker B; other site 527021007300 D-loop; other site 527021007301 H-loop/switch region; other site 527021007302 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 527021007303 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 527021007304 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 527021007305 Walker A/P-loop; other site 527021007306 ATP binding site [chemical binding]; other site 527021007307 Q-loop/lid; other site 527021007308 ABC transporter signature motif; other site 527021007309 Walker B; other site 527021007310 D-loop; other site 527021007311 H-loop/switch region; other site 527021007312 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 527021007313 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 527021007314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021007315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021007316 dimer interface [polypeptide binding]; other site 527021007317 phosphorylation site [posttranslational modification] 527021007318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021007319 ATP binding site [chemical binding]; other site 527021007320 Mg2+ binding site [ion binding]; other site 527021007321 G-X-G motif; other site 527021007322 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 527021007323 nudix motif; other site 527021007324 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 527021007325 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 527021007326 active site 527021007327 ATP binding site [chemical binding]; other site 527021007328 substrate binding site [chemical binding]; other site 527021007329 activation loop (A-loop); other site 527021007330 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 527021007331 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 527021007332 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 527021007333 NAD(P) binding site [chemical binding]; other site 527021007334 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 527021007335 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 527021007336 active site 527021007337 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 527021007338 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021007339 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021007340 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 527021007341 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 527021007342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021007343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021007344 putative substrate translocation pore; other site 527021007345 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021007346 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021007347 VanZ like family; Region: VanZ; pfam04892 527021007348 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 527021007349 EDD domain protein, DegV family; Region: DegV; TIGR00762 527021007350 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 527021007351 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021007352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021007353 non-specific DNA binding site [nucleotide binding]; other site 527021007354 salt bridge; other site 527021007355 sequence-specific DNA binding site [nucleotide binding]; other site 527021007356 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 527021007357 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021007358 DNA binding residues [nucleotide binding] 527021007359 Trm112p-like protein; Region: Trm112p; pfam03966 527021007360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021007361 S-adenosylmethionine binding site [chemical binding]; other site 527021007362 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021007363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021007364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007365 Coenzyme A binding pocket [chemical binding]; other site 527021007366 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 527021007367 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 527021007368 active site 527021007369 catalytic site [active] 527021007370 metal binding site [ion binding]; metal-binding site 527021007371 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 527021007372 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021007373 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021007374 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 527021007375 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 527021007376 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021007377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021007378 DNA-binding site [nucleotide binding]; DNA binding site 527021007379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021007380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021007381 homodimer interface [polypeptide binding]; other site 527021007382 catalytic residue [active] 527021007383 EamA-like transporter family; Region: EamA; pfam00892 527021007384 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 527021007385 EamA-like transporter family; Region: EamA; pfam00892 527021007386 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 527021007387 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 527021007388 active site 527021007389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007390 Coenzyme A binding pocket [chemical binding]; other site 527021007391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 527021007392 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 527021007393 nudix motif; other site 527021007394 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 527021007395 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021007396 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021007397 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 527021007398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021007399 putative substrate translocation pore; other site 527021007400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021007401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007402 Coenzyme A binding pocket [chemical binding]; other site 527021007403 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 527021007404 nudix motif; other site 527021007405 DNA polymerase III subunit beta; Validated; Region: PRK06673 527021007406 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 527021007407 putative DNA binding surface [nucleotide binding]; other site 527021007408 dimer interface [polypeptide binding]; other site 527021007409 beta-clamp/clamp loader binding surface; other site 527021007410 beta-clamp/translesion DNA polymerase binding surface; other site 527021007411 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 527021007412 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 527021007413 translation initiation factor IF-2; Provisional; Region: PRK14845 527021007414 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 527021007415 homotrimer interaction site [polypeptide binding]; other site 527021007416 putative active site [active] 527021007417 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 527021007418 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 527021007419 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 527021007420 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 527021007421 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 527021007422 YxiJ-like protein; Region: YxiJ; pfam14176 527021007423 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 527021007424 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 527021007425 active site 527021007426 nucleophile elbow; other site 527021007427 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 527021007428 pentamer interface [polypeptide binding]; other site 527021007429 dodecaamer interface [polypeptide binding]; other site 527021007430 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021007431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007432 Coenzyme A binding pocket [chemical binding]; other site 527021007433 metal-dependent hydrolase; Provisional; Region: PRK13291 527021007434 DinB superfamily; Region: DinB_2; pfam12867 527021007435 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021007436 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021007437 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 527021007438 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 527021007439 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 527021007440 GIY-YIG motif/motif A; other site 527021007441 active site 527021007442 catalytic site [active] 527021007443 putative DNA binding site [nucleotide binding]; other site 527021007444 metal binding site [ion binding]; metal-binding site 527021007445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021007446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007447 Coenzyme A binding pocket [chemical binding]; other site 527021007448 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 527021007449 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 527021007450 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 527021007451 active site 527021007452 ATP binding site [chemical binding]; other site 527021007453 substrate binding site [chemical binding]; other site 527021007454 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 527021007455 nudix motif; other site 527021007456 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 527021007457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 527021007458 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 527021007459 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 527021007460 MepB protein; Region: MepB; pfam08877 527021007461 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 527021007462 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 527021007463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021007464 motif II; other site 527021007465 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 527021007466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021007467 active site 527021007468 phosphorylation site [posttranslational modification] 527021007469 intermolecular recognition site; other site 527021007470 dimerization interface [polypeptide binding]; other site 527021007471 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021007472 DNA binding site [nucleotide binding] 527021007473 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 527021007474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021007475 dimerization interface [polypeptide binding]; other site 527021007476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021007477 dimer interface [polypeptide binding]; other site 527021007478 phosphorylation site [posttranslational modification] 527021007479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021007480 ATP binding site [chemical binding]; other site 527021007481 Mg2+ binding site [ion binding]; other site 527021007482 G-X-G motif; other site 527021007483 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 527021007484 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 527021007485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021007486 putative DNA binding site [nucleotide binding]; other site 527021007487 putative Zn2+ binding site [ion binding]; other site 527021007488 AsnC family; Region: AsnC_trans_reg; pfam01037 527021007489 DinB superfamily; Region: DinB_2; pfam12867 527021007490 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 527021007491 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021007492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021007493 Walker A/P-loop; other site 527021007494 ATP binding site [chemical binding]; other site 527021007495 Q-loop/lid; other site 527021007496 ABC transporter signature motif; other site 527021007497 Walker B; other site 527021007498 D-loop; other site 527021007499 H-loop/switch region; other site 527021007500 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 527021007501 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 527021007502 FtsX-like permease family; Region: FtsX; pfam02687 527021007503 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021007504 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 527021007505 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 527021007506 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 527021007507 tyrosine decarboxylase; Region: PLN02880 527021007508 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 527021007509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021007510 catalytic residue [active] 527021007511 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 527021007512 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 527021007513 acyl-activating enzyme (AAE) consensus motif; other site 527021007514 AMP binding site [chemical binding]; other site 527021007515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021007516 Condensation domain; Region: Condensation; pfam00668 527021007517 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 527021007518 Nonribosomal peptide synthase; Region: NRPS; pfam08415 527021007519 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 527021007520 acyl-activating enzyme (AAE) consensus motif; other site 527021007521 AMP binding site [chemical binding]; other site 527021007522 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 527021007523 Condensation domain; Region: Condensation; pfam00668 527021007524 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 527021007525 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 527021007526 putative FMN binding site [chemical binding]; other site 527021007527 NADPH bind site [chemical binding]; other site 527021007528 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 527021007529 carbohydrate binding site [chemical binding]; other site 527021007530 pullulanase, type I; Region: pulA_typeI; TIGR02104 527021007531 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 527021007532 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 527021007533 Ca binding site [ion binding]; other site 527021007534 active site 527021007535 catalytic site [active] 527021007536 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 527021007537 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 527021007538 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 527021007539 active site 527021007540 Zn binding site [ion binding]; other site 527021007541 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 527021007542 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 527021007543 active site 527021007544 metal binding site [ion binding]; metal-binding site 527021007545 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 527021007546 DinB superfamily; Region: DinB_2; pfam12867 527021007547 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 527021007548 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 527021007549 SecY translocase; Region: SecY; pfam00344 527021007550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021007551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021007552 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 527021007553 hypothetical protein; Provisional; Region: PRK07236 527021007554 FAD binding domain; Region: FAD_binding_3; pfam01494 527021007555 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 527021007556 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 527021007557 EamA-like transporter family; Region: EamA; pfam00892 527021007558 EamA-like transporter family; Region: EamA; pfam00892 527021007559 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021007560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021007561 DNA-binding site [nucleotide binding]; DNA binding site 527021007562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021007563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021007564 homodimer interface [polypeptide binding]; other site 527021007565 catalytic residue [active] 527021007566 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 527021007567 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 527021007568 putative NAD(P) binding site [chemical binding]; other site 527021007569 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021007570 TAP-like protein; Region: Abhydrolase_4; pfam08386 527021007571 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 527021007572 Mg binding site [ion binding]; other site 527021007573 nucleotide binding site [chemical binding]; other site 527021007574 putative protofilament interface [polypeptide binding]; other site 527021007575 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 527021007576 Predicted membrane protein [Function unknown]; Region: COG4129 527021007577 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 527021007578 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021007579 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 527021007580 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 527021007581 germination protein YpeB; Region: spore_YpeB; TIGR02889 527021007582 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 527021007583 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 527021007584 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 527021007585 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 527021007586 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021007587 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021007588 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 527021007589 arylformamidase; Region: trp_arylform; TIGR03035 527021007590 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 527021007591 kynureninase; Region: kynureninase; TIGR01814 527021007592 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021007593 catalytic residue [active] 527021007594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021007595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021007596 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 527021007597 nudix motif; other site 527021007598 N-acetyltransferase; Region: Acetyltransf_2; cl00949 527021007599 Major royal jelly protein; Region: MRJP; pfam03022 527021007600 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 527021007601 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 527021007602 GAF domain; Region: GAF; pfam01590 527021007603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021007604 Walker A motif; other site 527021007605 ATP binding site [chemical binding]; other site 527021007606 Walker B motif; other site 527021007607 arginine finger; other site 527021007608 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 527021007609 NIPSNAP; Region: NIPSNAP; pfam07978 527021007610 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 527021007611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007612 Coenzyme A binding pocket [chemical binding]; other site 527021007613 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 527021007614 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 527021007615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 527021007616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021007617 S-adenosylmethionine binding site [chemical binding]; other site 527021007618 Rrf2 family protein; Region: rrf2_super; TIGR00738 527021007619 Transcriptional regulator; Region: Rrf2; pfam02082 527021007620 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 527021007621 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 527021007622 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 527021007623 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021007624 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 527021007625 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 527021007626 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 527021007627 E3 interaction surface; other site 527021007628 lipoyl attachment site [posttranslational modification]; other site 527021007629 e3 binding domain; Region: E3_binding; pfam02817 527021007630 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 527021007631 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 527021007632 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 527021007633 alpha subunit interface [polypeptide binding]; other site 527021007634 TPP binding site [chemical binding]; other site 527021007635 heterodimer interface [polypeptide binding]; other site 527021007636 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 527021007637 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 527021007638 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 527021007639 tetramer interface [polypeptide binding]; other site 527021007640 TPP-binding site [chemical binding]; other site 527021007641 heterodimer interface [polypeptide binding]; other site 527021007642 phosphorylation loop region [posttranslational modification] 527021007643 DinB superfamily; Region: DinB_2; pfam12867 527021007644 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 527021007645 short chain dehydrogenase; Provisional; Region: PRK06914 527021007646 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 527021007647 NADP binding site [chemical binding]; other site 527021007648 active site 527021007649 steroid binding site; other site 527021007650 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 527021007651 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 527021007652 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 527021007653 nudix motif; other site 527021007654 Protein phosphatase 2C; Region: PP2C_2; pfam13672 527021007655 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 527021007656 nucleotide binding site/active site [active] 527021007657 HIT family signature motif; other site 527021007658 catalytic residue [active] 527021007659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021007660 dimer interface [polypeptide binding]; other site 527021007661 conserved gate region; other site 527021007662 putative PBP binding loops; other site 527021007663 ABC-ATPase subunit interface; other site 527021007664 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 527021007665 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 527021007666 Walker A/P-loop; other site 527021007667 ATP binding site [chemical binding]; other site 527021007668 Q-loop/lid; other site 527021007669 ABC transporter signature motif; other site 527021007670 Walker B; other site 527021007671 D-loop; other site 527021007672 H-loop/switch region; other site 527021007673 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 527021007674 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 527021007675 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 527021007676 Clp protease; Region: CLP_protease; pfam00574 527021007677 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 527021007678 oligomer interface [polypeptide binding]; other site 527021007679 active site residues [active] 527021007680 RNA polymerase factor sigma-70; Validated; Region: PRK06704 527021007681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021007682 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 527021007683 DNA binding residues [nucleotide binding] 527021007684 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 527021007685 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 527021007686 catalytic loop [active] 527021007687 iron binding site [ion binding]; other site 527021007688 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 527021007689 tetramer (dimer of dimers) interface [polypeptide binding]; other site 527021007690 active site 527021007691 dimer interface [polypeptide binding]; other site 527021007692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007693 Coenzyme A binding pocket [chemical binding]; other site 527021007694 Chitin binding domain; Region: Chitin_bind_3; pfam03067 527021007695 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 527021007696 Interdomain contacts; other site 527021007697 Cytokine receptor motif; other site 527021007698 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 527021007699 Interdomain contacts; other site 527021007700 Cytokine receptor motif; other site 527021007701 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 527021007702 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 527021007703 glycosyltransferase, MGT family; Region: MGT; TIGR01426 527021007704 active site 527021007705 TDP-binding site; other site 527021007706 acceptor substrate-binding pocket; other site 527021007707 homodimer interface [polypeptide binding]; other site 527021007708 Uncharacterized conserved protein [Function unknown]; Region: COG1262 527021007709 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 527021007710 topology modulation protein; Reviewed; Region: PRK08118 527021007711 AAA domain; Region: AAA_17; pfam13207 527021007712 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 527021007713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021007714 S-adenosylmethionine binding site [chemical binding]; other site 527021007715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 527021007716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007717 Coenzyme A binding pocket [chemical binding]; other site 527021007718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007719 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021007720 Coenzyme A binding pocket [chemical binding]; other site 527021007721 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 527021007722 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 527021007723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007724 Coenzyme A binding pocket [chemical binding]; other site 527021007725 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021007726 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 527021007727 Protein of unknown function (DUF952); Region: DUF952; pfam06108 527021007728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 527021007729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007730 Coenzyme A binding pocket [chemical binding]; other site 527021007731 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 527021007732 Part of AAA domain; Region: AAA_19; pfam13245 527021007733 Family description; Region: UvrD_C_2; pfam13538 527021007734 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 527021007735 putative transposase OrfB; Reviewed; Region: PHA02517 527021007736 HTH-like domain; Region: HTH_21; pfam13276 527021007737 Integrase core domain; Region: rve; pfam00665 527021007738 Integrase core domain; Region: rve_2; pfam13333 527021007739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 527021007740 Helix-turn-helix domain; Region: HTH_28; pfam13518 527021007741 Helix-turn-helix domain; Region: HTH_28; pfam13518 527021007742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021007743 S-adenosylmethionine binding site [chemical binding]; other site 527021007744 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 527021007745 putative active site pocket [active] 527021007746 dimerization interface [polypeptide binding]; other site 527021007747 putative catalytic residue [active] 527021007748 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 527021007749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021007750 ATP binding site [chemical binding]; other site 527021007751 putative Mg++ binding site [ion binding]; other site 527021007752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021007753 nucleotide binding region [chemical binding]; other site 527021007754 ATP-binding site [chemical binding]; other site 527021007755 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 527021007756 HRDC domain; Region: HRDC; pfam00570 527021007757 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 527021007758 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 527021007759 active site 527021007760 metal binding site [ion binding]; metal-binding site 527021007761 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 527021007762 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 527021007763 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 527021007764 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 527021007765 active site 527021007766 Zn binding site [ion binding]; other site 527021007767 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 527021007768 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 527021007769 DHHA2 domain; Region: DHHA2; pfam02833 527021007770 Chitin binding domain; Region: Chitin_bind_3; pfam03067 527021007771 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021007772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007773 Coenzyme A binding pocket [chemical binding]; other site 527021007774 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021007775 Zn2+ binding site [ion binding]; other site 527021007776 Mg2+ binding site [ion binding]; other site 527021007777 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 527021007778 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 527021007779 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 527021007780 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 527021007781 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 527021007782 NAD(P) binding site [chemical binding]; other site 527021007783 catalytic residues [active] 527021007784 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 527021007785 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 527021007786 inhibitor site; inhibition site 527021007787 active site 527021007788 dimer interface [polypeptide binding]; other site 527021007789 catalytic residue [active] 527021007790 Proline racemase; Region: Pro_racemase; pfam05544 527021007791 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 527021007792 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 527021007793 Proline racemase; Region: Pro_racemase; pfam05544 527021007794 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 527021007795 hydroxyglutarate oxidase; Provisional; Region: PRK11728 527021007796 PAS domain; Region: PAS_9; pfam13426 527021007797 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 527021007798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021007799 Walker A motif; other site 527021007800 ATP binding site [chemical binding]; other site 527021007801 Walker B motif; other site 527021007802 arginine finger; other site 527021007803 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 527021007804 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 527021007805 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 527021007806 catalytic loop [active] 527021007807 iron binding site [ion binding]; other site 527021007808 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 527021007809 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 527021007810 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 527021007811 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 527021007812 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021007813 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 527021007814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021007815 Zn2+ binding site [ion binding]; other site 527021007816 Mg2+ binding site [ion binding]; other site 527021007817 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 527021007818 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 527021007819 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 527021007820 DltD N-terminal region; Region: DltD_N; pfam04915 527021007821 DltD central region; Region: DltD_M; pfam04918 527021007822 DltD C-terminal region; Region: DltD_C; pfam04914 527021007823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021007824 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021007825 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021007826 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021007827 peptide binding site [polypeptide binding]; other site 527021007828 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 527021007829 NlpC/P60 family; Region: NLPC_P60; pfam00877 527021007830 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 527021007831 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 527021007832 active site 527021007833 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 527021007834 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 527021007835 Septum formation initiator; Region: DivIC; pfam04977 527021007836 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 527021007837 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 527021007838 active site 527021007839 catalytic tetrad [active] 527021007840 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 527021007841 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 527021007842 conserved cys residue [active] 527021007843 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 527021007844 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 527021007845 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 527021007846 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021007847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021007848 S-adenosylmethionine binding site [chemical binding]; other site 527021007849 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 527021007850 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 527021007851 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 527021007852 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 527021007853 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 527021007854 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021007855 dimerization interface [polypeptide binding]; other site 527021007856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021007857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021007858 dimer interface [polypeptide binding]; other site 527021007859 phosphorylation site [posttranslational modification] 527021007860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021007861 ATP binding site [chemical binding]; other site 527021007862 Mg2+ binding site [ion binding]; other site 527021007863 G-X-G motif; other site 527021007864 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021007865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021007866 active site 527021007867 phosphorylation site [posttranslational modification] 527021007868 intermolecular recognition site; other site 527021007869 dimerization interface [polypeptide binding]; other site 527021007870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021007871 DNA binding site [nucleotide binding] 527021007872 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 527021007873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021007874 motif II; other site 527021007875 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 527021007876 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 527021007877 Phosphotransferase enzyme family; Region: APH; pfam01636 527021007878 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 527021007879 active site 527021007880 substrate binding site [chemical binding]; other site 527021007881 ATP binding site [chemical binding]; other site 527021007882 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 527021007883 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 527021007884 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 527021007885 Zn binding site [ion binding]; other site 527021007886 EDD domain protein, DegV family; Region: DegV; TIGR00762 527021007887 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 527021007888 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 527021007889 Coenzyme A binding pocket [chemical binding]; other site 527021007890 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 527021007891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021007892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021007893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021007894 putative substrate translocation pore; other site 527021007895 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 527021007896 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 527021007897 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 527021007898 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 527021007899 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 527021007900 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 527021007901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021007902 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021007903 putative substrate translocation pore; other site 527021007904 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 527021007905 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 527021007906 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 527021007907 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 527021007908 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021007909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021007910 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021007911 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 527021007912 active site 527021007913 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 527021007914 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021007915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021007916 S-adenosylmethionine binding site [chemical binding]; other site 527021007917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021007918 putative substrate translocation pore; other site 527021007919 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021007920 aspartate aminotransferase; Provisional; Region: PRK07681 527021007921 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021007922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021007923 homodimer interface [polypeptide binding]; other site 527021007924 catalytic residue [active] 527021007925 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 527021007926 pantothenate kinase; Provisional; Region: PRK13317 527021007927 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 527021007928 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 527021007929 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 527021007930 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 527021007931 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021007932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021007933 Walker A/P-loop; other site 527021007934 ATP binding site [chemical binding]; other site 527021007935 Q-loop/lid; other site 527021007936 ABC transporter signature motif; other site 527021007937 Walker B; other site 527021007938 D-loop; other site 527021007939 H-loop/switch region; other site 527021007940 Predicted transcriptional regulators [Transcription]; Region: COG1725 527021007941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021007942 DNA-binding site [nucleotide binding]; DNA binding site 527021007943 DinB family; Region: DinB; cl17821 527021007944 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 527021007945 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 527021007946 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 527021007947 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 527021007948 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 527021007949 Domain of unknown function DUF20; Region: UPF0118; pfam01594 527021007950 HNH endonuclease; Region: HNH_5; pfam14279 527021007951 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 527021007952 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 527021007953 active site 527021007954 dimer interface [polypeptide binding]; other site 527021007955 non-prolyl cis peptide bond; other site 527021007956 insertion regions; other site 527021007957 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 527021007958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 527021007959 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 527021007960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 527021007961 substrate binding pocket [chemical binding]; other site 527021007962 membrane-bound complex binding site; other site 527021007963 hinge residues; other site 527021007964 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 527021007965 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 527021007966 Walker A/P-loop; other site 527021007967 ATP binding site [chemical binding]; other site 527021007968 Q-loop/lid; other site 527021007969 ABC transporter signature motif; other site 527021007970 Walker B; other site 527021007971 D-loop; other site 527021007972 H-loop/switch region; other site 527021007973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021007974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021007975 Protein of unknown function (DUF402); Region: DUF402; pfam04167 527021007976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 527021007977 binding surface 527021007978 TPR motif; other site 527021007979 hypothetical protein; Provisional; Region: PRK09620 527021007980 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 527021007981 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 527021007982 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 527021007983 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 527021007984 DinB superfamily; Region: DinB_2; pfam12867 527021007985 Protein of unknown function (DUF664); Region: DUF664; pfam04978 527021007986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 527021007987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021007988 Coenzyme A binding pocket [chemical binding]; other site 527021007989 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021007990 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021007991 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 527021007992 active site 527021007993 NTP binding site [chemical binding]; other site 527021007994 metal binding triad [ion binding]; metal-binding site 527021007995 antibiotic binding site [chemical binding]; other site 527021007996 A new structural DNA glycosylase; Region: AlkD_like; cl11434 527021007997 active site 527021007998 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 527021007999 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 527021008000 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021008001 catalytic residue [active] 527021008002 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021008003 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 527021008004 active site 527021008005 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021008006 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 527021008007 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 527021008008 conserved cys residue [active] 527021008009 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 527021008010 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 527021008011 NodB motif; other site 527021008012 active site 527021008013 catalytic site [active] 527021008014 Zn binding site [ion binding]; other site 527021008015 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 527021008016 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 527021008017 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 527021008018 Sulfatase; Region: Sulfatase; pfam00884 527021008019 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 527021008020 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021008021 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021008022 ABC transporter; Region: ABC_tran_2; pfam12848 527021008023 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021008024 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 527021008025 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 527021008026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021008027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021008028 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 527021008029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021008030 Coenzyme A binding pocket [chemical binding]; other site 527021008031 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 527021008032 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 527021008033 hinge; other site 527021008034 active site 527021008035 prephenate dehydrogenase; Validated; Region: PRK06545 527021008036 prephenate dehydrogenase; Validated; Region: PRK08507 527021008037 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 527021008038 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 527021008039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021008040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021008041 homodimer interface [polypeptide binding]; other site 527021008042 catalytic residue [active] 527021008043 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 527021008044 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 527021008045 Tetramer interface [polypeptide binding]; other site 527021008046 active site 527021008047 FMN-binding site [chemical binding]; other site 527021008048 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 527021008049 Chorismate mutase type II; Region: CM_2; cl00693 527021008050 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 527021008051 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 527021008052 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 527021008053 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 527021008054 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 527021008055 Isochorismatase family; Region: Isochorismatase; pfam00857 527021008056 catalytic triad [active] 527021008057 conserved cis-peptide bond; other site 527021008058 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021008059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021008060 Coenzyme A binding pocket [chemical binding]; other site 527021008061 YfzA-like protein; Region: YfzA; pfam14118 527021008062 hypothetical protein; Provisional; Region: PRK06762 527021008063 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 527021008064 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021008065 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021008066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 527021008067 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 527021008068 FAD binding domain; Region: FAD_binding_4; pfam01565 527021008069 Berberine and berberine like; Region: BBE; pfam08031 527021008070 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 527021008071 malate:quinone oxidoreductase; Validated; Region: PRK05257 527021008072 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 527021008073 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 527021008074 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 527021008075 ligand binding site [chemical binding]; other site 527021008076 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 527021008077 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 527021008078 TM-ABC transporter signature motif; other site 527021008079 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 527021008080 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 527021008081 TM-ABC transporter signature motif; other site 527021008082 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 527021008083 ABC transporter signature motif; other site 527021008084 Walker B; other site 527021008085 D-loop; other site 527021008086 H-loop/switch region; other site 527021008087 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 527021008088 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 527021008089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021008090 Walker A/P-loop; other site 527021008091 ATP binding site [chemical binding]; other site 527021008092 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 527021008093 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 527021008094 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 527021008095 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 527021008096 putative N- and C-terminal domain interface [polypeptide binding]; other site 527021008097 putative active site [active] 527021008098 putative MgATP binding site [chemical binding]; other site 527021008099 catalytic site [active] 527021008100 metal binding site [ion binding]; metal-binding site 527021008101 putative carbohydrate binding site [chemical binding]; other site 527021008102 Cupin domain; Region: Cupin_2; pfam07883 527021008103 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 527021008104 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 527021008105 putative active site; other site 527021008106 catalytic residue [active] 527021008107 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021008108 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 527021008109 active site 527021008110 metal binding site [ion binding]; metal-binding site 527021008111 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 527021008112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021008113 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021008114 putative substrate translocation pore; other site 527021008115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021008116 putative DNA binding site [nucleotide binding]; other site 527021008117 putative Zn2+ binding site [ion binding]; other site 527021008118 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 527021008119 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 527021008120 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 527021008121 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 527021008122 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 527021008123 putative catalytic cysteine [active] 527021008124 gamma-glutamyl kinase; Provisional; Region: PRK05429 527021008125 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 527021008126 nucleotide binding site [chemical binding]; other site 527021008127 homotetrameric interface [polypeptide binding]; other site 527021008128 putative phosphate binding site [ion binding]; other site 527021008129 putative allosteric binding site; other site 527021008130 PUA domain; Region: PUA; pfam01472 527021008131 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 527021008132 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 527021008133 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 527021008134 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 527021008135 putative metal binding site [ion binding]; other site 527021008136 putative dimer interface [polypeptide binding]; other site 527021008137 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 527021008138 Transcriptional regulator [Transcription]; Region: IclR; COG1414 527021008139 Bacterial transcriptional regulator; Region: IclR; pfam01614 527021008140 S-methylmethionine transporter; Provisional; Region: PRK11387 527021008141 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 527021008142 active site 527021008143 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 527021008144 active site 527021008145 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021008146 MarR family; Region: MarR_2; pfam12802 527021008147 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 527021008148 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 527021008149 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 527021008150 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 527021008151 putative di-iron ligands [ion binding]; other site 527021008152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 527021008153 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 527021008154 VanW like protein; Region: VanW; pfam04294 527021008155 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 527021008156 dimer interface [polypeptide binding]; other site 527021008157 Alkaline phosphatase homologues; Region: alkPPc; smart00098 527021008158 active site 527021008159 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 527021008160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021008161 salt bridge; other site 527021008162 non-specific DNA binding site [nucleotide binding]; other site 527021008163 sequence-specific DNA binding site [nucleotide binding]; other site 527021008164 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 527021008165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021008166 motif II; other site 527021008167 uridine kinase; Provisional; Region: PRK07667 527021008168 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021008169 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021008170 Coenzyme A binding pocket [chemical binding]; other site 527021008171 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021008172 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 527021008173 active site 527021008174 metal binding site [ion binding]; metal-binding site 527021008175 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 527021008176 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021008177 Transcriptional regulator PadR-like family; Region: PadR; cl17335 527021008178 MoxR-like ATPases [General function prediction only]; Region: COG0714 527021008179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021008180 Walker A motif; other site 527021008181 ATP binding site [chemical binding]; other site 527021008182 Walker B motif; other site 527021008183 arginine finger; other site 527021008184 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 527021008185 Protein of unknown function DUF58; Region: DUF58; pfam01882 527021008186 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 527021008187 proline/glycine betaine transporter; Provisional; Region: PRK10642 527021008188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021008189 putative substrate translocation pore; other site 527021008190 acetylornithine aminotransferase; Provisional; Region: PRK02627 527021008191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 527021008192 inhibitor-cofactor binding pocket; inhibition site 527021008193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021008194 catalytic residue [active] 527021008195 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 527021008196 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 527021008197 tetramer interface [polypeptide binding]; other site 527021008198 heme binding pocket [chemical binding]; other site 527021008199 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 527021008200 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 527021008201 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 527021008202 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 527021008203 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 527021008204 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 527021008205 active site 527021008206 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 527021008207 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021008208 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021008209 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 527021008210 Uncharacterized conserved protein [Function unknown]; Region: COG1359 527021008211 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 527021008212 dimer interface [polypeptide binding]; other site 527021008213 FMN binding site [chemical binding]; other site 527021008214 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021008215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021008216 putative DNA binding site [nucleotide binding]; other site 527021008217 putative Zn2+ binding site [ion binding]; other site 527021008218 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 527021008219 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 527021008220 G1 box; other site 527021008221 putative GEF interaction site [polypeptide binding]; other site 527021008222 GTP/Mg2+ binding site [chemical binding]; other site 527021008223 Switch I region; other site 527021008224 G2 box; other site 527021008225 G3 box; other site 527021008226 Switch II region; other site 527021008227 G4 box; other site 527021008228 G5 box; other site 527021008229 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 527021008230 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 527021008231 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 527021008232 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 527021008233 nudix motif; other site 527021008234 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 527021008235 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 527021008236 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 527021008237 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 527021008238 putative NAD(P) binding site [chemical binding]; other site 527021008239 active site 527021008240 transposase/IS protein; Provisional; Region: PRK09183 527021008241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021008242 Walker A motif; other site 527021008243 ATP binding site [chemical binding]; other site 527021008244 Walker B motif; other site 527021008245 arginine finger; other site 527021008246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 527021008247 Integrase core domain; Region: rve; pfam00665 527021008248 CAAX protease self-immunity; Region: Abi; pfam02517 527021008249 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021008250 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021008251 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 527021008252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021008253 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 527021008254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021008255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021008256 Coenzyme A binding pocket [chemical binding]; other site 527021008257 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 527021008258 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 527021008259 nudix motif; other site 527021008260 EamA-like transporter family; Region: EamA; pfam00892 527021008261 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 527021008262 EamA-like transporter family; Region: EamA; pfam00892 527021008263 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021008264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021008265 DNA-binding site [nucleotide binding]; DNA binding site 527021008266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021008267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021008268 homodimer interface [polypeptide binding]; other site 527021008269 catalytic residue [active] 527021008270 hypothetical protein; Validated; Region: PRK00124 527021008271 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 527021008272 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 527021008273 uridine kinase; Validated; Region: PRK06696 527021008274 AAA domain; Region: AAA_18; pfam13238 527021008275 active site 527021008276 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 527021008277 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021008278 active site 527021008279 metal binding site [ion binding]; metal-binding site 527021008280 Phosphotransferase enzyme family; Region: APH; pfam01636 527021008281 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 527021008282 active site 527021008283 ATP binding site [chemical binding]; other site 527021008284 substrate binding site [chemical binding]; other site 527021008285 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 527021008286 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 527021008287 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 527021008288 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021008289 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021008290 Coenzyme A binding pocket [chemical binding]; other site 527021008291 lysine transporter; Provisional; Region: PRK10836 527021008292 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 527021008293 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 527021008294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021008295 HAMP domain; Region: HAMP; pfam00672 527021008296 dimerization interface [polypeptide binding]; other site 527021008297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021008298 dimer interface [polypeptide binding]; other site 527021008299 phosphorylation site [posttranslational modification] 527021008300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021008301 ATP binding site [chemical binding]; other site 527021008302 Mg2+ binding site [ion binding]; other site 527021008303 G-X-G motif; other site 527021008304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021008305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021008306 active site 527021008307 phosphorylation site [posttranslational modification] 527021008308 intermolecular recognition site; other site 527021008309 dimerization interface [polypeptide binding]; other site 527021008310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021008311 DNA binding site [nucleotide binding] 527021008312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 527021008313 FtsX-like permease family; Region: FtsX; pfam02687 527021008314 FtsX-like permease family; Region: FtsX; pfam02687 527021008315 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021008316 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021008317 Walker A/P-loop; other site 527021008318 ATP binding site [chemical binding]; other site 527021008319 Q-loop/lid; other site 527021008320 ABC transporter signature motif; other site 527021008321 Walker B; other site 527021008322 D-loop; other site 527021008323 H-loop/switch region; other site 527021008324 hypothetical protein; Provisional; Region: PRK06760; cl11698 527021008325 Methyltransferase domain; Region: Methyltransf_11; pfam08241 527021008326 S-adenosylmethionine binding site [chemical binding]; other site 527021008327 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 527021008328 putative active site [active] 527021008329 nucleotide binding site [chemical binding]; other site 527021008330 nudix motif; other site 527021008331 putative metal binding site [ion binding]; other site 527021008332 Cephalosporin hydroxylase; Region: CmcI; pfam04989 527021008333 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 527021008334 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021008335 Catalytic site [active] 527021008336 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 527021008337 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021008338 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021008339 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021008340 NAD-dependent deacetylase; Provisional; Region: PRK00481 527021008341 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 527021008342 NAD+ binding site [chemical binding]; other site 527021008343 substrate binding site [chemical binding]; other site 527021008344 Zn binding site [ion binding]; other site 527021008345 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 527021008346 putative substrate binding pocket [chemical binding]; other site 527021008347 AC domain interface; other site 527021008348 catalytic triad [active] 527021008349 AB domain interface; other site 527021008350 interchain disulfide; other site 527021008351 Predicted membrane protein [Function unknown]; Region: COG3817 527021008352 Protein of unknown function (DUF979); Region: DUF979; pfam06166 527021008353 Protein of unknown function (DUF969); Region: DUF969; pfam06149 527021008354 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 527021008355 putative active site [active] 527021008356 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 527021008357 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 527021008358 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 527021008359 Transcriptional regulator [Transcription]; Region: IclR; COG1414 527021008360 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 527021008361 Bacterial transcriptional regulator; Region: IclR; pfam01614 527021008362 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 527021008363 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 527021008364 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021008365 Catalytic site [active] 527021008366 CutC family; Region: CutC; cl01218 527021008367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021008368 dimerization interface [polypeptide binding]; other site 527021008369 putative DNA binding site [nucleotide binding]; other site 527021008370 putative Zn2+ binding site [ion binding]; other site 527021008371 DinB superfamily; Region: DinB_2; pfam12867 527021008372 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 527021008373 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 527021008374 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 527021008375 Uncharacterized conserved protein [Function unknown]; Region: COG1434 527021008376 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 527021008377 putative active site [active] 527021008378 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 527021008379 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021008380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 527021008381 Nucleoside recognition; Region: Gate; pfam07670 527021008382 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 527021008383 Phosphotransferase enzyme family; Region: APH; pfam01636 527021008384 putative active site [active] 527021008385 putative substrate binding site [chemical binding]; other site 527021008386 ATP binding site [chemical binding]; other site 527021008387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021008388 Coenzyme A binding pocket [chemical binding]; other site 527021008389 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 527021008390 Uncharacterized conserved protein [Function unknown]; Region: COG1633 527021008391 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 527021008392 dinuclear metal binding motif [ion binding]; other site 527021008393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021008394 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021008395 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 527021008396 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 527021008397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021008398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021008399 