-- dump date 20140618_225619 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1233100000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1233100000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1233100000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100000004 Walker A motif; other site 1233100000005 ATP binding site [chemical binding]; other site 1233100000006 Walker B motif; other site 1233100000007 arginine finger; other site 1233100000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1233100000009 DnaA box-binding interface [nucleotide binding]; other site 1233100000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1233100000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1233100000012 putative DNA binding surface [nucleotide binding]; other site 1233100000013 dimer interface [polypeptide binding]; other site 1233100000014 beta-clamp/clamp loader binding surface; other site 1233100000015 beta-clamp/translesion DNA polymerase binding surface; other site 1233100000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1233100000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1233100000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1233100000019 Walker A/P-loop; other site 1233100000020 ATP binding site [chemical binding]; other site 1233100000021 Q-loop/lid; other site 1233100000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100000023 ABC transporter signature motif; other site 1233100000024 Walker B; other site 1233100000025 D-loop; other site 1233100000026 H-loop/switch region; other site 1233100000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1233100000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100000029 ATP binding site [chemical binding]; other site 1233100000030 Mg2+ binding site [ion binding]; other site 1233100000031 G-X-G motif; other site 1233100000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1233100000033 anchoring element; other site 1233100000034 dimer interface [polypeptide binding]; other site 1233100000035 ATP binding site [chemical binding]; other site 1233100000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1233100000037 active site 1233100000038 putative metal-binding site [ion binding]; other site 1233100000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1233100000040 DNA gyrase subunit A; Validated; Region: PRK05560 1233100000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1233100000042 CAP-like domain; other site 1233100000043 active site 1233100000044 primary dimer interface [polypeptide binding]; other site 1233100000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100000051 YaaC-like Protein; Region: YaaC; pfam14175 1233100000052 YaaC-like Protein; Region: YaaC; pfam14175 1233100000053 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1233100000054 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1233100000055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1233100000056 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1233100000057 active site 1233100000058 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1233100000059 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1233100000060 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1233100000061 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1233100000062 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1233100000063 active site 1233100000064 multimer interface [polypeptide binding]; other site 1233100000065 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1233100000066 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1233100000067 predicted active site [active] 1233100000068 catalytic triad [active] 1233100000069 seryl-tRNA synthetase; Provisional; Region: PRK05431 1233100000070 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1233100000071 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1233100000072 dimer interface [polypeptide binding]; other site 1233100000073 active site 1233100000074 motif 1; other site 1233100000075 motif 2; other site 1233100000076 motif 3; other site 1233100000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1233100000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1233100000079 Substrate-binding site [chemical binding]; other site 1233100000080 Substrate specificity [chemical binding]; other site 1233100000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1233100000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1233100000083 Substrate-binding site [chemical binding]; other site 1233100000084 Substrate specificity [chemical binding]; other site 1233100000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1233100000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1233100000089 active site 1233100000090 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1233100000091 Isochorismatase family; Region: Isochorismatase; pfam00857 1233100000092 catalytic triad [active] 1233100000093 conserved cis-peptide bond; other site 1233100000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1233100000095 nucleoside/Zn binding site; other site 1233100000096 dimer interface [polypeptide binding]; other site 1233100000097 catalytic motif [active] 1233100000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1233100000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100000100 Walker A motif; other site 1233100000101 ATP binding site [chemical binding]; other site 1233100000102 Walker B motif; other site 1233100000103 arginine finger; other site 1233100000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1233100000105 hypothetical protein; Validated; Region: PRK00153 1233100000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 1233100000107 RecR protein; Region: RecR; pfam02132 1233100000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1233100000109 putative active site [active] 1233100000110 putative metal-binding site [ion binding]; other site 1233100000111 tetramer interface [polypeptide binding]; other site 1233100000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1233100000113 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1233100000114 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1233100000115 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 1233100000116 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1233100000117 homodimer interface [polypeptide binding]; other site 1233100000118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100000119 catalytic residue [active] 1233100000120 thymidylate kinase; Validated; Region: tmk; PRK00698 1233100000121 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1233100000122 TMP-binding site; other site 1233100000123 ATP-binding site [chemical binding]; other site 1233100000124 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1233100000125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 1233100000126 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1233100000127 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1233100000128 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1233100000129 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1233100000130 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1233100000131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100000132 S-adenosylmethionine binding site [chemical binding]; other site 1233100000133 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1233100000134 putative metal binding site [ion binding]; other site 1233100000135 Predicted methyltransferases [General function prediction only]; Region: COG0313 1233100000136 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1233100000137 putative homodimer interface [polypeptide binding]; other site 1233100000138 putative SAM binding site [chemical binding]; other site 1233100000139 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1233100000140 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1233100000141 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1233100000142 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1233100000143 active site 1233100000144 HIGH motif; other site 1233100000145 KMSKS motif; other site 1233100000146 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1233100000147 tRNA binding surface [nucleotide binding]; other site 1233100000148 anticodon binding site; other site 1233100000149 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1233100000150 dimer interface [polypeptide binding]; other site 1233100000151 putative tRNA-binding site [nucleotide binding]; other site 1233100000152 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1233100000153 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1233100000154 active site 1233100000155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1233100000156 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1233100000157 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1233100000158 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1233100000159 G5 domain; Region: G5; pfam07501 1233100000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1233100000161 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1233100000162 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1233100000163 putative active site [active] 1233100000164 putative metal binding site [ion binding]; other site 1233100000165 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1233100000166 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1233100000167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100000168 S-adenosylmethionine binding site [chemical binding]; other site 1233100000169 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1233100000170 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1233100000171 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1233100000172 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1233100000173 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1233100000174 pur operon repressor; Provisional; Region: PRK09213 1233100000175 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1233100000176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100000177 active site 1233100000178 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1233100000179 homotrimer interaction site [polypeptide binding]; other site 1233100000180 putative active site [active] 1233100000181 regulatory protein SpoVG; Reviewed; Region: PRK13259 1233100000182 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1233100000183 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1233100000184 Substrate binding site; other site 1233100000185 Mg++ binding site; other site 1233100000186 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1233100000187 active site 1233100000188 substrate binding site [chemical binding]; other site 1233100000189 CoA binding site [chemical binding]; other site 1233100000190 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1233100000191 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1233100000192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100000193 active site 1233100000194 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1233100000195 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1233100000196 5S rRNA interface [nucleotide binding]; other site 1233100000197 CTC domain interface [polypeptide binding]; other site 1233100000198 L16 interface [polypeptide binding]; other site 1233100000199 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1233100000200 putative active site [active] 1233100000201 catalytic residue [active] 1233100000202 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1233100000203 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1233100000204 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1233100000205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100000206 ATP binding site [chemical binding]; other site 1233100000207 putative Mg++ binding site [ion binding]; other site 1233100000208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100000209 nucleotide binding region [chemical binding]; other site 1233100000210 ATP-binding site [chemical binding]; other site 1233100000211 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1233100000212 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1233100000213 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1233100000214 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1233100000215 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1233100000216 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1233100000217 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1233100000218 putative SAM binding site [chemical binding]; other site 1233100000219 putative homodimer interface [polypeptide binding]; other site 1233100000220 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1233100000221 homodimer interface [polypeptide binding]; other site 1233100000222 metal binding site [ion binding]; metal-binding site 1233100000223 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1233100000224 homodimer interface [polypeptide binding]; other site 1233100000225 active site 1233100000226 putative chemical substrate binding site [chemical binding]; other site 1233100000227 metal binding site [ion binding]; metal-binding site 1233100000228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233100000229 RNA binding surface [nucleotide binding]; other site 1233100000230 sporulation protein YabP; Region: spore_yabP; TIGR02892 1233100000231 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1233100000232 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1233100000233 Septum formation initiator; Region: DivIC; pfam04977 1233100000234 hypothetical protein; Provisional; Region: PRK08582 1233100000235 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1233100000236 RNA binding site [nucleotide binding]; other site 1233100000237 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1233100000238 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1233100000239 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1233100000240 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1233100000241 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1233100000242 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1233100000243 metal ion-dependent adhesion site (MIDAS); other site 1233100000244 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1233100000245 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1233100000246 active site 1233100000247 ATP binding site [chemical binding]; other site 1233100000248 substrate binding site [chemical binding]; other site 1233100000249 activation loop (A-loop); other site 1233100000250 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1233100000251 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1233100000252 Ligand Binding Site [chemical binding]; other site 1233100000253 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1233100000254 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100000255 active site 1233100000256 FtsH Extracellular; Region: FtsH_ext; pfam06480 1233100000257 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1233100000258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100000259 Walker A motif; other site 1233100000260 ATP binding site [chemical binding]; other site 1233100000261 Walker B motif; other site 1233100000262 arginine finger; other site 1233100000263 Peptidase family M41; Region: Peptidase_M41; pfam01434 1233100000264 pantothenate kinase; Reviewed; Region: PRK13318 1233100000265 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1233100000266 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1233100000267 dimerization interface [polypeptide binding]; other site 1233100000268 domain crossover interface; other site 1233100000269 redox-dependent activation switch; other site 1233100000270 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1233100000271 SurA N-terminal domain; Region: SurA_N_3; cl07813 1233100000272 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1233100000273 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1233100000274 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1233100000275 dimer interface [polypeptide binding]; other site 1233100000276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100000277 catalytic residue [active] 1233100000278 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1233100000279 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1233100000280 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1233100000281 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1233100000282 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1233100000283 glutamine binding [chemical binding]; other site 1233100000284 catalytic triad [active] 1233100000285 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1233100000286 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1233100000287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100000288 catalytic residue [active] 1233100000289 dihydropteroate synthase; Region: DHPS; TIGR01496 1233100000290 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1233100000291 substrate binding pocket [chemical binding]; other site 1233100000292 dimer interface [polypeptide binding]; other site 1233100000293 inhibitor binding site; inhibition site 1233100000294 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1233100000295 homooctamer interface [polypeptide binding]; other site 1233100000296 active site 1233100000297 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1233100000298 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1233100000299 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1233100000300 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1233100000301 FMN binding site [chemical binding]; other site 1233100000302 active site 1233100000303 catalytic residues [active] 1233100000304 substrate binding site [chemical binding]; other site 1233100000305 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1233100000306 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1233100000307 dimer interface [polypeptide binding]; other site 1233100000308 putative anticodon binding site; other site 1233100000309 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1233100000310 motif 1; other site 1233100000311 active site 1233100000312 motif 2; other site 1233100000313 motif 3; other site 1233100000314 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1233100000315 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1233100000316 UvrB/uvrC motif; Region: UVR; pfam02151 1233100000317 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1233100000318 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1233100000319 ADP binding site [chemical binding]; other site 1233100000320 phosphagen binding site; other site 1233100000321 substrate specificity loop; other site 1233100000322 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1233100000323 Clp amino terminal domain; Region: Clp_N; pfam02861 1233100000324 Clp amino terminal domain; Region: Clp_N; pfam02861 1233100000325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100000326 Walker A motif; other site 1233100000327 ATP binding site [chemical binding]; other site 1233100000328 Walker B motif; other site 1233100000329 arginine finger; other site 1233100000330 UvrB/uvrC motif; Region: UVR; pfam02151 1233100000331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100000332 Walker A motif; other site 1233100000333 ATP binding site [chemical binding]; other site 1233100000334 Walker B motif; other site 1233100000335 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1233100000336 DNA repair protein RadA; Provisional; Region: PRK11823 1233100000337 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1233100000338 Walker A motif/ATP binding site; other site 1233100000339 ATP binding site [chemical binding]; other site 1233100000340 Walker B motif; other site 1233100000341 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1233100000342 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1233100000343 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1233100000344 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1233100000345 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1233100000346 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1233100000347 putative active site [active] 1233100000348 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1233100000349 substrate binding site; other site 1233100000350 dimer interface; other site 1233100000351 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1233100000352 homotrimer interaction site [polypeptide binding]; other site 1233100000353 zinc binding site [ion binding]; other site 1233100000354 CDP-binding sites; other site 1233100000355 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1233100000356 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1233100000357 active site 1233100000358 HIGH motif; other site 1233100000359 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1233100000360 active site 1233100000361 KMSKS motif; other site 1233100000362 serine O-acetyltransferase; Region: cysE; TIGR01172 1233100000363 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1233100000364 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1233100000365 trimer interface [polypeptide binding]; other site 1233100000366 active site 1233100000367 substrate binding site [chemical binding]; other site 1233100000368 CoA binding site [chemical binding]; other site 1233100000369 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1233100000370 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1233100000371 active site 1233100000372 HIGH motif; other site 1233100000373 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1233100000374 KMSKS motif; other site 1233100000375 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1233100000376 tRNA binding surface [nucleotide binding]; other site 1233100000377 anticodon binding site; other site 1233100000378 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1233100000379 active site 1233100000380 metal binding site [ion binding]; metal-binding site 1233100000381 dimerization interface [polypeptide binding]; other site 1233100000382 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1233100000383 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1233100000384 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1233100000385 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1233100000386 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1233100000387 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100000388 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1233100000389 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1233100000390 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1233100000391 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1233100000392 putative homodimer interface [polypeptide binding]; other site 1233100000393 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1233100000394 heterodimer interface [polypeptide binding]; other site 1233100000395 homodimer interface [polypeptide binding]; other site 1233100000396 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1233100000397 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1233100000398 L7/L12 interface [polypeptide binding]; other site 1233100000399 23S rRNA interface [nucleotide binding]; other site 1233100000400 L25 interface [polypeptide binding]; other site 1233100000401 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1233100000402 mRNA/rRNA interface [nucleotide binding]; other site 1233100000403 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1233100000404 23S rRNA interface [nucleotide binding]; other site 1233100000405 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1233100000406 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1233100000407 core dimer interface [polypeptide binding]; other site 1233100000408 peripheral dimer interface [polypeptide binding]; other site 1233100000409 L10 interface [polypeptide binding]; other site 1233100000410 L11 interface [polypeptide binding]; other site 1233100000411 putative EF-Tu interaction site [polypeptide binding]; other site 1233100000412 putative EF-G interaction site [polypeptide binding]; other site 1233100000413 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1233100000414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100000415 S-adenosylmethionine binding site [chemical binding]; other site 1233100000416 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1233100000417 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1233100000418 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1233100000419 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1233100000420 RPB1 interaction site [polypeptide binding]; other site 1233100000421 RPB10 interaction site [polypeptide binding]; other site 1233100000422 RPB11 interaction site [polypeptide binding]; other site 1233100000423 RPB3 interaction site [polypeptide binding]; other site 1233100000424 RPB12 interaction site [polypeptide binding]; other site 1233100000425 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1233100000426 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1233100000427 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1233100000428 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1233100000429 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1233100000430 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1233100000431 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1233100000432 G-loop; other site 1233100000433 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1233100000434 DNA binding site [nucleotide binding] 1233100000435 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1233100000436 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1233100000437 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1233100000438 streptomycin interaction site [chemical binding]; other site 1233100000439 23S rRNA interaction site [nucleotide binding]; other site 1233100000440 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1233100000441 16S rRNA interaction site [nucleotide binding]; other site 1233100000442 30S ribosomal protein S7; Validated; Region: PRK05302 1233100000443 elongation factor G; Reviewed; Region: PRK00007 1233100000444 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1233100000445 Switch I region; other site 1233100000446 G2 box; other site 1233100000447 putative GEF interaction site [polypeptide binding]; other site 1233100000448 G3 box; other site 1233100000449 Switch II region; other site 1233100000450 GTP/Mg2+ binding site [chemical binding]; other site 1233100000451 G4 box; other site 1233100000452 G5 box; other site 1233100000453 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1233100000454 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1233100000455 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1233100000456 elongation factor Tu; Reviewed; Region: PRK00049 1233100000457 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1233100000458 G1 box; other site 1233100000459 GEF interaction site [polypeptide binding]; other site 1233100000460 GTP/Mg2+ binding site [chemical binding]; other site 1233100000461 Switch I region; other site 1233100000462 G2 box; other site 1233100000463 G3 box; other site 1233100000464 Switch II region; other site 1233100000465 G4 box; other site 1233100000466 G5 box; other site 1233100000467 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1233100000468 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1233100000469 Antibiotic Binding Site [chemical binding]; other site 1233100000470 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100000471 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1233100000472 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1233100000473 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1233100000474 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1233100000475 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1233100000476 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1233100000477 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1233100000478 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1233100000479 protein-rRNA interface [nucleotide binding]; other site 1233100000480 putative translocon binding site; other site 1233100000481 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1233100000482 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1233100000483 G-X-X-G motif; other site 1233100000484 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1233100000485 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1233100000486 L27 interface [polypeptide binding]; other site 1233100000487 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1233100000488 23S rRNA interface [nucleotide binding]; other site 1233100000489 putative translocon interaction site; other site 1233100000490 signal recognition particle (SRP54) interaction site; other site 1233100000491 L23 interface [polypeptide binding]; other site 1233100000492 trigger factor interaction site; other site 1233100000493 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1233100000494 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1233100000495 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1233100000496 RNA binding site [nucleotide binding]; other site 1233100000497 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1233100000498 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1233100000499 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1233100000500 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1233100000501 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1233100000502 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1233100000503 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1233100000504 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1233100000505 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1233100000506 23S rRNA interface [nucleotide binding]; other site 1233100000507 L5 interface [polypeptide binding]; other site 1233100000508 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1233100000509 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1233100000510 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1233100000511 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1233100000512 23S rRNA binding site [nucleotide binding]; other site 1233100000513 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1233100000514 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1233100000515 SecY translocase; Region: SecY; pfam00344 1233100000516 adenylate kinase; Reviewed; Region: adk; PRK00279 1233100000517 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1233100000518 AMP-binding site [chemical binding]; other site 1233100000519 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1233100000520 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1233100000521 active site 1233100000522 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1233100000523 RNA binding site [nucleotide binding]; other site 1233100000524 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1233100000525 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1233100000526 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1233100000527 30S ribosomal protein S11; Validated; Region: PRK05309 1233100000528 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1233100000529 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1233100000530 alphaNTD homodimer interface [polypeptide binding]; other site 1233100000531 alphaNTD - beta interaction site [polypeptide binding]; other site 1233100000532 alphaNTD - beta' interaction site [polypeptide binding]; other site 1233100000533 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1233100000534 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1233100000535 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1233100000536 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233100000537 Walker A/P-loop; other site 1233100000538 ATP binding site [chemical binding]; other site 1233100000539 Q-loop/lid; other site 1233100000540 ABC transporter signature motif; other site 1233100000541 Walker B; other site 1233100000542 D-loop; other site 1233100000543 H-loop/switch region; other site 1233100000544 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1233100000545 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233100000546 Walker A/P-loop; other site 1233100000547 ATP binding site [chemical binding]; other site 1233100000548 Q-loop/lid; other site 1233100000549 ABC transporter signature motif; other site 1233100000550 Walker B; other site 1233100000551 D-loop; other site 1233100000552 H-loop/switch region; other site 1233100000553 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1233100000554 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1233100000555 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1233100000556 dimerization interface 3.5A [polypeptide binding]; other site 1233100000557 active site 1233100000558 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1233100000559 23S rRNA interface [nucleotide binding]; other site 1233100000560 L3 interface [polypeptide binding]; other site 1233100000561 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1233100000562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100000563 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1233100000564 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1233100000565 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1233100000566 active site 1233100000567 metal binding site [ion binding]; metal-binding site 1233100000568 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1233100000569 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1233100000570 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1233100000571 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1233100000572 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1233100000573 NodB motif; other site 1233100000574 putative active site [active] 1233100000575 putative catalytic site [active] 1233100000576 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1233100000577 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1233100000578 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1233100000579 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1233100000580 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1233100000581 Sodium Bile acid symporter family; Region: SBF; cl17470 1233100000582 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1233100000583 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1233100000584 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100000585 dimer interface [polypeptide binding]; other site 1233100000586 putative PBP binding regions; other site 1233100000587 ABC-ATPase subunit interface; other site 1233100000588 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233100000589 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1233100000590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100000591 ABC-ATPase subunit interface; other site 1233100000592 dimer interface [polypeptide binding]; other site 1233100000593 putative PBP binding regions; other site 1233100000594 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1233100000595 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1233100000596 putative ligand binding residues [chemical binding]; other site 1233100000597 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233100000598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100000599 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1233100000600 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1233100000601 putative ligand binding residues [chemical binding]; other site 1233100000602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 1233100000603 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1233100000604 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1233100000605 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1233100000606 putative periplasmic esterase; Provisional; Region: PRK03642 1233100000607 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1233100000608 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1233100000609 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233100000610 active site turn [active] 1233100000611 phosphorylation site [posttranslational modification] 1233100000612 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233100000613 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1233100000614 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1233100000615 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1233100000616 putative active site [active] 1233100000617 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 1233100000618 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1233100000619 putative active site [active] 1233100000620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1233100000621 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1233100000622 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1233100000623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100000624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100000625 DNA binding residues [nucleotide binding] 1233100000626 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1233100000627 Putative zinc-finger; Region: zf-HC2; pfam13490 1233100000628 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1233100000629 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1233100000630 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1233100000631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1233100000632 YbbR-like protein; Region: YbbR; pfam07949 1233100000633 YbbR-like protein; Region: YbbR; pfam07949 1233100000634 YbbR-like protein; Region: YbbR; pfam07949 1233100000635 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1233100000636 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1233100000637 active site 1233100000638 substrate binding site [chemical binding]; other site 1233100000639 metal binding site [ion binding]; metal-binding site 1233100000640 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1233100000641 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1233100000642 glutaminase active site [active] 1233100000643 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1233100000644 dimer interface [polypeptide binding]; other site 1233100000645 active site 1233100000646 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1233100000647 dimer interface [polypeptide binding]; other site 1233100000648 active site 1233100000649 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1233100000650 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1233100000651 active site 1233100000652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1233100000653 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1233100000654 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1233100000655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100000656 dimerization interface [polypeptide binding]; other site 1233100000657 putative DNA binding site [nucleotide binding]; other site 1233100000658 putative Zn2+ binding site [ion binding]; other site 1233100000659 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1233100000660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000661 putative substrate translocation pore; other site 1233100000662 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1233100000663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100000664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100000665 active site 1233100000666 phosphorylation site [posttranslational modification] 1233100000667 intermolecular recognition site; other site 1233100000668 dimerization interface [polypeptide binding]; other site 1233100000669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100000670 DNA binding site [nucleotide binding] 1233100000671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100000672 HAMP domain; Region: HAMP; pfam00672 1233100000673 dimerization interface [polypeptide binding]; other site 1233100000674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100000675 dimer interface [polypeptide binding]; other site 1233100000676 phosphorylation site [posttranslational modification] 1233100000677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100000678 ATP binding site [chemical binding]; other site 1233100000679 Mg2+ binding site [ion binding]; other site 1233100000680 G-X-G motif; other site 1233100000681 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1233100000682 active site 1233100000683 ATP binding site [chemical binding]; other site 1233100000684 substrate binding site [chemical binding]; other site 1233100000685 activation loop (A-loop); other site 1233100000686 putative transport protein YifK; Provisional; Region: PRK10746 1233100000687 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1233100000688 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1233100000689 Cytochrome P450; Region: p450; cl12078 1233100000690 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1233100000691 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1233100000692 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1233100000693 active site 1233100000694 catalytic site [active] 1233100000695 metal binding site [ion binding]; metal-binding site 1233100000696 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1233100000697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000698 putative substrate translocation pore; other site 1233100000699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000700 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1233100000701 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100000702 MarR family; Region: MarR; pfam01047 1233100000703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1233100000704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100000705 Coenzyme A binding pocket [chemical binding]; other site 1233100000706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100000708 putative substrate translocation pore; other site 1233100000709 EamA-like transporter family; Region: EamA; pfam00892 1233100000710 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1233100000711 EamA-like transporter family; Region: EamA; pfam00892 1233100000712 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1233100000713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100000714 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233100000715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100000716 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1233100000717 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1233100000718 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233100000719 ATP-grasp domain; Region: ATP-grasp; pfam02222 1233100000720 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1233100000721 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1233100000722 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100000723 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1233100000724 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1233100000725 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1233100000726 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233100000727 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1233100000728 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1233100000729 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1233100000730 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1233100000731 active site residue [active] 1233100000732 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1233100000733 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1233100000734 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1233100000735 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 1233100000736 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233100000737 active site turn [active] 1233100000738 phosphorylation site [posttranslational modification] 1233100000739 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1233100000740 HPr interaction site; other site 1233100000741 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1233100000742 active site 1233100000743 phosphorylation site [posttranslational modification] 1233100000744 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1233100000745 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1233100000746 active site 1233100000747 trimer interface [polypeptide binding]; other site 1233100000748 allosteric site; other site 1233100000749 active site lid [active] 1233100000750 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1233100000751 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233100000752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100000753 DNA-binding site [nucleotide binding]; DNA binding site 1233100000754 UTRA domain; Region: UTRA; pfam07702 1233100000755 Predicted integral membrane protein [Function unknown]; Region: COG5658 1233100000756 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1233100000757 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1233100000758 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1233100000759 homodimer interface [polypeptide binding]; other site 1233100000760 substrate-cofactor binding pocket; other site 1233100000761 catalytic residue [active] 1233100000762 S-methylmethionine transporter; Provisional; Region: PRK11387 1233100000763 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1233100000764 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1233100000765 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1233100000766 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1233100000767 glutaminase; Reviewed; Region: PRK12357 1233100000768 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1233100000769 Chorismate mutase type II; Region: CM_2; cl00693 1233100000770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100000771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100000772 ATP binding site [chemical binding]; other site 1233100000773 Mg2+ binding site [ion binding]; other site 1233100000774 G-X-G motif; other site 1233100000775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100000776 Response regulator receiver domain; Region: Response_reg; pfam00072 1233100000777 active site 1233100000778 phosphorylation site [posttranslational modification] 1233100000779 intermolecular recognition site; other site 1233100000780 dimerization interface [polypeptide binding]; other site 1233100000781 YcbB domain; Region: YcbB; pfam08664 1233100000782 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1233100000783 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1233100000784 putative active site [active] 1233100000785 catalytic residue [active] 1233100000786 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1233100000787 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233100000788 NAD(P) binding site [chemical binding]; other site 1233100000789 catalytic residues [active] 1233100000790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000791 D-galactonate transporter; Region: 2A0114; TIGR00893 1233100000792 putative substrate translocation pore; other site 1233100000793 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1233100000794 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1233100000795 active site 1233100000796 tetramer interface [polypeptide binding]; other site 1233100000797 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1233100000798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100000799 DNA-binding site [nucleotide binding]; DNA binding site 1233100000800 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1233100000801 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1233100000802 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1233100000803 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1233100000804 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1233100000805 putative active site [active] 1233100000806 putative substrate binding site [chemical binding]; other site 1233100000807 Phosphotransferase enzyme family; Region: APH; pfam01636 1233100000808 ATP binding site [chemical binding]; other site 1233100000809 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1233100000810 dodecamer interface 1 [polypeptide binding]; other site 1233100000811 dodecamer interface 2 [polypeptide binding]; other site 1233100000812 trimer interface [polypeptide binding]; other site 1233100000813 TRAP binding interface [polypeptide binding]; other site 1233100000814 Zn binding site [ion binding]; other site 1233100000815 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1233100000816 EamA-like transporter family; Region: EamA; pfam00892 1233100000817 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100000818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100000819 active site 1233100000820 phosphorylation site [posttranslational modification] 1233100000821 intermolecular recognition site; other site 1233100000822 dimerization interface [polypeptide binding]; other site 1233100000823 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100000824 DNA binding site [nucleotide binding] 1233100000825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100000826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100000827 dimer interface [polypeptide binding]; other site 1233100000828 phosphorylation site [posttranslational modification] 1233100000829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100000830 ATP binding site [chemical binding]; other site 1233100000831 Mg2+ binding site [ion binding]; other site 1233100000832 G-X-G motif; other site 1233100000833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1233100000834 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1233100000835 Walker A/P-loop; other site 1233100000836 ATP binding site [chemical binding]; other site 1233100000837 Q-loop/lid; other site 1233100000838 ABC transporter signature motif; other site 1233100000839 Walker B; other site 1233100000840 D-loop; other site 1233100000841 H-loop/switch region; other site 1233100000842 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1233100000843 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1233100000844 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1233100000845 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1233100000846 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1233100000847 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1233100000848 metal ion-dependent adhesion site (MIDAS); other site 1233100000849 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1233100000850 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1233100000851 putative active site [active] 1233100000852 putative metal binding site [ion binding]; other site 1233100000853 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1233100000854 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1233100000855 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1233100000856 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1233100000857 putative substrate binding pocket [chemical binding]; other site 1233100000858 AC domain interface; other site 1233100000859 catalytic triad [active] 1233100000860 AB domain interface; other site 1233100000861 interchain disulfide; other site 1233100000862 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1233100000863 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1233100000864 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233100000865 catalytic residue [active] 1233100000866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100000868 putative substrate translocation pore; other site 1233100000869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000870 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100000871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100000872 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1233100000873 active site 1233100000874 homotetramer interface [polypeptide binding]; other site 1233100000875 homodimer interface [polypeptide binding]; other site 1233100000876 Lipase (class 2); Region: Lipase_2; pfam01674 1233100000877 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1233100000878 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1233100000879 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1233100000880 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1233100000881 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1233100000882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100000883 active site 1233100000884 phosphorylation site [posttranslational modification] 1233100000885 intermolecular recognition site; other site 1233100000886 dimerization interface [polypeptide binding]; other site 1233100000887 LytTr DNA-binding domain; Region: LytTR; pfam04397 1233100000888 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1233100000889 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 1233100000890 Walker A/P-loop; other site 1233100000891 ATP binding site [chemical binding]; other site 1233100000892 Q-loop/lid; other site 1233100000893 ABC transporter signature motif; other site 1233100000894 Walker B; other site 1233100000895 D-loop; other site 1233100000896 H-loop/switch region; other site 1233100000897 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1233100000898 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1233100000899 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233100000900 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233100000901 active site 1233100000902 catalytic tetrad [active] 1233100000903 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1233100000904 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1233100000905 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1233100000906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1233100000907 binding surface 1233100000908 TPR motif; other site 1233100000909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233100000910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100000911 binding surface 1233100000912 TPR motif; other site 1233100000913 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1233100000914 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1233100000915 NAD binding site [chemical binding]; other site 1233100000916 homodimer interface [polypeptide binding]; other site 1233100000917 active site 1233100000918 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1233100000919 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1233100000920 Ca binding site [ion binding]; other site 1233100000921 active site 1233100000922 catalytic site [active] 1233100000923 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1233100000924 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1233100000925 metal binding site [ion binding]; metal-binding site 1233100000926 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1233100000927 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100000928 ABC-ATPase subunit interface; other site 1233100000929 dimer interface [polypeptide binding]; other site 1233100000930 putative PBP binding regions; other site 1233100000931 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1233100000932 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1233100000933 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1233100000934 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1233100000935 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1233100000936 putative metal binding site [ion binding]; other site 1233100000937 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1233100000938 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1233100000939 putative metal binding site [ion binding]; other site 1233100000940 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1233100000941 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1233100000942 putative metal binding site [ion binding]; other site 1233100000943 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1233100000944 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1233100000945 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1233100000946 benzoate transport; Region: 2A0115; TIGR00895 1233100000947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000948 putative substrate translocation pore; other site 1233100000949 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1233100000950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000951 putative substrate translocation pore; other site 1233100000952 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100000953 dimerization interface [polypeptide binding]; other site 1233100000954 putative DNA binding site [nucleotide binding]; other site 1233100000955 putative Zn2+ binding site [ion binding]; other site 1233100000956 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1233100000957 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1233100000958 Walker A/P-loop; other site 1233100000959 ATP binding site [chemical binding]; other site 1233100000960 Q-loop/lid; other site 1233100000961 ABC transporter signature motif; other site 1233100000962 Walker B; other site 1233100000963 D-loop; other site 1233100000964 H-loop/switch region; other site 1233100000965 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1233100000966 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1233100000967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100000968 dimer interface [polypeptide binding]; other site 1233100000969 conserved gate region; other site 1233100000970 putative PBP binding loops; other site 1233100000971 ABC-ATPase subunit interface; other site 1233100000972 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1233100000973 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1233100000974 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1233100000975 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1233100000976 amidohydrolase; Region: amidohydrolases; TIGR01891 1233100000977 metal binding site [ion binding]; metal-binding site 1233100000978 putative dimer interface [polypeptide binding]; other site 1233100000979 Predicted membrane protein [Function unknown]; Region: COG1288 1233100000980 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1233100000981 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1233100000982 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1233100000983 active site 1233100000984 Ca binding site [ion binding]; other site 1233100000985 catalytic site [active] 1233100000986 Aamy_C domain; Region: Aamy_C; smart00632 1233100000987 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1233100000988 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1233100000989 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233100000990 NAD binding site [chemical binding]; other site 1233100000991 dimer interface [polypeptide binding]; other site 1233100000992 substrate binding site [chemical binding]; other site 1233100000993 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1233100000994 L-lactate permease; Region: Lactate_perm; pfam02652 1233100000995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000996 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100000997 putative substrate translocation pore; other site 1233100000998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100000999 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100001000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100001001 putative DNA binding site [nucleotide binding]; other site 1233100001002 putative Zn2+ binding site [ion binding]; other site 1233100001003 LysE type translocator; Region: LysE; pfam01810 1233100001004 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1233100001005 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1233100001006 Spore germination protein; Region: Spore_permease; cl17796 1233100001007 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1233100001008 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1233100001009 NAD+ synthetase; Region: nadE; TIGR00552 1233100001010 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1233100001011 homodimer interface [polypeptide binding]; other site 1233100001012 NAD binding pocket [chemical binding]; other site 1233100001013 ATP binding pocket [chemical binding]; other site 1233100001014 Mg binding site [ion binding]; other site 1233100001015 active-site loop [active] 1233100001016 AAA domain; Region: AAA_17; cl17253 1233100001017 AAA domain; Region: AAA_18; pfam13238 1233100001018 shikimate kinase; Reviewed; Region: aroK; PRK00131 1233100001019 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1233100001020 ADP binding site [chemical binding]; other site 1233100001021 magnesium binding site [ion binding]; other site 1233100001022 putative shikimate binding site; other site 1233100001023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100001024 S-adenosylmethionine binding site [chemical binding]; other site 1233100001025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100001026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100001027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233100001028 dimerization interface [polypeptide binding]; other site 1233100001029 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1233100001030 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1233100001031 Proline dehydrogenase; Region: Pro_dh; pfam01619 1233100001032 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1233100001033 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1233100001034 Glutamate binding site [chemical binding]; other site 1233100001035 homodimer interface [polypeptide binding]; other site 1233100001036 NAD binding site [chemical binding]; other site 1233100001037 catalytic residues [active] 1233100001038 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1233100001039 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1233100001040 Na binding site [ion binding]; other site 1233100001041 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1233100001042 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233100001043 Predicted membrane protein [Function unknown]; Region: COG3689 1233100001044 Predicted permeases [General function prediction only]; Region: COG0701 1233100001045 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100001046 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1233100001047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233100001048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100001049 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1233100001050 active site 1233100001051 SAM binding site [chemical binding]; other site 1233100001052 homodimer interface [polypeptide binding]; other site 1233100001053 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1233100001054 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1233100001055 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1233100001056 [2Fe-2S] cluster binding site [ion binding]; other site 1233100001057 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1233100001058 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100001059 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1233100001060 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1233100001061 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1233100001062 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1233100001063 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1233100001064 [4Fe-4S] binding site [ion binding]; other site 1233100001065 molybdopterin cofactor binding site; other site 1233100001066 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1233100001067 molybdopterin cofactor binding site; other site 1233100001068 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1233100001069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100001070 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1233100001071 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1233100001072 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1233100001073 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1233100001074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001075 putative substrate translocation pore; other site 1233100001076 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1233100001077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1233100001078 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1233100001079 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1233100001080 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1233100001081 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1233100001082 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1233100001083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100001084 dimer interface [polypeptide binding]; other site 1233100001085 conserved gate region; other site 1233100001086 putative PBP binding loops; other site 1233100001087 ABC-ATPase subunit interface; other site 1233100001088 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1233100001089 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233100001090 substrate binding pocket [chemical binding]; other site 1233100001091 membrane-bound complex binding site; other site 1233100001092 hinge residues; other site 1233100001093 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1233100001094 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1233100001095 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1233100001096 beta-galactosidase; Region: BGL; TIGR03356 1233100001097 Competence protein J (ComJ); Region: ComJ; pfam11033 1233100001098 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1233100001099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100001100 dimerization interface [polypeptide binding]; other site 1233100001101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100001102 dimer interface [polypeptide binding]; other site 1233100001103 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1233100001104 putative CheW interface [polypeptide binding]; other site 1233100001105 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1233100001106 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1233100001107 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1233100001108 active site 1233100001109 dimer interface [polypeptide binding]; other site 1233100001110 magnesium binding site [ion binding]; other site 1233100001111 Predicted transcriptional regulators [Transcription]; Region: COG1733 1233100001112 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1233100001113 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1233100001114 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1233100001115 Condensation domain; Region: Condensation; pfam00668 1233100001116 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1233100001117 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1233100001118 acyl-activating enzyme (AAE) consensus motif; other site 1233100001119 AMP binding site [chemical binding]; other site 1233100001120 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100001121 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1233100001122 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1233100001123 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1233100001124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100001126 putative substrate translocation pore; other site 1233100001127 YcxB-like protein; Region: YcxB; pfam14317 1233100001128 EamA-like transporter family; Region: EamA; pfam00892 1233100001129 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1233100001130 EamA-like transporter family; Region: EamA; pfam00892 1233100001131 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1233100001132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100001133 DNA-binding site [nucleotide binding]; DNA binding site 1233100001134 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100001135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100001136 homodimer interface [polypeptide binding]; other site 1233100001137 catalytic residue [active] 1233100001138 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1233100001139 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1233100001140 Predicted membrane protein [Function unknown]; Region: COG2364 1233100001141 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100001142 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1233100001143 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1233100001144 Walker A/P-loop; other site 1233100001145 ATP binding site [chemical binding]; other site 1233100001146 Q-loop/lid; other site 1233100001147 ABC transporter signature motif; other site 1233100001148 Walker B; other site 1233100001149 D-loop; other site 1233100001150 H-loop/switch region; other site 1233100001151 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1233100001152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100001153 dimer interface [polypeptide binding]; other site 1233100001154 conserved gate region; other site 1233100001155 putative PBP binding loops; other site 1233100001156 ABC-ATPase subunit interface; other site 1233100001157 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1233100001158 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233100001159 substrate binding pocket [chemical binding]; other site 1233100001160 membrane-bound complex binding site; other site 1233100001161 hinge residues; other site 1233100001162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100001163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100001164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233100001165 dimerization interface [polypeptide binding]; other site 1233100001166 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 1233100001167 Flavoprotein; Region: Flavoprotein; pfam02441 1233100001168 UbiD family decarboxylase; Region: TIGR00148 1233100001169 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1233100001170 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100001171 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1233100001172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001173 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1233100001174 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1233100001175 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233100001176 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1233100001177 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1233100001178 Spore germination protein; Region: Spore_permease; pfam03845 1233100001179 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1233100001180 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1233100001181 Walker A/P-loop; other site 1233100001182 ATP binding site [chemical binding]; other site 1233100001183 Q-loop/lid; other site 1233100001184 ABC transporter signature motif; other site 1233100001185 Walker B; other site 1233100001186 D-loop; other site 1233100001187 H-loop/switch region; other site 1233100001188 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1233100001189 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1233100001190 FtsX-like permease family; Region: FtsX; pfam02687 1233100001191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100001192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100001193 active site 1233100001194 phosphorylation site [posttranslational modification] 1233100001195 intermolecular recognition site; other site 1233100001196 dimerization interface [polypeptide binding]; other site 1233100001197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100001198 DNA binding site [nucleotide binding] 1233100001199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100001200 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100001201 dimerization interface [polypeptide binding]; other site 1233100001202 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100001203 dimer interface [polypeptide binding]; other site 1233100001204 phosphorylation site [posttranslational modification] 1233100001205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100001206 ATP binding site [chemical binding]; other site 1233100001207 Mg2+ binding site [ion binding]; other site 1233100001208 G-X-G motif; other site 1233100001209 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233100001210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100001211 TPR motif; other site 1233100001212 binding surface 1233100001213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233100001214 aspartate kinase; Reviewed; Region: PRK09034 1233100001215 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1233100001216 putative catalytic residues [active] 1233100001217 putative nucleotide binding site [chemical binding]; other site 1233100001218 putative aspartate binding site [chemical binding]; other site 1233100001219 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1233100001220 allosteric regulatory residue; other site 1233100001221 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1233100001222 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1233100001223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100001224 ABC-ATPase subunit interface; other site 1233100001225 dimer interface [polypeptide binding]; other site 1233100001226 putative PBP binding regions; other site 1233100001227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100001228 ABC-ATPase subunit interface; other site 1233100001229 dimer interface [polypeptide binding]; other site 1233100001230 putative PBP binding regions; other site 1233100001231 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1233100001232 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1233100001233 Walker A/P-loop; other site 1233100001234 ATP binding site [chemical binding]; other site 1233100001235 Q-loop/lid; other site 1233100001236 ABC transporter signature motif; other site 1233100001237 Walker B; other site 1233100001238 D-loop; other site 1233100001239 H-loop/switch region; other site 1233100001240 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1233100001241 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1233100001242 putative ligand binding residues [chemical binding]; other site 1233100001243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100001245 putative substrate translocation pore; other site 1233100001246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100001248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100001249 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1233100001250 dimer interface [polypeptide binding]; other site 1233100001251 FMN binding site [chemical binding]; other site 1233100001252 NADPH bind site [chemical binding]; other site 1233100001253 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1233100001254 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100001255 dimerization interface [polypeptide binding]; other site 1233100001256 putative DNA binding site [nucleotide binding]; other site 1233100001257 putative Zn2+ binding site [ion binding]; other site 1233100001258 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1233100001259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100001260 DNA-binding site [nucleotide binding]; DNA binding site 1233100001261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100001262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100001263 homodimer interface [polypeptide binding]; other site 1233100001264 catalytic residue [active] 1233100001265 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1233100001266 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233100001267 inhibitor-cofactor binding pocket; inhibition site 1233100001268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100001269 catalytic residue [active] 1233100001270 succinic semialdehyde dehydrogenase; Region: PLN02278 1233100001271 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1233100001272 tetramerization interface [polypeptide binding]; other site 1233100001273 NAD(P) binding site [chemical binding]; other site 1233100001274 catalytic residues [active] 1233100001275 Sugar transport protein; Region: Sugar_transport; pfam06800 1233100001276 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1233100001277 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1233100001278 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1233100001279 NAD binding site [chemical binding]; other site 1233100001280 homodimer interface [polypeptide binding]; other site 1233100001281 active site 1233100001282 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1233100001283 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1233100001284 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1233100001285 YtkA-like; Region: YtkA; pfam13115 1233100001286 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1233100001287 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1233100001288 NosL; Region: NosL; cl01769 1233100001289 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1233100001290 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1233100001291 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1233100001292 active site 1233100001293 P-loop; other site 1233100001294 phosphorylation site [posttranslational modification] 1233100001295 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1233100001296 active site 1233100001297 phosphorylation site [posttranslational modification] 1233100001298 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1233100001299 tartrate dehydrogenase; Provisional; Region: PRK08194 1233100001300 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1233100001301 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1233100001302 Catalytic site [active] 1233100001303 Dienelactone hydrolase family; Region: DLH; pfam01738 1233100001304 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1233100001305 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1233100001306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100001307 active site 1233100001308 motif I; other site 1233100001309 motif II; other site 1233100001310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100001311 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1233100001312 putative active site [active] 1233100001313 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1233100001314 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1233100001315 hypothetical protein; Provisional; Region: PRK05463 1233100001316 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1233100001317 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1233100001318 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1233100001319 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1233100001320 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1233100001321 Bacterial transcriptional regulator; Region: IclR; pfam01614 1233100001322 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 1233100001323 active site 1233100001324 catalytic triad [active] 1233100001325 oxyanion hole [active] 1233100001326 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1233100001327 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1233100001328 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1233100001329 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1233100001330 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233100001331 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233100001332 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233100001333 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233100001334 active site 1233100001335 catalytic tetrad [active] 1233100001336 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1233100001337 HTH domain; Region: HTH_11; pfam08279 1233100001338 PRD domain; Region: PRD; pfam00874 1233100001339 PRD domain; Region: PRD; pfam00874 1233100001340 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1233100001341 active site 1233100001342 P-loop; other site 1233100001343 phosphorylation site [posttranslational modification] 1233100001344 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1233100001345 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1233100001346 acyl-activating enzyme (AAE) consensus motif; other site 1233100001347 putative AMP binding site [chemical binding]; other site 1233100001348 putative active site [active] 1233100001349 putative CoA binding site [chemical binding]; other site 1233100001350 short chain dehydrogenase; Provisional; Region: PRK06701 1233100001351 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1233100001352 NAD binding site [chemical binding]; other site 1233100001353 metal binding site [ion binding]; metal-binding site 1233100001354 active site 1233100001355 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1233100001356 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1233100001357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1233100001358 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1233100001359 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1233100001360 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1233100001361 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1233100001362 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1233100001363 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1233100001364 putative DNA binding site [nucleotide binding]; other site 1233100001365 putative Zn2+ binding site [ion binding]; other site 1233100001366 AsnC family; Region: AsnC_trans_reg; pfam01037 1233100001367 DNA topoisomerase III; Provisional; Region: PRK07726 1233100001368 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1233100001369 active site 1233100001370 putative interdomain interaction site [polypeptide binding]; other site 1233100001371 putative metal-binding site [ion binding]; other site 1233100001372 putative nucleotide binding site [chemical binding]; other site 1233100001373 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1233100001374 domain I; other site 1233100001375 DNA binding groove [nucleotide binding] 1233100001376 phosphate binding site [ion binding]; other site 1233100001377 domain II; other site 1233100001378 domain III; other site 1233100001379 nucleotide binding site [chemical binding]; other site 1233100001380 catalytic site [active] 1233100001381 domain IV; other site 1233100001382 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1233100001383 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1233100001384 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1233100001385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233100001386 metal binding site [ion binding]; metal-binding site 1233100001387 active site 1233100001388 I-site; other site 1233100001389 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1233100001390 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1233100001391 NodB motif; other site 1233100001392 putative active site [active] 1233100001393 putative catalytic site [active] 1233100001394 putative Zn binding site [ion binding]; other site 1233100001395 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1233100001396 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1233100001397 DXD motif; other site 1233100001398 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1233100001399 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1233100001400 Amino acid permease; Region: AA_permease_2; pfam13520 1233100001401 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1233100001402 nudix motif; other site 1233100001403 pyruvate oxidase; Provisional; Region: PRK08611 1233100001404 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1233100001405 PYR/PP interface [polypeptide binding]; other site 1233100001406 tetramer interface [polypeptide binding]; other site 1233100001407 dimer interface [polypeptide binding]; other site 1233100001408 TPP binding site [chemical binding]; other site 1233100001409 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1233100001410 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1233100001411 TPP-binding site [chemical binding]; other site 1233100001412 manganese transport protein MntH; Reviewed; Region: PRK00701 1233100001413 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1233100001414 Predicted membrane protein [Function unknown]; Region: COG2261 1233100001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1233100001416 EcsC protein family; Region: EcsC; pfam12787 1233100001417 General stress protein [General function prediction only]; Region: GsiB; COG3729 1233100001418 General stress protein [General function prediction only]; Region: GsiB; COG3729 1233100001419 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1233100001420 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1233100001421 dimanganese center [ion binding]; other site 1233100001422 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1233100001423 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1233100001424 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1233100001425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100001426 putative active site [active] 1233100001427 heme pocket [chemical binding]; other site 1233100001428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100001429 ATP binding site [chemical binding]; other site 1233100001430 Mg2+ binding site [ion binding]; other site 1233100001431 G-X-G motif; other site 1233100001432 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1233100001433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100001434 active site 1233100001435 phosphorylation site [posttranslational modification] 1233100001436 intermolecular recognition site; other site 1233100001437 dimerization interface [polypeptide binding]; other site 1233100001438 HTH domain; Region: HTH_11; cl17392 1233100001439 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1233100001440 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1233100001441 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1233100001442 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1233100001443 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1233100001444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100001445 Walker A/P-loop; other site 1233100001446 ATP binding site [chemical binding]; other site 1233100001447 Q-loop/lid; other site 1233100001448 ABC transporter signature motif; other site 1233100001449 Walker B; other site 1233100001450 D-loop; other site 1233100001451 H-loop/switch region; other site 1233100001452 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1233100001453 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1233100001454 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233100001455 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1233100001456 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1233100001457 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1233100001458 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1233100001459 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1233100001460 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233100001461 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233100001462 catalytic residues [active] 1233100001463 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1233100001464 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1233100001465 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1233100001466 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1233100001467 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1233100001468 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233100001469 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233100001470 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1233100001471 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1233100001472 ATP binding site [chemical binding]; other site 1233100001473 Mg++ binding site [ion binding]; other site 1233100001474 motif III; other site 1233100001475 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100001476 nucleotide binding region [chemical binding]; other site 1233100001477 ATP-binding site [chemical binding]; other site 1233100001478 