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 527021008400 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 527021008401 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021008402 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021008403 Erythromycin esterase; Region: Erythro_esteras; pfam05139 527021008404 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 527021008405 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 527021008406 putative active site [active] 527021008407 putative metal binding site [ion binding]; other site 527021008408 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 527021008409 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021008410 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 527021008411 TAP-like protein; Region: Abhydrolase_4; pfam08386 527021008412 Isochorismatase family; Region: Isochorismatase; pfam00857 527021008413 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 527021008414 catalytic triad [active] 527021008415 dimer interface [polypeptide binding]; other site 527021008416 conserved cis-peptide bond; other site 527021008417 Isochorismatase family; Region: Isochorismatase; pfam00857 527021008418 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 527021008419 catalytic triad [active] 527021008420 dimer interface [polypeptide binding]; other site 527021008421 conserved cis-peptide bond; other site 527021008422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 527021008423 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 527021008424 Amidohydrolase family; Region: Amidohydro_3; pfam07969 527021008425 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 527021008426 active site 527021008427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021008428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021008429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 527021008430 dimerization interface [polypeptide binding]; other site 527021008431 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021008432 MarR family; Region: MarR; pfam01047 527021008433 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 527021008434 Cl binding site [ion binding]; other site 527021008435 oligomer interface [polypeptide binding]; other site 527021008436 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 527021008437 plasmid segregation protein ParM; Provisional; Region: PRK13917 527021008438 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 527021008439 Mg binding site [ion binding]; other site 527021008440 nucleotide binding site [chemical binding]; other site 527021008441 putative protofilament interface [polypeptide binding]; other site 527021008442 Heat induced stress protein YflT; Region: YflT; pfam11181 527021008443 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 527021008444 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 527021008445 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 527021008446 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 527021008447 Spore germination protein; Region: Spore_permease; cl17796 527021008448 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021008449 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021008450 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 527021008451 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 527021008452 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 527021008453 TspO/MBR family; Region: TspO_MBR; pfam03073 527021008454 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 527021008455 DNA photolyase; Region: DNA_photolyase; pfam00875 527021008456 Adenoviral protein L1 52/55-kDa; Region: Adeno_52K; pfam03052 527021008457 Carbonic anhydrase; Region: Pro_CA; pfam00484 527021008458 zinc binding site [ion binding]; other site 527021008459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 527021008460 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 527021008461 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 527021008462 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 527021008463 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 527021008464 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021008465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021008466 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021008467 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 527021008468 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 527021008469 NodB motif; other site 527021008470 active site 527021008471 catalytic site [active] 527021008472 Zn binding site [ion binding]; other site 527021008473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021008474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021008475 Coenzyme A binding pocket [chemical binding]; other site 527021008476 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 527021008477 UbiA prenyltransferase family; Region: UbiA; pfam01040 527021008478 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 527021008479 Low molecular weight phosphatase family; Region: LMWPc; cd00115 527021008480 active site 527021008481 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 527021008482 arsenical-resistance protein; Region: acr3; TIGR00832 527021008483 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021008484 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 527021008485 putative metal binding site [ion binding]; other site 527021008486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021008487 dimerization interface [polypeptide binding]; other site 527021008488 putative DNA binding site [nucleotide binding]; other site 527021008489 putative Zn2+ binding site [ion binding]; other site 527021008490 DinB superfamily; Region: DinB_2; pfam12867 527021008491 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 527021008492 RibD C-terminal domain; Region: RibD_C; cl17279 527021008493 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 527021008494 sensor protein KdpD; Provisional; Region: PRK10490 527021008495 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 527021008496 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 527021008497 putative NAD(P) binding site [chemical binding]; other site 527021008498 active site 527021008499 putative substrate binding site [chemical binding]; other site 527021008500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021008501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021008502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021008503 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 527021008504 CAAX protease self-immunity; Region: Abi; pfam02517 527021008505 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021008506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021008507 Coenzyme A binding pocket [chemical binding]; other site 527021008508 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 527021008509 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 527021008510 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 527021008511 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 527021008512 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 527021008513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021008514 putative substrate translocation pore; other site 527021008515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021008516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021008517 short chain dehydrogenase; Provisional; Region: PRK12746 527021008518 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 527021008519 NADP binding site [chemical binding]; other site 527021008520 homodimer interface [polypeptide binding]; other site 527021008521 active site 527021008522 substrate binding site [chemical binding]; other site 527021008523 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 527021008524 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021008525 putative DNA binding site [nucleotide binding]; other site 527021008526 putative Zn2+ binding site [ion binding]; other site 527021008527 AsnC family; Region: AsnC_trans_reg; pfam01037 527021008528 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 527021008529 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 527021008530 metal binding site [ion binding]; metal-binding site 527021008531 AAA domain; Region: AAA_11; pfam13086 527021008532 Part of AAA domain; Region: AAA_19; pfam13245 527021008533 Erp protein C-terminus; Region: Erp_C; pfam06780 527021008534 AAA domain; Region: AAA_30; pfam13604 527021008535 AAA domain; Region: AAA_12; pfam13087 527021008536 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 527021008537 putative active site [active] 527021008538 catalytic site [active] 527021008539 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021008540 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 527021008541 active site 527021008542 metal binding site [ion binding]; metal-binding site 527021008543 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 527021008544 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 527021008545 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 527021008546 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 527021008547 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021008548 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021008549 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021008550 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021008551 putative monooxygenase; Provisional; Region: PRK11118 527021008552 DoxX-like family; Region: DoxX_2; pfam13564 527021008553 Transcriptional regulators [Transcription]; Region: MarR; COG1846 527021008554 MarR family; Region: MarR_2; pfam12802 527021008555 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 527021008556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021008557 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021008558 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021008559 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 527021008560 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 527021008561 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 527021008562 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021008563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021008564 active site 527021008565 phosphorylation site [posttranslational modification] 527021008566 intermolecular recognition site; other site 527021008567 dimerization interface [polypeptide binding]; other site 527021008568 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021008569 DNA binding site [nucleotide binding] 527021008570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021008571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021008572 dimerization interface [polypeptide binding]; other site 527021008573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021008574 dimer interface [polypeptide binding]; other site 527021008575 phosphorylation site [posttranslational modification] 527021008576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021008577 ATP binding site [chemical binding]; other site 527021008578 G-X-G motif; other site 527021008579 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 527021008580 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 527021008581 CAAX protease self-immunity; Region: Abi; pfam02517 527021008582 Erythromycin esterase; Region: Erythro_esteras; pfam05139 527021008583 Putative sensor; Region: Sensor; pfam13796 527021008584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 527021008585 Histidine kinase; Region: HisKA_3; pfam07730 527021008586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021008587 ATP binding site [chemical binding]; other site 527021008588 Mg2+ binding site [ion binding]; other site 527021008589 G-X-G motif; other site 527021008590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021008591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021008592 active site 527021008593 phosphorylation site [posttranslational modification] 527021008594 intermolecular recognition site; other site 527021008595 dimerization interface [polypeptide binding]; other site 527021008596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021008597 DNA binding residues [nucleotide binding] 527021008598 dimerization interface [polypeptide binding]; other site 527021008599 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 527021008600 FtsX-like permease family; Region: FtsX; pfam02687 527021008601 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021008602 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021008603 Walker A/P-loop; other site 527021008604 ATP binding site [chemical binding]; other site 527021008605 Q-loop/lid; other site 527021008606 ABC transporter signature motif; other site 527021008607 Walker B; other site 527021008608 D-loop; other site 527021008609 H-loop/switch region; other site 527021008610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021008611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021008612 dimer interface [polypeptide binding]; other site 527021008613 phosphorylation site [posttranslational modification] 527021008614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021008615 ATP binding site [chemical binding]; other site 527021008616 Mg2+ binding site [ion binding]; other site 527021008617 G-X-G motif; other site 527021008618 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021008619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021008620 active site 527021008621 phosphorylation site [posttranslational modification] 527021008622 intermolecular recognition site; other site 527021008623 dimerization interface [polypeptide binding]; other site 527021008624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021008625 DNA binding site [nucleotide binding] 527021008626 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 527021008627 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 527021008628 putative metal binding site [ion binding]; other site 527021008629 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 527021008630 Cytochrome P450; Region: p450; pfam00067 527021008631 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 527021008632 Flavodoxin; Region: Flavodoxin_1; pfam00258 527021008633 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 527021008634 FAD binding pocket [chemical binding]; other site 527021008635 FAD binding motif [chemical binding]; other site 527021008636 catalytic residues [active] 527021008637 NAD binding pocket [chemical binding]; other site 527021008638 phosphate binding motif [ion binding]; other site 527021008639 beta-alpha-beta structure motif; other site 527021008640 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 527021008641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021008642 putative substrate translocation pore; other site 527021008643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021008644 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 527021008645 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 527021008646 D-cysteine desulfhydrase; Validated; Region: PRK03910 527021008647 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 527021008648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021008649 catalytic residue [active] 527021008650 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 527021008651 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021008652 active site 527021008653 metal binding site [ion binding]; metal-binding site 527021008654 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 527021008655 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 527021008656 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 527021008657 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 527021008658 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 527021008659 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 527021008660 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 527021008661 hypothetical protein; Provisional; Region: PRK06762 527021008662 AAA domain; Region: AAA_33; pfam13671 527021008663 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 527021008664 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 527021008665 FAD binding domain; Region: FAD_binding_4; pfam01565 527021008666 Berberine and berberine like; Region: BBE; pfam08031 527021008667 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021008668 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021008669 Walker A/P-loop; other site 527021008670 ATP binding site [chemical binding]; other site 527021008671 Q-loop/lid; other site 527021008672 ABC transporter signature motif; other site 527021008673 Walker B; other site 527021008674 D-loop; other site 527021008675 H-loop/switch region; other site 527021008676 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 527021008677 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 527021008678 FtsX-like permease family; Region: FtsX; pfam02687 527021008679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021008680 dimerization interface [polypeptide binding]; other site 527021008681 putative DNA binding site [nucleotide binding]; other site 527021008682 Predicted transcriptional regulator [Transcription]; Region: COG2345 527021008683 putative Zn2+ binding site [ion binding]; other site 527021008684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021008685 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021008686 putative substrate translocation pore; other site 527021008687 DinB superfamily; Region: DinB_2; pfam12867 527021008688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021008689 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021008690 dimerization interface [polypeptide binding]; other site 527021008691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021008692 dimer interface [polypeptide binding]; other site 527021008693 phosphorylation site [posttranslational modification] 527021008694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021008695 ATP binding site [chemical binding]; other site 527021008696 Mg2+ binding site [ion binding]; other site 527021008697 G-X-G motif; other site 527021008698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021008699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021008700 active site 527021008701 phosphorylation site [posttranslational modification] 527021008702 intermolecular recognition site; other site 527021008703 dimerization interface [polypeptide binding]; other site 527021008704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021008705 DNA binding site [nucleotide binding] 527021008706 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021008707 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021008708 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021008709 2TM domain; Region: 2TM; pfam13239 527021008710 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 527021008711 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 527021008712 putative dimer interface [polypeptide binding]; other site 527021008713 catalytic triad [active] 527021008714 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 527021008715 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 527021008716 dimer interaction site [polypeptide binding]; other site 527021008717 substrate-binding tunnel; other site 527021008718 active site 527021008719 catalytic site [active] 527021008720 substrate binding site [chemical binding]; other site 527021008721 Uncharacterized conserved protein [Function unknown]; Region: COG4198 527021008722 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 527021008723 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 527021008724 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 527021008725 putative ligand binding site [chemical binding]; other site 527021008726 putative NAD binding site [chemical binding]; other site 527021008727 putative catalytic site [active] 527021008728 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 527021008729 L-serine binding site [chemical binding]; other site 527021008730 ACT domain interface; other site 527021008731 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 527021008732 homodimer interface [polypeptide binding]; other site 527021008733 substrate-cofactor binding pocket; other site 527021008734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021008735 catalytic residue [active] 527021008736 Domain of unknown function (DUF378); Region: DUF378; cl00943 527021008737 Cupin domain; Region: Cupin_2; cl17218 527021008738 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 527021008739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021008740 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 527021008741 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 527021008742 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 527021008743 active site 527021008744 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 527021008745 substrate binding site [chemical binding]; other site 527021008746 amidase catalytic site [active] 527021008747 Zn binding residues [ion binding]; other site 527021008748 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021008749 S-layer homology domain; Region: SLH; pfam00395 527021008750 S-layer homology domain; Region: SLH; pfam00395 527021008751 S-layer homology domain; Region: SLH; pfam00395 527021008752 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 527021008753 A new structural DNA glycosylase; Region: AlkD_like; cd06561 527021008754 active site 527021008755 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 527021008756 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 527021008757 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 527021008758 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 527021008759 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 527021008760 putative active site [active] 527021008761 putative metal binding site [ion binding]; other site 527021008762 NETI protein; Region: NETI; pfam14044 527021008763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021008764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021008765 putative substrate translocation pore; other site 527021008766 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021008767 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 527021008768 TAP-like protein; Region: Abhydrolase_4; pfam08386 527021008769 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021008770 MarR family; Region: MarR_2; pfam12802 527021008771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021008772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021008773 putative substrate translocation pore; other site 527021008774 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021008775 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021008776 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021008777 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021008778 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 527021008779 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 527021008780 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 527021008781 SWIM zinc finger; Region: SWIM; pfam04434 527021008782 YwiC-like protein; Region: YwiC; pfam14256 527021008783 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 527021008784 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 527021008785 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 527021008786 Walker A/P-loop; other site 527021008787 ATP binding site [chemical binding]; other site 527021008788 Q-loop/lid; other site 527021008789 ABC transporter signature motif; other site 527021008790 Walker B; other site 527021008791 D-loop; other site 527021008792 H-loop/switch region; other site 527021008793 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 527021008794 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 527021008795 Walker A/P-loop; other site 527021008796 ATP binding site [chemical binding]; other site 527021008797 Q-loop/lid; other site 527021008798 ABC transporter signature motif; other site 527021008799 Walker B; other site 527021008800 D-loop; other site 527021008801 H-loop/switch region; other site 527021008802 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 527021008803 Calreticulin family; Region: Calreticulin; pfam00262 527021008804 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 527021008805 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 527021008806 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 527021008807 Predicted membrane protein [Function unknown]; Region: COG1288 527021008808 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 527021008809 Endonuclease I; Region: Endonuclease_1; pfam04231 527021008810 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 527021008811 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 527021008812 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 527021008813 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 527021008814 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021008815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021008816 non-specific DNA binding site [nucleotide binding]; other site 527021008817 salt bridge; other site 527021008818 sequence-specific DNA binding site [nucleotide binding]; other site 527021008819 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 527021008820 putative deacylase active site [active] 527021008821 histidyl-tRNA synthetase; Provisional; Region: PRK12420 527021008822 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 527021008823 dimer interface [polypeptide binding]; other site 527021008824 motif 1; other site 527021008825 active site 527021008826 motif 2; other site 527021008827 motif 3; other site 527021008828 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 527021008829 anticodon binding site; other site 527021008830 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021008831 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 527021008832 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 527021008833 dimer interface [polypeptide binding]; other site 527021008834 FMN binding site [chemical binding]; other site 527021008835 pyruvate kinase; Validated; Region: PRK06739 527021008836 active site 527021008837 domain interfaces; other site 527021008838 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 527021008839 classical (c) SDRs; Region: SDR_c; cd05233 527021008840 NAD(P) binding site [chemical binding]; other site 527021008841 active site 527021008842 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 527021008843 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021008844 Walker A/P-loop; other site 527021008845 ATP binding site [chemical binding]; other site 527021008846 Q-loop/lid; other site 527021008847 ABC transporter signature motif; other site 527021008848 Walker B; other site 527021008849 D-loop; other site 527021008850 H-loop/switch region; other site 527021008851 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 527021008852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021008853 non-specific DNA binding site [nucleotide binding]; other site 527021008854 salt bridge; other site 527021008855 sequence-specific DNA binding site [nucleotide binding]; other site 527021008856 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 527021008857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021008858 motif II; other site 527021008859 Phosphotransferase enzyme family; Region: APH; pfam01636 527021008860 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 527021008861 active site 527021008862 ATP binding site [chemical binding]; other site 527021008863 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 527021008864 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 527021008865 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021008866 Coenzyme A binding pocket [chemical binding]; other site 527021008867 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 527021008868 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 527021008869 nudix motif; other site 527021008870 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 527021008871 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 527021008872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021008873 putative metal binding site [ion binding]; other site 527021008874 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 527021008875 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 527021008876 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 527021008877 Probable transposase; Region: OrfB_IS605; pfam01385 527021008878 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 527021008879 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 527021008880 maltose O-acetyltransferase; Provisional; Region: PRK10092 527021008881 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 527021008882 active site 527021008883 substrate binding site [chemical binding]; other site 527021008884 trimer interface [polypeptide binding]; other site 527021008885 CoA binding site [chemical binding]; other site 527021008886 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 527021008887 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 527021008888 active site 527021008889 HIGH motif; other site 527021008890 dimer interface [polypeptide binding]; other site 527021008891 KMSKS motif; other site 527021008892 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 527021008893 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 527021008894 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 527021008895 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 527021008896 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 527021008897 Domain of unknown function DUF20; Region: UPF0118; pfam01594 527021008898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021008899 Coenzyme A binding pocket [chemical binding]; other site 527021008900 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021008901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021008902 S-adenosylmethionine binding site [chemical binding]; other site 527021008903 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 527021008904 CGNR zinc finger; Region: zf-CGNR; pfam11706 527021008905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021008906 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021008907 putative substrate translocation pore; other site 527021008908 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 527021008909 hypothetical protein; Provisional; Region: PRK04164 527021008910 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021008911 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 527021008912 Domain of unknown function DUF21; Region: DUF21; pfam01595 527021008913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 527021008914 Transporter associated domain; Region: CorC_HlyC; smart01091 527021008915 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 527021008916 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 527021008917 DNA binding residues [nucleotide binding] 527021008918 putative dimer interface [polypeptide binding]; other site 527021008919 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 527021008920 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 527021008921 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 527021008922 substrate binding site; other site 527021008923 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 527021008924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021008925 NAD(P) binding site [chemical binding]; other site 527021008926 active site 527021008927 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 527021008928 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021008929 Methyltransferase domain; Region: Methyltransf_12; pfam08242 527021008930 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 527021008931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021008932 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 527021008933 NAD(P) binding site [chemical binding]; other site 527021008934 active site 527021008935 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 527021008936 Src Homology 3 domain superfamily; Region: SH3; cl17036 527021008937 EamA-like transporter family; Region: EamA; pfam00892 527021008938 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 527021008939 EamA-like transporter family; Region: EamA; pfam00892 527021008940 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 527021008941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 527021008942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 527021008943 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 527021008944 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 527021008945 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 527021008946 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 527021008947 N- and C-terminal domain interface [polypeptide binding]; other site 527021008948 active site 527021008949 catalytic site [active] 527021008950 metal binding site [ion binding]; metal-binding site 527021008951 carbohydrate binding site [chemical binding]; other site 527021008952 ATP binding site [chemical binding]; other site 527021008953 GntP family permease; Region: GntP_permease; pfam02447 527021008954 fructuronate transporter; Provisional; Region: PRK10034; cl15264 527021008955 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 527021008956 active site 527021008957 intersubunit interactions; other site 527021008958 catalytic residue [active] 527021008959 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 527021008960 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 527021008961 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 527021008962 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 527021008963 TPP-binding site [chemical binding]; other site 527021008964 dimer interface [polypeptide binding]; other site 527021008965 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 527021008966 PYR/PP interface [polypeptide binding]; other site 527021008967 dimer interface [polypeptide binding]; other site 527021008968 TPP binding site [chemical binding]; other site 527021008969 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 527021008970 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 527021008971 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 527021008972 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 527021008973 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 527021008974 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 527021008975 putative NAD(P) binding site [chemical binding]; other site 527021008976 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 527021008977 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 527021008978 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 527021008979 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 527021008980 putative NAD(P) binding site [chemical binding]; other site 527021008981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 527021008982 classical (c) SDRs; Region: SDR_c; cd05233 527021008983 NAD(P) binding site [chemical binding]; other site 527021008984 active site 527021008985 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 527021008986 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 527021008987 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 527021008988 active site 527021008989 Zn binding site [ion binding]; other site 527021008990 Viral enhancin protein; Region: Enhancin; pfam03272 527021008991 Peptidase M60-like family; Region: M60-like; pfam13402 527021008992 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 527021008993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021008994 dimerization interface [polypeptide binding]; other site 527021008995 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021008996 dimer interface [polypeptide binding]; other site 527021008997 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 527021008998 putative CheW interface [polypeptide binding]; other site 527021008999 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 527021009000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021009001 motif II; other site 527021009002 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 527021009003 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 527021009004 catalytic motif [active] 527021009005 Zn binding site [ion binding]; other site 527021009006 RibD C-terminal domain; Region: RibD_C; cl17279 527021009007 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 527021009008 dimerization interface [polypeptide binding]; other site 527021009009 active site 527021009010 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021009011 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 527021009012 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 527021009013 dimer interface [polypeptide binding]; other site 527021009014 FMN binding site [chemical binding]; other site 527021009015 BNR repeat-like domain; Region: BNR_2; pfam13088 527021009016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 527021009017 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 527021009018 active site 527021009019 catalytic tetrad [active] 527021009020 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 527021009021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021009022 putative substrate translocation pore; other site 527021009023 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 527021009024 active site 1 [active] 527021009025 dimer interface [polypeptide binding]; other site 527021009026 hexamer interface [polypeptide binding]; other site 527021009027 active site 2 [active] 527021009028 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 527021009029 hexamer interface [polypeptide binding]; other site 527021009030 active site 2 [active] 527021009031 hypothetical protein; Provisional; Region: PRK02487 527021009032 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 527021009033 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 527021009034 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 527021009035 PhnA protein; Region: PhnA; pfam03831 527021009036 putative transporter; Provisional; Region: PRK11660 527021009037 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 527021009038 Sulfate transporter family; Region: Sulfate_transp; pfam00916 527021009039 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 527021009040 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021009041 dimerization interface [polypeptide binding]; other site 527021009042 putative DNA binding site [nucleotide binding]; other site 527021009043 putative Zn2+ binding site [ion binding]; other site 527021009044 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 527021009045 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 527021009046 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 527021009047 IDEAL domain; Region: IDEAL; pfam08858 527021009048 Transcriptional regulator; Region: Rrf2; pfam02082 527021009049 Rrf2 family protein; Region: rrf2_super; TIGR00738 527021009050 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 527021009051 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 527021009052 ArsC family; Region: ArsC; pfam03960 527021009053 putative catalytic residues [active] 527021009054 thiol/disulfide switch; other site 527021009055 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021009056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021009057 dimerization interface [polypeptide binding]; other site 527021009058 putative DNA binding site [nucleotide binding]; other site 527021009059 putative Zn2+ binding site [ion binding]; other site 527021009060 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 527021009061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021009062 DNA-binding site [nucleotide binding]; DNA binding site 527021009063 UTRA domain; Region: UTRA; pfam07702 527021009064 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021009065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021009066 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021009067 putative oxidoreductase; Provisional; Region: PRK10206 527021009068 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 527021009069 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 527021009070 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 527021009071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 527021009072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021009073 S-adenosylmethionine binding site [chemical binding]; other site 527021009074 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021009075 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021009076 dimerization interface [polypeptide binding]; other site 527021009077 putative DNA binding site [nucleotide binding]; other site 527021009078 putative Zn2+ binding site [ion binding]; other site 527021009079 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021009080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021009081 dimerization interface [polypeptide binding]; other site 527021009082 putative DNA binding site [nucleotide binding]; other site 527021009083 putative Zn2+ binding site [ion binding]; other site 527021009084 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 527021009085 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 527021009086 active site 527021009087 catalytic tetrad [active] 527021009088 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 527021009089 putative hydrophobic ligand binding site [chemical binding]; other site 527021009090 protein interface [polypeptide binding]; other site 527021009091 gate; other site 527021009092 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 527021009093 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 527021009094 putative active site [active] 527021009095 putative catalytic triad [active] 527021009096 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 527021009097 catalytic triad [active] 527021009098 oxyanion hole [active] 527021009099 active site 527021009100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021009101 Phosphotransferase enzyme family; Region: APH; pfam01636 527021009102 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 527021009103 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 527021009104 Uncharacterized conserved protein [Function unknown]; Region: COG0327 527021009105 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 527021009106 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 527021009107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021009108 Coenzyme A binding pocket [chemical binding]; other site 527021009109 C factor cell-cell signaling protein; Provisional; Region: PRK09009 527021009110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021009111 NAD(P) binding site [chemical binding]; other site 527021009112 active site 527021009113 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 527021009114 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021009115 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 527021009116 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 527021009117 acyl-activating enzyme (AAE) consensus motif; other site 527021009118 AMP binding site [chemical binding]; other site 527021009119 active site 527021009120 CoA binding site [chemical binding]; other site 527021009121 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 527021009122 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021009123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021009124 dimerization interface [polypeptide binding]; other site 527021009125 putative DNA binding site [nucleotide binding]; other site 527021009126 putative Zn2+ binding site [ion binding]; other site 527021009127 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021009128 dimerization interface [polypeptide binding]; other site 527021009129 putative DNA binding site [nucleotide binding]; other site 527021009130 putative Zn2+ binding site [ion binding]; other site 527021009131 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 527021009132 active site 527021009133 Glyco_18 domain; Region: Glyco_18; smart00636 527021009134 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 527021009135 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 527021009136 NodB motif; other site 527021009137 putative active site [active] 527021009138 putative catalytic site [active] 527021009139 putative Zn binding site [ion binding]; other site 527021009140 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 527021009141 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 527021009142 DXD motif; other site 527021009143 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 527021009144 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 527021009145 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021009146 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 527021009147 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 527021009148 active site 527021009149 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 527021009150 VPS10 domain; Region: VPS10; smart00602 527021009151 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 527021009152 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 527021009153 HTH domain; Region: HTH_11; pfam08279 527021009154 WYL domain; Region: WYL; pfam13280 527021009155 ABC-2 type transporter; Region: ABC2_membrane; cl17235 527021009156 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 527021009157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021009158 Walker A/P-loop; other site 527021009159 ATP binding site [chemical binding]; other site 527021009160 Q-loop/lid; other site 527021009161 ABC transporter signature motif; other site 527021009162 Walker B; other site 527021009163 D-loop; other site 527021009164 H-loop/switch region; other site 527021009165 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 527021009166 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021009167 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 527021009168 hydroxylamine reductase; Provisional; Region: PRK12310 527021009169 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 527021009170 ACS interaction site; other site 527021009171 CODH interaction site; other site 527021009172 metal cluster binding site [ion binding]; other site 527021009173 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021009174 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 527021009175 active site 527021009176 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 527021009177 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 527021009178 metal binding site [ion binding]; metal-binding site 527021009179 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 527021009180 hypothetical protein; Provisional; Region: PRK06771 527021009181 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021009182 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021009183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 527021009184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 527021009185 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 527021009186 dimer interface [polypeptide binding]; other site 527021009187 ligand binding site [chemical binding]; other site 527021009188 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 527021009189 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 527021009190 ligand binding site [chemical binding]; other site 527021009191 flexible hinge region; other site 527021009192 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 527021009193 Protein of unknown function, DUF606; Region: DUF606; pfam04657 527021009194 Protein of unknown function, DUF606; Region: DUF606; pfam04657 527021009195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021009196 putative transport protein YifK; Provisional; Region: PRK10746 527021009197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021009198 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 527021009199 putative substrate translocation pore; other site 527021009200 Haemolysin XhlA; Region: XhlA; pfam10779 527021009201 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 527021009202 classical (c) SDRs; Region: SDR_c; cd05233 527021009203 NAD(P) binding site [chemical binding]; other site 527021009204 active site 527021009205 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 527021009206 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 527021009207 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 527021009208 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 527021009209 transmembrane helices; other site 527021009210 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 527021009211 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021009212 Coenzyme A binding pocket [chemical binding]; other site 527021009213 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 527021009214 putative ligand binding residues [chemical binding]; other site 527021009215 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 527021009216 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 527021009217 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021009218 ABC-ATPase subunit interface; other site 527021009219 dimer interface [polypeptide binding]; other site 527021009220 putative PBP binding regions; other site 527021009221 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 527021009222 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021009223 ABC-ATPase subunit interface; other site 527021009224 dimer interface [polypeptide binding]; other site 527021009225 putative PBP binding regions; other site 527021009226 Protein of unknown function (DUF817); Region: DUF817; pfam05675 527021009227 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 527021009228 DinB superfamily; Region: DinB_2; pfam12867 527021009229 DinB family; Region: DinB; cl17821 527021009230 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 527021009231 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 527021009232 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021009233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021009234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 527021009235 dimerization interface [polypeptide binding]; other site 527021009236 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 527021009237 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 527021009238 NADP binding site [chemical binding]; other site 527021009239 dimer interface [polypeptide binding]; other site 527021009240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 527021009241 catalytic core [active] 527021009242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021009243 Coenzyme A binding pocket [chemical binding]; other site 527021009244 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 527021009245 MutS domain III; Region: MutS_III; pfam05192 527021009246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021009247 Walker A/P-loop; other site 527021009248 ATP binding site [chemical binding]; other site 527021009249 Q-loop/lid; other site 527021009250 ABC transporter signature motif; other site 527021009251 Walker B; other site 527021009252 D-loop; other site 527021009253 H-loop/switch region; other site 527021009254 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 527021009255 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 527021009256 active site 527021009257 Na/Ca binding site [ion binding]; other site 527021009258 catalytic site [active] 527021009259 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 527021009260 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 527021009261 oligoendopeptidase F; Region: pepF; TIGR00181 527021009262 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 527021009263 active site 527021009264 Zn binding site [ion binding]; other site 527021009265 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 527021009266 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 527021009267 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 527021009268 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021009269 DNA binding residues [nucleotide binding] 527021009270 drug binding residues [chemical binding]; other site 527021009271 dimer interface [polypeptide binding]; other site 527021009272 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 527021009273 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 527021009274 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 527021009275 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 527021009276 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 527021009277 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 527021009278 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021009279 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021009280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021009281 putative substrate translocation pore; other site 527021009282 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021009283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021009284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021009285 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 527021009286 putative dimerization interface [polypeptide binding]; other site 527021009287 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 527021009288 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 527021009289 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 527021009290 active site 527021009291 catalytic site [active] 527021009292 metal binding site [ion binding]; metal-binding site 527021009293 FAD binding domain; Region: FAD_binding_3; pfam01494 527021009294 hypothetical protein; Provisional; Region: PRK07236 527021009295 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 527021009296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021009297 dimerization interface [polypeptide binding]; other site 527021009298 putative DNA binding site [nucleotide binding]; other site 527021009299 putative Zn2+ binding site [ion binding]; other site 527021009300 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 527021009301 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 527021009302 putative NAD(P) binding site [chemical binding]; other site 527021009303 Uncharacterized conserved protein [Function unknown]; Region: COG0397 527021009304 hypothetical protein; Validated; Region: PRK00029 527021009305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 527021009306 TPR motif; other site 527021009307 binding surface 527021009308 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021009309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021009310 TPR motif; other site 527021009311 binding surface 527021009312 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 527021009313 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 527021009314 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 527021009315 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 527021009316 FAD binding domain; Region: FAD_binding_4; pfam01565 527021009317 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 527021009318 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021009319 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021009320 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 527021009321 active site residue [active] 527021009322 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 527021009323 active site 527021009324 catalytic site [active] 527021009325 putative metal binding site [ion binding]; other site 527021009326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 527021009327 Chitin binding domain; Region: Chitin_bind_3; pfam03067 527021009328 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 527021009329 Interdomain contacts; other site 527021009330 Cytokine receptor motif; other site 527021009331 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 527021009332 Interdomain contacts; other site 527021009333 Cytokine receptor motif; other site 527021009334 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 527021009335 Fic/DOC family; Region: Fic; pfam02661 527021009336 Fic family protein [Function unknown]; Region: COG3177 527021009337 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021009338 Spore germination protein; Region: Spore_permease; cl17796 527021009339 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 527021009340 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 527021009341 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 527021009342 PKC phosphorylation site [posttranslational modification]; other site 527021009343 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 527021009344 Peptidase M60-like family; Region: M60-like; pfam13402 527021009345 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 527021009346 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 527021009347 Interdomain contacts; other site 527021009348 Cytokine receptor motif; other site 527021009349 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 527021009350 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 527021009351 PAS domain S-box; Region: sensory_box; TIGR00229 527021009352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021009353 putative active site [active] 527021009354 heme pocket [chemical binding]; other site 527021009355 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 527021009356 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 527021009357 metal binding site [ion binding]; metal-binding site 527021009358 active site 527021009359 I-site; other site 527021009360 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 527021009361 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 527021009362 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021009363 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021009364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021009365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021009366 beta-channel forming cytolysin; Region: hlyII; TIGR01002 527021009367 S-layer homology domain; Region: SLH; pfam00395 527021009368 S-layer homology domain; Region: SLH; pfam00395 527021009369 S-layer homology domain; Region: SLH; pfam00395 527021009370 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 527021009371 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 527021009372 active site 527021009373 metal binding site [ion binding]; metal-binding site 527021009374 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 527021009375 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 527021009376 TQXA domain; Region: TQXA_dom; TIGR03934 527021009377 Cna protein B-type domain; Region: Cna_B; pfam05738 527021009378 Cna protein B-type domain; Region: Cna_B; pfam05738 527021009379 Cna protein B-type domain; Region: Cna_B; pfam05738 527021009380 Cna protein B-type domain; Region: Cna_B; pfam05738 527021009381 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 527021009382 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 527021009383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021009384 dimer interface [polypeptide binding]; other site 527021009385 phosphorylation site [posttranslational modification] 527021009386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021009387 ATP binding site [chemical binding]; other site 527021009388 Mg2+ binding site [ion binding]; other site 527021009389 G-X-G motif; other site 527021009390 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 527021009391 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 527021009392 FOG: PKD repeat [General function prediction only]; Region: COG3291 527021009393 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 527021009394 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 527021009395 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 527021009396 MgtC family; Region: MgtC; pfam02308 527021009397 Predicted acetyltransferase [General function prediction only]; Region: COG3981 527021009398 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021009399 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 527021009400 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 527021009401 putative metal binding site [ion binding]; other site 527021009402 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 527021009403 active site 527021009404 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 527021009405 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 527021009406 substrate binding pocket [chemical binding]; other site 527021009407 membrane-bound complex binding site; other site 527021009408 hinge residues; other site 527021009409 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 527021009410 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 527021009411 Walker A/P-loop; other site 527021009412 ATP binding site [chemical binding]; other site 527021009413 Q-loop/lid; other site 527021009414 ABC transporter signature motif; other site 527021009415 Walker B; other site 527021009416 D-loop; other site 527021009417 H-loop/switch region; other site 527021009418 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 527021009419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021009420 dimer interface [polypeptide binding]; other site 527021009421 conserved gate region; other site 527021009422 putative PBP binding loops; other site 527021009423 ABC-ATPase subunit interface; other site 527021009424 VanW like protein; Region: VanW; pfam04294 527021009425 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 527021009426 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 527021009427 exonuclease; Provisional; Region: PRK06722 527021009428 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 527021009429 active site 527021009430 catalytic site [active] 527021009431 substrate binding site [chemical binding]; other site 527021009432 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 527021009433 DNA-binding site [nucleotide binding]; DNA binding site 527021009434 RNA-binding motif; other site 527021009435 flavodoxin; Provisional; Region: PRK06703 527021009436 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 527021009437 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 527021009438 nudix motif; other site 527021009439 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 527021009440 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 527021009441 trimer interface [polypeptide binding]; other site 527021009442 active site 527021009443 substrate binding site [chemical binding]; other site 527021009444 CoA binding site [chemical binding]; other site 527021009445 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009446 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009447 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009448 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009449 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009450 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009451 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009452 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009453 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009454 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009455 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009456 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009457 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021009458 short chain dehydrogenase; Provisional; Region: PRK06924 527021009459 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 527021009460 NADP binding site [chemical binding]; other site 527021009461 homodimer interface [polypeptide binding]; other site 527021009462 active site 527021009463 Predicted acetyltransferase [General function prediction only]; Region: COG3393 527021009464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021009465 argininosuccinate lyase; Provisional; Region: PRK06705 527021009466 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 527021009467 active sites [active] 527021009468 tetramer interface [polypeptide binding]; other site 527021009469 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021009470 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021009471 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 527021009472 active site 527021009473 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 527021009474 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 527021009475 Na binding site [ion binding]; other site 527021009476 Protein of unknown function (DUF997); Region: DUF997; pfam06196 527021009477 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 527021009478 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 527021009479 NAD(P) binding site [chemical binding]; other site 527021009480 catalytic residues [active] 527021009481 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 527021009482 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 527021009483 NAD(P) binding site [chemical binding]; other site 527021009484 homotetramer interface [polypeptide binding]; other site 527021009485 homodimer interface [polypeptide binding]; other site 527021009486 active site 527021009487 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 527021009488 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 527021009489 Divergent PAP2 family; Region: DUF212; pfam02681 527021009490 Predicted permeases [General function prediction only]; Region: RarD; COG2962 527021009491 EamA-like transporter family; Region: EamA; pfam00892 527021009492 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 527021009493 Domain of unknown function DUF59; Region: DUF59; pfam01883 527021009494 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 527021009495 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 527021009496 Walker A motif; other site 527021009497 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 527021009498 MoaE interaction surface [polypeptide binding]; other site 527021009499 MoeB interaction surface [polypeptide binding]; other site 527021009500 thiocarboxylated glycine; other site 527021009501 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 527021009502 MoaE