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1233100001479 Predicted membrane protein [Function unknown]; Region: COG3428 1233100001480 Bacterial PH domain; Region: DUF304; pfam03703 1233100001481 Bacterial PH domain; Region: DUF304; pfam03703 1233100001482 Bacterial PH domain; Region: DUF304; pfam03703 1233100001483 Rhomboid family; Region: Rhomboid; pfam01694 1233100001484 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1233100001485 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1233100001486 alanine racemase; Region: alr; TIGR00492 1233100001487 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1233100001488 active site 1233100001489 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1233100001490 dimer interface [polypeptide binding]; other site 1233100001491 substrate binding site [chemical binding]; other site 1233100001492 catalytic residues [active] 1233100001493 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1233100001494 ribbon-helix-helix domain containing protein; Region: PHA00617 1233100001495 PemK-like protein; Region: PemK; pfam02452 1233100001496 Rsbr N terminal; Region: Rsbr_N; pfam08678 1233100001497 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1233100001498 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1233100001499 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1233100001500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100001501 ATP binding site [chemical binding]; other site 1233100001502 Mg2+ binding site [ion binding]; other site 1233100001503 G-X-G motif; other site 1233100001504 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1233100001505 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1233100001506 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1233100001507 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1233100001508 anti sigma factor interaction site; other site 1233100001509 regulatory phosphorylation site [posttranslational modification]; other site 1233100001510 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1233100001511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100001512 ATP binding site [chemical binding]; other site 1233100001513 Mg2+ binding site [ion binding]; other site 1233100001514 G-X-G motif; other site 1233100001515 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1233100001516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100001517 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233100001518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100001519 DNA binding residues [nucleotide binding] 1233100001520 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1233100001521 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1233100001522 hydrophobic ligand binding site; other site 1233100001523 hypothetical protein; Provisional; Region: PRK02268 1233100001524 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100001525 MarR family; Region: MarR; pfam01047 1233100001526 MarR family; Region: MarR_2; cl17246 1233100001527 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1233100001528 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1233100001529 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1233100001530 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1233100001531 RNA binding site [nucleotide binding]; other site 1233100001532 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1233100001533 hypothetical protein; Provisional; Region: PRK04351 1233100001534 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1233100001535 active site 1233100001536 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1233100001537 active site 1233100001538 ATP binding site [chemical binding]; other site 1233100001539 substrate binding site [chemical binding]; other site 1233100001540 activation loop (A-loop); other site 1233100001541 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1233100001542 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1233100001543 active site 1233100001544 zinc binding site [ion binding]; other site 1233100001545 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1233100001546 active site 1233100001547 ATP binding site [chemical binding]; other site 1233100001548 substrate binding site [chemical binding]; other site 1233100001549 activation loop (A-loop); other site 1233100001550 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 1233100001551 active site 1233100001552 zinc binding site [ion binding]; other site 1233100001553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233100001554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100001555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100001556 Walker A/P-loop; other site 1233100001557 ATP binding site [chemical binding]; other site 1233100001558 Q-loop/lid; other site 1233100001559 ABC transporter signature motif; other site 1233100001560 Walker B; other site 1233100001561 D-loop; other site 1233100001562 H-loop/switch region; other site 1233100001563 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1233100001564 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1233100001565 putative di-iron ligands [ion binding]; other site 1233100001566 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1233100001567 DNA-binding site [nucleotide binding]; DNA binding site 1233100001568 RNA-binding motif; other site 1233100001569 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1233100001570 Cupin domain; Region: Cupin_2; pfam07883 1233100001571 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233100001572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100001573 EamA-like transporter family; Region: EamA; pfam00892 1233100001574 EamA-like transporter family; Region: EamA; pfam00892 1233100001575 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233100001576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100001577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1233100001578 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1233100001579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100001580 DNA-binding site [nucleotide binding]; DNA binding site 1233100001581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100001582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100001583 homodimer interface [polypeptide binding]; other site 1233100001584 catalytic residue [active] 1233100001585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1233100001586 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1233100001587 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1233100001588 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1233100001589 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1233100001590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100001591 DNA-binding site [nucleotide binding]; DNA binding site 1233100001592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100001593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100001594 homodimer interface [polypeptide binding]; other site 1233100001595 catalytic residue [active] 1233100001596 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1233100001597 putative active site [active] 1233100001598 putative catalytic site [active] 1233100001599 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1233100001600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1233100001601 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233100001602 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233100001603 Predicted transcriptional regulators [Transcription]; Region: COG1733 1233100001604 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1233100001605 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1233100001606 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1233100001607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100001609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100001610 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100001611 putative DNA binding site [nucleotide binding]; other site 1233100001612 dimerization interface [polypeptide binding]; other site 1233100001613 arsenical pump membrane protein; Provisional; Region: PRK15445 1233100001614 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1233100001615 transmembrane helices; other site 1233100001616 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1233100001617 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1233100001618 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1233100001619 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1233100001620 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1233100001621 NodB motif; other site 1233100001622 active site 1233100001623 catalytic site [active] 1233100001624 Zn binding site [ion binding]; other site 1233100001625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100001626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100001627 dimerization interface [polypeptide binding]; other site 1233100001628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100001629 dimer interface [polypeptide binding]; other site 1233100001630 phosphorylation site [posttranslational modification] 1233100001631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100001632 ATP binding site [chemical binding]; other site 1233100001633 Mg2+ binding site [ion binding]; other site 1233100001634 G-X-G motif; other site 1233100001635 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1233100001636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100001637 DNA-binding site [nucleotide binding]; DNA binding site 1233100001638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100001639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100001640 homodimer interface [polypeptide binding]; other site 1233100001641 catalytic residue [active] 1233100001642 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1233100001643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100001644 putative DNA binding site [nucleotide binding]; other site 1233100001645 putative Zn2+ binding site [ion binding]; other site 1233100001646 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1233100001647 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1233100001648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1233100001649 Histidine kinase; Region: HisKA_3; pfam07730 1233100001650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100001651 ATP binding site [chemical binding]; other site 1233100001652 Mg2+ binding site [ion binding]; other site 1233100001653 G-X-G motif; other site 1233100001654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233100001655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100001656 active site 1233100001657 phosphorylation site [posttranslational modification] 1233100001658 intermolecular recognition site; other site 1233100001659 dimerization interface [polypeptide binding]; other site 1233100001660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233100001661 DNA binding residues [nucleotide binding] 1233100001662 dimerization interface [polypeptide binding]; other site 1233100001663 MMPL family; Region: MMPL; pfam03176 1233100001664 MMPL family; Region: MMPL; pfam03176 1233100001665 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100001666 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1233100001667 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1233100001668 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1233100001669 DNA binding residues [nucleotide binding] 1233100001670 drug binding residues [chemical binding]; other site 1233100001671 dimer interface [polypeptide binding]; other site 1233100001672 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1233100001673 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1233100001674 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1233100001675 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1233100001676 dimer interface [polypeptide binding]; other site 1233100001677 FMN binding site [chemical binding]; other site 1233100001678 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1233100001679 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100001680 Zn binding site [ion binding]; other site 1233100001681 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1233100001682 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100001683 Zn binding site [ion binding]; other site 1233100001684 Predicted membrane protein [Function unknown]; Region: COG2259 1233100001685 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233100001686 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233100001687 Predicted membrane protein [Function unknown]; Region: COG2323 1233100001688 Predicted membrane protein [Function unknown]; Region: COG2323 1233100001689 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1233100001690 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1233100001691 putative dimer interface [polypeptide binding]; other site 1233100001692 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233100001693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100001694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100001695 DoxX-like family; Region: DoxX_2; pfam13564 1233100001696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1233100001697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100001698 Coenzyme A binding pocket [chemical binding]; other site 1233100001699 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1233100001700 nucleotide binding site/active site [active] 1233100001701 HIT family signature motif; other site 1233100001702 catalytic residue [active] 1233100001703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100001704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100001705 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1233100001706 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100001707 ABC transporter; Region: ABC_tran_2; pfam12848 1233100001708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100001709 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1233100001710 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100001711 MarR family; Region: MarR; pfam01047 1233100001712 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1233100001713 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1233100001714 dimer interface [polypeptide binding]; other site 1233100001715 FMN binding site [chemical binding]; other site 1233100001716 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100001717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100001718 putative DNA binding site [nucleotide binding]; other site 1233100001719 putative Zn2+ binding site [ion binding]; other site 1233100001720 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1233100001721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001722 putative substrate translocation pore; other site 1233100001723 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1233100001724 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1233100001725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100001726 DNA-binding site [nucleotide binding]; DNA binding site 1233100001727 FCD domain; Region: FCD; pfam07729 1233100001728 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1233100001729 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100001730 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100001731 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1233100001732 active site 1233100001733 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1233100001734 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1233100001735 homodimer interface [polypeptide binding]; other site 1233100001736 active site 1233100001737 TDP-binding site; other site 1233100001738 acceptor substrate-binding pocket; other site 1233100001739 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1233100001740 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1233100001741 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1233100001742 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1233100001743 dimer interface [polypeptide binding]; other site 1233100001744 active site 1233100001745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100001746 Coenzyme A binding pocket [chemical binding]; other site 1233100001747 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1233100001748 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233100001749 Zn2+ binding site [ion binding]; other site 1233100001750 Mg2+ binding site [ion binding]; other site 1233100001751 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1233100001752 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1233100001753 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1233100001754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001755 putative substrate translocation pore; other site 1233100001756 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1233100001757 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1233100001758 active site 1233100001759 methionine cluster; other site 1233100001760 phosphorylation site [posttranslational modification] 1233100001761 metal binding site [ion binding]; metal-binding site 1233100001762 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1233100001763 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1233100001764 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1233100001765 beta-galactosidase; Region: BGL; TIGR03356 1233100001766 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233100001767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100001768 DNA-binding site [nucleotide binding]; DNA binding site 1233100001769 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1233100001770 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1233100001771 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233100001772 nucleotide binding site [chemical binding]; other site 1233100001773 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1233100001774 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1233100001775 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1233100001776 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1233100001777 dimanganese center [ion binding]; other site 1233100001778 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1233100001779 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1233100001780 ATP binding site [chemical binding]; other site 1233100001781 dimerization interface [polypeptide binding]; other site 1233100001782 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1233100001783 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1233100001784 Glycoprotease family; Region: Peptidase_M22; pfam00814 1233100001785 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1233100001786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100001787 Coenzyme A binding pocket [chemical binding]; other site 1233100001788 UGMP family protein; Validated; Region: PRK09604 1233100001789 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1233100001790 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1233100001791 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100001792 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100001793 ABC transporter; Region: ABC_tran_2; pfam12848 1233100001794 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100001795 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1233100001796 trimer interface [polypeptide binding]; other site 1233100001797 dimer interface [polypeptide binding]; other site 1233100001798 putative active site [active] 1233100001799 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1233100001800 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1233100001801 CoA binding domain; Region: CoA_binding; pfam02629 1233100001802 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1233100001803 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 1233100001804 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1233100001805 CAAX protease self-immunity; Region: Abi; pfam02517 1233100001806 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1233100001807 oligomerisation interface [polypeptide binding]; other site 1233100001808 mobile loop; other site 1233100001809 roof hairpin; other site 1233100001810 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1233100001811 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1233100001812 ring oligomerisation interface [polypeptide binding]; other site 1233100001813 ATP/Mg binding site [chemical binding]; other site 1233100001814 stacking interactions; other site 1233100001815 hinge regions; other site 1233100001816 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1233100001817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233100001818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100001819 non-specific DNA binding site [nucleotide binding]; other site 1233100001820 salt bridge; other site 1233100001821 sequence-specific DNA binding site [nucleotide binding]; other site 1233100001822 Helix-turn-helix domain; Region: HTH_17; cl17695 1233100001823 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1233100001824 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1233100001825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100001826 non-specific DNA binding site [nucleotide binding]; other site 1233100001827 salt bridge; other site 1233100001828 sequence-specific DNA binding site [nucleotide binding]; other site 1233100001829 Hypothetical protein Yqai; Region: Yqai; pfam09466 1233100001830 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 1233100001831 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 1233100001832 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1233100001833 hypothetical protein; Provisional; Region: PRK06921 1233100001834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100001835 Walker A motif; other site 1233100001836 ATP binding site [chemical binding]; other site 1233100001837 Walker B motif; other site 1233100001838 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1233100001839 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1233100001840 YopX protein; Region: YopX; pfam09643 1233100001841 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1233100001842 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1233100001843 Phage terminase large subunit; Region: Terminase_3; cl12054 1233100001844 Terminase-like family; Region: Terminase_6; pfam03237 1233100001845 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 1233100001846 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1233100001847 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 1233100001848 Minor capsid protein; Region: Minor_capsid_1; pfam10665 1233100001849 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 1233100001850 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1233100001851 Interdomain contacts; other site 1233100001852 Cytokine receptor motif; other site 1233100001853 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 1233100001854 Phage-related minor tail protein [Function unknown]; Region: COG5280 1233100001855 membrane protein P6; Region: PHA01399 1233100001856 Phage-related protein [Function unknown]; Region: COG4722 1233100001857 Phage tail protein; Region: Sipho_tail; pfam05709 1233100001858 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1233100001859 Haemolysin XhlA; Region: XhlA; pfam10779 1233100001860 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1233100001861 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1233100001862 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1233100001863 amidase catalytic site [active] 1233100001864 Zn binding residues [ion binding]; other site 1233100001865 substrate binding site [chemical binding]; other site 1233100001866 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100001867 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1233100001868 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233100001869 Helix-turn-helix domain; Region: HTH_17; pfam12728 1233100001870 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 1233100001871 NB-ARC domain; Region: NB-ARC; pfam00931 1233100001872 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233100001873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100001874 TPR motif; other site 1233100001875 TPR repeat; Region: TPR_11; pfam13414 1233100001876 binding surface 1233100001877 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1233100001878 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1233100001879 inhibitor binding site; inhibition site 1233100001880 catalytic Zn binding site [ion binding]; other site 1233100001881 structural Zn binding site [ion binding]; other site 1233100001882 NADP binding site [chemical binding]; other site 1233100001883 tetramer interface [polypeptide binding]; other site 1233100001884 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1233100001885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001886 putative substrate translocation pore; other site 1233100001887 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1233100001888 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1233100001889 putative substrate binding site [chemical binding]; other site 1233100001890 putative ATP binding site [chemical binding]; other site 1233100001891 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1233100001892 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 1233100001893 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1233100001894 Repair protein; Region: Repair_PSII; pfam04536 1233100001895 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1233100001896 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1233100001897 Double zinc ribbon; Region: DZR; pfam12773 1233100001898 Ion channel; Region: Ion_trans_2; pfam07885 1233100001899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001900 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1233100001901 putative substrate translocation pore; other site 1233100001902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100001903 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1233100001904 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1233100001905 putative NAD(P) binding site [chemical binding]; other site 1233100001906 catalytic Zn binding site [ion binding]; other site 1233100001907 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1233100001908 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1233100001909 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100001910 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1233100001911 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1233100001912 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1233100001913 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1233100001914 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1233100001915 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1233100001916 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1233100001917 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1233100001918 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1233100001919 MoxR-like ATPases [General function prediction only]; Region: COG0714 1233100001920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100001921 Walker A motif; other site 1233100001922 ATP binding site [chemical binding]; other site 1233100001923 Walker B motif; other site 1233100001924 arginine finger; other site 1233100001925 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1233100001926 Protein of unknown function DUF58; Region: DUF58; pfam01882 1233100001927 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1233100001928 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1233100001929 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1233100001930 GMP synthase; Reviewed; Region: guaA; PRK00074 1233100001931 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1233100001932 AMP/PPi binding site [chemical binding]; other site 1233100001933 candidate oxyanion hole; other site 1233100001934 catalytic triad [active] 1233100001935 potential glutamine specificity residues [chemical binding]; other site 1233100001936 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1233100001937 ATP Binding subdomain [chemical binding]; other site 1233100001938 Ligand Binding sites [chemical binding]; other site 1233100001939 Dimerization subdomain; other site 1233100001940 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1233100001941 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100001942 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100001943 DNA binding residues [nucleotide binding] 1233100001944 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1233100001945 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1233100001946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1233100001947 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233100001948 NETI protein; Region: NETI; pfam14044 1233100001949 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1233100001950 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1233100001951 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1233100001952 NAD binding site [chemical binding]; other site 1233100001953 ATP-grasp domain; Region: ATP-grasp; pfam02222 1233100001954 adenylosuccinate lyase; Provisional; Region: PRK07492 1233100001955 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1233100001956 tetramer interface [polypeptide binding]; other site 1233100001957 active site 1233100001958 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1233100001959 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1233100001960 ATP binding site [chemical binding]; other site 1233100001961 active site 1233100001962 substrate binding site [chemical binding]; other site 1233100001963 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1233100001964 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1233100001965 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1233100001966 putative active site [active] 1233100001967 catalytic triad [active] 1233100001968 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1233100001969 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1233100001970 dimerization interface [polypeptide binding]; other site 1233100001971 ATP binding site [chemical binding]; other site 1233100001972 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1233100001973 dimerization interface [polypeptide binding]; other site 1233100001974 ATP binding site [chemical binding]; other site 1233100001975 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1233100001976 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1233100001977 active site 1233100001978 tetramer interface [polypeptide binding]; other site 1233100001979 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100001980 active site 1233100001981 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1233100001982 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1233100001983 dimerization interface [polypeptide binding]; other site 1233100001984 putative ATP binding site [chemical binding]; other site 1233100001985 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1233100001986 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1233100001987 active site 1233100001988 substrate binding site [chemical binding]; other site 1233100001989 cosubstrate binding site; other site 1233100001990 catalytic site [active] 1233100001991 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1233100001992 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1233100001993 purine monophosphate binding site [chemical binding]; other site 1233100001994 dimer interface [polypeptide binding]; other site 1233100001995 putative catalytic residues [active] 1233100001996 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1233100001997 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1233100001998 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1233100001999 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1233100002000 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1233100002001 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1233100002002 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1233100002003 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1233100002004 putative DNA binding site [nucleotide binding]; other site 1233100002005 AsnC family; Region: AsnC_trans_reg; pfam01037 1233100002006 putative transporter; Provisional; Region: PRK11021 1233100002007 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1233100002008 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1233100002009 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1233100002010 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1233100002011 active site 1233100002012 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1233100002013 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1233100002014 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1233100002015 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1233100002016 active site 1233100002017 FMN binding site [chemical binding]; other site 1233100002018 substrate binding site [chemical binding]; other site 1233100002019 3Fe-4S cluster binding site [ion binding]; other site 1233100002020 PcrB family; Region: PcrB; pfam01884 1233100002021 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1233100002022 substrate binding site [chemical binding]; other site 1233100002023 putative active site [active] 1233100002024 dimer interface [polypeptide binding]; other site 1233100002025 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1233100002026 Part of AAA domain; Region: AAA_19; pfam13245 1233100002027 Family description; Region: UvrD_C_2; pfam13538 1233100002028 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1233100002029 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1233100002030 nucleotide binding pocket [chemical binding]; other site 1233100002031 K-X-D-G motif; other site 1233100002032 catalytic site [active] 1233100002033 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1233100002034 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1233100002035 Helix-hairpin-helix motif; Region: HHH; pfam00633 1233100002036 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1233100002037 Dimer interface [polypeptide binding]; other site 1233100002038 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1233100002039 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1233100002040 putative dimer interface [polypeptide binding]; other site 1233100002041 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1233100002042 putative dimer interface [polypeptide binding]; other site 1233100002043 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1233100002044 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1233100002045 active site 1233100002046 ATP binding site [chemical binding]; other site 1233100002047 substrate binding site [chemical binding]; other site 1233100002048 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1233100002049 MgtC family; Region: MgtC; pfam02308 1233100002050 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1233100002051 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1233100002052 Na binding site [ion binding]; other site 1233100002053 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1233100002054 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1233100002055 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1233100002056 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1233100002057 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1233100002058 GatB domain; Region: GatB_Yqey; pfam02637 1233100002059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100002060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100002061 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1233100002062 Protein export membrane protein; Region: SecD_SecF; cl14618 1233100002063 Protein export membrane protein; Region: SecD_SecF; cl14618 1233100002064 putative lipid kinase; Reviewed; Region: PRK13337 1233100002065 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1233100002066 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1233100002067 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1233100002068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100002069 S-adenosylmethionine binding site [chemical binding]; other site 1233100002070 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1233100002071 Predicted ATPase [General function prediction only]; Region: COG5293 1233100002072 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 1233100002073 Protein of unknown function, DUF600; Region: DUF600; cl04640 1233100002074 Protein of unknown function, DUF600; Region: DUF600; cl04640 1233100002075 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1233100002076 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1233100002077 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1233100002078 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1233100002079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100002080 binding surface 1233100002081 TPR motif; other site 1233100002082 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233100002083 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233100002084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100002085 TPR motif; other site 1233100002086 binding surface 1233100002087 hypothetical protein; Provisional; Region: PRK12378 1233100002088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100002089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100002090 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1233100002091 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1233100002092 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1233100002093 NADP binding site [chemical binding]; other site 1233100002094 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1233100002095 CotJB protein; Region: CotJB; pfam12652 1233100002096 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1233100002097 dimanganese center [ion binding]; other site 1233100002098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100002099 Coenzyme A binding pocket [chemical binding]; other site 1233100002100 YesK-like protein; Region: YesK; pfam14150 1233100002101 Predicted integral membrane protein [Function unknown]; Region: COG5578 1233100002102 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1233100002103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100002104 dimerization interface [polypeptide binding]; other site 1233100002105 Histidine kinase; Region: His_kinase; pfam06580 1233100002106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100002107 ATP binding site [chemical binding]; other site 1233100002108 Mg2+ binding site [ion binding]; other site 1233100002109 G-X-G motif; other site 1233100002110 Response regulator receiver domain; Region: Response_reg; pfam00072 1233100002111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100002112 active site 1233100002113 phosphorylation site [posttranslational modification] 1233100002114 intermolecular recognition site; other site 1233100002115 dimerization interface [polypeptide binding]; other site 1233100002116 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233100002117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100002118 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233100002119 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233100002120 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233100002121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100002122 dimer interface [polypeptide binding]; other site 1233100002123 conserved gate region; other site 1233100002124 putative PBP binding loops; other site 1233100002125 ABC-ATPase subunit interface; other site 1233100002126 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233100002127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100002128 dimer interface [polypeptide binding]; other site 1233100002129 conserved gate region; other site 1233100002130 putative PBP binding loops; other site 1233100002131 ABC-ATPase subunit interface; other site 1233100002132 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1233100002133 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233100002134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100002135 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1233100002136 active site 1233100002137 catalytic triad [active] 1233100002138 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1233100002139 Predicted integral membrane protein [Function unknown]; Region: COG5578 1233100002140 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1233100002141 metal binding site [ion binding]; metal-binding site 1233100002142 active site 1233100002143 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1233100002144 metal binding site [ion binding]; metal-binding site 1233100002145 active site 1233100002146 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1233100002147 active site 1233100002148 catalytic triad [active] 1233100002149 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1233100002150 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1233100002151 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1233100002152 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1233100002153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233100002154 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233100002155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100002156 dimer interface [polypeptide binding]; other site 1233100002157 putative PBP binding loops; other site 1233100002158 ABC-ATPase subunit interface; other site 1233100002159 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233100002160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100002161 dimer interface [polypeptide binding]; other site 1233100002162 conserved gate region; other site 1233100002163 putative PBP binding loops; other site 1233100002164 ABC-ATPase subunit interface; other site 1233100002165 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1233100002166 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1233100002167 NAD(P) binding site [chemical binding]; other site 1233100002168 LDH/MDH dimer interface [polypeptide binding]; other site 1233100002169 substrate binding site [chemical binding]; other site 1233100002170 Predicted membrane protein [Function unknown]; Region: COG2323 1233100002171 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1233100002172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100002173 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1233100002174 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1233100002175 Uncharacterized small protein [Function unknown]; Region: COG5583 1233100002176 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1233100002177 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1233100002178 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1233100002179 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1233100002180 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1233100002181 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1233100002182 Cytochrome P450; Region: p450; pfam00067 1233100002183 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1233100002184 Flavodoxin; Region: Flavodoxin_1; pfam00258 1233100002185 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1233100002186 FAD binding pocket [chemical binding]; other site 1233100002187 FAD binding motif [chemical binding]; other site 1233100002188 catalytic residues [active] 1233100002189 NAD binding pocket [chemical binding]; other site 1233100002190 phosphate binding motif [ion binding]; other site 1233100002191 beta-alpha-beta structure motif; other site 1233100002192 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1233100002193 Sulfatase; Region: Sulfatase; pfam00884 1233100002194 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1233100002195 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1233100002196 substrate binding site; other site 1233100002197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233100002198 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1233100002199 NAD(P) binding site [chemical binding]; other site 1233100002200 active site 1233100002201 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1233100002202 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1233100002203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100002204 active site 1233100002205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1233100002206 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1233100002207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100002208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100002209 putative substrate translocation pore; other site 1233100002210 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1233100002211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100002212 active site 1233100002213 motif I; other site 1233100002214 motif II; other site 1233100002215 amino acid transporter; Region: 2A0306; TIGR00909 1233100002216 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1233100002217 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1233100002218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233100002219 NAD(P) binding site [chemical binding]; other site 1233100002220 catalytic residues [active] 1233100002221 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1233100002222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100002223 Walker A/P-loop; other site 1233100002224 ATP binding site [chemical binding]; other site 1233100002225 Q-loop/lid; other site 1233100002226 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100002227 ABC transporter signature motif; other site 1233100002228 Walker B; other site 1233100002229 D-loop; other site 1233100002230 ABC transporter; Region: ABC_tran_2; pfam12848 1233100002231 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100002232 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1233100002233 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1233100002234 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1233100002235 DNA binding residues [nucleotide binding] 1233100002236 putative dimer interface [polypeptide binding]; other site 1233100002237 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1233100002238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100002239 putative substrate translocation pore; other site 1233100002240 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1233100002241 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100002242 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100002243 ABC transporter; Region: ABC_tran_2; pfam12848 1233100002244 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100002245 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1233100002246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1233100002247 ATP binding site [chemical binding]; other site 1233100002248 putative Mg++ binding site [ion binding]; other site 1233100002249 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1233100002250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100002251 nucleotide binding region [chemical binding]; other site 1233100002252 ATP-binding site [chemical binding]; other site 1233100002253 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1233100002254 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1233100002255 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1233100002256 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1233100002257 NAD(P) binding site [chemical binding]; other site 1233100002258 substrate binding site [chemical binding]; other site 1233100002259 dimer interface [polypeptide binding]; other site 1233100002260 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1233100002261 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1233100002262 Walker A/P-loop; other site 1233100002263 ATP binding site [chemical binding]; other site 1233100002264 Q-loop/lid; other site 1233100002265 ABC transporter signature motif; other site 1233100002266 Walker B; other site 1233100002267 D-loop; other site 1233100002268 H-loop/switch region; other site 1233100002269 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233100002270 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100002271 ABC-ATPase subunit interface; other site 1233100002272 dimer interface [polypeptide binding]; other site 1233100002273 putative PBP binding regions; other site 1233100002274 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233100002275 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100002276 ABC-ATPase subunit interface; other site 1233100002277 dimer interface [polypeptide binding]; other site 1233100002278 putative PBP binding regions; other site 1233100002279 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1233100002280 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1233100002281 siderophore binding site; other site 1233100002282 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1233100002283 Heat induced stress protein YflT; Region: YflT; pfam11181 1233100002284 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1233100002285 Amb_all domain; Region: Amb_all; smart00656 1233100002286 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1233100002287 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1233100002288 transmembrane helices; other site 1233100002289 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1233100002290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100002291 ATP binding site [chemical binding]; other site 1233100002292 Mg2+ binding site [ion binding]; other site 1233100002293 G-X-G motif; other site 1233100002294 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1233100002295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100002296 active site 1233100002297 phosphorylation site [posttranslational modification] 1233100002298 intermolecular recognition site; other site 1233100002299 dimerization interface [polypeptide binding]; other site 1233100002300 Transcriptional regulator; Region: CitT; pfam12431 1233100002301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1233100002302 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1233100002303 Citrate transporter; Region: CitMHS; pfam03600 1233100002304 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233100002305 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1233100002306 active site 1233100002307 dimer interface [polypeptide binding]; other site 1233100002308 acylphosphatase; Provisional; Region: PRK14420 1233100002309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1233100002310 MOSC domain; Region: MOSC; pfam03473 1233100002311 3-alpha domain; Region: 3-alpha; pfam03475 1233100002312 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1233100002313 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1233100002314 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1233100002315 active site 1233100002316 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1233100002317 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233100002318 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233100002319 active site turn [active] 1233100002320 phosphorylation site [posttranslational modification] 1233100002321 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1233100002322 Sulfatase; Region: Sulfatase; pfam00884 1233100002323 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1233100002324 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1233100002325 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1233100002326 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1233100002327 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1233100002328 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1233100002329 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233100002330 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1233100002331 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233100002332 active site turn [active] 1233100002333 phosphorylation site [posttranslational modification] 1233100002334 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233100002335 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1233100002336 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1233100002337 Ca binding site [ion binding]; other site 1233100002338 active site 1233100002339 catalytic site [active] 1233100002340 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1233100002341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100002342 DNA-binding site [nucleotide binding]; DNA binding site 1233100002343 UTRA domain; Region: UTRA; pfam07702 1233100002344 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1233100002345 dimer interface [polypeptide binding]; other site 1233100002346 FMN binding site [chemical binding]; other site 1233100002347 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1233100002348 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1233100002349 active site 1233100002350 metal binding site [ion binding]; metal-binding site 1233100002351 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1233100002352 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1233100002353 active site 1233100002354 metal binding site [ion binding]; metal-binding site 1233100002355 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1233100002356 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1233100002357 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1233100002358 proposed catalytic triad [active] 1233100002359 conserved cys residue [active] 1233100002360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100002361 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100002362 putative substrate translocation pore; other site 1233100002363 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1233100002364 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1233100002365 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1233100002366 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 1233100002367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100002368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100002369 putative substrate translocation pore; other site 1233100002370 calcium/proton exchanger (cax); Region: cax; TIGR00378 1233100002371 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1233100002372 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1233100002373 YfkD-like protein; Region: YfkD; pfam14167 1233100002374 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1233100002375 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1233100002376 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1233100002377 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1233100002378 NodB motif; other site 1233100002379 active site 1233100002380 catalytic site [active] 1233100002381 Cd binding site [ion binding]; other site 1233100002382 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1233100002383 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1233100002384 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1233100002385 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1233100002386 oligomer interface [polypeptide binding]; other site 1233100002387 metal binding site [ion binding]; metal-binding site 1233100002388 metal binding site [ion binding]; metal-binding site 1233100002389 putative Cl binding site [ion binding]; other site 1233100002390 aspartate ring; other site 1233100002391 basic sphincter; other site 1233100002392 hydrophobic gate; other site 1233100002393 periplasmic entrance; other site 1233100002394 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1233100002395 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1233100002396 minor groove reading motif; other site 1233100002397 helix-hairpin-helix signature motif; other site 1233100002398 substrate binding pocket [chemical binding]; other site 1233100002399 active site 1233100002400 TRAM domain; Region: TRAM; pfam01938 1233100002401 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1233100002402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100002403 S-adenosylmethionine binding site [chemical binding]; other site 1233100002404 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1233100002405 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1233100002406 FMN binding site [chemical binding]; other site 1233100002407 active site 1233100002408 catalytic residues [active] 1233100002409 substrate binding site [chemical binding]; other site 1233100002410 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1233100002411 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1233100002412 tetramer interface [polypeptide binding]; other site 1233100002413 TPP-binding site [chemical binding]; other site 1233100002414 heterodimer interface [polypeptide binding]; other site 1233100002415 phosphorylation loop region [posttranslational modification] 1233100002416 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1233100002417 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1233100002418 alpha subunit interface [polypeptide binding]; other site 1233100002419 TPP binding site [chemical binding]; other site 1233100002420 heterodimer interface [polypeptide binding]; other site 1233100002421 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233100002422 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1233100002423 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1233100002424 E3 interaction surface; other site 1233100002425 lipoyl attachment site [posttranslational modification]; other site 1233100002426 e3 binding domain; Region: E3_binding; pfam02817 1233100002427 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1233100002428 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1233100002429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100002430 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1233100002431 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1233100002432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100002433 Walker A motif; other site 1233100002434 ATP binding site [chemical binding]; other site 1233100002435 Walker B motif; other site 1233100002436 arginine finger; other site 1233100002437 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1233100002438 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 1233100002439 hypothetical protein; Provisional; Region: PRK02237 1233100002440 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1233100002441 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1233100002442 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1233100002443 NAD binding site [chemical binding]; other site 1233100002444 sugar binding site [chemical binding]; other site 1233100002445 divalent metal binding site [ion binding]; other site 1233100002446 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233100002447 dimer interface [polypeptide binding]; other site 1233100002448 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1233100002449 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1233100002450 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1233100002451 putative active site [active] 1233100002452 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1233100002453 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1233100002454 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233100002455 active site turn [active] 1233100002456 phosphorylation site [posttranslational modification] 1233100002457 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233100002458 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100002459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100002460 Walker A/P-loop; other site 1233100002461 ATP binding site [chemical binding]; other site 1233100002462 Q-loop/lid; other site 1233100002463 ABC transporter signature motif; other site 1233100002464 Walker B; other site 1233100002465 D-loop; other site 1233100002466 H-loop/switch region; other site 1233100002467 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233100002468 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100002469 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1233100002470 Walker A/P-loop; other site 1233100002471 ATP binding site [chemical binding]; other site 1233100002472 Q-loop/lid; other site 1233100002473 ABC transporter signature motif; other site 1233100002474 Walker B; other site 1233100002475 D-loop; other site 1233100002476 H-loop/switch region; other site 1233100002477 Predicted membrane protein [Function unknown]; Region: COG2259 1233100002478 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1233100002479 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1233100002480 putative metal binding site [ion binding]; other site 1233100002481 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1233100002482 active site 1233100002483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1233100002484 Histidine kinase; Region: HisKA_3; pfam07730 1233100002485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100002486 ATP binding site [chemical binding]; other site 1233100002487 Mg2+ binding site [ion binding]; other site 1233100002488 G-X-G motif; other site 1233100002489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233100002490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100002491 active site 1233100002492 phosphorylation site [posttranslational modification] 1233100002493 intermolecular recognition site; other site 1233100002494 dimerization interface [polypeptide binding]; other site 1233100002495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233100002496 DNA binding residues [nucleotide binding] 1233100002497 dimerization interface [polypeptide binding]; other site 1233100002498 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1233100002499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100002500 Walker A/P-loop; other site 1233100002501 ATP binding site [chemical binding]; other site 1233100002502 Q-loop/lid; other site 1233100002503 ABC transporter signature motif; other site 1233100002504 Walker B; other site 1233100002505 D-loop; other site 1233100002506 H-loop/switch region; other site 1233100002507 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1233100002508 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1233100002509 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1233100002510 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1233100002511 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1233100002512 Predicted transcriptional regulators [Transcription]; Region: COG1695 1233100002513 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1233100002514 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1233100002515 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1233100002516 Lipase (class 2); Region: Lipase_2; pfam01674 1233100002517 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1233100002518 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1233100002519 NAD binding site [chemical binding]; other site 1233100002520 substrate binding site [chemical binding]; other site 1233100002521 putative active site [active] 1233100002522 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1233100002523 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1233100002524 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1233100002525 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1233100002526 Walker A/P-loop; other site 1233100002527 ATP binding site [chemical binding]; other site 1233100002528 Q-loop/lid; other site 1233100002529 ABC transporter signature motif; other site 1233100002530 Walker B; other site 1233100002531 D-loop; other site 1233100002532 H-loop/switch region; other site 1233100002533 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1233100002534 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1233100002535 H+ Antiporter protein; Region: 2A0121; TIGR00900 1233100002536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100002537 putative substrate translocation pore; other site 1233100002538 metal-dependent hydrolase; Provisional; Region: PRK13291 1233100002539 DinB superfamily; Region: DinB_2; pfam12867 1233100002540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100002541 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100002542 putative substrate translocation pore; other site 1233100002543 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100002544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100002545 putative Zn2+ binding site [ion binding]; other site 1233100002546 putative DNA binding site [nucleotide binding]; other site 1233100002547 Predicted integral membrane protein [Function unknown]; Region: COG0392 1233100002548 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1233100002549 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1233100002550 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1233100002551 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1233100002552 siderophore binding site; other site 1233100002553 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233100002554 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100002555 ABC-ATPase subunit interface; other site 1233100002556 dimer interface [polypeptide binding]; other site 1233100002557 putative PBP binding regions; other site 1233100002558 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1233100002559 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100002560 ABC-ATPase subunit interface; other site 1233100002561 dimer interface [polypeptide binding]; other site 1233100002562 putative PBP binding regions; other site 1233100002563 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1233100002564 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1233100002565 putative FMN binding site [chemical binding]; other site 1233100002566 YfhD-like protein; Region: YfhD; pfam14151 1233100002567 YfhE-like protein; Region: YfhE; pfam14152 1233100002568 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1233100002569 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1233100002570 putative NAD(P) binding site [chemical binding]; other site 1233100002571 putative active site [active] 1233100002572 recombination regulator RecX; Provisional; Region: recX; PRK14135 1233100002573 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1233100002574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100002575 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1233100002576 putative substrate translocation pore; other site 1233100002577 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1233100002578 WVELL protein; Region: WVELL; pfam14043 1233100002579 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233100002580 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233100002581 Predicted integral membrane protein [Function unknown]; Region: COG5658 1233100002582 SdpI/YhfL protein family; Region: SdpI; pfam13630 1233100002583 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100002584 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1233100002585 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1233100002586 catalytic site [active] 1233100002587 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1233100002588 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1233100002589 Ligand binding site; other site 1233100002590 Putative Catalytic site; other site 1233100002591 DXD motif; other site 1233100002592 Predicted membrane protein [Function unknown]; Region: COG4485 1233100002593 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1233100002594 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1233100002595 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1233100002596 minor groove reading motif; other site 1233100002597 helix-hairpin-helix signature motif; other site 1233100002598 substrate binding pocket [chemical binding]; other site 1233100002599 active site 1233100002600 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1233100002601 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1233100002602 DNA binding and oxoG recognition site [nucleotide binding] 1233100002603 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1233100002604 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1233100002605 putative NAD(P) binding site [chemical binding]; other site 1233100002606 active site 1233100002607 YgaB-like protein; Region: YgaB; pfam14182 1233100002608 hypothetical protein; Provisional; Region: PRK13662 1233100002609 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233100002610 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100002611 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1233100002612 Walker A/P-loop; other site 1233100002613 ATP binding site [chemical binding]; other site 1233100002614 Q-loop/lid; other site 1233100002615 ABC transporter signature motif; other site 1233100002616 Walker B; other site 1233100002617 D-loop; other site 1233100002618 H-loop/switch region; other site 1233100002619 Predicted membrane protein [Function unknown]; Region: COG4129 1233100002620 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1233100002621 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1233100002622 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233100002623 inhibitor-cofactor binding pocket; inhibition site 1233100002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100002625 catalytic residue [active] 1233100002626 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1233100002627 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1233100002628 catalytic triad [active] 1233100002629 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1233100002630 metal binding site 2 [ion binding]; metal-binding site 1233100002631 putative DNA binding helix; other site 1233100002632 metal binding site 1 [ion binding]; metal-binding site 1233100002633 dimer interface [polypeptide binding]; other site 1233100002634 structural Zn2+ binding site [ion binding]; other site 1233100002635 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1233100002636 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1233100002637 SpoOM protein; Region: Spo0M; pfam07070 1233100002638 Coat F domain; Region: Coat_F; pfam07875 1233100002639 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1233100002640 active site pocket [active] 1233100002641 oxyanion hole [active] 1233100002642 catalytic triad [active] 1233100002643 active site nucleophile [active] 1233100002644 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1233100002645 ThiC-associated domain; Region: ThiC-associated; pfam13667 1233100002646 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1233100002647 Berberine and berberine like; Region: BBE; pfam08031 1233100002648 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1233100002649 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1233100002650 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1233100002651 tetramer interface [polypeptide binding]; other site 1233100002652 heme binding pocket [chemical binding]; other site 1233100002653 NADPH binding site [chemical binding]; other site 1233100002654 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1233100002655 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1233100002656 Walker A/P-loop; other site 1233100002657 ATP binding site [chemical binding]; other site 1233100002658 Q-loop/lid; other site 1233100002659 ABC transporter signature motif; other site 1233100002660 Walker B; other site 1233100002661 D-loop; other site 1233100002662 H-loop/switch region; other site 1233100002663 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1233100002664 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233100002665 substrate binding pocket [chemical binding]; other site 1233100002666 membrane-bound complex binding site; other site 1233100002667 hinge residues; other site 1233100002668 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1233100002669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100002670 dimer interface [polypeptide binding]; other site 1233100002671 conserved gate region; other site 1233100002672 putative PBP binding loops; other site 1233100002673 ABC-ATPase subunit interface; other site 1233100002674 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1233100002675 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1233100002676 active site 1233100002677 dimer interface [polypeptide binding]; other site 1233100002678 non-prolyl cis peptide bond; other site 1233100002679 insertion regions; other site 1233100002680 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1233100002681 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233100002682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100002683 non-specific DNA binding site [nucleotide binding]; other site 1233100002684 salt bridge; other site 1233100002685 sequence-specific DNA binding site [nucleotide binding]; other site 1233100002686 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1233100002687 B3/4 domain; Region: B3_4; pfam03483 1233100002688 epoxyqueuosine reductase; Region: TIGR00276 1233100002689 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1233100002690 Putative amidase domain; Region: Amidase_6; pfam12671 1233100002691 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1233100002692 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1233100002693 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1233100002694 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1233100002695 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1233100002696 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1233100002697 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1233100002698 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1233100002699 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100002700 MarR family; Region: MarR; pfam01047 1233100002701 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1233100002702 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1233100002703 carboxyltransferase (CT) interaction site; other site 1233100002704 biotinylation site [posttranslational modification]; other site 1233100002705 HlyD family secretion protein; Region: HlyD_3; pfam13437 1233100002706 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1233100002707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100002708 putative substrate translocation pore; other site 1233100002709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100002710 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1233100002711 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1233100002712 Predicted transcriptional regulators [Transcription]; Region: COG1725 1233100002713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100002714 DNA-binding site [nucleotide binding]; DNA binding site 1233100002715 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1233100002716 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233100002717 Walker A/P-loop; other site 1233100002718 ATP binding site [chemical binding]; other site 1233100002719 Q-loop/lid; other site 1233100002720 ABC transporter signature motif; other site 1233100002721 Walker B; other site 1233100002722 D-loop; other site 1233100002723 H-loop/switch region; other site 1233100002724 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1233100002725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100002726 Walker A/P-loop; other site 1233100002727 ATP binding site [chemical binding]; other site 1233100002728 Q-loop/lid; other site 1233100002729 ABC transporter signature motif; other site 1233100002730 Walker B; other site 1233100002731 D-loop; other site 1233100002732 H-loop/switch region; other site 1233100002733 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1233100002734 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1233100002735 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1233100002736 DNA-binding site [nucleotide binding]; DNA binding site 1233100002737 RNA-binding motif; other site 1233100002738 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1233100002739 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1233100002740 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1233100002741 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1233100002742 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233100002743 metal binding site [ion binding]; metal-binding site 1233100002744 active site 1233100002745 I-site; other site 1233100002746 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1233100002747 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1233100002748 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1233100002749 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1233100002750 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1233100002751 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1233100002752 generic binding surface II; other site 1233100002753 generic binding surface I; other site 1233100002754 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1233100002755 generic binding surface II; other site 1233100002756 generic binding surface I; other site 1233100002757 Staphylococcal nuclease homologues; Region: SNc; smart00318 1233100002758 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1233100002759 Catalytic site; other site 1233100002760 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1233100002761 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1233100002762 putative active site [active] 1233100002763 putative metal binding site [ion binding]; other site 1233100002764 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1233100002765 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1233100002766 active site 1233100002767 catalytic site [active] 1233100002768 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1233100002769 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233100002770 RNA binding surface [nucleotide binding]; other site 1233100002771 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1233100002772 active site 1233100002773 FOG: CBS domain [General function prediction only]; Region: COG0517 1233100002774 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1233100002775 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1233100002776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100002777 motif II; other site 1233100002778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100002779 Coenzyme A binding pocket [chemical binding]; other site 1233100002780 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1233100002781 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1233100002782 putative active site [active] 1233100002783 catalytic triad [active] 1233100002784 putative dimer interface [polypeptide binding]; other site 1233100002785 aminotransferase; Validated; Region: PRK07678 1233100002786 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233100002787 inhibitor-cofactor binding pocket; inhibition site 1233100002788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100002789 catalytic residue [active] 1233100002790 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1233100002791 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1233100002792 amphipathic channel; other site 1233100002793 Asn-Pro-Ala signature motifs; other site 1233100002794 glycerol kinase; Provisional; Region: glpK; PRK00047 1233100002795 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1233100002796 N- and C-terminal domain interface [polypeptide binding]; other site 1233100002797 active site 1233100002798 MgATP binding site [chemical binding]; other site 1233100002799 catalytic site [active] 1233100002800 metal binding site [ion binding]; metal-binding site 1233100002801 glycerol binding site [chemical binding]; other site 1233100002802 homotetramer interface [polypeptide binding]; other site 1233100002803 homodimer interface [polypeptide binding]; other site 1233100002804 FBP binding site [chemical binding]; other site 1233100002805 protein IIAGlc interface [polypeptide binding]; other site 1233100002806 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1233100002807 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1233100002808 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1233100002809 active site 1233100002810 substrate binding site [chemical binding]; other site 1233100002811 metal binding site [ion binding]; metal-binding site 1233100002812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100002813 ATP binding site [chemical binding]; other site 1233100002814 Mg2+ binding site [ion binding]; other site 1233100002815 G-X-G motif; other site 1233100002816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233100002817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100002818 active site 1233100002819 phosphorylation site [posttranslational modification] 1233100002820 intermolecular recognition site; other site 1233100002821 dimerization interface [polypeptide binding]; other site 1233100002822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233100002823 DNA binding residues [nucleotide binding] 1233100002824 dimerization interface [polypeptide binding]; other site 1233100002825 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1233100002826 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100002827 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100002828 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100002829 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100002830 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100002831 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233100002832 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233100002833 Transcriptional regulator; Region: Rrf2; cl17282 1233100002834 Rrf2 family protein; Region: rrf2_super; TIGR00738 1233100002835 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1233100002836 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1233100002837 dimer interface [polypeptide binding]; other site 1233100002838 active site 1233100002839 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100002840 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100002841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100002842 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233100002843 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233100002844 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100002845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100002846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233100002847 dimerization interface [polypeptide binding]; other site 1233100002848 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1233100002849 dimer interface [polypeptide binding]; other site 1233100002850 Citrate synthase; Region: Citrate_synt; pfam00285 1233100002851 active site 1233100002852 citrylCoA binding site [chemical binding]; other site 1233100002853 oxalacetate/citrate binding site [chemical binding]; other site 1233100002854 coenzyme A binding site [chemical binding]; other site 1233100002855 catalytic triad [active] 1233100002856 short chain dehydrogenase; Provisional; Region: PRK06701 1233100002857 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1233100002858 NAD binding site [chemical binding]; other site 1233100002859 metal binding site [ion binding]; metal-binding site 1233100002860 active site 1233100002861 amino acid transporter; Region: 2A0306; TIGR00909 1233100002862 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1233100002863 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1233100002864 putative substrate binding site 2 [chemical binding]; other site 1233100002865 putative substrate binding site 1 [chemical binding]; other site 1233100002866 Na binding site 1 [ion binding]; other site 1233100002867 Na2 binding site [ion binding]; other site 1233100002868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100002869 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1233100002870 homodimer interface [polypeptide binding]; other site 1233100002871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100002872 catalytic residue [active] 1233100002873 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1233100002874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100002875 DNA-binding site [nucleotide binding]; DNA binding site 1233100002876 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1233100002877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233100002878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1233100002879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100002880 Coenzyme A binding pocket [chemical binding]; other site 1233100002881 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1233100002882 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1233100002883 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1233100002884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100002885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100002886 DNA binding residues [nucleotide binding] 1233100002887 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233100002888 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233100002889 active site 1233100002890 catalytic tetrad [active] 1233100002891 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1233100002892 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1233100002893 putative acyl-acceptor binding pocket; other site 1233100002894 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1233100002895 Domain of unknown function DUF21; Region: DUF21; pfam01595 1233100002896 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1233100002897 Transporter associated domain; Region: CorC_HlyC; smart01091 1233100002898 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1233100002899 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1233100002900 DNA binding residues [nucleotide binding] 1233100002901 putative dimer interface [polypeptide binding]; other site 1233100002902 aspartate aminotransferase; Provisional; Region: PRK06836 1233100002903 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100002904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100002905 homodimer interface [polypeptide binding]; other site 1233100002906 catalytic residue [active] 1233100002907 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1233100002908 Domain of unknown function DUF21; Region: DUF21; pfam01595 1233100002909 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1233100002910 Transporter associated domain; Region: CorC_HlyC; smart01091 1233100002911 camphor resistance protein CrcB; Provisional; Region: PRK14213 1233100002912 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1233100002913 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1233100002914 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1233100002915 active site 1233100002916 catalytic site [active] 1233100002917 metal binding site [ion binding]; metal-binding site 1233100002918 dimer interface [polypeptide binding]; other site 1233100002919 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1233100002920 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1233100002921 NAD-dependent deacetylase; Provisional; Region: PRK00481 1233100002922 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1233100002923 NAD+ binding site [chemical binding]; other site 1233100002924 substrate binding site [chemical binding]; other site 1233100002925 Zn binding site [ion binding]; other site 1233100002926 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1233100002927 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1233100002928 homodimer interface [polypeptide binding]; other site 1233100002929 substrate-cofactor binding pocket; other site 1233100002930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100002931 catalytic residue [active] 1233100002932 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1233100002933 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1233100002934 Ligand Binding Site [chemical binding]; other site 1233100002935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100002936 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1233100002937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100002938 Walker A/P-loop; other site 1233100002939 ATP binding site [chemical binding]; other site 1233100002940 Q-loop/lid; other site 1233100002941 ABC transporter signature motif; other site 1233100002942 Walker B; other site 1233100002943 D-loop; other site 1233100002944 H-loop/switch region; other site 1233100002945 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233100002946 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100002947 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1233100002948 Walker A/P-loop; other site 1233100002949 ATP binding site [chemical binding]; other site 1233100002950 Q-loop/lid; other site 1233100002951 ABC transporter signature motif; other site 1233100002952 Walker B; other site 1233100002953 D-loop; other site 1233100002954 H-loop/switch region; other site 1233100002955 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1233100002956 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1233100002957 NAD binding site [chemical binding]; other site 1233100002958 substrate binding site [chemical binding]; other site 1233100002959 putative active site [active] 1233100002960 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1233100002961 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1233100002962 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1233100002963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1233100002964 hypothetical protein; Provisional; Region: PRK13676 1233100002965 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1233100002966 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1233100002967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100002968 active site 1233100002969 motif I; other site 1233100002970 motif II; other site 1233100002971 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1233100002972 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1233100002973 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100002974 FeS/SAM binding site; other site 1233100002975 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1233100002976 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1233100002977 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1233100002978 TrkA-C domain; Region: TrkA_C; pfam02080 1233100002979 enoyl-CoA hydratase; Provisional; Region: PRK07659 1233100002980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233100002981 substrate binding site [chemical binding]; other site 1233100002982 oxyanion hole (OAH) forming residues; other site 1233100002983 trimer interface [polypeptide binding]; other site 1233100002984 YhzD-like protein; Region: YhzD; pfam14120 1233100002985 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1233100002986 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1233100002987 Walker A/P-loop; other site 1233100002988 ATP binding site [chemical binding]; other site 1233100002989 Q-loop/lid; other site 1233100002990 ABC transporter signature motif; other site 1233100002991 Walker B; other site 1233100002992 D-loop; other site 1233100002993 H-loop/switch region; other site 1233100002994 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1233100002995 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1233100002996 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1233100002997 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1233100002998 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1233100002999 active site 1233100003000 metal binding site [ion binding]; metal-binding site 1233100003001 DNA binding site [nucleotide binding] 1233100003002 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1233100003003 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1233100003004 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1233100003005 generic binding surface II; other site 1233100003006 generic binding surface I; other site 1233100003007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233100003008 Zn2+ binding site [ion binding]; other site 1233100003009 Mg2+ binding site [ion binding]; other site 1233100003010 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1233100003011 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1233100003012 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1233100003013 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1233100003014 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1233100003015 transcriptional regulator Hpr; Provisional; Region: PRK13777 1233100003016 MarR family; Region: MarR; pfam01047 1233100003017 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1233100003018 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1233100003019 homodimer interface [polypeptide binding]; other site 1233100003020 substrate-cofactor binding pocket; other site 1233100003021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100003022 catalytic residue [active] 1233100003023 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1233100003024 HIT family signature motif; other site 1233100003025 catalytic residue [active] 1233100003026 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1233100003027 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233100003028 Walker A/P-loop; other site 1233100003029 ATP binding site [chemical binding]; other site 1233100003030 Q-loop/lid; other site 1233100003031 ABC transporter signature motif; other site 1233100003032 Walker B; other site 1233100003033 D-loop; other site 1233100003034 H-loop/switch region; other site 1233100003035 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1233100003036 EcsC protein family; Region: EcsC; pfam12787 1233100003037 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1233100003038 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1233100003039 metal binding site [ion binding]; metal-binding site 1233100003040 dimer interface [polypeptide binding]; other site 1233100003041 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1233100003042 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1233100003043 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1233100003044 Transglycosylase; Region: Transgly; pfam00912 1233100003045 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233100003046 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1233100003047 substrate binding site [chemical binding]; other site 1233100003048 active site 1233100003049 ferrochelatase; Provisional; Region: PRK12435 1233100003050 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1233100003051 C-terminal domain interface [polypeptide binding]; other site 1233100003052 active site 1233100003053 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1233100003054 active site 1233100003055 N-terminal domain interface [polypeptide binding]; other site 1233100003056 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1233100003057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1233100003058 SEA domain; Region: SEA; cl02507 1233100003059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100003060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100003061 Predicted membrane protein [Function unknown]; Region: COG1511 1233100003062 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1233100003063 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1233100003064 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1233100003065 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1233100003066 dimer interface [polypeptide binding]; other site 1233100003067 active site 1233100003068 CoA binding pocket [chemical binding]; other site 1233100003069 Predicted membrane protein [Function unknown]; Region: COG4377 1233100003070 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1233100003071 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1233100003072 putative oligomer interface [polypeptide binding]; other site 1233100003073 putative active site [active] 1233100003074 metal binding site [ion binding]; metal-binding site 1233100003075 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1233100003076 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1233100003077 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1233100003078 YhfH-like protein; Region: YhfH; pfam14149 1233100003079 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1233100003080 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1233100003081 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1233100003082 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1233100003083 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1233100003084 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1233100003085 NAD(P) binding site [chemical binding]; other site 1233100003086 putative active site [active] 1233100003087 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1233100003088 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1233100003089 acyl-activating enzyme (AAE) consensus motif; other site 1233100003090 putative AMP binding site [chemical binding]; other site 1233100003091 putative active site [active] 1233100003092 putative CoA binding site [chemical binding]; other site 1233100003093 Peptidase family M48; Region: Peptidase_M48; pfam01435 1233100003094 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1233100003095 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1233100003096 active site 1233100003097 catalytic residues [active] 1233100003098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100003099 Coenzyme A binding pocket [chemical binding]; other site 1233100003100 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1233100003101 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1233100003102 putative NADP binding site [chemical binding]; other site 1233100003103 putative dimer interface [polypeptide binding]; other site 1233100003104 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1233100003105 catalytic core [active] 1233100003106 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1233100003107 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233100003108 dimer interface [polypeptide binding]; other site 1233100003109 active site 1233100003110 acyl-CoA synthetase; Validated; Region: PRK07638 1233100003111 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233100003112 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1233100003113 acyl-activating enzyme (AAE) consensus motif; other site 1233100003114 acyl-activating enzyme (AAE) consensus motif; other site 1233100003115 AMP binding site [chemical binding]; other site 1233100003116 active site 1233100003117 CoA binding site [chemical binding]; other site 1233100003118 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1233100003119 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1233100003120 heme-binding site [chemical binding]; other site 1233100003121 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233100003122 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100003123 dimer interface [polypeptide binding]; other site 1233100003124 putative CheW interface [polypeptide binding]; other site 1233100003125 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1233100003126 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1233100003127 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1233100003128 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1233100003129 [2Fe-2S] cluster binding site [ion binding]; other site 1233100003130 short chain dehydrogenase; Provisional; Region: PRK06701 1233100003131 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1233100003132 NAD binding site [chemical binding]; other site 1233100003133 metal binding site [ion binding]; metal-binding site 1233100003134 active site 1233100003135 IDEAL domain; Region: IDEAL; pfam08858 1233100003136 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1233100003137 oxidoreductase; Provisional; Region: PRK07985 1233100003138 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1233100003139 NAD binding site [chemical binding]; other site 1233100003140 metal binding site [ion binding]; metal-binding site 1233100003141 active site 1233100003142 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1233100003143 Na binding site [ion binding]; other site 1233100003144 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1233100003145 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1233100003146 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233100003147 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1233100003148 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1233100003149 Catalytic site [active] 1233100003150 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1233100003151 hypothetical protein; Provisional; Region: PRK08244 1233100003152 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1233100003153 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100003154 MarR family; Region: MarR; pfam01047 1233100003155 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1233100003156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100003157 putative substrate translocation pore; other site 1233100003158 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233100003159 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233100003160 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233100003161 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1233100003162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100003163 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1233100003164 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1233100003165 inhibitor-cofactor binding pocket; inhibition site 1233100003166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100003167 catalytic residue [active] 1233100003168 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100003169 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100003170 DNA binding site [nucleotide binding] 1233100003171 domain linker motif; other site 1233100003172 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1233100003173 putative dimerization interface [polypeptide binding]; other site 1233100003174 putative ligand binding site [chemical binding]; other site 1233100003175 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1233100003176 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1233100003177 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1233100003178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100003179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100003180 putative substrate translocation pore; other site 1233100003181 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1233100003182 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1233100003183 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1233100003184 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1233100003185 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1233100003186 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1233100003187 dinuclear metal binding motif [ion binding]; other site 1233100003188 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1233100003189 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1233100003190 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1233100003191 Part of AAA domain; Region: AAA_19; pfam13245 1233100003192 Family description; Region: UvrD_C_2; pfam13538 1233100003193 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1233100003194 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1233100003195 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1233100003196 active site 1233100003197 metal binding site [ion binding]; metal-binding site 1233100003198 DNA binding site [nucleotide binding] 1233100003199 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1233100003200 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1233100003201 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1233100003202 Walker A/P-loop; other site 1233100003203 ATP binding site [chemical binding]; other site 1233100003204 Q-loop/lid; other site 1233100003205 ABC transporter signature motif; other site 1233100003206 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1233100003207 ABC transporter signature motif; other site 1233100003208 Walker B; other site 1233100003209 D-loop; other site 1233100003210 H-loop/switch region; other site 1233100003211 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1233100003212 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233100003213 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1233100003214 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1233100003215 Spore germination protein GerPC; Region: GerPC; pfam10737 1233100003216 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233100003217 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1233100003218 CotH protein; Region: CotH; pfam08757 1233100003219 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1233100003220 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1233100003221 hypothetical protein; Provisional; Region: PRK13673 1233100003222 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1233100003223 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1233100003224 active site 1233100003225 catalytic triad [active] 1233100003226 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1233100003227 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1233100003228 active site 1233100003229 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1233100003230 dimer interface [polypeptide binding]; other site 1233100003231 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1233100003232 Ligand Binding Site [chemical binding]; other site 1233100003233 Molecular Tunnel; other site 1233100003234 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1233100003235 substrate binding pocket [chemical binding]; other site 1233100003236 aspartate-rich region 2; other site 1233100003237 substrate-Mg2+ binding site; other site 1233100003238 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1233100003239 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1233100003240 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1233100003241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100003242 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233100003243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100003244 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100003245 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100003246 DNA binding site [nucleotide binding] 1233100003247 domain linker motif; other site 1233100003248 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1233100003249 dimerization interface [polypeptide binding]; other site 1233100003250 ligand binding site [chemical binding]; other site 1233100003251 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233100003252 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233100003253 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233100003254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1233100003255 Lysine efflux permease [General function prediction only]; Region: COG1279 1233100003256 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1233100003257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100003258 DNA-binding site [nucleotide binding]; DNA binding site 1233100003259 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100003260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100003261 homodimer interface [polypeptide binding]; other site 1233100003262 catalytic residue [active] 1233100003263 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1233100003264 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1233100003265 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1233100003266 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100003267 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1233100003268 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1233100003269 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1233100003270 ligand-binding site [chemical binding]; other site 1233100003271 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1233100003272 ATP-sulfurylase; Region: ATPS; cd00517 1233100003273 active site 1233100003274 HXXH motif; other site 1233100003275 flexible loop; other site 1233100003276 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1233100003277 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1233100003278 Active Sites [active] 1233100003279 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1233100003280 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1233100003281 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1233100003282 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233100003283 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100003284 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1233100003285 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1233100003286 active site pocket [active] 1233100003287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100003288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100003289 putative substrate translocation pore; other site 1233100003290 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1233100003291 Coenzyme A binding pocket [chemical binding]; other site 1233100003292 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1233100003293 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1233100003294 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1233100003295 FAD binding site [chemical binding]; other site 1233100003296 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 1233100003297 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 1233100003298 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1233100003299 S1 domain; Region: S1_2; pfam13509 1233100003300 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1233100003301 RNA binding site [nucleotide binding]; other site 1233100003302 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1233100003303 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1233100003304 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1233100003305 Predicted transcriptional regulators [Transcription]; Region: COG1695 1233100003306 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1233100003307 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1233100003308 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1233100003309 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1233100003310 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1233100003311 active site 1233100003312 Zn binding site [ion binding]; other site 1233100003313 EDD domain protein, DegV family; Region: DegV; TIGR00762 1233100003314 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1233100003315 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233100003316 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100003317 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100003318 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233100003319 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1233100003320 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1233100003321 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1233100003322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100003323 motif II; other site 1233100003324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100003325 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1233100003326 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1233100003327 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1233100003328 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1233100003329 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1233100003330 FAD binding domain; Region: FAD_binding_4; pfam01565 1233100003331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100003332 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100003333 putative substrate translocation pore; other site 1233100003334 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1233100003335 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1233100003336 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1233100003337 heterotetramer interface [polypeptide binding]; other site 1233100003338 active site pocket [active] 1233100003339 cleavage site 1233100003340 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1233100003341 substrate binding site [chemical binding]; other site 1233100003342 nucleotide binding site [chemical binding]; other site 1233100003343 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1233100003344 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233100003345 inhibitor-cofactor binding pocket; inhibition site 1233100003346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100003347 catalytic residue [active] 1233100003348 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1233100003349 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1233100003350 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1233100003351 catalytic site [active] 1233100003352 subunit interface [polypeptide binding]; other site 1233100003353 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1233100003354 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233100003355 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1233100003356 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1233100003357 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233100003358 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1233100003359 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1233100003360 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1233100003361 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1233100003362 YjzC-like protein; Region: YjzC; pfam14168 1233100003363 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1233100003364 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1233100003365 UDP-apiose/xylose synthase; Region: PLN02427 1233100003366 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1233100003367 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1233100003368 putative ligand binding site [chemical binding]; other site 1233100003369 ComZ; Region: ComZ; pfam10815 1233100003370 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1233100003371 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1233100003372 dimer interface [polypeptide binding]; other site 1233100003373 active site 1233100003374 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1233100003375 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1233100003376 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233100003377 Walker A/P-loop; other site 1233100003378 ATP binding site [chemical binding]; other site 1233100003379 Q-loop/lid; other site 1233100003380 ABC transporter signature motif; other site 1233100003381 Walker B; other site 1233100003382 D-loop; other site 1233100003383 H-loop/switch region; other site 1233100003384 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1233100003385 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1233100003386 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233100003387 Walker A/P-loop; other site 1233100003388 ATP binding site [chemical binding]; other site 1233100003389 Q-loop/lid; other site 1233100003390 ABC transporter signature motif; other site 1233100003391 Walker B; other site 1233100003392 D-loop; other site 1233100003393 H-loop/switch region; other site 1233100003394 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1233100003395 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1233100003396 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1233100003397 peptide binding site [polypeptide binding]; other site 1233100003398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1233100003399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100003400 dimer interface [polypeptide binding]; other site 1233100003401 conserved gate region; other site 1233100003402 putative PBP binding loops; other site 1233100003403 ABC-ATPase subunit interface; other site 1233100003404 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1233100003405 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1233100003406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100003407 dimer interface [polypeptide binding]; other site 1233100003408 conserved gate region; other site 1233100003409 putative PBP binding loops; other site 1233100003410 ABC-ATPase subunit interface; other site 1233100003411 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1233100003412 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1233100003413 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1233100003414 active site 1233100003415 HIGH motif; other site 1233100003416 dimer interface [polypeptide binding]; other site 1233100003417 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1233100003418 KMSKS motif; other site 1233100003419 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1233100003420 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1233100003421 peptide binding site [polypeptide binding]; other site 1233100003422 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1233100003423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100003424 dimer interface [polypeptide binding]; other site 1233100003425 conserved gate region; other site 1233100003426 putative PBP binding loops; other site 1233100003427 ABC-ATPase subunit interface; other site 1233100003428 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1233100003429 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1233100003430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100003431 dimer interface [polypeptide binding]; other site 1233100003432 conserved gate region; other site 1233100003433 putative PBP binding loops; other site 1233100003434 ABC-ATPase subunit interface; other site 1233100003435 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1233100003436 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233100003437 Walker A/P-loop; other site 1233100003438 ATP binding site [chemical binding]; other site 1233100003439 Q-loop/lid; other site 1233100003440 ABC transporter signature motif; other site 1233100003441 Walker B; other site 1233100003442 D-loop; other site 1233100003443 H-loop/switch region; other site 1233100003444 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1233100003445 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1233100003446 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233100003447 Walker A/P-loop; other site 1233100003448 ATP binding site [chemical binding]; other site 1233100003449 Q-loop/lid; other site 1233100003450 ABC transporter signature motif; other site 1233100003451 Walker B; other site 1233100003452 D-loop; other site 1233100003453 H-loop/switch region; other site 1233100003454 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1233100003455 H+ Antiporter protein; Region: 2A0121; TIGR00900 1233100003456 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1233100003457 ArsC family; Region: ArsC; pfam03960 1233100003458 putative catalytic residues [active] 1233100003459 thiol/disulfide switch; other site 1233100003460 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1233100003461 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1233100003462 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 1233100003463 oligoendopeptidase F; Region: pepF; TIGR00181 1233100003464 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1233100003465 active site 1233100003466 Zn binding site [ion binding]; other site 1233100003467 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1233100003468 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1233100003469 catalytic residues [active] 1233100003470 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1233100003471 apolar tunnel; other site 1233100003472 heme binding site [chemical binding]; other site 1233100003473 dimerization interface [polypeptide binding]; other site 1233100003474 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1233100003475 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1233100003476 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1233100003477 catalytic residue [active] 1233100003478 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1233100003479 putative active site [active] 1233100003480 putative metal binding residues [ion binding]; other site 1233100003481 signature motif; other site 1233100003482 putative triphosphate binding site [ion binding]; other site 1233100003483 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1233100003484 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1233100003485 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1233100003486 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1233100003487 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1233100003488 active site 1233100003489 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1233100003490 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1233100003491 active site 1233100003492 metal binding site [ion binding]; metal-binding site 1233100003493 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1233100003494 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1233100003495 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1233100003496 TrkA-N domain; Region: TrkA_N; pfam02254 1233100003497 TrkA-C domain; Region: TrkA_C; pfam02080 1233100003498 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1233100003499 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1233100003500 thiamine phosphate binding site [chemical binding]; other site 1233100003501 active site 1233100003502 pyrophosphate binding site [ion binding]; other site 1233100003503 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1233100003504 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1233100003505 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1233100003506 thiS-thiF/thiG interaction site; other site 1233100003507 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1233100003508 ThiS interaction site; other site 1233100003509 putative active site [active] 1233100003510 tetramer interface [polypeptide binding]; other site 1233100003511 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1233100003512 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1233100003513 ATP binding site [chemical binding]; other site 1233100003514 substrate interface [chemical binding]; other site 1233100003515 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1233100003516 dimer interface [polypeptide binding]; other site 1233100003517 substrate binding site [chemical binding]; other site 1233100003518 ATP binding site [chemical binding]; other site 1233100003519 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1233100003520 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1233100003521 NAD binding site [chemical binding]; other site 1233100003522 homotetramer interface [polypeptide binding]; other site 1233100003523 homodimer interface [polypeptide binding]; other site 1233100003524 substrate binding site [chemical binding]; other site 1233100003525 active site 1233100003526 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1233100003527 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1233100003528 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1233100003529 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1233100003530 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1233100003531 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1233100003532 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1233100003533 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1233100003534 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1233100003535 Part of AAA domain; Region: AAA_19; pfam13245 1233100003536 Family description; Region: UvrD_C_2; pfam13538 1233100003537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100003538 Coenzyme A binding pocket [chemical binding]; other site 1233100003539 hypothetical protein; Provisional; Region: PRK13679 1233100003540 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1233100003541 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1233100003542 Putative esterase; Region: Esterase; pfam00756 1233100003543 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1233100003544 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1233100003545 homodimer interface [polypeptide binding]; other site 1233100003546 substrate-cofactor binding pocket; other site 1233100003547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100003548 catalytic residue [active] 1233100003549 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1233100003550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1233100003551 Predicted integral membrane protein [Function unknown]; Region: COG5505 1233100003552 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1233100003553 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1233100003554 HTH domain; Region: HTH_11; pfam08279 1233100003555 Mga helix-turn-helix domain; Region: Mga; pfam05043 1233100003556 PRD domain; Region: PRD; pfam00874 1233100003557 PRD domain; Region: PRD; pfam00874 1233100003558 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1233100003559 active site 1233100003560 P-loop; other site 1233100003561 phosphorylation site [posttranslational modification] 1233100003562 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1233100003563 active site 1233100003564 phosphorylation site [posttranslational modification] 1233100003565 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1233100003566 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1233100003567 active site 1233100003568 P-loop; other site 1233100003569 phosphorylation site [posttranslational modification] 1233100003570 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1233100003571 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1233100003572 active site 1233100003573 phosphorylation site [posttranslational modification] 1233100003574 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1233100003575 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1233100003576 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1233100003577 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1233100003578 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1233100003579 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1233100003580 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1233100003581 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 1233100003582 UbiA prenyltransferase family; Region: UbiA; pfam01040 1233100003583 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1233100003584 Putative motility protein; Region: YjfB_motility; pfam14070 1233100003585 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1233100003586 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1233100003587 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1233100003588 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1233100003589 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1233100003590 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1233100003591 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1233100003592 4Fe-4S binding domain; Region: Fer4; pfam00037 1233100003593 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1233100003594 [4Fe-4S] binding site [ion binding]; other site 1233100003595 molybdopterin cofactor binding site; other site 1233100003596 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1233100003597 molybdopterin cofactor binding site; other site 1233100003598 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1233100003599 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1233100003600 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1233100003601 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1233100003602 nudix motif; other site 1233100003603 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1233100003604 Cytochrome P450; Region: p450; cl12078 1233100003605 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1233100003606 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1233100003607 active site 1233100003608 TDP-binding site; other site 1233100003609 acceptor substrate-binding pocket; other site 1233100003610 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1233100003611 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1233100003612 active site 1233100003613 TIGR00245 family protein; Region: TIGR00245 1233100003614 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1233100003615 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1233100003616 Walker A/P-loop; other site 1233100003617 ATP binding site [chemical binding]; other site 1233100003618 Q-loop/lid; other site 1233100003619 ABC transporter signature motif; other site 1233100003620 Walker B; other site 1233100003621 D-loop; other site 1233100003622 H-loop/switch region; other site 1233100003623 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1233100003624 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1233100003625 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1233100003626 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1233100003627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100003628 Glucuronate isomerase; Region: UxaC; pfam02614 1233100003629 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1233100003630 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1233100003631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100003632 putative substrate translocation pore; other site 1233100003633 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 1233100003634 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1233100003635 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1233100003636 putative NAD(P) binding site [chemical binding]; other site 1233100003637 catalytic Zn binding site [ion binding]; other site 1233100003638 structural Zn binding site [ion binding]; other site 1233100003639 mannonate dehydratase; Provisional; Region: PRK03906 1233100003640 mannonate dehydratase; Region: uxuA; TIGR00695 1233100003641 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1233100003642 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1233100003643 putative NAD(P) binding site [chemical binding]; other site 1233100003644 active site 1233100003645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100003646 D-galactonate transporter; Region: 2A0114; TIGR00893 1233100003647 putative substrate translocation pore; other site 1233100003648 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100003649 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100003650 DNA binding site [nucleotide binding] 1233100003651 domain linker motif; other site 1233100003652 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1233100003653 dimerization interface [polypeptide binding]; other site 1233100003654 ligand binding site [chemical binding]; other site 1233100003655 altronate oxidoreductase; Provisional; Region: PRK03643 1233100003656 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1233100003657 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1233100003658 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1233100003659 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1233100003660 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1233100003661 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1233100003662 DinB family; Region: DinB; pfam05163 1233100003663 DinB superfamily; Region: DinB_2; pfam12867 1233100003664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100003665 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1233100003666 Walker A motif; other site 1233100003667 ATP binding site [chemical binding]; other site 1233100003668 Walker B motif; other site 1233100003669 arginine finger; other site 1233100003670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100003671 binding surface 1233100003672 TPR motif; other site 1233100003673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233100003674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100003675 binding surface 1233100003676 TPR motif; other site 1233100003677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1233100003678 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1233100003679 pentamer interface [polypeptide binding]; other site 1233100003680 dodecaamer interface [polypeptide binding]; other site 1233100003681 Phage-related replication protein [General function prediction only]; Region: COG4195 1233100003682 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1233100003683 dimanganese center [ion binding]; other site 1233100003684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1233100003685 putative Zn2+ binding site [ion binding]; other site 1233100003686 putative DNA binding site [nucleotide binding]; other site 1233100003687 hypothetical protein; Provisional; Region: PRK06921 1233100003688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100003689 Walker A motif; other site 1233100003690 ATP binding site [chemical binding]; other site 1233100003691 Walker B motif; other site 1233100003692 positive control sigma-like factor; Validated; Region: PRK06930 1233100003693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100003694 DNA binding residues [nucleotide binding] 1233100003695 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1233100003696 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1233100003697 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1233100003698 Phage capsid family; Region: Phage_capsid; pfam05065 1233100003699 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1233100003700 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1233100003701 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1233100003702 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1233100003703 Phage XkdN-like protein; Region: XkdN; pfam08890 1233100003704 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1233100003705 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1233100003706 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1233100003707 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1233100003708 catalytic residue [active] 1233100003709 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1233100003710 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100003711 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1233100003712 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1233100003713 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1233100003714 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1233100003715 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1233100003716 XkdW protein; Region: XkdW; pfam09636 1233100003717 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1233100003718 Haemolysin XhlA; Region: XhlA; pfam10779 1233100003719 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1233100003720 amidase catalytic site [active] 1233100003721 Zn binding residues [ion binding]; other site 1233100003722 substrate binding site [chemical binding]; other site 1233100003723 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233100003724 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100003725 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1233100003726 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233100003727 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1233100003728 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1233100003729 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1233100003730 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1233100003731 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1233100003732 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1233100003733 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100003734 Zn binding site [ion binding]; other site 1233100003735 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1233100003736 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100003737 Zn binding site [ion binding]; other site 1233100003738 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1233100003739 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1233100003740 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1233100003741 Trypsin; Region: Trypsin; pfam00089 1233100003742 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1233100003743 protein binding site [polypeptide binding]; other site 1233100003744 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 1233100003745 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1233100003746 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1233100003747 SxDxEG motif; other site 1233100003748 active site 1233100003749 metal binding site [ion binding]; metal-binding site 1233100003750 homopentamer interface [polypeptide binding]; other site 1233100003751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1233100003752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100003753 dimer interface [polypeptide binding]; other site 1233100003754 conserved gate region; other site 1233100003755 putative PBP binding loops; other site 1233100003756 ABC-ATPase subunit interface; other site 1233100003757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1233100003758 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1233100003759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100003760 dimer interface [polypeptide binding]; other site 1233100003761 conserved gate region; other site 1233100003762 putative PBP binding loops; other site 1233100003763 ABC-ATPase subunit interface; other site 1233100003764 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1233100003765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1233100003766 Walker A/P-loop; other site 1233100003767 ATP binding site [chemical binding]; other site 1233100003768 Q-loop/lid; other site 1233100003769 ABC transporter signature motif; other site 1233100003770 Walker B; other site 1233100003771 D-loop; other site 1233100003772 H-loop/switch region; other site 1233100003773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1233100003774 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1233100003775 dimer interface [polypeptide binding]; other site 1233100003776 catalytic triad [active] 1233100003777 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1233100003778 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1233100003779 active site 1233100003780 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233100003781 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233100003782 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1233100003783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100003784 Walker B; other site 1233100003785 D-loop; other site 1233100003786 H-loop/switch region; other site 1233100003787 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1233100003788 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1233100003789 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1233100003790 Amidinotransferase; Region: Amidinotransf; pfam02274 1233100003791 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1233100003792 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1233100003793 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1233100003794 heme-binding site [chemical binding]; other site 1233100003795 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1233100003796 FAD binding pocket [chemical binding]; other site 1233100003797 FAD binding motif [chemical binding]; other site 1233100003798 phosphate binding motif [ion binding]; other site 1233100003799 beta-alpha-beta structure motif; other site 1233100003800 NAD binding pocket [chemical binding]; other site 1233100003801 Heme binding pocket [chemical binding]; other site 1233100003802 Predicted membrane protein [Function unknown]; Region: COG2323 1233100003803 DinB superfamily; Region: DinB_2; pfam12867 1233100003804 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1233100003805 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1233100003806 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1233100003807 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1233100003808 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1233100003809 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1233100003810 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1233100003811 putative active site [active] 1233100003812 putative substrate binding site [chemical binding]; other site 1233100003813 putative cosubstrate binding site; other site 1233100003814 catalytic site [active] 1233100003815 glutamate 5-kinase; Region: proB; TIGR01027 1233100003816 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1233100003817 nucleotide binding site [chemical binding]; other site 1233100003818 homotetrameric interface [polypeptide binding]; other site 1233100003819 putative phosphate binding site [ion binding]; other site 1233100003820 putative allosteric binding site; other site 1233100003821 PUA domain; Region: PUA; pfam01472 1233100003822 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1233100003823 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1233100003824 putative catalytic cysteine [active] 1233100003825 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1233100003826 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1233100003827 MarR family; Region: MarR; pfam01047 1233100003828 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1233100003829 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1233100003830 nucleoside/Zn binding site; other site 1233100003831 dimer interface [polypeptide binding]; other site 1233100003832 catalytic motif [active] 1233100003833 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1233100003834 catalytic core [active] 1233100003835 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1233100003836 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1233100003837 THF binding site; other site 1233100003838 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1233100003839 substrate binding site [chemical binding]; other site 1233100003840 THF binding site; other site 1233100003841 zinc-binding site [ion binding]; other site 1233100003842 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1233100003843 active site 1233100003844 catalytic residues [active] 1233100003845 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1233100003846 Cobalt transport protein; Region: CbiQ; pfam02361 1233100003847 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1233100003848 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233100003849 Walker A/P-loop; other site 1233100003850 ATP binding site [chemical binding]; other site 1233100003851 Q-loop/lid; other site 1233100003852 ABC transporter signature motif; other site 1233100003853 Walker B; other site 1233100003854 D-loop; other site 1233100003855 H-loop/switch region; other site 1233100003856 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233100003857 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1233100003858 Walker A/P-loop; other site 1233100003859 ATP binding site [chemical binding]; other site 1233100003860 Q-loop/lid; other site 1233100003861 ABC transporter signature motif; other site 1233100003862 Walker B; other site 1233100003863 D-loop; other site 1233100003864 H-loop/switch region; other site 1233100003865 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1233100003866 YKOF-related Family; Region: Ykof; pfam07615 1233100003867 YKOF-related Family; Region: Ykof; pfam07615 1233100003868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100003869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100003870 active site 1233100003871 phosphorylation site [posttranslational modification] 1233100003872 intermolecular recognition site; other site 1233100003873 dimerization interface [polypeptide binding]; other site 1233100003874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100003875 DNA binding site [nucleotide binding] 1233100003876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100003877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100003878 dimerization interface [polypeptide binding]; other site 1233100003879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100003880 dimer interface [polypeptide binding]; other site 1233100003881 phosphorylation site [posttranslational modification] 1233100003882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100003883 ATP binding site [chemical binding]; other site 1233100003884 Mg2+ binding site [ion binding]; other site 1233100003885 G-X-G motif; other site 1233100003886 Predicted membrane protein [Function unknown]; Region: COG3212 1233100003887 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1233100003888 Predicted membrane protein [Function unknown]; Region: COG3212 1233100003889 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1233100003890 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1233100003891 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1233100003892 MgtE intracellular N domain; Region: MgtE_N; smart00924 1233100003893 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1233100003894 Divalent cation transporter; Region: MgtE; pfam01769 1233100003895 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1233100003896 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1233100003897 DNA binding residues [nucleotide binding] 1233100003898 putative dimer interface [polypeptide binding]; other site 1233100003899 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100003900 MarR family; Region: MarR; pfam01047 1233100003901 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1233100003902 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1233100003903 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1233100003904 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1233100003905 putative active site [active] 1233100003906 putative metal binding site [ion binding]; other site 1233100003907 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1233100003908 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1233100003909 Putative Catalytic site; other site 1233100003910 DXD motif; other site 1233100003911 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1233100003912 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1233100003913 active site 1233100003914 DNA binding site [nucleotide binding] 1233100003915 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1233100003916 nucleotide binding site [chemical binding]; other site 1233100003917 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1233100003918 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1233100003919 putative DNA binding site [nucleotide binding]; other site 1233100003920 putative homodimer interface [polypeptide binding]; other site 1233100003921 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1233100003922 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1233100003923 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1233100003924 PAS domain; Region: PAS_9; pfam13426 1233100003925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233100003926 metal binding site [ion binding]; metal-binding site 1233100003927 active site 1233100003928 I-site; other site 1233100003929 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1233100003930 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1233100003931 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233100003932 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1233100003933 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1233100003934 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100003935 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1233100003936 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1233100003937 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1233100003938 heat shock protein HtpX; Provisional; Region: PRK05457 1233100003939 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1233100003940 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1233100003941 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1233100003942 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1233100003943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100003944 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1233100003945 putative active site [active] 1233100003946 heme pocket [chemical binding]; other site 1233100003947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100003948 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1233100003949 putative active site [active] 1233100003950 heme pocket [chemical binding]; other site 1233100003951 PAS domain; Region: PAS; smart00091 1233100003952 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1233100003953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100003954 putative active site [active] 1233100003955 heme pocket [chemical binding]; other site 1233100003956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100003957 dimer interface [polypeptide binding]; other site 1233100003958 phosphorylation site [posttranslational modification] 1233100003959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100003960 ATP binding site [chemical binding]; other site 1233100003961 Mg2+ binding site [ion binding]; other site 1233100003962 G-X-G motif; other site 1233100003963 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1233100003964 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1233100003965 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1233100003966 DNA binding site [nucleotide binding] 1233100003967 active site 1233100003968 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1233100003969 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1233100003970 Predicted kinase [General function prediction only]; Region: COG4857 1233100003971 Phosphotransferase enzyme family; Region: APH; pfam01636 1233100003972 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1233100003973 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1233100003974 putative active site [active] 1233100003975 catalytic triad [active] 1233100003976 putative dimer interface [polypeptide binding]; other site 1233100003977 transaminase; Reviewed; Region: PRK08068 1233100003978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100003979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100003980 homodimer interface [polypeptide binding]; other site 1233100003981 catalytic residue [active] 1233100003982 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1233100003983 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1233100003984 dimer interface [polypeptide binding]; other site 1233100003985 active site 1233100003986 catalytic residue [active] 1233100003987 metal binding site [ion binding]; metal-binding site 1233100003988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100003989 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1233100003990 motif II; other site 1233100003991 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1233100003992 Cupin domain; Region: Cupin_2; pfam07883 1233100003993 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1233100003994 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1233100003995 Cache domain; Region: Cache_1; pfam02743 1233100003996 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1233100003997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100003998 dimer interface [polypeptide binding]; other site 1233100003999 phosphorylation site [posttranslational modification] 1233100004000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100004001 ATP binding site [chemical binding]; other site 1233100004002 Mg2+ binding site [ion binding]; other site 1233100004003 G-X-G motif; other site 1233100004004 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100004005 MarR family; Region: MarR; pfam01047 1233100004006 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1233100004007 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1233100004008 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1233100004009 ligand binding site [chemical binding]; other site 1233100004010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100004011 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1233100004012 Walker A motif; other site 1233100004013 ATP binding site [chemical binding]; other site 1233100004014 Walker B motif; other site 1233100004015 arginine finger; other site 1233100004016 UvrB/uvrC motif; Region: UVR; pfam02151 1233100004017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100004018 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1233100004019 Walker A motif; other site 1233100004020 ATP binding site [chemical binding]; other site 1233100004021 Walker B motif; other site 1233100004022 arginine finger; other site 1233100004023 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1233100004024 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1233100004025 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1233100004026 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1233100004027 Ligand Binding Site [chemical binding]; other site 1233100004028 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1233100004029 active site 1233100004030 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1233100004031 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100004032 FeS/SAM binding site; other site 1233100004033 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1233100004034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1233100004035 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1233100004036 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1233100004037 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233100004038 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100004039 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1233100004040 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1233100004041 active site 1233100004042 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1233100004043 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1233100004044 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1233100004045 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1233100004046 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1233100004047 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1233100004048 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233100004049 catalytic residues [active] 1233100004050 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1233100004051 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1233100004052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100004053 motif II; other site 1233100004054 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1233100004055 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1233100004056 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1233100004057 active site 1233100004058 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100004059 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100004060 DNA binding site [nucleotide binding] 1233100004061 domain linker motif; other site 1233100004062 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1233100004063 putative dimerization interface [polypeptide binding]; other site 1233100004064 putative ligand binding site [chemical binding]; other site 1233100004065 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1233100004066 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1233100004067 PRD domain; Region: PRD; pfam00874 1233100004068 PRD domain; Region: PRD; pfam00874 1233100004069 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233100004070 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1233100004071 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233100004072 active site turn [active] 1233100004073 phosphorylation site [posttranslational modification] 1233100004074 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1233100004075 HPr interaction site; other site 1233100004076 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1233100004077 active site 1233100004078 phosphorylation site [posttranslational modification] 1233100004079 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1233100004080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1233100004081 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1233100004082 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1233100004083 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1233100004084 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1233100004085 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1233100004086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100004087 FeS/SAM binding site; other site 1233100004088 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1233100004089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100004090 Coenzyme A binding pocket [chemical binding]; other site 1233100004091 Cache domain; Region: Cache_1; pfam02743 1233100004092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100004093 dimerization interface [polypeptide binding]; other site 1233100004094 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233100004095 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100004096 dimer interface [polypeptide binding]; other site 1233100004097 putative CheW interface [polypeptide binding]; other site 1233100004098 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1233100004099 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1233100004100 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1233100004101 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1233100004102 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233100004103 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233100004104 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1233100004105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233100004106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100004107 putative active site [active] 1233100004108 heme pocket [chemical binding]; other site 1233100004109 PAS fold; Region: PAS; pfam00989 1233100004110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100004111 putative active site [active] 1233100004112 heme pocket [chemical binding]; other site 1233100004113 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1233100004114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100004115 putative active site [active] 1233100004116 heme pocket [chemical binding]; other site 1233100004117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100004118 dimer interface [polypeptide binding]; other site 1233100004119 phosphorylation site [posttranslational modification] 1233100004120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100004121 ATP binding site [chemical binding]; other site 1233100004122 Mg2+ binding site [ion binding]; other site 1233100004123 G-X-G motif; other site 1233100004124 aminotransferase A; Validated; Region: PRK07683 1233100004125 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100004126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100004127 homodimer interface [polypeptide binding]; other site 1233100004128 catalytic residue [active] 1233100004129 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1233100004130 putative CheA interaction surface; other site 1233100004131 Response regulator receiver domain; Region: Response_reg; pfam00072 1233100004132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100004133 active site 1233100004134 phosphorylation site [posttranslational modification] 1233100004135 intermolecular recognition site; other site 1233100004136 dimerization interface [polypeptide binding]; other site 1233100004137 YkyB-like protein; Region: YkyB; pfam14177 1233100004138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100004139 H+ Antiporter protein; Region: 2A0121; TIGR00900 1233100004140 putative substrate translocation pore; other site 1233100004141 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100004142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1233100004143 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1233100004144 phosphodiesterase YaeI; Provisional; Region: PRK11340 1233100004145 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1233100004146 putative active site [active] 1233100004147 putative metal binding site [ion binding]; other site 1233100004148 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1233100004149 short chain dehydrogenase; Provisional; Region: PRK07677 1233100004150 NAD(P) binding site [chemical binding]; other site 1233100004151 substrate binding site [chemical binding]; other site 1233100004152 homotetramer interface [polypeptide binding]; other site 1233100004153 active site 1233100004154 homodimer interface [polypeptide binding]; other site 1233100004155 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1233100004156 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1233100004157 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1233100004158 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1233100004159 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1233100004160 FOG: CBS domain [General function prediction only]; Region: COG0517 1233100004161 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1233100004162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100004163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100004164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233100004165 dimerization interface [polypeptide binding]; other site 1233100004166 flavodoxin; Provisional; Region: PRK06703 1233100004167 BNR repeat-like domain; Region: BNR_2; pfam13088 1233100004168 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1233100004169 flavodoxin, short chain; Region: flav_short; TIGR01753 1233100004170 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1233100004171 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1233100004172 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1233100004173 active site 1233100004174 trimer interface [polypeptide binding]; other site 1233100004175 substrate binding site [chemical binding]; other site 1233100004176 CoA binding site [chemical binding]; other site 1233100004177 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1233100004178 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1233100004179 metal binding site [ion binding]; metal-binding site 1233100004180 putative dimer interface [polypeptide binding]; other site 1233100004181 hypothetical protein; Provisional; Region: PRK03094 1233100004182 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1233100004183 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1233100004184 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1233100004185 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1233100004186 dimer interface [polypeptide binding]; other site 1233100004187 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1233100004188 catalytic triad [active] 1233100004189 peroxidatic and resolving cysteines [active] 1233100004190 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1233100004191 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233100004192 catalytic residues [active] 1233100004193 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1233100004194 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1233100004195 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1233100004196 GTP binding site; other site 1233100004197 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1233100004198 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1233100004199 ATP binding site [chemical binding]; other site 1233100004200 substrate interface [chemical binding]; other site 1233100004201 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1233100004202 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1233100004203 dimer interface [polypeptide binding]; other site 1233100004204 putative functional site; other site 1233100004205 putative MPT binding site; other site 1233100004206 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1233100004207 MoaE homodimer interface [polypeptide binding]; other site 1233100004208 MoaD interaction [polypeptide binding]; other site 1233100004209 active site residues [active] 1233100004210 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1233100004211 MoaE interaction surface [polypeptide binding]; other site 1233100004212 MoeB interaction surface [polypeptide binding]; other site 1233100004213 thiocarboxylated glycine; other site 1233100004214 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233100004215 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100004216 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1233100004217 Walker A/P-loop; other site 1233100004218 ATP binding site [chemical binding]; other site 1233100004219 Q-loop/lid; other site 1233100004220 ABC transporter signature motif; other site 1233100004221 Walker B; other site 1233100004222 D-loop; other site 1233100004223 H-loop/switch region; other site 1233100004224 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233100004225 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100004226 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1233100004227 Walker A/P-loop; other site 1233100004228 ATP binding site [chemical binding]; other site 1233100004229 Q-loop/lid; other site 1233100004230 ABC transporter signature motif; other site 1233100004231 Walker B; other site 1233100004232 D-loop; other site 1233100004233 H-loop/switch region; other site 1233100004234 Yip1 domain; Region: Yip1; pfam04893 1233100004235 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1233100004236 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1233100004237 HlyD family secretion protein; Region: HlyD_3; pfam13437 1233100004238 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1233100004239 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1233100004240 Walker A/P-loop; other site 1233100004241 ATP binding site [chemical binding]; other site 1233100004242 Q-loop/lid; other site 1233100004243 ABC transporter signature motif; other site 1233100004244 Walker B; other site 1233100004245 D-loop; other site 1233100004246 H-loop/switch region; other site 1233100004247 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1233100004248 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1233100004249 FtsX-like permease family; Region: FtsX; pfam02687 1233100004250 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1233100004251 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1233100004252 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1233100004253 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1233100004254 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1233100004255 putative substrate binding site [chemical binding]; other site 1233100004256 putative ATP binding site [chemical binding]; other site 1233100004257 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1233100004258 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1233100004259 active site 1233100004260 phosphorylation site [posttranslational modification] 1233100004261 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1233100004262 active site 1233100004263 P-loop; other site 1233100004264 phosphorylation site [posttranslational modification] 1233100004265 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1233100004266 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1233100004267 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1233100004268 Catalytic site [active] 1233100004269 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1233100004270 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100004271 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100004272 ABC transporter; Region: ABC_tran_2; pfam12848 1233100004273 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1233100004274 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1233100004275 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1233100004276 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1233100004277 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1233100004278 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1233100004279 rod-share determining protein MreBH; Provisional; Region: PRK13929 1233100004280 MreB and similar proteins; Region: MreB_like; cd10225 1233100004281 nucleotide binding site [chemical binding]; other site 1233100004282 Mg binding site [ion binding]; other site 1233100004283 putative protofilament interaction site [polypeptide binding]; other site 1233100004284 RodZ interaction site [polypeptide binding]; other site 1233100004285 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1233100004286 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1233100004287 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1233100004288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100004289 putative active site [active] 1233100004290 heme pocket [chemical binding]; other site 1233100004291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100004292 dimer interface [polypeptide binding]; other site 1233100004293 phosphorylation site [posttranslational modification] 1233100004294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100004295 ATP binding site [chemical binding]; other site 1233100004296 Mg2+ binding site [ion binding]; other site 1233100004297 G-X-G motif; other site 1233100004298 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1233100004299 putative active site pocket [active] 1233100004300 dimerization interface [polypeptide binding]; other site 1233100004301 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1233100004302 putative active site pocket [active] 1233100004303 dimerization interface [polypeptide binding]; other site 1233100004304 putative catalytic residue [active] 1233100004305 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1233100004306 TrkA-N domain; Region: TrkA_N; pfam02254 1233100004307 TrkA-C domain; Region: TrkA_C; pfam02080 1233100004308 adenine deaminase; Region: ade; TIGR01178 1233100004309 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1233100004310 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1233100004311 active site 1233100004312 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1233100004313 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1233100004314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1233100004315 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1233100004316 hypothetical protein; Provisional; Region: PRK13667 1233100004317 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1233100004318 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1233100004319 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1233100004320 TPP-binding site [chemical binding]; other site 1233100004321 tetramer interface [polypeptide binding]; other site 1233100004322 heterodimer interface [polypeptide binding]; other site 1233100004323 phosphorylation loop region [posttranslational modification] 1233100004324 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1233100004325 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1233100004326 alpha subunit interface [polypeptide binding]; other site 1233100004327 TPP binding site [chemical binding]; other site 1233100004328 heterodimer interface [polypeptide binding]; other site 1233100004329 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233100004330 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1233100004331 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1233100004332 E3 interaction surface; other site 1233100004333 lipoyl attachment site [posttranslational modification]; other site 1233100004334 e3 binding domain; Region: E3_binding; pfam02817 1233100004335 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1233100004336 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1233100004337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1233100004338 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100004339 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1233100004340 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1233100004341 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1233100004342 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1233100004343 homodimer interface [polypeptide binding]; other site 1233100004344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100004345 catalytic residue [active] 1233100004346 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1233100004347 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1233100004348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1233100004349 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1233100004350 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1233100004351 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1233100004352 active site 1233100004353 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1233100004354 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1233100004355 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1233100004356 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1233100004357 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1233100004358 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1233100004359 active site 1233100004360 Zn binding site [ion binding]; other site 1233100004361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100004362 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1233100004363 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100004364 DNA binding residues [nucleotide binding] 1233100004365 Putative zinc-finger; Region: zf-HC2; pfam13490 1233100004366 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1233100004367 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1233100004368 G1 box; other site 1233100004369 putative GEF interaction site [polypeptide binding]; other site 1233100004370 GTP/Mg2+ binding site [chemical binding]; other site 1233100004371 Switch I region; other site 1233100004372 G2 box; other site 1233100004373 G3 box; other site 1233100004374 Switch II region; other site 1233100004375 G4 box; other site 1233100004376 G5 box; other site 1233100004377 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1233100004378 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1233100004379 YlaH-like protein; Region: YlaH; pfam14036 1233100004380 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1233100004381 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1233100004382 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1233100004383 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1233100004384 putative active site [active] 1233100004385 PhoH-like protein; Region: PhoH; pfam02562 1233100004386 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1233100004387 glutaminase A; Region: Gln_ase; TIGR03814 1233100004388 hypothetical protein; Provisional; Region: PRK13666 1233100004389 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1233100004390 pyruvate carboxylase; Reviewed; Region: PRK12999 1233100004391 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233100004392 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1233100004393 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1233100004394 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1233100004395 active site 1233100004396 catalytic residues [active] 1233100004397 metal binding site [ion binding]; metal-binding site 1233100004398 homodimer binding site [polypeptide binding]; other site 1233100004399 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1233100004400 carboxyltransferase (CT) interaction site; other site 1233100004401 biotinylation site [posttranslational modification]; other site 1233100004402 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1233100004403 UbiA prenyltransferase family; Region: UbiA; pfam01040 1233100004404 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1233100004405 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1233100004406 Cytochrome c; Region: Cytochrom_C; pfam00034 1233100004407 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1233100004408 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1233100004409 D-pathway; other site 1233100004410 Putative ubiquinol binding site [chemical binding]; other site 1233100004411 Low-spin heme (heme b) binding site [chemical binding]; other site 1233100004412 Putative