homodimer interface [polypeptide binding]; other site 527021009503 MoaD interaction [polypeptide binding]; other site 527021009504 active site residues [active] 527021009505 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 527021009506 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 527021009507 dimer interface [polypeptide binding]; other site 527021009508 putative functional site; other site 527021009509 putative MPT binding site; other site 527021009510 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 527021009511 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 527021009512 ATP binding site [chemical binding]; other site 527021009513 substrate interface [chemical binding]; other site 527021009514 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 527021009515 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 527021009516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021009517 FeS/SAM binding site; other site 527021009518 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 527021009519 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 527021009520 Uncharacterized conserved protein [Function unknown]; Region: COG5609 527021009521 Uncharacterized conserved protein [Function unknown]; Region: COG2427 527021009522 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 527021009523 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 527021009524 catalytic loop [active] 527021009525 iron binding site [ion binding]; other site 527021009526 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 527021009527 4Fe-4S binding domain; Region: Fer4; pfam00037 527021009528 4Fe-4S binding domain; Region: Fer4; pfam00037 527021009529 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 527021009530 [4Fe-4S] binding site [ion binding]; other site 527021009531 molybdopterin cofactor binding site; other site 527021009532 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 527021009533 molybdopterin cofactor binding site; other site 527021009534 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021009535 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 527021009536 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 527021009537 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 527021009538 amino acid transporter; Region: 2A0306; TIGR00909 527021009539 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 527021009540 Tubulin like; Region: Tubulin_2; pfam13809 527021009541 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 527021009542 metal ion-dependent adhesion site (MIDAS); other site 527021009543 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021009544 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 527021009545 active site 527021009546 metal binding site [ion binding]; metal-binding site 527021009547 Methyltransferase domain; Region: Methyltransf_31; pfam13847 527021009548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021009549 S-adenosylmethionine binding site [chemical binding]; other site 527021009550 O-methyltransferase; Region: Methyltransf_2; pfam00891 527021009551 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021009552 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021009553 peptide binding site [polypeptide binding]; other site 527021009554 putative transposase OrfB; Reviewed; Region: PHA02517 527021009555 HTH-like domain; Region: HTH_21; pfam13276 527021009556 Integrase core domain; Region: rve; pfam00665 527021009557 Integrase core domain; Region: rve_2; pfam13333 527021009558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 527021009559 Helix-turn-helix domain; Region: HTH_28; pfam13518 527021009560 Helix-turn-helix domain; Region: HTH_28; pfam13518 527021009561 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021009562 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021009563 peptide binding site [polypeptide binding]; other site 527021009564 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 527021009565 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 527021009566 peptide binding site [polypeptide binding]; other site 527021009567 Transcriptional regulator [Transcription]; Region: LytR; COG1316 527021009568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021009569 DNA binding residues [nucleotide binding] 527021009570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021009571 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 527021009572 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021009573 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021009574 Walker A/P-loop; other site 527021009575 ATP binding site [chemical binding]; other site 527021009576 Q-loop/lid; other site 527021009577 ABC transporter signature motif; other site 527021009578 Walker B; other site 527021009579 D-loop; other site 527021009580 H-loop/switch region; other site 527021009581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021009582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021009583 Predicted transcriptional regulator [Transcription]; Region: COG2378 527021009584 HTH domain; Region: HTH_11; pfam08279 527021009585 WYL domain; Region: WYL; pfam13280 527021009586 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 527021009587 dimer interface [polypeptide binding]; other site 527021009588 putative oxidoreductase; Provisional; Region: PRK11579 527021009589 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 527021009590 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 527021009591 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 527021009592 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 527021009593 CAP-like domain; other site 527021009594 active site 527021009595 primary dimer interface [polypeptide binding]; other site 527021009596 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021009597 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021009598 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021009599 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021009600 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 527021009601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021009602 ATP binding site [chemical binding]; other site 527021009603 Mg2+ binding site [ion binding]; other site 527021009604 G-X-G motif; other site 527021009605 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 527021009606 anchoring element; other site 527021009607 dimer interface [polypeptide binding]; other site 527021009608 ATP binding site [chemical binding]; other site 527021009609 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 527021009610 active site 527021009611 putative metal-binding site [ion binding]; other site 527021009612 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 527021009613 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 527021009614 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 527021009615 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 527021009616 protein binding site [polypeptide binding]; other site 527021009617 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021009618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021009619 active site 527021009620 phosphorylation site [posttranslational modification] 527021009621 intermolecular recognition site; other site 527021009622 dimerization interface [polypeptide binding]; other site 527021009623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021009624 DNA binding site [nucleotide binding] 527021009625 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 527021009626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021009627 FeS/SAM binding site; other site 527021009628 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 527021009629 Class III ribonucleotide reductase; Region: RNR_III; cd01675 527021009630 effector binding site; other site 527021009631 active site 527021009632 Zn binding site [ion binding]; other site 527021009633 glycine loop; other site 527021009634 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 527021009635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 527021009636 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 527021009637 active site 527021009638 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 527021009639 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021009640 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021009641 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 527021009642 active site 527021009643 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 527021009644 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 527021009645 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 527021009646 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 527021009647 active site 527021009648 catalytic site [active] 527021009649 substrate binding site [chemical binding]; other site 527021009650 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 527021009651 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 527021009652 catalytic residues [active] 527021009653 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 527021009654 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021009655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021009656 Walker A/P-loop; other site 527021009657 ATP binding site [chemical binding]; other site 527021009658 Q-loop/lid; other site 527021009659 ABC transporter signature motif; other site 527021009660 Walker B; other site 527021009661 D-loop; other site 527021009662 H-loop/switch region; other site 527021009663 aconitate hydratase; Validated; Region: PRK09277 527021009664 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 527021009665 substrate binding site [chemical binding]; other site 527021009666 ligand binding site [chemical binding]; other site 527021009667 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 527021009668 substrate binding site [chemical binding]; other site 527021009669 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 527021009670 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 527021009671 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 527021009672 NodB motif; other site 527021009673 active site 527021009674 catalytic site [active] 527021009675 metal binding site [ion binding]; metal-binding site 527021009676 Small acid-soluble spore protein P family; Region: SspP; cl12105 527021009677 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 527021009678 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 527021009679 putative dimer interface [polypeptide binding]; other site 527021009680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021009681 putative substrate translocation pore; other site 527021009682 putative transporter; Provisional; Region: PRK10054 527021009683 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 527021009684 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 527021009685 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 527021009686 nudix motif; other site 527021009687 SAP domain; Region: SAP; cl02640 527021009688 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 527021009689 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 527021009690 dimer interface [polypeptide binding]; other site 527021009691 active site 527021009692 acyl-CoA synthetase; Validated; Region: PRK07638 527021009693 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 527021009694 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 527021009695 acyl-activating enzyme (AAE) consensus motif; other site 527021009696 acyl-activating enzyme (AAE) consensus motif; other site 527021009697 AMP binding site [chemical binding]; other site 527021009698 active site 527021009699 CoA binding site [chemical binding]; other site 527021009700 BioY family; Region: BioY; pfam02632 527021009701 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 527021009702 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 527021009703 dimer interface [polypeptide binding]; other site 527021009704 acyl-activating enzyme (AAE) consensus motif; other site 527021009705 putative active site [active] 527021009706 AMP binding site [chemical binding]; other site 527021009707 putative CoA binding site [chemical binding]; other site 527021009708 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021009709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021009710 non-specific DNA binding site [nucleotide binding]; other site 527021009711 salt bridge; other site 527021009712 sequence-specific DNA binding site [nucleotide binding]; other site 527021009713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021009714 Coenzyme A binding pocket [chemical binding]; other site 527021009715 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 527021009716 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 527021009717 amidase catalytic site [active] 527021009718 Zn binding residues [ion binding]; other site 527021009719 substrate binding site [chemical binding]; other site 527021009720 active site 527021009721 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 527021009722 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021009723 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021009724 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021009725 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021009726 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 527021009727 dimer interface [polypeptide binding]; other site 527021009728 putative metal binding site [ion binding]; other site 527021009729 PAS domain S-box; Region: sensory_box; TIGR00229 527021009730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021009731 putative active site [active] 527021009732 heme pocket [chemical binding]; other site 527021009733 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 527021009734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021009735 putative active site [active] 527021009736 heme pocket [chemical binding]; other site 527021009737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021009738 dimer interface [polypeptide binding]; other site 527021009739 phosphorylation site [posttranslational modification] 527021009740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021009741 ATP binding site [chemical binding]; other site 527021009742 Mg2+ binding site [ion binding]; other site 527021009743 G-X-G motif; other site 527021009744 Predicted esterase [General function prediction only]; Region: COG0400 527021009745 putative hydrolase; Provisional; Region: PRK11460 527021009746 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 527021009747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021009748 Zn binding site [ion binding]; other site 527021009749 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 527021009750 Zn binding site [ion binding]; other site 527021009751 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 527021009752 Na binding site [ion binding]; other site 527021009753 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 527021009754 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 527021009755 active site 527021009756 FMN binding site [chemical binding]; other site 527021009757 substrate binding site [chemical binding]; other site 527021009758 3Fe-4S cluster binding site [ion binding]; other site 527021009759 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 527021009760 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 527021009761 FMN binding site [chemical binding]; other site 527021009762 active site 527021009763 substrate binding site [chemical binding]; other site 527021009764 catalytic residue [active] 527021009765 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 527021009766 agmatinase; Region: agmatinase; TIGR01230 527021009767 Agmatinase-like family; Region: Agmatinase-like; cd09990 527021009768 active site 527021009769 oligomer interface [polypeptide binding]; other site 527021009770 Mn binding site [ion binding]; other site 527021009771 imidazolonepropionase; Validated; Region: PRK09356 527021009772 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 527021009773 active site 527021009774 urocanate hydratase; Provisional; Region: PRK05414 527021009775 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 527021009776 active sites [active] 527021009777 tetramer interface [polypeptide binding]; other site 527021009778 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 527021009779 hexamer interface [polypeptide binding]; other site 527021009780 RNA binding site [nucleotide binding]; other site 527021009781 Histidine-zinc binding site [chemical binding]; other site 527021009782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021009783 S-adenosylmethionine binding site [chemical binding]; other site 527021009784 DJ-1 family protein; Region: not_thiJ; TIGR01383 527021009785 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 527021009786 conserved cys residue [active] 527021009787 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 527021009788 AAA domain; Region: AAA_28; pfam13521 527021009789 active site 527021009790 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 527021009791 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 527021009792 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 527021009793 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 527021009794 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 527021009795 EamA-like transporter family; Region: EamA; pfam00892 527021009796 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 527021009797 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 527021009798 metal binding site [ion binding]; metal-binding site 527021009799 dimer interface [polypeptide binding]; other site 527021009800 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 527021009801 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 527021009802 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021009803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021009804 Walker A/P-loop; other site 527021009805 ATP binding site [chemical binding]; other site 527021009806 Q-loop/lid; other site 527021009807 ABC transporter signature motif; other site 527021009808 Walker B; other site 527021009809 D-loop; other site 527021009810 H-loop/switch region; other site 527021009811 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 527021009812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021009813 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 527021009814 putative dimerization interface [polypeptide binding]; other site 527021009815 putative substrate binding pocket [chemical binding]; other site 527021009816 holin-like protein; Validated; Region: PRK01658 527021009817 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 527021009818 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 527021009819 nudix motif; other site 527021009820 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 527021009821 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 527021009822 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021009823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021009824 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021009825 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 527021009826 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 527021009827 active site 527021009828 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021009829 Bacterial SH3 domain; Region: SH3_3; cl17532 527021009830 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 527021009831 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021009832 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 527021009833 Walker A/P-loop; other site 527021009834 ATP binding site [chemical binding]; other site 527021009835 Q-loop/lid; other site 527021009836 ABC transporter signature motif; other site 527021009837 Walker B; other site 527021009838 D-loop; other site 527021009839 H-loop/switch region; other site 527021009840 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021009841 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 527021009842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021009843 Walker A/P-loop; other site 527021009844 ATP binding site [chemical binding]; other site 527021009845 Q-loop/lid; other site 527021009846 ABC transporter signature motif; other site 527021009847 Walker B; other site 527021009848 D-loop; other site 527021009849 H-loop/switch region; other site 527021009850 hypothetical protein; Provisional; Region: PRK01844 527021009851 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 527021009852 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 527021009853 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 527021009854 TPP-binding site [chemical binding]; other site 527021009855 dimer interface [polypeptide binding]; other site 527021009856 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 527021009857 PYR/PP interface [polypeptide binding]; other site 527021009858 dimer interface [polypeptide binding]; other site 527021009859 TPP binding site [chemical binding]; other site 527021009860 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 527021009861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021009862 dimer interface [polypeptide binding]; other site 527021009863 conserved gate region; other site 527021009864 ABC-ATPase subunit interface; other site 527021009865 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 527021009866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021009867 dimer interface [polypeptide binding]; other site 527021009868 conserved gate region; other site 527021009869 ABC-ATPase subunit interface; other site 527021009870 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 527021009871 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 527021009872 Walker A/P-loop; other site 527021009873 ATP binding site [chemical binding]; other site 527021009874 Q-loop/lid; other site 527021009875 ABC transporter signature motif; other site 527021009876 Walker B; other site 527021009877 D-loop; other site 527021009878 H-loop/switch region; other site 527021009879 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 527021009880 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 527021009881 membrane-bound complex binding site; other site 527021009882 hinge residues; other site 527021009883 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 527021009884 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 527021009885 active site 527021009886 metal binding site [ion binding]; metal-binding site 527021009887 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 527021009888 hypothetical protein; Provisional; Region: PRK01546 527021009889 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 527021009890 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 527021009891 catalytic residues [active] 527021009892 catalytic nucleophile [active] 527021009893 LexA repressor; Validated; Region: PRK00215 527021009894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021009895 putative DNA binding site [nucleotide binding]; other site 527021009896 putative Zn2+ binding site [ion binding]; other site 527021009897 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 527021009898 Catalytic site [active] 527021009899 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 527021009900 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 527021009901 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 527021009902 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021009903 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 527021009904 glutamine synthetase, type I; Region: GlnA; TIGR00653 527021009905 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 527021009906 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 527021009907 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 527021009908 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021009909 DNA binding residues [nucleotide binding] 527021009910 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 527021009911 Aluminium resistance protein; Region: Alum_res; pfam06838 527021009912 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 527021009913 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 527021009914 HflX GTPase family; Region: HflX; cd01878 527021009915 G1 box; other site 527021009916 GTP/Mg2+ binding site [chemical binding]; other site 527021009917 Switch I region; other site 527021009918 G2 box; other site 527021009919 G3 box; other site 527021009920 Switch II region; other site 527021009921 G4 box; other site 527021009922 G5 box; other site 527021009923 Predicted membrane protein [Function unknown]; Region: COG2860 527021009924 UPF0126 domain; Region: UPF0126; pfam03458 527021009925 UPF0126 domain; Region: UPF0126; pfam03458 527021009926 stage V sporulation protein K; Region: spore_V_K; TIGR02881 527021009927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021009928 Walker A motif; other site 527021009929 ATP binding site [chemical binding]; other site 527021009930 Walker B motif; other site 527021009931 arginine finger; other site 527021009932 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 527021009933 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 527021009934 active site 527021009935 catalytic residues [active] 527021009936 DNA binding site [nucleotide binding] 527021009937 Int/Topo IB signature motif; other site 527021009938 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 527021009939 putative transposase OrfB; Reviewed; Region: PHA02517 527021009940 HTH-like domain; Region: HTH_21; pfam13276 527021009941 Integrase core domain; Region: rve; pfam00665 527021009942 Integrase core domain; Region: rve_2; pfam13333 527021009943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 527021009944 Helix-turn-helix domain; Region: HTH_28; pfam13518 527021009945 Helix-turn-helix domain; Region: HTH_28; pfam13518 527021009946 bacterial Hfq-like; Region: Hfq; cd01716 527021009947 hexamer interface [polypeptide binding]; other site 527021009948 Sm1 motif; other site 527021009949 RNA binding site [nucleotide binding]; other site 527021009950 Sm2 motif; other site 527021009951 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 527021009952 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 527021009953 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021009954 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021009955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 527021009956 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 527021009957 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 527021009958 active site 527021009959 phosphorylation site [posttranslational modification] 527021009960 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 527021009961 active site 527021009962 P-loop; other site 527021009963 phosphorylation site [posttranslational modification] 527021009964 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 527021009965 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 527021009966 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 527021009967 putative substrate binding site [chemical binding]; other site 527021009968 putative ATP binding site [chemical binding]; other site 527021009969 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 527021009970 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 527021009971 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 527021009972 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 527021009973 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 527021009974 dimer interface [polypeptide binding]; other site 527021009975 active site 527021009976 metal binding site [ion binding]; metal-binding site 527021009977 Predicted membrane protein [Function unknown]; Region: COG2322 527021009978 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 527021009979 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 527021009980 Glyco_18 domain; Region: Glyco_18; smart00636 527021009981 putative active site [active] 527021009982 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 527021009983 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021009984 putative active site [active] 527021009985 putative metal binding site [ion binding]; other site 527021009986 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 527021009987 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 527021009988 IHF dimer interface [polypeptide binding]; other site 527021009989 IHF - DNA interface [nucleotide binding]; other site 527021009990 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021009991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021009992 Coenzyme A binding pocket [chemical binding]; other site 527021009993 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 527021009994 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 527021009995 metal-binding site [ion binding] 527021009996 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 527021009997 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 527021009998 metal-binding site [ion binding] 527021009999 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 527021010000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021010001 motif II; other site 527021010002 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 527021010003 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 527021010004 metal-binding site [ion binding] 527021010005 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 527021010006 putative homodimer interface [polypeptide binding]; other site 527021010007 putative homotetramer interface [polypeptide binding]; other site 527021010008 allosteric switch controlling residues; other site 527021010009 putative metal binding site [ion binding]; other site 527021010010 putative homodimer-homodimer interface [polypeptide binding]; other site 527021010011 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021010012 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021010013 DNA binding residues [nucleotide binding] 527021010014 dimerization interface [polypeptide binding]; other site 527021010015 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021010016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021010017 S-adenosylmethionine binding site [chemical binding]; other site 527021010018 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 527021010019 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 527021010020 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 527021010021 Walker A/P-loop; other site 527021010022 ATP binding site [chemical binding]; other site 527021010023 Q-loop/lid; other site 527021010024 ABC transporter signature motif; other site 527021010025 Walker B; other site 527021010026 D-loop; other site 527021010027 H-loop/switch region; other site 527021010028 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 527021010029 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021010030 ABC-ATPase subunit interface; other site 527021010031 dimer interface [polypeptide binding]; other site 527021010032 putative PBP binding regions; other site 527021010033 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 527021010034 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021010035 ABC-ATPase subunit interface; other site 527021010036 dimer interface [polypeptide binding]; other site 527021010037 putative PBP binding regions; other site 527021010038 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 527021010039 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 527021010040 putative ligand binding residues [chemical binding]; other site 527021010041 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 527021010042 active site 527021010043 putative catalytic site [active] 527021010044 DNA binding site [nucleotide binding] 527021010045 putative phosphate binding site [ion binding]; other site 527021010046 metal binding site A [ion binding]; metal-binding site 527021010047 AP binding site [nucleotide binding]; other site 527021010048 metal binding site B [ion binding]; metal-binding site 527021010049 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 527021010050 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 527021010051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021010052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021010053 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 527021010054 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 527021010055 DNA binding site [nucleotide binding] 527021010056 active site 527021010057 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 527021010058 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 527021010059 endonuclease III; Region: ENDO3c; smart00478 527021010060 minor groove reading motif; other site 527021010061 helix-hairpin-helix signature motif; other site 527021010062 substrate binding pocket [chemical binding]; other site 527021010063 active site 527021010064 peptidase T; Region: peptidase-T; TIGR01882 527021010065 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 527021010066 metal binding site [ion binding]; metal-binding site 527021010067 dimer interface [polypeptide binding]; other site 527021010068 Predicted membrane protein [Function unknown]; Region: COG2364 527021010069 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021010070 hypothetical protein; Provisional; Region: PRK06764 527021010071 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 527021010072 catalytic core [active] 527021010073 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021010074 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 527021010075 PAS domain S-box; Region: sensory_box; TIGR00229 527021010076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021010077 putative active site [active] 527021010078 heme pocket [chemical binding]; other site 527021010079 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 527021010080 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 527021010081 metal binding site [ion binding]; metal-binding site 527021010082 active site 527021010083 I-site; other site 527021010084 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 527021010085 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 527021010086 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 527021010087 active site 527021010088 homodimer interface [polypeptide binding]; other site 527021010089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021010090 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 527021010091 NAD(P) binding site [chemical binding]; other site 527021010092 active site 527021010093 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 527021010094 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 527021010095 NAD(P) binding site [chemical binding]; other site 527021010096 homodimer interface [polypeptide binding]; other site 527021010097 substrate binding site [chemical binding]; other site 527021010098 active site 527021010099 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 527021010100 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 527021010101 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 527021010102 holin-like protein; Validated; Region: PRK01658 527021010103 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 527021010104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021010105 DNA-binding site [nucleotide binding]; DNA binding site 527021010106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021010107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021010108 homodimer interface [polypeptide binding]; other site 527021010109 catalytic residue [active] 527021010110 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 527021010111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021010112 DNA-binding site [nucleotide binding]; DNA binding site 527021010113 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 527021010114 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 527021010115 beta-galactosidase; Region: BGL; TIGR03356 527021010116 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 527021010117 active site 527021010118 catalytic site [active] 527021010119 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 527021010120 putative active site [active] 527021010121 putative catalytic triad [active] 527021010122 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 527021010123 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021010124 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 527021010125 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021010126 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 527021010127 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 527021010128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 527021010129 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 527021010130 Sulfatase; Region: Sulfatase; pfam00884 527021010131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021010132 binding surface 527021010133 TPR motif; other site 527021010134 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 527021010135 G1 box; other site 527021010136 GTP/Mg2+ binding site [chemical binding]; other site 527021010137 Switch I region; other site 527021010138 G3 box; other site 527021010139 Switch II region; other site 527021010140 G4 box; other site 527021010141 G5 box; other site 527021010142 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 527021010143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021010144 ATP binding site [chemical binding]; other site 527021010145 Mg2+ binding site [ion binding]; other site 527021010146 G-X-G motif; other site 527021010147 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 527021010148 ATP binding site [chemical binding]; other site 527021010149 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 527021010150 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 527021010151 MutS domain I; Region: MutS_I; pfam01624 527021010152 MutS domain II; Region: MutS_II; pfam05188 527021010153 MutS domain III; Region: MutS_III; pfam05192 527021010154 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 527021010155 Walker A/P-loop; other site 527021010156 ATP binding site [chemical binding]; other site 527021010157 Q-loop/lid; other site 527021010158 ABC transporter signature motif; other site 527021010159 Walker B; other site 527021010160 D-loop; other site 527021010161 H-loop/switch region; other site 527021010162 Outer spore coat protein E (CotE); Region: CotE; pfam10628 527021010163 Predicted membrane protein [Function unknown]; Region: COG4550 527021010164 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 527021010165 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 527021010166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021010167 FeS/SAM binding site; other site 527021010168 TRAM domain; Region: TRAM; pfam01938 527021010169 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 527021010170 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 527021010171 TPP-binding site [chemical binding]; other site 527021010172 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 527021010173 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 527021010174 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 527021010175 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 527021010176 dimer interface [polypeptide binding]; other site 527021010177 PYR/PP interface [polypeptide binding]; other site 527021010178 TPP binding site [chemical binding]; other site 527021010179 substrate binding site [chemical binding]; other site 527021010180 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 527021010181 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 527021010182 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 527021010183 active site 527021010184 dimer interface [polypeptide binding]; other site 527021010185 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 527021010186 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 527021010187 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021010188 putative active site [active] 527021010189 metal binding site [ion binding]; metal-binding site 527021010190 homodimer binding site [polypeptide binding]; other site 527021010191 phosphodiesterase; Provisional; Region: PRK12704 527021010192 Uncharacterized conserved protein [Function unknown]; Region: COG3334 527021010193 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021010194 Zn2+ binding site [ion binding]; other site 527021010195 Mg2+ binding site [ion binding]; other site 527021010196 recombinase A; Provisional; Region: recA; PRK09354 527021010197 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 527021010198 hexamer interface [polypeptide binding]; other site 527021010199 Walker A motif; other site 527021010200 ATP binding site [chemical binding]; other site 527021010201 Walker B motif; other site 527021010202 competence damage-inducible protein A; Provisional; Region: PRK00549 527021010203 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 527021010204 putative MPT binding site; other site 527021010205 Competence-damaged protein; Region: CinA; pfam02464 527021010206 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 527021010207 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 527021010208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021010209 non-specific DNA binding site [nucleotide binding]; other site 527021010210 salt bridge; other site 527021010211 sequence-specific DNA binding site [nucleotide binding]; other site 527021010212 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 527021010213 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 527021010214 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 527021010215 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 527021010216 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 527021010217 classical (c) SDRs; Region: SDR_c; cd05233 527021010218 NAD(P) binding site [chemical binding]; other site 527021010219 active site 527021010220 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 527021010221 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 527021010222 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 527021010223 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 527021010224 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 527021010225 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 527021010226 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 527021010227 TM-ABC transporter signature motif; other site 527021010228 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 527021010229 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 527021010230 TM-ABC transporter signature motif; other site 527021010231 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 527021010232 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 527021010233 Walker A/P-loop; other site 527021010234 ATP binding site [chemical binding]; other site 527021010235 Q-loop/lid; other site 527021010236 ABC transporter signature motif; other site 527021010237 Walker B; other site 527021010238 D-loop; other site 527021010239 H-loop/switch region; other site 527021010240 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 527021010241 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 527021010242 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 527021010243 ligand binding site [chemical binding]; other site 527021010244 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 527021010245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021010246 DNA-binding site [nucleotide binding]; DNA binding site 527021010247 UTRA domain; Region: UTRA; pfam07702 527021010248 Tetraspanin family; Region: Tetraspannin; pfam00335 527021010249 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 527021010250 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 527021010251 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 527021010252 YlzJ-like protein; Region: YlzJ; pfam14035 527021010253 Clp protease; Region: CLP_protease; pfam00574 527021010254 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 527021010255 active site 527021010256 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 527021010257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021010258 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 527021010259 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 527021010260 dihydrodipicolinate synthase; Region: dapA; TIGR00674 527021010261 dimer interface [polypeptide binding]; other site 527021010262 active site 527021010263 catalytic residue [active] 527021010264 aspartate kinase I; Reviewed; Region: PRK08210 527021010265 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 527021010266 nucleotide binding site [chemical binding]; other site 527021010267 substrate binding site [chemical binding]; other site 527021010268 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 527021010269 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 527021010270 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 527021010271 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 527021010272 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 527021010273 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 527021010274 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 527021010275 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 527021010276 active site 527021010277 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 527021010278 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 527021010279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021010280 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021010281 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021010282 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 527021010283 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021010284 Phage tail protein; Region: Sipho_tail; pfam05709 527021010285 Phage tail protein; Region: Sipho_tail; cl17486 527021010286 Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730 527021010287 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 527021010288 Phage-related protein [Function unknown]; Region: COG5412 527021010289 membrane protein P6; Region: PHA01399 527021010290 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 527021010291 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 527021010292 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 527021010293 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 527021010294 oligomer interface [polypeptide binding]; other site 527021010295 active site residues [active] 527021010296 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 527021010297 Phage-related protein [Function unknown]; Region: COG4695; cl01923 527021010298 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 527021010299 Phage terminase, small subunit; Region: Terminase_4; cl01525 527021010300 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 527021010301 HNH endonuclease; Region: HNH; pfam01844 527021010302 active site 527021010303 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 527021010304 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 527021010305 active site 527021010306 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 527021010307 Int/Topo IB signature motif; other site 527021010308 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 527021010309 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 527021010310 replicative DNA helicase; Provisional; Region: PRK06749 527021010311 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 527021010312 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 527021010313 Walker A motif; other site 527021010314 ATP binding site [chemical binding]; other site 527021010315 Walker B motif; other site 527021010316 DNA binding loops [nucleotide binding] 527021010317 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 527021010318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021010319 sequence-specific DNA binding site [nucleotide binding]; other site 527021010320 salt bridge; other site 527021010321 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021010322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021010323 non-specific DNA binding site [nucleotide binding]; other site 527021010324 salt bridge; other site 527021010325 sequence-specific DNA binding site [nucleotide binding]; other site 527021010326 Domain of unknown function (DUF955); Region: DUF955; cl01076 527021010327 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 527021010328 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 527021010329 catalytic residues [active] 527021010330 catalytic nucleophile [active] 527021010331 Recombinase; Region: Recombinase; pfam07508 527021010332 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 527021010333 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 527021010334 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 527021010335 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 527021010336 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 527021010337 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 527021010338 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 527021010339 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 527021010340 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 527021010341 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 527021010342 NodB motif; other site 527021010343 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 527021010344 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 527021010345 RNase E interface [polypeptide binding]; other site 527021010346 trimer interface [polypeptide binding]; other site 527021010347 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 527021010348 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 527021010349 RNase E interface [polypeptide binding]; other site 527021010350 trimer interface [polypeptide binding]; other site 527021010351 active site 527021010352 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 527021010353 putative nucleic acid binding region [nucleotide binding]; other site 527021010354 G-X-X-G motif; other site 527021010355 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 527021010356 RNA binding site [nucleotide binding]; other site 527021010357 domain interface; other site 527021010358 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 527021010359 16S/18S rRNA binding site [nucleotide binding]; other site 527021010360 S13e-L30e interaction site [polypeptide binding]; other site 527021010361 25S rRNA binding site [nucleotide binding]; other site 527021010362 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 527021010363 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 527021010364 active site 527021010365 Riboflavin kinase; Region: Flavokinase; pfam01687 527021010366 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 527021010367 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 527021010368 RNA binding site [nucleotide binding]; other site 527021010369 active site 527021010370 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 527021010371 Protein of unknown function (DUF503); Region: DUF503; pfam04456 527021010372 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 527021010373 translation initiation factor IF-2; Region: IF-2; TIGR00487 527021010374 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 527021010375 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 527021010376 G1 box; other site 527021010377 putative GEF interaction site [polypeptide binding]; other site 527021010378 GTP/Mg2+ binding site [chemical binding]; other site 527021010379 Switch I region; other site 527021010380 G2 box; other site 527021010381 G3 box; other site 527021010382 Switch II region; other site 527021010383 G4 box; other site 527021010384 G5 box; other site 527021010385 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 527021010386 Translation-initiation factor 2; Region: IF-2; pfam11987 527021010387 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 527021010388 hypothetical protein; Provisional; Region: PRK07714 527021010389 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 527021010390 putative RNA binding cleft [nucleotide binding]; other site 527021010391 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 527021010392 NusA N-terminal domain; Region: NusA_N; pfam08529 527021010393 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 527021010394 RNA binding site [nucleotide binding]; other site 527021010395 homodimer interface [polypeptide binding]; other site 527021010396 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 527021010397 G-X-X-G motif; other site 527021010398 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 527021010399 G-X-X-G motif; other site 527021010400 ribosome maturation protein RimP; Reviewed; Region: PRK00092 527021010401 Sm and related proteins; Region: Sm_like; cl00259 527021010402 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 527021010403 putative oligomer interface [polypeptide binding]; other site 527021010404 putative RNA binding site [nucleotide binding]; other site 527021010405 DNA polymerase III PolC; Validated; Region: polC; PRK00448 527021010406 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 527021010407 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 527021010408 generic binding surface II; other site 527021010409 generic binding surface I; other site 527021010410 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 527021010411 active site 527021010412 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 527021010413 active site 527021010414 catalytic site [active] 527021010415 substrate binding site [chemical binding]; other site 527021010416 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 527021010417 prolyl-tRNA synthetase; Provisional; Region: PRK09194 527021010418 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 527021010419 dimer interface [polypeptide binding]; other site 527021010420 motif 1; other site 527021010421 active site 527021010422 motif 2; other site 527021010423 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 527021010424 putative deacylase active site [active] 527021010425 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 527021010426 active site 527021010427 motif 3; other site 527021010428 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 527021010429 anticodon binding site; other site 527021010430 RIP metalloprotease RseP; Region: TIGR00054 527021010431 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 527021010432 active site 527021010433 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 527021010434 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 527021010435 protein binding site [polypeptide binding]; other site 527021010436 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 527021010437 putative substrate binding region [chemical binding]; other site 527021010438 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 527021010439 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 527021010440 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 527021010441 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 527021010442 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 527021010443 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 527021010444 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 527021010445 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 527021010446 catalytic residue [active] 527021010447 putative FPP diphosphate binding site; other site 527021010448 putative FPP binding hydrophobic cleft; other site 527021010449 dimer interface [polypeptide binding]; other site 527021010450 putative IPP diphosphate binding site; other site 527021010451 ribosome recycling factor; Reviewed; Region: frr; PRK00083 527021010452 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 527021010453 hinge region; other site 527021010454 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 527021010455 putative nucleotide binding site [chemical binding]; other site 527021010456 uridine monophosphate binding site [chemical binding]; other site 527021010457 homohexameric interface [polypeptide binding]; other site 527021010458 elongation factor Ts; Provisional; Region: tsf; PRK09377 527021010459 UBA/TS-N domain; Region: UBA; pfam00627 527021010460 Elongation factor TS; Region: EF_TS; pfam00889 527021010461 Elongation factor TS; Region: EF_TS; pfam00889 527021010462 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 527021010463 rRNA interaction site [nucleotide binding]; other site 527021010464 S8 interaction site; other site 527021010465 putative laminin-1 binding site; other site 527021010466 transcriptional repressor CodY; Validated; Region: PRK04158 527021010467 CodY GAF-like domain; Region: CodY; pfam06018 527021010468 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 527021010469 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 527021010470 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 527021010471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021010472 Walker A motif; other site 527021010473 ATP binding site [chemical binding]; other site 527021010474 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 527021010475 active site 527021010476 HslU subunit interaction site [polypeptide binding]; other site 527021010477 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 527021010478 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 527021010479 active site 527021010480 Int/Topo IB signature motif; other site 527021010481 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 527021010482 Glucose inhibited division protein A; Region: GIDA; pfam01134 527021010483 DNA topoisomerase I; Validated; Region: PRK05582 527021010484 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 527021010485 active site 527021010486 interdomain interaction site; other site 527021010487 putative metal-binding site [ion binding]; other site 527021010488 nucleotide binding site [chemical binding]; other site 527021010489 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 527021010490 domain I; other site 527021010491 DNA binding groove [nucleotide binding] 527021010492 phosphate binding site [ion binding]; other site 527021010493 domain II; other site 527021010494 domain III; other site 527021010495 nucleotide binding site [chemical binding]; other site 527021010496 catalytic site [active] 527021010497 domain IV; other site 527021010498 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 527021010499 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 527021010500 DNA protecting protein DprA; Region: dprA; TIGR00732 527021010501 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 527021010502 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 527021010503 CoA binding domain; Region: CoA_binding; smart00881 527021010504 CoA-ligase; Region: Ligase_CoA; pfam00549 527021010505 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 527021010506 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 527021010507 CoA-ligase; Region: Ligase_CoA; pfam00549 527021010508 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 527021010509 RNA/DNA hybrid binding site [nucleotide binding]; other site 527021010510 active site 527021010511 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 527021010512 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 527021010513 GTP/Mg2+ binding site [chemical binding]; other site 527021010514 G4 box; other site 527021010515 G5 box; other site 527021010516 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 527021010517 G1 box; other site 527021010518 G1 box; other site 527021010519 GTP/Mg2+ binding site [chemical binding]; other site 527021010520 Switch I region; other site 527021010521 G2 box; other site 527021010522 G2 box; other site 527021010523 G3 box; other site 527021010524 G3 box; other site 527021010525 Switch II region; other site 527021010526 Switch II region; other site 527021010527 G4 box; other site 527021010528 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 527021010529 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021010530 Catalytic site [active] 527021010531 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 527021010532 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 527021010533 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 527021010534 RimM N-terminal domain; Region: RimM; pfam01782 527021010535 PRC-barrel domain; Region: PRC; pfam05239 527021010536 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 527021010537 KH domain; Region: KH_4; pfam13083 527021010538 G-X-X-G motif; other site 527021010539 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 527021010540 signal recognition particle protein; Provisional; Region: PRK10867 527021010541 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 527021010542 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 527021010543 P loop; other site 527021010544 GTP binding site [chemical binding]; other site 527021010545 Signal peptide binding domain; Region: SRP_SPB; pfam02978 527021010546 putative DNA-binding protein; Validated; Region: PRK00118 527021010547 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 527021010548 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 527021010549 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 527021010550 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 527021010551 P loop; other site 527021010552 GTP binding site [chemical binding]; other site 527021010553 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 527021010554 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 527021010555 Walker A/P-loop; other site 527021010556 ATP binding site [chemical binding]; other site 527021010557 Q-loop/lid; other site 527021010558 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 527021010559 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 527021010560 ABC transporter signature motif; other site 527021010561 Walker B; other site 527021010562 D-loop; other site 527021010563 H-loop/switch region; other site 527021010564 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 527021010565 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 527021010566 dimerization interface [polypeptide binding]; other site 527021010567 active site 527021010568 metal binding site [ion binding]; metal-binding site 527021010569 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 527021010570 dsRNA binding site [nucleotide binding]; other site 527021010571 acyl carrier protein; Provisional; Region: acpP; PRK00982 527021010572 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 527021010573 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 527021010574 NAD(P) binding site [chemical binding]; other site 527021010575 homotetramer interface [polypeptide binding]; other site 527021010576 homodimer interface [polypeptide binding]; other site 527021010577 active site 527021010578 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 527021010579 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 527021010580 putative phosphate acyltransferase; Provisional; Region: PRK05331 527021010581 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 527021010582 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 527021010583 active site 2 [active] 527021010584 active site 1 [active] 527021010585 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 527021010586 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 527021010587 generic binding surface II; other site 527021010588 ssDNA binding site; other site 527021010589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021010590 ATP binding site [chemical binding]; other site 527021010591 putative Mg++ binding site [ion binding]; other site 527021010592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021010593 nucleotide binding region [chemical binding]; other site 527021010594 ATP-binding site [chemical binding]; other site 527021010595 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 527021010596 DAK2 domain; Region: Dak2; pfam02734 527021010597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 527021010598 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 527021010599 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 527021010600 Thiamine pyrophosphokinase; Region: TPK; cd07995 527021010601 active site 527021010602 dimerization interface [polypeptide binding]; other site 527021010603 thiamine binding site [chemical binding]; other site 527021010604 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 527021010605 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 527021010606 substrate binding site [chemical binding]; other site 527021010607 hexamer interface [polypeptide binding]; other site 527021010608 metal binding site [ion binding]; metal-binding site 527021010609 GTPase RsgA; Reviewed; Region: PRK00098 527021010610 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 527021010611 RNA binding site [nucleotide binding]; other site 527021010612 homodimer interface [polypeptide binding]; other site 527021010613 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 527021010614 GTPase/Zn-binding domain interface [polypeptide binding]; other site 527021010615 GTP/Mg2+ binding site [chemical binding]; other site 527021010616 G4 box; other site 527021010617 G5 box; other site 527021010618 G1 box; other site 527021010619 Switch I region; other site 527021010620 G2 box; other site 527021010621 G3 box; other site 527021010622 Switch II region; other site 527021010623 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 527021010624 Catalytic domain of Protein Kinases; Region: PKc; cd00180 527021010625 active site 527021010626 ATP binding site [chemical binding]; other site 527021010627 substrate binding site [chemical binding]; other site 527021010628 activation loop (A-loop); other site 527021010629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 527021010630 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 527021010631 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 527021010632 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 527021010633 Protein phosphatase 2C; Region: PP2C; pfam00481 527021010634 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 527021010635 active site 527021010636 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 527021010637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021010638 FeS/SAM binding site; other site 527021010639 16S rRNA methyltransferase B; Provisional; Region: PRK14902 527021010640 NusB family; Region: NusB; pfam01029 527021010641 putative RNA binding site [nucleotide binding]; other site 527021010642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021010643 S-adenosylmethionine binding site [chemical binding]; other site 527021010644 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 527021010645 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 527021010646 putative active site [active] 527021010647 substrate binding site [chemical binding]; other site 527021010648 putative cosubstrate binding site; other site 527021010649 catalytic site [active] 527021010650 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 527021010651 substrate binding site [chemical binding]; other site 527021010652 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 527021010653 active site 527021010654 catalytic residues [active] 527021010655 metal binding site [ion binding]; metal-binding site 527021010656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021010657 primosomal protein N' Region: priA; TIGR00595 527021010658 ATP binding site [chemical binding]; other site 527021010659 putative Mg++ binding site [ion binding]; other site 527021010660 helicase superfamily c-terminal domain; Region: HELICc; smart00490 527021010661 nucleotide binding region [chemical binding]; other site 527021010662 ATP-binding site [chemical binding]; other site 527021010663 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 527021010664 Flavoprotein; Region: Flavoprotein; pfam02441 527021010665 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 527021010666 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 527021010667 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 527021010668 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 527021010669 catalytic site [active] 527021010670 G-X2-G-X-G-K; other site 527021010671 hypothetical protein; Provisional; Region: PRK04323 527021010672 hypothetical protein; Provisional; Region: PRK11820 527021010673 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 527021010674 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 527021010675 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 527021010676 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 527021010677 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 527021010678 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 527021010679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021010680 motif II; other site 527021010681 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 527021010682 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 527021010683 Domain of unknown function (DUF814); Region: DUF814; pfam05670 527021010684 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 527021010685 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 527021010686 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 527021010687 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 527021010688 active site 527021010689 DinB superfamily; Region: DinB_2; pfam12867 527021010690 YoqO-like protein; Region: YoqO; pfam14037 527021010691 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 527021010692 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 527021010693 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 527021010694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021010695 motif II; other site 527021010696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021010697 active site 527021010698 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 527021010699 active site 527021010700 dimer interface [polypeptide binding]; other site 527021010701 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 527021010702 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 527021010703 heterodimer interface [polypeptide binding]; other site 527021010704 active site 527021010705 FMN binding site [chemical binding]; other site 527021010706 homodimer interface [polypeptide binding]; other site 527021010707 substrate binding site [chemical binding]; other site 527021010708 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 527021010709 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 527021010710 FAD binding pocket [chemical binding]; other site 527021010711 FAD binding motif [chemical binding]; other site 527021010712 phosphate binding motif [ion binding]; other site 527021010713 beta-alpha-beta structure motif; other site 527021010714 NAD binding pocket [chemical binding]; other site 527021010715 Iron coordination center [ion binding]; other site 527021010716 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 527021010717 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 527021010718 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 527021010719 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 527021010720 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 527021010721 ATP-grasp domain; Region: ATP-grasp_4; cl17255 527021010722 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 527021010723 IMP binding site; other site 527021010724 dimer interface [polypeptide binding]; other site 527021010725 interdomain contacts; other site 527021010726 partial ornithine binding site; other site 527021010727 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 527021010728 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 527021010729 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 527021010730 catalytic site [active] 527021010731 subunit interface [polypeptide binding]; other site 527021010732 dihydroorotase; Validated; Region: pyrC; PRK09357 527021010733 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 527021010734 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 527021010735 active site 527021010736 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 527021010737 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 527021010738 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 527021010739 uracil transporter; Provisional; Region: PRK10720 527021010740 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 527021010741 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021010742 active site 527021010743 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 527021010744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021010745 RNA binding surface [nucleotide binding]; other site 527021010746 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 527021010747 active site 527021010748 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 527021010749 lipoprotein signal peptidase; Provisional; Region: PRK14787 527021010750 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 527021010751 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 527021010752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 527021010753 active site 527021010754 HIGH motif; other site 527021010755 nucleotide binding site [chemical binding]; other site 527021010756 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 527021010757 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 527021010758 active site 527021010759 KMSKS motif; other site 527021010760 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 527021010761 tRNA binding surface [nucleotide binding]; other site 527021010762 anticodon binding site; other site 527021010763 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 527021010764 DivIVA protein; Region: DivIVA; pfam05103 527021010765 DivIVA domain; Region: DivI1A_domain; TIGR03544 527021010766 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 527021010767 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 527021010768 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021010769 RNA binding surface [nucleotide binding]; other site 527021010770 YGGT family; Region: YGGT; pfam02325 527021010771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 527021010772 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 527021010773 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 527021010774 catalytic residue [active] 527021010775 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 527021010776 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 527021010777 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 527021010778 sporulation sigma factor SigG; Reviewed; Region: PRK08215 527021010779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021010780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021010781 DNA binding residues [nucleotide binding] 527021010782 sporulation sigma factor SigE; Reviewed; Region: PRK08301 527021010783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021010784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021010785 DNA binding residues [nucleotide binding] 527021010786 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 527021010787 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 527021010788 cell division protein FtsZ; Validated; Region: PRK09330 527021010789 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 527021010790 nucleotide binding site [chemical binding]; other site 527021010791 SulA interaction site; other site 527021010792 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 527021010793 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 527021010794 nucleotide binding site [chemical binding]; other site 527021010795 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 527021010796 Cell division protein FtsA; Region: FtsA; pfam14450 527021010797 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 527021010798 Cell division protein FtsQ; Region: FtsQ; pfam03799 527021010799 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 527021010800 FAD binding domain; Region: FAD_binding_4; pfam01565 527021010801 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 527021010802 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 527021010803 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 527021010804 active site 527021010805 homodimer interface [polypeptide binding]; other site 527021010806 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 527021010807 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 527021010808 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 527021010809 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 527021010810 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 527021010811 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 527021010812 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 527021010813 Mg++ binding site [ion binding]; other site 527021010814 putative catalytic motif [active] 527021010815 putative substrate binding site [chemical binding]; other site 527021010816 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 527021010817 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 527021010818 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 527021010819 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 527021010820 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 527021010821 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021010822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021010823 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 527021010824 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 527021010825 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021010826 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021010827 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 527021010828 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 527021010829 Cell division protein FtsL; Region: FtsL; cl11433 527021010830 MraW methylase family; Region: Methyltransf_5; pfam01795 527021010831 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 527021010832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 527021010833 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 527021010834 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 527021010835 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 527021010836 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 527021010837 hypothetical protein; Provisional; Region: PRK13688 527021010838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021010839 Coenzyme A binding pocket [chemical binding]; other site 527021010840 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 527021010841 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 527021010842 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 527021010843 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 527021010844 hypothetical protein; Provisional; Region: PRK13670 527021010845 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 527021010846 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 527021010847 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 527021010848 protein binding site [polypeptide binding]; other site 527021010849 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 527021010850 hypothetical protein; Provisional; Region: PRK10279 527021010851 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 527021010852 active site 527021010853 nucleophile elbow; other site 527021010854 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 527021010855 Nucleoside recognition; Region: Gate; pfam07670 527021010856 Nucleoside recognition; Region: Gate; pfam07670 527021010857 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 527021010858 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 527021010859 active site 527021010860 (T/H)XGH motif; other site 527021010861 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 527021010862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021010863 S-adenosylmethionine binding site [chemical binding]; other site 527021010864 hypothetical protein; Provisional; Region: PRK02886 527021010865 Protein of unknown function (DUF964); Region: DUF964; pfam06133 527021010866 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 527021010867 catalytic core [active] 527021010868 YlbE-like protein; Region: YlbE; pfam14003 527021010869 Putative coat protein; Region: YlbD_coat; pfam14071 527021010870 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 527021010871 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 527021010872 YugN-like family; Region: YugN; pfam08868 527021010873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 527021010874 Helix-turn-helix domain; Region: HTH_28; pfam13518 527021010875 putative transposase OrfB; Reviewed; Region: PHA02517 527021010876 HTH-like domain; Region: HTH_21; pfam13276 527021010877 Integrase core domain; Region: rve; pfam00665 527021010878 Integrase core domain; Region: rve_2; pfam13333 527021010879 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 527021010880 active site 527021010881 catalytic triad [active] 527021010882 dimer interface [polypeptide binding]; other site 527021010883 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 527021010884 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 527021010885 putative active site [active] 527021010886 putative NTP binding site [chemical binding]; other site 527021010887 putative nucleic acid binding site [nucleotide binding]; other site 527021010888 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 527021010889 active site 527021010890 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 527021010891 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 527021010892 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 527021010893 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 527021010894 Subunit I/III interface [polypeptide binding]; other site 527021010895 Subunit III/IV interface [polypeptide binding]; other site 527021010896 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 527021010897 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 527021010898 D-pathway; other site 527021010899 Putative ubiquinol binding site [chemical binding]; other site 527021010900 Low-spin heme (heme b) binding site [chemical binding]; other site 527021010901 Putative water exit pathway; other site 527021010902 Binuclear center (heme o3/CuB) [ion binding]; other site 527021010903 K-pathway; other site 527021010904 Putative proton exit pathway; other site 527021010905 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 527021010906 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 527021010907 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 527021010908 Cytochrome c; Region: Cytochrom_C; pfam00034 527021010909 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 527021010910 UbiA prenyltransferase family; Region: UbiA; pfam01040 527021010911 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 527021010912 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 527021010913 pyruvate carboxylase; Reviewed; Region: PRK12999 527021010914 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 527021010915 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 527021010916 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 527021010917 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 527021010918 active site 527021010919 catalytic residues [active] 527021010920 metal binding site [ion binding]; metal-binding site 527021010921 homodimer binding site [polypeptide binding]; other site 527021010922 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 527021010923 carboxyltransferase (CT) interaction site; other site 527021010924 biotinylation site [posttranslational modification]; other site 527021010925 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 527021010926 hypothetical protein; Provisional; Region: PRK13666 527021010927 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 527021010928 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 527021010929 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 527021010930 putative active site [active] 527021010931 PhoH-like protein; Region: PhoH; pfam02562 527021010932 hypothetical protein; Provisional; Region: PRK06733 527021010933 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 527021010934 YlaH-like protein; Region: YlaH; pfam14036 527021010935 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 527021010936 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 527021010937 G1 box; other site 527021010938 putative GEF interaction site [polypeptide binding]; other site 527021010939 GTP/Mg2+ binding site [chemical binding]; other site 527021010940 Switch I region; other site 527021010941 G2 box; other site 527021010942 G3 box; other site 527021010943 Switch II region; other site 527021010944 G4 box; other site 527021010945 G5 box; other site 527021010946 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 527021010947 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 527021010948 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 527021010949 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 527021010950 active site 527021010951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 527021010952 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 527021010953 hypothetical protein; Provisional; Region: PRK04387 527021010954 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 527021010955 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 527021010956 homodimer interface [polypeptide binding]; other site 527021010957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021010958 catalytic residue [active] 527021010959 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 527021010960 transglutaminase; Provisional; Region: tgl; PRK03187 527021010961 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 527021010962 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 527021010963 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 527021010964 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 527021010965 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 527021010966 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 527021010967 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021010968 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 527021010969 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 527021010970 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 527021010971 E3 interaction surface; other site 527021010972 lipoyl attachment site [posttranslational modification]; other site 527021010973 e3 binding domain; Region: E3_binding; pfam02817 527021010974 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 527021010975 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 527021010976 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 527021010977 alpha subunit interface [polypeptide binding]; other site 527021010978 TPP binding site [chemical binding]; other site 527021010979 heterodimer interface [polypeptide binding]; other site 527021010980 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 527021010981 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 527021010982 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 527021010983 TPP-binding site [chemical binding]; other site 527021010984 heterodimer interface [polypeptide binding]; other site 527021010985 tetramer interface [polypeptide binding]; other site 527021010986 phosphorylation loop region [posttranslational modification] 527021010987 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 527021010988 active site 527021010989 catalytic residues [active] 527021010990 metal binding site [ion binding]; metal-binding site 527021010991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021010992 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 527021010993 active site 527021010994 motif I; other site 527021010995 motif II; other site 527021010996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021010997 hypothetical protein; Provisional; Region: PRK13667 527021010998 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 527021010999 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021011000 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 527021011001 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 527021011002 TrkA-N domain; Region: TrkA_N; pfam02254 527021011003 TrkA-C domain; Region: TrkA_C; pfam02080 527021011004 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 527021011005 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 527021011006 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 527021011007 metal binding site [ion binding]; metal-binding site 527021011008 putative dimer interface [polypeptide binding]; other site 527021011009 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 527021011010 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 527021011011 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 527021011012 trimer interface [polypeptide binding]; other site 527021011013 active site 527021011014 substrate binding site [chemical binding]; other site 527021011015 CoA binding site [chemical binding]; other site 527021011016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021011017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021011018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 527021011019 dimerization interface [polypeptide binding]; other site 527021011020 FOG: CBS domain [General function prediction only]; Region: COG0517 527021011021 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 527021011022 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 527021011023 Protein of unknown function (DUF458); Region: DUF458; pfam04308 527021011024 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 527021011025 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 527021011026 catalytic residues [active] 527021011027 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 527021011028 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 527021011029 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 527021011030 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 527021011031 short chain dehydrogenase; Provisional; Region: PRK07677 527021011032 NAD(P) binding site [chemical binding]; other site 527021011033 substrate binding site [chemical binding]; other site 527021011034 homotetramer interface [polypeptide binding]; other site 527021011035 active site 527021011036 homodimer interface [polypeptide binding]; other site 527021011037 phosphodiesterase YaeI; Provisional; Region: PRK11340 527021011038 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 527021011039 putative active site [active] 527021011040 putative metal binding site [ion binding]; other site 527021011041 polyphosphate kinase; Provisional; Region: PRK05443 527021011042 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 527021011043 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 527021011044 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 527021011045 putative domain interface [polypeptide binding]; other site 527021011046 putative active site [active] 527021011047 catalytic site [active] 527021011048 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 527021011049 putative domain interface [polypeptide binding]; other site 527021011050 putative active site [active] 527021011051 catalytic site [active] 527021011052 exopolyphosphatase; Region: exo_poly_only; TIGR03706 527021011053 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 527021011054 YkyB-like protein; Region: YkyB; pfam14177 527021011055 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 527021011056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 527021011057 I-site; other site 527021011058 active site 527021011059 metal binding site [ion binding]; metal-binding site 527021011060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021011061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021011062 putative substrate translocation pore; other site 527021011063 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021011064 Transcriptional regulator PadR-like family; Region: PadR; cl17335 527021011065 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 527021011066 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 527021011067 THF binding site; other site 527021011068 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 527021011069 substrate binding site [chemical binding]; other site 527021011070 THF binding site; other site 527021011071 zinc-binding site [ion binding]; other site 527021011072 Competence protein J (ComJ); Region: ComJ; pfam11033 527021011073 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 527021011074 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 527021011075 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 527021011076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021011077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021011078 dimer interface [polypeptide binding]; other site 527021011079 phosphorylation site [posttranslational modification] 527021011080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021011081 ATP binding site [chemical binding]; other site 527021011082 Mg2+ binding site [ion binding]; other site 527021011083 G-X-G motif; other site 527021011084 aminotransferase A; Validated; Region: PRK07683 527021011085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021011086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021011087 homodimer interface [polypeptide binding]; other site 527021011088 catalytic residue [active] 527021011089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 527021011090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 527021011091 DNA binding site [nucleotide binding] 527021011092 domain linker motif; other site 527021011093 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 527021011094 putative dimerization interface [polypeptide binding]; other site 527021011095 putative ligand binding site [chemical binding]; other site 527021011096 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 527021011097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021011098 dimer interface [polypeptide binding]; other site 527021011099 conserved gate region; other site 527021011100 putative PBP binding loops; other site 527021011101 ABC-ATPase subunit interface; other site 527021011102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021011103 dimer interface [polypeptide binding]; other site 527021011104 conserved gate region; other site 527021011105 putative PBP binding loops; other site 527021011106 ABC-ATPase subunit interface; other site 527021011107 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 527021011108 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 527021011109 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 527021011110 homodimer interface [polypeptide binding]; other site 527021011111 maltodextrin glucosidase; Provisional; Region: PRK10785 527021011112 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 527021011113 active site 527021011114 homodimer interface [polypeptide binding]; other site 527021011115 catalytic site [active] 527021011116 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 527021011117 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 527021011118 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 527021011119 Ca binding site [ion binding]; other site 527021011120 active site 527021011121 catalytic site [active] 527021011122 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 527021011123 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 527021011124 Walker A/P-loop; other site 527021011125 ATP binding site [chemical binding]; other site 527021011126 Q-loop/lid; other site 527021011127 ABC transporter signature motif; other site 527021011128 Walker B; other site 527021011129 D-loop; other site 527021011130 H-loop/switch region; other site 527021011131 TOBE domain; Region: TOBE_2; pfam08402 527021011132 hypothetical protein; Provisional; Region: PRK06720 527021011133 NAD(P) binding site [chemical binding]; other site 527021011134 RDD family; Region: RDD; pfam06271 527021011135 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 527021011136 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 527021011137 Predicted ATPase [General function prediction only]; Region: COG3910 527021011138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021011139 Walker A/P-loop; other site 527021011140 ATP binding site [chemical binding]; other site 527021011141 Q-loop/lid; other site 527021011142 ABC transporter signature motif; other site 527021011143 Walker B; other site 527021011144 D-loop; other site 527021011145 H-loop/switch region; other site 527021011146 putative acyltransferase; Provisional; Region: PRK05790 527021011147 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 527021011148 dimer interface [polypeptide binding]; other site 527021011149 active site 527021011150 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 527021011151 nudix motif; other site 527021011152 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 527021011153 hypothetical protein; Validated; Region: PRK07668 527021011154 hypothetical protein; Validated; Region: PRK07668 527021011155 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021011156 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 527021011157 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 527021011158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021011159 NAD(P) binding site [chemical binding]; other site 527021011160 active site 527021011161 YvrJ protein family; Region: YvrJ; pfam12841 527021011162 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 527021011163 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 527021011164 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 527021011165 Phosphotransferase enzyme family; Region: APH; pfam01636 527021011166 Predicted amidohydrolase [General function prediction only]; Region: COG0388 527021011167 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 527021011168 putative active site [active] 527021011169 catalytic triad [active] 527021011170 putative dimer interface [polypeptide binding]; other site 527021011171 transaminase; Reviewed; Region: PRK08068 527021011172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021011173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021011174 homodimer interface [polypeptide binding]; other site 527021011175 catalytic residue [active] 527021011176 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 527021011177 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 527021011178 dimer interface [polypeptide binding]; other site 527021011179 active site 527021011180 catalytic residue [active] 527021011181 metal binding site [ion binding]; metal-binding site 527021011182 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 527021011183 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 527021011184 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 527021011185 intersubunit interface [polypeptide binding]; other site 527021011186 active site 527021011187 Zn2+ binding site [ion binding]; other site 527021011188 ARD/ARD' family; Region: ARD; pfam03079 527021011189 Cupin domain; Region: Cupin_2; pfam07883 527021011190 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 527021011191 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 527021011192 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 527021011193 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 527021011194 Beta-lactamase; Region: Beta-lactamase; pfam00144 527021011195 PAS domain; Region: PAS_8; pfam13188 527021011196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 527021011197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 527021011198 metal binding site [ion binding]; metal-binding site 527021011199 active site 527021011200 I-site; other site 527021011201 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 527021011202 dimer interface [polypeptide binding]; other site 527021011203 FMN binding site [chemical binding]; other site 527021011204 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 527021011205 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 527021011206 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 527021011207 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 527021011208 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 527021011209 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 527021011210 dimerization domain swap beta strand [polypeptide binding]; other site 527021011211 regulatory protein interface [polypeptide binding]; other site 527021011212 active site 527021011213 regulatory phosphorylation site [posttranslational modification]; other site 527021011214 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 527021011215 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 527021011216 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 527021011217 active site turn [active] 527021011218 phosphorylation site [posttranslational modification] 527021011219 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 527021011220 HPr interaction site; other site 527021011221 glycerol kinase (GK) interaction site [polypeptide binding]; other site 527021011222 active site 527021011223 phosphorylation site [posttranslational modification] 527021011224 transcriptional antiterminator BglG; Provisional; Region: PRK09772 527021011225 CAT RNA binding domain; Region: CAT_RBD; smart01061 527021011226 PRD domain; Region: PRD; pfam00874 527021011227 PRD domain; Region: PRD; pfam00874 527021011228 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 527021011229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021011230 active site 527021011231 motif I; other site 527021011232 motif II; other site 527021011233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021011234 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 527021011235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021011236 DNA-binding site [nucleotide binding]; DNA binding site 527021011237 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 527021011238 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 527021011239 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 527021011240 active site 527021011241 trimer interface [polypeptide binding]; other site 527021011242 allosteric site; other site 527021011243 active site lid [active] 527021011244 hexamer (dimer of trimers) interface [polypeptide binding]; other site 527021011245 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 527021011246 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 527021011247 active site 527021011248 dimer interface [polypeptide binding]; other site 527021011249 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 527021011250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021011251 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 527021011252 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 527021011253 Domain of unknown function (DUF309); Region: DUF309; pfam03745 527021011254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021011255 Coenzyme A binding pocket [chemical binding]; other site 527021011256 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 527021011257 active site 527021011258 Predicted secreted protein [Function unknown]; Region: COG4086 527021011259 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 527021011260 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 527021011261 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 527021011262 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 527021011263 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021011264 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 527021011265 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 527021011266 stage V sporulation protein AD; Validated; Region: PRK08304 527021011267 stage V sporulation protein AD; Provisional; Region: PRK12404 527021011268 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 527021011269 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 527021011270 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 527021011271 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 527021011272 Na2 binding site [ion binding]; other site 527021011273 putative substrate binding site 1 [chemical binding]; other site 527021011274 Na binding site 1 [ion binding]; other site 527021011275 putative substrate binding site 2 [chemical binding]; other site 527021011276 sporulation sigma factor SigF; Validated; Region: PRK05572 527021011277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021011278 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 527021011279 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021011280 DNA binding residues [nucleotide binding] 527021011281 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 527021011282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021011283 ATP binding site [chemical binding]; other site 527021011284 Mg2+ binding site [ion binding]; other site 527021011285 G-X-G motif; other site 527021011286 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 527021011287 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 527021011288 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021011289 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 527021011290 Predicted transcriptional regulators [Transcription]; Region: COG1725 527021011291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021011292 DNA-binding site [nucleotide binding]; DNA binding site 527021011293 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021011294 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021011295 Walker A/P-loop; other site 527021011296 ATP binding site [chemical binding]; other site 527021011297 Q-loop/lid; other site 527021011298 ABC transporter signature motif; other site 527021011299 Walker B; other site 527021011300 D-loop; other site 527021011301 H-loop/switch region; other site 527021011302 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021011303 MarR family; Region: MarR; pfam01047 527021011304 MarR family; Region: MarR_2; cl17246 527021011305 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 527021011306 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 527021011307 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 527021011308 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 527021011309 oligomer interface [polypeptide binding]; other site 527021011310 metal binding site [ion binding]; metal-binding site 527021011311 metal binding site [ion binding]; metal-binding site 527021011312 putative Cl binding site [ion binding]; other site 527021011313 aspartate ring; other site 527021011314 basic sphincter; other site 527021011315 hydrophobic gate; other site 527021011316 periplasmic entrance; other site 527021011317 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 527021011318 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 527021011319 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 527021011320 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 527021011321 purine nucleoside phosphorylase; Provisional; Region: PRK08202 527021011322 phosphopentomutase; Provisional; Region: PRK05362 527021011323 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 527021011324 YtkA-like; Region: YtkA; pfam13115 527021011325 YtkA-like; Region: YtkA; pfam13115 527021011326 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 527021011327 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 527021011328 active site 527021011329 Int/Topo IB signature motif; other site 527021011330 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 527021011331 ferric uptake regulator; Provisional; Region: fur; PRK09462 527021011332 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 527021011333 metal binding site 2 [ion binding]; metal-binding site 527021011334 putative DNA binding helix; other site 527021011335 metal binding site 1 [ion binding]; metal-binding site 527021011336 dimer interface [polypeptide binding]; other site 527021011337 structural Zn2+ binding site [ion binding]; other site 527021011338 stage II sporulation protein M; Region: spo_II_M; TIGR02831 527021011339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021011340 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021011341 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 527021011342 dimer interface [polypeptide binding]; other site 527021011343 ADP-ribose binding site [chemical binding]; other site 527021011344 active site 527021011345 nudix motif; other site 527021011346 metal binding site [ion binding]; metal-binding site 527021011347 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 527021011348 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 527021011349 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 527021011350 active site 527021011351 catalytic tetrad [active] 527021011352 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 527021011353 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 527021011354 active site 527021011355 catalytic tetrad [active] 527021011356 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 527021011357 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 527021011358 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 527021011359 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 527021011360 putative active site [active] 527021011361 putative metal binding site [ion binding]; other site 527021011362 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 527021011363 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 527021011364 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021011365 Predicted permease [General function prediction only]; Region: COG2056 527021011366 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 527021011367 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 527021011368 Transcriptional regulators [Transcription]; Region: PurR; COG1609 527021011369 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 527021011370 DNA binding site [nucleotide binding] 527021011371 domain linker motif; other site 527021011372 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 527021011373 dimerization interface [polypeptide binding]; other site 527021011374 ligand binding site [chemical binding]; other site 527021011375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021011376 Coenzyme A binding pocket [chemical binding]; other site 527021011377 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021011378 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 527021011379 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 527021011380 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 527021011381 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 527021011382 catalytic motif [active] 527021011383 Zn binding site [ion binding]; other site 527021011384 RibD C-terminal domain; Region: RibD_C; cl17279 527021011385 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 527021011386 Lumazine binding domain; Region: Lum_binding; pfam00677 527021011387 Lumazine binding domain; Region: Lum_binding; pfam00677 527021011388 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 527021011389 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 527021011390 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 527021011391 dimerization interface [polypeptide binding]; other site 527021011392 active site 527021011393 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 527021011394 homopentamer interface [polypeptide binding]; other site 527021011395 active site 527021011396 biotin synthase; Validated; Region: PRK06256 527021011397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021011398 FeS/SAM binding site; other site 527021011399 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 527021011400 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 527021011401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021011402 S-adenosylmethionine binding site [chemical binding]; other site 527021011403 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021011404 Protein of unknown function (DUF452); Region: DUF452; cl01062 527021011405 TAP-like protein; Region: Abhydrolase_4; pfam08386 527021011406 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 527021011407 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 527021011408 substrate-cofactor binding pocket; other site 527021011409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021011410 catalytic residue [active] 527021011411 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 527021011412 AAA domain; Region: AAA_26; pfam13500 527021011413 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 527021011414 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 527021011415 inhibitor-cofactor binding pocket; inhibition site 527021011416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021011417 catalytic residue [active] 527021011418 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 527021011419 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 527021011420 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 527021011421 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 527021011422 active site 527021011423 metal binding site [ion binding]; metal-binding site 527021011424 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 527021011425 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 527021011426 active site 527021011427 catalytic triad [active] 527021011428 oxyanion hole [active] 527021011429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021011430 dimerization interface [polypeptide binding]; other site 527021011431 putative DNA binding site [nucleotide binding]; other site 527021011432 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021011433 putative Zn2+ binding site [ion binding]; other site 527021011434 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 527021011435 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 527021011436 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 527021011437 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 527021011438 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 527021011439 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 527021011440 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 527021011441 ornithine carbamoyltransferase; Provisional; Region: PRK00779 527021011442 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 527021011443 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 527021011444 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 527021011445 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 527021011446 inhibitor-cofactor binding pocket; inhibition site 527021011447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021011448 catalytic residue [active] 527021011449 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 527021011450 nucleotide binding site [chemical binding]; other site 527021011451 N-acetyl-L-glutamate binding site [chemical binding]; other site 527021011452 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 527021011453 heterotetramer interface [polypeptide binding]; other site 527021011454 active site pocket [active] 527021011455 cleavage site 527021011456 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 527021011457 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 527021011458 YqzH-like protein; Region: YqzH; pfam14164 527021011459 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 527021011460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021011461 NAD(P) binding site [chemical binding]; other site 527021011462 active site 527021011463 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021011464 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 527021011465 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 527021011466 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 527021011467 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 527021011468 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 527021011469 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 527021011470 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 527021011471 putative L-serine binding site [chemical binding]; other site 527021011472 ribonuclease Z; Region: RNase_Z; TIGR02651 527021011473 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 527021011474 magnesium-transporting ATPase; Provisional; Region: PRK15122 527021011475 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 527021011476 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 527021011477 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 527021011478 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 527021011479 Soluble P-type ATPase [General function prediction only]; Region: COG4087 527021011480 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 527021011481 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 527021011482 MgtC family; Region: MgtC; pfam02308 527021011483 DNA polymerase IV; Validated; Region: PRK01810 527021011484 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 527021011485 active site 527021011486 DNA binding site [nucleotide binding] 527021011487 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 527021011488 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 527021011489 peptidase T-like protein; Region: PepT-like; TIGR01883 527021011490 metal binding site [ion binding]; metal-binding site 527021011491 putative dimer interface [polypeptide binding]; other site 527021011492 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 527021011493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021011494 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 527021011495 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 527021011496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 527021011497 Predicted membrane protein [Function unknown]; Region: COG4129 527021011498 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 527021011499 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 527021011500 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 527021011501 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 527021011502 Walker A/P-loop; other site 527021011503 ATP binding site [chemical binding]; other site 527021011504 Q-loop/lid; other site 527021011505 ABC transporter signature motif; other site 527021011506 Walker B; other site 527021011507 D-loop; other site 527021011508 H-loop/switch region; other site 527021011509 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 527021011510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021011511 dimer interface [polypeptide binding]; other site 527021011512 conserved gate region; other site 527021011513 putative PBP binding loops; other site 527021011514 ABC-ATPase subunit interface; other site 527021011515 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 527021011516 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 527021011517 substrate binding pocket [chemical binding]; other site 527021011518 membrane-bound complex binding site; other site 527021011519 hinge residues; other site 527021011520 Disulphide isomerase; Region: Disulph_isomer; pfam06491 527021011521 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 527021011522 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 527021011523 nudix motif; other site 527021011524 Predicted membrane protein [Function unknown]; Region: COG2323 527021011525 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 527021011526 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 527021011527 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 527021011528 E3 interaction surface; other site 527021011529 lipoyl attachment site [posttranslational modification]; other site 527021011530 e3 binding domain; Region: E3_binding; pfam02817 527021011531 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 527021011532 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 527021011533 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 527021011534 alpha subunit interface [polypeptide binding]; other site 527021011535 TPP binding site [chemical binding]; other site 527021011536 heterodimer interface [polypeptide binding]; other site 527021011537 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 527021011538 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 527021011539 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 527021011540 tetramer interface [polypeptide binding]; other site 527021011541 TPP-binding site [chemical binding]; other site 527021011542 heterodimer interface [polypeptide binding]; other site 527021011543 phosphorylation loop region [posttranslational modification] 527021011544 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 527021011545 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 527021011546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021011547 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 527021011548 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 527021011549 nucleotide binding site [chemical binding]; other site 527021011550 Acetokinase family; Region: Acetate_kinase; cl17229 527021011551 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 527021011552 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 527021011553 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 527021011554 NAD binding site [chemical binding]; other site 527021011555 Phe binding site; other site 527021011556 phosphate butyryltransferase; Validated; Region: PRK07742 527021011557 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 527021011558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021011559 putative active site [active] 527021011560 heme pocket [chemical binding]; other site 527021011561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021011562 putative active site [active] 527021011563 heme pocket [chemical binding]; other site 527021011564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021011565 Walker A motif; other site 527021011566 ATP binding site [chemical binding]; other site 527021011567 Walker B motif; other site 527021011568 arginine finger; other site 527021011569 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 527021011570 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 527021011571 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 527021011572 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 527021011573 active site 527021011574 catalytic site [active] 527021011575 metal binding site [ion binding]; metal-binding site 527021011576 dimer interface [polypeptide binding]; other site 527021011577 YycC-like protein; Region: YycC; pfam14174 527021011578 hypothetical protein; Provisional; Region: PRK06770 527021011579 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 527021011580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021011581 active site 527021011582 phosphorylation site [posttranslational modification] 527021011583 intermolecular recognition site; other site 527021011584 dimerization interface [polypeptide binding]; other site 527021011585 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 527021011586 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 527021011587 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 527021011588 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 527021011589 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 527021011590 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 527021011591 Walker A/P-loop; other site 527021011592 ATP binding site [chemical binding]; other site 527021011593 Q-loop/lid; other site 527021011594 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 527021011595 ABC transporter signature motif; other site 527021011596 Walker B; other site 527021011597 D-loop; other site 527021011598 H-loop/switch region; other site 527021011599 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 527021011600 arginine repressor; Provisional; Region: PRK04280 527021011601 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 527021011602 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 527021011603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021011604 RNA binding surface [nucleotide binding]; other site 527021011605 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 527021011606 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 527021011607 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 527021011608 TPP-binding site; other site 527021011609 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 527021011610 PYR/PP interface [polypeptide binding]; other site 527021011611 dimer interface [polypeptide binding]; other site 527021011612 TPP binding site [chemical binding]; other site 527021011613 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 527021011614 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 527021011615 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 527021011616 substrate binding pocket [chemical binding]; other site 527021011617 chain length determination region; other site 527021011618 substrate-Mg2+ binding site; other site 527021011619 catalytic residues [active] 527021011620 aspartate-rich region 1; other site 527021011621 active site lid residues [active] 527021011622 aspartate-rich region 2; other site 527021011623 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 527021011624 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 527021011625 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 527021011626 generic binding surface II; other site 527021011627 generic binding surface I; other site 527021011628 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 527021011629 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 527021011630 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 527021011631 homodimer interface [polypeptide binding]; other site 527021011632 NADP binding site [chemical binding]; other site 527021011633 substrate binding site [chemical binding]; other site 527021011634 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 527021011635 putative RNA binding site [nucleotide binding]; other site 527021011636 Asp23 family; Region: Asp23; pfam03780 527021011637 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 527021011638 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 527021011639 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 527021011640 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 527021011641 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 527021011642 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 527021011643 carboxyltransferase (CT) interaction site; other site 527021011644 biotinylation site [posttranslational modification]; other site 527021011645 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 527021011646 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 527021011647 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 527021011648 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 527021011649 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 527021011650 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 527021011651 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 527021011652 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 527021011653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021011654 Walker A motif; other site 527021011655 ATP binding site [chemical binding]; other site 527021011656 Walker B motif; other site 527021011657 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 527021011658 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021011659 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021011660 elongation factor P; Validated; Region: PRK00529 527021011661 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 527021011662 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 527021011663 RNA binding site [nucleotide binding]; other site 527021011664 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 527021011665 RNA binding site [nucleotide binding]; other site 527021011666 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 527021011667 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 527021011668 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 527021011669 active site 527021011670 Dehydroquinase class II; Region: DHquinase_II; pfam01220 527021011671 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 527021011672 trimer interface [polypeptide binding]; other site 527021011673 active site 527021011674 dimer interface [polypeptide binding]; other site 527021011675 Conserved membrane protein YqhR; Region: YqhR; pfam11085 527021011676 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 527021011677 Carbon starvation protein CstA; Region: CstA; pfam02554 527021011678 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 527021011679 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 527021011680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021011681 motif II; other site 527021011682 manganese transport transcriptional regulator; Provisional; Region: PRK03902 527021011683 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 527021011684 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 527021011685 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 527021011686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021011687 FeS/SAM binding site; other site 527021011688 Predicted transcriptional regulators [Transcription]; Region: COG1695 527021011689 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 527021011690 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 527021011691 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 527021011692 active site residue [active] 527021011693 Transcriptional regulators [Transcription]; Region: PurR; COG1609 527021011694 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 527021011695 DNA binding site [nucleotide binding] 527021011696 domain linker motif; other site 527021011697 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 527021011698 putative dimerization interface [polypeptide binding]; other site 527021011699 putative ligand binding site [chemical binding]; other site 527021011700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021011701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021011702 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 527021011703 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 527021011704 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 527021011705 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 527021011706 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 527021011707 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 527021011708 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021011709 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021011710 Walker A/P-loop; other site 527021011711 ATP binding site [chemical binding]; other site 527021011712 Q-loop/lid; other site 527021011713 ABC transporter signature motif; other site 527021011714 Walker B; other site 527021011715 D-loop; other site 527021011716 H-loop/switch region; other site 527021011717 Predicted transcriptional regulators [Transcription]; Region: COG1725 527021011718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021011719 DNA-binding site [nucleotide binding]; DNA binding site 527021011720 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 527021011721 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 527021011722 tetramer interface [polypeptide binding]; other site 527021011723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021011724 catalytic residue [active] 527021011725 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 527021011726 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 527021011727 tetramer interface [polypeptide binding]; other site 527021011728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021011729 catalytic residue [active] 527021011730 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 527021011731 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 527021011732 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 527021011733 DEAD-like helicases superfamily; Region: DEXDc; smart00487 527021011734 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021011735 ATP binding site [chemical binding]; other site 527021011736 putative Mg++ binding