water exit pathway; other site 1233100004413 Binuclear center (heme o3/CuB) [ion binding]; other site 1233100004414 K-pathway; other site 1233100004415 Putative proton exit pathway; other site 1233100004416 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1233100004417 Subunit I/III interface [polypeptide binding]; other site 1233100004418 Subunit III/IV interface [polypeptide binding]; other site 1233100004419 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1233100004420 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1233100004421 YugN-like family; Region: YugN; pfam08868 1233100004422 FOG: CBS domain [General function prediction only]; Region: COG0517 1233100004423 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1233100004424 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1233100004425 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1233100004426 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1233100004427 Putative coat protein; Region: YlbD_coat; pfam14071 1233100004428 YlbE-like protein; Region: YlbE; pfam14003 1233100004429 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1233100004430 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1233100004431 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1233100004432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100004433 S-adenosylmethionine binding site [chemical binding]; other site 1233100004434 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1233100004435 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1233100004436 active site 1233100004437 (T/H)XGH motif; other site 1233100004438 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1233100004439 Nucleoside recognition; Region: Gate; pfam07670 1233100004440 Nucleoside recognition; Region: Gate; pfam07670 1233100004441 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1233100004442 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1233100004443 nucleophile elbow; other site 1233100004444 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1233100004445 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1233100004446 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1233100004447 protein binding site [polypeptide binding]; other site 1233100004448 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1233100004449 hypothetical protein; Provisional; Region: PRK13670 1233100004450 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1233100004451 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1233100004452 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1233100004453 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1233100004454 hypothetical protein; Provisional; Region: PRK13688 1233100004455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100004456 Coenzyme A binding pocket [chemical binding]; other site 1233100004457 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1233100004458 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1233100004459 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1233100004460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1233100004461 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1233100004462 mraZ protein; Region: TIGR00242 1233100004463 MraZ protein; Region: MraZ; pfam02381 1233100004464 MraZ protein; Region: MraZ; pfam02381 1233100004465 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1233100004466 MraW methylase family; Region: Methyltransf_5; pfam01795 1233100004467 Cell division protein FtsL; Region: FtsL; cl11433 1233100004468 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1233100004469 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233100004470 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233100004471 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1233100004472 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1233100004473 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1233100004474 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233100004475 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233100004476 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1233100004477 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1233100004478 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1233100004479 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233100004480 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233100004481 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1233100004482 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1233100004483 Mg++ binding site [ion binding]; other site 1233100004484 putative catalytic motif [active] 1233100004485 putative substrate binding site [chemical binding]; other site 1233100004486 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1233100004487 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233100004488 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233100004489 stage V sporulation protein E; Region: spoVE; TIGR02615 1233100004490 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1233100004491 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1233100004492 active site 1233100004493 homodimer interface [polypeptide binding]; other site 1233100004494 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1233100004495 FAD binding domain; Region: FAD_binding_4; pfam01565 1233100004496 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1233100004497 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1233100004498 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1233100004499 Cell division protein FtsQ; Region: FtsQ; pfam03799 1233100004500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1233100004501 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1233100004502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1233100004503 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1233100004504 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1233100004505 cell division protein FtsZ; Validated; Region: PRK09330 1233100004506 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1233100004507 nucleotide binding site [chemical binding]; other site 1233100004508 SulA interaction site; other site 1233100004509 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1233100004510 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1233100004511 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1233100004512 active site 1233100004513 catalytic triad [active] 1233100004514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1233100004515 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1233100004516 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1233100004517 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1233100004518 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1233100004519 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1233100004520 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1233100004521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100004522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100004523 DNA binding residues [nucleotide binding] 1233100004524 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1233100004525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100004526 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233100004527 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100004528 DNA binding residues [nucleotide binding] 1233100004529 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1233100004530 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1233100004531 Walker A/P-loop; other site 1233100004532 ATP binding site [chemical binding]; other site 1233100004533 Q-loop/lid; other site 1233100004534 ABC transporter signature motif; other site 1233100004535 Walker B; other site 1233100004536 D-loop; other site 1233100004537 H-loop/switch region; other site 1233100004538 acetylornithine deacetylase; Validated; Region: PRK08596 1233100004539 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1233100004540 metal binding site [ion binding]; metal-binding site 1233100004541 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1233100004542 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1233100004543 uncharacterized protein, YfiH family; Region: TIGR00726 1233100004544 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1233100004545 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1233100004546 catalytic residue [active] 1233100004547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1233100004548 YGGT family; Region: YGGT; pfam02325 1233100004549 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1233100004550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233100004551 RNA binding surface [nucleotide binding]; other site 1233100004552 DivIVA protein; Region: DivIVA; pfam05103 1233100004553 DivIVA domain; Region: DivI1A_domain; TIGR03544 1233100004554 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1233100004555 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1233100004556 HIGH motif; other site 1233100004557 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1233100004558 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1233100004559 active site 1233100004560 KMSKS motif; other site 1233100004561 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1233100004562 tRNA binding surface [nucleotide binding]; other site 1233100004563 anticodon binding site; other site 1233100004564 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1233100004565 lipoprotein signal peptidase; Region: lspA; TIGR00077 1233100004566 lipoprotein signal peptidase; Provisional; Region: PRK14787 1233100004567 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1233100004568 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233100004569 RNA binding surface [nucleotide binding]; other site 1233100004570 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1233100004571 active site 1233100004572 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1233100004573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100004574 active site 1233100004575 uracil-xanthine permease; Region: ncs2; TIGR00801 1233100004576 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1233100004577 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1233100004578 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1233100004579 dihydroorotase; Validated; Region: pyrC; PRK09357 1233100004580 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1233100004581 active site 1233100004582 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1233100004583 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1233100004584 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1233100004585 catalytic site [active] 1233100004586 subunit interface [polypeptide binding]; other site 1233100004587 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1233100004588 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233100004589 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1233100004590 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1233100004591 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233100004592 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1233100004593 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1233100004594 IMP binding site; other site 1233100004595 dimer interface [polypeptide binding]; other site 1233100004596 interdomain contacts; other site 1233100004597 partial ornithine binding site; other site 1233100004598 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1233100004599 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1233100004600 FAD binding pocket [chemical binding]; other site 1233100004601 FAD binding motif [chemical binding]; other site 1233100004602 phosphate binding motif [ion binding]; other site 1233100004603 beta-alpha-beta structure motif; other site 1233100004604 NAD binding pocket [chemical binding]; other site 1233100004605 Iron coordination center [ion binding]; other site 1233100004606 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1233100004607 active site 1233100004608 dimer interface [polypeptide binding]; other site 1233100004609 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100004610 active site 1233100004611 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1233100004612 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1233100004613 Active Sites [active] 1233100004614 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1233100004615 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1233100004616 ATP-sulfurylase; Region: ATPS; cd00517 1233100004617 active site 1233100004618 HXXH motif; other site 1233100004619 flexible loop; other site 1233100004620 AAA domain; Region: AAA_33; pfam13671 1233100004621 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1233100004622 ligand-binding site [chemical binding]; other site 1233100004623 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1233100004624 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1233100004625 active site 1233100004626 SAM binding site [chemical binding]; other site 1233100004627 homodimer interface [polypeptide binding]; other site 1233100004628 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1233100004629 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1233100004630 putative active site [active] 1233100004631 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1233100004632 putative active site [active] 1233100004633 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1233100004634 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1233100004635 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1233100004636 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1233100004637 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1233100004638 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1233100004639 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1233100004640 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1233100004641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100004642 motif II; other site 1233100004643 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1233100004644 TIGR00255 family protein; Region: TIGR00255 1233100004645 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1233100004646 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1233100004647 hypothetical protein; Provisional; Region: PRK04323 1233100004648 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1233100004649 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1233100004650 catalytic site [active] 1233100004651 G-X2-G-X-G-K; other site 1233100004652 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1233100004653 Flavoprotein; Region: Flavoprotein; pfam02441 1233100004654 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1233100004655 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1233100004656 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1233100004657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100004658 ATP binding site [chemical binding]; other site 1233100004659 putative Mg++ binding site [ion binding]; other site 1233100004660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100004661 nucleotide binding region [chemical binding]; other site 1233100004662 ATP-binding site [chemical binding]; other site 1233100004663 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1233100004664 active site 1233100004665 catalytic residues [active] 1233100004666 metal binding site [ion binding]; metal-binding site 1233100004667 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1233100004668 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1233100004669 putative active site [active] 1233100004670 substrate binding site [chemical binding]; other site 1233100004671 putative cosubstrate binding site; other site 1233100004672 catalytic site [active] 1233100004673 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1233100004674 substrate binding site [chemical binding]; other site 1233100004675 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1233100004676 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1233100004677 putative RNA binding site [nucleotide binding]; other site 1233100004678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100004679 S-adenosylmethionine binding site [chemical binding]; other site 1233100004680 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1233100004681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100004682 FeS/SAM binding site; other site 1233100004683 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1233100004684 Protein phosphatase 2C; Region: PP2C; pfam00481 1233100004685 active site 1233100004686 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1233100004687 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1233100004688 active site 1233100004689 ATP binding site [chemical binding]; other site 1233100004690 substrate binding site [chemical binding]; other site 1233100004691 activation loop (A-loop); other site 1233100004692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1233100004693 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1233100004694 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1233100004695 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1233100004696 GTPase RsgA; Reviewed; Region: PRK00098 1233100004697 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1233100004698 RNA binding site [nucleotide binding]; other site 1233100004699 homodimer interface [polypeptide binding]; other site 1233100004700 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1233100004701 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1233100004702 GTP/Mg2+ binding site [chemical binding]; other site 1233100004703 G4 box; other site 1233100004704 G5 box; other site 1233100004705 G1 box; other site 1233100004706 Switch I region; other site 1233100004707 G2 box; other site 1233100004708 G3 box; other site 1233100004709 Switch II region; other site 1233100004710 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1233100004711 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1233100004712 substrate binding site [chemical binding]; other site 1233100004713 hexamer interface [polypeptide binding]; other site 1233100004714 metal binding site [ion binding]; metal-binding site 1233100004715 Thiamine pyrophosphokinase; Region: TPK; cd07995 1233100004716 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1233100004717 active site 1233100004718 dimerization interface [polypeptide binding]; other site 1233100004719 thiamine binding site [chemical binding]; other site 1233100004720 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1233100004721 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1233100004722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1233100004723 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1233100004724 DAK2 domain; Region: Dak2; pfam02734 1233100004725 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1233100004726 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1233100004727 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1233100004728 putative L-serine binding site [chemical binding]; other site 1233100004729 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 1233100004730 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1233100004731 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1233100004732 Pathogenicity locus; Region: Cdd1; pfam11731 1233100004733 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1233100004734 generic binding surface II; other site 1233100004735 ssDNA binding site; other site 1233100004736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100004737 ATP binding site [chemical binding]; other site 1233100004738 putative Mg++ binding site [ion binding]; other site 1233100004739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100004740 nucleotide binding region [chemical binding]; other site 1233100004741 ATP-binding site [chemical binding]; other site 1233100004742 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1233100004743 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1233100004744 putative phosphate acyltransferase; Provisional; Region: PRK05331 1233100004745 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1233100004746 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1233100004747 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1233100004748 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1233100004749 NAD(P) binding site [chemical binding]; other site 1233100004750 homotetramer interface [polypeptide binding]; other site 1233100004751 homodimer interface [polypeptide binding]; other site 1233100004752 active site 1233100004753 acyl carrier protein; Provisional; Region: acpP; PRK00982 1233100004754 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1233100004755 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1233100004756 dimerization interface [polypeptide binding]; other site 1233100004757 active site 1233100004758 metal binding site [ion binding]; metal-binding site 1233100004759 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1233100004760 dsRNA binding site [nucleotide binding]; other site 1233100004761 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1233100004762 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1233100004763 Walker A/P-loop; other site 1233100004764 ATP binding site [chemical binding]; other site 1233100004765 Q-loop/lid; other site 1233100004766 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1233100004767 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1233100004768 ABC transporter signature motif; other site 1233100004769 Walker B; other site 1233100004770 D-loop; other site 1233100004771 H-loop/switch region; other site 1233100004772 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1233100004773 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1233100004774 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1233100004775 GTP binding site [chemical binding]; other site 1233100004776 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1233100004777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1233100004778 signal recognition particle protein; Provisional; Region: PRK10867 1233100004779 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1233100004780 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1233100004781 P loop; other site 1233100004782 GTP binding site [chemical binding]; other site 1233100004783 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1233100004784 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1233100004785 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1233100004786 KH domain; Region: KH_4; pfam13083 1233100004787 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1233100004788 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1233100004789 RimM N-terminal domain; Region: RimM; pfam01782 1233100004790 PRC-barrel domain; Region: PRC; pfam05239 1233100004791 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1233100004792 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1233100004793 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1233100004794 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1233100004795 GTP/Mg2+ binding site [chemical binding]; other site 1233100004796 G4 box; other site 1233100004797 G5 box; other site 1233100004798 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1233100004799 G1 box; other site 1233100004800 G1 box; other site 1233100004801 GTP/Mg2+ binding site [chemical binding]; other site 1233100004802 Switch I region; other site 1233100004803 G2 box; other site 1233100004804 G2 box; other site 1233100004805 G3 box; other site 1233100004806 G3 box; other site 1233100004807 Switch II region; other site 1233100004808 Switch II region; other site 1233100004809 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1233100004810 RNA/DNA hybrid binding site [nucleotide binding]; other site 1233100004811 active site 1233100004812 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1233100004813 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1233100004814 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1233100004815 CoA-ligase; Region: Ligase_CoA; pfam00549 1233100004816 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1233100004817 CoA binding domain; Region: CoA_binding; smart00881 1233100004818 CoA-ligase; Region: Ligase_CoA; pfam00549 1233100004819 DNA protecting protein DprA; Region: dprA; TIGR00732 1233100004820 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1233100004821 DNA topoisomerase I; Validated; Region: PRK05582 1233100004822 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1233100004823 active site 1233100004824 interdomain interaction site; other site 1233100004825 putative metal-binding site [ion binding]; other site 1233100004826 nucleotide binding site [chemical binding]; other site 1233100004827 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1233100004828 domain I; other site 1233100004829 DNA binding groove [nucleotide binding] 1233100004830 phosphate binding site [ion binding]; other site 1233100004831 domain II; other site 1233100004832 domain III; other site 1233100004833 nucleotide binding site [chemical binding]; other site 1233100004834 catalytic site [active] 1233100004835 domain IV; other site 1233100004836 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1233100004837 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1233100004838 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1233100004839 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1233100004840 active site 1233100004841 Int/Topo IB signature motif; other site 1233100004842 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1233100004843 active site 1233100004844 HslU subunit interaction site [polypeptide binding]; other site 1233100004845 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1233100004846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100004847 Walker A motif; other site 1233100004848 ATP binding site [chemical binding]; other site 1233100004849 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1233100004850 Walker B motif; other site 1233100004851 arginine finger; other site 1233100004852 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1233100004853 transcriptional repressor CodY; Validated; Region: PRK04158 1233100004854 CodY GAF-like domain; Region: CodY; pfam06018 1233100004855 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1233100004856 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1233100004857 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1233100004858 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1233100004859 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1233100004860 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1233100004861 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1233100004862 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1233100004863 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1233100004864 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1233100004865 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1233100004866 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1233100004867 MgtE intracellular N domain; Region: MgtE_N; smart00924 1233100004868 FliG C-terminal domain; Region: FliG_C; pfam01706 1233100004869 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1233100004870 Flagellar assembly protein FliH; Region: FliH; pfam02108 1233100004871 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1233100004872 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1233100004873 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1233100004874 Walker A motif/ATP binding site; other site 1233100004875 Walker B motif; other site 1233100004876 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1233100004877 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1233100004878 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1233100004879 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1233100004880 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1233100004881 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1233100004882 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1233100004883 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1233100004884 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1233100004885 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1233100004886 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 1233100004887 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1233100004888 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1233100004889 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1233100004890 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1233100004891 flagellar motor switch protein; Validated; Region: PRK08119 1233100004892 CheC-like family; Region: CheC; pfam04509 1233100004893 CheC-like family; Region: CheC; pfam04509 1233100004894 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1233100004895 Response regulator receiver domain; Region: Response_reg; pfam00072 1233100004896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100004897 active site 1233100004898 phosphorylation site [posttranslational modification] 1233100004899 intermolecular recognition site; other site 1233100004900 dimerization interface [polypeptide binding]; other site 1233100004901 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1233100004902 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1233100004903 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1233100004904 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1233100004905 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1233100004906 FHIPEP family; Region: FHIPEP; pfam00771 1233100004907 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1233100004908 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233100004909 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1233100004910 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1233100004911 P-loop; other site 1233100004912 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1233100004913 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1233100004914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100004915 active site 1233100004916 phosphorylation site [posttranslational modification] 1233100004917 intermolecular recognition site; other site 1233100004918 dimerization interface [polypeptide binding]; other site 1233100004919 CheB methylesterase; Region: CheB_methylest; pfam01339 1233100004920 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1233100004921 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1233100004922 putative binding surface; other site 1233100004923 active site 1233100004924 P2 response regulator binding domain; Region: P2; pfam07194 1233100004925 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1233100004926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100004927 ATP binding site [chemical binding]; other site 1233100004928 Mg2+ binding site [ion binding]; other site 1233100004929 G-X-G motif; other site 1233100004930 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1233100004931 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1233100004932 putative CheA interaction surface; other site 1233100004933 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1233100004934 CheC-like family; Region: CheC; pfam04509 1233100004935 CheC-like family; Region: CheC; pfam04509 1233100004936 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1233100004937 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1233100004938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100004939 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233100004940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100004941 DNA binding residues [nucleotide binding] 1233100004942 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1233100004943 rRNA interaction site [nucleotide binding]; other site 1233100004944 S8 interaction site; other site 1233100004945 putative laminin-1 binding site; other site 1233100004946 elongation factor Ts; Provisional; Region: tsf; PRK09377 1233100004947 UBA/TS-N domain; Region: UBA; pfam00627 1233100004948 Elongation factor TS; Region: EF_TS; pfam00889 1233100004949 Elongation factor TS; Region: EF_TS; pfam00889 1233100004950 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1233100004951 putative nucleotide binding site [chemical binding]; other site 1233100004952 uridine monophosphate binding site [chemical binding]; other site 1233100004953 homohexameric interface [polypeptide binding]; other site 1233100004954 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1233100004955 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1233100004956 hinge region; other site 1233100004957 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1233100004958 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1233100004959 catalytic residue [active] 1233100004960 putative FPP diphosphate binding site; other site 1233100004961 putative FPP binding hydrophobic cleft; other site 1233100004962 dimer interface [polypeptide binding]; other site 1233100004963 putative IPP diphosphate binding site; other site 1233100004964 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1233100004965 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1233100004966 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1233100004967 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1233100004968 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1233100004969 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1233100004970 RIP metalloprotease RseP; Region: TIGR00054 1233100004971 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1233100004972 active site 1233100004973 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1233100004974 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1233100004975 protein binding site [polypeptide binding]; other site 1233100004976 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1233100004977 putative substrate binding region [chemical binding]; other site 1233100004978 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1233100004979 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1233100004980 dimer interface [polypeptide binding]; other site 1233100004981 motif 1; other site 1233100004982 active site 1233100004983 motif 2; other site 1233100004984 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1233100004985 putative deacylase active site [active] 1233100004986 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1233100004987 active site 1233100004988 motif 3; other site 1233100004989 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1233100004990 anticodon binding site; other site 1233100004991 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1233100004992 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1233100004993 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1233100004994 generic binding surface II; other site 1233100004995 generic binding surface I; other site 1233100004996 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1233100004997 active site 1233100004998 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1233100004999 active site 1233100005000 catalytic site [active] 1233100005001 substrate binding site [chemical binding]; other site 1233100005002 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1233100005003 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1233100005004 Sm and related proteins; Region: Sm_like; cl00259 1233100005005 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1233100005006 putative oligomer interface [polypeptide binding]; other site 1233100005007 putative RNA binding site [nucleotide binding]; other site 1233100005008 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1233100005009 NusA N-terminal domain; Region: NusA_N; pfam08529 1233100005010 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1233100005011 RNA binding site [nucleotide binding]; other site 1233100005012 homodimer interface [polypeptide binding]; other site 1233100005013 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1233100005014 G-X-X-G motif; other site 1233100005015 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1233100005016 G-X-X-G motif; other site 1233100005017 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1233100005018 putative RNA binding cleft [nucleotide binding]; other site 1233100005019 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1233100005020 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1233100005021 translation initiation factor IF-2; Region: IF-2; TIGR00487 1233100005022 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1233100005023 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1233100005024 G1 box; other site 1233100005025 putative GEF interaction site [polypeptide binding]; other site 1233100005026 GTP/Mg2+ binding site [chemical binding]; other site 1233100005027 Switch I region; other site 1233100005028 G2 box; other site 1233100005029 G3 box; other site 1233100005030 Switch II region; other site 1233100005031 G4 box; other site 1233100005032 G5 box; other site 1233100005033 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1233100005034 Translation-initiation factor 2; Region: IF-2; pfam11987 1233100005035 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1233100005036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1233100005037 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1233100005038 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1233100005039 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1233100005040 RNA binding site [nucleotide binding]; other site 1233100005041 active site 1233100005042 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1233100005043 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1233100005044 active site 1233100005045 Riboflavin kinase; Region: Flavokinase; smart00904 1233100005046 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1233100005047 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1233100005048 RNase E interface [polypeptide binding]; other site 1233100005049 trimer interface [polypeptide binding]; other site 1233100005050 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1233100005051 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1233100005052 RNase E interface [polypeptide binding]; other site 1233100005053 trimer interface [polypeptide binding]; other site 1233100005054 active site 1233100005055 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1233100005056 putative nucleic acid binding region [nucleotide binding]; other site 1233100005057 G-X-X-G motif; other site 1233100005058 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1233100005059 RNA binding site [nucleotide binding]; other site 1233100005060 domain interface; other site 1233100005061 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1233100005062 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1233100005063 NodB motif; other site 1233100005064 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1233100005065 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1233100005066 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1233100005067 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1233100005068 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1233100005069 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1233100005070 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1233100005071 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1233100005072 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1233100005073 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1233100005074 aspartate kinase I; Reviewed; Region: PRK08210 1233100005075 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1233100005076 putative catalytic residues [active] 1233100005077 putative nucleotide binding site [chemical binding]; other site 1233100005078 putative aspartate binding site [chemical binding]; other site 1233100005079 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1233100005080 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1233100005081 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1233100005082 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1233100005083 dimer interface [polypeptide binding]; other site 1233100005084 active site 1233100005085 catalytic residue [active] 1233100005086 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1233100005087 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233100005088 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1233100005089 Clp protease; Region: CLP_protease; pfam00574 1233100005090 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1233100005091 active site 1233100005092 YlzJ-like protein; Region: YlzJ; pfam14035 1233100005093 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233100005094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100005095 DNA-binding site [nucleotide binding]; DNA binding site 1233100005096 UTRA domain; Region: UTRA; pfam07702 1233100005097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100005098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100005099 putative substrate translocation pore; other site 1233100005100 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1233100005101 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1233100005102 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1233100005103 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1233100005104 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1233100005105 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1233100005106 classical (c) SDRs; Region: SDR_c; cd05233 1233100005107 NAD(P) binding site [chemical binding]; other site 1233100005108 active site 1233100005109 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1233100005110 ACT domain; Region: ACT; pfam01842 1233100005111 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1233100005112 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1233100005113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100005114 non-specific DNA binding site [nucleotide binding]; other site 1233100005115 salt bridge; other site 1233100005116 sequence-specific DNA binding site [nucleotide binding]; other site 1233100005117 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1233100005118 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1233100005119 competence damage-inducible protein A; Provisional; Region: PRK00549 1233100005120 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1233100005121 putative MPT binding site; other site 1233100005122 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 1233100005123 Beta-lactamase; Region: Beta-lactamase; pfam00144 1233100005124 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1233100005125 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1233100005126 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1233100005127 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233100005128 Zn2+ binding site [ion binding]; other site 1233100005129 Mg2+ binding site [ion binding]; other site 1233100005130 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1233100005131 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1233100005132 putative active site [active] 1233100005133 metal binding site [ion binding]; metal-binding site 1233100005134 homodimer binding site [polypeptide binding]; other site 1233100005135 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1233100005136 Threonine dehydrogenase; Region: TDH; cd05281 1233100005137 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 1233100005138 structural Zn binding site [ion binding]; other site 1233100005139 catalytic Zn binding site [ion binding]; other site 1233100005140 tetramer interface [polypeptide binding]; other site 1233100005141 NADP binding site [chemical binding]; other site 1233100005142 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1233100005143 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1233100005144 substrate-cofactor binding pocket; other site 1233100005145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100005146 catalytic residue [active] 1233100005147 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1233100005148 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1233100005149 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100005150 FeS/SAM binding site; other site 1233100005151 TRAM domain; Region: TRAM; pfam01938 1233100005152 Predicted membrane protein [Function unknown]; Region: COG4550 1233100005153 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1233100005154 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1233100005155 MutS domain I; Region: MutS_I; pfam01624 1233100005156 MutS domain II; Region: MutS_II; pfam05188 1233100005157 MutS domain III; Region: MutS_III; pfam05192 1233100005158 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1233100005159 Walker A/P-loop; other site 1233100005160 ATP binding site [chemical binding]; other site 1233100005161 Q-loop/lid; other site 1233100005162 ABC transporter signature motif; other site 1233100005163 Walker B; other site 1233100005164 D-loop; other site 1233100005165 H-loop/switch region; other site 1233100005166 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1233100005167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100005168 ATP binding site [chemical binding]; other site 1233100005169 Mg2+ binding site [ion binding]; other site 1233100005170 G-X-G motif; other site 1233100005171 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1233100005172 ATP binding site [chemical binding]; other site 1233100005173 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1233100005174 Regulatory protein YrvL; Region: YrvL; pfam14184 1233100005175 transcriptional regulator BetI; Validated; Region: PRK00767 1233100005176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100005177 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1233100005178 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1233100005179 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1233100005180 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1233100005181 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1233100005182 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1233100005183 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1233100005184 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1233100005185 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1233100005186 FMN binding site [chemical binding]; other site 1233100005187 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1233100005188 substrate binding site [chemical binding]; other site 1233100005189 putative catalytic residue [active] 1233100005190 acyl carrier protein; Validated; Region: PRK07117 1233100005191 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1233100005192 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1233100005193 dimer interface [polypeptide binding]; other site 1233100005194 active site 1233100005195 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1233100005196 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1233100005197 dimer interface [polypeptide binding]; other site 1233100005198 active site 1233100005199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233100005200 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1233100005201 substrate binding site [chemical binding]; other site 1233100005202 oxyanion hole (OAH) forming residues; other site 1233100005203 trimer interface [polypeptide binding]; other site 1233100005204 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1233100005205 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233100005206 substrate binding site [chemical binding]; other site 1233100005207 oxyanion hole (OAH) forming residues; other site 1233100005208 trimer interface [polypeptide binding]; other site 1233100005209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233100005210 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1233100005211 CoA binding site [chemical binding]; other site 1233100005212 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005213 Condensation domain; Region: Condensation; pfam00668 1233100005214 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1233100005215 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1233100005216 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1233100005217 acyl-activating enzyme (AAE) consensus motif; other site 1233100005218 AMP binding site [chemical binding]; other site 1233100005219 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005220 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1233100005221 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005222 active site 1233100005223 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1233100005224 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1233100005225 KR domain; Region: KR; pfam08659 1233100005226 putative NADP binding site [chemical binding]; other site 1233100005227 active site 1233100005228 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1233100005229 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1233100005230 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005231 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1233100005232 active site 1233100005233 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1233100005234 putative NADP binding site [chemical binding]; other site 1233100005235 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1233100005236 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1233100005237 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1233100005238 active site 1233100005239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005240 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005241 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1233100005242 active site 1233100005243 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1233100005244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233100005245 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1233100005246 putative NADP binding site [chemical binding]; other site 1233100005247 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1233100005248 active site 1233100005249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005250 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005251 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1233100005252 active site 1233100005253 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1233100005254 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005255 active site 1233100005256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233100005257 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1233100005258 putative NADP binding site [chemical binding]; other site 1233100005259 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1233100005260 active site 1233100005261 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005262 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005263 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1233100005264 active site 1233100005265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005266 Condensation domain; Region: Condensation; pfam00668 1233100005267 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1233100005268 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1233100005269 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1233100005270 acyl-activating enzyme (AAE) consensus motif; other site 1233100005271 AMP binding site [chemical binding]; other site 1233100005272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005273 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1233100005274 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005275 active site 1233100005276 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1233100005277 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1233100005278 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1233100005279 putative NADP binding site [chemical binding]; other site 1233100005280 active site 1233100005281 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1233100005282 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1233100005283 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005284 active site 1233100005285 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1233100005286 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1233100005287 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1233100005288 putative NADP binding site [chemical binding]; other site 1233100005289 active site 1233100005290 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1233100005291 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1233100005292 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005293 active site 1233100005294 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1233100005295 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1233100005296 putative NADP binding site [chemical binding]; other site 1233100005297 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1233100005298 active site 1233100005299 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1233100005300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100005301 S-adenosylmethionine binding site [chemical binding]; other site 1233100005302 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1233100005303 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005304 active site 1233100005305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005306 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1233100005307 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1233100005308 active site 1233100005309 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005310 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1233100005311 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1233100005312 Cytochrome P450; Region: p450; cl12078 1233100005313 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233100005314 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1233100005315 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1233100005316 active site 1233100005317 catalytic triad [active] 1233100005318 WYL domain; Region: WYL; cl14852 1233100005319 Phage-related replication protein [General function prediction only]; Region: COG4195 1233100005320 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1233100005321 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1233100005322 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1233100005323 YmaF family; Region: YmaF; pfam12788 1233100005324 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1233100005325 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1233100005326 bacterial Hfq-like; Region: Hfq; cd01716 1233100005327 hexamer interface [polypeptide binding]; other site 1233100005328 Sm1 motif; other site 1233100005329 RNA binding site [nucleotide binding]; other site 1233100005330 Sm2 motif; other site 1233100005331 YmzC-like protein; Region: YmzC; pfam14157 1233100005332 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1233100005333 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1233100005334 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1233100005335 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1233100005336 active site 1233100005337 dimer interface [polypeptide binding]; other site 1233100005338 catalytic residues [active] 1233100005339 effector binding site; other site 1233100005340 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1233100005341 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1233100005342 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1233100005343 dimer interface [polypeptide binding]; other site 1233100005344 putative radical transfer pathway; other site 1233100005345 diiron center [ion binding]; other site 1233100005346 tyrosyl radical; other site 1233100005347 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1233100005348 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1233100005349 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1233100005350 active site 1233100005351 metal binding site [ion binding]; metal-binding site 1233100005352 Sporulation related domain; Region: SPOR; pfam05036 1233100005353 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1233100005354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100005355 Walker A motif; other site 1233100005356 ATP binding site [chemical binding]; other site 1233100005357 Walker B motif; other site 1233100005358 arginine finger; other site 1233100005359 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1233100005360 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1233100005361 HflX GTPase family; Region: HflX; cd01878 1233100005362 G1 box; other site 1233100005363 GTP/Mg2+ binding site [chemical binding]; other site 1233100005364 Switch I region; other site 1233100005365 G2 box; other site 1233100005366 G3 box; other site 1233100005367 Switch II region; other site 1233100005368 G4 box; other site 1233100005369 G5 box; other site 1233100005370 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1233100005371 Aluminium resistance protein; Region: Alum_res; pfam06838 1233100005372 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1233100005373 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1233100005374 DNA binding residues [nucleotide binding] 1233100005375 putative dimer interface [polypeptide binding]; other site 1233100005376 glutamine synthetase, type I; Region: GlnA; TIGR00653 1233100005377 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1233100005378 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1233100005379 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1233100005380 LXG domain of WXG superfamily; Region: LXG; pfam04740 1233100005381 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1233100005382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100005383 Coenzyme A binding pocket [chemical binding]; other site 1233100005384 CAAX protease self-immunity; Region: Abi; cl00558 1233100005385 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1233100005386 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1233100005387 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1233100005388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100005389 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1233100005390 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1233100005391 inhibitor binding site; inhibition site 1233100005392 active site 1233100005393 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1233100005394 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1233100005395 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1233100005396 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233100005397 nucleotide binding site [chemical binding]; other site 1233100005398 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1233100005399 xylose isomerase; Provisional; Region: PRK05474 1233100005400 xylose isomerase; Region: xylose_isom_A; TIGR02630 1233100005401 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1233100005402 N- and C-terminal domain interface [polypeptide binding]; other site 1233100005403 D-xylulose kinase; Region: XylB; TIGR01312 1233100005404 active site 1233100005405 MgATP binding site [chemical binding]; other site 1233100005406 catalytic site [active] 1233100005407 metal binding site [ion binding]; metal-binding site 1233100005408 xylulose binding site [chemical binding]; other site 1233100005409 homodimer interface [polypeptide binding]; other site 1233100005410 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1233100005411 Staphylococcal nuclease homologues; Region: SNc; smart00318 1233100005412 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1233100005413 Catalytic site; other site 1233100005414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100005415 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1233100005416 putative substrate translocation pore; other site 1233100005417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100005418 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1233100005419 alanine racemase; Region: alr; TIGR00492 1233100005420 active site 1233100005421 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1233100005422 dimer interface [polypeptide binding]; other site 1233100005423 substrate binding site [chemical binding]; other site 1233100005424 catalytic residues [active] 1233100005425 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1233100005426 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1233100005427 trimer interface [polypeptide binding]; other site 1233100005428 active site 1233100005429 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1233100005430 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1233100005431 dimerization interface [polypeptide binding]; other site 1233100005432 active site 1233100005433 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1233100005434 putative binding site; other site 1233100005435 putative dimer interface [polypeptide binding]; other site 1233100005436 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1233100005437 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1233100005438 putative hydrophobic ligand binding site [chemical binding]; other site 1233100005439 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233100005440 Spore germination protein; Region: Spore_permease; pfam03845 1233100005441 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1233100005442 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1233100005443 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1233100005444 YndJ-like protein; Region: YndJ; pfam14158 1233100005445 Phage-related replication protein [General function prediction only]; Region: COG4195 1233100005446 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1233100005447 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1233100005448 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1233100005449 putative active site [active] 1233100005450 putative Mg binding site [ion binding]; other site 1233100005451 LexA repressor; Validated; Region: PRK00215 1233100005452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100005453 putative DNA binding site [nucleotide binding]; other site 1233100005454 putative Zn2+ binding site [ion binding]; other site 1233100005455 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1233100005456 Catalytic site [active] 1233100005457 cell division suppressor protein YneA; Provisional; Region: PRK14125 1233100005458 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100005459 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1233100005460 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1233100005461 catalytic residues [active] 1233100005462 catalytic nucleophile [active] 1233100005463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1233100005464 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1233100005465 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1233100005466 TPP-binding site [chemical binding]; other site 1233100005467 dimer interface [polypeptide binding]; other site 1233100005468 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1233100005469 PYR/PP interface [polypeptide binding]; other site 1233100005470 dimer interface [polypeptide binding]; other site 1233100005471 TPP binding site [chemical binding]; other site 1233100005472 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233100005473 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1233100005474 hypothetical protein; Provisional; Region: PRK01844 1233100005475 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1233100005476 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1233100005477 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1233100005478 Response regulator receiver domain; Region: Response_reg; pfam00072 1233100005479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100005480 active site 1233100005481 phosphorylation site [posttranslational modification] 1233100005482 intermolecular recognition site; other site 1233100005483 dimerization interface [polypeptide binding]; other site 1233100005484 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1233100005485 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1233100005486 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1233100005487 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1233100005488 putative dimer interface [polypeptide binding]; other site 1233100005489 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1233100005490 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1233100005491 aconitate hydratase; Validated; Region: PRK09277 1233100005492 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1233100005493 substrate binding site [chemical binding]; other site 1233100005494 ligand binding site [chemical binding]; other site 1233100005495 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1233100005496 substrate binding site [chemical binding]; other site 1233100005497 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1233100005498 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1233100005499 catalytic residues [active] 1233100005500 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1233100005501 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1233100005502 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1233100005503 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1233100005504 active site 1233100005505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1233100005506 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1233100005507 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1233100005508 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1233100005509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100005510 ATP binding site [chemical binding]; other site 1233100005511 Mg2+ binding site [ion binding]; other site 1233100005512 G-X-G motif; other site 1233100005513 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1233100005514 anchoring element; other site 1233100005515 dimer interface [polypeptide binding]; other site 1233100005516 ATP binding site [chemical binding]; other site 1233100005517 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1233100005518 active site 1233100005519 putative metal-binding site [ion binding]; other site 1233100005520 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1233100005521 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1233100005522 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1233100005523 CAP-like domain; other site 1233100005524 active site 1233100005525 primary dimer interface [polypeptide binding]; other site 1233100005526 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100005527 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100005528 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100005529 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1233100005530 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1233100005531 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1233100005532 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1233100005533 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1233100005534 Cellulose binding domain; Region: CBM_3; pfam00942 1233100005535 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1233100005536 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1233100005537 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1233100005538 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1233100005539 substrate binding site [chemical binding]; other site 1233100005540 active site 1233100005541 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1233100005542 metal binding site [ion binding]; metal-binding site 1233100005543 ligand binding site [chemical binding]; other site 1233100005544 Predicted membrane protein [Function unknown]; Region: COG2246 1233100005545 GtrA-like protein; Region: GtrA; pfam04138 1233100005546 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1233100005547 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1233100005548 active site 1233100005549 tetramer interface; other site 1233100005550 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1233100005551 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233100005552 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1233100005553 DHH family; Region: DHH; pfam01368 1233100005554 DHHA1 domain; Region: DHHA1; pfam02272 1233100005555 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1233100005556 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1233100005557 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1233100005558 enoyl-CoA hydratase; Provisional; Region: PRK07657 1233100005559 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233100005560 substrate binding site [chemical binding]; other site 1233100005561 oxyanion hole (OAH) forming residues; other site 1233100005562 trimer interface [polypeptide binding]; other site 1233100005563 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1233100005564 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1233100005565 active site 1233100005566 catalytic residues [active] 1233100005567 metal binding site [ion binding]; metal-binding site 1233100005568 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1233100005569 carboxyltransferase (CT) interaction site; other site 1233100005570 biotinylation site [posttranslational modification]; other site 1233100005571 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1233100005572 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233100005573 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1233100005574 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1233100005575 AMP-binding domain protein; Validated; Region: PRK08315 1233100005576 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1233100005577 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1233100005578 acyl-activating enzyme (AAE) consensus motif; other site 1233100005579 putative AMP binding site [chemical binding]; other site 1233100005580 putative active site [active] 1233100005581 putative CoA binding site [chemical binding]; other site 1233100005582 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233100005583 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233100005584 active site 1233100005585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1233100005586 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1233100005587 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1233100005588 Condensation domain; Region: Condensation; pfam00668 1233100005589 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1233100005590 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1233100005591 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1233100005592 acyl-activating enzyme (AAE) consensus motif; other site 1233100005593 AMP binding site [chemical binding]; other site 1233100005594 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005595 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1233100005596 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1233100005597 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1233100005598 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1233100005599 acyl-activating enzyme (AAE) consensus motif; other site 1233100005600 AMP binding site [chemical binding]; other site 1233100005601 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005602 Condensation domain; Region: Condensation; pfam00668 1233100005603 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1233100005604 Condensation domain; Region: Condensation; pfam00668 1233100005605 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1233100005606 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1233100005607 acyl-activating enzyme (AAE) consensus motif; other site 1233100005608 AMP binding site [chemical binding]; other site 1233100005609 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005610 Condensation domain; Region: Condensation; pfam00668 1233100005611 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1233100005612 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1233100005613 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1233100005614 acyl-activating enzyme (AAE) consensus motif; other site 1233100005615 AMP binding site [chemical binding]; other site 1233100005616 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005617 Condensation domain; Region: Condensation; pfam00668 1233100005618 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1233100005619 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1233100005620 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1233100005621 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1233100005622 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1233100005623 acyl-activating enzyme (AAE) consensus motif; other site 1233100005624 AMP binding site [chemical binding]; other site 1233100005625 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100005626 Condensation domain; Region: Condensation; pfam00668 1233100005627 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1233100005628 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1233100005629 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1233100005630 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1233100005631 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1233100005632 active site 1233100005633 catalytic residues [active] 1233100005634 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1233100005635 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1233100005636 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1233100005637 Int/Topo IB signature motif; other site 1233100005638 Helix-turn-helix domain; Region: HTH_17; cl17695 1233100005639 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1233100005640 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1233100005641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100005642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100005643 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1233100005644 putative dimerization interface [polypeptide binding]; other site 1233100005645 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1233100005646 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1233100005647 NAD(P) binding site [chemical binding]; other site 1233100005648 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1233100005649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1233100005650 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1233100005651 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1233100005652 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1233100005653 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1233100005654 active site 1233100005655 FMN binding site [chemical binding]; other site 1233100005656 substrate binding site [chemical binding]; other site 1233100005657 3Fe-4S cluster binding site [ion binding]; other site 1233100005658 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1233100005659 domain interface; other site 1233100005660 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1233100005661 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1233100005662 active site 1233100005663 dimer interface [polypeptide binding]; other site 1233100005664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100005665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100005666 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1233100005667 putative dimerization interface [polypeptide binding]; other site 1233100005668 gamma-glutamyl kinase; Provisional; Region: PRK13402 1233100005669 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1233100005670 nucleotide binding site [chemical binding]; other site 1233100005671 homotetrameric interface [polypeptide binding]; other site 1233100005672 putative phosphate binding site [ion binding]; other site 1233100005673 putative allosteric binding site; other site 1233100005674 PUA domain; Region: PUA; pfam01472 1233100005675 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1233100005676 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1233100005677 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1233100005678 classical (c) SDRs; Region: SDR_c; cd05233 1233100005679 NAD(P) binding site [chemical binding]; other site 1233100005680 active site 1233100005681 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1233100005682 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1233100005683 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1233100005684 polyol permease family; Region: 2A0118; TIGR00897 1233100005685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100005686 putative substrate translocation pore; other site 1233100005687 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1233100005688 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1233100005689 putative N- and C-terminal domain interface [polypeptide binding]; other site 1233100005690 putative active site [active] 1233100005691 putative MgATP binding site [chemical binding]; other site 1233100005692 catalytic site [active] 1233100005693 metal binding site [ion binding]; metal-binding site 1233100005694 carbohydrate binding site [chemical binding]; other site 1233100005695 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1233100005696 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1233100005697 putative ligand binding site [chemical binding]; other site 1233100005698 putative NAD binding site [chemical binding]; other site 1233100005699 catalytic site [active] 1233100005700 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1233100005701 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1233100005702 putative [4Fe-4S] binding site [ion binding]; other site 1233100005703 putative molybdopterin cofactor binding site [chemical binding]; other site 1233100005704 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1233100005705 putative molybdopterin cofactor binding site; other site 1233100005706 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1233100005707 CHASE3 domain; Region: CHASE3; cl05000 1233100005708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100005709 dimerization interface [polypeptide binding]; other site 1233100005710 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233100005711 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100005712 dimer interface [polypeptide binding]; other site 1233100005713 putative CheW interface [polypeptide binding]; other site 1233100005714 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1233100005715 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1233100005716 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1233100005717 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1233100005718 Predicted membrane protein [Function unknown]; Region: COG3619 1233100005719 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1233100005720 Amb_all domain; Region: Amb_all; smart00656 1233100005721 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1233100005722 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1233100005723 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1233100005724 Cupin; Region: Cupin_1; smart00835 1233100005725 Cupin; Region: Cupin_1; smart00835 1233100005726 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1233100005727 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1233100005728 VanW like protein; Region: VanW; pfam04294 1233100005729 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1233100005730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100005731 salt bridge; other site 1233100005732 non-specific DNA binding site [nucleotide binding]; other site 1233100005733 sequence-specific DNA binding site [nucleotide binding]; other site 1233100005734 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1233100005735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100005736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100005737 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233100005738 dimerization interface [polypeptide binding]; other site 1233100005739 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1233100005740 EamA-like transporter family; Region: EamA; pfam00892 1233100005741 EamA-like transporter family; Region: EamA; pfam00892 1233100005742 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1233100005743 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1233100005744 conserved cys residue [active] 1233100005745 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1233100005746 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1233100005747 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1233100005748 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1233100005749 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1233100005750 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1233100005751 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1233100005752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1233100005753 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1233100005754 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1233100005755 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1233100005756 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1233100005757 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1233100005758 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1233100005759 dimer interface [polypeptide binding]; other site 1233100005760 putative tRNA-binding site [nucleotide binding]; other site 1233100005761 Cupin domain; Region: Cupin_2; pfam07883 1233100005762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233100005763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100005764 WHG domain; Region: WHG; pfam13305 1233100005765 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233100005766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1233100005767 Predicted transcriptional regulator [Transcription]; Region: COG2378 1233100005768 HTH domain; Region: HTH_11; pfam08279 1233100005769 WYL domain; Region: WYL; pfam13280 1233100005770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100005771 dimerization interface [polypeptide binding]; other site 1233100005772 putative DNA binding site [nucleotide binding]; other site 1233100005773 putative Zn2+ binding site [ion binding]; other site 1233100005774 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1233100005775 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1233100005776 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1233100005777 catalytic residue [active] 1233100005778 Predicted membrane protein [Function unknown]; Region: COG2322 1233100005779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1233100005780 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1233100005781 putative dimer interface [polypeptide binding]; other site 1233100005782 catalytic triad [active] 1233100005783 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1233100005784 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1233100005785 putative di-iron ligands [ion binding]; other site 1233100005786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1233100005787 Histidine kinase; Region: HisKA_3; pfam07730 1233100005788 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1233100005789 ATP binding site [chemical binding]; other site 1233100005790 Mg2+ binding site [ion binding]; other site 1233100005791 G-X-G motif; other site 1233100005792 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233100005793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100005794 active site 1233100005795 phosphorylation site [posttranslational modification] 1233100005796 intermolecular recognition site; other site 1233100005797 dimerization interface [polypeptide binding]; other site 1233100005798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233100005799 DNA binding residues [nucleotide binding] 1233100005800 dimerization interface [polypeptide binding]; other site 1233100005801 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100005802 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100005803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1233100005804 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1233100005805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100005806 ATP binding site [chemical binding]; other site 1233100005807 putative Mg++ binding site [ion binding]; other site 1233100005808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100005809 nucleotide binding region [chemical binding]; other site 1233100005810 ATP-binding site [chemical binding]; other site 1233100005811 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1233100005812 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1233100005813 azoreductase; Provisional; Region: PRK13556 1233100005814 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1233100005815 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1233100005816 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1233100005817 putative dimer interface [polypeptide binding]; other site 1233100005818 Pleckstrin homology-like domain; Region: PH-like; cl17171 1233100005819 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1233100005820 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233100005821 NAD(P) binding site [chemical binding]; other site 1233100005822 catalytic residues [active] 1233100005823 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1233100005824 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1233100005825 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1233100005826 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1233100005827 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1233100005828 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1233100005829 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1233100005830 Na2 binding site [ion binding]; other site 1233100005831 putative substrate binding site 1 [chemical binding]; other site 1233100005832 Na binding site 1 [ion binding]; other site 1233100005833 putative substrate binding site 2 [chemical binding]; other site 1233100005834 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1233100005835 Sodium Bile acid symporter family; Region: SBF; pfam01758 1233100005836 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1233100005837 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1233100005838 E3 interaction surface; other site 1233100005839 lipoyl attachment site [posttranslational modification]; other site 1233100005840 e3 binding domain; Region: E3_binding; pfam02817 1233100005841 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1233100005842 2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239 1233100005843 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1233100005844 TPP-binding site [chemical binding]; other site 1233100005845 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1233100005846 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1233100005847 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1233100005848 metal ion-dependent adhesion site (MIDAS); other site 1233100005849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100005850 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1233100005851 Walker A motif; other site 1233100005852 ATP binding site [chemical binding]; other site 1233100005853 Walker B motif; other site 1233100005854 arginine finger; other site 1233100005855 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1233100005856 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1233100005857 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1233100005858 E-class dimer interface [polypeptide binding]; other site 1233100005859 P-class dimer interface [polypeptide binding]; other site 1233100005860 active site 1233100005861 Cu2+ binding site [ion binding]; other site 1233100005862 Zn2+ binding site [ion binding]; other site 1233100005863 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100005864 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100005865 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100005866 