site [ion binding]; other site 527021011737 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021011738 nucleotide binding region [chemical binding]; other site 527021011739 ATP-binding site [chemical binding]; other site 527021011740 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 527021011741 YqzE-like protein; Region: YqzE; pfam14038 527021011742 shikimate kinase; Reviewed; Region: aroK; PRK00131 527021011743 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 527021011744 ADP binding site [chemical binding]; other site 527021011745 magnesium binding site [ion binding]; other site 527021011746 putative shikimate binding site; other site 527021011747 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 527021011748 ComG operon protein 7; Region: ComGG; pfam14173 527021011749 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 527021011750 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 527021011751 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 527021011752 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 527021011753 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 527021011754 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 527021011755 Type II/IV secretion system protein; Region: T2SE; pfam00437 527021011756 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 527021011757 Walker A motif; other site 527021011758 ATP binding site [chemical binding]; other site 527021011759 Walker B motif; other site 527021011760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021011761 putative DNA binding site [nucleotide binding]; other site 527021011762 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 527021011763 putative Zn2+ binding site [ion binding]; other site 527021011764 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 527021011765 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 527021011766 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 527021011767 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 527021011768 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 527021011769 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 527021011770 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 527021011771 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 527021011772 homodimer interface [polypeptide binding]; other site 527021011773 active site 527021011774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 527021011775 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 527021011776 Probable transposase; Region: OrfB_IS605; pfam01385 527021011777 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 527021011778 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 527021011779 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 527021011780 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 527021011781 substrate binding pocket [chemical binding]; other site 527021011782 dimer interface [polypeptide binding]; other site 527021011783 inhibitor binding site; inhibition site 527021011784 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 527021011785 B12 binding site [chemical binding]; other site 527021011786 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 527021011787 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 527021011788 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 527021011789 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 527021011790 FAD binding site [chemical binding]; other site 527021011791 cystathionine gamma-synthase; Reviewed; Region: PRK08247 527021011792 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 527021011793 homodimer interface [polypeptide binding]; other site 527021011794 substrate-cofactor binding pocket; other site 527021011795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021011796 catalytic residue [active] 527021011797 cystathionine beta-lyase; Provisional; Region: PRK08064 527021011798 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 527021011799 homodimer interface [polypeptide binding]; other site 527021011800 substrate-cofactor binding pocket; other site 527021011801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021011802 catalytic residue [active] 527021011803 Isochorismatase family; Region: Isochorismatase; pfam00857 527021011804 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 527021011805 catalytic triad [active] 527021011806 conserved cis-peptide bond; other site 527021011807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021011808 dimerization interface [polypeptide binding]; other site 527021011809 putative DNA binding site [nucleotide binding]; other site 527021011810 putative Zn2+ binding site [ion binding]; other site 527021011811 Uncharacterized conserved protein [Function unknown]; Region: COG1565 527021011812 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 527021011813 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 527021011814 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 527021011815 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 527021011816 nucleotide binding site [chemical binding]; other site 527021011817 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 527021011818 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 527021011819 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 527021011820 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 527021011821 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 527021011822 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 527021011823 active site 527021011824 Substrate binding site; other site 527021011825 Mg++ binding site; other site 527021011826 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 527021011827 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 527021011828 active site 527021011829 metal binding site [ion binding]; metal-binding site 527021011830 substrate binding site [chemical binding]; other site 527021011831 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 527021011832 PhoU domain; Region: PhoU; pfam01895 527021011833 PhoU domain; Region: PhoU; pfam01895 527021011834 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 527021011835 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 527021011836 Walker A/P-loop; other site 527021011837 ATP binding site [chemical binding]; other site 527021011838 Q-loop/lid; other site 527021011839 ABC transporter signature motif; other site 527021011840 Walker B; other site 527021011841 D-loop; other site 527021011842 H-loop/switch region; other site 527021011843 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 527021011844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021011845 dimer interface [polypeptide binding]; other site 527021011846 conserved gate region; other site 527021011847 putative PBP binding loops; other site 527021011848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 527021011849 ABC-ATPase subunit interface; other site 527021011850 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 527021011851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021011852 dimer interface [polypeptide binding]; other site 527021011853 conserved gate region; other site 527021011854 putative PBP binding loops; other site 527021011855 ABC-ATPase subunit interface; other site 527021011856 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 527021011857 PBP superfamily domain; Region: PBP_like_2; cl17296 527021011858 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 527021011859 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021011860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021011861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021011862 putative substrate translocation pore; other site 527021011863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021011864 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 527021011865 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 527021011866 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 527021011867 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 527021011868 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 527021011869 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 527021011870 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 527021011871 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 527021011872 metal binding site 2 [ion binding]; metal-binding site 527021011873 putative DNA binding helix; other site 527021011874 metal binding site 1 [ion binding]; metal-binding site 527021011875 dimer interface [polypeptide binding]; other site 527021011876 structural Zn2+ binding site [ion binding]; other site 527021011877 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 527021011878 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021011879 ABC-ATPase subunit interface; other site 527021011880 dimer interface [polypeptide binding]; other site 527021011881 putative PBP binding regions; other site 527021011882 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 527021011883 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 527021011884 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021011885 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021011886 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021011887 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021011888 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 527021011889 endonuclease IV; Provisional; Region: PRK01060 527021011890 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 527021011891 AP (apurinic/apyrimidinic) site pocket; other site 527021011892 DNA interaction; other site 527021011893 Metal-binding active site; metal-binding site 527021011894 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 527021011895 DEAD-like helicases superfamily; Region: DEXDc; smart00487 527021011896 ATP binding site [chemical binding]; other site 527021011897 Mg++ binding site [ion binding]; other site 527021011898 motif III; other site 527021011899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021011900 nucleotide binding region [chemical binding]; other site 527021011901 ATP-binding site [chemical binding]; other site 527021011902 YqfQ-like protein; Region: YqfQ; pfam14181 527021011903 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 527021011904 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 527021011905 Uncharacterized conserved protein [Function unknown]; Region: COG0327 527021011906 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 527021011907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 527021011908 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 527021011909 Uncharacterized conserved protein [Function unknown]; Region: COG0327 527021011910 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 527021011911 Family of unknown function (DUF633); Region: DUF633; pfam04816 527021011912 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 527021011913 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 527021011914 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 527021011915 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 527021011916 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 527021011917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021011918 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 527021011919 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021011920 DNA binding residues [nucleotide binding] 527021011921 DNA primase; Validated; Region: dnaG; PRK05667 527021011922 CHC2 zinc finger; Region: zf-CHC2; pfam01807 527021011923 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 527021011924 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 527021011925 active site 527021011926 metal binding site [ion binding]; metal-binding site 527021011927 interdomain interaction site; other site 527021011928 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 527021011929 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 527021011930 PEP synthetase regulatory protein; Provisional; Region: PRK05339 527021011931 HTH domain; Region: HTH_11; pfam08279 527021011932 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 527021011933 FOG: CBS domain [General function prediction only]; Region: COG0517 527021011934 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 527021011935 Recombination protein O N terminal; Region: RecO_N; pfam11967 527021011936 Recombination protein O C terminal; Region: RecO_C; pfam02565 527021011937 YqzL-like protein; Region: YqzL; pfam14006 527021011938 GTPase Era; Reviewed; Region: era; PRK00089 527021011939 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 527021011940 G1 box; other site 527021011941 GTP/Mg2+ binding site [chemical binding]; other site 527021011942 Switch I region; other site 527021011943 G2 box; other site 527021011944 Switch II region; other site 527021011945 G3 box; other site 527021011946 G4 box; other site 527021011947 G5 box; other site 527021011948 KH domain; Region: KH_2; pfam07650 527021011949 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 527021011950 active site 527021011951 catalytic motif [active] 527021011952 Zn binding site [ion binding]; other site 527021011953 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 527021011954 metal-binding heat shock protein; Provisional; Region: PRK00016 527021011955 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 527021011956 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 527021011957 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021011958 Zn2+ binding site [ion binding]; other site 527021011959 Mg2+ binding site [ion binding]; other site 527021011960 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 527021011961 PhoH-like protein; Region: PhoH; pfam02562 527021011962 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 527021011963 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 527021011964 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 527021011965 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 527021011966 Yqey-like protein; Region: YqeY; pfam09424 527021011967 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 527021011968 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 527021011969 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 527021011970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021011971 FeS/SAM binding site; other site 527021011972 TRAM domain; Region: TRAM; cl01282 527021011973 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 527021011974 RNA methyltransferase, RsmE family; Region: TIGR00046 527021011975 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 527021011976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021011977 S-adenosylmethionine binding site [chemical binding]; other site 527021011978 chaperone protein DnaJ; Provisional; Region: PRK14280 527021011979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 527021011980 HSP70 interaction site [polypeptide binding]; other site 527021011981 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 527021011982 substrate binding site [polypeptide binding]; other site 527021011983 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 527021011984 Zn binding sites [ion binding]; other site 527021011985 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 527021011986 dimer interface [polypeptide binding]; other site 527021011987 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 527021011988 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 527021011989 nucleotide binding site [chemical binding]; other site 527021011990 NEF interaction site [polypeptide binding]; other site 527021011991 SBD interface [polypeptide binding]; other site 527021011992 GrpE; Region: GrpE; pfam01025 527021011993 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 527021011994 dimer interface [polypeptide binding]; other site 527021011995 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 527021011996 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 527021011997 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 527021011998 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 527021011999 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021012000 FeS/SAM binding site; other site 527021012001 HemN C-terminal domain; Region: HemN_C; pfam06969 527021012002 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021012003 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 527021012004 GTP-binding protein LepA; Provisional; Region: PRK05433 527021012005 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 527021012006 G1 box; other site 527021012007 putative GEF interaction site [polypeptide binding]; other site 527021012008 GTP/Mg2+ binding site [chemical binding]; other site 527021012009 Switch I region; other site 527021012010 G2 box; other site 527021012011 G3 box; other site 527021012012 Switch II region; other site 527021012013 G4 box; other site 527021012014 G5 box; other site 527021012015 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 527021012016 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 527021012017 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 527021012018 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 527021012019 germination protease; Provisional; Region: PRK02858 527021012020 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 527021012021 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 527021012022 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 527021012023 YqzM-like protein; Region: YqzM; pfam14141 527021012024 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 527021012025 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 527021012026 Competence protein; Region: Competence; pfam03772 527021012027 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021012028 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 527021012029 catalytic motif [active] 527021012030 Zn binding site [ion binding]; other site 527021012031 SLBB domain; Region: SLBB; pfam10531 527021012032 comEA protein; Region: comE; TIGR01259 527021012033 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 527021012034 late competence protein ComER; Validated; Region: PRK07680 527021012035 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 527021012036 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 527021012037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021012038 S-adenosylmethionine binding site [chemical binding]; other site 527021012039 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 527021012040 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 527021012041 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021012042 Zn2+ binding site [ion binding]; other site 527021012043 Mg2+ binding site [ion binding]; other site 527021012044 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 527021012045 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 527021012046 active site 527021012047 (T/H)XGH motif; other site 527021012048 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 527021012049 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 527021012050 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 527021012051 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 527021012052 shikimate binding site; other site 527021012053 NAD(P) binding site [chemical binding]; other site 527021012054 GTPase YqeH; Provisional; Region: PRK13796 527021012055 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 527021012056 GTP/Mg2+ binding site [chemical binding]; other site 527021012057 G4 box; other site 527021012058 G5 box; other site 527021012059 G1 box; other site 527021012060 Switch I region; other site 527021012061 G2 box; other site 527021012062 G3 box; other site 527021012063 Switch II region; other site 527021012064 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 527021012065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021012066 active site 527021012067 motif I; other site 527021012068 motif II; other site 527021012069 Sporulation inhibitor A; Region: Sda; pfam08970 527021012070 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 527021012071 sporulation sigma factor SigK; Reviewed; Region: PRK05803 527021012072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021012073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021012074 DNA binding residues [nucleotide binding] 527021012075 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 527021012076 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 527021012077 dimer interface [polypeptide binding]; other site 527021012078 FMN binding site [chemical binding]; other site 527021012079 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 527021012080 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 527021012081 synthetase active site [active] 527021012082 NTP binding site [chemical binding]; other site 527021012083 metal binding site [ion binding]; metal-binding site 527021012084 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 527021012085 dimer interface [polypeptide binding]; other site 527021012086 Alkaline phosphatase homologues; Region: alkPPc; smart00098 527021012087 active site 527021012088 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021012089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021012090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021012091 Coenzyme A binding pocket [chemical binding]; other site 527021012092 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 527021012093 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021012094 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 527021012095 catalytic site [active] 527021012096 DoxX; Region: DoxX; cl17842 527021012097 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 527021012098 catalytic core [active] 527021012099 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 527021012100 translocation protein TolB; Provisional; Region: tolB; PRK04792 527021012101 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 527021012102 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 527021012103 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 527021012104 putative active site [active] 527021012105 catalytic triad [active] 527021012106 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 527021012107 putative integrin binding motif; other site 527021012108 PA/protease domain interface [polypeptide binding]; other site 527021012109 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 527021012110 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 527021012111 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 527021012112 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 527021012113 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 527021012114 cofactor binding site; other site 527021012115 metal binding site [ion binding]; metal-binding site 527021012116 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 527021012117 aromatic arch; other site 527021012118 DCoH dimer interaction site [polypeptide binding]; other site 527021012119 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 527021012120 DCoH tetramer interaction site [polypeptide binding]; other site 527021012121 substrate binding site [chemical binding]; other site 527021012122 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 527021012123 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 527021012124 putative metal binding site [ion binding]; other site 527021012125 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 527021012126 active site 527021012127 metal binding site [ion binding]; metal-binding site 527021012128 Predicted membrane protein [Function unknown]; Region: COG2259 527021012129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021012130 non-specific DNA binding site [nucleotide binding]; other site 527021012131 salt bridge; other site 527021012132 sequence-specific DNA binding site [nucleotide binding]; other site 527021012133 Cupin domain; Region: Cupin_2; pfam07883 527021012134 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 527021012135 active site 2 [active] 527021012136 active site 1 [active] 527021012137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021012138 Coenzyme A binding pocket [chemical binding]; other site 527021012139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021012140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021012141 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 527021012142 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 527021012143 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 527021012144 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 527021012145 Walker A/P-loop; other site 527021012146 ATP binding site [chemical binding]; other site 527021012147 Q-loop/lid; other site 527021012148 ABC transporter signature motif; other site 527021012149 Walker B; other site 527021012150 D-loop; other site 527021012151 H-loop/switch region; other site 527021012152 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 527021012153 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021012154 ABC-ATPase subunit interface; other site 527021012155 dimer interface [polypeptide binding]; other site 527021012156 putative PBP binding regions; other site 527021012157 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 527021012158 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 527021012159 intersubunit interface [polypeptide binding]; other site 527021012160 YrhC-like protein; Region: YrhC; pfam14143 527021012161 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 527021012162 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 527021012163 putative catalytic cysteine [active] 527021012164 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 527021012165 putative active site [active] 527021012166 metal binding site [ion binding]; metal-binding site 527021012167 cystathionine beta-lyase; Provisional; Region: PRK07671 527021012168 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 527021012169 homodimer interface [polypeptide binding]; other site 527021012170 substrate-cofactor binding pocket; other site 527021012171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021012172 catalytic residue [active] 527021012173 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 527021012174 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 527021012175 dimer interface [polypeptide binding]; other site 527021012176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021012177 catalytic residue [active] 527021012178 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 527021012179 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 527021012180 Methyltransferase domain; Region: Methyltransf_23; pfam13489 527021012181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021012182 S-adenosylmethionine binding site [chemical binding]; other site 527021012183 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 527021012184 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 527021012185 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 527021012186 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 527021012187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021012188 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 527021012189 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 527021012190 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 527021012191 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 527021012192 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 527021012193 ATP-binding site [chemical binding]; other site 527021012194 Sugar specificity; other site 527021012195 Pyrimidine base specificity; other site 527021012196 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 527021012197 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 527021012198 Peptidase family U32; Region: Peptidase_U32; pfam01136 527021012199 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 527021012200 Protein of unknown function (DUF556); Region: DUF556; cl00822 527021012201 Peptidase family U32; Region: Peptidase_U32; pfam01136 527021012202 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 527021012203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021012204 S-adenosylmethionine binding site [chemical binding]; other site 527021012205 YceG-like family; Region: YceG; pfam02618 527021012206 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 527021012207 dimerization interface [polypeptide binding]; other site 527021012208 hypothetical protein; Provisional; Region: PRK13678 527021012209 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 527021012210 hypothetical protein; Provisional; Region: PRK05473 527021012211 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 527021012212 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 527021012213 motif 1; other site 527021012214 active site 527021012215 motif 2; other site 527021012216 motif 3; other site 527021012217 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 527021012218 DHHA1 domain; Region: DHHA1; pfam02272 527021012219 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 527021012220 Domain of unknown function DUF20; Region: UPF0118; pfam01594 527021012221 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 527021012222 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 527021012223 AAA domain; Region: AAA_30; pfam13604 527021012224 Family description; Region: UvrD_C_2; pfam13538 527021012225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021012226 TPR motif; other site 527021012227 binding surface 527021012228 TPR repeat; Region: TPR_11; pfam13414 527021012229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021012230 binding surface 527021012231 TPR motif; other site 527021012232 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021012233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021012234 binding surface 527021012235 TPR motif; other site 527021012236 TPR repeat; Region: TPR_11; pfam13414 527021012237 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 527021012238 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 527021012239 Ligand Binding Site [chemical binding]; other site 527021012240 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 527021012241 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 527021012242 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021012243 catalytic residue [active] 527021012244 Predicted transcriptional regulator [Transcription]; Region: COG1959 527021012245 Transcriptional regulator; Region: Rrf2; pfam02082 527021012246 recombination factor protein RarA; Reviewed; Region: PRK13342 527021012247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021012248 Walker A motif; other site 527021012249 ATP binding site [chemical binding]; other site 527021012250 Walker B motif; other site 527021012251 arginine finger; other site 527021012252 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 527021012253 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 527021012254 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 527021012255 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 527021012256 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 527021012257 putative ATP binding site [chemical binding]; other site 527021012258 putative substrate interface [chemical binding]; other site 527021012259 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 527021012260 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 527021012261 dimer interface [polypeptide binding]; other site 527021012262 anticodon binding site; other site 527021012263 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 527021012264 homodimer interface [polypeptide binding]; other site 527021012265 motif 1; other site 527021012266 active site 527021012267 motif 2; other site 527021012268 GAD domain; Region: GAD; pfam02938 527021012269 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 527021012270 motif 3; other site 527021012271 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 527021012272 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 527021012273 dimer interface [polypeptide binding]; other site 527021012274 motif 1; other site 527021012275 active site 527021012276 motif 2; other site 527021012277 motif 3; other site 527021012278 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 527021012279 anticodon binding site; other site 527021012280 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 527021012281 putative active site [active] 527021012282 dimerization interface [polypeptide binding]; other site 527021012283 putative tRNAtyr binding site [nucleotide binding]; other site 527021012284 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 527021012285 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021012286 Zn2+ binding site [ion binding]; other site 527021012287 Mg2+ binding site [ion binding]; other site 527021012288 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 527021012289 synthetase active site [active] 527021012290 NTP binding site [chemical binding]; other site 527021012291 metal binding site [ion binding]; metal-binding site 527021012292 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 527021012293 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 527021012294 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021012295 active site 527021012296 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 527021012297 DHH family; Region: DHH; pfam01368 527021012298 DHHA1 domain; Region: DHHA1; pfam02272 527021012299 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 527021012300 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 527021012301 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 527021012302 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 527021012303 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 527021012304 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 527021012305 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 527021012306 Protein export membrane protein; Region: SecD_SecF; pfam02355 527021012307 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 527021012308 stage V sporulation protein B; Region: spore_V_B; TIGR02900 527021012309 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 527021012310 Predicted membrane protein [Function unknown]; Region: COG2323 527021012311 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 527021012312 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 527021012313 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 527021012314 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 527021012315 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 527021012316 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 527021012317 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 527021012318 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 527021012319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021012320 Walker A motif; other site 527021012321 ATP binding site [chemical binding]; other site 527021012322 Walker B motif; other site 527021012323 arginine finger; other site 527021012324 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 527021012325 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 527021012326 RuvA N terminal domain; Region: RuvA_N; pfam01330 527021012327 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 527021012328 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 527021012329 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 527021012330 putative ligand binding residues [chemical binding]; other site 527021012331 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 527021012332 BofC C-terminal domain; Region: BofC_C; pfam08955 527021012333 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 527021012334 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021012335 quinolinate synthetase; Provisional; Region: PRK09375 527021012336 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 527021012337 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 527021012338 dimerization interface [polypeptide binding]; other site 527021012339 active site 527021012340 L-aspartate oxidase; Provisional; Region: PRK08071 527021012341 L-aspartate oxidase; Provisional; Region: PRK06175 527021012342 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 527021012343 cysteine desulfurase; Provisional; Region: PRK02948 527021012344 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 527021012345 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021012346 catalytic residue [active] 527021012347 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 527021012348 HTH domain; Region: HTH_11; pfam08279 527021012349 3H domain; Region: 3H; pfam02829 527021012350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 527021012351 MOSC domain; Region: MOSC; pfam03473 527021012352 3-alpha domain; Region: 3-alpha; pfam03475 527021012353 prephenate dehydratase; Provisional; Region: PRK11898 527021012354 Prephenate dehydratase; Region: PDT; pfam00800 527021012355 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 527021012356 putative L-Phe binding site [chemical binding]; other site 527021012357 FtsX-like permease family; Region: FtsX; pfam02687 527021012358 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 527021012359 FtsX-like permease family; Region: FtsX; pfam02687 527021012360 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021012361 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021012362 Walker A/P-loop; other site 527021012363 ATP binding site [chemical binding]; other site 527021012364 Q-loop/lid; other site 527021012365 ABC transporter signature motif; other site 527021012366 Walker B; other site 527021012367 D-loop; other site 527021012368 H-loop/switch region; other site 527021012369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021012370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 527021012371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021012372 ATP binding site [chemical binding]; other site 527021012373 Mg2+ binding site [ion binding]; other site 527021012374 G-X-G motif; other site 527021012375 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021012376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021012377 active site 527021012378 phosphorylation site [posttranslational modification] 527021012379 intermolecular recognition site; other site 527021012380 dimerization interface [polypeptide binding]; other site 527021012381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021012382 DNA binding site [nucleotide binding] 527021012383 GTPase CgtA; Reviewed; Region: obgE; PRK12297 527021012384 GTP1/OBG; Region: GTP1_OBG; pfam01018 527021012385 Obg GTPase; Region: Obg; cd01898 527021012386 G1 box; other site 527021012387 GTP/Mg2+ binding site [chemical binding]; other site 527021012388 Switch I region; other site 527021012389 G2 box; other site 527021012390 G3 box; other site 527021012391 Switch II region; other site 527021012392 G4 box; other site 527021012393 G5 box; other site 527021012394 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 527021012395 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 527021012396 hypothetical protein; Provisional; Region: PRK14553 527021012397 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 527021012398 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 527021012399 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 527021012400 homodimer interface [polypeptide binding]; other site 527021012401 oligonucleotide binding site [chemical binding]; other site 527021012402 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 527021012403 Peptidase family M50; Region: Peptidase_M50; pfam02163 527021012404 active site 527021012405 putative substrate binding region [chemical binding]; other site 527021012406 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 527021012407 Peptidase family M23; Region: Peptidase_M23; pfam01551 527021012408 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 527021012409 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 527021012410 Switch I; other site 527021012411 Switch II; other site 527021012412 septum formation inhibitor; Reviewed; Region: minC; PRK00513 527021012413 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 527021012414 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 527021012415 rod shape-determining protein MreC; Provisional; Region: PRK13922 527021012416 rod shape-determining protein MreC; Region: MreC; pfam04085 527021012417 rod shape-determining protein MreB; Provisional; Region: PRK13927 527021012418 MreB and similar proteins; Region: MreB_like; cd10225 527021012419 nucleotide binding site [chemical binding]; other site 527021012420 Mg binding site [ion binding]; other site 527021012421 putative protofilament interaction site [polypeptide binding]; other site 527021012422 RodZ interaction site [polypeptide binding]; other site 527021012423 hypothetical protein; Reviewed; Region: PRK00024 527021012424 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 527021012425 MPN+ (JAMM) motif; other site 527021012426 Zinc-binding site [ion binding]; other site 527021012427 Maf-like protein; Region: Maf; pfam02545 527021012428 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 527021012429 active site 527021012430 dimer interface [polypeptide binding]; other site 527021012431 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 527021012432 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 527021012433 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 527021012434 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 527021012435 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 527021012436 active site 527021012437 HIGH motif; other site 527021012438 nucleotide binding site [chemical binding]; other site 527021012439 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 527021012440 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 527021012441 active site 527021012442 KMSKS motif; other site 527021012443 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 527021012444 tRNA binding surface [nucleotide binding]; other site 527021012445 anticodon binding site; other site 527021012446 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 527021012447 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 527021012448 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 527021012449 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 527021012450 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021012451 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 527021012452 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 527021012453 inhibitor-cofactor binding pocket; inhibition site 527021012454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021012455 catalytic residue [active] 527021012456 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 527021012457 dimer interface [polypeptide binding]; other site 527021012458 active site 527021012459 Schiff base residues; other site 527021012460 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 527021012461 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 527021012462 active site 527021012463 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 527021012464 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 527021012465 domain interfaces; other site 527021012466 active site 527021012467 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 527021012468 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 527021012469 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 527021012470 tRNA; other site 527021012471 putative tRNA binding site [nucleotide binding]; other site 527021012472 putative NADP binding site [chemical binding]; other site 527021012473 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 527021012474 Transcriptional regulators [Transcription]; Region: MarR; COG1846 527021012475 MarR family; Region: MarR; pfam01047 527021012476 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 527021012477 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 527021012478 G1 box; other site 527021012479 GTP/Mg2+ binding site [chemical binding]; other site 527021012480 Switch I region; other site 527021012481 G2 box; other site 527021012482 G3 box; other site 527021012483 Switch II region; other site 527021012484 G4 box; other site 527021012485 G5 box; other site 527021012486 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 527021012487 Found in ATP-dependent protease La (LON); Region: LON; smart00464 527021012488 Found in ATP-dependent protease La (LON); Region: LON; smart00464 527021012489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021012490 Walker A motif; other site 527021012491 ATP binding site [chemical binding]; other site 527021012492 Walker B motif; other site 527021012493 arginine finger; other site 527021012494 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 527021012495 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 527021012496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021012497 Walker A motif; other site 527021012498 ATP binding site [chemical binding]; other site 527021012499 Walker B motif; other site 527021012500 arginine finger; other site 527021012501 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 527021012502 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 527021012503 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 527021012504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021012505 Walker A motif; other site 527021012506 ATP binding site [chemical binding]; other site 527021012507 Walker B motif; other site 527021012508 arginine finger; other site 527021012509 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 527021012510 trigger factor; Provisional; Region: tig; PRK01490 527021012511 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 527021012512 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 527021012513 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 527021012514 pentamer interface [polypeptide binding]; other site 527021012515 dodecaamer interface [polypeptide binding]; other site 527021012516 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 527021012517 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 527021012518 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 527021012519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021012520 non-specific DNA binding site [nucleotide binding]; other site 527021012521 salt bridge; other site 527021012522 sequence-specific DNA binding site [nucleotide binding]; other site 527021012523 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 527021012524 Helix-turn-helix domain; Region: HTH_36; pfam13730 527021012525 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 527021012526 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 527021012527 catalytic residues [active] 527021012528 catalytic nucleophile [active] 527021012529 Presynaptic Site I dimer interface [polypeptide binding]; other site 527021012530 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 527021012531 Synaptic Flat tetramer interface [polypeptide binding]; other site 527021012532 Synaptic Site I dimer interface [polypeptide binding]; other site 527021012533 DNA binding site [nucleotide binding] 527021012534 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 527021012535 trimer interface [polypeptide binding]; other site 527021012536 active site 527021012537 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 527021012538 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 527021012539 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 527021012540 active site 527021012541 catalytic residues [active] 527021012542 DNA binding site [nucleotide binding] 527021012543 Int/Topo IB signature motif; other site 527021012544 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 527021012545 active site 527021012546 metal binding site [ion binding]; metal-binding site 527021012547 homotetramer interface [polypeptide binding]; other site 527021012548 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 527021012549 active site 527021012550 dimerization interface [polypeptide binding]; other site 527021012551 ribonuclease PH; Reviewed; Region: rph; PRK00173 527021012552 Ribonuclease PH; Region: RNase_PH_bact; cd11362 527021012553 hexamer interface [polypeptide binding]; other site 527021012554 active site 527021012555 Sporulation and spore germination; Region: Germane; pfam10646 527021012556 Spore germination protein [General function prediction only]; Region: COG5401 527021012557 Sporulation and spore germination; Region: Germane; pfam10646 527021012558 glutamate racemase; Provisional; Region: PRK00865 527021012559 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021012560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021012561 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 527021012562 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 527021012563 potential catalytic triad [active] 527021012564 conserved cys residue [active] 527021012565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021012566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021012567 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 527021012568 intracellular protease, PfpI family; Region: PfpI; TIGR01382 527021012569 potential catalytic triad [active] 527021012570 conserved cys residue [active] 527021012571 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021012572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021012573 DNA binding residues [nucleotide binding] 527021012574 dimerization interface [polypeptide binding]; other site 527021012575 putative uracil/xanthine transporter; Provisional; Region: PRK11412 527021012576 putative deaminase; Validated; Region: PRK06846 527021012577 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 527021012578 active site 527021012579 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 527021012580 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021012581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021012582 non-specific DNA binding site [nucleotide binding]; other site 527021012583 salt bridge; other site 527021012584 sequence-specific DNA binding site [nucleotide binding]; other site 527021012585 Cupin domain; Region: Cupin_2; pfam07883 527021012586 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 527021012587 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 527021012588 amphipathic channel; other site 527021012589 Asn-Pro-Ala signature motifs; other site 527021012590 Predicted transcriptional regulator [Transcription]; Region: COG1959 527021012591 Transcriptional regulator; Region: Rrf2; pfam02082 527021012592 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 527021012593 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 527021012594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021012595 Walker A/P-loop; other site 527021012596 ATP binding site [chemical binding]; other site 527021012597 Q-loop/lid; other site 527021012598 ABC transporter signature motif; other site 527021012599 Walker B; other site 527021012600 D-loop; other site 527021012601 H-loop/switch region; other site 527021012602 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 527021012603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021012604 active site 527021012605 motif I; other site 527021012606 motif II; other site 527021012607 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 527021012608 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 527021012609 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 527021012610 ligand binding site [chemical binding]; other site 527021012611 flagellar motor protein MotA; Validated; Region: PRK08124 527021012612 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 527021012613 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 527021012614 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 527021012615 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 527021012616 active site 527021012617 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 527021012618 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 527021012619 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 527021012620 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 527021012621 L-aspartate oxidase; Provisional; Region: PRK06175 527021012622 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 527021012623 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 527021012624 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 527021012625 putative Iron-sulfur protein interface [polypeptide binding]; other site 527021012626 proximal heme binding site [chemical binding]; other site 527021012627 distal heme binding site [chemical binding]; other site 527021012628 putative dimer interface [polypeptide binding]; other site 527021012629 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 527021012630 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 527021012631 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 527021012632 GIY-YIG motif/motif A; other site 527021012633 active site 527021012634 catalytic site [active] 527021012635 putative DNA binding site [nucleotide binding]; other site 527021012636 metal binding site [ion binding]; metal-binding site 527021012637 UvrB/uvrC motif; Region: UVR; pfam02151 527021012638 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 527021012639 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 527021012640 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 527021012641 catalytic residues [active] 527021012642 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 527021012643 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 527021012644 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 527021012645 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 527021012646 Ligand binding site [chemical binding]; other site 527021012647 Electron transfer flavoprotein domain; Region: ETF; pfam01012 527021012648 enoyl-CoA hydratase; Provisional; Region: PRK07658 527021012649 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 527021012650 substrate binding site [chemical binding]; other site 527021012651 oxyanion hole (OAH) forming residues; other site 527021012652 trimer interface [polypeptide binding]; other site 527021012653 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 527021012654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021012655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021012656 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 527021012657 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 527021012658 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 527021012659 acyl-activating enzyme (AAE) consensus motif; other site 527021012660 putative AMP binding site [chemical binding]; other site 527021012661 putative active site [active] 527021012662 putative CoA binding site [chemical binding]; other site 527021012663 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 527021012664 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 527021012665 siderophore binding site; other site 527021012666 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 527021012667 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021012668 ABC-ATPase subunit interface; other site 527021012669 dimer interface [polypeptide binding]; other site 527021012670 putative PBP binding regions; other site 527021012671 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021012672 ABC-ATPase subunit interface; other site 527021012673 dimer interface [polypeptide binding]; other site 527021012674 putative PBP binding regions; other site 527021012675 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 527021012676 DinB family; Region: DinB; pfam05163 527021012677 DinB superfamily; Region: DinB_2; pfam12867 527021012678 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 527021012679 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 527021012680 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 527021012681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021012682 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 527021012683 Walker A/P-loop; other site 527021012684 ATP binding site [chemical binding]; other site 527021012685 Q-loop/lid; other site 527021012686 ABC transporter signature motif; other site 527021012687 Walker B; other site 527021012688 D-loop; other site 527021012689 H-loop/switch region; other site 527021012690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021012691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021012692 dimer interface [polypeptide binding]; other site 527021012693 phosphorylation site [posttranslational modification] 527021012694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021012695 ATP binding site [chemical binding]; other site 527021012696 Mg2+ binding site [ion binding]; other site 527021012697 G-X-G motif; other site 527021012698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021012699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021012700 active site 527021012701 phosphorylation site [posttranslational modification] 527021012702 intermolecular recognition site; other site 527021012703 dimerization interface [polypeptide binding]; other site 527021012704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021012705 DNA binding site [nucleotide binding] 527021012706 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 527021012707 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 527021012708 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 527021012709 putative RNA binding site [nucleotide binding]; other site 527021012710 Methyltransferase domain; Region: Methyltransf_26; pfam13659 527021012711 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 527021012712 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 527021012713 active site 527021012714 catalytic site [active] 527021012715 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 527021012716 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 527021012717 Walker A/P-loop; other site 527021012718 ATP binding site [chemical binding]; other site 527021012719 Q-loop/lid; other site 527021012720 ABC transporter signature motif; other site 527021012721 Walker B; other site 527021012722 D-loop; other site 527021012723 H-loop/switch region; other site 527021012724 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 527021012725 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021012726 ABC-ATPase subunit interface; other site 527021012727 dimer interface [polypeptide binding]; other site 527021012728 putative PBP binding regions; other site 527021012729 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 527021012730 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 527021012731 intersubunit interface [polypeptide binding]; other site 527021012732 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 527021012733 heme-binding site [chemical binding]; other site 527021012734 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 527021012735 heme-binding site [chemical binding]; other site 527021012736 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 527021012737 heme-binding site [chemical binding]; other site 527021012738 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 527021012739 heme-binding site [chemical binding]; other site 527021012740 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 527021012741 heme-binding site [chemical binding]; other site 527021012742 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 527021012743 heme-binding site [chemical binding]; other site 527021012744 heme uptake protein IsdC; Region: IsdC; TIGR03656 527021012745 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 527021012746 heme-binding site [chemical binding]; other site 527021012747 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 527021012748 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 527021012749 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 527021012750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021012751 RNA binding surface [nucleotide binding]; other site 527021012752 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 527021012753 probable active site [active] 527021012754 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 527021012755 MutS domain III; Region: MutS_III; pfam05192 527021012756 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 527021012757 Walker A/P-loop; other site 527021012758 ATP binding site [chemical binding]; other site 527021012759 Q-loop/lid; other site 527021012760 ABC transporter signature motif; other site 527021012761 Walker B; other site 527021012762 D-loop; other site 527021012763 H-loop/switch region; other site 527021012764 Smr domain; Region: Smr; pfam01713 527021012765 hypothetical protein; Provisional; Region: PRK08609 527021012766 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 527021012767 active site 527021012768 primer binding site [nucleotide binding]; other site 527021012769 NTP binding site [chemical binding]; other site 527021012770 metal binding triad [ion binding]; metal-binding site 527021012771 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 527021012772 active site 527021012773 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 527021012774 Colicin V production protein; Region: Colicin_V; pfam02674 527021012775 cell division protein ZapA; Provisional; Region: PRK14126 527021012776 ribonuclease HIII; Provisional; Region: PRK00996 527021012777 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 527021012778 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 527021012779 RNA/DNA hybrid binding site [nucleotide binding]; other site 527021012780 active site 527021012781 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 527021012782 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 527021012783 putative dimer interface [polypeptide binding]; other site 527021012784 putative anticodon binding site; other site 527021012785 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 527021012786 homodimer interface [polypeptide binding]; other site 527021012787 motif 1; other site 527021012788 motif 2; other site 527021012789 active site 527021012790 motif 3; other site 527021012791 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 527021012792 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 527021012793 putative tRNA-binding site [nucleotide binding]; other site 527021012794 B3/4 domain; Region: B3_4; pfam03483 527021012795 tRNA synthetase B5 domain; Region: B5; smart00874 527021012796 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 527021012797 dimer interface [polypeptide binding]; other site 527021012798 motif 1; other site 527021012799 motif 3; other site 527021012800 motif 2; other site 527021012801 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 527021012802 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 527021012803 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 527021012804 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 527021012805 dimer interface [polypeptide binding]; other site 527021012806 motif 1; other site 527021012807 active site 527021012808 motif 2; other site 527021012809 motif 3; other site 527021012810 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 527021012811 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 527021012812 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 527021012813 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 527021012814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021012815 Zn2+ binding site [ion binding]; other site 527021012816 Mg2+ binding site [ion binding]; other site 527021012817 CAAX protease self-immunity; Region: Abi; pfam02517 527021012818 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 527021012819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021012820 putative substrate translocation pore; other site 527021012821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021012822 HlyD family secretion protein; Region: HlyD_3; pfam13437 527021012823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021012824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021012825 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 527021012826 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 527021012827 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 527021012828 oligomer interface [polypeptide binding]; other site 527021012829 active site 527021012830 metal binding site [ion binding]; metal-binding site 527021012831 dUTPase; Region: dUTPase_2; pfam08761 527021012832 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 527021012833 active site 527021012834 homodimer interface [polypeptide binding]; other site 527021012835 metal binding site [ion binding]; metal-binding site 527021012836 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 527021012837 23S rRNA binding site [nucleotide binding]; other site 527021012838 L21 binding site [polypeptide binding]; other site 527021012839 L13 binding site [polypeptide binding]; other site 527021012840 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 527021012841 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 527021012842 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 527021012843 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 527021012844 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 527021012845 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 527021012846 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 527021012847 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 527021012848 active site 527021012849 dimer interface [polypeptide binding]; other site 527021012850 motif 1; other site 527021012851 motif 2; other site 527021012852 motif 3; other site 527021012853 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 527021012854 anticodon binding site; other site 527021012855 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 527021012856 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 527021012857 primosomal protein DnaI; Reviewed; Region: PRK08939 527021012858 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 527021012859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021012860 Walker A motif; other site 527021012861 ATP binding site [chemical binding]; other site 527021012862 Walker B motif; other site 527021012863 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 527021012864 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 527021012865 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 527021012866 ATP cone domain; Region: ATP-cone; pfam03477 527021012867 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 527021012868 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 527021012869 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 527021012870 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 527021012871 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 527021012872 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 527021012873 CoA-binding site [chemical binding]; other site 527021012874 ATP-binding [chemical binding]; other site 527021012875 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 527021012876 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 527021012877 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 527021012878 DNA binding site [nucleotide binding] 527021012879 catalytic residue [active] 527021012880 H2TH interface [polypeptide binding]; other site 527021012881 putative catalytic residues [active] 527021012882 turnover-facilitating residue; other site 527021012883 intercalation triad [nucleotide binding]; other site 527021012884 8OG recognition residue [nucleotide binding]; other site 527021012885 putative reading head residues; other site 527021012886 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 527021012887 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 527021012888 DNA polymerase I; Provisional; Region: PRK05755 527021012889 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 527021012890 active site 527021012891 metal binding site 1 [ion binding]; metal-binding site 527021012892 putative 5' ssDNA interaction site; other site 527021012893 metal binding site 3; metal-binding site 527021012894 metal binding site 2 [ion binding]; metal-binding site 527021012895 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 527021012896 putative DNA binding site [nucleotide binding]; other site 527021012897 putative metal binding site [ion binding]; other site 527021012898 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 527021012899 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 527021012900 active site 527021012901 DNA binding site [nucleotide binding] 527021012902 catalytic site [active] 527021012903 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021012904 dimerization interface [polypeptide binding]; other site 527021012905 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 527021012906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021012907 putative active site [active] 527021012908 heme pocket [chemical binding]; other site 527021012909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021012910 dimer interface [polypeptide binding]; other site 527021012911 phosphorylation site [posttranslational modification] 527021012912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021012913 ATP binding site [chemical binding]; other site 527021012914 Mg2+ binding site [ion binding]; other site 527021012915 G-X-G motif; other site 527021012916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021012917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021012918 active site 527021012919 phosphorylation site [posttranslational modification] 527021012920 intermolecular recognition site; other site 527021012921 dimerization interface [polypeptide binding]; other site 527021012922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021012923 DNA binding site [nucleotide binding] 527021012924 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 527021012925 active site 2 [active] 527021012926 active site 1 [active] 527021012927 malate dehydrogenase; Reviewed; Region: PRK06223 527021012928 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 527021012929 NAD(P) binding site [chemical binding]; other site 527021012930 dimer interface [polypeptide binding]; other site 527021012931 tetramer (dimer of dimers) interface [polypeptide binding]; other site 527021012932 substrate binding site [chemical binding]; other site 527021012933 isocitrate dehydrogenase; Reviewed; Region: PRK07006 527021012934 isocitrate dehydrogenase; Validated; Region: PRK07362 527021012935 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 527021012936 dimer interface [polypeptide binding]; other site 527021012937 Citrate synthase; Region: Citrate_synt; pfam00285 527021012938 active site 527021012939 citrylCoA binding site [chemical binding]; other site 527021012940 oxalacetate/citrate binding site [chemical binding]; other site 527021012941 coenzyme A binding site [chemical binding]; other site 527021012942 catalytic triad [active] 527021012943 Protein of unknown function (DUF441); Region: DUF441; pfam04284 527021012944 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 527021012945 Domain of unknown function DUF20; Region: UPF0118; pfam01594 527021012946 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 527021012947 pyruvate kinase; Provisional; Region: PRK06354 527021012948 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 527021012949 domain interfaces; other site 527021012950 active site 527021012951 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 527021012952 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 527021012953 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 527021012954 active site 527021012955 ADP/pyrophosphate binding site [chemical binding]; other site 527021012956 dimerization interface [polypeptide binding]; other site 527021012957 allosteric effector site; other site 527021012958 fructose-1,6-bisphosphate binding site; other site 527021012959 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 527021012960 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 527021012961 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 527021012962 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 527021012963 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 527021012964 Transcriptional regulators [Transcription]; Region: FadR; COG2186 527021012965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021012966 DNA-binding site [nucleotide binding]; DNA binding site 527021012967 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 527021012968 Malic enzyme, N-terminal domain; Region: malic; pfam00390 527021012969 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 527021012970 putative NAD(P) binding site [chemical binding]; other site 527021012971 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 527021012972 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 527021012973 active site 527021012974 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 527021012975 generic binding surface II; other site 527021012976 generic binding surface I; other site 527021012977 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 527021012978 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 527021012979 DHH family; Region: DHH; pfam01368 527021012980 DHHA1 domain; Region: DHHA1; pfam02272 527021012981 YtpI-like protein; Region: YtpI; pfam14007 527021012982 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 527021012983 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 527021012984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021012985 DNA-binding site [nucleotide binding]; DNA binding site 527021012986 DRTGG domain; Region: DRTGG; pfam07085 527021012987 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 527021012988 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 527021012989 active site 2 [active] 527021012990 active site 1 [active] 527021012991 metal-dependent hydrolase; Provisional; Region: PRK00685 527021012992 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 527021012993 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 527021012994 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 527021012995 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 527021012996 active site 527021012997 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 527021012998 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 527021012999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021013000 Coenzyme A binding pocket [chemical binding]; other site 527021013001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021013002 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021013003 Coenzyme A binding pocket [chemical binding]; other site 527021013004 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 527021013005 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 527021013006 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 527021013007 hexamer interface [polypeptide binding]; other site 527021013008 ligand binding site [chemical binding]; other site 527021013009 putative active site [active] 527021013010 NAD(P) binding site [chemical binding]; other site 527021013011 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 527021013012 classical (c) SDRs; Region: SDR_c; cd05233 527021013013 NAD(P) binding site [chemical binding]; other site 527021013014 active site 527021013015 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 527021013016 Ligand Binding Site [chemical binding]; other site 527021013017 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 527021013018 argininosuccinate lyase; Provisional; Region: PRK00855 527021013019 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 527021013020 active sites [active] 527021013021 tetramer interface [polypeptide binding]; other site 527021013022 argininosuccinate synthase; Provisional; Region: PRK13820 527021013023 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 527021013024 ANP binding site [chemical binding]; other site 527021013025 Substrate Binding Site II [chemical binding]; other site 527021013026 Substrate Binding Site I [chemical binding]; other site 527021013027 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021013028 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021013029 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021013030 EcsC protein family; Region: EcsC; pfam12787 527021013031 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 527021013032 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 527021013033 nudix motif; other site 527021013034 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 527021013035 propionate/acetate kinase; Provisional; Region: PRK12379 527021013036 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 527021013037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021013038 S-adenosylmethionine binding site [chemical binding]; other site 527021013039 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 527021013040 dimer interface [polypeptide binding]; other site 527021013041 catalytic triad [active] 527021013042 peroxidatic and resolving cysteines [active] 527021013043 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 527021013044 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 527021013045 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 527021013046 ATP-NAD kinase; Region: NAD_kinase; pfam01513 527021013047 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 527021013048 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 527021013049 active site 527021013050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021013051 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 527021013052 dimer interface [polypeptide binding]; other site 527021013053 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 527021013054 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 527021013055 active site 527021013056 acyl-activating enzyme (AAE) consensus motif; other site 527021013057 putative CoA binding site [chemical binding]; other site 527021013058 AMP binding site [chemical binding]; other site 527021013059 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 527021013060 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 527021013061 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 527021013062 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 527021013063 Ligand Binding Site [chemical binding]; other site 527021013064 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 527021013065 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 527021013066 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021013067 catalytic residue [active] 527021013068 septation ring formation regulator EzrA; Provisional; Region: PRK04778 527021013069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021013070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021013071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 527021013072 dimerization interface [polypeptide binding]; other site 527021013073 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021013074 EamA-like transporter family; Region: EamA; pfam00892 527021013075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021013076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021013077 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 527021013078 GAF domain; Region: GAF_2; pfam13185 527021013079 methionine gamma-lyase; Provisional; Region: PRK06767 527021013080 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 527021013081 homodimer interface [polypeptide binding]; other site 527021013082 substrate-cofactor binding pocket; other site 527021013083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021013084 catalytic residue [active] 527021013085 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 527021013086 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 527021013087 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021013088 RNA binding surface [nucleotide binding]; other site 527021013089 Uncharacterized conserved protein [Function unknown]; Region: COG4748 527021013090 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 527021013091 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 527021013092 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 527021013093 active site 527021013094 HIGH motif; other site 527021013095 dimer interface [polypeptide binding]; other site 527021013096 KMSKS motif; other site 527021013097 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021013098 RNA binding surface [nucleotide binding]; other site 527021013099 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 527021013100 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021013101 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021013102 DNA binding residues [nucleotide binding] 527021013103 maltose O-acetyltransferase; Provisional; Region: PRK10092 527021013104 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 527021013105 active site 527021013106 substrate binding site [chemical binding]; other site 527021013107 trimer interface [polypeptide binding]; other site 527021013108 CoA binding site [chemical binding]; other site 527021013109 acetyl-CoA synthetase; Provisional; Region: PRK04319 527021013110 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 527021013111 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 527021013112 active site 527021013113 acyl-activating enzyme (AAE) consensus motif; other site 527021013114 putative CoA binding site [chemical binding]; other site 527021013115 AMP binding site [chemical binding]; other site 527021013116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021013117 Coenzyme A binding pocket [chemical binding]; other site 527021013118 FOG: CBS domain [General function prediction only]; Region: COG0517 527021013119 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 527021013120 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 527021013121 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 527021013122 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 527021013123 active site 527021013124 Zn binding site [ion binding]; other site 527021013125 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 527021013126 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021013127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021013128 active site 527021013129 phosphorylation site [posttranslational modification] 527021013130 intermolecular recognition site; other site 527021013131 dimerization interface [polypeptide binding]; other site 527021013132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021013133 DNA binding site [nucleotide binding] 527021013134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021013135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021013136 dimerization interface [polypeptide binding]; other site 527021013137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021013138 dimer interface [polypeptide binding]; other site 527021013139 phosphorylation site [posttranslational modification] 527021013140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021013141 ATP binding site [chemical binding]; other site 527021013142 Mg2+ binding site [ion binding]; other site 527021013143 G-X-G motif; other site 527021013144 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 527021013145 Ankyrin repeat; Region: Ank; pfam00023 527021013146 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 527021013147 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 527021013148 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 527021013149 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 527021013150 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 527021013151 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 527021013152 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 527021013153 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 527021013154 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 527021013155 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 527021013156 catabolite control protein A; Region: ccpA; TIGR01481 527021013157 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 527021013158 DNA binding site [nucleotide binding] 527021013159 domain linker motif; other site 527021013160 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 527021013161 dimerization interface [polypeptide binding]; other site 527021013162 effector binding site; other site 527021013163 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 527021013164 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 527021013165 putative dimer interface [polypeptide binding]; other site 527021013166 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 527021013167 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 527021013168 putative dimer interface [polypeptide binding]; other site 527021013169 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 527021013170 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 527021013171 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 527021013172 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 527021013173 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 527021013174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 527021013175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021013176 Coenzyme A binding pocket [chemical binding]; other site 527021013177 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 527021013178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021013179 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021013180 EamA-like transporter family; Region: EamA; pfam00892 527021013181 EamA-like transporter family; Region: EamA; pfam00892 527021013182 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 527021013183 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021013184 DNA binding residues [nucleotide binding] 527021013185 putative dimer interface [polypeptide binding]; other site 527021013186 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 527021013187 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 527021013188 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 527021013189 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 527021013190 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 527021013191 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 527021013192 active site 527021013193 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 527021013194 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 527021013195 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 527021013196 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 527021013197 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 527021013198 active site 527021013199 metal binding site [ion binding]; metal-binding site 527021013200 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 527021013201 putative tRNA-binding site [nucleotide binding]; other site 527021013202 hypothetical protein; Provisional; Region: PRK13668 527021013203 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 527021013204 catalytic residues [active] 527021013205 NTPase; Reviewed; Region: PRK03114 527021013206 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 527021013207 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 527021013208 oligomer interface [polypeptide binding]; other site 527021013209 active site 527021013210 metal binding site [ion binding]; metal-binding site 527021013211 Predicted small secreted protein [Function unknown]; Region: COG5584 527021013212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021013213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021013214 S-adenosylmethionine binding site [chemical binding]; other site 527021013215 YtzH-like protein; Region: YtzH; pfam14165 527021013216 Phosphotransferase enzyme family; Region: APH; pfam01636 527021013217 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 527021013218 active site 527021013219 substrate binding site [chemical binding]; other site 527021013220 ATP binding site [chemical binding]; other site 527021013221 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 527021013222 pullulanase, type I; Region: pulA_typeI; TIGR02104 527021013223 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 527021013224 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 527021013225 Ca binding site [ion binding]; other site 527021013226 active site 527021013227 catalytic site [active] 527021013228 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 527021013229 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 527021013230 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 527021013231 dipeptidase PepV; Reviewed; Region: PRK07318 527021013232 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 527021013233 active site 527021013234 metal binding site [ion binding]; metal-binding site 527021013235 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 527021013236 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 527021013237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021013238 RNA binding surface [nucleotide binding]; other site 527021013239 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 527021013240 active site 527021013241 uracil binding [chemical binding]; other site 527021013242 stage V sporulation protein B; Region: spore_V_B; TIGR02900 527021013243 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 527021013244 HI0933-like protein; Region: HI0933_like; pfam03486 527021013245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 527021013246 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 527021013247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021013248 putative substrate translocation pore; other site 527021013249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021013250 dimerization interface [polypeptide binding]; other site 527021013251 putative DNA binding site [nucleotide binding]; other site 527021013252 putative Zn2+ binding site [ion binding]; other site 527021013253 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 527021013254 putative hydrophobic ligand binding site [chemical binding]; other site 527021013255 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 527021013256 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 527021013257 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 527021013258 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 527021013259 glucose-1-dehydrogenase; Provisional; Region: PRK08936 527021013260 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 527021013261 NAD binding site [chemical binding]; other site 527021013262 homodimer interface [polypeptide binding]; other site 527021013263 active site 527021013264 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 527021013265 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 527021013266 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 527021013267 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 527021013268 MoaE interaction surface [polypeptide binding]; other site 527021013269 MoeB interaction surface [polypeptide binding]; other site 527021013270 thiocarboxylated glycine; other site 527021013271 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 527021013272 MoaE homodimer interface [polypeptide binding]; other site 527021013273 MoaD interaction [polypeptide binding]; other site 527021013274 active site residues [active] 527021013275 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 527021013276 Walker A motif; other site 527021013277 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 527021013278 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 527021013279 dimer interface [polypeptide binding]; other site 527021013280 putative functional site; other site 527021013281 putative MPT binding site; other site 527021013282 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 527021013283 trimer interface [polypeptide binding]; other site 527021013284 dimer interface [polypeptide binding]; other site 527021013285 putative active site [active] 527021013286 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 527021013287 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 527021013288 ATP binding site [chemical binding]; other site 527021013289 substrate interface [chemical binding]; other site 527021013290 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 527021013291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021013292 FeS/SAM binding site; other site 527021013293 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 527021013294 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 527021013295 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 527021013296 active site residue [active] 527021013297 homoserine O-acetyltransferase; Provisional; Region: PRK06765 527021013298 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 527021013299 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 527021013300 Spore germination protein; Region: Spore_permease; pfam03845 527021013301 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 527021013302 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 527021013303 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 527021013304 putative nucleotide binding site [chemical binding]; other site 527021013305 putative metal binding site [ion binding]; other site 527021013306 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 527021013307 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 527021013308 HIGH motif; other site 527021013309 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 527021013310 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 527021013311 active site 527021013312 KMSKS motif; other site 527021013313 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 527021013314 tRNA binding surface [nucleotide binding]; other site 527021013315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021013316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021013317 putative substrate translocation pore; other site 527021013318 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 527021013319 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 527021013320 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 527021013321 TrkA-C domain; Region: TrkA_C; pfam02080 527021013322 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 527021013323 Int/Topo IB signature motif; other site 527021013324 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 527021013325 FtsX-like permease family; Region: FtsX; pfam02687 527021013326 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021013327 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021013328 Walker A/P-loop; other site 527021013329 ATP binding site [chemical binding]; other site 527021013330 Q-loop/lid; other site 527021013331 ABC transporter signature motif; other site 527021013332 Walker B; other site 527021013333 D-loop; other site 527021013334 H-loop/switch region; other site 527021013335 Predicted membrane protein [Function unknown]; Region: COG2311 527021013336 Protein of unknown function (DUF418); Region: DUF418; cl12135 527021013337 Protein of unknown function (DUF418); Region: DUF418; pfam04235 527021013338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 527021013339 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 527021013340 Probable transposase; Region: OrfB_IS605; pfam01385 527021013341 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 527021013342 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 527021013343 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 527021013344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021013345 FeS/SAM binding site; other site 527021013346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021013347 S-adenosylmethionine binding site [chemical binding]; other site 527021013348 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 527021013349 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021013350 Walker A/P-loop; other site 527021013351 ATP binding site [chemical binding]; other site 527021013352 Q-loop/lid; other site 527021013353 ABC transporter signature motif; other site 527021013354 Walker B; other site 527021013355 D-loop; other site 527021013356 H-loop/switch region; other site 527021013357 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 527021013358 aspartate racemase; Region: asp_race; TIGR00035 527021013359 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 527021013360 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 527021013361 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 527021013362 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 527021013363 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 527021013364 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021013365 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 527021013366 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 527021013367 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 527021013368 trimer interface [polypeptide binding]; other site 527021013369 putative metal binding site [ion binding]; other site 527021013370 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 527021013371 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 527021013372 active site 527021013373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 527021013374 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 527021013375 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 527021013376 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 527021013377 GTP binding site; other site 527021013378 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 527021013379 MPT binding site; other site 527021013380 trimer interface [polypeptide binding]; other site 527021013381 S-adenosylmethionine synthetase; Validated; Region: PRK05250 527021013382 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 527021013383 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 527021013384 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 527021013385 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 527021013386 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 527021013387 active site 527021013388 substrate-binding site [chemical binding]; other site 527021013389 metal-binding site [ion binding] 527021013390 ATP binding site [chemical binding]; other site 527021013391 ATP synthase I chain; Region: ATP_synt_I; pfam03899 527021013392 EamA-like transporter family; Region: EamA; pfam00892 527021013393 EamA-like transporter family; Region: EamA; pfam00892 527021013394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 527021013395 Uncharacterized conserved protein [Function unknown]; Region: COG0327 527021013396 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 527021013397 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 527021013398 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 527021013399 WxL domain surface cell wall-binding; Region: WxL; pfam13731 527021013400 WxL domain surface cell wall-binding; Region: WxL; pfam13731 527021013401 WxL domain surface cell wall-binding; Region: WxL; pfam13731 527021013402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021013403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021013404 ATP binding site [chemical binding]; other site 527021013405 Mg2+ binding site [ion binding]; other site 527021013406 G-X-G motif; other site 527021013407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021013408 dimer interface [polypeptide binding]; other site 527021013409 phosphorylation site [posttranslational modification] 527021013410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021013411 ATP binding site [chemical binding]; other site 527021013412 Mg2+ binding site [ion binding]; other site 527021013413 G-X-G motif; other site 527021013414 hydroperoxidase II; Provisional; Region: katE; PRK11249 527021013415 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 527021013416 heme binding pocket [chemical binding]; other site 527021013417 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 527021013418 domain interactions; other site 527021013419 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 527021013420 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 527021013421 TAP-like protein; Region: Abhydrolase_4; pfam08386 527021013422 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 527021013423 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 527021013424 TM-ABC transporter signature motif; other site 527021013425 Sulfatase; Region: Sulfatase; pfam00884 527021013426 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 527021013427 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 527021013428 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 527021013429 NMT1-like family; Region: NMT1_2; pfam13379 527021013430 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 527021013431 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 527021013432 Walker A/P-loop; other site 527021013433 ATP binding site [chemical binding]; other site 527021013434 Q-loop/lid; other site 527021013435 ABC transporter signature motif; other site 527021013436 Walker B; other site 527021013437 D-loop; other site 527021013438 H-loop/switch region; other site 527021013439 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 527021013440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021013441 dimer interface [polypeptide binding]; other site 527021013442 conserved gate region; other site 527021013443 putative PBP binding loops; other site 527021013444 ABC-ATPase subunit interface; other site 527021013445 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 527021013446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021013447 motif II; other site 527021013448 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 527021013449 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 527021013450 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 527021013451 nudix motif; other site 527021013452 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 527021013453 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 527021013454 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 527021013455 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 527021013456 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 527021013457 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021013458 DNA binding residues [nucleotide binding] 527021013459 dimer interface [polypeptide binding]; other site 527021013460 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 527021013461 S-ribosylhomocysteinase; Provisional; Region: PRK02260 527021013462 Haemolytic domain; Region: Haemolytic; pfam01809 527021013463 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 527021013464 active site clefts [active] 527021013465 zinc binding site [ion binding]; other site 527021013466 dimer interface [polypeptide binding]; other site 527021013467 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 527021013468 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 527021013469 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 527021013470 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 527021013471 Uncharacterized conserved protein [Function unknown]; Region: COG1434 527021013472 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 527021013473 putative active site [active] 527021013474 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021013475 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021013476 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021013477 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021013478 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 527021013479 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 527021013480 Predicted membrane protein [Function unknown]; Region: COG3766 527021013481 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 527021013482 hypothetical protein; Provisional; Region: PRK12473 527021013483 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 527021013484 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 527021013485 G1 box; other site 527021013486 GTP/Mg2+ binding site [chemical binding]; other site 527021013487 Switch I region; other site 527021013488 G2 box; other site 527021013489 G3 box; other site 527021013490 Switch II region; other site 527021013491 G4 box; other site 527021013492 G5 box; other site 527021013493 Nucleoside recognition; Region: Gate; pfam07670 527021013494 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 527021013495 Nucleoside recognition; Region: Gate; pfam07670 527021013496 FeoA domain; Region: FeoA; pfam04023 527021013497 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 527021013498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021013499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021013500 dimerization interface [polypeptide binding]; other site 527021013501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021013502 dimer interface [polypeptide binding]; other site 527021013503 phosphorylation site [posttranslational modification] 527021013504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021013505 ATP binding site [chemical binding]; other site 527021013506 Mg2+ binding site [ion binding]; other site 527021013507 G-X-G motif; other site 527021013508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021013509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021013510 active site 527021013511 phosphorylation site [posttranslational modification] 527021013512 intermolecular recognition site; other site 527021013513 dimerization interface [polypeptide binding]; other site 527021013514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021013515 DNA binding site [nucleotide binding] 527021013516 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 527021013517 active site 527021013518 catalytic site [active] 527021013519 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021013520 active site 527021013521 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 527021013522 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 527021013523 Cold-inducible protein YdjO; Region: YdjO; pfam14169 527021013524 FtsX-like permease family; Region: FtsX; pfam02687 527021013525 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021013526 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021013527 Walker A/P-loop; other site 527021013528 ATP binding site [chemical binding]; other site 527021013529 Q-loop/lid; other site 527021013530 ABC transporter signature motif; other site 527021013531 Walker B; other site 527021013532 D-loop; other site 527021013533 H-loop/switch region; other site 527021013534 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 527021013535 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 527021013536 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 527021013537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021013538 S-adenosylmethionine binding site [chemical binding]; other site 527021013539 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 527021013540 FtsX-like permease family; Region: FtsX; pfam02687 527021013541 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021013542 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021013543 Walker A/P-loop; other site 527021013544 ATP binding site [chemical binding]; other site 527021013545 Q-loop/lid; other site 527021013546 ABC transporter signature motif; other site 527021013547 Walker B; other site 527021013548 D-loop; other site 527021013549 H-loop/switch region; other site 527021013550 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 527021013551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 527021013552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 527021013553 SdpI/YhfL protein family; Region: SdpI; pfam13630 527021013554 Predicted integral membrane protein [Function unknown]; Region: COG5658 527021013555 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 527021013556 SdpI/YhfL protein family; Region: SdpI; pfam13630 527021013557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021013558 dimerization interface [polypeptide binding]; other site 527021013559 putative DNA binding site [nucleotide binding]; other site 527021013560 putative Zn2+ binding site [ion binding]; other site 527021013561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021013562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021013563 active site 527021013564 phosphorylation site [posttranslational modification] 527021013565 intermolecular recognition site; other site 527021013566 dimerization interface [polypeptide binding]; other site 527021013567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021013568 DNA binding site [nucleotide binding] 527021013569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021013570 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 527021013571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021013572 ATP binding site [chemical binding]; other site 527021013573 Mg2+ binding site [ion binding]; other site 527021013574 G-X-G motif; other site 527021013575 FtsX-like permease family; Region: FtsX; pfam02687 527021013576 FtsX-like permease family; Region: FtsX; pfam02687 527021013577 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021013578 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021013579 Walker A/P-loop; other site 527021013580 ATP binding site [chemical binding]; other site 527021013581 Q-loop/lid; other site 527021013582 ABC transporter signature motif; other site 527021013583 Walker B; other site 527021013584 D-loop; other site 527021013585 H-loop/switch region; other site 527021013586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021013587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021013588 GntP family permease; Region: GntP_permease; pfam02447 527021013589 fructuronate transporter; Provisional; Region: PRK10034; cl15264 527021013590 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 527021013591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 527021013592 DNA-binding site [nucleotide binding]; DNA binding site 527021013593 UTRA domain; Region: UTRA; pfam07702 527021013594 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 527021013595 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 527021013596 substrate binding site [chemical binding]; other site 527021013597 ATP binding site [chemical binding]; other site 527021013598 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 527021013599 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 527021013600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021013601 catalytic residue [active] 527021013602 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 527021013603 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 527021013604 active site 527021013605 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 527021013606 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 527021013607 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 527021013608 dimerization interface [polypeptide binding]; other site 527021013609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021013610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021013611 dimer interface [polypeptide binding]; other site 527021013612 phosphorylation site [posttranslational modification] 527021013613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021013614 ATP binding site [chemical binding]; other site 527021013615 Mg2+ binding site [ion binding]; other site 527021013616 G-X-G motif; other site 527021013617 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021013618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021013619 active site 527021013620 phosphorylation site [posttranslational modification] 527021013621 intermolecular recognition site; other site 527021013622 dimerization interface [polypeptide binding]; other site 527021013623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021013624 DNA binding site [nucleotide binding] 527021013625 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 527021013626 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 527021013627 active site 527021013628 octamer interface [polypeptide binding]; other site 527021013629 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 527021013630 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 527021013631 acyl-activating enzyme (AAE) consensus motif; other site 527021013632 putative AMP binding site [chemical binding]; other site 527021013633 putative active site [active] 527021013634 putative CoA binding site [chemical binding]; other site 527021013635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 527021013636 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 527021013637 substrate binding site [chemical binding]; other site 527021013638 oxyanion hole (OAH) forming residues; other site 527021013639 trimer interface [polypeptide binding]; other site 527021013640 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 527021013641 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 527021013642 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 527021013643 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 527021013644 dimer interface [polypeptide binding]; other site 527021013645 tetramer interface [polypeptide binding]; other site 527021013646 PYR/PP interface [polypeptide binding]; other site 527021013647 TPP binding site [chemical binding]; other site 527021013648 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 527021013649 TPP-binding site; other site 527021013650 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 527021013651 chorismate binding enzyme; Region: Chorismate_bind; cl10555 527021013652 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 527021013653 UbiA prenyltransferase family; Region: UbiA; pfam01040 527021013654 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 527021013655 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 527021013656 DNA-binding site [nucleotide binding]; DNA binding site 527021013657 RNA-binding motif; other site 527021013658 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 527021013659 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 527021013660 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021013661 DNA binding residues [nucleotide binding] 527021013662 dimer interface [polypeptide binding]; other site 527021013663 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 527021013664 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 527021013665 active site flap/lid [active] 527021013666 nucleophilic elbow; other site 527021013667 catalytic triad [active] 527021013668 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 527021013669 homodimer interface [polypeptide binding]; other site 527021013670 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 527021013671 active site pocket [active] 527021013672 glycogen synthase; Provisional; Region: glgA; PRK00654 527021013673 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 527021013674 ADP-binding pocket [chemical binding]; other site 527021013675 homodimer interface [polypeptide binding]; other site 527021013676 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 527021013677 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 527021013678 ligand binding site; other site 527021013679 oligomer interface; other site 527021013680 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 527021013681 dimer interface [polypeptide binding]; other site 527021013682 N-terminal domain interface [polypeptide binding]; other site 527021013683 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 527021013684 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 527021013685 ligand binding site; other site 527021013686 oligomer interface; other site 527021013687 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 527021013688 dimer interface [polypeptide binding]; other site 527021013689 N-terminal domain interface [polypeptide binding]; other site 527021013690 sulfate 1 binding site; other site 527021013691 glycogen branching enzyme; Provisional; Region: PRK12313 527021013692 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 527021013693 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 527021013694 active site 527021013695 catalytic site [active] 527021013696 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 527021013697 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 527021013698 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 527021013699 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 527021013700 putative active site [active] 527021013701 catalytic triad [active] 527021013702 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 527021013703 PA/protease domain interface [polypeptide binding]; other site 527021013704 putative integrin binding motif; other site 527021013705 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 527021013706 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 527021013707 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 527021013708 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 527021013709 tetramer (dimer of dimers) interface [polypeptide binding]; other site 527021013710 NAD binding site [chemical binding]; other site 527021013711 dimer interface [polypeptide binding]; other site 527021013712 substrate binding site [chemical binding]; other site 527021013713 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 527021013714 MgtC family; Region: MgtC; pfam02308 527021013715 Ion channel; Region: Ion_trans_2; pfam07885 527021013716 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 527021013717 TrkA-N domain; Region: TrkA_N; pfam02254 527021013718 YugN-like family; Region: YugN; pfam08868 527021013719 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 527021013720 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 527021013721 active site 527021013722 dimer interface [polypeptide binding]; other site 527021013723 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 527021013724 dimer interface [polypeptide binding]; other site 527021013725 active site 527021013726 Domain of unknown function (DUF378); Region: DUF378; pfam04070 527021013727 general stress protein 13; Validated; Region: PRK08059 527021013728 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 527021013729 RNA binding site [nucleotide binding]; other site 527021013730 hypothetical protein; Validated; Region: PRK07682 527021013731 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021013732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021013733 homodimer interface [polypeptide binding]; other site 527021013734 catalytic residue [active] 527021013735 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 527021013736 AsnC family; Region: AsnC_trans_reg; pfam01037 527021013737 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 527021013738 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 527021013739 dimerization interface [polypeptide binding]; other site 527021013740 ligand binding site [chemical binding]; other site 527021013741 NADP binding site [chemical binding]; other site 527021013742 catalytic site [active] 527021013743 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 527021013744 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 527021013745 nucleophilic elbow; other site 527021013746 catalytic triad; other site 527021013747 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 527021013748 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 527021013749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 527021013750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021013751 homodimer interface [polypeptide binding]; other site 527021013752 catalytic residue [active] 527021013753 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 527021013754 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 527021013755 E-class dimer interface [polypeptide binding]; other site 527021013756 P-class dimer interface [polypeptide binding]; other site 527021013757 active site 527021013758 Cu2+ binding site [ion binding]; other site 527021013759 Zn2+ binding site [ion binding]; other site 527021013760 Kinase associated protein B; Region: KapB; pfam08810 527021013761 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 527021013762 active site 527021013763 catalytic site [active] 527021013764 substrate binding site [chemical binding]; other site 527021013765 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 527021013766 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 527021013767 transmembrane helices; other site 527021013768 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 527021013769 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 527021013770 active site 527021013771 glycyl-tRNA synthetase; Provisional; Region: PRK04173 527021013772 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 527021013773 motif 1; other site 527021013774 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 527021013775 active site 527021013776 motif 2; other site 527021013777 motif 3; other site 527021013778 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 527021013779 anticodon binding site; other site 527021013780 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 527021013781 CoenzymeA binding site [chemical binding]; other site 527021013782 subunit interaction site [polypeptide binding]; other site 527021013783 PHB binding site; other site 527021013784 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 527021013785 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 527021013786 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 527021013787 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 527021013788 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 527021013789 active site 527021013790 tetramer interface; other site 527021013791 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 527021013792 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 527021013793 active site 527021013794 substrate binding site [chemical binding]; other site 527021013795 metal binding site [ion binding]; metal-binding site 527021013796 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 527021013797 Uncharacterized conserved protein [Function unknown]; Region: COG1624 527021013798 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 527021013799 Divergent PAP2 family; Region: DUF212; cl00855 527021013800 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 527021013801 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 527021013802 multifunctional aminopeptidase A; Provisional; Region: PRK00913 527021013803 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 527021013804 interface (dimer of trimers) [polypeptide binding]; other site 527021013805 Substrate-binding/catalytic site; other site 527021013806 Zn-binding sites [ion binding]; other site 527021013807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 527021013808 Putative membrane protein; Region: YuiB; pfam14068 527021013809 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 527021013810 nudix motif; other site 527021013811 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 527021013812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021013813 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 527021013814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 527021013815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021013816 Domain of unknown function DUF11; Region: DUF11; pfam01345 527021013817 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021013818 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 527021013819 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021013820 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021013821 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021013822 Domain of unknown function DUF11; Region: DUF11; cl17728 527021013823 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021013824 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021013825 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021013826 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021013827 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021013828 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 527021013829 Domain of unknown function DUF11; Region: DUF11; pfam01345 527021013830 Domain of unknown function DUF11; Region: DUF11; pfam01345 527021013831 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021013832 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021013833 conserved repeat domain; Region: B_ant_repeat; TIGR01451 527021013834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 527021013835 H+ Antiporter protein; Region: 2A0121; TIGR00900 527021013836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021013837 putative substrate translocation pore; other site 527021013838 Helix-turn-helix domain; Region: HTH_36; pfam13730 527021013839 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 527021013840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 527021013841 putative DNA binding site [nucleotide binding]; other site 527021013842 dimerization interface [polypeptide binding]; other site 527021013843 Protein of unknown function (DUF523); Region: DUF523; pfam04463 527021013844 Helix-turn-helix domain; Region: HTH_36; pfam13730 527021013845 Replication-relaxation; Region: Replic_Relax; pfam13814 527021013846 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 527021013847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021013848 non-specific DNA binding site [nucleotide binding]; other site 527021013849 salt bridge; other site 527021013850 sequence-specific DNA binding site [nucleotide binding]; other site 527021013851 hypothetical protein; Region: PHA02436 527021013852 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 527021013853 amidase catalytic site [active] 527021013854 Zn binding residues [ion binding]; other site 527021013855 substrate binding site [chemical binding]; other site 527021013856 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021013857 Holin family; Region: Phage_holin_4; pfam05105 527021013858 Haemolysin XhlA; Region: XhlA; pfam10779 527021013859 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 527021013860 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 527021013861 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 527021013862 Phage tail protein; Region: Sipho_tail; cl17486 527021013863 Phage-related minor tail protein [Function unknown]; Region: COG5280 527021013864 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 527021013865 membrane protein P6; Region: PHA01399 527021013866 Phage-related protein [Function unknown]; Region: COG5412 527021013867 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 527021013868 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 527021013869 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 527021013870 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 527021013871 Phage capsid family; Region: Phage_capsid; pfam05065 527021013872 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 527021013873 Phage portal protein; Region: Phage_portal; pfam04860 527021013874 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 527021013875 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 527021013876 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 527021013877 active site 527021013878 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 527021013879 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 527021013880 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021013881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021013882 Walker A motif; other site 527021013883 ATP binding site [chemical binding]; other site 527021013884 Walker B motif; other site 527021013885 arginine finger; other site 527021013886 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 527021013887 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 527021013888 ORF6C domain; Region: ORF6C; pfam10552 527021013889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021013890 non-specific DNA binding site [nucleotide binding]; other site 527021013891 salt bridge; other site 527021013892 sequence-specific DNA binding site [nucleotide binding]; other site 527021013893 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021013894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021013895 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021013896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021013897 non-specific DNA binding site [nucleotide binding]; other site 527021013898 salt bridge; other site 527021013899 sequence-specific DNA binding site [nucleotide binding]; other site 527021013900 integrase; Provisional; Region: int; PHA02601 527021013901 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 527021013902 Int/Topo IB signature motif; other site 527021013903 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 527021013904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 527021013905 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 527021013906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021013907 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 527021013908 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 527021013909 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 527021013910 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 527021013911 hypothetical protein; Provisional; Region: PRK13669 527021013912 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 527021013913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021013914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021013915 Walker A/P-loop; other site 527021013916 ATP binding site [chemical binding]; other site 527021013917 ABC transporter; Region: ABC_tran; pfam00005 527021013918 Q-loop/lid; other site 527021013919 ABC transporter signature motif; other site 527021013920 Walker B; other site 527021013921 D-loop; other site 527021013922 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 527021013923 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 527021013924 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 527021013925 PhnA protein; Region: PhnA; pfam03831 527021013926 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 527021013927 CAAX protease self-immunity; Region: Abi; pfam02517 527021013928 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 527021013929 active site 527021013930 NTP binding site [chemical binding]; other site 527021013931 metal binding triad [ion binding]; metal-binding site 527021013932 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 527021013933 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 527021013934 NifU-like domain; Region: NifU; pfam01106 527021013935 spore coat protein YutH; Region: spore_yutH; TIGR02905 527021013936 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 527021013937 tetramer interfaces [polypeptide binding]; other site 527021013938 binuclear metal-binding site [ion binding]; other site 527021013939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021013940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021013941 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 527021013942 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021013943 active site 527021013944 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 527021013945 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 527021013946 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 527021013947 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 527021013948 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 527021013949 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 527021013950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021013951 active site 527021013952 motif I; other site 527021013953 motif II; other site 527021013954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021013955 Predicted transcriptional regulator [Transcription]; Region: COG2345 527021013956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021013957 putative Zn2+ binding site [ion binding]; other site 527021013958 putative DNA binding site [nucleotide binding]; other site 527021013959 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 527021013960 Uncharacterized conserved protein [Function unknown]; Region: COG2445 527021013961 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 527021013962 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 527021013963 