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233100005867 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233100005868 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1233100005869 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1233100005870 active site 1233100005871 TDP-binding site; other site 1233100005872 acceptor substrate-binding pocket; other site 1233100005873 multidrug efflux protein; Reviewed; Region: PRK01766 1233100005874 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1233100005875 cation binding site [ion binding]; other site 1233100005876 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1233100005877 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1233100005878 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1233100005879 rarD protein; Region: rarD; TIGR00688 1233100005880 EamA-like transporter family; Region: EamA; pfam00892 1233100005881 GntP family permease; Region: GntP_permease; pfam02447 1233100005882 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1233100005883 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1233100005884 Predicted transcriptional regulators [Transcription]; Region: COG1733 1233100005885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100005886 dimerization interface [polypeptide binding]; other site 1233100005887 putative DNA binding site [nucleotide binding]; other site 1233100005888 putative Zn2+ binding site [ion binding]; other site 1233100005889 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1233100005890 dimer interface [polypeptide binding]; other site 1233100005891 FMN binding site [chemical binding]; other site 1233100005892 Predicted esterase [General function prediction only]; Region: COG0400 1233100005893 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1233100005894 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100005895 Zn binding site [ion binding]; other site 1233100005896 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1233100005897 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100005898 Zn binding site [ion binding]; other site 1233100005899 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1233100005900 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1233100005901 Na binding site [ion binding]; other site 1233100005902 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1233100005903 C-terminal peptidase (prc); Region: prc; TIGR00225 1233100005904 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1233100005905 protein binding site [polypeptide binding]; other site 1233100005906 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1233100005907 Catalytic dyad [active] 1233100005908 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233100005909 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1233100005910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100005911 S-adenosylmethionine binding site [chemical binding]; other site 1233100005912 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1233100005913 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1233100005914 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1233100005915 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1233100005916 YodL-like; Region: YodL; pfam14191 1233100005917 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1233100005918 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1233100005919 active site 1233100005920 YozD-like protein; Region: YozD; pfam14162 1233100005921 hypothetical protein; Provisional; Region: PRK13672 1233100005922 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1233100005923 toxin interface [polypeptide binding]; other site 1233100005924 Zn binding site [ion binding]; other site 1233100005925 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1233100005926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100005927 FeS/SAM binding site; other site 1233100005928 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1233100005929 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1233100005930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100005931 Coenzyme A binding pocket [chemical binding]; other site 1233100005932 acetylornithine deacetylase; Validated; Region: PRK06915 1233100005933 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1233100005934 metal binding site [ion binding]; metal-binding site 1233100005935 dimer interface [polypeptide binding]; other site 1233100005936 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1233100005937 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1233100005938 hypothetical protein; Provisional; Region: PRK06917 1233100005939 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233100005940 inhibitor-cofactor binding pocket; inhibition site 1233100005941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100005942 catalytic residue [active] 1233100005943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100005944 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1233100005945 Coenzyme A binding pocket [chemical binding]; other site 1233100005946 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1233100005947 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100005948 active site 1233100005949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1233100005950 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1233100005951 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1233100005952 Phytase; Region: Phytase; cl17685 1233100005953 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1233100005954 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1233100005955 NAD(P) binding site [chemical binding]; other site 1233100005956 homodimer interface [polypeptide binding]; other site 1233100005957 substrate binding site [chemical binding]; other site 1233100005958 active site 1233100005959 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1233100005960 SelR domain; Region: SelR; pfam01641 1233100005961 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1233100005962 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100005963 MarR family; Region: MarR; pfam01047 1233100005964 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1233100005965 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1233100005966 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1233100005967 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1233100005968 active site 1233100005969 catalytic triad [active] 1233100005970 oxyanion hole [active] 1233100005971 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1233100005972 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1233100005973 Cu(I) binding site [ion binding]; other site 1233100005974 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1233100005975 threonine dehydratase; Validated; Region: PRK08639 1233100005976 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1233100005977 tetramer interface [polypeptide binding]; other site 1233100005978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100005979 catalytic residue [active] 1233100005980 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1233100005981 putative Ile/Val binding site [chemical binding]; other site 1233100005982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100005983 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1233100005984 Walker A motif; other site 1233100005985 ATP binding site [chemical binding]; other site 1233100005986 Walker B motif; other site 1233100005987 arginine finger; other site 1233100005988 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1233100005989 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1233100005990 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1233100005991 folate binding site [chemical binding]; other site 1233100005992 NADP+ binding site [chemical binding]; other site 1233100005993 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1233100005994 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1233100005995 dimerization interface [polypeptide binding]; other site 1233100005996 active site 1233100005997 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1233100005998 tetramer interfaces [polypeptide binding]; other site 1233100005999 binuclear metal-binding site [ion binding]; other site 1233100006000 YpjP-like protein; Region: YpjP; pfam14005 1233100006001 ribosomal biogenesis protein; Validated; Region: PRK00933 1233100006002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100006003 S-adenosylmethionine binding site [chemical binding]; other site 1233100006004 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1233100006005 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1233100006006 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1233100006007 Virulence factor; Region: Virulence_fact; pfam13769 1233100006008 HEAT repeats; Region: HEAT_2; pfam13646 1233100006009 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1233100006010 HEAT repeats; Region: HEAT_2; pfam13646 1233100006011 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1233100006012 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1233100006013 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233100006014 Zn2+ binding site [ion binding]; other site 1233100006015 Mg2+ binding site [ion binding]; other site 1233100006016 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1233100006017 catalytic residues [active] 1233100006018 dimer interface [polypeptide binding]; other site 1233100006019 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1233100006020 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1233100006021 proposed active site lysine [active] 1233100006022 conserved cys residue [active] 1233100006023 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1233100006024 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1233100006025 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1233100006026 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1233100006027 DNA-binding site [nucleotide binding]; DNA binding site 1233100006028 RNA-binding motif; other site 1233100006029 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1233100006030 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1233100006031 hypothetical protein; Validated; Region: PRK07708 1233100006032 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1233100006033 RNA/DNA hybrid binding site [nucleotide binding]; other site 1233100006034 active site 1233100006035 conserved hypothetical integral membrane protein; Region: TIGR00697 1233100006036 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1233100006037 RNA/DNA hybrid binding site [nucleotide binding]; other site 1233100006038 active site 1233100006039 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1233100006040 5'-3' exonuclease; Region: 53EXOc; smart00475 1233100006041 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1233100006042 active site 1233100006043 metal binding site 1 [ion binding]; metal-binding site 1233100006044 putative 5' ssDNA interaction site; other site 1233100006045 metal binding site 3; metal-binding site 1233100006046 metal binding site 2 [ion binding]; metal-binding site 1233100006047 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1233100006048 putative DNA binding site [nucleotide binding]; other site 1233100006049 putative metal binding site [ion binding]; other site 1233100006050 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1233100006051 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1233100006052 Dynamin family; Region: Dynamin_N; pfam00350 1233100006053 G1 box; other site 1233100006054 GTP/Mg2+ binding site [chemical binding]; other site 1233100006055 G2 box; other site 1233100006056 Switch I region; other site 1233100006057 G3 box; other site 1233100006058 Switch II region; other site 1233100006059 G4 box; other site 1233100006060 G5 box; other site 1233100006061 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1233100006062 G1 box; other site 1233100006063 GTP/Mg2+ binding site [chemical binding]; other site 1233100006064 Dynamin family; Region: Dynamin_N; pfam00350 1233100006065 G2 box; other site 1233100006066 Switch I region; other site 1233100006067 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1233100006068 G3 box; other site 1233100006069 Switch II region; other site 1233100006070 GTP/Mg2+ binding site [chemical binding]; other site 1233100006071 G4 box; other site 1233100006072 G5 box; other site 1233100006073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1233100006074 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1233100006075 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1233100006076 malonyl-CoA binding site [chemical binding]; other site 1233100006077 dimer interface [polypeptide binding]; other site 1233100006078 active site 1233100006079 product binding site; other site 1233100006080 xanthine permease; Region: pbuX; TIGR03173 1233100006081 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1233100006082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100006083 active site 1233100006084 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1233100006085 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1233100006086 active site 1233100006087 Zn binding site [ion binding]; other site 1233100006088 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1233100006089 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1233100006090 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1233100006091 active site 1233100006092 intersubunit interface [polypeptide binding]; other site 1233100006093 catalytic residue [active] 1233100006094 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1233100006095 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1233100006096 substrate binding site [chemical binding]; other site 1233100006097 ATP binding site [chemical binding]; other site 1233100006098 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100006099 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100006100 DNA binding site [nucleotide binding] 1233100006101 domain linker motif; other site 1233100006102 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1233100006103 putative dimerization interface [polypeptide binding]; other site 1233100006104 putative ligand binding site [chemical binding]; other site 1233100006105 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1233100006106 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1233100006107 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1233100006108 NADP binding site [chemical binding]; other site 1233100006109 homodimer interface [polypeptide binding]; other site 1233100006110 active site 1233100006111 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1233100006112 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1233100006113 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1233100006114 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1233100006115 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1233100006116 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1233100006117 cell division protein GpsB; Provisional; Region: PRK14127 1233100006118 DivIVA domain; Region: DivI1A_domain; TIGR03544 1233100006119 hypothetical protein; Provisional; Region: PRK13660 1233100006120 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1233100006121 RNase_H superfamily; Region: RNase_H_2; pfam13482 1233100006122 active site 1233100006123 substrate binding site [chemical binding]; other site 1233100006124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1233100006125 binding surface 1233100006126 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1233100006127 TPR motif; other site 1233100006128 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1233100006129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100006130 ATP binding site [chemical binding]; other site 1233100006131 putative Mg++ binding site [ion binding]; other site 1233100006132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100006133 nucleotide binding region [chemical binding]; other site 1233100006134 ATP-binding site [chemical binding]; other site 1233100006135 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1233100006136 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1233100006137 HPr interaction site; other site 1233100006138 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1233100006139 active site 1233100006140 phosphorylation site [posttranslational modification] 1233100006141 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1233100006142 YppG-like protein; Region: YppG; pfam14179 1233100006143 YppF-like protein; Region: YppF; pfam14178 1233100006144 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1233100006145 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1233100006146 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1233100006147 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1233100006148 Transglycosylase; Region: Transgly; pfam00912 1233100006149 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233100006150 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1233100006151 Interdomain contacts; other site 1233100006152 Cytokine receptor motif; other site 1233100006153 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1233100006154 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1233100006155 minor groove reading motif; other site 1233100006156 helix-hairpin-helix signature motif; other site 1233100006157 substrate binding pocket [chemical binding]; other site 1233100006158 active site 1233100006159 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1233100006160 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1233100006161 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1233100006162 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1233100006163 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1233100006164 putative dimer interface [polypeptide binding]; other site 1233100006165 putative anticodon binding site; other site 1233100006166 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1233100006167 homodimer interface [polypeptide binding]; other site 1233100006168 motif 1; other site 1233100006169 motif 2; other site 1233100006170 active site 1233100006171 motif 3; other site 1233100006172 aspartate aminotransferase; Provisional; Region: PRK05764 1233100006173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100006174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100006175 homodimer interface [polypeptide binding]; other site 1233100006176 catalytic residue [active] 1233100006177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1233100006178 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1233100006179 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1233100006180 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1233100006181 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1233100006182 active site 1233100006183 catalytic site [active] 1233100006184 substrate binding site [chemical binding]; other site 1233100006185 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1233100006186 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1233100006187 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1233100006188 active site 1233100006189 tetramerization interface [polypeptide binding]; other site 1233100006190 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1233100006191 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1233100006192 active site 1233100006193 ATP-binding site [chemical binding]; other site 1233100006194 pantoate-binding site; other site 1233100006195 HXXH motif; other site 1233100006196 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1233100006197 oligomerization interface [polypeptide binding]; other site 1233100006198 active site 1233100006199 metal binding site [ion binding]; metal-binding site 1233100006200 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1233100006201 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1233100006202 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1233100006203 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1233100006204 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1233100006205 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1233100006206 active site 1233100006207 NTP binding site [chemical binding]; other site 1233100006208 metal binding triad [ion binding]; metal-binding site 1233100006209 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1233100006210 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1233100006211 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1233100006212 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1233100006213 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1233100006214 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1233100006215 active site 1233100006216 dimer interfaces [polypeptide binding]; other site 1233100006217 catalytic residues [active] 1233100006218 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1233100006219 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1233100006220 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1233100006221 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1233100006222 homodimer interface [polypeptide binding]; other site 1233100006223 metal binding site [ion binding]; metal-binding site 1233100006224 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233100006225 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100006226 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100006227 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233100006228 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1233100006229 Predicted membrane protein [Function unknown]; Region: COG4347 1233100006230 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1233100006231 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1233100006232 intrachain domain interface; other site 1233100006233 Qi binding site; other site 1233100006234 Qo binding site; other site 1233100006235 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1233100006236 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1233100006237 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1233100006238 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1233100006239 interchain domain interface [polypeptide binding]; other site 1233100006240 intrachain domain interface; other site 1233100006241 heme bH binding site [chemical binding]; other site 1233100006242 Qi binding site; other site 1233100006243 heme bL binding site [chemical binding]; other site 1233100006244 Qo binding site; other site 1233100006245 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1233100006246 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1233100006247 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1233100006248 iron-sulfur cluster [ion binding]; other site 1233100006249 [2Fe-2S] cluster binding site [ion binding]; other site 1233100006250 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1233100006251 hypothetical protein; Provisional; Region: PRK03636 1233100006252 UPF0302 domain; Region: UPF0302; pfam08864 1233100006253 IDEAL domain; Region: IDEAL; pfam08858 1233100006254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100006255 TPR motif; other site 1233100006256 binding surface 1233100006257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100006258 binding surface 1233100006259 TPR motif; other site 1233100006260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100006261 TPR motif; other site 1233100006262 binding surface 1233100006263 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1233100006264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100006265 binding surface 1233100006266 TPR motif; other site 1233100006267 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1233100006268 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1233100006269 hinge; other site 1233100006270 active site 1233100006271 prephenate dehydrogenase; Validated; Region: PRK06545 1233100006272 prephenate dehydrogenase; Validated; Region: PRK08507 1233100006273 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1233100006274 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1233100006275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100006276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100006277 homodimer interface [polypeptide binding]; other site 1233100006278 catalytic residue [active] 1233100006279 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1233100006280 substrate binding site [chemical binding]; other site 1233100006281 active site 1233100006282 catalytic residues [active] 1233100006283 heterodimer interface [polypeptide binding]; other site 1233100006284 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1233100006285 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1233100006286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100006287 catalytic residue [active] 1233100006288 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1233100006289 active site 1233100006290 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1233100006291 active site 1233100006292 ribulose/triose binding site [chemical binding]; other site 1233100006293 phosphate binding site [ion binding]; other site 1233100006294 substrate (anthranilate) binding pocket [chemical binding]; other site 1233100006295 product (indole) binding pocket [chemical binding]; other site 1233100006296 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1233100006297 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1233100006298 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1233100006299 anthranilate synthase component I; Provisional; Region: PRK13569 1233100006300 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1233100006301 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1233100006302 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1233100006303 homotrimer interaction site [polypeptide binding]; other site 1233100006304 active site 1233100006305 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1233100006306 active site 1233100006307 dimer interface [polypeptide binding]; other site 1233100006308 metal binding site [ion binding]; metal-binding site 1233100006309 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1233100006310 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1233100006311 Tetramer interface [polypeptide binding]; other site 1233100006312 active site 1233100006313 FMN-binding site [chemical binding]; other site 1233100006314 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1233100006315 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1233100006316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100006317 S-adenosylmethionine binding site [chemical binding]; other site 1233100006318 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1233100006319 active site 1233100006320 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1233100006321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100006322 S-adenosylmethionine binding site [chemical binding]; other site 1233100006323 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1233100006324 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1233100006325 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1233100006326 homodecamer interface [polypeptide binding]; other site 1233100006327 GTP cyclohydrolase I; Provisional; Region: PLN03044 1233100006328 active site 1233100006329 putative catalytic site residues [active] 1233100006330 zinc binding site [ion binding]; other site 1233100006331 GTP-CH-I/GFRP interaction surface; other site 1233100006332 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1233100006333 IHF dimer interface [polypeptide binding]; other site 1233100006334 IHF - DNA interface [nucleotide binding]; other site 1233100006335 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1233100006336 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1233100006337 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1233100006338 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1233100006339 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1233100006340 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1233100006341 GTP-binding protein Der; Reviewed; Region: PRK00093 1233100006342 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1233100006343 G1 box; other site 1233100006344 GTP/Mg2+ binding site [chemical binding]; other site 1233100006345 Switch I region; other site 1233100006346 G2 box; other site 1233100006347 Switch II region; other site 1233100006348 G3 box; other site 1233100006349 G4 box; other site 1233100006350 G5 box; other site 1233100006351 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1233100006352 G1 box; other site 1233100006353 GTP/Mg2+ binding site [chemical binding]; other site 1233100006354 Switch I region; other site 1233100006355 G2 box; other site 1233100006356 G3 box; other site 1233100006357 Switch II region; other site 1233100006358 G4 box; other site 1233100006359 G5 box; other site 1233100006360 YIEGIA protein; Region: YIEGIA; pfam14045 1233100006361 YpzI-like protein; Region: YpzI; pfam14140 1233100006362 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1233100006363 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1233100006364 homotetramer interface [polypeptide binding]; other site 1233100006365 FMN binding site [chemical binding]; other site 1233100006366 homodimer contacts [polypeptide binding]; other site 1233100006367 putative active site [active] 1233100006368 putative substrate binding site [chemical binding]; other site 1233100006369 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1233100006370 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1233100006371 RNA binding site [nucleotide binding]; other site 1233100006372 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1233100006373 RNA binding site [nucleotide binding]; other site 1233100006374 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1233100006375 RNA binding site [nucleotide binding]; other site 1233100006376 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1233100006377 RNA binding site [nucleotide binding]; other site 1233100006378 cytidylate kinase; Provisional; Region: cmk; PRK00023 1233100006379 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1233100006380 CMP-binding site; other site 1233100006381 The sites determining sugar specificity; other site 1233100006382 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1233100006383 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1233100006384 PilZ domain; Region: PilZ; pfam07238 1233100006385 germination protein YpeB; Region: spore_YpeB; TIGR02889 1233100006386 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233100006387 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1233100006388 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1233100006389 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1233100006390 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1233100006391 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1233100006392 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1233100006393 NAD(P) binding site [chemical binding]; other site 1233100006394 adaptor protein; Provisional; Region: PRK02899 1233100006395 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1233100006396 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1233100006397 putative active site [active] 1233100006398 putative metal binding site [ion binding]; other site 1233100006399 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1233100006400 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100006401 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1233100006402 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100006403 ATP binding site [chemical binding]; other site 1233100006404 putative Mg++ binding site [ion binding]; other site 1233100006405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100006406 nucleotide binding region [chemical binding]; other site 1233100006407 ATP-binding site [chemical binding]; other site 1233100006408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1233100006409 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1233100006410 Predicted membrane protein [Function unknown]; Region: COG3601 1233100006411 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1233100006412 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1233100006413 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1233100006414 ligand binding site [chemical binding]; other site 1233100006415 NAD binding site [chemical binding]; other site 1233100006416 dimerization interface [polypeptide binding]; other site 1233100006417 catalytic site [active] 1233100006418 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1233100006419 putative L-serine binding site [chemical binding]; other site 1233100006420 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1233100006421 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1233100006422 active site 1233100006423 catalytic residue [active] 1233100006424 dimer interface [polypeptide binding]; other site 1233100006425 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1233100006426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100006427 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100006428 DNA binding residues [nucleotide binding] 1233100006429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1233100006430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100006431 dimerization interface [polypeptide binding]; other site 1233100006432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100006433 putative active site [active] 1233100006434 heme pocket [chemical binding]; other site 1233100006435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100006436 dimer interface [polypeptide binding]; other site 1233100006437 phosphorylation site [posttranslational modification] 1233100006438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100006439 ATP binding site [chemical binding]; other site 1233100006440 Mg2+ binding site [ion binding]; other site 1233100006441 G-X-G motif; other site 1233100006442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100006443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100006444 active site 1233100006445 phosphorylation site [posttranslational modification] 1233100006446 intermolecular recognition site; other site 1233100006447 dimerization interface [polypeptide binding]; other site 1233100006448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100006449 DNA binding site [nucleotide binding] 1233100006450 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1233100006451 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1233100006452 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1233100006453 ResB-like family; Region: ResB; pfam05140 1233100006454 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1233100006455 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233100006456 catalytic residues [active] 1233100006457 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1233100006458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233100006459 RNA binding surface [nucleotide binding]; other site 1233100006460 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1233100006461 active site 1233100006462 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1233100006463 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1233100006464 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1233100006465 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1233100006466 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1233100006467 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1233100006468 segregation and condensation protein B; Region: TIGR00281 1233100006469 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1233100006470 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1233100006471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100006472 Coenzyme A binding pocket [chemical binding]; other site 1233100006473 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1233100006474 homopentamer interface [polypeptide binding]; other site 1233100006475 active site 1233100006476 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1233100006477 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1233100006478 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1233100006479 dimerization interface [polypeptide binding]; other site 1233100006480 active site 1233100006481 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1233100006482 Lumazine binding domain; Region: Lum_binding; pfam00677 1233100006483 Lumazine binding domain; Region: Lum_binding; pfam00677 1233100006484 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1233100006485 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1233100006486 catalytic motif [active] 1233100006487 Zn binding site [ion binding]; other site 1233100006488 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1233100006489 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1233100006490 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1233100006491 Catalytic site [active] 1233100006492 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233100006493 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1233100006494 active site 1233100006495 Predicted secreted protein [Function unknown]; Region: COG4086 1233100006496 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1233100006497 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1233100006498 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1233100006499 active site 1233100006500 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1233100006501 substrate binding site [chemical binding]; other site 1233100006502 catalytic residues [active] 1233100006503 dimer interface [polypeptide binding]; other site 1233100006504 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233100006505 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1233100006506 stage V sporulation protein AD; Validated; Region: PRK08304 1233100006507 stage V sporulation protein AD; Provisional; Region: PRK12404 1233100006508 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1233100006509 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1233100006510 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1233100006511 sporulation sigma factor SigF; Validated; Region: PRK05572 1233100006512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100006513 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233100006514 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100006515 DNA binding residues [nucleotide binding] 1233100006516 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1233100006517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100006518 ATP binding site [chemical binding]; other site 1233100006519 Mg2+ binding site [ion binding]; other site 1233100006520 G-X-G motif; other site 1233100006521 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1233100006522 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1233100006523 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1233100006524 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1233100006525 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1233100006526 phosphopentomutase; Provisional; Region: PRK05362 1233100006527 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1233100006528 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1233100006529 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1233100006530 active site 1233100006531 Int/Topo IB signature motif; other site 1233100006532 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1233100006533 ferric uptake regulator; Provisional; Region: fur; PRK09462 1233100006534 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1233100006535 metal binding site 2 [ion binding]; metal-binding site 1233100006536 putative DNA binding helix; other site 1233100006537 metal binding site 1 [ion binding]; metal-binding site 1233100006538 dimer interface [polypeptide binding]; other site 1233100006539 structural Zn2+ binding site [ion binding]; other site 1233100006540 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1233100006541 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1233100006542 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1233100006543 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1233100006544 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1233100006545 NAD(P) binding pocket [chemical binding]; other site 1233100006546 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1233100006547 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1233100006548 Aspartase; Region: Aspartase; cd01357 1233100006549 active sites [active] 1233100006550 tetramer interface [polypeptide binding]; other site 1233100006551 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1233100006552 active site 1233100006553 homodimer interface [polypeptide binding]; other site 1233100006554 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233100006555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100006556 non-specific DNA binding site [nucleotide binding]; other site 1233100006557 salt bridge; other site 1233100006558 sequence-specific DNA binding site [nucleotide binding]; other site 1233100006559 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1233100006560 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1233100006561 dimer interface [polypeptide binding]; other site 1233100006562 ADP-ribose binding site [chemical binding]; other site 1233100006563 active site 1233100006564 nudix motif; other site 1233100006565 metal binding site [ion binding]; metal-binding site 1233100006566 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1233100006567 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233100006568 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233100006569 active site 1233100006570 catalytic tetrad [active] 1233100006571 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1233100006572 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1233100006573 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1233100006574 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1233100006575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1233100006576 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1233100006577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100006578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1233100006579 Coenzyme A binding pocket [chemical binding]; other site 1233100006580 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1233100006581 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1233100006582 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1233100006583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100006584 Coenzyme A binding pocket [chemical binding]; other site 1233100006585 YolD-like protein; Region: YolD; pfam08863 1233100006586 DNA polymerase IV; Reviewed; Region: PRK03103 1233100006587 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1233100006588 active site 1233100006589 DNA binding site [nucleotide binding] 1233100006590 YqzH-like protein; Region: YqzH; pfam14164 1233100006591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100006592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100006593 putative substrate translocation pore; other site 1233100006594 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1233100006595 putative dimer interface [polypeptide binding]; other site 1233100006596 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100006597 ligand binding site [chemical binding]; other site 1233100006598 Zn binding site [ion binding]; other site 1233100006599 pantothenate kinase; Provisional; Region: PRK05439 1233100006600 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1233100006601 ATP-binding site [chemical binding]; other site 1233100006602 CoA-binding site [chemical binding]; other site 1233100006603 Mg2+-binding site [ion binding]; other site 1233100006604 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1233100006605 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1233100006606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233100006607 catalytic residue [active] 1233100006608 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1233100006609 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1233100006610 NADP binding site [chemical binding]; other site 1233100006611 homodimer interface [polypeptide binding]; other site 1233100006612 substrate binding site [chemical binding]; other site 1233100006613 active site 1233100006614 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1233100006615 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1233100006616 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1233100006617 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1233100006618 putative metal binding site [ion binding]; other site 1233100006619 putative dimer interface [polypeptide binding]; other site 1233100006620 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1233100006621 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1233100006622 active site 1233100006623 FMN binding site [chemical binding]; other site 1233100006624 substrate binding site [chemical binding]; other site 1233100006625 homotetramer interface [polypeptide binding]; other site 1233100006626 catalytic residue [active] 1233100006627 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1233100006628 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1233100006629 putative hydrolase; Provisional; Region: PRK02113 1233100006630 ribonuclease Z; Region: RNase_Z; TIGR02651 1233100006631 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1233100006632 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1233100006633 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1233100006634 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1233100006635 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1233100006636 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1233100006637 DNA polymerase IV; Validated; Region: PRK01810 1233100006638 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1233100006639 active site 1233100006640 DNA binding site [nucleotide binding] 1233100006641 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1233100006642 OxaA-like protein precursor; Validated; Region: PRK01622 1233100006643 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 1233100006644 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1233100006645 peptidase T-like protein; Region: PepT-like; TIGR01883 1233100006646 metal binding site [ion binding]; metal-binding site 1233100006647 putative dimer interface [polypeptide binding]; other site 1233100006648 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1233100006649 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1233100006650 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1233100006651 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100006652 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1233100006653 dimer interface [polypeptide binding]; other site 1233100006654 substrate binding site [chemical binding]; other site 1233100006655 metal binding site [ion binding]; metal-binding site 1233100006656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1233100006657 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1233100006658 Predicted membrane protein [Function unknown]; Region: COG4129 1233100006659 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1233100006660 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1233100006661 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1233100006662 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1233100006663 Walker A/P-loop; other site 1233100006664 ATP binding site [chemical binding]; other site 1233100006665 Q-loop/lid; other site 1233100006666 ABC transporter signature motif; other site 1233100006667 Walker B; other site 1233100006668 D-loop; other site 1233100006669 H-loop/switch region; other site 1233100006670 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1233100006671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100006672 dimer interface [polypeptide binding]; other site 1233100006673 conserved gate region; other site 1233100006674 putative PBP binding loops; other site 1233100006675 ABC-ATPase subunit interface; other site 1233100006676 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233100006677 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1233100006678 substrate binding pocket [chemical binding]; other site 1233100006679 membrane-bound complex binding site; other site 1233100006680 hinge residues; other site 1233100006681 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1233100006682 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1233100006683 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1233100006684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100006685 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100006686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1233100006687 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1233100006688 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1233100006689 DNA binding residues [nucleotide binding] 1233100006690 drug binding residues [chemical binding]; other site 1233100006691 dimer interface [polypeptide binding]; other site 1233100006692 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1233100006693 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1233100006694 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1233100006695 E3 interaction surface; other site 1233100006696 lipoyl attachment site [posttranslational modification]; other site 1233100006697 e3 binding domain; Region: E3_binding; pfam02817 1233100006698 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1233100006699 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1233100006700 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1233100006701 alpha subunit interface [polypeptide binding]; other site 1233100006702 TPP binding site [chemical binding]; other site 1233100006703 heterodimer interface [polypeptide binding]; other site 1233100006704 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233100006705 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1233100006706 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1233100006707 tetramer interface [polypeptide binding]; other site 1233100006708 TPP-binding site [chemical binding]; other site 1233100006709 heterodimer interface [polypeptide binding]; other site 1233100006710 phosphorylation loop region [posttranslational modification] 1233100006711 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1233100006712 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1233100006713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100006714 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1233100006715 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233100006716 nucleotide binding site [chemical binding]; other site 1233100006717 Acetokinase family; Region: Acetate_kinase; cl17229 1233100006718 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1233100006719 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1233100006720 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1233100006721 NAD binding site [chemical binding]; other site 1233100006722 Phe binding site; other site 1233100006723 phosphate butyryltransferase; Validated; Region: PRK07742 1233100006724 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1233100006725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100006726 putative active site [active] 1233100006727 heme pocket [chemical binding]; other site 1233100006728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100006729 putative active site [active] 1233100006730 heme pocket [chemical binding]; other site 1233100006731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100006732 Walker A motif; other site 1233100006733 ATP binding site [chemical binding]; other site 1233100006734 Walker B motif; other site 1233100006735 arginine finger; other site 1233100006736 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1233100006737 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1233100006738 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1233100006739 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1233100006740 tetramer interface [polypeptide binding]; other site 1233100006741 active site 1233100006742 Mg2+/Mn2+ binding site [ion binding]; other site 1233100006743 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1233100006744 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1233100006745 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1233100006746 dimer interface [polypeptide binding]; other site 1233100006747 Citrate synthase; Region: Citrate_synt; pfam00285 1233100006748 active site 1233100006749 coenzyme A binding site [chemical binding]; other site 1233100006750 citrylCoA binding site [chemical binding]; other site 1233100006751 oxalacetate/citrate binding site [chemical binding]; other site 1233100006752 catalytic triad [active] 1233100006753 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233100006754 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1233100006755 FAD binding site [chemical binding]; other site 1233100006756 homotetramer interface [polypeptide binding]; other site 1233100006757 substrate binding pocket [chemical binding]; other site 1233100006758 catalytic base [active] 1233100006759 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1233100006760 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1233100006761 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233100006762 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1233100006763 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233100006764 dimer interface [polypeptide binding]; other site 1233100006765 active site 1233100006766 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1233100006767 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1233100006768 active site 1233100006769 catalytic site [active] 1233100006770 metal binding site [ion binding]; metal-binding site 1233100006771 dimer interface [polypeptide binding]; other site 1233100006772 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1233100006773 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1233100006774 active site 1233100006775 metal binding site [ion binding]; metal-binding site 1233100006776 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1233100006777 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1233100006778 putative active site [active] 1233100006779 putative FMN binding site [chemical binding]; other site 1233100006780 putative substrate binding site [chemical binding]; other site 1233100006781 putative catalytic residue [active] 1233100006782 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1233100006783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100006784 active site 1233100006785 phosphorylation site [posttranslational modification] 1233100006786 intermolecular recognition site; other site 1233100006787 dimerization interface [polypeptide binding]; other site 1233100006788 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1233100006789 DNA repair protein RecN; Region: recN; TIGR00634 1233100006790 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1233100006791 Walker A/P-loop; other site 1233100006792 ATP binding site [chemical binding]; other site 1233100006793 Q-loop/lid; other site 1233100006794 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1233100006795 ABC transporter signature motif; other site 1233100006796 Walker B; other site 1233100006797 D-loop; other site 1233100006798 H-loop/switch region; other site 1233100006799 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1233100006800 arginine repressor; Provisional; Region: PRK04280 1233100006801 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1233100006802 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1233100006803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233100006804 RNA binding surface [nucleotide binding]; other site 1233100006805 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1233100006806 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1233100006807 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1233100006808 TPP-binding site; other site 1233100006809 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1233100006810 PYR/PP interface [polypeptide binding]; other site 1233100006811 dimer interface [polypeptide binding]; other site 1233100006812 TPP binding site [chemical binding]; other site 1233100006813 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1233100006814 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1233100006815 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1233100006816 substrate binding pocket [chemical binding]; other site 1233100006817 chain length determination region; other site 1233100006818 substrate-Mg2+ binding site; other site 1233100006819 catalytic residues [active] 1233100006820 aspartate-rich region 1; other site 1233100006821 active site lid residues [active] 1233100006822 aspartate-rich region 2; other site 1233100006823 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1233100006824 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1233100006825 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1233100006826 generic binding surface II; other site 1233100006827 generic binding surface I; other site 1233100006828 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1233100006829 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1233100006830 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1233100006831 homodimer interface [polypeptide binding]; other site 1233100006832 NADP binding site [chemical binding]; other site 1233100006833 substrate binding site [chemical binding]; other site 1233100006834 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1233100006835 putative RNA binding site [nucleotide binding]; other site 1233100006836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1233100006837 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1233100006838 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1233100006839 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1233100006840 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1233100006841 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1233100006842 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1233100006843 carboxyltransferase (CT) interaction site; other site 1233100006844 biotinylation site [posttranslational modification]; other site 1233100006845 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1233100006846 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1233100006847 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1233100006848 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1233100006849 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1233100006850 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1233100006851 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1233100006852 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1233100006853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100006854 Walker A motif; other site 1233100006855 ATP binding site [chemical binding]; other site 1233100006856 Walker B motif; other site 1233100006857 arginine finger; other site 1233100006858 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1233100006859 elongation factor P; Validated; Region: PRK00529 1233100006860 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1233100006861 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1233100006862 RNA binding site [nucleotide binding]; other site 1233100006863 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1233100006864 RNA binding site [nucleotide binding]; other site 1233100006865 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1233100006866 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1233100006867 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1233100006868 active site 1233100006869 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1233100006870 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1233100006871 trimer interface [polypeptide binding]; other site 1233100006872 active site 1233100006873 dimer interface [polypeptide binding]; other site 1233100006874 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1233100006875 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1233100006876 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1233100006877 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1233100006878 active site 1233100006879 nucleophile elbow; other site 1233100006880 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1233100006881 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1233100006882 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1233100006883 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1233100006884 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1233100006885 active site residue [active] 1233100006886 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1233100006887 tetramer interface [polypeptide binding]; other site 1233100006888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100006889 catalytic residue [active] 1233100006890 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1233100006891 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1233100006892 tetramer interface [polypeptide binding]; other site 1233100006893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100006894 catalytic residue [active] 1233100006895 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1233100006896 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1233100006897 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1233100006898 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1233100006899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100006900 ATP binding site [chemical binding]; other site 1233100006901 putative Mg++ binding site [ion binding]; other site 1233100006902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100006903 nucleotide binding region [chemical binding]; other site 1233100006904 ATP-binding site [chemical binding]; other site 1233100006905 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1233100006906 Anti-repressor SinI; Region: SinI; pfam08671 1233100006907 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233100006908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100006909 non-specific DNA binding site [nucleotide binding]; other site 1233100006910 salt bridge; other site 1233100006911 sequence-specific DNA binding site [nucleotide binding]; other site 1233100006912 Anti-repressor SinI; Region: SinI; pfam08671 1233100006913 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1233100006914 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1233100006915 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1233100006916 Catalytic site [active] 1233100006917 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1233100006918 Merozoite surface protein (SPAM); Region: Merozoite_SPAM; pfam07133 1233100006919 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1233100006920 YqzE-like protein; Region: YqzE; pfam14038 1233100006921 ComG operon protein 7; Region: ComGG; pfam14173 1233100006922 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1233100006923 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1233100006924 Type II/IV secretion system protein; Region: T2SE; pfam00437 1233100006925 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1233100006926 Walker A motif; other site 1233100006927 ATP binding site [chemical binding]; other site 1233100006928 Walker B motif; other site 1233100006929 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1233100006930 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1233100006931 Cl binding site [ion binding]; other site 1233100006932 oligomer interface [polypeptide binding]; other site 1233100006933 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1233100006934 Domain of unknown function DUF21; Region: DUF21; pfam01595 1233100006935 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1233100006936 Transporter associated domain; Region: CorC_HlyC; smart01091 1233100006937 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1233100006938 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1233100006939 ArsC family; Region: ArsC; pfam03960 1233100006940 putative catalytic residues [active] 1233100006941 thiol/disulfide switch; other site 1233100006942 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1233100006943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233100006944 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1233100006945 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1233100006946 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1233100006947 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1233100006948 putative active site [active] 1233100006949 Zn binding site [ion binding]; other site 1233100006950 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1233100006951 Sulfatase; Region: Sulfatase; pfam00884 1233100006952 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1233100006953 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233100006954 nucleotide binding site [chemical binding]; other site 1233100006955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1233100006956 Rhomboid family; Region: Rhomboid; pfam01694 1233100006957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100006958 binding surface 1233100006959 TPR motif; other site 1233100006960 TPR repeat; Region: TPR_11; pfam13414 1233100006961 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1233100006962 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1233100006963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233100006964 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1233100006965 YceG-like family; Region: YceG; pfam02618 1233100006966 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1233100006967 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1233100006968 Walker A/P-loop; other site 1233100006969 ATP binding site [chemical binding]; other site 1233100006970 Q-loop/lid; other site 1233100006971 ABC transporter signature motif; other site 1233100006972 Walker B; other site 1233100006973 D-loop; other site 1233100006974 H-loop/switch region; other site 1233100006975 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1233100006976 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1233100006977 Walker A/P-loop; other site 1233100006978 ATP binding site [chemical binding]; other site 1233100006979 Q-loop/lid; other site 1233100006980 ABC transporter signature motif; other site 1233100006981 Walker B; other site 1233100006982 D-loop; other site 1233100006983 H-loop/switch region; other site 1233100006984 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1233100006985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100006986 dimer interface [polypeptide binding]; other site 1233100006987 conserved gate region; other site 1233100006988 ABC-ATPase subunit interface; other site 1233100006989 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1233100006990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100006991 dimer interface [polypeptide binding]; other site 1233100006992 conserved gate region; other site 1233100006993 putative PBP binding loops; other site 1233100006994 ABC-ATPase subunit interface; other site 1233100006995 PBP superfamily domain; Region: PBP_like_2; cl17296 1233100006996 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1233100006997 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1233100006998 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233100006999 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233100007000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100007001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100007002 putative substrate translocation pore; other site 1233100007003 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1233100007004 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1233100007005 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1233100007006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1233100007007 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1233100007008 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100007009 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1233100007010 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1233100007011 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1233100007012 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1233100007013 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1233100007014 ferric uptake regulator; Provisional; Region: fur; PRK09462 1233100007015 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1233100007016 metal binding site 2 [ion binding]; metal-binding site 1233100007017 putative DNA binding helix; other site 1233100007018 metal binding site 1 [ion binding]; metal-binding site 1233100007019 dimer interface [polypeptide binding]; other site 1233100007020 structural Zn2+ binding site [ion binding]; other site 1233100007021 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233100007022 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100007023 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100007024 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233100007025 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1233100007026 endonuclease IV; Provisional; Region: PRK01060 1233100007027 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1233100007028 AP (apurinic/apyrimidinic) site pocket; other site 1233100007029 DNA interaction; other site 1233100007030 Metal-binding active site; metal-binding site 1233100007031 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1233100007032 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1233100007033 ATP binding site [chemical binding]; other site 1233100007034 Mg++ binding site [ion binding]; other site 1233100007035 motif III; other site 1233100007036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100007037 nucleotide binding region [chemical binding]; other site 1233100007038 ATP-binding site [chemical binding]; other site 1233100007039 YqfQ-like protein; Region: YqfQ; pfam14181 1233100007040 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1233100007041 LytB protein; Region: LYTB; pfam02401 1233100007042 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1233100007043 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 1233100007044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1233100007045 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1233100007046 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1233100007047 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1233100007048 Family of unknown function (DUF633); Region: DUF633; pfam04816 1233100007049 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1233100007050 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1233100007051 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1233100007052 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1233100007053 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1233100007054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100007055 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1233100007056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100007057 DNA binding residues [nucleotide binding] 1233100007058 DNA primase; Validated; Region: dnaG; PRK05667 1233100007059 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1233100007060 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1233100007061 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1233100007062 active site 1233100007063 metal binding site [ion binding]; metal-binding site 1233100007064 interdomain interaction site; other site 1233100007065 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1233100007066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1233100007067 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1233100007068 HTH domain; Region: HTH_11; pfam08279 1233100007069 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1233100007070 FOG: CBS domain [General function prediction only]; Region: COG0517 1233100007071 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1233100007072 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1233100007073 dimer interface [polypeptide binding]; other site 1233100007074 motif 1; other site 1233100007075 active site 1233100007076 motif 2; other site 1233100007077 motif 3; other site 1233100007078 Recombination protein O N terminal; Region: RecO_N; pfam11967 1233100007079 DNA repair protein RecO; Region: reco; TIGR00613 1233100007080 Recombination protein O C terminal; Region: RecO_C; pfam02565 1233100007081 YqzL-like protein; Region: YqzL; pfam14006 1233100007082 GTPase Era; Reviewed; Region: era; PRK00089 1233100007083 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1233100007084 G1 box; other site 1233100007085 GTP/Mg2+ binding site [chemical binding]; other site 1233100007086 Switch I region; other site 1233100007087 G2 box; other site 1233100007088 Switch II region; other site 1233100007089 G3 box; other site 1233100007090 G4 box; other site 1233100007091 G5 box; other site 1233100007092 KH domain; Region: KH_2; pfam07650 1233100007093 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1233100007094 active site 1233100007095 catalytic motif [active] 1233100007096 Zn binding site [ion binding]; other site 1233100007097 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1233100007098 metal-binding heat shock protein; Provisional; Region: PRK00016 1233100007099 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1233100007100 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1233100007101 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233100007102 Zn2+ binding site [ion binding]; other site 1233100007103 Mg2+ binding site [ion binding]; other site 1233100007104 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1233100007105 PhoH-like protein; Region: PhoH; pfam02562 1233100007106 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1233100007107 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1233100007108 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1233100007109 hypothetical protein; Provisional; Region: PRK13665 1233100007110 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1233100007111 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1233100007112 dimer interface [polypeptide binding]; other site 1233100007113 active site residues [active] 1233100007114 Yqey-like protein; Region: YqeY; pfam09424 1233100007115 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1233100007116 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1233100007117 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1233100007118 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1233100007119 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1233100007120 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1233100007121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100007122 FeS/SAM binding site; other site 1233100007123 TRAM domain; Region: TRAM; cl01282 1233100007124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1233100007125 RNA methyltransferase, RsmE family; Region: TIGR00046 1233100007126 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1233100007127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100007128 S-adenosylmethionine binding site [chemical binding]; other site 1233100007129 chaperone protein DnaJ; Provisional; Region: PRK14280 1233100007130 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1233100007131 HSP70 interaction site [polypeptide binding]; other site 1233100007132 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1233100007133 substrate binding site [polypeptide binding]; other site 1233100007134 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1233100007135 Zn binding sites [ion binding]; other site 1233100007136 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1233100007137 dimer interface [polypeptide binding]; other site 1233100007138 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1233100007139 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1233100007140 nucleotide binding site [chemical binding]; other site 1233100007141 NEF interaction site [polypeptide binding]; other site 1233100007142 SBD interface [polypeptide binding]; other site 1233100007143 GrpE; Region: GrpE; pfam01025 1233100007144 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1233100007145 dimer interface [polypeptide binding]; other site 1233100007146 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1233100007147 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1233100007148 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1233100007149 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100007150 FeS/SAM binding site; other site 1233100007151 HemN C-terminal domain; Region: HemN_C; pfam06969 1233100007152 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1233100007153 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1233100007154 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1233100007155 germination protease; Provisional; Region: PRK02858 1233100007156 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1233100007157 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1233100007158 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1233100007159 YqzM-like protein; Region: YqzM; pfam14141 1233100007160 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1233100007161 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1233100007162 Competence protein; Region: Competence; pfam03772 1233100007163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233100007164 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1233100007165 catalytic motif [active] 1233100007166 Zn binding site [ion binding]; other site 1233100007167 SLBB domain; Region: SLBB; pfam10531 1233100007168 comEA protein; Region: comE; TIGR01259 1233100007169 Helix-hairpin-helix motif; Region: HHH; pfam00633 1233100007170 late competence protein ComER; Validated; Region: PRK07680 1233100007171 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1233100007172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100007173 S-adenosylmethionine binding site [chemical binding]; other site 1233100007174 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1233100007175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233100007176 Zn2+ binding site [ion binding]; other site 1233100007177 Mg2+ binding site [ion binding]; other site 1233100007178 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1233100007179 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1233100007180 active site 1233100007181 (T/H)XGH motif; other site 1233100007182 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1233100007183 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1233100007184 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1233100007185 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1233100007186 shikimate binding site; other site 1233100007187 NAD(P) binding site [chemical binding]; other site 1233100007188 GTPase YqeH; Provisional; Region: PRK13796 1233100007189 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1233100007190 GTP/Mg2+ binding site [chemical binding]; other site 1233100007191 G4 box; other site 1233100007192 G5 box; other site 1233100007193 G1 box; other site 1233100007194 Switch I region; other site 1233100007195 G2 box; other site 1233100007196 G3 box; other site 1233100007197 Switch II region; other site 1233100007198 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1233100007199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100007200 active site 1233100007201 motif I; other site 1233100007202 motif II; other site 1233100007203 Sporulation inhibitor A; Region: Sda; pfam08970 1233100007204 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1233100007205 active site 1233100007206 catalytic triad [active] 1233100007207 oxyanion hole [active] 1233100007208 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1233100007209 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233100007210 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1233100007211 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1233100007212 arginine decarboxylase; Provisional; Region: PRK15029 1233100007213 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1233100007214 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1233100007215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100007216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100007217 DNA binding residues [nucleotide binding] 1233100007218 Predicted membrane protein [Function unknown]; Region: COG3223 1233100007219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100007220 HAMP domain; Region: HAMP; pfam00672 1233100007221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100007222 dimer interface [polypeptide binding]; other site 1233100007223 phosphorylation site [posttranslational modification] 1233100007224 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1233100007225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100007226 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1233100007227 active site 1233100007228 phosphorylation site [posttranslational modification] 1233100007229 intermolecular recognition site; other site 1233100007230 dimerization interface [polypeptide binding]; other site 1233100007231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100007232 DNA binding site [nucleotide binding] 1233100007233 Predicted membrane protein [Function unknown]; Region: COG2311 1233100007234 Protein of unknown function (DUF418); Region: DUF418; cl12135 1233100007235 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1233100007236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100007237 Coenzyme A binding pocket [chemical binding]; other site 1233100007238 Predicted transcriptional regulators [Transcription]; Region: COG1733 1233100007239 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1233100007240 short chain dehydrogenase; Provisional; Region: PRK06500 1233100007241 classical (c) SDRs; Region: SDR_c; cd05233 1233100007242 NAD(P) binding site [chemical binding]; other site 1233100007243 active site 1233100007244 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1233100007245 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1233100007246 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1233100007247 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1233100007248 Predicted transcriptional regulators [Transcription]; Region: COG1695 1233100007249 hypothetical protein; Validated; Region: PRK06217 1233100007250 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1233100007251 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1233100007252 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1233100007253 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1233100007254 active site residue [active] 1233100007255 EVE domain; Region: EVE; cl00728 1233100007256 LXG domain of WXG superfamily; Region: LXG; pfam04740 1233100007257 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1233100007258 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1233100007259 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 1233100007260 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1233100007261 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1233100007262 DNA binding residues [nucleotide binding] 1233100007263 dimer interface [polypeptide binding]; other site 1233100007264 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1233100007265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100007266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100007267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100007268 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1233100007269 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1233100007270 Coenzyme A binding pocket [chemical binding]; other site 1233100007271 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1233100007272 Domain of unknown function DUF21; Region: DUF21; pfam01595 1233100007273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1233100007274 Transporter associated domain; Region: CorC_HlyC; smart01091 1233100007275 YrzO-like protein; Region: YrzO; pfam14142 1233100007276 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1233100007277 EamA-like transporter family; Region: EamA; pfam00892 1233100007278 EamA-like transporter family; Region: EamA; pfam00892 1233100007279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100007280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100007281 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1233100007282 putative dimerization interface [polypeptide binding]; other site 1233100007283 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1233100007284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1233100007285 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1233100007286 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1233100007287 Tautomerase enzyme; Region: Tautomerase; pfam01361 1233100007288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100007289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100007290 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1233100007291 putative dimerization interface [polypeptide binding]; other site 1233100007292 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1233100007293 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1233100007294 4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346 1233100007295 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1233100007296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100007297 putative DNA binding site [nucleotide binding]; other site 1233100007298 putative Zn2+ binding site [ion binding]; other site 1233100007299 AsnC family; Region: AsnC_trans_reg; pfam01037 1233100007300 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1233100007301 RNAase interaction site [polypeptide binding]; other site 1233100007302 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1233100007303 Cytochrome P450; Region: p450; cl12078 1233100007304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1233100007305 Coenzyme A binding pocket [chemical binding]; other site 1233100007306 Isochorismatase family; Region: Isochorismatase; pfam00857 1233100007307 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1233100007308 catalytic triad [active] 1233100007309 conserved cis-peptide bond; other site 1233100007310 DinB family; Region: DinB; pfam05163 1233100007311 DinB superfamily; Region: DinB_2; pfam12867 1233100007312 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1233100007313 Nitronate monooxygenase; Region: NMO; pfam03060 1233100007314 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1233100007315 FMN binding site [chemical binding]; other site 1233100007316 substrate binding site [chemical binding]; other site 1233100007317 putative catalytic residue [active] 1233100007318 glutamate racemase; Region: glut_race; TIGR00067 1233100007319 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1233100007320 putative binding site; other site 1233100007321 putative dimer interface [polypeptide binding]; other site 1233100007322 YodA lipocalin-like domain; Region: YodA; pfam09223 1233100007323 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 1233100007324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100007325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100007326 DNA binding residues [nucleotide binding] 1233100007327 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233100007328 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233100007329 active site 1233100007330 catalytic tetrad [active] 1233100007331 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1233100007332 chitosan binding site [chemical binding]; other site 1233100007333 catalytic residues [active] 1233100007334 Mor transcription activator