putative active site [active] 527021013964 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 527021013965 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 527021013966 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021013967 RNA binding surface [nucleotide binding]; other site 527021013968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021013969 Coenzyme A binding pocket [chemical binding]; other site 527021013970 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 527021013971 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 527021013972 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 527021013973 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 527021013974 DNA binding residues [nucleotide binding] 527021013975 dimer interface [polypeptide binding]; other site 527021013976 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 527021013977 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 527021013978 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 527021013979 catalytic core [active] 527021013980 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 527021013981 putative deacylase active site [active] 527021013982 lipoyl synthase; Provisional; Region: PRK05481 527021013983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021013984 FeS/SAM binding site; other site 527021013985 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 527021013986 Peptidase family M23; Region: Peptidase_M23; pfam01551 527021013987 sporulation protein YunB; Region: spo_yunB; TIGR02832 527021013988 Uncharacterized conserved protein [Function unknown]; Region: COG3377 527021013989 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 527021013990 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 527021013991 active site 527021013992 metal binding site [ion binding]; metal-binding site 527021013993 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 527021013994 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 527021013995 FeS assembly protein SufB; Region: sufB; TIGR01980 527021013996 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 527021013997 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 527021013998 trimerization site [polypeptide binding]; other site 527021013999 active site 527021014000 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 527021014001 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 527021014002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 527021014003 catalytic residue [active] 527021014004 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 527021014005 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 527021014006 FeS assembly protein SufD; Region: sufD; TIGR01981 527021014007 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 527021014008 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 527021014009 Walker A/P-loop; other site 527021014010 ATP binding site [chemical binding]; other site 527021014011 Q-loop/lid; other site 527021014012 ABC transporter signature motif; other site 527021014013 Walker B; other site 527021014014 D-loop; other site 527021014015 H-loop/switch region; other site 527021014016 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 527021014017 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 527021014018 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 527021014019 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 527021014020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 527021014021 ABC-ATPase subunit interface; other site 527021014022 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 527021014023 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 527021014024 Walker A/P-loop; other site 527021014025 ATP binding site [chemical binding]; other site 527021014026 Q-loop/lid; other site 527021014027 ABC transporter signature motif; other site 527021014028 Walker B; other site 527021014029 D-loop; other site 527021014030 H-loop/switch region; other site 527021014031 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 527021014032 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 527021014033 catalytic residues [active] 527021014034 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 527021014035 putative active site [active] 527021014036 putative metal binding site [ion binding]; other site 527021014037 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 527021014038 lipoyl attachment site [posttranslational modification]; other site 527021014039 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 527021014040 ArsC family; Region: ArsC; pfam03960 527021014041 putative ArsC-like catalytic residues; other site 527021014042 putative TRX-like catalytic residues [active] 527021014043 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 527021014044 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 527021014045 active site 527021014046 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 527021014047 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 527021014048 tetramer (dimer of dimers) interface [polypeptide binding]; other site 527021014049 NAD binding site [chemical binding]; other site 527021014050 dimer interface [polypeptide binding]; other site 527021014051 substrate binding site [chemical binding]; other site 527021014052 Coat F domain; Region: Coat_F; pfam07875 527021014053 CAAX protease self-immunity; Region: Abi; pfam02517 527021014054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021014055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021014056 WHG domain; Region: WHG; pfam13305 527021014057 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 527021014058 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 527021014059 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 527021014060 active site 527021014061 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 527021014062 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 527021014063 dimer interface [polypeptide binding]; other site 527021014064 active site 527021014065 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 527021014066 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 527021014067 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 527021014068 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 527021014069 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 527021014070 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 527021014071 substrate binding site [chemical binding]; other site 527021014072 oxyanion hole (OAH) forming residues; other site 527021014073 YuzL-like protein; Region: YuzL; pfam14115 527021014074 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021014075 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 527021014076 Proline dehydrogenase; Region: Pro_dh; cl03282 527021014077 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 527021014078 Domain of unknown function DUF77; Region: DUF77; pfam01910 527021014079 Cache domain; Region: Cache_1; pfam02743 527021014080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021014081 dimerization interface [polypeptide binding]; other site 527021014082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021014083 dimer interface [polypeptide binding]; other site 527021014084 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021014085 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021014086 dimer interface [polypeptide binding]; other site 527021014087 putative CheW interface [polypeptide binding]; other site 527021014088 Predicted transcriptional regulators [Transcription]; Region: COG1378 527021014089 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 527021014090 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 527021014091 C-terminal domain interface [polypeptide binding]; other site 527021014092 sugar binding site [chemical binding]; other site 527021014093 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 527021014094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021014095 putative substrate translocation pore; other site 527021014096 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 527021014097 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 527021014098 OxaA-like protein precursor; Validated; Region: PRK01622 527021014099 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021014100 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021014101 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021014102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 527021014103 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021014104 hypothetical protein; Provisional; Region: PRK06758 527021014105 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 527021014106 active site 527021014107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021014108 non-specific DNA binding site [nucleotide binding]; other site 527021014109 salt bridge; other site 527021014110 sequence-specific DNA binding site [nucleotide binding]; other site 527021014111 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 527021014112 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 527021014113 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 527021014114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 527021014115 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 527021014116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021014117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021014118 active site 527021014119 phosphorylation site [posttranslational modification] 527021014120 intermolecular recognition site; other site 527021014121 dimerization interface [polypeptide binding]; other site 527021014122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021014123 DNA binding site [nucleotide binding] 527021014124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 527021014125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021014126 dimer interface [polypeptide binding]; other site 527021014127 phosphorylation site [posttranslational modification] 527021014128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021014129 ATP binding site [chemical binding]; other site 527021014130 Mg2+ binding site [ion binding]; other site 527021014131 G-X-G motif; other site 527021014132 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 527021014133 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 527021014134 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 527021014135 active site 527021014136 HIGH motif; other site 527021014137 KMSKS motif; other site 527021014138 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 527021014139 tRNA binding surface [nucleotide binding]; other site 527021014140 anticodon binding site; other site 527021014141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021014142 S-adenosylmethionine binding site [chemical binding]; other site 527021014143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021014144 dimerization interface [polypeptide binding]; other site 527021014145 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021014146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021014147 dimer interface [polypeptide binding]; other site 527021014148 putative CheW interface [polypeptide binding]; other site 527021014149 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 527021014150 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021014151 dimerization interface [polypeptide binding]; other site 527021014152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021014153 dimer interface [polypeptide binding]; other site 527021014154 putative CheW interface [polypeptide binding]; other site 527021014155 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 527021014156 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 527021014157 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 527021014158 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 527021014159 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 527021014160 active site 527021014161 Zn binding site [ion binding]; other site 527021014162 Pirin-related protein [General function prediction only]; Region: COG1741 527021014163 Pirin; Region: Pirin; pfam02678 527021014164 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 527021014165 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 527021014166 MarR family; Region: MarR_2; pfam12802 527021014167 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 527021014168 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 527021014169 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 527021014170 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 527021014171 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 527021014172 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 527021014173 TrkA-C domain; Region: TrkA_C; pfam02080 527021014174 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 527021014175 amino acid carrier protein; Region: agcS; TIGR00835 527021014176 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 527021014177 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 527021014178 dimerization interface [polypeptide binding]; other site 527021014179 DPS ferroxidase diiron center [ion binding]; other site 527021014180 ion pore; other site 527021014181 DinB family; Region: DinB; cl17821 527021014182 DinB superfamily; Region: DinB_2; pfam12867 527021014183 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 527021014184 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 527021014185 metal binding site [ion binding]; metal-binding site 527021014186 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 527021014187 Ferritin-like domain; Region: Ferritin; pfam00210 527021014188 ferroxidase diiron center [ion binding]; other site 527021014189 Predicted membrane protein [Function unknown]; Region: COG2311 527021014190 Protein of unknown function (DUF418); Region: DUF418; cl12135 527021014191 Protein of unknown function (DUF418); Region: DUF418; pfam04235 527021014192 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 527021014193 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 527021014194 Nucleoside recognition; Region: Gate; pfam07670 527021014195 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 527021014196 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 527021014197 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 527021014198 Nucleoside recognition; Region: Gate; pfam07670 527021014199 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 527021014200 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 527021014201 amino acid carrier protein; Region: agcS; TIGR00835 527021014202 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 527021014203 amino acid carrier protein; Region: agcS; TIGR00835 527021014204 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 527021014205 NADH(P)-binding; Region: NAD_binding_10; pfam13460 527021014206 NAD binding site [chemical binding]; other site 527021014207 substrate binding site [chemical binding]; other site 527021014208 putative active site [active] 527021014209 Peptidase M60-like family; Region: M60-like; pfam13402 527021014210 Viral enhancin protein; Region: Enhancin; pfam03272 527021014211 TQXA domain; Region: TQXA_dom; TIGR03934 527021014212 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 527021014213 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 527021014214 active site 527021014215 catalytic tetrad [active] 527021014216 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 527021014217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021014218 putative substrate translocation pore; other site 527021014219 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021014220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021014221 dimerization interface [polypeptide binding]; other site 527021014222 putative DNA binding site [nucleotide binding]; other site 527021014223 putative Zn2+ binding site [ion binding]; other site 527021014224 Uncharacterized conserved protein [Function unknown]; Region: COG2427 527021014225 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 527021014226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021014227 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 527021014228 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 527021014229 active site 527021014230 HIGH motif; other site 527021014231 dimer interface [polypeptide binding]; other site 527021014232 KMSKS motif; other site 527021014233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 527021014234 RNA binding surface [nucleotide binding]; other site 527021014235 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 527021014236 FAD binding domain; Region: FAD_binding_4; pfam01565 527021014237 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 527021014238 SET domain; Region: SET; pfam00856 527021014239 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 527021014240 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021014241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021014242 dimer interface [polypeptide binding]; other site 527021014243 putative CheW interface [polypeptide binding]; other site 527021014244 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 527021014245 putative phosphate binding site [ion binding]; other site 527021014246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 527021014247 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 527021014248 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 527021014249 camphor resistance protein CrcB; Provisional; Region: PRK14219 527021014250 camphor resistance protein CrcB; Provisional; Region: PRK14205 527021014251 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 527021014252 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 527021014253 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 527021014254 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 527021014255 Coenzyme A binding pocket [chemical binding]; other site 527021014256 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 527021014257 Nuclease-related domain; Region: NERD; pfam08378 527021014258 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 527021014259 Isochorismatase family; Region: Isochorismatase; pfam00857 527021014260 catalytic triad [active] 527021014261 conserved cis-peptide bond; other site 527021014262 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 527021014263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021014264 putative DNA binding site [nucleotide binding]; other site 527021014265 putative Zn2+ binding site [ion binding]; other site 527021014266 AsnC family; Region: AsnC_trans_reg; pfam01037 527021014267 MarR family; Region: MarR_2; pfam12802 527021014268 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 527021014269 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 527021014270 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 527021014271 Walker A/P-loop; other site 527021014272 ATP binding site [chemical binding]; other site 527021014273 Q-loop/lid; other site 527021014274 ABC transporter signature motif; other site 527021014275 Walker B; other site 527021014276 D-loop; other site 527021014277 H-loop/switch region; other site 527021014278 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021014279 ABC-ATPase subunit interface; other site 527021014280 dimer interface [polypeptide binding]; other site 527021014281 putative PBP binding regions; other site 527021014282 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 527021014283 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021014284 ABC-ATPase subunit interface; other site 527021014285 dimer interface [polypeptide binding]; other site 527021014286 putative PBP binding regions; other site 527021014287 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 527021014288 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 527021014289 putative ligand binding residues [chemical binding]; other site 527021014290 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021014291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021014292 active site 527021014293 phosphorylation site [posttranslational modification] 527021014294 intermolecular recognition site; other site 527021014295 dimerization interface [polypeptide binding]; other site 527021014296 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021014297 DNA binding site [nucleotide binding] 527021014298 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 527021014299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021014300 Coenzyme A binding pocket [chemical binding]; other site 527021014301 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 527021014302 SmpB-tmRNA interface; other site 527021014303 ribonuclease R; Region: RNase_R; TIGR02063 527021014304 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 527021014305 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 527021014306 RNB domain; Region: RNB; pfam00773 527021014307 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 527021014308 RNA binding site [nucleotide binding]; other site 527021014309 Esterase/lipase [General function prediction only]; Region: COG1647 527021014310 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 527021014311 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 527021014312 holin-like protein; Validated; Region: PRK01658 527021014313 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 527021014314 active site 527021014315 enolase; Provisional; Region: eno; PRK00077 527021014316 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 527021014317 dimer interface [polypeptide binding]; other site 527021014318 metal binding site [ion binding]; metal-binding site 527021014319 substrate binding pocket [chemical binding]; other site 527021014320 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 527021014321 phosphoglyceromutase; Provisional; Region: PRK05434 527021014322 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 527021014323 triosephosphate isomerase; Provisional; Region: PRK14565 527021014324 substrate binding site [chemical binding]; other site 527021014325 dimer interface [polypeptide binding]; other site 527021014326 catalytic triad [active] 527021014327 Phosphoglycerate kinase; Region: PGK; pfam00162 527021014328 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 527021014329 substrate binding site [chemical binding]; other site 527021014330 hinge regions; other site 527021014331 ADP binding site [chemical binding]; other site 527021014332 catalytic site [active] 527021014333 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 527021014334 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 527021014335 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 527021014336 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 527021014337 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 527021014338 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 527021014339 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 527021014340 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 527021014341 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 527021014342 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 527021014343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 527021014344 Histidine kinase; Region: HisKA_3; pfam07730 527021014345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021014346 ATP binding site [chemical binding]; other site 527021014347 Mg2+ binding site [ion binding]; other site 527021014348 G-X-G motif; other site 527021014349 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021014350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021014351 active site 527021014352 phosphorylation site [posttranslational modification] 527021014353 intermolecular recognition site; other site 527021014354 dimerization interface [polypeptide binding]; other site 527021014355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021014356 DNA binding residues [nucleotide binding] 527021014357 dimerization interface [polypeptide binding]; other site 527021014358 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 527021014359 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 527021014360 stage V sporulation protein AD; Provisional; Region: PRK12404 527021014361 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 527021014362 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 527021014363 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 527021014364 Predicted membrane protein [Function unknown]; Region: COG2323 527021014365 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 527021014366 Clp protease; Region: CLP_protease; pfam00574 527021014367 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 527021014368 oligomer interface [polypeptide binding]; other site 527021014369 active site residues [active] 527021014370 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 527021014371 dimerization domain swap beta strand [polypeptide binding]; other site 527021014372 regulatory protein interface [polypeptide binding]; other site 527021014373 active site 527021014374 regulatory phosphorylation site [posttranslational modification]; other site 527021014375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 527021014376 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 527021014377 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 527021014378 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 527021014379 phosphate binding site [ion binding]; other site 527021014380 putative substrate binding pocket [chemical binding]; other site 527021014381 dimer interface [polypeptide binding]; other site 527021014382 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 527021014383 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 527021014384 putative active site [active] 527021014385 nucleotide binding site [chemical binding]; other site 527021014386 nudix motif; other site 527021014387 putative metal binding site [ion binding]; other site 527021014388 Domain of unknown function (DUF368); Region: DUF368; pfam04018 527021014389 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 527021014390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 527021014391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 527021014392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021014393 binding surface 527021014394 TPR motif; other site 527021014395 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021014396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021014397 binding surface 527021014398 Tetratricopeptide repeat; Region: TPR_16; pfam13432 527021014399 TPR motif; other site 527021014400 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 527021014401 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 527021014402 trimer interface [polypeptide binding]; other site 527021014403 active site 527021014404 substrate binding site [chemical binding]; other site 527021014405 CoA binding site [chemical binding]; other site 527021014406 pyrophosphatase PpaX; Provisional; Region: PRK13288 527021014407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021014408 active site 527021014409 motif I; other site 527021014410 motif II; other site 527021014411 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 527021014412 HPr kinase/phosphorylase; Provisional; Region: PRK05428 527021014413 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 527021014414 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 527021014415 Hpr binding site; other site 527021014416 active site 527021014417 homohexamer subunit interaction site [polypeptide binding]; other site 527021014418 Predicted membrane protein [Function unknown]; Region: COG1950 527021014419 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 527021014420 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 527021014421 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 527021014422 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 527021014423 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 527021014424 excinuclease ABC subunit B; Provisional; Region: PRK05298 527021014425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021014426 ATP binding site [chemical binding]; other site 527021014427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021014428 nucleotide binding region [chemical binding]; other site 527021014429 ATP-binding site [chemical binding]; other site 527021014430 Ultra-violet resistance protein B; Region: UvrB; pfam12344 527021014431 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 527021014432 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 527021014433 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021014434 DNA binding residues [nucleotide binding] 527021014435 dimer interface [polypeptide binding]; other site 527021014436 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 527021014437 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021014438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021014439 non-specific DNA binding site [nucleotide binding]; other site 527021014440 salt bridge; other site 527021014441 sequence-specific DNA binding site [nucleotide binding]; other site 527021014442 Predicted membrane protein [Function unknown]; Region: COG2855 527021014443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021014444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021014445 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 527021014446 putative dimerization interface [polypeptide binding]; other site 527021014447 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 527021014448 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 527021014449 DNA binding residues [nucleotide binding] 527021014450 putative dimer interface [polypeptide binding]; other site 527021014451 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 527021014452 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 527021014453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021014454 hypothetical protein; Provisional; Region: PRK12855 527021014455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 527021014456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 527021014457 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 527021014458 Walker A/P-loop; other site 527021014459 ATP binding site [chemical binding]; other site 527021014460 Q-loop/lid; other site 527021014461 ABC transporter signature motif; other site 527021014462 Walker B; other site 527021014463 D-loop; other site 527021014464 H-loop/switch region; other site 527021014465 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 527021014466 protein binding site [polypeptide binding]; other site 527021014467 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 527021014468 C-terminal peptidase (prc); Region: prc; TIGR00225 527021014469 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 527021014470 protein binding site [polypeptide binding]; other site 527021014471 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 527021014472 Catalytic dyad [active] 527021014473 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 527021014474 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 527021014475 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 527021014476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021014477 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 527021014478 Walker A/P-loop; other site 527021014479 ATP binding site [chemical binding]; other site 527021014480 Q-loop/lid; other site 527021014481 ABC transporter signature motif; other site 527021014482 Walker B; other site 527021014483 D-loop; other site 527021014484 H-loop/switch region; other site 527021014485 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 527021014486 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 527021014487 peptide chain release factor 2; Provisional; Region: PRK06746 527021014488 This domain is found in peptide chain release factors; Region: PCRF; smart00937 527021014489 RF-1 domain; Region: RF-1; pfam00472 527021014490 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 527021014491 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 527021014492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 527021014493 nucleotide binding region [chemical binding]; other site 527021014494 ATP-binding site [chemical binding]; other site 527021014495 SEC-C motif; Region: SEC-C; pfam02810 527021014496 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 527021014497 30S subunit binding site; other site 527021014498 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 527021014499 DNA-binding site [nucleotide binding]; DNA binding site 527021014500 RNA-binding motif; other site 527021014501 comF family protein; Region: comF; TIGR00201 527021014502 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021014503 active site 527021014504 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 527021014505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021014506 ATP binding site [chemical binding]; other site 527021014507 putative Mg++ binding site [ion binding]; other site 527021014508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021014509 nucleotide binding region [chemical binding]; other site 527021014510 ATP-binding site [chemical binding]; other site 527021014511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 527021014512 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 527021014513 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 527021014514 NlpC/P60 family; Region: NLPC_P60; pfam00877 527021014515 Predicted transcriptional regulators [Transcription]; Region: COG1733 527021014516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021014517 dimerization interface [polypeptide binding]; other site 527021014518 putative DNA binding site [nucleotide binding]; other site 527021014519 putative Zn2+ binding site [ion binding]; other site 527021014520 EDD domain protein, DegV family; Region: DegV; TIGR00762 527021014521 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 527021014522 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 527021014523 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 527021014524 Transcriptional regulator [Transcription]; Region: LytR; COG1316 527021014525 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 527021014526 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 527021014527 active site 527021014528 homodimer interface [polypeptide binding]; other site 527021014529 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 527021014530 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 527021014531 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 527021014532 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 527021014533 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 527021014534 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 527021014535 Mg++ binding site [ion binding]; other site 527021014536 putative catalytic motif [active] 527021014537 substrate binding site [chemical binding]; other site 527021014538 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 527021014539 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 527021014540 NodB motif; other site 527021014541 active site 527021014542 catalytic site [active] 527021014543 Zn binding site [ion binding]; other site 527021014544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021014545 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 527021014546 Walker A motif; other site 527021014547 ATP binding site [chemical binding]; other site 527021014548 Walker B motif; other site 527021014549 arginine finger; other site 527021014550 Transcriptional antiterminator [Transcription]; Region: COG3933 527021014551 PRD domain; Region: PRD; pfam00874 527021014552 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 527021014553 active pocket/dimerization site; other site 527021014554 active site 527021014555 phosphorylation site [posttranslational modification] 527021014556 PRD domain; Region: PRD; pfam00874 527021014557 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 527021014558 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 527021014559 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 527021014560 Chromate transporter; Region: Chromate_transp; pfam02417 527021014561 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 527021014562 putative active site [active] 527021014563 YdjC motif; other site 527021014564 Mg binding site [ion binding]; other site 527021014565 putative homodimer interface [polypeptide binding]; other site 527021014566 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 527021014567 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 527021014568 NAD binding site [chemical binding]; other site 527021014569 sugar binding site [chemical binding]; other site 527021014570 divalent metal binding site [ion binding]; other site 527021014571 tetramer (dimer of dimers) interface [polypeptide binding]; other site 527021014572 dimer interface [polypeptide binding]; other site 527021014573 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 527021014574 active site 527021014575 methionine cluster; other site 527021014576 phosphorylation site [posttranslational modification] 527021014577 metal binding site [ion binding]; metal-binding site 527021014578 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 527021014579 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 527021014580 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 527021014581 active site 527021014582 P-loop; other site 527021014583 phosphorylation site [posttranslational modification] 527021014584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021014585 S-adenosylmethionine binding site [chemical binding]; other site 527021014586 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 527021014587 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 527021014588 methionine cluster; other site 527021014589 active site 527021014590 phosphorylation site [posttranslational modification] 527021014591 metal binding site [ion binding]; metal-binding site 527021014592 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 527021014593 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 527021014594 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 527021014595 active site 527021014596 P-loop; other site 527021014597 phosphorylation site [posttranslational modification] 527021014598 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 527021014599 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 527021014600 Acyltransferase family; Region: Acyl_transf_3; pfam01757 527021014601 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 527021014602 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 527021014603 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 527021014604 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 527021014605 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 527021014606 Predicted membrane protein [Function unknown]; Region: COG1511 527021014607 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 527021014608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 527021014609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 527021014610 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 527021014611 putative dimerization interface [polypeptide binding]; other site 527021014612 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 527021014613 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 527021014614 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 527021014615 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 527021014616 transmembrane helices; other site 527021014617 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 527021014618 ThiC-associated domain; Region: ThiC-associated; pfam13667 527021014619 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 527021014620 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021014621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021014622 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021014623 L-lactate permease; Region: Lactate_perm; cl00701 527021014624 glycolate transporter; Provisional; Region: PRK09695 527021014625 Tic20-like protein; Region: Tic20; pfam09685 527021014626 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 527021014627 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 527021014628 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 527021014629 Sulfatase; Region: Sulfatase; pfam00884 527021014630 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 527021014631 homodimer interface [polypeptide binding]; other site 527021014632 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 527021014633 substrate-cofactor binding pocket; other site 527021014634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021014635 catalytic residue [active] 527021014636 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021014637 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021014638 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021014639 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021014640 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021014641 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 527021014642 NlpC/P60 family; Region: NLPC_P60; pfam00877 527021014643 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 527021014644 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 527021014645 Nucleoside recognition; Region: Gate; pfam07670 527021014646 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 527021014647 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 527021014648 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 527021014649 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 527021014650 DXD motif; other site 527021014651 BCCT family transporter; Region: BCCT; pfam02028 527021014652 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021014653 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021014654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 527021014655 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 527021014656 Predicted membrane protein [Function unknown]; Region: COG4640 527021014657 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 527021014658 Double zinc ribbon; Region: DZR; pfam12773 527021014659 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 527021014660 Double zinc ribbon; Region: DZR; pfam12773 527021014661 SNF2 Helicase protein; Region: DUF3670; pfam12419 527021014662 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 527021014663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021014664 ATP binding site [chemical binding]; other site 527021014665 putative Mg++ binding site [ion binding]; other site 527021014666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021014667 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 527021014668 nucleotide binding region [chemical binding]; other site 527021014669 ATP-binding site [chemical binding]; other site 527021014670 Predicted integral membrane protein [Function unknown]; Region: COG5652 527021014671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 527021014672 Transposase; Region: DEDD_Tnp_IS110; pfam01548 527021014673 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 527021014674 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 527021014675 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 527021014676 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 527021014677 ComK protein; Region: ComK; cl11560 527021014678 RNA polymerase factor sigma-70; Validated; Region: PRK06759 527021014679 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021014680 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021014681 DNA binding residues [nucleotide binding] 527021014682 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 527021014683 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 527021014684 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 527021014685 FtsX-like permease family; Region: FtsX; pfam02687 527021014686 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 527021014687 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 527021014688 Walker A/P-loop; other site 527021014689 ATP binding site [chemical binding]; other site 527021014690 Q-loop/lid; other site 527021014691 ABC transporter signature motif; other site 527021014692 Walker B; other site 527021014693 D-loop; other site 527021014694 H-loop/switch region; other site 527021014695 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 527021014696 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 527021014697 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021014698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021014699 non-specific DNA binding site [nucleotide binding]; other site 527021014700 salt bridge; other site 527021014701 sequence-specific DNA binding site [nucleotide binding]; other site 527021014702 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 527021014703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021014704 putative substrate translocation pore; other site 527021014705 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 527021014706 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 527021014707 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 527021014708 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 527021014709 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021014710 dimerization interface [polypeptide binding]; other site 527021014711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021014712 dimer interface [polypeptide binding]; other site 527021014713 phosphorylation site [posttranslational modification] 527021014714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021014715 ATP binding site [chemical binding]; other site 527021014716 Mg2+ binding site [ion binding]; other site 527021014717 G-X-G motif; other site 527021014718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021014719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021014720 active site 527021014721 phosphorylation site [posttranslational modification] 527021014722 intermolecular recognition site; other site 527021014723 dimerization interface [polypeptide binding]; other site 527021014724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021014725 DNA binding site [nucleotide binding] 527021014726 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 527021014727 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 527021014728 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 527021014729 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 527021014730 active site 527021014731 P-loop; other site 527021014732 phosphorylation site [posttranslational modification] 527021014733 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 527021014734 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 527021014735 active site 527021014736 phosphorylation site [posttranslational modification] 527021014737 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 527021014738 HTH domain; Region: HTH_11; pfam08279 527021014739 HTH domain; Region: HTH_11; pfam08279 527021014740 PRD domain; Region: PRD; pfam00874 527021014741 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 527021014742 active site 527021014743 P-loop; other site 527021014744 phosphorylation site [posttranslational modification] 527021014745 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 527021014746 active site 527021014747 phosphorylation site [posttranslational modification] 527021014748 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 527021014749 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 527021014750 NAD binding site [chemical binding]; other site 527021014751 homodimer interface [polypeptide binding]; other site 527021014752 active site 527021014753 substrate binding site [chemical binding]; other site 527021014754 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 527021014755 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 527021014756 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 527021014757 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 527021014758 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 527021014759 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 527021014760 active site 527021014761 Cupin domain; Region: Cupin_2; cl17218 527021014762 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 527021014763 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 527021014764 putative ADP-binding pocket [chemical binding]; other site 527021014765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 527021014766 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 527021014767 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 527021014768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 527021014769 putative homodimer interface [polypeptide binding]; other site 527021014770 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 527021014771 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 527021014772 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 527021014773 trimer interface [polypeptide binding]; other site 527021014774 active site 527021014775 substrate binding site [chemical binding]; other site 527021014776 CoA binding site [chemical binding]; other site 527021014777 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 527021014778 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 527021014779 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 527021014780 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 527021014781 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 527021014782 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 527021014783 Bacterial sugar transferase; Region: Bac_transf; pfam02397 527021014784 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 527021014785 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 527021014786 active site 527021014787 tetramer interface; other site 527021014788 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 527021014789 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 527021014790 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 527021014791 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 527021014792 Chain length determinant protein; Region: Wzz; cl15801 527021014793 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 527021014794 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 527021014795 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 527021014796 rod shape-determining protein Mbl; Provisional; Region: PRK13928 527021014797 MreB and similar proteins; Region: MreB_like; cd10225 527021014798 nucleotide binding site [chemical binding]; other site 527021014799 Mg binding site [ion binding]; other site 527021014800 putative protofilament interaction site [polypeptide binding]; other site 527021014801 RodZ interaction site [polypeptide binding]; other site 527021014802 Stage III sporulation protein D; Region: SpoIIID; pfam12116 527021014803 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 527021014804 Peptidase family M23; Region: Peptidase_M23; pfam01551 527021014805 CcmB protein; Region: CcmB; cl17444 527021014806 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 527021014807 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021014808 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021014809 Walker A/P-loop; other site 527021014810 ATP binding site [chemical binding]; other site 527021014811 Q-loop/lid; other site 527021014812 ABC transporter signature motif; other site 527021014813 Walker B; other site 527021014814 D-loop; other site 527021014815 H-loop/switch region; other site 527021014816 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 527021014817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021014818 Q-loop/lid; other site 527021014819 ABC transporter signature motif; other site 527021014820 Walker B; other site 527021014821 D-loop; other site 527021014822 H-loop/switch region; other site 527021014823 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 527021014824 LytTr DNA-binding domain; Region: LytTR; pfam04397 527021014825 Stage II sporulation protein; Region: SpoIID; pfam08486 527021014826 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 527021014827 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 527021014828 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 527021014829 hinge; other site 527021014830 active site 527021014831 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 527021014832 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 527021014833 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 527021014834 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 527021014835 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 527021014836 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 527021014837 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 527021014838 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 527021014839 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 527021014840 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 527021014841 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 527021014842 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 527021014843 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 527021014844 4Fe-4S binding domain; Region: Fer4; cl02805 527021014845 4Fe-4S binding domain; Region: Fer4; pfam00037 527021014846 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 527021014847 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 527021014848 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 527021014849 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 527021014850 NADH dehydrogenase subunit C; Validated; Region: PRK07735 527021014851 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 527021014852 NADH dehydrogenase subunit B; Validated; Region: PRK06411 527021014853 NADH dehydrogenase subunit A; Validated; Region: PRK07756 527021014854 PAS domain S-box; Region: sensory_box; TIGR00229 527021014855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021014856 putative active site [active] 527021014857 heme pocket [chemical binding]; other site 527021014858 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 527021014859 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 527021014860 metal binding site [ion binding]; metal-binding site 527021014861 active site 527021014862 I-site; other site 527021014863 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 527021014864 Protein of unknown function (DUF975); Region: DUF975; cl10504 527021014865 Protein of unknown function (DUF975); Region: DUF975; cl10504 527021014866 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 527021014867 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 527021014868 gamma subunit interface [polypeptide binding]; other site 527021014869 epsilon subunit interface [polypeptide binding]; other site 527021014870 LBP interface [polypeptide binding]; other site 527021014871 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 527021014872 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 527021014873 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 527021014874 alpha subunit interaction interface [polypeptide binding]; other site 527021014875 Walker A motif; other site 527021014876 ATP binding site [chemical binding]; other site 527021014877 Walker B motif; other site 527021014878 inhibitor binding site; inhibition site 527021014879 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 527021014880 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 527021014881 core domain interface [polypeptide binding]; other site 527021014882 delta subunit interface [polypeptide binding]; other site 527021014883 epsilon subunit interface [polypeptide binding]; other site 527021014884 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 527021014885 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 527021014886 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 527021014887 beta subunit interaction interface [polypeptide binding]; other site 527021014888 Walker A motif; other site 527021014889 ATP binding site [chemical binding]; other site 527021014890 Walker B motif; other site 527021014891 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 527021014892 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 527021014893 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 527021014894 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 527021014895 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 527021014896 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 527021014897 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 527021014898 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 527021014899 ATP synthase I chain; Region: ATP_synt_I; pfam03899 527021014900 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 527021014901 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 527021014902 active site 527021014903 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 527021014904 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 527021014905 dimer interface [polypeptide binding]; other site 527021014906 active site 527021014907 glycine-pyridoxal phosphate binding site [chemical binding]; other site 527021014908 folate binding site [chemical binding]; other site 527021014909 hypothetical protein; Provisional; Region: PRK13690 527021014910 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 527021014911 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 527021014912 Low molecular weight phosphatase family; Region: LMWPc; cd00115 527021014913 active site 527021014914 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 527021014915 HPr interaction site; other site 527021014916 glycerol kinase (GK) interaction site [polypeptide binding]; other site 527021014917 active site 527021014918 phosphorylation site [posttranslational modification] 527021014919 Predicted membrane protein [Function unknown]; Region: COG2259 527021014920 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 527021014921 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 527021014922 Predicted membrane protein [Function unknown]; Region: COG1971 527021014923 Domain of unknown function DUF; Region: DUF204; pfam02659 527021014924 Domain of unknown function DUF; Region: DUF204; pfam02659 527021014925 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 527021014926 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 527021014927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021014928 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 527021014929 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 527021014930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021014931 S-adenosylmethionine binding site [chemical binding]; other site 527021014932 peptide chain release factor 1; Validated; Region: prfA; PRK00591 527021014933 This domain is found in peptide chain release factors; Region: PCRF; smart00937 527021014934 RF-1 domain; Region: RF-1; pfam00472 527021014935 thymidine kinase; Provisional; Region: PRK04296 527021014936 LabA_like proteins; Region: LabA_like/DUF88; cl10034 527021014937 putative metal binding site [ion binding]; other site 527021014938 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 527021014939 transcription termination factor Rho; Provisional; Region: rho; PRK09376 527021014940 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 527021014941 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 527021014942 RNA binding site [nucleotide binding]; other site 527021014943 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 527021014944 multimer interface [polypeptide binding]; other site 527021014945 Walker A motif; other site 527021014946 ATP binding site [chemical binding]; other site 527021014947 Walker B motif; other site 527021014948 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 527021014949 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 527021014950 putative active site [active] 527021014951 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 527021014952 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 527021014953 hinge; other site 527021014954 active site 527021014955 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 527021014956 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 527021014957 intersubunit interface [polypeptide binding]; other site 527021014958 active site 527021014959 zinc binding site [ion binding]; other site 527021014960 Na+ binding site [ion binding]; other site 527021014961 Response regulator receiver domain; Region: Response_reg; pfam00072 527021014962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021014963 active site 527021014964 phosphorylation site [posttranslational modification] 527021014965 intermolecular recognition site; other site 527021014966 dimerization interface [polypeptide binding]; other site 527021014967 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 527021014968 CTP synthetase; Validated; Region: pyrG; PRK05380 527021014969 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 527021014970 Catalytic site [active] 527021014971 active site 527021014972 UTP binding site [chemical binding]; other site 527021014973 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 527021014974 active site 527021014975 putative oxyanion hole; other site 527021014976 catalytic triad [active] 527021014977 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 527021014978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021014979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021014980 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 527021014981 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 527021014982 FAD binding site [chemical binding]; other site 527021014983 homotetramer interface [polypeptide binding]; other site 527021014984 substrate binding pocket [chemical binding]; other site 527021014985 catalytic base [active] 527021014986 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 527021014987 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 527021014988 FAD binding site [chemical binding]; other site 527021014989 homotetramer interface [polypeptide binding]; other site 527021014990 substrate binding pocket [chemical binding]; other site 527021014991 catalytic base [active] 527021014992 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 527021014993 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 527021014994 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 527021014995 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 527021014996 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 527021014997 dimer interface [polypeptide binding]; other site 527021014998 active site 527021014999 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 527021015000 4Fe-4S binding domain; Region: Fer4; cl02805 527021015001 Cysteine-rich domain; Region: CCG; pfam02754 527021015002 Cysteine-rich domain; Region: CCG; pfam02754 527021015003 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 527021015004 PLD-like domain; Region: PLDc_2; pfam13091 527021015005 putative active site [active] 527021015006 catalytic site [active] 527021015007 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 527021015008 PLD-like domain; Region: PLDc_2; pfam13091 527021015009 putative active site [active] 527021015010 catalytic site [active] 527021015011 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 527021015012 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 527021015013 PAS domain S-box; Region: sensory_box; TIGR00229 527021015014 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 527021015015 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 527021015016 metal binding site [ion binding]; metal-binding site 527021015017 active site 527021015018 I-site; other site 527021015019 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 527021015020 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 527021015021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021015022 non-specific DNA binding site [nucleotide binding]; other site 527021015023 salt bridge; other site 527021015024 sequence-specific DNA binding site [nucleotide binding]; other site 527021015025 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 527021015026 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 527021015027 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 527021015028 active site 527021015029 Zn binding site [ion binding]; other site 527021015030 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021015031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021015032 active site 527021015033 phosphorylation site [posttranslational modification] 527021015034 intermolecular recognition site; other site 527021015035 dimerization interface [polypeptide binding]; other site 527021015036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021015037 DNA binding residues [nucleotide binding] 527021015038 dimerization interface [polypeptide binding]; other site 527021015039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 527021015040 Histidine kinase; Region: HisKA_3; pfam07730 527021015041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021015042 ATP binding site [chemical binding]; other site 527021015043 Mg2+ binding site [ion binding]; other site 527021015044 G-X-G motif; other site 527021015045 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 527021015046 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 527021015047 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021015048 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 527021015049 Walker A/P-loop; other site 527021015050 ATP binding site [chemical binding]; other site 527021015051 Q-loop/lid; other site 527021015052 ABC transporter signature motif; other site 527021015053 Walker B; other site 527021015054 D-loop; other site 527021015055 H-loop/switch region; other site 527021015056 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 527021015057 active site 527021015058 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 527021015059 Collagen binding domain; Region: Collagen_bind; pfam05737 527021015060 Collagen binding domain; Region: Collagen_bind; pfam05737 527021015061 Collagen binding domain; Region: Collagen_bind; pfam05737 527021015062 Collagen binding domain; Region: Collagen_bind; pfam05737 527021015063 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015064 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015065 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015066 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015067 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015068 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015069 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015070 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 527021015071 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015072 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015073 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015074 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015075 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 527021015076 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015077 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015078 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015079 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015080 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015081 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 527021015082 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015083 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015084 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015085 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015086 Cna protein B-type domain; Region: Cna_B; pfam05738 527021015087 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 527021015088 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 527021015089 PA/protease or protease-like domain interface [polypeptide binding]; other site 527021015090 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 527021015091 Peptidase family M28; Region: Peptidase_M28; pfam04389 527021015092 metal binding site [ion binding]; metal-binding site 527021015093 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 527021015094 RNA polymerase sigma factor; Provisional; Region: PRK12522 527021015095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021015096 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021015097 DNA binding residues [nucleotide binding] 527021015098 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 527021015099 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 527021015100 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 527021015101 active site 527021015102 HIGH motif; other site 527021015103 KMSK motif region; other site 527021015104 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 527021015105 tRNA binding surface [nucleotide binding]; other site 527021015106 anticodon binding site; other site 527021015107 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 527021015108 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 527021015109 putative dimer interface [polypeptide binding]; other site 527021015110 catalytic triad [active] 527021015111 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 527021015112 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 527021015113 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 527021015114 agmatinase; Region: agmatinase; TIGR01230 527021015115 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 527021015116 putative active site [active] 527021015117 Mn binding site [ion binding]; other site 527021015118 spermidine synthase; Provisional; Region: PRK00811 527021015119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021015120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021015121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 527021015122 putative substrate translocation pore; other site 527021015123 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 527021015124 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 527021015125 DNA binding residues [nucleotide binding] 527021015126 putative dimer interface [polypeptide binding]; other site 527021015127 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 527021015128 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 527021015129 active site 527021015130 catalytic site [active] 527021015131 metal binding site [ion binding]; metal-binding site 527021015132 dimer interface [polypeptide binding]; other site 527021015133 Transglycosylase; Region: Transgly; pfam00912 527021015134 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 527021015135 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 527021015136 YwhD family; Region: YwhD; pfam08741 527021015137 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 527021015138 Peptidase family M50; Region: Peptidase_M50; pfam02163 527021015139 active site 527021015140 putative substrate binding region [chemical binding]; other site 527021015141 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 527021015142 active site 1 [active] 527021015143 dimer interface [polypeptide binding]; other site 527021015144 hexamer interface [polypeptide binding]; other site 527021015145 active site 2 [active] 527021015146 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 527021015147 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021015148 Zn2+ binding site [ion binding]; other site 527021015149 Mg2+ binding site [ion binding]; other site 527021015150 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 527021015151 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 527021015152 intersubunit interface [polypeptide binding]; other site 527021015153 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 527021015154 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 527021015155 Walker A/P-loop; other site 527021015156 ATP binding site [chemical binding]; other site 527021015157 Q-loop/lid; other site 527021015158 ABC transporter signature motif; other site 527021015159 Walker B; other site 527021015160 D-loop; other site 527021015161 H-loop/switch region; other site 527021015162 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 527021015163 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021015164 ABC-ATPase subunit interface; other site 527021015165 dimer interface [polypeptide binding]; other site 527021015166 putative PBP binding regions; other site 527021015167 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 527021015168 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 527021015169 ABC-ATPase subunit interface; other site 527021015170 dimer interface [polypeptide binding]; other site 527021015171 putative PBP binding regions; other site 527021015172 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 527021015173 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 527021015174 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 527021015175 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 527021015176 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 527021015177 putative heme peroxidase; Provisional; Region: PRK12276 527021015178 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 527021015179 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 527021015180 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 527021015181 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 527021015182 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 527021015183 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 527021015184 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 527021015185 Ion channel; Region: Ion_trans_2; pfam07885 527021015186 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 527021015187 TrkA-N domain; Region: TrkA_N; pfam02254 527021015188 TrkA-C domain; Region: TrkA_C; pfam02080 527021015189 putative uracil/xanthine transporter; Provisional; Region: PRK11412 527021015190 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 527021015191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021015192 motif II; other site 527021015193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021015194 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 527021015195 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 527021015196 ligand binding site [chemical binding]; other site 527021015197 active site 527021015198 UGI interface [polypeptide binding]; other site 527021015199 catalytic site [active] 527021015200 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 527021015201 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 527021015202 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 527021015203 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 527021015204 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 527021015205 Walker A/P-loop; other site 527021015206 ATP binding site [chemical binding]; other site 527021015207 Q-loop/lid; other site 527021015208 ABC transporter signature motif; other site 527021015209 Walker B; other site 527021015210 D-loop; other site 527021015211 H-loop/switch region; other site 527021015212 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 527021015213 active site 527021015214 catalytic triad [active] 527021015215 oxyanion hole [active] 527021015216 Transcriptional regulators [Transcription]; Region: PurR; COG1609 527021015217 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 527021015218 DNA binding site [nucleotide binding] 527021015219 domain linker motif; other site 527021015220 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 527021015221 putative dimerization interface [polypeptide binding]; other site 527021015222 putative ligand binding site [chemical binding]; other site 527021015223 Predicted membrane protein [Function unknown]; Region: COG2364 527021015224 homoserine dehydrogenase; Provisional; Region: PRK06349 527021015225 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 527021015226 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 527021015227 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 527021015228 Homoserine O-succinyltransferase; Region: HTS; pfam04204 527021015229 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 527021015230 proposed active site lysine [active] 527021015231 conserved cys residue [active] 527021015232 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 527021015233 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 527021015234 homodimer interface [polypeptide binding]; other site 527021015235 substrate-cofactor binding pocket; other site 527021015236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 527021015237 catalytic residue [active] 527021015238 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 527021015239 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 527021015240 Cl- selectivity filter; other site 527021015241 Cl- binding residues [ion binding]; other site 527021015242 pore gating glutamate residue; other site 527021015243 dimer interface [polypeptide binding]; other site 527021015244 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 527021015245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 527021015246 active site 527021015247 motif I; other site 527021015248 motif II; other site 527021015249 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 527021015250 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 527021015251 ligand binding site [chemical binding]; other site 527021015252 flexible hinge region; other site 527021015253 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 527021015254 azoreductase; Provisional; Region: PRK13556 527021015255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021015256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021015257 active site 527021015258 phosphorylation site [posttranslational modification] 527021015259 intermolecular recognition site; other site 527021015260 dimerization interface [polypeptide binding]; other site 527021015261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021015262 DNA binding residues [nucleotide binding] 527021015263 dimerization interface [polypeptide binding]; other site 527021015264 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 527021015265 GAF domain; Region: GAF; pfam01590 527021015266 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 527021015267 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 527021015268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 527021015269 Histidine kinase; Region: HisKA_3; pfam07730 527021015270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021015271 ATP binding site [chemical binding]; other site 527021015272 Mg2+ binding site [ion binding]; other site 527021015273 G-X-G motif; other site 527021015274 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 527021015275 dimer interface [polypeptide binding]; other site 527021015276 substrate binding site [chemical binding]; other site 527021015277 ATP binding site [chemical binding]; other site 527021015278 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 527021015279 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 527021015280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 527021015281 metal binding site [ion binding]; metal-binding site 527021015282 active site 527021015283 I-site; other site 527021015284 Protein of unknown function (DUF466); Region: DUF466; pfam04328 527021015285 carbon starvation protein A; Provisional; Region: PRK15015 527021015286 Carbon starvation protein CstA; Region: CstA; pfam02554 527021015287 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 527021015288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021015289 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 527021015290 active site 527021015291 phosphorylation site [posttranslational modification] 527021015292 intermolecular recognition site; other site 527021015293 dimerization interface [polypeptide binding]; other site 527021015294 LytTr DNA-binding domain; Region: LytTR; pfam04397 527021015295 benzoate transport; Region: 2A0115; TIGR00895 527021015296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021015297 putative substrate translocation pore; other site 527021015298 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 527021015299 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 527021015300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 527021015301 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 527021015302 Predicted membrane protein [Function unknown]; Region: COG2860 527021015303 UPF0126 domain; Region: UPF0126; pfam03458 527021015304 UPF0126 domain; Region: UPF0126; pfam03458 527021015305 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 527021015306 heme-binding site [chemical binding]; other site 527021015307 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 527021015308 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 527021015309 dimer interface [polypeptide binding]; other site 527021015310 putative CheW interface [polypeptide binding]; other site 527021015311 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 527021015312 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 527021015313 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 527021015314 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 527021015315 Ligand binding site; other site 527021015316 Putative Catalytic site; other site 527021015317 DXD motif; other site 527021015318 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 527021015319 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 527021015320 active site 527021015321 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 527021015322 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 527021015323 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 527021015324 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 527021015325 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 527021015326 Ligand binding site; other site 527021015327 Putative Catalytic site; other site 527021015328 DXD motif; other site 527021015329 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 527021015330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021015331 NAD(P) binding site [chemical binding]; other site 527021015332 active site 527021015333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021015334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021015335 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 527021015336 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021015337 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021015338 ABC transporter; Region: ABC_tran_2; pfam12848 527021015339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 527021015340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 527021015341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 527021015342 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 527021015343 Protein export membrane protein; Region: SecD_SecF; cl14618 527021015344 methionine sulfoxide reductase A; Provisional; Region: PRK14054 527021015345 methionine sulfoxide reductase B; Provisional; Region: PRK00222 527021015346 SelR domain; Region: SelR; pfam01641 527021015347 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 527021015348 antiholin-like protein LrgB; Provisional; Region: PRK04288 527021015349 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 527021015350 two-component response regulator; Provisional; Region: PRK14084 527021015351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021015352 active site 527021015353 phosphorylation site [posttranslational modification] 527021015354 intermolecular recognition site; other site 527021015355 dimerization interface [polypeptide binding]; other site 527021015356 LytTr DNA-binding domain; Region: LytTR; pfam04397 527021015357 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 527021015358 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 527021015359 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 527021015360 Histidine kinase; Region: His_kinase; pfam06580 527021015361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021015362 ATP binding site [chemical binding]; other site 527021015363 Mg2+ binding site [ion binding]; other site 527021015364 G-X-G motif; other site 527021015365 benzoate transport; Region: 2A0115; TIGR00895 527021015366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 527021015367 putative substrate translocation pore; other site 527021015368 BCCT family transporter; Region: BCCT; pfam02028 527021015369 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 527021015370 active site 527021015371 dimer interface [polypeptide binding]; other site 527021015372 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 527021015373 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 527021015374 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 527021015375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 527021015376 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 527021015377 NAD(P) binding site [chemical binding]; other site 527021015378 active site 527021015379 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 527021015380 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 527021015381 UDP-glucose 4-epimerase; Region: PLN02240 527021015382 NAD binding site [chemical binding]; other site 527021015383 homodimer interface [polypeptide binding]; other site 527021015384 active site 527021015385 substrate binding site [chemical binding]; other site 527021015386 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 527021015387 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 527021015388 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 527021015389 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 527021015390 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 527021015391 ATP binding site [chemical binding]; other site 527021015392 Mg++ binding site [ion binding]; other site 527021015393 motif III; other site 527021015394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021015395 nucleotide binding region [chemical binding]; other site 527021015396 ATP-binding site [chemical binding]; other site 527021015397 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 527021015398 RNA binding site [nucleotide binding]; other site 527021015399 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 527021015400 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 527021015401 active site 527021015402 oligoendopeptidase F; Region: pepF; TIGR00181 527021015403 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 527021015404 active site 527021015405 Zn binding site [ion binding]; other site 527021015406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 527021015407 FeS/SAM binding site; other site 527021015408 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 527021015409 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 527021015410 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 527021015411 GAF domain; Region: GAF_3; pfam13492 527021015412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021015413 PAS domain; Region: PAS_9; pfam13426 527021015414 putative active site [active] 527021015415 heme pocket [chemical binding]; other site 527021015416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021015417 dimer interface [polypeptide binding]; other site 527021015418 phosphorylation site [posttranslational modification] 527021015419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021015420 ATP binding site [chemical binding]; other site 527021015421 Mg2+ binding site [ion binding]; other site 527021015422 G-X-G motif; other site 527021015423 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 527021015424 YyzF-like protein; Region: YyzF; pfam14116 527021015425 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 527021015426 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 527021015427 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 527021015428 protein binding site [polypeptide binding]; other site 527021015429 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 527021015430 YycH protein; Region: YycI; pfam09648 527021015431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 527021015432 YycH protein; Region: YycH; pfam07435 527021015433 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 527021015434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 527021015435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 527021015436 dimerization interface [polypeptide binding]; other site 527021015437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 527021015438 putative active site [active] 527021015439 heme pocket [chemical binding]; other site 527021015440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 527021015441 dimer interface [polypeptide binding]; other site 527021015442 phosphorylation site [posttranslational modification] 527021015443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021015444 ATP binding site [chemical binding]; other site 527021015445 Mg2+ binding site [ion binding]; other site 527021015446 G-X-G motif; other site 527021015447 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 527021015448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021015449 active site 527021015450 phosphorylation site [posttranslational modification] 527021015451 intermolecular recognition site; other site 527021015452 dimerization interface [polypeptide binding]; other site 527021015453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 527021015454 DNA binding site [nucleotide binding] 527021015455 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 527021015456 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 527021015457 GDP-binding site [chemical binding]; other site 527021015458 ACT binding site; other site 527021015459 IMP binding site; other site 527021015460 replicative DNA helicase; Provisional; Region: PRK05748 527021015461 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 527021015462 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 527021015463 Walker A motif; other site 527021015464 ATP binding site [chemical binding]; other site 527021015465 Walker B motif; other site 527021015466 DNA binding loops [nucleotide binding] 527021015467 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 527021015468 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 527021015469 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 527021015470 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 527021015471 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 527021015472 DHH family; Region: DHH; pfam01368 527021015473 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 527021015474 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 527021015475 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 527021015476 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 527021015477 dimer interface [polypeptide binding]; other site 527021015478 ssDNA binding site [nucleotide binding]; other site 527021015479 tetramer (dimer of dimers) interface [polypeptide binding]; other site 527021015480 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 527021015481 GTP-binding protein YchF; Reviewed; Region: PRK09601 527021015482 YchF GTPase; Region: YchF; cd01900 527021015483 G1 box; other site 527021015484 GTP/Mg2+ binding site [chemical binding]; other site 527021015485 Switch I region; other site 527021015486 G2 box; other site 527021015487 Switch II region; other site 527021015488 G3 box; other site 527021015489 G4 box; other site 527021015490 G5 box; other site 527021015491 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 527021015492 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 527021015493 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 527021015494 Mechanosensitive ion channel; Region: MS_channel; pfam00924 527021015495 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 527021015496 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 527021015497 ParB-like nuclease domain; Region: ParB; smart00470 527021015498 KorB domain; Region: KorB; pfam08535 527021015499 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 527021015500 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 527021015501 P-loop; other site 527021015502 Magnesium ion binding site [ion binding]; other site 527021015503 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 527021015504 Magnesium ion binding site [ion binding]; other site 527021015505 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 527021015506 ParB-like nuclease domain; Region: ParBc; pfam02195 527021015507 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 527021015508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021015509 S-adenosylmethionine binding site [chemical binding]; other site 527021015510 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 527021015511 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 527021015512 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 527021015513 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 527021015514 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 527021015515 trmE is a tRNA modification GTPase; Region: trmE; cd04164 527021015516 G1 box; other site 527021015517 GTP/Mg2+ binding site [chemical binding]; other site 527021015518 Switch I region; other site 527021015519 G2 box; other site 527021015520 Switch II region; other site 527021015521 G3 box; other site 527021015522 G4 box; other site 527021015523 G5 box; other site 527021015524 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 527021015525 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 527021015526 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 527021015527 G-X-X-G motif; other site 527021015528 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 527021015529 RxxxH motif; other site 527021015530 OxaA-like protein precursor; Validated; Region: PRK02944 527021015531 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 527021015532 ribonuclease P; Reviewed; Region: rnpA; PRK00499 527021015533 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 527021015534 Protein of unknown function DUF91; Region: DUF91; cl00709 527021015535 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 527021015536 ligand binding site [chemical binding]; other site 527021015537 active site 527021015538 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 527021015539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 527021015540 ATP binding site [chemical binding]; other site 527021015541 Mg2+ binding site [ion binding]; other site 527021015542 G-X-G motif; other site 527021015543 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 527021015544 anchoring element; other site 527021015545 dimer interface [polypeptide binding]; other site 527021015546 ATP binding site [chemical binding]; other site 527021015547 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 527021015548 active site 527021015549 putative metal-binding site [ion binding]; other site 527021015550 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 527021015551 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 527021015552 DNA gyrase subunit A; Validated; Region: PRK05560 527021015553 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 527021015554 CAP-like domain; other site 527021015555 active site 527021015556 primary dimer interface [polypeptide binding]; other site 527021015557 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 527021015558 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 527021015559 active site 527021015560 putative DNA-binding cleft [nucleotide binding]; other site 527021015561 dimer interface [polypeptide binding]; other site 527021015562 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 527021015563 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 527021015564 dimer interface [polypeptide binding]; other site 527021015565 ssDNA binding site [nucleotide binding]; other site 527021015566 tetramer (dimer of dimers) interface [polypeptide binding]; other site 527021015567 DNA primase, catalytic core; Region: dnaG; TIGR01391 527021015568 CHC2 zinc finger; Region: zf-CHC2; cl17510 527021015569 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 527021015570 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 527021015571 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 527021015572 DHH family; Region: DHH; pfam01368 527021015573 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 527021015574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 527021015575 Coenzyme A binding pocket [chemical binding]; other site 527021015576 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 527021015577 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 527021015578 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 527021015579 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 527021015580 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 527021015581 Protein of unknown function, DUF488; Region: DUF488; cl01246 527021015582 YesK-like protein; Region: YesK; pfam14150 527021015583 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 527021015584 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 527021015585 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 527021015586 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 527021015587 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 527021015588 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 527021015589 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 527021015590 Uncharacterized conserved protein [Function unknown]; Region: COG1479 527021015591 Protein of unknown function DUF262; Region: DUF262; pfam03235 527021015592 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 527021015593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 527021015594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 527021015595 Coenzyme A binding pocket [chemical binding]; other site 527021015596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021015597 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 527021015598 Uncharacterized conserved protein [Function unknown]; Region: COG1284 527021015599 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 527021015600 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 527021015601 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 527021015602 anthranilate synthase component I; Provisional; Region: PRK13564 527021015603 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 527021015604 Probable zinc-binding domain; Region: zf-trcl; pfam13451 527021015605 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 527021015606 Thg1 C terminal domain; Region: Thg1C; pfam14413 527021015607 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 527021015608 metal ion-dependent adhesion site (MIDAS); other site 527021015609 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 527021015610 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 527021015611 nucleotide binding pocket [chemical binding]; other site 527021015612 K-X-D-G motif; other site 527021015613 catalytic site [active] 527021015614 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 527021015615 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 527021015616 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 527021015617 Dimer interface [polypeptide binding]; other site 527021015618 BRCT sequence motif; other site 527021015619 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 527021015620 AAA domain; Region: AAA_30; pfam13604 527021015621 Family description; Region: UvrD_C_2; pfam13538 527021015622 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 527021015623 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 527021015624 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 527021015625 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 527021015626 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 527021015627 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 527021015628 Catalytic site [active] 527021015629 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 527021015630 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 527021015631 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 527021015632 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 527021015633 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 527021015634 PrcB C-terminal; Region: PrcB_C; pfam14343 527021015635 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 527021015636 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021015637 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 527021015638 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 527021015639 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 527021015640 Walker A motif; other site 527021015641 ATP binding site [chemical binding]; other site 527021015642 Walker B motif; other site 527021015643 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 527021015644 Transcriptional regulator; Region: Rrf2; cl17282 527021015645 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 527021015646 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 527021015647 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 527021015648 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 527021015649 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 527021015650 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 527021015651 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 527021015652 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 527021015653 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 527021015654 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 527021015655 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 527021015656 generic binding surface II; other site 527021015657 generic binding surface I; other site 527021015658 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021015659 Zn2+ binding site [ion binding]; other site 527021015660 Mg2+ binding site [ion binding]; other site 527021015661 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 527021015662 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 527021015663 active site 527021015664 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 527021015665 Peptidase family M50; Region: Peptidase_M50; pfam02163 527021015666 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 527021015667 active site 527021015668 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 527021015669 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 527021015670 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 527021015671 SprT homologues; Region: SprT; cl01182 527021015672 SprT-like family; Region: SprT-like; pfam10263 527021015673 SprT-like family; Region: SprT-like; pfam10263 527021015674 SprT homologues; Region: SprT; cl01182 527021015675 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 527021015676 YopX protein; Region: YopX; cl09859 527021015677 Methyltransferase TYW3; Region: TYW3; cl00689 527021015678 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 527021015679 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 527021015680 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 527021015681 active site 527021015682 Int/Topo IB signature motif; other site 527021015683 DNA binding site [nucleotide binding] 527021015684 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 527021015685 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 527021015686 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 527021015687 active site 527021015688 NTP binding site [chemical binding]; other site 527021015689 metal binding triad [ion binding]; metal-binding site 527021015690 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 527021015691 Protein of unknown function DUF262; Region: DUF262; pfam03235 527021015692 Uncharacterized conserved protein [Function unknown]; Region: COG1479 527021015693 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 527021015694 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 527021015695 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 527021015696 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 527021015697 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283 527021015698 nad+ binding pocket [chemical binding]; other site 527021015699 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 527021015700 active site 527021015701 NTP binding site [chemical binding]; other site 527021015702 metal binding triad [ion binding]; metal-binding site 527021015703 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 527021015704 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 527021015705 active site 527021015706 GTPase CgtA; Reviewed; Region: obgE; PRK12297 527021015707 GTP1/OBG; Region: GTP1_OBG; pfam01018 527021015708 Obg GTPase; Region: Obg; cd01898 527021015709 G1 box; other site 527021015710 GTP/Mg2+ binding site [chemical binding]; other site 527021015711 Switch I region; other site 527021015712 G2 box; other site 527021015713 G3 box; other site 527021015714 Switch II region; other site 527021015715 G4 box; other site 527021015716 G5 box; other site 527021015717 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 527021015718 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 527021015719 hypothetical protein; Provisional; Region: PRK14553 527021015720 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 527021015721 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021015722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 527021015723 binding surface 527021015724 TPR motif; other site 527021015725 HD domain; Region: HD_4; pfam13328 527021015726 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 527021015727 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 527021015728 RNA/DNA hybrid binding site [nucleotide binding]; other site 527021015729 active site 527021015730 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 527021015731 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 527021015732 PemK-like protein; Region: PemK; pfam02452 527021015733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 527021015734 YopX protein; Region: YopX; cl09859 527021015735 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 527021015736 SprT homologues; Region: SprT; cl01182 527021015737 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 527021015738 C2 domain; Region: C2; cl14603 527021015739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021015740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021015741 non-specific DNA binding site [nucleotide binding]; other site 527021015742 salt bridge; other site 527021015743 sequence-specific DNA binding site [nucleotide binding]; other site 527021015744 Di-sulfide bridge nucleocytoplasmic transport domain; Region: Brr6_like_C_C; cl12377 527021015745 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 527021015746 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 527021015747 putative metal binding site [ion binding]; other site 527021015748 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 527021015749 ribonucleoside-diphosphate reductase subunit alpha; Provisional; Region: nrdA; PHA02572 527021015750 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 527021015751 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 527021015752 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 527021015753 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 527021015754 active site 527021015755 DNA binding site [nucleotide binding] 527021015756 Int/Topo IB signature motif; other site 527021015757 FtsH Extracellular; Region: FtsH_ext; pfam06480 527021015758 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 527021015759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021015760 Walker A motif; other site 527021015761 ATP binding site [chemical binding]; other site 527021015762 Walker B motif; other site 527021015763 arginine finger; other site 527021015764 Peptidase family M41; Region: Peptidase_M41; pfam01434 527021015765 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 527021015766 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 527021015767 active site 527021015768 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021015769 Zn2+ binding site [ion binding]; other site 527021015770 Mg2+ binding site [ion binding]; other site 527021015771 Nuclease-related domain; Region: NERD; pfam08378 527021015772 Bax inhibitor 1 like; Region: BaxI_1; cl17691 527021015773 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 527021015774 NlpC/P60 family; Region: NLPC_P60; pfam00877 527021015775 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 527021015776 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 527021015777 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 527021015778 active site 527021015779 NTP binding site [chemical binding]; other site 527021015780 metal binding triad [ion binding]; metal-binding site 527021015781 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 527021015782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 527021015783 YopX protein; Region: YopX; cl09859 527021015784 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021015785 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 527021015786 active site 527021015787 metal binding site [ion binding]; metal-binding site 527021015788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021015789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021015790 non-specific DNA binding site [nucleotide binding]; other site 527021015791 salt bridge; other site 527021015792 sequence-specific DNA binding site [nucleotide binding]; other site 527021015793 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 527021015794 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 527021015795 Transglycosylase; Region: Transgly; pfam00912 527021015796 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 527021015797 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 527021015798 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 527021015799 putative DNA binding surface [nucleotide binding]; other site 527021015800 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 527021015801 active site 527021015802 catalytic site [active] 527021015803 substrate binding site [chemical binding]; other site 527021015804 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 527021015805 ATP binding site [chemical binding]; other site 527021015806 Walker B motif; other site 527021015807 YopX protein; Region: YopX; cl09859 527021015808 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 527021015809 active site 527021015810 catalytic residues [active] 527021015811 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 527021015812 ADP-ribose binding site [chemical binding]; other site 527021015813 Protein of unknown function DUF262; Region: DUF262; pfam03235 527021015814 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 527021015815 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 527021015816 putative active site [active] 527021015817 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 527021015818 chaperone protein DnaJ; Provisional; Region: PRK14280 527021015819 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 527021015820 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 527021015821 TROVE domain; Region: TROVE; pfam05731 527021015822 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 527021015823 classical (c) SDRs; Region: SDR_c; cd05233 527021015824 NAD(P) binding site [chemical binding]; other site 527021015825 active site 527021015826 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 527021015827 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 527021015828 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 527021015829 ssDNA binding site; other site 527021015830 generic binding surface II; other site 527021015831 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 527021015832 ATP binding site [chemical binding]; other site 527021015833 putative Mg++ binding site [ion binding]; other site 527021015834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021015835 nucleotide binding region [chemical binding]; other site 527021015836 ATP-binding site [chemical binding]; other site 527021015837 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 527021015838 Mg binding site [ion binding]; other site 527021015839 nucleotide binding site [chemical binding]; other site 527021015840 putative protofilament interface [polypeptide binding]; other site 527021015841 PemK-like protein; Region: PemK; pfam02452 527021015842 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 527021015843 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 527021015844 catalytic site [active] 527021015845 G-X2-G-X-G-K; other site 527021015846 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 527021015847 Zn2+ binding site [ion binding]; other site 527021015848 Mg2+ binding site [ion binding]; other site 527021015849 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 527021015850 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021015851 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 527021015852 active site 527021015853 metal binding site [ion binding]; metal-binding site 527021015854 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 527021015855 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 527021015856 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 527021015857 active site 527021015858 metal binding site [ion binding]; metal-binding site 527021015859 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 527021015860 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 527021015861 active site 527021015862 PHP Thumb interface [polypeptide binding]; other site 527021015863 metal binding site [ion binding]; metal-binding site 527021015864 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 527021015865 generic binding surface II; other site 527021015866 generic binding surface I; other site 527021015867 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 527021015868 metal ion-dependent adhesion site (MIDAS); other site 527021015869 MoxR-like ATPases [General function prediction only]; Region: COG0714 527021015870 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 527021015871 HerA helicase [Replication, recombination, and repair]; Region: COG0433 527021015872 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 527021015873 Domain of unknown function DUF87; Region: DUF87; pfam01935 527021015874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021015875 Q-loop/lid; other site 527021015876 ABC transporter signature motif; other site 527021015877 Walker B; other site 527021015878 D-loop; other site 527021015879 H-loop/switch region; other site 527021015880 leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300 527021015881 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 527021015882 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 527021015883 DEAD/DEAH box helicase; Region: DEAD; pfam00270 527021015884 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 527021015885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 527021015886 nucleotide binding region [chemical binding]; other site 527021015887 ATP-binding site [chemical binding]; other site 527021015888 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 527021015889 YopX protein; Region: YopX; cl09859 527021015890 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 527021015891 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021015892 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021015893 Bacterial SH3 domain; Region: SH3_3; pfam08239 527021015894 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 527021015895 NlpC/P60 family; Region: NLPC_P60; pfam00877 527021015896 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 527021015897 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 527021015898 N-acetyl-D-glucosamine binding site [chemical binding]; other site 527021015899 catalytic residue [active] 527021015900 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 527021015901 Peptidase family M23; Region: Peptidase_M23; pfam01551 527021015902 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 527021015903 NlpC/P60 family; Region: NLPC_P60; pfam00877 527021015904 AAA-like domain; Region: AAA_10; pfam12846 527021015905 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 527021015906 PrgI family protein; Region: PrgI; pfam12666 527021015907 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 527021015908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021015909 Walker A motif; other site 527021015910 ATP binding site [chemical binding]; other site 527021015911 Walker B motif; other site 527021015912 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 527021015913 Protein of unknown function DUF86; Region: DUF86; cl01031 527021015914 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 527021015915 active site 527021015916 NTP binding site [chemical binding]; other site 527021015917 metal binding triad [ion binding]; metal-binding site 527021015918 antibiotic binding site [chemical binding]; other site 527021015919 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 527021015920 YopX protein; Region: YopX; cl09859 527021015921 translation elongation factor P; Region: efp; TIGR00038 527021015922 Helix-turn-helix domain; Region: HTH_36; pfam13730 527021015923 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 527021015924 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 527021015925 active site 527021015926 catalytic site [active] 527021015927 substrate binding site [chemical binding]; other site 527021015928 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 527021015929 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 527021015930 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 527021015931 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 527021015932 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 527021015933 Fic/DOC family; Region: Fic; cl00960 527021015934 hypothetical protein; Provisional; Region: PRK06922 527021015935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021015936 S-adenosylmethionine binding site [chemical binding]; other site 527021015937 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 527021015938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 527021015939 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 527021015940 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 527021015941 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 527021015942 active site 527021015943 metal binding site [ion binding]; metal-binding site 527021015944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 527021015945 AAA domain; Region: AAA_23; pfam13476 527021015946 Walker A/P-loop; other site 527021015947 ATP binding site [chemical binding]; other site 527021015948 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 527021015949 30S subunit binding site; other site 527021015950 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 527021015951 AAA-like domain; Region: AAA_10; pfam12846 527021015952 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 527021015953 DNA topoisomerase III; Provisional; Region: PRK07726 527021015954 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 527021015955 active site 527021015956 putative interdomain interaction site [polypeptide binding]; other site 527021015957 putative metal-binding site [ion binding]; other site 527021015958 putative nucleotide binding site [chemical binding]; other site 527021015959 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 527021015960 domain I; other site 527021015961 DNA binding groove [nucleotide binding] 527021015962 phosphate binding site [ion binding]; other site 527021015963 domain II; other site 527021015964 domain III; other site 527021015965 nucleotide binding site [chemical binding]; other site 527021015966 catalytic site [active] 527021015967 domain IV; other site 527021015968 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 527021015969 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 527021015970 AAA domain; Region: AAA_30; pfam13604 527021015971 Family description; Region: UvrD_C_2; pfam13538 527021015972 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 527021015973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 527021015974 active site 527021015975 phosphorylation site [posttranslational modification] 527021015976 intermolecular recognition site; other site 527021015977 dimerization interface [polypeptide binding]; other site 527021015978 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 527021015979 RNA binding site [nucleotide binding]; other site 527021015980 DNA polymerase III PolC; Validated; Region: polC; PRK00448 527021015981 thymidylate kinase; Validated; Region: tmk; PRK00698 527021015982 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 527021015983 TMP-binding site; other site 527021015984 ATP-binding site [chemical binding]; other site 527021015985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021015986 non-specific DNA binding site [nucleotide binding]; other site 527021015987 salt bridge; other site 527021015988 sequence-specific DNA binding site [nucleotide binding]; other site 527021015989 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 527021015990 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 527021015991 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 527021015992 DHH family; Region: DHH; pfam01368 527021015993 DHHA1 domain; Region: DHHA1; pfam02272 527021015994 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 527021015995 S-layer homology domain; Region: SLH; pfam00395 527021015996 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 527021015997 putative ADP-ribose binding site [chemical binding]; other site 527021015998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 527021015999 S-adenosylmethionine binding site [chemical binding]; other site 527021016000 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 527021016001 cofactor binding site; other site 527021016002 DNA binding site [nucleotide binding] 527021016003 substrate interaction site [chemical binding]; other site 527021016004 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 527021016005 Replication-relaxation; Region: Replic_Relax; pfam13814 527021016006 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 527021016007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 527021016008 non-specific DNA binding site [nucleotide binding]; other site 527021016009 salt bridge; other site 527021016010 sequence-specific DNA binding site [nucleotide binding]; other site 527021016011 AAA domain; Region: AAA_31; pfam13614 527021016012 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 527021016013 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 527021016014 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 527021016015 B12 binding site [chemical binding]; other site 527021016016 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 527021016017 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 527021016018 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 527021016019 Walker A motif; other site 527021016020 ATP binding site [chemical binding]; other site 527021016021 Walker B motif; other site 527021016022 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 527021016023 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 527021016024 IHF dimer interface [polypeptide binding]; other site 527021016025 IHF - DNA interface [nucleotide binding]; other site 527021016026 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 527021016027 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 527021016028 catalytic residues [active] 527021016029 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 527021016030 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 527021016031 DNA binding residues [nucleotide binding] 527021016032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 527021016033 Integrase core domain; Region: rve; pfam00665 527021016034 transposase/IS protein; Provisional; Region: PRK09183 527021016035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 527021016036 Walker A motif; other site 527021016037 ATP binding site [chemical binding]; other site 527021016038 Walker B motif; other site 527021016039 arginine finger; other site 527021016040 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 527021016041 bacterial Hfq-like; Region: Hfq; cd01716 527021016042 hexamer interface [polypeptide binding]; other site 527021016043 Sm1 motif; other site 527021016044 RNA binding site [nucleotide binding]; other site 527021016045 Sm2 motif; other site 527021016046 Tetratricopeptide repeat; Region: TPR_12; pfam13424 527021016047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 527021016048 TPR motif; other site 527021016049 binding surface 527021016050 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 527021016051 DNA topoisomerase III; Provisional; Region: PRK07726 527021016052 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 527021016053 active site 527021016054 putative interdomain interaction site [polypeptide binding]; other site 527021016055 putative metal-binding site [ion binding]; other site 527021016056 putative nucleotide binding site [chemical binding]; other site 527021016057 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 527021016058 domain I; other site 527021016059 DNA binding groove [nucleotide binding] 527021016060 phosphate binding site [ion binding]; other site 527021016061 domain II; other site 527021016062 domain III; other site 527021016063 nucleotide binding site [chemical binding]; other site 527021016064 catalytic site [active] 527021016065 domain IV; other site 527021016066 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 527021016067 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 527021016068 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 527021016069 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 527021016070 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 527021016071 active site 527021016072 DNA binding site [nucleotide binding] 527021016073 Int/Topo IB signature motif; other site 527021016074 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 527021016075 DNA binding residues [nucleotide binding] 527021016076 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 527021016077 Fic/DOC family; Region: Fic; cl00960 527021016078 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 527021016079 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 527021016080 YopX protein; Region: YopX; pfam09643 527021016081 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 527021016082 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 527021016083 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 527021016084 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 527021016085 Walker A motif; other site 527021016086 ATP binding site [chemical binding]; other site 527021016087 Walker B motif; other site 527021016088 AAA domain; Region: AAA_31; pfam13614 527021016089 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 527021016090 S-layer homology domain; Region: SLH; pfam00395 527021016091 S-layer homology domain; Region: SLH; pfam00395 527021016092 S-layer homology domain; Region: SLH; pfam00395 527021016093 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021016094 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 527021016095 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 527021016096 NlpC/P60 family; Region: NLPC_P60; pfam00877 527021016097 AAA-like domain; Region: AAA_10; pfam12846 527021016098 Domain of unknown function DUF87; Region: DUF87; pfam01935 527021016099 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 527021016100 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 527021016101 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 527021016102 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 527021016103 putative active site [active] 527021016104 putative NTP binding site [chemical binding]; other site 527021016105 putative nucleic acid binding site [nucleotide binding]; other site 527021016106 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 527021016107 active site 527021016108 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 527021016109 Walker A motif; other site 527021016110 ATP binding site [chemical binding]; other site 527021016111 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 527021016112 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 527021016113 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 527021016114 active site 527021016115 DNA binding site [nucleotide binding] 527021016116 Int/Topo IB signature motif; other site 527021016117 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 527021016118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 527021016119 active site 527021016120 DNA binding site [nucleotide binding] 527021016121 Int/Topo IB signature motif; other site 527021016122 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 527021016123 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 527021016124 Mg binding site [ion binding]; other site 527021016125 nucleotide binding site [chemical binding]; other site 527021016126 putative protofilament interface [polypeptide binding]; other site 527021016127 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 527021016128 putative active site [active] 527021016129 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 527021016130 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 527021016131 UDP-glucoronosyl and UDP-glucosyl transferase; Region: UDPGT; pfam00201 527021016132 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 527021016133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 527021016134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 527021016135 DNA binding residues [nucleotide binding] 527021016136 dimerization interface [polypeptide binding]; other site 527021016137 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 527021016138 dimerization interface [polypeptide binding]; other site 527021016139 putative DNA binding site [nucleotide binding]; other site 527021016140 putative Zn2+ binding site [ion binding]; other site 527021016141 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 527021016142 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 527021016143 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 527021016144 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 527021016145 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 527021016146 active site 527021016147 catalytic residues [active] 527021016148 DNA binding site [nucleotide binding] 527021016149 Int/Topo IB signature motif; other site 527021016150 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 527021016151 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 527021016152 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 527021016153 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 527021016154 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 527021016155 DNA binding residues [nucleotide binding] 527021016156 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 527021016157 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 527021016158 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 527021016159 active site 527021016160 catalytic residues [active] 527021016161 DNA binding site [nucleotide binding] 527021016162 Int/Topo IB signature motif; other site 527021016163 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 527021016164 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 527021016165 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 527021016166 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 527021016167 AAA domain; Region: AAA_30; pfam13604 527021016168 Family description; Region: UvrD_C_2; pfam13538 527021016169 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 527021016170 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 527021016171 Replication protein; Region: Rep_1; cl02412 527021016172 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 527021016173 non-specific DNA binding site [nucleotide binding]; other site 527021016174 salt bridge; other site 527021016175 sequence-specific DNA binding site [nucleotide binding]; other site 527021016176 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076