family; Region: Mor; cl02360 1233100007335 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1233100007336 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1233100007337 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1233100007338 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233100007339 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1233100007340 Bacterial SH3 domain; Region: SH3_3; cl17532 1233100007341 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1233100007342 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100007343 active site 1233100007344 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1233100007345 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1233100007346 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1233100007347 NAD binding site [chemical binding]; other site 1233100007348 catalytic Zn binding site [ion binding]; other site 1233100007349 structural Zn binding site [ion binding]; other site 1233100007350 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1233100007351 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1233100007352 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1233100007353 DNA binding residues [nucleotide binding] 1233100007354 putative dimer interface [polypeptide binding]; other site 1233100007355 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1233100007356 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1233100007357 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1233100007358 putative NAD(P) binding site [chemical binding]; other site 1233100007359 putative substrate binding site [chemical binding]; other site 1233100007360 catalytic Zn binding site [ion binding]; other site 1233100007361 structural Zn binding site [ion binding]; other site 1233100007362 dimer interface [polypeptide binding]; other site 1233100007363 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1233100007364 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1233100007365 proposed catalytic triad [active] 1233100007366 conserved cys residue [active] 1233100007367 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1233100007368 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1233100007369 substrate binding [chemical binding]; other site 1233100007370 active site 1233100007371 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1233100007372 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1233100007373 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1233100007374 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1233100007375 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1233100007376 active site 1233100007377 phosphorylation site [posttranslational modification] 1233100007378 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1233100007379 active pocket/dimerization site; other site 1233100007380 active site 1233100007381 phosphorylation site [posttranslational modification] 1233100007382 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1233100007383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100007384 Walker A motif; other site 1233100007385 ATP binding site [chemical binding]; other site 1233100007386 Walker B motif; other site 1233100007387 arginine finger; other site 1233100007388 Transcriptional antiterminator [Transcription]; Region: COG3933 1233100007389 PRD domain; Region: PRD; pfam00874 1233100007390 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1233100007391 active pocket/dimerization site; other site 1233100007392 active site 1233100007393 phosphorylation site [posttranslational modification] 1233100007394 PRD domain; Region: PRD; pfam00874 1233100007395 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1233100007396 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1233100007397 Predicted transcriptional regulators [Transcription]; Region: COG1378 1233100007398 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1233100007399 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1233100007400 C-terminal domain interface [polypeptide binding]; other site 1233100007401 sugar binding site [chemical binding]; other site 1233100007402 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1233100007403 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1233100007404 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1233100007405 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1233100007406 catalytic triad [active] 1233100007407 catalytic triad [active] 1233100007408 oxyanion hole [active] 1233100007409 YrhK-like protein; Region: YrhK; pfam14145 1233100007410 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1233100007411 Cytochrome P450; Region: p450; pfam00067 1233100007412 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1233100007413 Flavodoxin; Region: Flavodoxin_1; pfam00258 1233100007414 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1233100007415 FAD binding pocket [chemical binding]; other site 1233100007416 FAD binding motif [chemical binding]; other site 1233100007417 catalytic residues [active] 1233100007418 NAD binding pocket [chemical binding]; other site 1233100007419 phosphate binding motif [ion binding]; other site 1233100007420 beta-alpha-beta structure motif; other site 1233100007421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100007422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100007423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100007424 S-adenosylmethionine binding site [chemical binding]; other site 1233100007425 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1233100007426 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1233100007427 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1233100007428 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1233100007429 catalytic loop [active] 1233100007430 iron binding site [ion binding]; other site 1233100007431 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1233100007432 4Fe-4S binding domain; Region: Fer4; pfam00037 1233100007433 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1233100007434 [4Fe-4S] binding site [ion binding]; other site 1233100007435 molybdopterin cofactor binding site; other site 1233100007436 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1233100007437 molybdopterin cofactor binding site; other site 1233100007438 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1233100007439 YrhC-like protein; Region: YrhC; pfam14143 1233100007440 cystathionine beta-lyase; Provisional; Region: PRK07671 1233100007441 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1233100007442 homodimer interface [polypeptide binding]; other site 1233100007443 substrate-cofactor binding pocket; other site 1233100007444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100007445 catalytic residue [active] 1233100007446 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1233100007447 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1233100007448 dimer interface [polypeptide binding]; other site 1233100007449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100007450 catalytic residue [active] 1233100007451 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1233100007452 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1233100007453 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1233100007454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100007455 S-adenosylmethionine binding site [chemical binding]; other site 1233100007456 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1233100007457 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1233100007458 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1233100007459 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1233100007460 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1233100007461 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1233100007462 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1233100007463 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1233100007464 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1233100007465 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1233100007466 ATP-binding site [chemical binding]; other site 1233100007467 Sugar specificity; other site 1233100007468 Pyrimidine base specificity; other site 1233100007469 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1233100007470 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1233100007471 Peptidase family U32; Region: Peptidase_U32; pfam01136 1233100007472 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1233100007473 Peptidase family U32; Region: Peptidase_U32; pfam01136 1233100007474 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1233100007475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100007476 S-adenosylmethionine binding site [chemical binding]; other site 1233100007477 conserved hypothetical protein, YceG family; Region: TIGR00247 1233100007478 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1233100007479 dimerization interface [polypeptide binding]; other site 1233100007480 hypothetical protein; Provisional; Region: PRK13678 1233100007481 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1233100007482 hypothetical protein; Provisional; Region: PRK05473 1233100007483 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1233100007484 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1233100007485 motif 1; other site 1233100007486 active site 1233100007487 motif 2; other site 1233100007488 motif 3; other site 1233100007489 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1233100007490 DHHA1 domain; Region: DHHA1; pfam02272 1233100007491 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1233100007492 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1233100007493 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1233100007494 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1233100007495 Walker A/P-loop; other site 1233100007496 ATP binding site [chemical binding]; other site 1233100007497 Q-loop/lid; other site 1233100007498 ABC transporter signature motif; other site 1233100007499 Walker B; other site 1233100007500 D-loop; other site 1233100007501 H-loop/switch region; other site 1233100007502 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1233100007503 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233100007504 substrate binding pocket [chemical binding]; other site 1233100007505 membrane-bound complex binding site; other site 1233100007506 hinge residues; other site 1233100007507 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1233100007508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100007509 dimer interface [polypeptide binding]; other site 1233100007510 conserved gate region; other site 1233100007511 putative PBP binding loops; other site 1233100007512 ABC-ATPase subunit interface; other site 1233100007513 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1233100007514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100007515 dimer interface [polypeptide binding]; other site 1233100007516 ABC-ATPase subunit interface; other site 1233100007517 putative PBP binding loops; other site 1233100007518 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1233100007519 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1233100007520 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1233100007521 AAA domain; Region: AAA_30; pfam13604 1233100007522 Family description; Region: UvrD_C_2; pfam13538 1233100007523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100007524 binding surface 1233100007525 TPR motif; other site 1233100007526 TPR repeat; Region: TPR_11; pfam13414 1233100007527 TPR repeat; Region: TPR_11; pfam13414 1233100007528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100007529 binding surface 1233100007530 TPR motif; other site 1233100007531 TPR repeat; Region: TPR_11; pfam13414 1233100007532 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1233100007533 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1233100007534 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1233100007535 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1233100007536 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233100007537 catalytic residue [active] 1233100007538 Predicted transcriptional regulator [Transcription]; Region: COG1959 1233100007539 Transcriptional regulator; Region: Rrf2; pfam02082 1233100007540 recombination factor protein RarA; Reviewed; Region: PRK13342 1233100007541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100007542 Walker A motif; other site 1233100007543 ATP binding site [chemical binding]; other site 1233100007544 Walker B motif; other site 1233100007545 arginine finger; other site 1233100007546 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1233100007547 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1233100007548 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1233100007549 putative ATP binding site [chemical binding]; other site 1233100007550 putative substrate interface [chemical binding]; other site 1233100007551 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1233100007552 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1233100007553 dimer interface [polypeptide binding]; other site 1233100007554 anticodon binding site; other site 1233100007555 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1233100007556 homodimer interface [polypeptide binding]; other site 1233100007557 motif 1; other site 1233100007558 active site 1233100007559 motif 2; other site 1233100007560 GAD domain; Region: GAD; pfam02938 1233100007561 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1233100007562 motif 3; other site 1233100007563 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1233100007564 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1233100007565 dimer interface [polypeptide binding]; other site 1233100007566 motif 1; other site 1233100007567 active site 1233100007568 motif 2; other site 1233100007569 motif 3; other site 1233100007570 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1233100007571 anticodon binding site; other site 1233100007572 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1233100007573 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233100007574 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233100007575 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233100007576 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233100007577 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1233100007578 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1233100007579 active site 1233100007580 metal binding site [ion binding]; metal-binding site 1233100007581 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1233100007582 putative active site [active] 1233100007583 dimerization interface [polypeptide binding]; other site 1233100007584 putative tRNAtyr binding site [nucleotide binding]; other site 1233100007585 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1233100007586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233100007587 Zn2+ binding site [ion binding]; other site 1233100007588 Mg2+ binding site [ion binding]; other site 1233100007589 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1233100007590 synthetase active site [active] 1233100007591 NTP binding site [chemical binding]; other site 1233100007592 metal binding site [ion binding]; metal-binding site 1233100007593 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1233100007594 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1233100007595 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100007596 active site 1233100007597 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1233100007598 DHH family; Region: DHH; pfam01368 1233100007599 DHHA1 domain; Region: DHHA1; pfam02272 1233100007600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1233100007601 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1233100007602 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1233100007603 TrkA-C domain; Region: TrkA_C; pfam02080 1233100007604 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1233100007605 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1233100007606 Protein export membrane protein; Region: SecD_SecF; pfam02355 1233100007607 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1233100007608 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1233100007609 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1233100007610 Predicted membrane protein [Function unknown]; Region: COG2323 1233100007611 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1233100007612 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1233100007613 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1233100007614 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1233100007615 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1233100007616 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1233100007617 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1233100007618 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1233100007619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100007620 Walker A motif; other site 1233100007621 ATP binding site [chemical binding]; other site 1233100007622 Walker B motif; other site 1233100007623 arginine finger; other site 1233100007624 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1233100007625 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1233100007626 RuvA N terminal domain; Region: RuvA_N; pfam01330 1233100007627 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1233100007628 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1233100007629 BofC C-terminal domain; Region: BofC_C; pfam08955 1233100007630 polyol permease family; Region: 2A0118; TIGR00897 1233100007631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100007632 putative substrate translocation pore; other site 1233100007633 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233100007634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233100007635 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233100007636 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1233100007637 active site 1233100007638 substrate binding site [chemical binding]; other site 1233100007639 ATP binding site [chemical binding]; other site 1233100007640 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1233100007641 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1233100007642 hypothetical protein; Validated; Region: PRK00110 1233100007643 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1233100007644 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100007645 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1233100007646 quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550 1233100007647 L-aspartate oxidase; Provisional; Region: PRK08071 1233100007648 L-aspartate oxidase; Provisional; Region: PRK06175 1233100007649 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1233100007650 cysteine desulfurase; Provisional; Region: PRK02948 1233100007651 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1233100007652 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233100007653 catalytic residue [active] 1233100007654 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1233100007655 HTH domain; Region: HTH_11; pfam08279 1233100007656 3H domain; Region: 3H; pfam02829 1233100007657 prephenate dehydratase; Provisional; Region: PRK11898 1233100007658 Prephenate dehydratase; Region: PDT; pfam00800 1233100007659 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1233100007660 putative L-Phe binding site [chemical binding]; other site 1233100007661 hypothetical protein; Provisional; Region: PRK04435 1233100007662 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1233100007663 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1233100007664 GTP1/OBG; Region: GTP1_OBG; pfam01018 1233100007665 Obg GTPase; Region: Obg; cd01898 1233100007666 G1 box; other site 1233100007667 GTP/Mg2+ binding site [chemical binding]; other site 1233100007668 Switch I region; other site 1233100007669 G2 box; other site 1233100007670 G3 box; other site 1233100007671 Switch II region; other site 1233100007672 G4 box; other site 1233100007673 G5 box; other site 1233100007674 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1233100007675 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1233100007676 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1233100007677 hypothetical protein; Provisional; Region: PRK14553 1233100007678 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1233100007679 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1233100007680 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1233100007681 active site 1233100007682 Peptidase family M50; Region: Peptidase_M50; pfam02163 1233100007683 putative substrate binding region [chemical binding]; other site 1233100007684 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1233100007685 Peptidase family M23; Region: Peptidase_M23; pfam01551 1233100007686 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1233100007687 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1233100007688 Switch I; other site 1233100007689 Switch II; other site 1233100007690 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1233100007691 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1233100007692 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1233100007693 rod shape-determining protein MreC; Region: mreC; TIGR00219 1233100007694 rod shape-determining protein MreC; Region: MreC; pfam04085 1233100007695 rod shape-determining protein MreB; Provisional; Region: PRK13927 1233100007696 MreB and similar proteins; Region: MreB_like; cd10225 1233100007697 nucleotide binding site [chemical binding]; other site 1233100007698 Mg binding site [ion binding]; other site 1233100007699 putative protofilament interaction site [polypeptide binding]; other site 1233100007700 RodZ interaction site [polypeptide binding]; other site 1233100007701 hypothetical protein; Reviewed; Region: PRK00024 1233100007702 Helix-hairpin-helix motif; Region: HHH; pfam00633 1233100007703 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1233100007704 MPN+ (JAMM) motif; other site 1233100007705 Zinc-binding site [ion binding]; other site 1233100007706 Maf-like protein; Region: Maf; pfam02545 1233100007707 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1233100007708 active site 1233100007709 dimer interface [polypeptide binding]; other site 1233100007710 Sporulation related domain; Region: SPOR; pfam05036 1233100007711 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1233100007712 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1233100007713 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1233100007714 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1233100007715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233100007716 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233100007717 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1233100007718 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1233100007719 active site 1233100007720 HIGH motif; other site 1233100007721 nucleotide binding site [chemical binding]; other site 1233100007722 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1233100007723 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1233100007724 active site 1233100007725 KMSKS motif; other site 1233100007726 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1233100007727 tRNA binding surface [nucleotide binding]; other site 1233100007728 anticodon binding site; other site 1233100007729 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1233100007730 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1233100007731 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1233100007732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1233100007733 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1233100007734 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233100007735 inhibitor-cofactor binding pocket; inhibition site 1233100007736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100007737 catalytic residue [active] 1233100007738 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1233100007739 dimer interface [polypeptide binding]; other site 1233100007740 active site 1233100007741 Schiff base residues; other site 1233100007742 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1233100007743 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1233100007744 domain interfaces; other site 1233100007745 active site 1233100007746 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1233100007747 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1233100007748 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1233100007749 tRNA; other site 1233100007750 putative tRNA binding site [nucleotide binding]; other site 1233100007751 putative NADP binding site [chemical binding]; other site 1233100007752 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1233100007753 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1233100007754 G1 box; other site 1233100007755 GTP/Mg2+ binding site [chemical binding]; other site 1233100007756 Switch I region; other site 1233100007757 G2 box; other site 1233100007758 G3 box; other site 1233100007759 Switch II region; other site 1233100007760 G4 box; other site 1233100007761 G5 box; other site 1233100007762 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1233100007763 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1233100007764 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1233100007765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100007766 Walker A motif; other site 1233100007767 ATP binding site [chemical binding]; other site 1233100007768 Walker B motif; other site 1233100007769 arginine finger; other site 1233100007770 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1233100007771 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1233100007772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100007773 Walker A motif; other site 1233100007774 ATP binding site [chemical binding]; other site 1233100007775 Walker B motif; other site 1233100007776 arginine finger; other site 1233100007777 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1233100007778 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1233100007779 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1233100007780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100007781 Walker A motif; other site 1233100007782 ATP binding site [chemical binding]; other site 1233100007783 Walker B motif; other site 1233100007784 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1233100007785 trigger factor; Provisional; Region: tig; PRK01490 1233100007786 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1233100007787 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1233100007788 TPR repeat; Region: TPR_11; pfam13414 1233100007789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100007790 binding surface 1233100007791 TPR motif; other site 1233100007792 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1233100007793 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1233100007794 substrate binding site [chemical binding]; other site 1233100007795 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1233100007796 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1233100007797 substrate binding site [chemical binding]; other site 1233100007798 ligand binding site [chemical binding]; other site 1233100007799 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1233100007800 tartrate dehydrogenase; Region: TTC; TIGR02089 1233100007801 2-isopropylmalate synthase; Validated; Region: PRK00915 1233100007802 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1233100007803 active site 1233100007804 metal binding site [ion binding]; metal-binding site 1233100007805 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1233100007806 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1233100007807 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1233100007808 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1233100007809 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1233100007810 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1233100007811 putative valine binding site [chemical binding]; other site 1233100007812 dimer interface [polypeptide binding]; other site 1233100007813 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1233100007814 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1233100007815 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1233100007816 PYR/PP interface [polypeptide binding]; other site 1233100007817 dimer interface [polypeptide binding]; other site 1233100007818 TPP binding site [chemical binding]; other site 1233100007819 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1233100007820 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1233100007821 TPP-binding site [chemical binding]; other site 1233100007822 dimer interface [polypeptide binding]; other site 1233100007823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1233100007824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100007825 Coenzyme A binding pocket [chemical binding]; other site 1233100007826 Heat induced stress protein YflT; Region: YflT; pfam11181 1233100007827 conserved domain; Region: TIGR02271 1233100007828 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1233100007829 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1233100007830 active site 1233100007831 metal binding site [ion binding]; metal-binding site 1233100007832 homotetramer interface [polypeptide binding]; other site 1233100007833 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1233100007834 active site 1233100007835 dimerization interface [polypeptide binding]; other site 1233100007836 ribonuclease PH; Reviewed; Region: rph; PRK00173 1233100007837 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1233100007838 hexamer interface [polypeptide binding]; other site 1233100007839 active site 1233100007840 Spore germination protein [General function prediction only]; Region: COG5401 1233100007841 Sporulation and spore germination; Region: Germane; pfam10646 1233100007842 Sporulation and spore germination; Region: Germane; pfam10646 1233100007843 glutamate racemase; Region: glut_race; TIGR00067 1233100007844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100007845 MarR family; Region: MarR; pfam01047 1233100007846 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233100007847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233100007848 DNA binding residues [nucleotide binding] 1233100007849 dimerization interface [polypeptide binding]; other site 1233100007850 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1233100007851 active site 1233100007852 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1233100007853 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1233100007854 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1233100007855 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1233100007856 L-aspartate oxidase; Provisional; Region: PRK06175 1233100007857 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1233100007858 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1233100007859 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1233100007860 proximal heme binding site [chemical binding]; other site 1233100007861 distal heme binding site [chemical binding]; other site 1233100007862 putative dimer interface [polypeptide binding]; other site 1233100007863 putative Iron-sulfur protein interface [polypeptide binding]; other site 1233100007864 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1233100007865 aspartate kinase; Reviewed; Region: PRK06635 1233100007866 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1233100007867 putative nucleotide binding site [chemical binding]; other site 1233100007868 putative catalytic residues [active] 1233100007869 putative Mg ion binding site [ion binding]; other site 1233100007870 putative aspartate binding site [chemical binding]; other site 1233100007871 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1233100007872 putative allosteric regulatory site; other site 1233100007873 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1233100007874 putative allosteric regulatory residue; other site 1233100007875 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1233100007876 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1233100007877 GIY-YIG motif/motif A; other site 1233100007878 active site 1233100007879 catalytic site [active] 1233100007880 putative DNA binding site [nucleotide binding]; other site 1233100007881 metal binding site [ion binding]; metal-binding site 1233100007882 UvrB/uvrC motif; Region: UVR; pfam02151 1233100007883 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1233100007884 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233100007885 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1233100007886 catalytic residues [active] 1233100007887 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1233100007888 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1233100007889 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1233100007890 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1233100007891 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1233100007892 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1233100007893 Ligand binding site [chemical binding]; other site 1233100007894 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1233100007895 enoyl-CoA hydratase; Provisional; Region: PRK07658 1233100007896 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233100007897 substrate binding site [chemical binding]; other site 1233100007898 oxyanion hole (OAH) forming residues; other site 1233100007899 trimer interface [polypeptide binding]; other site 1233100007900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100007901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100007902 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1233100007903 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1233100007904 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1233100007905 acyl-activating enzyme (AAE) consensus motif; other site 1233100007906 putative AMP binding site [chemical binding]; other site 1233100007907 putative active site [active] 1233100007908 putative CoA binding site [chemical binding]; other site 1233100007909 Predicted membrane protein [Function unknown]; Region: COG3766 1233100007910 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1233100007911 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1233100007912 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1233100007913 MutS domain III; Region: MutS_III; pfam05192 1233100007914 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1233100007915 Walker A/P-loop; other site 1233100007916 ATP binding site [chemical binding]; other site 1233100007917 Q-loop/lid; other site 1233100007918 ABC transporter signature motif; other site 1233100007919 Walker B; other site 1233100007920 D-loop; other site 1233100007921 H-loop/switch region; other site 1233100007922 Smr domain; Region: Smr; pfam01713 1233100007923 hypothetical protein; Provisional; Region: PRK08609 1233100007924 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1233100007925 active site 1233100007926 primer binding site [nucleotide binding]; other site 1233100007927 NTP binding site [chemical binding]; other site 1233100007928 metal binding triad [ion binding]; metal-binding site 1233100007929 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1233100007930 active site 1233100007931 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1233100007932 Colicin V production protein; Region: Colicin_V; pfam02674 1233100007933 cell division protein ZapA; Provisional; Region: PRK14126 1233100007934 ribonuclease HIII; Provisional; Region: PRK00996 1233100007935 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1233100007936 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1233100007937 RNA/DNA hybrid binding site [nucleotide binding]; other site 1233100007938 active site 1233100007939 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1233100007940 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1233100007941 putative tRNA-binding site [nucleotide binding]; other site 1233100007942 B3/4 domain; Region: B3_4; pfam03483 1233100007943 tRNA synthetase B5 domain; Region: B5; smart00874 1233100007944 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1233100007945 dimer interface [polypeptide binding]; other site 1233100007946 motif 1; other site 1233100007947 motif 3; other site 1233100007948 motif 2; other site 1233100007949 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1233100007950 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1233100007951 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1233100007952 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1233100007953 dimer interface [polypeptide binding]; other site 1233100007954 motif 1; other site 1233100007955 active site 1233100007956 motif 2; other site 1233100007957 motif 3; other site 1233100007958 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1233100007959 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1233100007960 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1233100007961 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1233100007962 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1233100007963 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1233100007964 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233100007965 FAD binding domain; Region: FAD_binding_4; pfam01565 1233100007966 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1233100007967 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1233100007968 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1233100007969 Cysteine-rich domain; Region: CCG; pfam02754 1233100007970 Cysteine-rich domain; Region: CCG; pfam02754 1233100007971 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1233100007972 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100007973 active site 1233100007974 metal binding site [ion binding]; metal-binding site 1233100007975 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1233100007976 Carbon starvation protein CstA; Region: CstA; pfam02554 1233100007977 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1233100007978 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1233100007979 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1233100007980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233100007981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100007982 putative PBP binding loops; other site 1233100007983 dimer interface [polypeptide binding]; other site 1233100007984 ABC-ATPase subunit interface; other site 1233100007985 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233100007986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100007987 dimer interface [polypeptide binding]; other site 1233100007988 conserved gate region; other site 1233100007989 putative PBP binding loops; other site 1233100007990 ABC-ATPase subunit interface; other site 1233100007991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233100007992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233100007993 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1233100007994 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1233100007995 active site 1233100007996 metal binding site [ion binding]; metal-binding site 1233100007997 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1233100007998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100007999 active site 1233100008000 motif I; other site 1233100008001 motif II; other site 1233100008002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100008003 motif II; other site 1233100008004 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1233100008005 L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760 1233100008006 intersubunit interface [polypeptide binding]; other site 1233100008007 active site 1233100008008 Zn2+ binding site [ion binding]; other site 1233100008009 L-ribulokinase; Region: L-ribulokinase; TIGR01234 1233100008010 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1233100008011 N- and C-terminal domain interface [polypeptide binding]; other site 1233100008012 active site 1233100008013 MgATP binding site [chemical binding]; other site 1233100008014 catalytic site [active] 1233100008015 metal binding site [ion binding]; metal-binding site 1233100008016 carbohydrate binding site [chemical binding]; other site 1233100008017 homodimer interface [polypeptide binding]; other site 1233100008018 L-arabinose isomerase; Provisional; Region: PRK02929 1233100008019 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1233100008020 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1233100008021 trimer interface [polypeptide binding]; other site 1233100008022 putative substrate binding site [chemical binding]; other site 1233100008023 putative metal binding site [ion binding]; other site 1233100008024 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1233100008025 substrate binding site [chemical binding]; other site 1233100008026 active site 1233100008027 Predicted membrane protein [Function unknown]; Region: COG3326 1233100008028 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1233100008029 L21 binding site [polypeptide binding]; other site 1233100008030 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1233100008031 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1233100008032 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1233100008033 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1233100008034 antiholin-like protein LrgB; Provisional; Region: PRK04288 1233100008035 LrgA family; Region: LrgA; cl00608 1233100008036 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1233100008037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100008038 active site 1233100008039 phosphorylation site [posttranslational modification] 1233100008040 intermolecular recognition site; other site 1233100008041 dimerization interface [polypeptide binding]; other site 1233100008042 LytTr DNA-binding domain; Region: LytTR; pfam04397 1233100008043 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1233100008044 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1233100008045 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1233100008046 Histidine kinase; Region: His_kinase; pfam06580 1233100008047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100008048 ATP binding site [chemical binding]; other site 1233100008049 Mg2+ binding site [ion binding]; other site 1233100008050 G-X-G motif; other site 1233100008051 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1233100008052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100008053 motif II; other site 1233100008054 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1233100008055 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1233100008056 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1233100008057 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1233100008058 active site 1233100008059 dimer interface [polypeptide binding]; other site 1233100008060 motif 1; other site 1233100008061 motif 2; other site 1233100008062 motif 3; other site 1233100008063 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1233100008064 anticodon binding site; other site 1233100008065 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 1233100008066 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1233100008067 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1233100008068 primosomal protein DnaI; Reviewed; Region: PRK08939 1233100008069 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1233100008070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100008071 Walker A motif; other site 1233100008072 ATP binding site [chemical binding]; other site 1233100008073 Walker B motif; other site 1233100008074 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1233100008075 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1233100008076 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1233100008077 ATP cone domain; Region: ATP-cone; pfam03477 1233100008078 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1233100008079 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1233100008080 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1233100008081 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1233100008082 Predicted transcriptional regulators [Transcription]; Region: COG1733 1233100008083 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1233100008084 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1233100008085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100008086 putative substrate translocation pore; other site 1233100008087 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233100008088 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233100008089 active site 1233100008090 catalytic tetrad [active] 1233100008091 dephospho-CoA kinase; Region: TIGR00152 1233100008092 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1233100008093 ATP-binding [chemical binding]; other site 1233100008094 CoA-binding site [chemical binding]; other site 1233100008095 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1233100008096 Domain of unknown function DUF; Region: DUF204; pfam02659 1233100008097 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1233100008098 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1233100008099 DNA binding site [nucleotide binding] 1233100008100 catalytic residue [active] 1233100008101 H2TH interface [polypeptide binding]; other site 1233100008102 putative catalytic residues [active] 1233100008103 turnover-facilitating residue; other site 1233100008104 intercalation triad [nucleotide binding]; other site 1233100008105 8OG recognition residue [nucleotide binding]; other site 1233100008106 putative reading head residues; other site 1233100008107 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1233100008108 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1233100008109 DNA polymerase I; Provisional; Region: PRK05755 1233100008110 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1233100008111 active site 1233100008112 metal binding site 1 [ion binding]; metal-binding site 1233100008113 putative 5' ssDNA interaction site; other site 1233100008114 metal binding site 3; metal-binding site 1233100008115 metal binding site 2 [ion binding]; metal-binding site 1233100008116 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1233100008117 putative DNA binding site [nucleotide binding]; other site 1233100008118 putative metal binding site [ion binding]; other site 1233100008119 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1233100008120 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1233100008121 active site 1233100008122 DNA binding site [nucleotide binding] 1233100008123 catalytic site [active] 1233100008124 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1233100008125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100008126 putative active site [active] 1233100008127 heme pocket [chemical binding]; other site 1233100008128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100008129 dimer interface [polypeptide binding]; other site 1233100008130 phosphorylation site [posttranslational modification] 1233100008131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100008132 ATP binding site [chemical binding]; other site 1233100008133 Mg2+ binding site [ion binding]; other site 1233100008134 G-X-G motif; other site 1233100008135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100008136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100008137 active site 1233100008138 phosphorylation site [posttranslational modification] 1233100008139 intermolecular recognition site; other site 1233100008140 dimerization interface [polypeptide binding]; other site 1233100008141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100008142 DNA binding site [nucleotide binding] 1233100008143 malate dehydrogenase; Reviewed; Region: PRK06223 1233100008144 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1233100008145 NAD(P) binding site [chemical binding]; other site 1233100008146 dimer interface [polypeptide binding]; other site 1233100008147 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233100008148 substrate binding site [chemical binding]; other site 1233100008149 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1233100008150 isocitrate dehydrogenase; Validated; Region: PRK07362 1233100008151 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1233100008152 dimer interface [polypeptide binding]; other site 1233100008153 Citrate synthase; Region: Citrate_synt; pfam00285 1233100008154 active site 1233100008155 citrylCoA binding site [chemical binding]; other site 1233100008156 oxalacetate/citrate binding site [chemical binding]; other site 1233100008157 coenzyme A binding site [chemical binding]; other site 1233100008158 catalytic triad [active] 1233100008159 Predicted membrane protein [Function unknown]; Region: COG2707 1233100008160 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1233100008161 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1233100008162 pyruvate kinase; Provisional; Region: PRK06354 1233100008163 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1233100008164 active site 1233100008165 domain interfaces; other site 1233100008166 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1233100008167 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1233100008168 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1233100008169 active site 1233100008170 ADP/pyrophosphate binding site [chemical binding]; other site 1233100008171 dimerization interface [polypeptide binding]; other site 1233100008172 allosteric effector site; other site 1233100008173 fructose-1,6-bisphosphate binding site; other site 1233100008174 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1233100008175 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1233100008176 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1233100008177 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1233100008178 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1233100008179 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1233100008180 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1233100008181 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1233100008182 putative NAD(P) binding site [chemical binding]; other site 1233100008183 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1233100008184 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1233100008185 active site 1233100008186 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1233100008187 generic binding surface I; other site 1233100008188 generic binding surface II; other site 1233100008189 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1233100008190 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1233100008191 DHH family; Region: DHH; pfam01368 1233100008192 DHHA1 domain; Region: DHHA1; pfam02272 1233100008193 YtpI-like protein; Region: YtpI; pfam14007 1233100008194 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1233100008195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100008196 DNA-binding site [nucleotide binding]; DNA binding site 1233100008197 DRTGG domain; Region: DRTGG; pfam07085 1233100008198 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1233100008199 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1233100008200 active site 2 [active] 1233100008201 active site 1 [active] 1233100008202 Predicted permeases [General function prediction only]; Region: COG0730 1233100008203 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1233100008204 amidohydrolase; Region: amidohydrolases; TIGR01891 1233100008205 metal binding site [ion binding]; metal-binding site 1233100008206 dimer interface [polypeptide binding]; other site 1233100008207 Riboflavin kinase; Region: Flavokinase; pfam01687 1233100008208 Riboflavin kinase; Region: Flavokinase; cl03312 1233100008209 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1233100008210 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1233100008211 active site 1233100008212 non-prolyl cis peptide bond; other site 1233100008213 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1233100008214 catalytic residues [active] 1233100008215 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1233100008216 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1233100008217 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1233100008218 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1233100008219 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1233100008220 Walker A/P-loop; other site 1233100008221 ATP binding site [chemical binding]; other site 1233100008222 Q-loop/lid; other site 1233100008223 ABC transporter signature motif; other site 1233100008224 Walker B; other site 1233100008225 D-loop; other site 1233100008226 H-loop/switch region; other site 1233100008227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100008228 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1233100008229 dimer interface [polypeptide binding]; other site 1233100008230 conserved gate region; other site 1233100008231 putative PBP binding loops; other site 1233100008232 ABC-ATPase subunit interface; other site 1233100008233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100008234 dimer interface [polypeptide binding]; other site 1233100008235 conserved gate region; other site 1233100008236 putative PBP binding loops; other site 1233100008237 ABC-ATPase subunit interface; other site 1233100008238 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1233100008239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233100008240 substrate binding pocket [chemical binding]; other site 1233100008241 membrane-bound complex binding site; other site 1233100008242 hinge residues; other site 1233100008243 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1233100008244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233100008245 substrate binding pocket [chemical binding]; other site 1233100008246 membrane-bound complex binding site; other site 1233100008247 hinge residues; other site 1233100008248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1233100008249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100008250 Coenzyme A binding pocket [chemical binding]; other site 1233100008251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100008252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100008253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233100008254 dimerization interface [polypeptide binding]; other site 1233100008255 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1233100008256 metal-dependent hydrolase; Provisional; Region: PRK00685 1233100008257 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1233100008258 classical (c) SDRs; Region: SDR_c; cd05233 1233100008259 NAD(P) binding site [chemical binding]; other site 1233100008260 active site 1233100008261 argininosuccinate lyase; Provisional; Region: PRK00855 1233100008262 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1233100008263 active sites [active] 1233100008264 tetramer interface [polypeptide binding]; other site 1233100008265 argininosuccinate synthase; Provisional; Region: PRK13820 1233100008266 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1233100008267 ANP binding site [chemical binding]; other site 1233100008268 Substrate Binding Site II [chemical binding]; other site 1233100008269 Substrate Binding Site I [chemical binding]; other site 1233100008270 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1233100008271 MPT binding site; other site 1233100008272 trimer interface [polypeptide binding]; other site 1233100008273 propionate/acetate kinase; Provisional; Region: PRK12379 1233100008274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1233100008275 nucleotide binding site [chemical binding]; other site 1233100008276 butyrate kinase; Provisional; Region: PRK03011 1233100008277 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1233100008278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100008279 S-adenosylmethionine binding site [chemical binding]; other site 1233100008280 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1233100008281 dimer interface [polypeptide binding]; other site 1233100008282 catalytic triad [active] 1233100008283 peroxidatic and resolving cysteines [active] 1233100008284 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1233100008285 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1233100008286 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1233100008287 tandem repeat interface [polypeptide binding]; other site 1233100008288 oligomer interface [polypeptide binding]; other site 1233100008289 active site residues [active] 1233100008290 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1233100008291 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1233100008292 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1233100008293 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1233100008294 active site 1233100008295 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1233100008296 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1233100008297 active site 1233100008298 acyl-activating enzyme (AAE) consensus motif; other site 1233100008299 putative CoA binding site [chemical binding]; other site 1233100008300 AMP binding site [chemical binding]; other site 1233100008301 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1233100008302 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1233100008303 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1233100008304 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1233100008305 Ligand Binding Site [chemical binding]; other site 1233100008306 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1233100008307 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1233100008308 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233100008309 catalytic residue [active] 1233100008310 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1233100008311 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1233100008312 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1233100008313 oligomer interface [polypeptide binding]; other site 1233100008314 TMPIT-like protein; Region: TMPIT; pfam07851 1233100008315 histidinol-phosphatase; Reviewed; Region: PRK08123 1233100008316 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1233100008317 active site 1233100008318 dimer interface [polypeptide binding]; other site 1233100008319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100008320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100008321 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1233100008322 GAF domain; Region: GAF_2; pfam13185 1233100008323 GAF domain; Region: GAF; cl17456 1233100008324 GAF domain; Region: GAF; cl17456 1233100008325 GAF domain; Region: GAF_2; pfam13185 1233100008326 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1233100008327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1233100008328 metal binding site [ion binding]; metal-binding site 1233100008329 active site 1233100008330 I-site; other site 1233100008331 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1233100008332 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1233100008333 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1233100008334 active site 1233100008335 HIGH motif; other site 1233100008336 dimer interface [polypeptide binding]; other site 1233100008337 KMSKS motif; other site 1233100008338 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233100008339 RNA binding surface [nucleotide binding]; other site 1233100008340 acetyl-CoA synthetase; Provisional; Region: PRK04319 1233100008341 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1233100008342 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1233100008343 active site 1233100008344 acyl-activating enzyme (AAE) consensus motif; other site 1233100008345 putative CoA binding site [chemical binding]; other site 1233100008346 AMP binding site [chemical binding]; other site 1233100008347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100008348 Coenzyme A binding pocket [chemical binding]; other site 1233100008349 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1233100008350 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1233100008351 active site 1233100008352 Zn binding site [ion binding]; other site 1233100008353 flagellar motor protein MotS; Reviewed; Region: PRK06925 1233100008354 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1233100008355 ligand binding site [chemical binding]; other site 1233100008356 flagellar motor protein MotP; Reviewed; Region: PRK06926 1233100008357 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1233100008358 catabolite control protein A; Region: ccpA; TIGR01481 1233100008359 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100008360 DNA binding site [nucleotide binding] 1233100008361 domain linker motif; other site 1233100008362 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1233100008363 dimerization interface [polypeptide binding]; other site 1233100008364 effector binding site; other site 1233100008365 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1233100008366 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 1233100008367 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1233100008368 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233100008369 catalytic residues [active] 1233100008370 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1233100008371 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1233100008372 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1233100008373 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1233100008374 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233100008375 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1233100008376 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1233100008377 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1233100008378 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1233100008379 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1233100008380 putative tRNA-binding site [nucleotide binding]; other site 1233100008381 hypothetical protein; Provisional; Region: PRK13668 1233100008382 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233100008383 catalytic residues [active] 1233100008384 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1233100008385 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1233100008386 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1233100008387 oligomer interface [polypeptide binding]; other site 1233100008388 active site 1233100008389 metal binding site [ion binding]; metal-binding site 1233100008390 Predicted small secreted protein [Function unknown]; Region: COG5584 1233100008391 malate dehydrogenase; Provisional; Region: PRK13529 1233100008392 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1233100008393 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1233100008394 NAD(P) binding site [chemical binding]; other site 1233100008395 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1233100008396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100008397 S-adenosylmethionine binding site [chemical binding]; other site 1233100008398 YtzH-like protein; Region: YtzH; pfam14165 1233100008399 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1233100008400 active site 1233100008401 ATP binding site [chemical binding]; other site 1233100008402 Phosphotransferase enzyme family; Region: APH; pfam01636 1233100008403 substrate binding site [chemical binding]; other site 1233100008404 pullulanase, type I; Region: pulA_typeI; TIGR02104 1233100008405 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1233100008406 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1233100008407 Ca binding site [ion binding]; other site 1233100008408 active site 1233100008409 catalytic site [active] 1233100008410 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1233100008411 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1233100008412 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1233100008413 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1233100008414 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1233100008415 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1233100008416 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1233100008417 dimer interface [polypeptide binding]; other site 1233100008418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100008419 catalytic residue [active] 1233100008420 dipeptidase PepV; Reviewed; Region: PRK07318 1233100008421 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1233100008422 active site 1233100008423 metal binding site [ion binding]; metal-binding site 1233100008424 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1233100008425 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1233100008426 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1233100008427 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233100008428 Walker A/P-loop; other site 1233100008429 ATP binding site [chemical binding]; other site 1233100008430 Q-loop/lid; other site 1233100008431 ABC transporter signature motif; other site 1233100008432 Walker B; other site 1233100008433 D-loop; other site 1233100008434 H-loop/switch region; other site 1233100008435 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1233100008436 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1233100008437 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1233100008438 RNA binding surface [nucleotide binding]; other site 1233100008439 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1233100008440 active site 1233100008441 uracil binding [chemical binding]; other site 1233100008442 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1233100008443 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1233100008444 Predicted flavoproteins [General function prediction only]; Region: COG2081 1233100008445 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233100008446 BCCT family transporter; Region: BCCT; pfam02028 1233100008447 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1233100008448 Predicted integral membrane protein [Function unknown]; Region: COG5578 1233100008449 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233100008450 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233100008451 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233100008452 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1233100008453 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233100008454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100008455 dimer interface [polypeptide binding]; other site 1233100008456 conserved gate region; other site 1233100008457 ABC-ATPase subunit interface; other site 1233100008458 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1233100008459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100008460 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1233100008461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1233100008462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233100008463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233100008464 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233100008465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100008466 dimer interface [polypeptide binding]; other site 1233100008467 conserved gate region; other site 1233100008468 putative PBP binding loops; other site 1233100008469 ABC-ATPase subunit interface; other site 1233100008470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1233100008471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233100008472 NAD(P) binding site [chemical binding]; other site 1233100008473 active site 1233100008474 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1233100008475 Cytochrome P450; Region: p450; cl12078 1233100008476 biotin synthase; Validated; Region: PRK06256 1233100008477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100008478 FeS/SAM binding site; other site 1233100008479 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1233100008480 AAA domain; Region: AAA_26; pfam13500 1233100008481 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233100008482 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1233100008483 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1233100008484 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1233100008485 substrate-cofactor binding pocket; other site 1233100008486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100008487 catalytic residue [active] 1233100008488 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1233100008489 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233100008490 inhibitor-cofactor binding pocket; inhibition site 1233100008491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100008492 catalytic residue [active] 1233100008493 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1233100008494 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1233100008495 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1233100008496 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100008497 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100008498 DNA binding site [nucleotide binding] 1233100008499 domain linker motif; other site 1233100008500 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1233100008501 putative ligand binding site [chemical binding]; other site 1233100008502 putative dimerization interface [polypeptide binding]; other site 1233100008503 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233100008504 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1233100008505 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233100008506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100008507 dimer interface [polypeptide binding]; other site 1233100008508 conserved gate region; other site 1233100008509 putative PBP binding loops; other site 1233100008510 ABC-ATPase subunit interface; other site 1233100008511 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233100008512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100008513 dimer interface [polypeptide binding]; other site 1233100008514 conserved gate region; other site 1233100008515 putative PBP binding loops; other site 1233100008516 ABC-ATPase subunit interface; other site 1233100008517 alpha-galactosidase; Provisional; Region: PRK15076 1233100008518 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1233100008519 NAD binding site [chemical binding]; other site 1233100008520 sugar binding site [chemical binding]; other site 1233100008521 divalent metal binding site [ion binding]; other site 1233100008522 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233100008523 dimer interface [polypeptide binding]; other site 1233100008524 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1233100008525 active site residue [active] 1233100008526 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1233100008527 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1233100008528 HIGH motif; other site 1233100008529 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1233100008530 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1233100008531 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1233100008532 active site 1233100008533 KMSKS motif; other site 1233100008534 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1233100008535 tRNA binding surface [nucleotide binding]; other site 1233100008536 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1233100008537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100008538 PAS domain; Region: PAS_9; pfam13426 1233100008539 putative active site [active] 1233100008540 heme pocket [chemical binding]; other site 1233100008541 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1233100008542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100008543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100008544 putative substrate translocation pore; other site 1233100008545 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1233100008546 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1233100008547 FtsX-like permease family; Region: FtsX; pfam02687 1233100008548 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1233100008549 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1233100008550 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1233100008551 Walker A/P-loop; other site 1233100008552 ATP binding site [chemical binding]; other site 1233100008553 Q-loop/lid; other site 1233100008554 ABC transporter signature motif; other site 1233100008555 Walker B; other site 1233100008556 D-loop; other site 1233100008557 H-loop/switch region; other site 1233100008558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100008559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100008560 ATP binding site [chemical binding]; other site 1233100008561 Mg2+ binding site [ion binding]; other site 1233100008562 G-X-G motif; other site 1233100008563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100008564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100008565 active site 1233100008566 phosphorylation site [posttranslational modification] 1233100008567 intermolecular recognition site; other site 1233100008568 dimerization interface [polypeptide binding]; other site 1233100008569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100008570 DNA binding site [nucleotide binding] 1233100008571 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1233100008572 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1233100008573 FtsX-like permease family; Region: FtsX; pfam02687 1233100008574 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1233100008575 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1233100008576 Walker A/P-loop; other site 1233100008577 ATP binding site [chemical binding]; other site 1233100008578 Q-loop/lid; other site 1233100008579 ABC transporter signature motif; other site 1233100008580 Walker B; other site 1233100008581 D-loop; other site 1233100008582 H-loop/switch region; other site 1233100008583 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1233100008584 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1233100008585 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1233100008586 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1233100008587 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233100008588 Walker A/P-loop; other site 1233100008589 ATP binding site [chemical binding]; other site 1233100008590 Q-loop/lid; other site 1233100008591 ABC transporter signature motif; other site 1233100008592 Walker B; other site 1233100008593 D-loop; other site 1233100008594 H-loop/switch region; other site 1233100008595 Predicted transcriptional regulators [Transcription]; Region: COG1725 1233100008596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100008597 DNA-binding site [nucleotide binding]; DNA binding site 1233100008598 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1233100008599 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1233100008600 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1233100008601 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1233100008602 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1233100008603 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1233100008604 PGAP1-like protein; Region: PGAP1; pfam07819 1233100008605 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1233100008606 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1233100008607 trimer interface [polypeptide binding]; other site 1233100008608 putative metal binding site [ion binding]; other site 1233100008609 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1233100008610 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1233100008611 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1233100008612 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1233100008613 active site 1233100008614 substrate-binding site [chemical binding]; other site 1233100008615 metal-binding site [ion binding] 1233100008616 ATP binding site [chemical binding]; other site 1233100008617 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1233100008618 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1233100008619 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1233100008620 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1233100008621 NMT1-like family; Region: NMT1_2; pfam13379 1233100008622 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1233100008623 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1233100008624 Walker A/P-loop; other site 1233100008625 ATP binding site [chemical binding]; other site 1233100008626 Q-loop/lid; other site 1233100008627 ABC transporter signature motif; other site 1233100008628 Walker B; other site 1233100008629 D-loop; other site 1233100008630 H-loop/switch region; other site 1233100008631 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1233100008632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100008633 dimer interface [polypeptide binding]; other site 1233100008634 conserved gate region; other site 1233100008635 putative PBP binding loops; other site 1233100008636 ABC-ATPase subunit interface; other site 1233100008637 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1233100008638 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1233100008639 nudix motif; other site 1233100008640 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1233100008641 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1233100008642 dimerization interface [polypeptide binding]; other site 1233100008643 DPS ferroxidase diiron center [ion binding]; other site 1233100008644 ion pore; other site 1233100008645 YtkA-like; Region: YtkA; pfam13115 1233100008646 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 1233100008647 Haemolytic domain; Region: Haemolytic; pfam01809 1233100008648 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1233100008649 active site clefts [active] 1233100008650 zinc binding site [ion binding]; other site 1233100008651 dimer interface [polypeptide binding]; other site 1233100008652 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1233100008653 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1233100008654 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1233100008655 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1233100008656 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100008657 ABC-ATPase subunit interface; other site 1233100008658 dimer interface [polypeptide binding]; other site 1233100008659 putative PBP binding regions; other site 1233100008660 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1233100008661 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100008662 ABC-ATPase subunit interface; other site 1233100008663 dimer interface [polypeptide binding]; other site 1233100008664 putative PBP binding regions; other site 1233100008665 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1233100008666 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1233100008667 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1233100008668 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1233100008669 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1233100008670 metal binding site [ion binding]; metal-binding site 1233100008671 intersubunit interface [polypeptide binding]; other site 1233100008672 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1233100008673 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1233100008674 active site 1233100008675 octamer interface [polypeptide binding]; other site 1233100008676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233100008677 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1233100008678 substrate binding site [chemical binding]; other site 1233100008679 oxyanion hole (OAH) forming residues; other site 1233100008680 trimer interface [polypeptide binding]; other site 1233100008681 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1233100008682 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1233100008683 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1233100008684 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1233100008685 dimer interface [polypeptide binding]; other site 1233100008686 tetramer interface [polypeptide binding]; other site 1233100008687 PYR/PP interface [polypeptide binding]; other site 1233100008688 TPP binding site [chemical binding]; other site 1233100008689 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1233100008690 TPP-binding site; other site 1233100008691 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1233100008692 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1233100008693 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1233100008694 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1233100008695 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1233100008696 active site 1233100008697 tetramer interface; other site 1233100008698 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1233100008699 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1233100008700 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1233100008701 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1233100008702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1233100008703 NAD(P) binding site [chemical binding]; other site 1233100008704 active site 1233100008705 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233100008706 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1233100008707 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1233100008708 spore coat protein YutH; Region: spore_yutH; TIGR02905 1233100008709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233100008710 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1233100008711 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1233100008712 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1233100008713 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1233100008714 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1233100008715 homodimer interface [polypeptide binding]; other site 1233100008716 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1233100008717 active site pocket [active] 1233100008718 glycogen synthase; Provisional; Region: glgA; PRK00654 1233100008719 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1233100008720 ADP-binding pocket [chemical binding]; other site 1233100008721 homodimer interface [polypeptide binding]; other site 1233100008722 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1233100008723 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1233100008724 ligand binding site; other site 1233100008725 oligomer interface; other site 1233100008726 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1233100008727 dimer interface [polypeptide binding]; other site 1233100008728 N-terminal domain interface [polypeptide binding]; other site 1233100008729 sulfate 1 binding site; other site 1233100008730 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 1233100008731 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1233100008732 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1233100008733 active site 1233100008734 catalytic site [active] 1233100008735 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1233100008736 Predicted membrane protein [Function unknown]; Region: COG3859 1233100008737 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1233100008738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1233100008739 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1233100008740 DinB superfamily; Region: DinB_2; pfam12867 1233100008741 metal-dependent hydrolase; Provisional; Region: PRK13291 1233100008742 MOSC domain; Region: MOSC; pfam03473 1233100008743 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1233100008744 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1233100008745 active site 1233100008746 NAD binding site [chemical binding]; other site 1233100008747 metal binding site [ion binding]; metal-binding site 1233100008748 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1233100008749 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1233100008750 tetramerization interface [polypeptide binding]; other site 1233100008751 NAD(P) binding site [chemical binding]; other site 1233100008752 catalytic residues [active] 1233100008753 Predicted transcriptional regulators [Transcription]; Region: COG1510 1233100008754 MarR family; Region: MarR_2; pfam12802 1233100008755 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1233100008756 TrkA-N domain; Region: TrkA_N; pfam02254 1233100008757 TrkA-C domain; Region: TrkA_C; pfam02080 1233100008758 Predicted membrane protein [Function unknown]; Region: COG4682 1233100008759 yiaA/B two helix domain; Region: YiaAB; pfam05360 1233100008760 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1233100008761 SH3-like domain; Region: SH3_8; pfam13457 1233100008762 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100008763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100008764 putative substrate translocation pore; other site 1233100008765 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1233100008766 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1233100008767 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1233100008768 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1233100008769 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233100008770 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233100008771 L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134 1233100008772 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1233100008773 Domain of unknown function (DUF718); Region: DUF718; cl01281 1233100008774 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1233100008775 N- and C-terminal domain interface [polypeptide binding]; other site 1233100008776 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1233100008777 active site 1233100008778 putative catalytic site [active] 1233100008779 metal binding site [ion binding]; metal-binding site 1233100008780 ATP binding site [chemical binding]; other site 1233100008781 carbohydrate binding site [chemical binding]; other site 1233100008782 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1233100008783 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1233100008784 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1233100008785 short chain dehydrogenase; Validated; Region: PRK08324 1233100008786 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1233100008787 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1233100008788 putative NAD(P) binding site [chemical binding]; other site 1233100008789 active site 1233100008790 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1233100008791 Cache domain; Region: Cache_1; pfam02743 1233100008792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100008793 dimerization interface [polypeptide binding]; other site 1233100008794 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233100008795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100008796 dimer interface [polypeptide binding]; other site 1233100008797 putative CheW interface [polypeptide binding]; other site 1233100008798 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100008799 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1233100008800 Cache domain; Region: Cache_1; pfam02743 1233100008801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100008802 dimerization interface [polypeptide binding]; other site 1233100008803 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100008804 dimer interface [polypeptide binding]; other site 1233100008805 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1233100008806 putative CheW interface [polypeptide binding]; other site 1233100008807 Tar ligand binding domain homologue; Region: TarH; pfam02203 1233100008808 Cache domain; Region: Cache_1; pfam02743 1233100008809 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1233100008810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100008811 dimerization interface [polypeptide binding]; other site 1233100008812 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100008813 dimer interface [polypeptide binding]; other site 1233100008814 putative CheW interface [polypeptide binding]; other site 1233100008815 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1233100008816 Cache domain; Region: Cache_1; pfam02743 1233100008817 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100008818 dimerization interface [polypeptide binding]; other site 1233100008819 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1233100008820 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100008821 dimer interface [polypeptide binding]; other site 1233100008822 putative CheW interface [polypeptide binding]; other site 1233100008823 transglutaminase; Provisional; Region: tgl; PRK03187 1233100008824 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1233100008825 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1233100008826 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1233100008827 Ca binding site [ion binding]; other site 1233100008828 active site 1233100008829 catalytic site [active] 1233100008830 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1233100008831 Domain of unknown function DUF21; Region: DUF21; pfam01595 1233100008832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1233100008833 Transporter associated domain; Region: CorC_HlyC; smart01091 1233100008834 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1233100008835 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1233100008836 Ion channel; Region: Ion_trans_2; pfam07885 1233100008837 TrkA-N domain; Region: TrkA_N; pfam02254 1233100008838 YugN-like family; Region: YugN; pfam08868 1233100008839 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1233100008840 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1233100008841 active site 1233100008842 dimer interface [polypeptide binding]; other site 1233100008843 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1233100008844 dimer interface [polypeptide binding]; other site 1233100008845 active site 1233100008846 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1233100008847 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1233100008848 dimer interface [polypeptide binding]; other site 1233100008849 active site 1233100008850 metal binding site [ion binding]; metal-binding site 1233100008851 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1233100008852 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1233100008853 dimer interface [polypeptide binding]; other site 1233100008854 active site 1233100008855 metal binding site [ion binding]; metal-binding site 1233100008856 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1233100008857 general stress protein 13; Validated; Region: PRK08059 1233100008858 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1233100008859 RNA binding site [nucleotide binding]; other site 1233100008860 hypothetical protein; Validated; Region: PRK07682 1233100008861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100008862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100008863 homodimer interface [polypeptide binding]; other site 1233100008864 catalytic residue [active] 1233100008865 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1233100008866 AsnC family; Region: AsnC_trans_reg; pfam01037 1233100008867 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100008868 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1233100008869 nucleophilic elbow; other site 1233100008870 catalytic triad; other site 1233100008871 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1233100008872 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1233100008873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100008874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100008875 homodimer interface [polypeptide binding]; other site 1233100008876 catalytic residue [active] 1233100008877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100008878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100008879 dimer interface [polypeptide binding]; other site 1233100008880 phosphorylation site [posttranslational modification] 1233100008881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100008882 ATP binding site [chemical binding]; other site 1233100008883 Mg2+ binding site [ion binding]; other site 1233100008884 G-X-G motif; other site 1233100008885 Kinase associated protein B; Region: KapB; pfam08810 1233100008886 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1233100008887 active site 1233100008888 catalytic site [active] 1233100008889 substrate binding site [chemical binding]; other site 1233100008890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100008891 drug efflux system protein MdtG; Provisional; Region: PRK09874 1233100008892 putative substrate translocation pore; other site 1233100008893 Transglycosylase; Region: Transgly; pfam00912 1233100008894 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1233100008895 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1233100008896 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1233100008897 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1233100008898 PAS domain; Region: PAS; smart00091 1233100008899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100008900 ATP binding site [chemical binding]; other site 1233100008901 G-X-G motif; other site 1233100008902 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1233100008903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100008904 active site 1233100008905 phosphorylation site [posttranslational modification] 1233100008906 intermolecular recognition site; other site 1233100008907 dimerization interface [polypeptide binding]; other site 1233100008908 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1233100008909 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1233100008910 ligand binding site [chemical binding]; other site 1233100008911 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1233100008912 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1233100008913 Walker A/P-loop; other site 1233100008914 ATP binding site [chemical binding]; other site 1233100008915 Q-loop/lid; other site 1233100008916 ABC transporter signature motif; other site 1233100008917 Walker B; other site 1233100008918 D-loop; other site 1233100008919 H-loop/switch region; other site 1233100008920 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1233100008921 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233100008922 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1233100008923 TM-ABC transporter signature motif; other site 1233100008924 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1233100008925 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1233100008926 TM-ABC transporter signature motif; other site 1233100008927 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1233100008928 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1233100008929 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1233100008930 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1233100008931 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1233100008932 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1233100008933 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1233100008934 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1233100008935 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1233100008936 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1233100008937 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1233100008938 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1233100008939 CoenzymeA binding site [chemical binding]; other site 1233100008940 subunit interaction site [polypeptide binding]; other site 1233100008941 PHB binding site; other site 1233100008942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1233100008943 Histidine kinase; Region: HisKA_3; pfam07730 1233100008944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100008945 ATP binding site [chemical binding]; other site 1233100008946 Mg2+ binding site [ion binding]; other site 1233100008947 G-X-G motif; other site 1233100008948 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1233100008949 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1233100008950 substrate binding pocket [chemical binding]; other site 1233100008951 substrate-Mg2+ binding site; other site 1233100008952 aspartate-rich region 1; other site 1233100008953 aspartate-rich region 2; other site 1233100008954 DegQ (SacQ) family; Region: DegQ; pfam08181 1233100008955 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1233100008956 EAL domain; Region: EAL; pfam00563 1233100008957 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1233100008958 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1233100008959 active site 1233100008960 Isochorismatase family; Region: Isochorismatase; pfam00857 1233100008961 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1233100008962 catalytic triad [active] 1233100008963 conserved cis-peptide bond; other site 1233100008964 Uncharacterized conserved protein [Function unknown]; Region: COG5506 1233100008965 YueH-like protein; Region: YueH; pfam14166 1233100008966 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1233100008967 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1233100008968 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1233100008969 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 1233100008970 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1233100008971 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233100008972 Zn2+ binding site [ion binding]; other site 1233100008973 Mg2+ binding site [ion binding]; other site 1233100008974 short chain dehydrogenase; Provisional; Region: PRK06924 1233100008975 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1233100008976 NADP binding site [chemical binding]; other site 1233100008977 homodimer interface [polypeptide binding]; other site 1233100008978 active site 1233100008979 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1233100008980 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1233100008981 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1233100008982 Predicted membrane protein [Function unknown]; Region: COG1511 1233100008983 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1233100008984 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1233100008985 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1233100008986 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1233100008987 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1233100008988 Domain of unknown function DUF87; Region: DUF87; pfam01935 1233100008989 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1233100008990 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1233100008991 Uncharacterized small protein [Function unknown]; Region: COG5417 1233100008992 Ubiquitin homologues; Region: UBQ; smart00213 1233100008993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1233100008994 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1233100008995 CodY GAF-like domain; Region: CodY; pfam06018 1233100008996 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233100008997 alanine dehydrogenase; Region: alaDH; TIGR00518 1233100008998 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1233100008999 hexamer interface [polypeptide binding]; other site 1233100009000 ligand binding site [chemical binding]; other site 1233100009001 putative active site [active] 1233100009002 NAD(P) binding site [chemical binding]; other site 1233100009003 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1233100009004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1233100009005 Condensation domain; Region: Condensation; pfam00668 1233100009006 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1233100009007 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1233100009008 acyl-activating enzyme (AAE) consensus motif; other site 1233100009009 AMP binding site [chemical binding]; other site 1233100009010 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100009011 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1233100009012 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1233100009013 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1233100009014 acyl-activating enzyme (AAE) consensus motif; other site 1233100009015 AMP binding site [chemical binding]; other site 1233100009016 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1233100009017 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1233100009018 hydrophobic substrate binding pocket; other site 1233100009019 Isochorismatase family; Region: Isochorismatase; pfam00857 1233100009020 active site 1233100009021 conserved cis-peptide bond; other site 1233100009022 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1233100009023 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1233100009024 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1233100009025 acyl-activating enzyme (AAE) consensus motif; other site 1233100009026 active site 1233100009027 AMP binding site [chemical binding]; other site 1233100009028 substrate binding site [chemical binding]; other site 1233100009029 isochorismate synthase DhbC; Validated; Region: PRK06923 1233100009030 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1233100009031 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1233100009032 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1233100009033 putative NAD(P) binding site [chemical binding]; other site 1233100009034 active site 1233100009035 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1233100009036 Putative esterase; Region: Esterase; pfam00756 1233100009037 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1233100009038 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1233100009039 Moco binding site; other site 1233100009040 metal coordination site [ion binding]; other site 1233100009041 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1233100009042 Predicted permease [General function prediction only]; Region: COG2056 1233100009043 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1233100009044 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1233100009045 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1233100009046 interface (dimer of trimers) [polypeptide binding]; other site 1233100009047 Substrate-binding/catalytic site; other site 1233100009048 Zn-binding sites [ion binding]; other site 1233100009049 Divergent PAP2 family; Region: DUF212; pfam02681 1233100009050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1233100009051 Putative membrane protein; Region: YuiB; pfam14068 1233100009052 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1233100009053 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1233100009054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100009055 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1233100009056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233100009057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100009058 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1233100009059 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1233100009060 active site 1233100009061 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1233100009062 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1233100009063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100009064 Coenzyme A binding pocket [chemical binding]; other site 1233100009065 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1233100009066 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1233100009067 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1233100009068 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1233100009069 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1233100009070 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1233100009071 Nucleoside recognition; Region: Gate; pfam07670 1233100009072 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1233100009073 hypothetical protein; Provisional; Region: PRK13669 1233100009074 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1233100009075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100009076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1233100009077 NifU-like domain; Region: NifU; pfam01106 1233100009078 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1233100009079 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1233100009080 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1233100009081 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1233100009082 homoserine kinase; Region: thrB; TIGR00191 1233100009083 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1233100009084 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1233100009085 threonine synthase; Reviewed; Region: PRK06721 1233100009086 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1233100009087 homodimer interface [polypeptide binding]; other site 1233100009088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100009089 catalytic residue [active] 1233100009090 homoserine dehydrogenase; Provisional; Region: PRK06349 1233100009091 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1233100009092 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1233100009093 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1233100009094 spore coat protein YutH; Region: spore_yutH; TIGR02905 1233100009095 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1233100009096 tetramer interfaces [polypeptide binding]; other site 1233100009097 binuclear metal-binding site [ion binding]; other site 1233100009098 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1233100009099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100009100 active site 1233100009101 motif I; other site 1233100009102 motif II; other site 1233100009103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100009104 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1233100009105 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1233100009106 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1233100009107 lipoyl synthase; Provisional; Region: PRK05481 1233100009108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100009109 FeS/SAM binding site; other site 1233100009110 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1233100009111 Peptidase family M23; Region: Peptidase_M23; pfam01551 1233100009112 sporulation protein YunB; Region: spo_yunB; TIGR02832 1233100009113 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1233100009114 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1233100009115 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1233100009116 active site 1233100009117 metal binding site [ion binding]; metal-binding site 1233100009118 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1233100009119 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1233100009120 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1233100009121 allantoinase; Provisional; Region: PRK06189 1233100009122 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1233100009123 active site 1233100009124 DRTGG domain; Region: DRTGG; pfam07085 1233100009125 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1233100009126 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233100009127 xanthine permease; Region: pbuX; TIGR03173 1233100009128 xanthine permease; Region: pbuX; TIGR03173 1233100009129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1233100009130 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1233100009131 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1233100009132 active site 1233100009133 Transthyretin-like protein [General function prediction only]; Region: COG2351 1233100009134 active site 1233100009135 homotetramer interface [polypeptide binding]; other site 1233100009136 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1233100009137 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1233100009138 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1233100009139 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1233100009140 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1233100009141 Ligand binding site; other site 1233100009142 metal-binding site 1233100009143 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1233100009144 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1233100009145 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1233100009146 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1233100009147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233100009148 catalytic residue [active] 1233100009149 allantoate amidohydrolase; Reviewed; Region: PRK09290 1233100009150 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1233100009151 active site 1233100009152 metal binding site [ion binding]; metal-binding site 1233100009153 dimer interface [polypeptide binding]; other site 1233100009154 Endonuclease I; Region: Endonuclease_1; cl01003 1233100009155 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1233100009156 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1233100009157 Walker A/P-loop; other site 1233100009158 ATP binding site [chemical binding]; other site 1233100009159 Q-loop/lid; other site 1233100009160 ABC transporter signature motif; other site 1233100009161 Walker B; other site 1233100009162 D-loop; other site 1233100009163 H-loop/switch region; other site 1233100009164 TOBE domain; Region: TOBE_2; pfam08402 1233100009165 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1233100009166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100009167 DNA-binding site [nucleotide binding]; DNA binding site 1233100009168 UTRA domain; Region: UTRA; pfam07702 1233100009169 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1233100009170 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1233100009171 substrate binding site [chemical binding]; other site 1233100009172 ATP binding site [chemical binding]; other site 1233100009173 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233100009174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009175 dimer interface [polypeptide binding]; other site 1233100009176 conserved gate region; other site 1233100009177 putative PBP binding loops; other site 1233100009178 ABC-ATPase subunit interface; other site 1233100009179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009180 dimer interface [polypeptide binding]; other site 1233100009181 conserved gate region; other site 1233100009182 putative PBP binding loops; other site 1233100009183 ABC-ATPase subunit interface; other site 1233100009184 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1233100009185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233100009186 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1233100009187 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1233100009188 putative active site [active] 1233100009189 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1233100009190 dimer interface [polypeptide binding]; other site 1233100009191 active site 1233100009192 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1233100009193 GIY-YIG motif/motif A; other site 1233100009194 active site 1233100009195 catalytic site [active] 1233100009196 putative DNA binding site [nucleotide binding]; other site 1233100009197 metal binding site [ion binding]; metal-binding site 1233100009198 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1233100009199 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1233100009200 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1233100009201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100009202 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1233100009203 FeS assembly protein SufB; Region: sufB; TIGR01980 1233100009204 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1233100009205 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1233100009206 trimerization site [polypeptide binding]; other site 1233100009207 active site 1233100009208 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1233100009209 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1233100009210 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233100009211 catalytic residue [active] 1233100009212 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1233100009213 FeS assembly protein SufD; Region: sufD; TIGR01981 1233100009214 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1233100009215 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1233100009216 Walker A/P-loop; other site 1233100009217 ATP binding site [chemical binding]; other site 1233100009218 Q-loop/lid; other site 1233100009219 ABC transporter signature motif; other site 1233100009220 Walker B; other site 1233100009221 D-loop; other site 1233100009222 H-loop/switch region; other site 1233100009223 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1233100009224 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1233100009225 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1233100009226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009227 conserved gate region; other site 1233100009228 ABC-ATPase subunit interface; other site 1233100009229 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1233100009230 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1233100009231 Walker A/P-loop; other site 1233100009232 ATP binding site [chemical binding]; other site 1233100009233 Q-loop/lid; other site 1233100009234 ABC transporter signature motif; other site 1233100009235 Walker B; other site 1233100009236 D-loop; other site 1233100009237 H-loop/switch region; other site 1233100009238 NIL domain; Region: NIL; pfam09383 1233100009239 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1233100009240 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1233100009241 catalytic residues [active] 1233100009242 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1233100009243 putative active site [active] 1233100009244 putative metal binding site [ion binding]; other site 1233100009245 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1233100009246 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1233100009247 lipoyl attachment site [posttranslational modification]; other site 1233100009248 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1233100009249 ArsC family; Region: ArsC; pfam03960 1233100009250 putative ArsC-like catalytic residues; other site 1233100009251 putative TRX-like catalytic residues [active] 1233100009252 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1233100009253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233100009254 active site 1233100009255 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1233100009256 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1233100009257 dimer interface [polypeptide binding]; other site 1233100009258 active site 1233100009259 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1233100009260 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1233100009261 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233100009262 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1233100009263 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1233100009264 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1233100009265 substrate binding site [chemical binding]; other site 1233100009266 oxyanion hole (OAH) forming residues; other site 1233100009267 trimer interface [polypeptide binding]; other site 1233100009268 Proline dehydrogenase; Region: Pro_dh; pfam01619 1233100009269 Coat F domain; Region: Coat_F; pfam07875 1233100009270 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100009271 MarR family; Region: MarR; pfam01047 1233100009272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100009273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100009274 putative substrate translocation pore; other site 1233100009275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100009276 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1233100009277 classical (c) SDRs; Region: SDR_c; cd05233 1233100009278 NAD(P) binding site [chemical binding]; other site 1233100009279 active site 1233100009280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100009281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100009282 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1233100009283 putative dimerization interface [polypeptide binding]; other site 1233100009284 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1233100009285 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1233100009286 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1233100009287 Walker A/P-loop; other site 1233100009288 ATP binding site [chemical binding]; other site 1233100009289 Q-loop/lid; other site 1233100009290 ABC transporter signature motif; other site 1233100009291 Walker B; other site 1233100009292 D-loop; other site 1233100009293 H-loop/switch region; other site 1233100009294 YusW-like protein; Region: YusW; pfam14039 1233100009295 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1233100009296 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1233100009297 active site 1233100009298 Zn binding site [ion binding]; other site 1233100009299 short chain dehydrogenase; Provisional; Region: PRK06914 1233100009300 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1233100009301 NADP binding site [chemical binding]; other site 1233100009302 active site 1233100009303 steroid binding site; other site 1233100009304 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1233100009305 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1233100009306 dimerization interface [polypeptide binding]; other site 1233100009307 DPS ferroxidase diiron center [ion binding]; other site 1233100009308 ion pore; other site 1233100009309 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1233100009310 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1233100009311 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1233100009312 protein binding site [polypeptide binding]; other site 1233100009313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100009314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100009315 active site 1233100009316 phosphorylation site [posttranslational modification] 1233100009317 intermolecular recognition site; other site 1233100009318 dimerization interface [polypeptide binding]; other site 1233100009319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100009320 DNA binding site [nucleotide binding] 1233100009321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100009322 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100009323 dimerization interface [polypeptide binding]; other site 1233100009324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100009325 dimer interface [polypeptide binding]; other site 1233100009326 phosphorylation site [posttranslational modification] 1233100009327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100009328 ATP binding site [chemical binding]; other site 1233100009329 Mg2+ binding site [ion binding]; other site 1233100009330 G-X-G motif; other site 1233100009331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100009332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100009333 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1233100009334 Class II fumarases; Region: Fumarase_classII; cd01362 1233100009335 active site 1233100009336 tetramer interface [polypeptide binding]; other site 1233100009337 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1233100009338 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233100009339 Spore germination protein; Region: Spore_permease; pfam03845 1233100009340 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1233100009341 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1233100009342 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233100009343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100009344 active site 1233100009345 phosphorylation site [posttranslational modification] 1233100009346 intermolecular recognition site; other site 1233100009347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233100009348 DNA binding residues [nucleotide binding] 1233100009349 dimerization interface [polypeptide binding]; other site 1233100009350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1233100009351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100009352 dimerization interface [polypeptide binding]; other site 1233100009353 Histidine kinase; Region: HisKA_3; pfam07730 1233100009354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100009355 ATP binding site [chemical binding]; other site 1233100009356 Mg2+ binding site [ion binding]; other site 1233100009357 G-X-G motif; other site 1233100009358 Predicted membrane protein [Function unknown]; Region: COG4758 1233100009359 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1233100009360 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1233100009361 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1233100009362 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1233100009363 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1233100009364 PspA/IM30 family; Region: PspA_IM30; pfam04012 1233100009365 H+ Antiporter protein; Region: 2A0121; TIGR00900 1233100009366 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 1233100009367 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1233100009368 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1233100009369 Walker A/P-loop; other site 1233100009370 ATP binding site [chemical binding]; other site 1233100009371 Q-loop/lid; other site 1233100009372 ABC transporter signature motif; other site 1233100009373 Walker B; other site 1233100009374 D-loop; other site 1233100009375 H-loop/switch region; other site 1233100009376 Adenosylcobinamide amidohydrolase [Coenzyme metabolism]; Region: cbiZ; COG1865 1233100009377 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233100009378 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100009379 ABC-ATPase subunit interface; other site 1233100009380 dimer interface [polypeptide binding]; other site 1233100009381 putative PBP binding regions; other site 1233100009382 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1233100009383 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1233100009384 putative binding site residues; other site 1233100009385 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1233100009386 classical (c) SDRs; Region: SDR_c; cd05233 1233100009387 NAD(P) binding site [chemical binding]; other site 1233100009388 active site 1233100009389 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1233100009390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100009391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100009392 dimer interface [polypeptide binding]; other site 1233100009393 phosphorylation site [posttranslational modification] 1233100009394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100009395 ATP binding site [chemical binding]; other site 1233100009396 Mg2+ binding site [ion binding]; other site 1233100009397 G-X-G motif; other site 1233100009398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100009399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100009400 active site 1233100009401 phosphorylation site [posttranslational modification] 1233100009402 intermolecular recognition site; other site 1233100009403 dimerization interface [polypeptide binding]; other site 1233100009404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100009405 DNA binding site [nucleotide binding] 1233100009406 hypothetical protein; Provisional; Region: PRK14082 1233100009407 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1233100009408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100009409 DNA binding residues [nucleotide binding] 1233100009410 YvrJ protein family; Region: YvrJ; pfam12841 1233100009411 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1233100009412 Cupin; Region: Cupin_1; smart00835 1233100009413 Cupin; Region: Cupin_1; smart00835 1233100009414 Regulatory protein YrvL; Region: YrvL; pfam14184 1233100009415 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1233100009416 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1233100009417 FtsX-like permease family; Region: FtsX; pfam02687 1233100009418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1233100009419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1233100009420 Walker A/P-loop; other site 1233100009421 ATP binding site [chemical binding]; other site 1233100009422 Q-loop/lid; other site 1233100009423 ABC transporter signature motif; other site 1233100009424 Walker B; other site 1233100009425 D-loop; other site 1233100009426 H-loop/switch region; other site 1233100009427 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1233100009428 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1233100009429 HlyD family secretion protein; Region: HlyD_3; pfam13437 1233100009430 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1233100009431 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1233100009432 Walker A/P-loop; other site 1233100009433 ATP binding site [chemical binding]; other site 1233100009434 Q-loop/lid; other site 1233100009435 ABC transporter signature motif; other site 1233100009436 Walker B; other site 1233100009437 D-loop; other site 1233100009438 H-loop/switch region; other site 1233100009439 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1233100009440 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1233100009441 ABC-ATPase subunit interface; other site 1233100009442 dimer interface [polypeptide binding]; other site 1233100009443 putative PBP binding regions; other site 1233100009444 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1233100009445 putative ligand binding residues [chemical binding]; other site 1233100009446 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1233100009447 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1233100009448 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 1233100009449 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1233100009450 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1233100009451 Sulfatase; Region: Sulfatase; pfam00884 1233100009452 DNA binding domain, excisionase family; Region: excise; TIGR01764 1233100009453 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1233100009454 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1233100009455 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1233100009456 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1233100009457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009458 dimer interface [polypeptide binding]; other site 1233100009459 conserved gate region; other site 1233100009460 putative PBP binding loops; other site 1233100009461 ABC-ATPase subunit interface; other site 1233100009462 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233100009463 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233100009464 active site 1233100009465 catalytic tetrad [active] 1233100009466 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1233100009467 sulfite reductase subunit beta; Provisional; Region: PRK13504 1233100009468 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1233100009469 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1233100009470 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1233100009471 Flavodoxin; Region: Flavodoxin_1; pfam00258 1233100009472 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1233100009473 FAD binding pocket [chemical binding]; other site 1233100009474 FAD binding motif [chemical binding]; other site 1233100009475 catalytic residues [active] 1233100009476 NAD binding pocket [chemical binding]; other site 1233100009477 phosphate binding motif [ion binding]; other site 1233100009478 beta-alpha-beta structure motif; other site 1233100009479 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1233100009480 Part of AAA domain; Region: AAA_19; pfam13245 1233100009481 Family description; Region: UvrD_C_2; pfam13538 1233100009482 Predicted membrane protein [Function unknown]; Region: COG2860 1233100009483 UPF0126 domain; Region: UPF0126; pfam03458 1233100009484 UPF0126 domain; Region: UPF0126; pfam03458 1233100009485 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1233100009486 Thioredoxin; Region: Thioredoxin_4; pfam13462 1233100009487 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1233100009488 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1233100009489 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233100009490 metal-binding site [ion binding] 1233100009491 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1233100009492 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1233100009493 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1233100009494 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233100009495 metal-binding site [ion binding] 1233100009496 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1233100009497 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233100009498 metal-binding site [ion binding] 1233100009499 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1233100009500 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1233100009501 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1233100009502 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1233100009503 metal-binding site [ion binding] 1233100009504 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1233100009505 putative homodimer interface [polypeptide binding]; other site 1233100009506 putative homotetramer interface [polypeptide binding]; other site 1233100009507 allosteric switch controlling residues; other site 1233100009508 putative metal binding site [ion binding]; other site 1233100009509 putative homodimer-homodimer interface [polypeptide binding]; other site 1233100009510 putative oxidoreductase; Provisional; Region: PRK11579 1233100009511 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233100009512 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233100009513 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1233100009514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100009515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100009516 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1233100009517 classical (c) SDRs; Region: SDR_c; cd05233 1233100009518 NAD(P) binding site [chemical binding]; other site 1233100009519 active site 1233100009520 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1233100009521 SmpB-tmRNA interface; other site 1233100009522 ribonuclease R; Region: RNase_R; TIGR02063 1233100009523 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1233100009524 Cold shock protein domain; Region: CSP; smart00357 1233100009525 RNB domain; Region: RNB; pfam00773 1233100009526 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1233100009527 RNA binding site [nucleotide binding]; other site 1233100009528 Esterase/lipase [General function prediction only]; Region: COG1647 1233100009529 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1233100009530 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100009531 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1233100009532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100009533 sequence-specific DNA binding site [nucleotide binding]; other site 1233100009534 salt bridge; other site 1233100009535 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233100009536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100009537 non-specific DNA binding site [nucleotide binding]; other site 1233100009538 salt bridge; other site 1233100009539 sequence-specific DNA binding site [nucleotide binding]; other site 1233100009540 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233100009541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100009542 non-specific DNA binding site [nucleotide binding]; other site 1233100009543 salt bridge; other site 1233100009544 sequence-specific DNA binding site [nucleotide binding]; other site 1233100009545 Predicted transcriptional regulators [Transcription]; Region: COG1733 1233100009546 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100009547 dimerization interface [polypeptide binding]; other site 1233100009548 putative DNA binding site [nucleotide binding]; other site 1233100009549 putative Zn2+ binding site [ion binding]; other site 1233100009550 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1233100009551 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1233100009552 active site 1233100009553 catalytic residues [active] 1233100009554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009555 dimer interface [polypeptide binding]; other site 1233100009556 conserved gate region; other site 1233100009557 putative PBP binding loops; other site 1233100009558 ABC-ATPase subunit interface; other site 1233100009559 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1233100009560 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1233100009561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009562 dimer interface [polypeptide binding]; other site 1233100009563 conserved gate region; other site 1233100009564 putative PBP binding loops; other site 1233100009565 ABC-ATPase subunit interface; other site 1233100009566 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1233100009567 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1233100009568 Walker A/P-loop; other site 1233100009569 ATP binding site [chemical binding]; other site 1233100009570 Q-loop/lid; other site 1233100009571 ABC transporter signature motif; other site 1233100009572 Walker B; other site 1233100009573 D-loop; other site 1233100009574 H-loop/switch region; other site 1233100009575 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1233100009576 Predicted transcriptional regulators [Transcription]; Region: COG1510 1233100009577 MarR family; Region: MarR_2; pfam12802 1233100009578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009579 dimer interface [polypeptide binding]; other site 1233100009580 conserved gate region; other site 1233100009581 putative PBP binding loops; other site 1233100009582 ABC-ATPase subunit interface; other site 1233100009583 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1233100009584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009585 dimer interface [polypeptide binding]; other site 1233100009586 conserved gate region; other site 1233100009587 putative PBP binding loops; other site 1233100009588 ABC-ATPase subunit interface; other site 1233100009589 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1233100009590 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1233100009591 Walker A/P-loop; other site 1233100009592 ATP binding site [chemical binding]; other site 1233100009593 Q-loop/lid; other site 1233100009594 ABC transporter signature motif; other site 1233100009595 Walker B; other site 1233100009596 D-loop; other site 1233100009597 H-loop/switch region; other site 1233100009598 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1233100009599 membrane protein, MarC family; Region: TIGR00427 1233100009600 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1233100009601 pentamer interface [polypeptide binding]; other site 1233100009602 dodecaamer interface [polypeptide binding]; other site 1233100009603 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1233100009604 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1233100009605 Double zinc ribbon; Region: DZR; pfam12773 1233100009606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1233100009607 Predicted membrane protein [Function unknown]; Region: COG4640 1233100009608 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1233100009609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100009610 Coenzyme A binding pocket [chemical binding]; other site 1233100009611 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1233100009612 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1233100009613 WbqC-like protein family; Region: WbqC; pfam08889 1233100009614 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1233100009615 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1233100009616 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1233100009617 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1233100009618 catalytic residue [active] 1233100009619 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1233100009620 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1233100009621 enolase; Provisional; Region: eno; PRK00077 1233100009622 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1233100009623 dimer interface [polypeptide binding]; other site 1233100009624 metal binding site [ion binding]; metal-binding site 1233100009625 substrate binding pocket [chemical binding]; other site 1233100009626 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1233100009627 phosphoglyceromutase; Provisional; Region: PRK05434 1233100009628 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1233100009629 triosephosphate isomerase; Provisional; Region: PRK14565 1233100009630 substrate binding site [chemical binding]; other site 1233100009631 dimer interface [polypeptide binding]; other site 1233100009632 catalytic triad [active] 1233100009633 Phosphoglycerate kinase; Region: PGK; pfam00162 1233100009634 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1233100009635 substrate binding site [chemical binding]; other site 1233100009636 hinge regions; other site 1233100009637 ADP binding site [chemical binding]; other site 1233100009638 catalytic site [active] 1233100009639 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1233100009640 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1233100009641 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1233100009642 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1233100009643 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1233100009644 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1233100009645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100009646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100009647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100009648 DNA-binding site [nucleotide binding]; DNA binding site 1233100009649 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100009650 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1233100009651 putative dimerization interface [polypeptide binding]; other site 1233100009652 putative ligand binding site [chemical binding]; other site 1233100009653 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1233100009654 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1233100009655 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1233100009656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100009657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100009658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233100009659 dimerization interface [polypeptide binding]; other site 1233100009660 EamA-like transporter family; Region: EamA; pfam00892 1233100009661 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1233100009662 EamA-like transporter family; Region: EamA; pfam00892 1233100009663 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1233100009664 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1233100009665 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1233100009666 active site 1233100009667 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1233100009668 iron-sulfur cluster-binding protein; Region: TIGR00273 1233100009669 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1233100009670 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1233100009671 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1233100009672 Cysteine-rich domain; Region: CCG; pfam02754 1233100009673 Cysteine-rich domain; Region: CCG; pfam02754 1233100009674 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233100009675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100009676 active site 1233100009677 phosphorylation site [posttranslational modification] 1233100009678 intermolecular recognition site; other site 1233100009679 dimerization interface [polypeptide binding]; other site 1233100009680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233100009681 DNA binding residues [nucleotide binding] 1233100009682 dimerization interface [polypeptide binding]; other site 1233100009683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1233100009684 Histidine kinase; Region: HisKA_3; pfam07730 1233100009685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100009686 ATP binding site [chemical binding]; other site 1233100009687 Mg2+ binding site [ion binding]; other site 1233100009688 G-X-G motif; other site 1233100009689 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1233100009690 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1233100009691 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1233100009692 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233100009693 Walker A/P-loop; other site 1233100009694 ATP binding site [chemical binding]; other site 1233100009695 Q-loop/lid; other site 1233100009696 ABC transporter signature motif; other site 1233100009697 Walker B; other site 1233100009698 D-loop; other site 1233100009699 H-loop/switch region; other site 1233100009700 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1233100009701 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1233100009702 catalytic site [active] 1233100009703 PAS domain S-box; Region: sensory_box; TIGR00229 1233100009704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100009705 putative active site [active] 1233100009706 heme pocket [chemical binding]; other site 1233100009707 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1233100009708 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1233100009709 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1233100009710 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1233100009711 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1233100009712 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1233100009713 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1233100009714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233100009715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009716 dimer interface [polypeptide binding]; other site 1233100009717 conserved gate region; other site 1233100009718 putative PBP binding loops; other site 1233100009719 ABC-ATPase subunit interface; other site 1233100009720 TM2 domain; Region: TM2; pfam05154 1233100009721 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1233100009722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009723 dimer interface [polypeptide binding]; other site 1233100009724 conserved gate region; other site 1233100009725 ABC-ATPase subunit interface; other site 1233100009726 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1233100009727 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233100009728 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100009729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100009730 DNA binding site [nucleotide binding] 1233100009731 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1233100009732 putative dimerization interface [polypeptide binding]; other site 1233100009733 putative ligand binding site [chemical binding]; other site 1233100009734 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1233100009735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100009736 DNA-binding site [nucleotide binding]; DNA binding site 1233100009737 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1233100009738 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1233100009739 L-lactate permease; Region: Lactate_perm; pfam02652 1233100009740 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1233100009741 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1233100009742 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1233100009743 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1233100009744 YvfG protein; Region: YvfG; pfam09628 1233100009745 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1233100009746 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1233100009747 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1233100009748 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1233100009749 inhibitor-cofactor binding pocket; inhibition site 1233100009750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100009751 catalytic residue [active] 1233100009752 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1233100009753 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1233100009754 putative trimer interface [polypeptide binding]; other site 1233100009755 putative CoA binding site [chemical binding]; other site 1233100009756 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1233100009757 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1233100009758 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1233100009759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100009760 active site 1233100009761 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1233100009762 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1233100009763 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100009764 active site 1233100009765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233100009766 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1233100009767 putative ADP-binding pocket [chemical binding]; other site 1233100009768 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1233100009769 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1233100009770 active site 1233100009771 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1233100009772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233100009773 putative ADP-binding pocket [chemical binding]; other site 1233100009774 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1233100009775 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1233100009776 NAD(P) binding site [chemical binding]; other site 1233100009777 homodimer interface [polypeptide binding]; other site 1233100009778 substrate binding site [chemical binding]; other site 1233100009779 active site 1233100009780 AAA domain; Region: AAA_31; pfam13614 1233100009781 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233100009782 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1233100009783 Chain length determinant protein; Region: Wzz; cl15801 1233100009784 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1233100009785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100009786 non-specific DNA binding site [nucleotide binding]; other site 1233100009787 salt bridge; other site 1233100009788 sequence-specific DNA binding site [nucleotide binding]; other site 1233100009789 Anti-repressor SinI; Region: SinI; pfam08671 1233100009790 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1233100009791 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1233100009792 substrate binding pocket [chemical binding]; other site 1233100009793 catalytic triad [active] 1233100009794 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1233100009795 hypothetical protein; Provisional; Region: PRK00872 1233100009796 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1233100009797 aspartate racemase; Region: asp_race; TIGR00035 1233100009798 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1233100009799 Beta-lactamase; Region: Beta-lactamase; pfam00144 1233100009800 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1233100009801 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1233100009802 active site 1233100009803 amino acid transporter; Region: 2A0306; TIGR00909 1233100009804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100009805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100009806 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1233100009807 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1233100009808 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1233100009809 Clp protease; Region: CLP_protease; pfam00574 1233100009810 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1233100009811 oligomer interface [polypeptide binding]; other site 1233100009812 active site residues [active] 1233100009813 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1233100009814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100009815 motif II; other site 1233100009816 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1233100009817 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1233100009818 Ca binding site [ion binding]; other site 1233100009819 active site 1233100009820 catalytic site [active] 1233100009821 maltose phosphorylase; Provisional; Region: PRK13807 1233100009822 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1233100009823 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1233100009824 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1233100009825 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1233100009826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009827 dimer interface [polypeptide binding]; other site 1233100009828 conserved gate region; other site 1233100009829 ABC-ATPase subunit interface; other site 1233100009830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100009831 dimer interface [polypeptide binding]; other site 1233100009832 conserved gate region; other site 1233100009833 putative PBP binding loops; other site 1233100009834 ABC-ATPase subunit interface; other site 1233100009835 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1233100009836 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1233100009837 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1233100009838 homodimer interface [polypeptide binding]; other site 1233100009839 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1233100009840 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1233100009841 active site 1233100009842 homodimer interface [polypeptide binding]; other site 1233100009843 catalytic site [active] 1233100009844 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100009845 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100009846 DNA binding site [nucleotide binding] 1233100009847 domain linker motif; other site 1233100009848 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1233100009849 ligand binding site [chemical binding]; other site 1233100009850 dimerization interface [polypeptide binding]; other site 1233100009851 TIGR00730 family protein; Region: TIGR00730 1233100009852 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1233100009853 metal binding site [ion binding]; metal-binding site 1233100009854 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1233100009855 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1233100009856 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1233100009857 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1233100009858 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1233100009859 active site clefts [active] 1233100009860 zinc binding site [ion binding]; other site 1233100009861 dimer interface [polypeptide binding]; other site 1233100009862 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1233100009863 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1233100009864 dimerization interface [polypeptide binding]; other site 1233100009865 ligand binding site [chemical binding]; other site 1233100009866 NADP binding site [chemical binding]; other site 1233100009867 catalytic site [active] 1233100009868 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1233100009869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1233100009870 Walker A/P-loop; other site 1233100009871 ATP binding site [chemical binding]; other site 1233100009872 Q-loop/lid; other site 1233100009873 ABC transporter signature motif; other site 1233100009874 Walker B; other site 1233100009875 D-loop; other site 1233100009876 H-loop/switch region; other site 1233100009877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100009878 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1233100009879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100009880 ATP binding site [chemical binding]; other site 1233100009881 Mg2+ binding site [ion binding]; other site 1233100009882 G-X-G motif; other site 1233100009883 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100009884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100009885 active site 1233100009886 phosphorylation site [posttranslational modification] 1233100009887 intermolecular recognition site; other site 1233100009888 dimerization interface [polypeptide binding]; other site 1233100009889 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100009890 DNA binding site [nucleotide binding] 1233100009891 Lysis protein; Region: Lysis_col; pfam02402 1233100009892 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1233100009893 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1233100009894 dimerization domain swap beta strand [polypeptide binding]; other site 1233100009895 regulatory protein interface [polypeptide binding]; other site 1233100009896 active site 1233100009897 regulatory phosphorylation site [posttranslational modification]; other site 1233100009898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1233100009899 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1233100009900 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1233100009901 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1233100009902 phosphate binding site [ion binding]; other site 1233100009903 putative substrate binding pocket [chemical binding]; other site 1233100009904 dimer interface [polypeptide binding]; other site 1233100009905 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1233100009906 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1233100009907 putative active site [active] 1233100009908 nucleotide binding site [chemical binding]; other site 1233100009909 nudix motif; other site 1233100009910 putative metal binding site [ion binding]; other site 1233100009911 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1233100009912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233100009913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100009914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1233100009915 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233100009916 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233100009917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100009918 binding surface 1233100009919 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1233100009920 TPR motif; other site 1233100009921 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1233100009922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100009923 TPR motif; other site 1233100009924 binding surface 1233100009925 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233100009926 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100009927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100009928 Walker A/P-loop; other site 1233100009929 ATP binding site [chemical binding]; other site 1233100009930 Q-loop/lid; other site 1233100009931 ABC transporter signature motif; other site 1233100009932 Walker B; other site 1233100009933 D-loop; other site 1233100009934 H-loop/switch region; other site 1233100009935 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1233100009936 metal binding site [ion binding]; metal-binding site 1233100009937 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1233100009938 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1233100009939 substrate binding site [chemical binding]; other site 1233100009940 glutamase interaction surface [polypeptide binding]; other site 1233100009941 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1233100009942 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1233100009943 catalytic residues [active] 1233100009944 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1233100009945 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1233100009946 putative active site [active] 1233100009947 oxyanion strand; other site 1233100009948 catalytic triad [active] 1233100009949 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1233100009950 histidinol dehydrogenase; Region: hisD; TIGR00069 1233100009951 NAD binding site [chemical binding]; other site 1233100009952 dimerization interface [polypeptide binding]; other site 1233100009953 product binding site; other site 1233100009954 substrate binding site [chemical binding]; other site 1233100009955 zinc binding site [ion binding]; other site 1233100009956 catalytic residues [active] 1233100009957 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1233100009958 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1233100009959 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1233100009960 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1233100009961 dimer interface [polypeptide binding]; other site 1233100009962 motif 1; other site 1233100009963 active site 1233100009964 motif 2; other site 1233100009965 motif 3; other site 1233100009966 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1233100009967 putative active site [active] 1233100009968 Pectate lyase; Region: Pectate_lyase; pfam03211 1233100009969 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1233100009970 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1233100009971 trimer interface [polypeptide binding]; other site 1233100009972 active site 1233100009973 substrate binding site [chemical binding]; other site 1233100009974 CoA binding site [chemical binding]; other site 1233100009975 Nucleoside recognition; Region: Gate; pfam07670 1233100009976 Nucleoside recognition; Region: Gate; pfam07670 1233100009977 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1233100009978 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1233100009979 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1233100009980 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1233100009981 Hpr binding site; other site 1233100009982 active site 1233100009983 homohexamer subunit interaction site [polypeptide binding]; other site 1233100009984 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1233100009985 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1233100009986 active site 1233100009987 dimer interface [polypeptide binding]; other site 1233100009988 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1233100009989 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1233100009990 active site 1233100009991 trimer interface [polypeptide binding]; other site 1233100009992 allosteric site; other site 1233100009993 active site lid [active] 1233100009994 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1233100009995 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233100009996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100009997 DNA-binding site [nucleotide binding]; DNA binding site 1233100009998 UTRA domain; Region: UTRA; pfam07702 1233100009999 Lamin Tail Domain; Region: LTD; pfam00932 1233100010000 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1233100010001 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1233100010002 putative active site [active] 1233100010003 putative metal binding site [ion binding]; other site 1233100010004 Predicted membrane protein [Function unknown]; Region: COG1950 1233100010005 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1233100010006 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1233100010007 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1233100010008 flagellin; Provisional; Region: PRK12804 1233100010009 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1233100010010 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1233100010011 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1233100010012 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1233100010013 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1233100010014 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1233100010015 excinuclease ABC subunit B; Provisional; Region: PRK05298 1233100010016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100010017 ATP binding site [chemical binding]; other site 1233100010018 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100010019 nucleotide binding region [chemical binding]; other site 1233100010020 ATP-binding site [chemical binding]; other site 1233100010021 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1233100010022 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1233100010023 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1233100010024 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 1233100010025 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1233100010026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100010027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100010028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100010029 putative substrate translocation pore; other site 1233100010030 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1233100010031 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1233100010032 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1233100010033 C-terminal peptidase (prc); Region: prc; TIGR00225 1233100010034 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1233100010035 protein binding site [polypeptide binding]; other site 1233100010036 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1233100010037 Catalytic dyad [active] 1233100010038 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1233100010039 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1233100010040 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1233100010041 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1233100010042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100010043 Walker A/P-loop; other site 1233100010044 ATP binding site [chemical binding]; other site 1233100010045 Q-loop/lid; other site 1233100010046 ABC transporter signature motif; other site 1233100010047 Walker B; other site 1233100010048 D-loop; other site 1233100010049 H-loop/switch region; other site 1233100010050 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1233100010051 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1233100010052 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233100010053 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100010054 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100010055 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233100010056 peptide chain release factor 2; Provisional; Region: PRK06746 1233100010057 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1233100010058 RF-1 domain; Region: RF-1; pfam00472 1233100010059 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1233100010060 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1233100010061 nucleotide binding region [chemical binding]; other site 1233100010062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1233100010063 ATP-binding site [chemical binding]; other site 1233100010064 SEC-C motif; Region: SEC-C; pfam02810 1233100010065 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1233100010066 30S subunit binding site; other site 1233100010067 Flagellar protein FliT; Region: FliT; pfam05400 1233100010068 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 1233100010069 flagellar capping protein; Validated; Region: fliD; PRK07737 1233100010070 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1233100010071 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1233100010072 FlaG protein; Region: FlaG; cl00591 1233100010073 carbon storage regulator; Provisional; Region: PRK01712 1233100010074 flagellar assembly protein FliW; Provisional; Region: PRK13285 1233100010075 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1233100010076 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1233100010077 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1233100010078 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1233100010079 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1233100010080 FlgN protein; Region: FlgN; pfam05130 1233100010081 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 1233100010082 flagellar operon protein TIGR03826; Region: YvyF 1233100010083 comF family protein; Region: comF; TIGR00201 1233100010084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100010085 active site 1233100010086 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1233100010087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100010088 ATP binding site [chemical binding]; other site 1233100010089 putative Mg++ binding site [ion binding]; other site 1233100010090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100010091 nucleotide binding region [chemical binding]; other site 1233100010092 ATP-binding site [chemical binding]; other site 1233100010093 EDD domain protein, DegV family; Region: DegV; TIGR00762 1233100010094 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1233100010095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233100010096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100010097 active site 1233100010098 phosphorylation site [posttranslational modification] 1233100010099 intermolecular recognition site; other site 1233100010100 dimerization interface [polypeptide binding]; other site 1233100010101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233100010102 DNA binding residues [nucleotide binding] 1233100010103 dimerization interface [polypeptide binding]; other site 1233100010104 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1233100010105 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1233100010106 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1233100010107 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1233100010108 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1233100010109 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1233100010110 Mg++ binding site [ion binding]; other site 1233100010111 putative catalytic motif [active] 1233100010112 substrate binding site [chemical binding]; other site 1233100010113 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1233100010114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233100010115 putative homodimer interface [polypeptide binding]; other site 1233100010116 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1233100010117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100010118 active site 1233100010119 Chain length determinant protein; Region: Wzz; pfam02706 1233100010120 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1233100010121 O-Antigen ligase; Region: Wzy_C; pfam04932 1233100010122 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1233100010123 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1233100010124 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1233100010125 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1233100010126 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1233100010127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233100010128 colanic acid exporter; Provisional; Region: PRK10459 1233100010129 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1233100010130 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1233100010131 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1233100010132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100010133 active site 1233100010134 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1233100010135 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1233100010136 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1233100010137 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1233100010138 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1233100010139 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1233100010140 active site 1233100010141 metal binding site [ion binding]; metal-binding site 1233100010142 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1233100010143 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1233100010144 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1233100010145 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1233100010146 Stage II sporulation protein; Region: SpoIID; pfam08486 1233100010147 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1233100010148 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1233100010149 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1233100010150 active site 1233100010151 homodimer interface [polypeptide binding]; other site 1233100010152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100010153 active site 1233100010154 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1233100010155 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1233100010156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1233100010157 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1233100010158 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1233100010159 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1233100010160 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1233100010161 Walker A/P-loop; other site 1233100010162 ATP binding site [chemical binding]; other site 1233100010163 Q-loop/lid; other site 1233100010164 ABC transporter signature motif; other site 1233100010165 Walker B; other site 1233100010166 D-loop; other site 1233100010167 H-loop/switch region; other site 1233100010168 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1233100010169 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1233100010170 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1233100010171 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100010172 active site 1233100010173 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1233100010174 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100010175 active site 1233100010176 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1233100010177 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1233100010178 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1233100010179 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1233100010180 active site 1233100010181 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1233100010182 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1233100010183 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1233100010184 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1233100010185 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1233100010186 substrate binding site; other site 1233100010187 dimer interface; other site 1233100010188 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1233100010189 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1233100010190 putative NAD(P) binding site [chemical binding]; other site 1233100010191 putative catalytic Zn binding site [ion binding]; other site 1233100010192 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1233100010193 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1233100010194 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1233100010195 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1233100010196 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1233100010197 Bacterial SH3 domain; Region: SH3_3; pfam08239 1233100010198 Lysozyme subfamily 2; Region: LYZ2; smart00047 1233100010199 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1233100010200 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1233100010201 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1233100010202 Spore germination protein; Region: Spore_permease; pfam03845 1233100010203 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1233100010204 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1233100010205 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1233100010206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100010207 putative substrate translocation pore; other site 1233100010208 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1233100010209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100010210 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1233100010211 active site 1233100010212 motif I; other site 1233100010213 motif II; other site 1233100010214 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1233100010215 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233100010216 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233100010217 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233100010218 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233100010219 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1233100010220 NlpC/P60 family; Region: NLPC_P60; pfam00877 1233100010221 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1233100010222 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1233100010223 putative active site [active] 1233100010224 putative metal binding site [ion binding]; other site 1233100010225 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1233100010226 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1233100010227 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1233100010228 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1233100010229 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100010230 DNA binding site [nucleotide binding] 1233100010231 domain linker motif; other site 1233100010232 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1233100010233 dimerization interface [polypeptide binding]; other site 1233100010234 ligand binding site [chemical binding]; other site 1233100010235 sodium binding site [ion binding]; other site 1233100010236 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1233100010237 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1233100010238 substrate binding site [chemical binding]; other site 1233100010239 dimer interface [polypeptide binding]; other site 1233100010240 ATP binding site [chemical binding]; other site 1233100010241 D-ribose pyranase; Provisional; Region: PRK11797 1233100010242 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1233100010243 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1233100010244 Walker A/P-loop; other site 1233100010245 ATP binding site [chemical binding]; other site 1233100010246 Q-loop/lid; other site 1233100010247 ABC transporter signature motif; other site 1233100010248 Walker B; other site 1233100010249 D-loop; other site 1233100010250 H-loop/switch region; other site 1233100010251 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1233100010252 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1233100010253 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1233100010254 ligand binding site [chemical binding]; other site 1233100010255 dimerization interface [polypeptide binding]; other site 1233100010256 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1233100010257 Bacterial SH3 domain; Region: SH3_3; cl17532 1233100010258 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1233100010259 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1233100010260 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1233100010261 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1233100010262 acetolactate synthase; Reviewed; Region: PRK08617 1233100010263 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1233100010264 PYR/PP interface [polypeptide binding]; other site 1233100010265 dimer interface [polypeptide binding]; other site 1233100010266 TPP binding site [chemical binding]; other site 1233100010267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1233100010268 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1233100010269 TPP-binding site [chemical binding]; other site 1233100010270 dimer interface [polypeptide binding]; other site 1233100010271 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1233100010272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100010273 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1233100010274 putative dimerization interface [polypeptide binding]; other site 1233100010275 putative substrate binding pocket [chemical binding]; other site 1233100010276 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1233100010277 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1233100010278 transmembrane helices; other site 1233100010279 CotH protein; Region: CotH; pfam08757 1233100010280 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1233100010281 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1233100010282 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1233100010283 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1233100010284 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1233100010285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100010286 putative DNA binding site [nucleotide binding]; other site 1233100010287 putative Zn2+ binding site [ion binding]; other site 1233100010288 AsnC family; Region: AsnC_trans_reg; pfam01037 1233100010289 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1233100010290 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1233100010291 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1233100010292 Active_site [active] 1233100010293 LXG domain of WXG superfamily; Region: LXG; pfam04740 1233100010294 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1233100010295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1233100010296 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1233100010297 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1233100010298 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1233100010299 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1233100010300 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1233100010301 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1233100010302 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233100010303 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1233100010304 Chain length determinant protein; Region: Wzz; cl15801 1233100010305 SWIM zinc finger; Region: SWIM; pfam04434 1233100010306 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1233100010307 SNF2 Helicase protein; Region: DUF3670; pfam12419 1233100010308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100010309 ATP binding site [chemical binding]; other site 1233100010310 putative Mg++ binding site [ion binding]; other site 1233100010311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100010312 nucleotide binding region [chemical binding]; other site 1233100010313 ATP-binding site [chemical binding]; other site 1233100010314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100010315 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1233100010316 active site 1233100010317 motif I; other site 1233100010318 motif II; other site 1233100010319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100010320 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1233100010321 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1233100010322 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1233100010323 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1233100010324 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1233100010325 dimer interface [polypeptide binding]; other site 1233100010326 ssDNA binding site [nucleotide binding]; other site 1233100010327 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233100010328 YwpF-like protein; Region: YwpF; pfam14183 1233100010329 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1233100010330 Collagen binding domain; Region: Collagen_bind; pfam05737 1233100010331 Collagen binding domain; Region: Collagen_bind; pfam05737 1233100010332 Collagen binding domain; Region: Collagen_bind; pfam05737 1233100010333 Cna protein B-type domain; Region: Cna_B; pfam05738 1233100010334 Cna protein B-type domain; Region: Cna_B; pfam05738 1233100010335 Cna protein B-type domain; Region: Cna_B; pfam05738 1233100010336 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1233100010337 Cna protein B-type domain; Region: Cna_B; pfam05738 1233100010338 Cna protein B-type domain; Region: Cna_B; pfam05738 1233100010339 Cna protein B-type domain; Region: Cna_B; pfam05738 1233100010340 Cna protein B-type domain; Region: Cna_B; pfam05738 1233100010341 Cna protein B-type domain; Region: Cna_B; pfam05738 1233100010342 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1233100010343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100010344 active site 1233100010345 phosphorylation site [posttranslational modification] 1233100010346 intermolecular recognition site; other site 1233100010347 dimerization interface [polypeptide binding]; other site 1233100010348 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1233100010349 DNA binding site [nucleotide binding] 1233100010350 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1233100010351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100010352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100010353 dimer interface [polypeptide binding]; other site 1233100010354 phosphorylation site [posttranslational modification] 1233100010355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100010356 ATP binding site [chemical binding]; other site 1233100010357 Mg2+ binding site [ion binding]; other site 1233100010358 G-X-G motif; other site 1233100010359 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1233100010360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100010361 active site 1233100010362 phosphorylation site [posttranslational modification] 1233100010363 intermolecular recognition site; other site 1233100010364 dimerization interface [polypeptide binding]; other site 1233100010365 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1233100010366 Histidine kinase; Region: His_kinase; pfam06580 1233100010367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100010368 ATP binding site [chemical binding]; other site 1233100010369 Mg2+ binding site [ion binding]; other site 1233100010370 G-X-G motif; other site 1233100010371 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1233100010372 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1233100010373 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1233100010374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100010375 binding surface 1233100010376 TPR motif; other site 1233100010377 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1233100010378 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1233100010379 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1233100010380 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1233100010381 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1233100010382 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1233100010383 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1233100010384 MreB and similar proteins; Region: MreB_like; cd10225 1233100010385 nucleotide binding site [chemical binding]; other site 1233100010386 Mg binding site [ion binding]; other site 1233100010387 putative protofilament interaction site [polypeptide binding]; other site 1233100010388 RodZ interaction site [polypeptide binding]; other site 1233100010389 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1233100010390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100010391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100010392 putative Zn2+ binding site [ion binding]; other site 1233100010393 putative DNA binding site [nucleotide binding]; other site 1233100010394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100010395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100010396 putative substrate translocation pore; other site 1233100010397 Right handed beta helix region; Region: Beta_helix; pfam13229 1233100010398 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1233100010399 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1233100010400 Na binding site [ion binding]; other site 1233100010401 putative substrate binding site [chemical binding]; other site 1233100010402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100010403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100010404 putative substrate translocation pore; other site 1233100010405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100010406 Isochorismatase family; Region: Isochorismatase; pfam00857 1233100010407 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1233100010408 catalytic triad [active] 1233100010409 conserved cis-peptide bond; other site 1233100010410 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1233100010411 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1233100010412 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1233100010413 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1233100010414 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1233100010415 active site 1233100010416 VanZ like family; Region: VanZ; pfam04892 1233100010417 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1233100010418 Peptidase family M23; Region: Peptidase_M23; pfam01551 1233100010419 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1233100010420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100010421 Coenzyme A binding pocket [chemical binding]; other site 1233100010422 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1233100010423 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1233100010424 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1233100010425 putative active site [active] 1233100010426 catalytic site [active] 1233100010427 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1233100010428 putative active site [active] 1233100010429 catalytic site [active] 1233100010430 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1233100010431 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1233100010432 NAD binding site [chemical binding]; other site 1233100010433 substrate binding site [chemical binding]; other site 1233100010434 putative active site [active] 1233100010435 Predicted transcriptional regulator [Transcription]; Region: COG1959 1233100010436 Transcriptional regulator; Region: Rrf2; pfam02082 1233100010437 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1233100010438 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1233100010439 subunit interactions [polypeptide binding]; other site 1233100010440 active site 1233100010441 flap region; other site 1233100010442 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1233100010443 gamma-beta subunit interface [polypeptide binding]; other site 1233100010444 alpha-beta subunit interface [polypeptide binding]; other site 1233100010445 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1233100010446 alpha-gamma subunit interface [polypeptide binding]; other site 1233100010447 beta-gamma subunit interface [polypeptide binding]; other site 1233100010448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100010449 Walker B; other site 1233100010450 D-loop; other site 1233100010451 H-loop/switch region; other site 1233100010452 CsbD-like; Region: CsbD; pfam05532 1233100010453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1233100010454 binding surface 1233100010455 TPR motif; other site 1233100010456 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233100010457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100010458 binding surface 1233100010459 TPR motif; other site 1233100010460 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1233100010461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100010462 FeS/SAM binding site; other site 1233100010463 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1233100010464 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1233100010465 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1233100010466 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1233100010467 metal ion-dependent adhesion site (MIDAS); other site 1233100010468 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1233100010469 metal ion-dependent adhesion site (MIDAS); other site 1233100010470 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1233100010471 Stage II sporulation protein; Region: SpoIID; pfam08486 1233100010472 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1233100010473 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1233100010474 hinge; other site 1233100010475 active site 1233100010476 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1233100010477 Predicted membrane protein [Function unknown]; Region: COG4836 1233100010478 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1233100010479 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1233100010480 epsilon subunit interface [polypeptide binding]; other site 1233100010481 LBP interface [polypeptide binding]; other site 1233100010482 gamma subunit interface [polypeptide binding]; other site 1233100010483 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1233100010484 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1233100010485 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1233100010486 alpha subunit interaction interface [polypeptide binding]; other site 1233100010487 Walker A motif; other site 1233100010488 ATP binding site [chemical binding]; other site 1233100010489 Walker B motif; other site 1233100010490 inhibitor binding site; inhibition site 1233100010491 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1233100010492 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1233100010493 core domain interface [polypeptide binding]; other site 1233100010494 delta subunit interface [polypeptide binding]; other site 1233100010495 epsilon subunit interface [polypeptide binding]; other site 1233100010496 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1233100010497 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1233100010498 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1233100010499 beta subunit interaction interface [polypeptide binding]; other site 1233100010500 Walker A motif; other site 1233100010501 ATP binding site [chemical binding]; other site 1233100010502 Walker B motif; other site 1233100010503 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1233100010504 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1233100010505 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1233100010506 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1233100010507 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1233100010508 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1233100010509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1233100010510 active site 1233100010511 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1233100010512 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1233100010513 dimer interface [polypeptide binding]; other site 1233100010514 active site 1233100010515 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1233100010516 folate binding site [chemical binding]; other site 1233100010517 hypothetical protein; Provisional; Region: PRK13690 1233100010518 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1233100010519 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1233100010520 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1233100010521 active site 1233100010522 Predicted membrane protein [Function unknown]; Region: COG1971 1233100010523 Domain of unknown function DUF; Region: DUF204; pfam02659 1233100010524 Domain of unknown function DUF; Region: DUF204; pfam02659 1233100010525 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1233100010526 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1233100010527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1233100010528 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1233100010529 HemK family putative methylases; Region: hemK_fam; TIGR00536 1233100010530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100010531 S-adenosylmethionine binding site [chemical binding]; other site 1233100010532 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1233100010533 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1233100010534 RF-1 domain; Region: RF-1; pfam00472 1233100010535 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1233100010536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100010537 putative metal binding site [ion binding]; other site 1233100010538 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1233100010539 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1233100010540 DNA binding residues [nucleotide binding] 1233100010541 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1233100010542 malate dehydrogenase; Provisional; Region: PRK13529 1233100010543 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1233100010544 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1233100010545 NAD(P) binding site [chemical binding]; other site 1233100010546 thymidine kinase; Provisional; Region: PRK04296 1233100010547 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1233100010548 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1233100010549 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1233100010550 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1233100010551 RNA binding site [nucleotide binding]; other site 1233100010552 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1233100010553 multimer interface [polypeptide binding]; other site 1233100010554 Walker A motif; other site 1233100010555 ATP binding site [chemical binding]; other site 1233100010556 Walker B motif; other site 1233100010557 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1233100010558 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1233100010559 putative active site [active] 1233100010560 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1233100010561 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1233100010562 hinge; other site 1233100010563 active site 1233100010564 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1233100010565 active site 1233100010566 intersubunit interactions; other site 1233100010567 catalytic residue [active] 1233100010568 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1233100010569 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1233100010570 intersubunit interface [polypeptide binding]; other site 1233100010571 active site 1233100010572 zinc binding site [ion binding]; other site 1233100010573 Na+ binding site [ion binding]; other site 1233100010574 Response regulator receiver domain; Region: Response_reg; pfam00072 1233100010575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100010576 active site 1233100010577 phosphorylation site [posttranslational modification] 1233100010578 intermolecular recognition site; other site 1233100010579 dimerization interface [polypeptide binding]; other site 1233100010580 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1233100010581 CTP synthetase; Validated; Region: pyrG; PRK05380 1233100010582 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1233100010583 Catalytic site [active] 1233100010584 active site 1233100010585 UTP binding site [chemical binding]; other site 1233100010586 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1233100010587 active site 1233100010588 putative oxyanion hole; other site 1233100010589 catalytic triad [active] 1233100010590 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1233100010591 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1233100010592 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1233100010593 FAD binding site [chemical binding]; other site 1233100010594 homotetramer interface [polypeptide binding]; other site 1233100010595 substrate binding pocket [chemical binding]; other site 1233100010596 catalytic base [active] 1233100010597 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1233100010598 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1233100010599 Cysteine-rich domain; Region: CCG; pfam02754 1233100010600 Cysteine-rich domain; Region: CCG; pfam02754 1233100010601 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1233100010602 putative active site [active] 1233100010603 catalytic site [active] 1233100010604 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1233100010605 PLD-like domain; Region: PLDc_2; pfam13091 1233100010606 putative active site [active] 1233100010607 catalytic site [active] 1233100010608 UV-endonuclease UvdE; Region: UvdE; cl10036 1233100010609 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1233100010610 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1233100010611 folate binding site [chemical binding]; other site 1233100010612 NADP+ binding site [chemical binding]; other site 1233100010613 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1233100010614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100010615 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1233100010616 Walker A/P-loop; other site 1233100010617 ATP binding site [chemical binding]; other site 1233100010618 Q-loop/lid; other site 1233100010619 ABC transporter signature motif; other site 1233100010620 Walker B; other site 1233100010621 D-loop; other site 1233100010622 H-loop/switch region; other site 1233100010623 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1233100010624 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1233100010625 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1233100010626 putative active site [active] 1233100010627 catalytic site [active] 1233100010628 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1233100010629 putative active site [active] 1233100010630 catalytic site [active] 1233100010631 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1233100010632 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1233100010633 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1233100010634 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1233100010635 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1233100010636 [4Fe-4S] binding site [ion binding]; other site 1233100010637 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1233100010638 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1233100010639 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1233100010640 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1233100010641 molybdopterin cofactor binding site; other site 1233100010642 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1233100010643 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1233100010644 ligand binding site [chemical binding]; other site 1233100010645 flexible hinge region; other site 1233100010646 YwiC-like protein; Region: YwiC; pfam14256 1233100010647 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1233100010648 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1233100010649 ligand binding site [chemical binding]; other site 1233100010650 flexible hinge region; other site 1233100010651 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1233100010652 putative switch regulator; other site 1233100010653 non-specific DNA interactions [nucleotide binding]; other site 1233100010654 DNA binding site [nucleotide binding] 1233100010655 sequence specific DNA binding site [nucleotide binding]; other site 1233100010656 putative cAMP binding site [chemical binding]; other site 1233100010657 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1233100010658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100010659 putative substrate translocation pore; other site 1233100010660 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1233100010661 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1233100010662 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1233100010663 active site 1233100010664 HIGH motif; other site 1233100010665 KMSK motif region; other site 1233100010666 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1233100010667 tRNA binding surface [nucleotide binding]; other site 1233100010668 anticodon binding site; other site 1233100010669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1233100010670 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 1233100010671 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1233100010672 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1233100010673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1233100010674 FeS/SAM binding site; other site 1233100010675 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1233100010676 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1233100010677 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233100010678 Walker A/P-loop; other site 1233100010679 ATP binding site [chemical binding]; other site 1233100010680 Q-loop/lid; other site 1233100010681 ABC transporter signature motif; other site 1233100010682 Walker B; other site 1233100010683 D-loop; other site 1233100010684 H-loop/switch region; other site 1233100010685 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1233100010686 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1233100010687 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1233100010688 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1233100010689 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1233100010690 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1233100010691 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1233100010692 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1233100010693 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1233100010694 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1233100010695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1233100010696 binding surface 1233100010697 TPR motif; other site 1233100010698 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1233100010699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1233100010700 binding surface 1233100010701 TPR motif; other site 1233100010702 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1233100010703 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1233100010704 Walker A/P-loop; other site 1233100010705 ATP binding site [chemical binding]; other site 1233100010706 Q-loop/lid; other site 1233100010707 ABC transporter signature motif; other site 1233100010708 Walker B; other site 1233100010709 D-loop; other site 1233100010710 H-loop/switch region; other site 1233100010711 agmatinase; Region: agmatinase; TIGR01230 1233100010712 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1233100010713 putative active site [active] 1233100010714 Mn binding site [ion binding]; other site 1233100010715 spermidine synthase; Provisional; Region: PRK00811 1233100010716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100010717 Transglycosylase; Region: Transgly; pfam00912 1233100010718 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1233100010719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1233100010720 YwhD family; Region: YwhD; pfam08741 1233100010721 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1233100010722 Peptidase family M50; Region: Peptidase_M50; pfam02163 1233100010723 active site 1233100010724 putative substrate binding region [chemical binding]; other site 1233100010725 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1233100010726 active site 1 [active] 1233100010727 dimer interface [polypeptide binding]; other site 1233100010728 hexamer interface [polypeptide binding]; other site 1233100010729 active site 2 [active] 1233100010730 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100010731 MarR family; Region: MarR; pfam01047 1233100010732 MarR family; Region: MarR_2; cl17246 1233100010733 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1233100010734 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1233100010735 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1233100010736 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1233100010737 active site 1233100010738 dimer interface [polypeptide binding]; other site 1233100010739 motif 1; other site 1233100010740 motif 2; other site 1233100010741 motif 3; other site 1233100010742 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1233100010743 anticodon binding site; other site 1233100010744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100010745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100010746 putative substrate translocation pore; other site 1233100010747 Rrf2 family protein; Region: rrf2_super; TIGR00738 1233100010748 Transcriptional regulator; Region: Rrf2; pfam02082 1233100010749 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1233100010750 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1233100010751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1233100010752 Zn2+ binding site [ion binding]; other site 1233100010753 Mg2+ binding site [ion binding]; other site 1233100010754 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1233100010755 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1233100010756 EamA-like transporter family; Region: EamA; pfam00892 1233100010757 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1233100010758 EamA-like transporter family; Region: EamA; pfam00892 1233100010759 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1233100010760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100010761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100010762 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1233100010763 putative dimerization interface [polypeptide binding]; other site 1233100010764 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1233100010765 putative heme peroxidase; Provisional; Region: PRK12276 1233100010766 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1233100010767 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1233100010768 putative NAD(P) binding site [chemical binding]; other site 1233100010769 putative active site [active] 1233100010770 transaminase; Reviewed; Region: PRK08068 1233100010771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1233100010772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100010773 homodimer interface [polypeptide binding]; other site 1233100010774 catalytic residue [active] 1233100010775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1233100010776 H+ Antiporter protein; Region: 2A0121; TIGR00900 1233100010777 putative substrate translocation pore; other site 1233100010778 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1233100010779 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1233100010780 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1233100010781 classical (c) SDRs; Region: SDR_c; cd05233 1233100010782 NAD(P) binding site [chemical binding]; other site 1233100010783 active site 1233100010784 Cupin domain; Region: Cupin_2; pfam07883 1233100010785 Cupin domain; Region: Cupin_2; pfam07883 1233100010786 Prephenate dehydratase; Region: PDT; pfam00800 1233100010787 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1233100010788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100010789 putative substrate translocation pore; other site 1233100010790 S-methylmethionine transporter; Provisional; Region: PRK11387 1233100010791 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1233100010792 putative metal binding site [ion binding]; other site 1233100010793 putative dimer interface [polypeptide binding]; other site 1233100010794 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1233100010795 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1233100010796 Glutamate binding site [chemical binding]; other site 1233100010797 homodimer interface [polypeptide binding]; other site 1233100010798 NAD binding site [chemical binding]; other site 1233100010799 catalytic residues [active] 1233100010800 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1233100010801 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1233100010802 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1233100010803 NAD(P) binding site [chemical binding]; other site 1233100010804 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1233100010805 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1233100010806 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1233100010807 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1233100010808 NADP binding site [chemical binding]; other site 1233100010809 active site 1233100010810 putative substrate binding site [chemical binding]; other site 1233100010811 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1233100010812 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1233100010813 NAD binding site [chemical binding]; other site 1233100010814 substrate binding site [chemical binding]; other site 1233100010815 homodimer interface [polypeptide binding]; other site 1233100010816 active site 1233100010817 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1233100010818 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1233100010819 substrate binding site; other site 1233100010820 tetramer interface; other site 1233100010821 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1233100010822 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1233100010823 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1233100010824 ligand binding site; other site 1233100010825 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1233100010826 NeuB family; Region: NeuB; pfam03102 1233100010827 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1233100010828 NeuB binding interface [polypeptide binding]; other site 1233100010829 putative substrate binding site [chemical binding]; other site 1233100010830 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1233100010831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100010832 Coenzyme A binding pocket [chemical binding]; other site 1233100010833 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1233100010834 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1233100010835 inhibitor-cofactor binding pocket; inhibition site 1233100010836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100010837 catalytic residue [active] 1233100010838 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1233100010839 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1233100010840 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1233100010841 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100010842 active site 1233100010843 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1233100010844 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1233100010845 Permease family; Region: Xan_ur_permease; pfam00860 1233100010846 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1233100010847 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1233100010848 NAD(P) binding site [chemical binding]; other site 1233100010849 catalytic residues [active] 1233100010850 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1233100010851 ligand binding site [chemical binding]; other site 1233100010852 active site 1233100010853 UGI interface [polypeptide binding]; other site 1233100010854 catalytic site [active] 1233100010855 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1233100010856 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1233100010857 active site 1233100010858 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1233100010859 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1233100010860 substrate binding [chemical binding]; other site 1233100010861 active site 1233100010862 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1233100010863 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1233100010864 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233100010865 active site turn [active] 1233100010866 phosphorylation site [posttranslational modification] 1233100010867 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233100010868 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1233100010869 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1233100010870 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1233100010871 CAT RNA binding domain; Region: CAT_RBD; smart01061 1233100010872 PRD domain; Region: PRD; pfam00874 1233100010873 PRD domain; Region: PRD; pfam00874 1233100010874 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1233100010875 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1233100010876 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1233100010877 putative active site [active] 1233100010878 catalytic triad [active] 1233100010879 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1233100010880 PA/protease domain interface [polypeptide binding]; other site 1233100010881 putative integrin binding motif; other site 1233100010882 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1233100010883 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1233100010884 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1233100010885 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1233100010886 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1233100010887 dimer interface [polypeptide binding]; other site 1233100010888 FMN binding site [chemical binding]; other site 1233100010889 NADPH bind site [chemical binding]; other site 1233100010890 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1233100010891 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1233100010892 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1233100010893 Subunit I/III interface [polypeptide binding]; other site 1233100010894 Subunit III/IV interface [polypeptide binding]; other site 1233100010895 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1233100010896 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1233100010897 D-pathway; other site 1233100010898 Putative ubiquinol binding site [chemical binding]; other site 1233100010899 Low-spin heme (heme b) binding site [chemical binding]; other site 1233100010900 Putative water exit pathway; other site 1233100010901 Binuclear center (heme o3/CuB) [ion binding]; other site 1233100010902 K-pathway; other site 1233100010903 Putative proton exit pathway; other site 1233100010904 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1233100010905 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1233100010906 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1233100010907 Predicted membrane protein [Function unknown]; Region: COG2261 1233100010908 galactokinase; Provisional; Region: PRK05322 1233100010909 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1233100010910 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1233100010911 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1233100010912 Predicted membrane protein [Function unknown]; Region: COG2246 1233100010913 GtrA-like protein; Region: GtrA; pfam04138 1233100010914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100010915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100010916 Anti-repressor SinI; Region: SinI; pfam08671 1233100010917 Predicted membrane protein [Function unknown]; Region: COG3162 1233100010918 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1233100010919 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1233100010920 Na binding site [ion binding]; other site 1233100010921 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1233100010922 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1233100010923 catalytic residues [active] 1233100010924 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1233100010925 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1233100010926 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1233100010927 Imelysin; Region: Peptidase_M75; pfam09375 1233100010928 FTR1 family protein; Region: TIGR00145 1233100010929 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1233100010930 thiamine phosphate binding site [chemical binding]; other site 1233100010931 active site 1233100010932 pyrophosphate binding site [ion binding]; other site 1233100010933 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1233100010934 substrate binding site [chemical binding]; other site 1233100010935 multimerization interface [polypeptide binding]; other site 1233100010936 ATP binding site [chemical binding]; other site 1233100010937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100010938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100010939 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1233100010940 putative dimerization interface [polypeptide binding]; other site 1233100010941 holin-like protein; Validated; Region: PRK01658 1233100010942 TIGR00659 family protein; Region: TIGR00659 1233100010943 sugar efflux transporter; Region: 2A0120; TIGR00899 1233100010944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100010945 putative substrate translocation pore; other site 1233100010946 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1233100010947 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1233100010948 PUA domain; Region: PUA; cl00607 1233100010949 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1233100010950 putative RNA binding site [nucleotide binding]; other site 1233100010951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100010952 S-adenosylmethionine binding site [chemical binding]; other site 1233100010953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100010954 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1233100010955 active site 1233100010956 metal binding site [ion binding]; metal-binding site 1233100010957 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1233100010958 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1233100010959 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1233100010960 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1233100010961 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1233100010962 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1233100010963 active site 1233100010964 catalytic residues [active] 1233100010965 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1233100010966 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1233100010967 active site turn [active] 1233100010968 phosphorylation site [posttranslational modification] 1233100010969 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233100010970 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1233100010971 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1233100010972 PRD domain; Region: PRD; pfam00874 1233100010973 PRD domain; Region: PRD; pfam00874 1233100010974 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 1233100010975 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1233100010976 Ligand binding site; other site 1233100010977 metal-binding site 1233100010978 Predicted integral membrane protein [Function unknown]; Region: COG5522 1233100010979 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100010980 MarR family; Region: MarR; pfam01047 1233100010981 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1233100010982 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1233100010983 PA/protease domain interface [polypeptide binding]; other site 1233100010984 putative integrin binding motif; other site 1233100010985 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1233100010986 Peptidase family M28; Region: Peptidase_M28; pfam04389 1233100010987 metal binding site [ion binding]; metal-binding site 1233100010988 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1233100010989 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1233100010990 synthetase active site [active] 1233100010991 NTP binding site [chemical binding]; other site 1233100010992 metal binding site [ion binding]; metal-binding site 1233100010993 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1233100010994 UbiA prenyltransferase family; Region: UbiA; pfam01040 1233100010995 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1233100010996 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1233100010997 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1233100010998 acyl-activating enzyme (AAE) consensus motif; other site 1233100010999 AMP binding site [chemical binding]; other site 1233100011000 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1233100011001 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1233100011002 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1233100011003 DltD N-terminal region; Region: DltD_N; pfam04915 1233100011004 DltD central region; Region: DltD_M; pfam04918 1233100011005 DltD C-terminal region; Region: DltD_C; pfam04914 1233100011006 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1233100011007 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1233100011008 putative NAD(P) binding site [chemical binding]; other site 1233100011009 active site 1233100011010 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1233100011011 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1233100011012 homodimer interface [polypeptide binding]; other site 1233100011013 substrate-cofactor binding pocket; other site 1233100011014 catalytic residue [active] 1233100011015 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1233100011016 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1233100011017 NAD binding site [chemical binding]; other site 1233100011018 sugar binding site [chemical binding]; other site 1233100011019 divalent metal binding site [ion binding]; other site 1233100011020 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1233100011021 dimer interface [polypeptide binding]; other site 1233100011022 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1233100011023 methionine cluster; other site 1233100011024 active site 1233100011025 phosphorylation site [posttranslational modification] 1233100011026 metal binding site [ion binding]; metal-binding site 1233100011027 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1233100011028 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1233100011029 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1233100011030 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1233100011031 HTH domain; Region: HTH_11; pfam08279 1233100011032 Mga helix-turn-helix domain; Region: Mga; pfam05043 1233100011033 PRD domain; Region: PRD; pfam00874 1233100011034 PRD domain; Region: PRD; pfam00874 1233100011035 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1233100011036 active site 1233100011037 P-loop; other site 1233100011038 phosphorylation site [posttranslational modification] 1233100011039 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1233100011040 active site 1233100011041 phosphorylation site [posttranslational modification] 1233100011042 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1233100011043 active site 1233100011044 DNA binding site [nucleotide binding] 1233100011045 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1233100011046 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1233100011047 tetramer interface [polypeptide binding]; other site 1233100011048 heme binding pocket [chemical binding]; other site 1233100011049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100011050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100011051 putative substrate translocation pore; other site 1233100011052 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1233100011053 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1233100011054 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1233100011055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1233100011056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1233100011057 DNA binding residues [nucleotide binding] 1233100011058 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1233100011059 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1233100011060 Na binding site [ion binding]; other site 1233100011061 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1233100011062 putative substrate binding site [chemical binding]; other site 1233100011063 putative ATP binding site [chemical binding]; other site 1233100011064 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1233100011065 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100011066 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1233100011067 Walker A/P-loop; other site 1233100011068 ATP binding site [chemical binding]; other site 1233100011069 Q-loop/lid; other site 1233100011070 ABC transporter signature motif; other site 1233100011071 Walker B; other site 1233100011072 D-loop; other site 1233100011073 H-loop/switch region; other site 1233100011074 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1233100011075 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1233100011076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100011077 ATP binding site [chemical binding]; other site 1233100011078 Q-loop/lid; other site 1233100011079 ABC transporter signature motif; other site 1233100011080 Walker B; other site 1233100011081 D-loop; other site 1233100011082 H-loop/switch region; other site 1233100011083 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1233100011084 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1233100011085 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1233100011086 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1233100011087 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1233100011088 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1233100011089 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1233100011090 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1233100011091 putative active site [active] 1233100011092 putative metal binding site [ion binding]; other site 1233100011093 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1233100011094 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1233100011095 Walker A/P-loop; other site 1233100011096 ATP binding site [chemical binding]; other site 1233100011097 Q-loop/lid; other site 1233100011098 ABC transporter signature motif; other site 1233100011099 Walker B; other site 1233100011100 D-loop; other site 1233100011101 H-loop/switch region; other site 1233100011102 TOBE domain; Region: TOBE; pfam03459 1233100011103 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1233100011104 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1233100011105 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1233100011106 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233100011107 NAD(P) binding site [chemical binding]; other site 1233100011108 catalytic residues [active] 1233100011109 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1233100011110 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100011111 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1233100011112 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1233100011113 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1233100011114 UDP-glucose 4-epimerase; Region: PLN02240 1233100011115 NAD binding site [chemical binding]; other site 1233100011116 homodimer interface [polypeptide binding]; other site 1233100011117 active site 1233100011118 substrate binding site [chemical binding]; other site 1233100011119 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1233100011120 substrate binding site [chemical binding]; other site 1233100011121 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100011122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100011123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233100011124 dimerization interface [polypeptide binding]; other site 1233100011125 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1233100011126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100011127 active site 1233100011128 phosphorylation site [posttranslational modification] 1233100011129 intermolecular recognition site; other site 1233100011130 dimerization interface [polypeptide binding]; other site 1233100011131 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1233100011132 DNA binding residues [nucleotide binding] 1233100011133 dimerization interface [polypeptide binding]; other site 1233100011134 peptidase T; Region: peptidase-T; TIGR01882 1233100011135 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1233100011136 metal binding site [ion binding]; metal-binding site 1233100011137 dimer interface [polypeptide binding]; other site 1233100011138 Tubby C 2; Region: Tub_2; cl02043 1233100011139 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1233100011140 substrate binding site [chemical binding]; other site 1233100011141 THF binding site; other site 1233100011142 zinc-binding site [ion binding]; other site 1233100011143 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1233100011144 substrate binding site [chemical binding]; other site 1233100011145 THF binding site; other site 1233100011146 zinc-binding site [ion binding]; other site 1233100011147 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1233100011148 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1233100011149 NAD binding site [chemical binding]; other site 1233100011150 homotetramer interface [polypeptide binding]; other site 1233100011151 homodimer interface [polypeptide binding]; other site 1233100011152 substrate binding site [chemical binding]; other site 1233100011153 active site 1233100011154 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1233100011155 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1233100011156 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1233100011157 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1233100011158 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1233100011159 S-adenosylmethionine binding site [chemical binding]; other site 1233100011160 nucleoside transporter; Region: nupC; TIGR00804 1233100011161 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1233100011162 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1233100011163 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1233100011164 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1233100011165 hydroperoxidase II; Provisional; Region: katE; PRK11249 1233100011166 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1233100011167 tetramer interface [polypeptide binding]; other site 1233100011168 heme binding pocket [chemical binding]; other site 1233100011169 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1233100011170 domain interactions; other site 1233100011171 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1233100011172 Citrate transporter; Region: CitMHS; pfam03600 1233100011173 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1233100011174 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1233100011175 active site 1233100011176 active site 1233100011177 catalytic residues [active] 1233100011178 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1233100011179 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1233100011180 PRD domain; Region: PRD; pfam00874 1233100011181 PRD domain; Region: PRD; pfam00874 1233100011182 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1233100011183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100011184 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1233100011185 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1233100011186 ATP binding site [chemical binding]; other site 1233100011187 Mg++ binding site [ion binding]; other site 1233100011188 motif III; other site 1233100011189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100011190 nucleotide binding region [chemical binding]; other site 1233100011191 ATP-binding site [chemical binding]; other site 1233100011192 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1233100011193 RNA binding site [nucleotide binding]; other site 1233100011194 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1233100011195 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1233100011196 active site 1233100011197 catalytic triad [active] 1233100011198 RHS Repeat; Region: RHS_repeat; pfam05593 1233100011199 RHS Repeat; Region: RHS_repeat; pfam05593 1233100011200 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1233100011201 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1233100011202 RHS Repeat; Region: RHS_repeat; pfam05593 1233100011203 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1233100011204 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1233100011205 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1233100011206 EamA-like transporter family; Region: EamA; pfam00892 1233100011207 EamA-like transporter family; Region: EamA; pfam00892 1233100011208 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1233100011209 Ligand Binding Site [chemical binding]; other site 1233100011210 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1233100011211 beta-galactosidase; Region: BGL; TIGR03356 1233100011212 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1233100011213 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1233100011214 HPr interaction site; other site 1233100011215 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1233100011216 active site 1233100011217 phosphorylation site [posttranslational modification] 1233100011218 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 1233100011219 LXG domain of WXG superfamily; Region: LXG; pfam04740 1233100011220 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1233100011221 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 1233100011222 PLD-like domain; Region: PLDc_2; pfam13091 1233100011223 putative homodimer interface [polypeptide binding]; other site 1233100011224 putative active site [active] 1233100011225 catalytic site [active] 1233100011226 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1233100011227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100011228 ATP binding site [chemical binding]; other site 1233100011229 putative Mg++ binding site [ion binding]; other site 1233100011230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1233100011231 nucleotide binding region [chemical binding]; other site 1233100011232 ATP-binding site [chemical binding]; other site 1233100011233 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1233100011234 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1233100011235 active site 1233100011236 8-oxo-dGMP binding site [chemical binding]; other site 1233100011237 nudix motif; other site 1233100011238 metal binding site [ion binding]; metal-binding site 1233100011239 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1233100011240 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1233100011241 substrate binding site [chemical binding]; other site 1233100011242 active site 1233100011243 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1233100011244 hexamer interface [polypeptide binding]; other site 1233100011245 RNA binding site [nucleotide binding]; other site 1233100011246 Histidine-zinc binding site [chemical binding]; other site 1233100011247 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1233100011248 active sites [active] 1233100011249 tetramer interface [polypeptide binding]; other site 1233100011250 urocanate hydratase; Provisional; Region: PRK05414 1233100011251 imidazolonepropionase; Validated; Region: PRK09356 1233100011252 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1233100011253 active site 1233100011254 Agmatinase-like family; Region: Agmatinase-like; cd09990 1233100011255 agmatinase; Region: agmatinase; TIGR01230 1233100011256 active site 1233100011257 oligomer interface [polypeptide binding]; other site 1233100011258 Mn binding site [ion binding]; other site 1233100011259 S-methylmethionine transporter; Provisional; Region: PRK11387 1233100011260 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1233100011261 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1233100011262 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1233100011263 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1233100011264 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1233100011265 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1233100011266 Nucleoside recognition; Region: Gate; pfam07670 1233100011267 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1233100011268 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1233100011269 intersubunit interface [polypeptide binding]; other site 1233100011270 active site 1233100011271 catalytic residue [active] 1233100011272 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1233100011273 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1233100011274 DNA binding residues [nucleotide binding] 1233100011275 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1233100011276 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1233100011277 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1233100011278 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1233100011279 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1233100011280 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 1233100011281 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1233100011282 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1233100011283 metal binding site [ion binding]; metal-binding site 1233100011284 dimer interface [polypeptide binding]; other site 1233100011285 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1233100011286 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1233100011287 Walker A/P-loop; other site 1233100011288 ATP binding site [chemical binding]; other site 1233100011289 Q-loop/lid; other site 1233100011290 ABC transporter signature motif; other site 1233100011291 Walker B; other site 1233100011292 D-loop; other site 1233100011293 H-loop/switch region; other site 1233100011294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1233100011295 dimer interface [polypeptide binding]; other site 1233100011296 conserved gate region; other site 1233100011297 putative PBP binding loops; other site 1233100011298 ABC-ATPase subunit interface; other site 1233100011299 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1233100011300 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1233100011301 substrate binding pocket [chemical binding]; other site 1233100011302 membrane-bound complex binding site; other site 1233100011303 hinge residues; other site 1233100011304 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1233100011305 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1233100011306 active site 1233100011307 non-prolyl cis peptide bond; other site 1233100011308 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1233100011309 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1233100011310 active site 1233100011311 sugar phosphate phosphatase; Provisional; Region: PRK10513 1233100011312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100011313 active site 1233100011314 motif I; other site 1233100011315 motif II; other site 1233100011316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1233100011317 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1233100011318 proteasome-activating nucleotidase; Provisional; Region: PRK03992 1233100011319 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1233100011320 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1233100011321 putative ligand binding residues [chemical binding]; other site 1233100011322 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1233100011323 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1233100011324 Walker A/P-loop; other site 1233100011325 ATP binding site [chemical binding]; other site 1233100011326 Q-loop/lid; other site 1233100011327 ABC transporter signature motif; other site 1233100011328 Walker B; other site 1233100011329 D-loop; other site 1233100011330 H-loop/switch region; other site 1233100011331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1233100011332 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1233100011333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100011334 ATP binding site [chemical binding]; other site 1233100011335 Mg2+ binding site [ion binding]; other site 1233100011336 G-X-G motif; other site 1233100011337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100011338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100011339 active site 1233100011340 phosphorylation site [posttranslational modification] 1233100011341 intermolecular recognition site; other site 1233100011342 dimerization interface [polypeptide binding]; other site 1233100011343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100011344 DNA binding site [nucleotide binding] 1233100011345 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1233100011346 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1233100011347 intersubunit interface [polypeptide binding]; other site 1233100011348 active site 1233100011349 zinc binding site [ion binding]; other site 1233100011350 Na+ binding site [ion binding]; other site 1233100011351 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1233100011352 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1233100011353 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1233100011354 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1233100011355 DNA interaction; other site 1233100011356 Metal-binding active site; metal-binding site 1233100011357 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1233100011358 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1233100011359 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1233100011360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100011361 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100011362 putative substrate translocation pore; other site 1233100011363 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1233100011364 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1233100011365 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1233100011366 PYR/PP interface [polypeptide binding]; other site 1233100011367 dimer interface [polypeptide binding]; other site 1233100011368 TPP binding site [chemical binding]; other site 1233100011369 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1233100011370 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1233100011371 TPP-binding site; other site 1233100011372 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1233100011373 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1233100011374 substrate binding site [chemical binding]; other site 1233100011375 ATP binding site [chemical binding]; other site 1233100011376 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1233100011377 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1233100011378 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1233100011379 tetrameric interface [polypeptide binding]; other site 1233100011380 NAD binding site [chemical binding]; other site 1233100011381 catalytic residues [active] 1233100011382 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1233100011383 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1233100011384 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1233100011385 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1233100011386 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1233100011387 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1233100011388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1233100011389 active site 1233100011390 catalytic tetrad [active] 1233100011391 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1233100011392 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1233100011393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100011394 putative substrate translocation pore; other site 1233100011395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100011396 heat shock protein 90; Provisional; Region: PRK05218 1233100011397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100011398 ATP binding site [chemical binding]; other site 1233100011399 Mg2+ binding site [ion binding]; other site 1233100011400 G-X-G motif; other site 1233100011401 short chain dehydrogenase; Validated; Region: PRK08589 1233100011402 classical (c) SDRs; Region: SDR_c; cd05233 1233100011403 NAD(P) binding site [chemical binding]; other site 1233100011404 active site 1233100011405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100011406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100011407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100011408 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1233100011409 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1233100011410 NAD(P) binding site [chemical binding]; other site 1233100011411 catalytic residues [active] 1233100011412 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1233100011413 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1233100011414 active site 1233100011415 Trp docking motif [polypeptide binding]; other site 1233100011416 RDD family; Region: RDD; pfam06271 1233100011417 Predicted membrane protein [Function unknown]; Region: COG2311 1233100011418 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1233100011419 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1233100011420 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1233100011421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1233100011422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1233100011423 short chain dehydrogenase; Provisional; Region: PRK07109 1233100011424 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1233100011425 putative NAD(P) binding site [chemical binding]; other site 1233100011426 active site 1233100011427 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100011428 MarR family; Region: MarR; pfam01047 1233100011429 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1233100011430 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1233100011431 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1233100011432 Glycerate kinase family; Region: Gly_kinase; pfam02595 1233100011433 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1233100011434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100011435 DNA-binding site [nucleotide binding]; DNA binding site 1233100011436 FCD domain; Region: FCD; pfam07729 1233100011437 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1233100011438 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1233100011439 N- and C-terminal domain interface [polypeptide binding]; other site 1233100011440 active site 1233100011441 catalytic site [active] 1233100011442 metal binding site [ion binding]; metal-binding site 1233100011443 carbohydrate binding site [chemical binding]; other site 1233100011444 ATP binding site [chemical binding]; other site 1233100011445 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1233100011446 gluconate transporter; Region: gntP; TIGR00791 1233100011447 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 1233100011448 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1233100011449 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1233100011450 peroxiredoxin; Region: AhpC; TIGR03137 1233100011451 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1233100011452 dimer interface [polypeptide binding]; other site 1233100011453 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1233100011454 catalytic triad [active] 1233100011455 peroxidatic and resolving cysteines [active] 1233100011456 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1233100011457 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1233100011458 catalytic residue [active] 1233100011459 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1233100011460 catalytic residues [active] 1233100011461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1233100011462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1233100011463 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1233100011464 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1233100011465 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1233100011466 beta-galactosidase; Region: BGL; TIGR03356 1233100011467 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1233100011468 active site turn [active] 1233100011469 phosphorylation site [posttranslational modification] 1233100011470 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1233100011471 HPr interaction site; other site 1233100011472 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1233100011473 active site 1233100011474 phosphorylation site [posttranslational modification] 1233100011475 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1233100011476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1233100011477 DNA-binding site [nucleotide binding]; DNA binding site 1233100011478 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1233100011479 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1233100011480 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1233100011481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1233100011482 Walker A/P-loop; other site 1233100011483 ATP binding site [chemical binding]; other site 1233100011484 ABC transporter signature motif; other site 1233100011485 Walker B; other site 1233100011486 D-loop; other site 1233100011487 H-loop/switch region; other site 1233100011488 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1233100011489 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1233100011490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1233100011491 ATP binding site [chemical binding]; other site 1233100011492 putative Mg++ binding site [ion binding]; other site 1233100011493 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1233100011494 DNA methylase; Region: N6_N4_Mtase; pfam01555 1233100011495 DNA methylase; Region: N6_N4_Mtase; cl17433 1233100011496 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1233100011497 Part of AAA domain; Region: AAA_19; pfam13245 1233100011498 Family description; Region: UvrD_C_2; pfam13538 1233100011499 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1233100011500 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1233100011501 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1233100011502 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1233100011503 NAD binding site [chemical binding]; other site 1233100011504 catalytic Zn binding site [ion binding]; other site 1233100011505 structural Zn binding site [ion binding]; other site 1233100011506 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1233100011507 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1233100011508 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1233100011509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100011510 Coenzyme A binding pocket [chemical binding]; other site 1233100011511 Arginase family; Region: Arginase; cd09989 1233100011512 agmatinase; Region: agmatinase; TIGR01230 1233100011513 active site 1233100011514 Mn binding site [ion binding]; other site 1233100011515 oligomer interface [polypeptide binding]; other site 1233100011516 S-methylmethionine transporter; Provisional; Region: PRK11387 1233100011517 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1233100011518 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1233100011519 inhibitor-cofactor binding pocket; inhibition site 1233100011520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1233100011521 catalytic residue [active] 1233100011522 PAS domain; Region: PAS; smart00091 1233100011523 PAS domain; Region: PAS_9; pfam13426 1233100011524 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1233100011525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1233100011526 Walker A motif; other site 1233100011527 ATP binding site [chemical binding]; other site 1233100011528 Walker B motif; other site 1233100011529 arginine finger; other site 1233100011530 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1233100011531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100011532 ATP binding site [chemical binding]; other site 1233100011533 G-X-G motif; other site 1233100011534 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1233100011535 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1233100011536 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1233100011537 protein binding site [polypeptide binding]; other site 1233100011538 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1233100011539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 1233100011540 YycH protein; Region: YycH; pfam07435 1233100011541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1233100011542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1233100011543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1233100011544 dimerization interface [polypeptide binding]; other site 1233100011545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1233100011546 putative active site [active] 1233100011547 heme pocket [chemical binding]; other site 1233100011548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1233100011549 dimer interface [polypeptide binding]; other site 1233100011550 phosphorylation site [posttranslational modification] 1233100011551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1233100011552 ATP binding site [chemical binding]; other site 1233100011553 Mg2+ binding site [ion binding]; other site 1233100011554 G-X-G motif; other site 1233100011555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1233100011556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1233100011557 active site 1233100011558 phosphorylation site [posttranslational modification] 1233100011559 intermolecular recognition site; other site 1233100011560 dimerization interface [polypeptide binding]; other site 1233100011561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1233100011562 DNA binding site [nucleotide binding] 1233100011563 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1233100011564 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1233100011565 GDP-binding site [chemical binding]; other site 1233100011566 ACT binding site; other site 1233100011567 IMP binding site; other site 1233100011568 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100011569 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1233100011570 active site 1233100011571 replicative DNA helicase; Provisional; Region: PRK05748 1233100011572 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1233100011573 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1233100011574 Walker A motif; other site 1233100011575 ATP binding site [chemical binding]; other site 1233100011576 Walker B motif; other site 1233100011577 DNA binding loops [nucleotide binding] 1233100011578 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1233100011579 YycC-like protein; Region: YycC; pfam14174 1233100011580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100011581 cyanate transporter; Region: CynX; TIGR00896 1233100011582 putative substrate translocation pore; other site 1233100011583 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1233100011584 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1233100011585 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1233100011586 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1233100011587 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1233100011588 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1233100011589 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1233100011590 diguanylate cyclase; Region: GGDEF; smart00267 1233100011591 DHH family; Region: DHH; pfam01368 1233100011592 DHHA1 domain; Region: DHHA1; pfam02272 1233100011593 Predicted membrane protein [Function unknown]; Region: COG4241 1233100011594 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1233100011595 Predicted transcriptional regulators [Transcription]; Region: COG1733 1233100011596 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1233100011597 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1233100011598 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1233100011599 DHHA2 domain; Region: DHHA2; pfam02833 1233100011600 ANTAR domain; Region: ANTAR; cl04297 1233100011601 D-galactonate transporter; Region: 2A0114; TIGR00893 1233100011602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100011603 putative substrate translocation pore; other site 1233100011604 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1233100011605 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1233100011606 DNA binding residues [nucleotide binding] 1233100011607 dimer interface [polypeptide binding]; other site 1233100011608 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1233100011609 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1233100011610 SnoaL-like domain; Region: SnoaL_3; pfam13474 1233100011611 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1233100011612 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1233100011613 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1233100011614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100011615 putative substrate translocation pore; other site 1233100011616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1233100011617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100011618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100011619 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1233100011620 putative dimerization interface [polypeptide binding]; other site 1233100011621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100011622 Coenzyme A binding pocket [chemical binding]; other site 1233100011623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1233100011624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1233100011625 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1233100011626 dimerization interface [polypeptide binding]; other site 1233100011627 LysE type translocator; Region: LysE; cl00565 1233100011628 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1233100011629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100011630 active site 1233100011631 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1233100011632 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1233100011633 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1233100011634 MarR family; Region: MarR; pfam01047 1233100011635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100011636 Coenzyme A binding pocket [chemical binding]; other site 1233100011637 Predicted membrane protein [Function unknown]; Region: COG2364 1233100011638 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1233100011639 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1233100011640 Coenzyme A binding pocket [chemical binding]; other site 1233100011641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1233100011642 RibD C-terminal domain; Region: RibD_C; cl17279 1233100011643 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1233100011644 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1233100011645 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1233100011646 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1233100011647 active site 1233100011648 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1233100011649 arsenical-resistance protein; Region: acr3; TIGR00832 1233100011650 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1233100011651 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100011652 putative metal binding site [ion binding]; other site 1233100011653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1233100011654 dimerization interface [polypeptide binding]; other site 1233100011655 putative DNA binding site [nucleotide binding]; other site 1233100011656 putative Zn2+ binding site [ion binding]; other site 1233100011657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1233100011658 salt bridge; other site 1233100011659 non-specific DNA binding site [nucleotide binding]; other site 1233100011660 sequence-specific DNA binding site [nucleotide binding]; other site 1233100011661 DNA methylase; Region: N6_N4_Mtase; cl17433 1233100011662 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1233100011663 Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549 1233100011664 CAAX protease self-immunity; Region: Abi; pfam02517 1233100011665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1233100011666 maltose O-acetyltransferase; Provisional; Region: PRK10092 1233100011667 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1233100011668 active site 1233100011669 substrate binding site [chemical binding]; other site 1233100011670 trimer interface [polypeptide binding]; other site 1233100011671 CoA binding site [chemical binding]; other site 1233100011672 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1233100011673 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1233100011674 putative metal binding site [ion binding]; other site 1233100011675 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1233100011676 DNA binding site [nucleotide binding] 1233100011677 domain linker motif; other site 1233100011678 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1233100011679 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1233100011680 putative dimerization interface [polypeptide binding]; other site 1233100011681 putative ligand binding site [chemical binding]; other site 1233100011682 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1233100011683 active site 1233100011684 putative catalytic site [active] 1233100011685 DNA binding site [nucleotide binding] 1233100011686 putative phosphate binding site [ion binding]; other site 1233100011687 metal binding site A [ion binding]; metal-binding site 1233100011688 AP binding site [nucleotide binding]; other site 1233100011689 metal binding site B [ion binding]; metal-binding site 1233100011690 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1233100011691 GTP-binding protein YchF; Reviewed; Region: PRK09601 1233100011692 YchF GTPase; Region: YchF; cd01900 1233100011693 G1 box; other site 1233100011694 GTP/Mg2+ binding site [chemical binding]; other site 1233100011695 Switch I region; other site 1233100011696 G2 box; other site 1233100011697 Switch II region; other site 1233100011698 G3 box; other site 1233100011699 G4 box; other site 1233100011700 G5 box; other site 1233100011701 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1233100011702 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1233100011703 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1233100011704 putative [4Fe-4S] binding site [ion binding]; other site 1233100011705 putative molybdopterin cofactor binding site [chemical binding]; other site 1233100011706 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1233100011707 molybdopterin cofactor binding site; other site 1233100011708 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1233100011709 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1233100011710 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1233100011711 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1233100011712 ParB-like nuclease domain; Region: ParB; smart00470 1233100011713 KorB domain; Region: KorB; pfam08535 1233100011714 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1233100011715 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1233100011716 P-loop; other site 1233100011717 Magnesium ion binding site [ion binding]; other site 1233100011718 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1233100011719 Magnesium ion binding site [ion binding]; other site 1233100011720 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1233100011721 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1233100011722 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1233100011723 ParB-like nuclease domain; Region: ParB; smart00470 1233100011724 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1233100011725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1233100011726 S-adenosylmethionine binding site [chemical binding]; other site 1233100011727 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1233100011728 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1233100011729 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1233100011730 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1233100011731 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1233100011732 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1233100011733 G1 box; other site 1233100011734 GTP/Mg2+ binding site [chemical binding]; other site 1233100011735 Switch I region; other site 1233100011736 G2 box; other site 1233100011737 Switch II region; other site 1233100011738 G3 box; other site 1233100011739 G4 box; other site 1233100011740 G5 box; other site 1233100011741 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1233100011742 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1233100011743 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1233100011744 G-X-X-G motif; other site 1233100011745 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1233100011746 RxxxH motif; other site 1233100011747 OxaA-like protein precursor; Validated; Region: PRK02944 1233100011748 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1233100011749 ribonuclease P; Reviewed; Region: rnpA; PRK00499