-- dump date 20140618_225312 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1220533000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1220533000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1220533000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533000004 Walker A motif; other site 1220533000005 ATP binding site [chemical binding]; other site 1220533000006 Walker B motif; other site 1220533000007 arginine finger; other site 1220533000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1220533000009 DnaA box-binding interface [nucleotide binding]; other site 1220533000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1220533000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1220533000012 putative DNA binding surface [nucleotide binding]; other site 1220533000013 dimer interface [polypeptide binding]; other site 1220533000014 beta-clamp/clamp loader binding surface; other site 1220533000015 beta-clamp/translesion DNA polymerase binding surface; other site 1220533000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1220533000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1220533000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1220533000019 Walker A/P-loop; other site 1220533000020 ATP binding site [chemical binding]; other site 1220533000021 Q-loop/lid; other site 1220533000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1220533000023 ABC transporter signature motif; other site 1220533000024 Walker B; other site 1220533000025 D-loop; other site 1220533000026 H-loop/switch region; other site 1220533000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1220533000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533000029 ATP binding site [chemical binding]; other site 1220533000030 Mg2+ binding site [ion binding]; other site 1220533000031 G-X-G motif; other site 1220533000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1220533000033 anchoring element; other site 1220533000034 dimer interface [polypeptide binding]; other site 1220533000035 ATP binding site [chemical binding]; other site 1220533000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1220533000037 active site 1220533000038 putative metal-binding site [ion binding]; other site 1220533000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1220533000040 DNA gyrase subunit A; Validated; Region: PRK05560 1220533000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1220533000042 CAP-like domain; other site 1220533000043 active site 1220533000044 primary dimer interface [polypeptide binding]; other site 1220533000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533000051 YaaC-like Protein; Region: YaaC; pfam14175 1220533000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1220533000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1220533000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1220533000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1220533000056 active site 1220533000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1220533000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1220533000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1220533000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1220533000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1220533000062 active site 1220533000063 multimer interface [polypeptide binding]; other site 1220533000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1220533000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1220533000066 predicted active site [active] 1220533000067 catalytic triad [active] 1220533000068 T-box; B657_miscRNA1 1220533000069 seryl-tRNA synthetase; Provisional; Region: PRK05431 1220533000070 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1220533000071 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1220533000072 dimer interface [polypeptide binding]; other site 1220533000073 active site 1220533000074 motif 1; other site 1220533000075 motif 2; other site 1220533000076 motif 3; other site 1220533000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1220533000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1220533000079 Substrate-binding site [chemical binding]; other site 1220533000080 Substrate specificity [chemical binding]; other site 1220533000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1220533000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1220533000083 Substrate-binding site [chemical binding]; other site 1220533000084 Substrate specificity [chemical binding]; other site 1220533000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1220533000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1220533000089 active site 1220533000090 Isochorismatase family; Region: Isochorismatase; pfam00857 1220533000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1220533000092 catalytic triad [active] 1220533000093 conserved cis-peptide bond; other site 1220533000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1220533000095 nucleoside/Zn binding site; other site 1220533000096 dimer interface [polypeptide binding]; other site 1220533000097 catalytic motif [active] 1220533000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1220533000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533000100 Walker A motif; other site 1220533000101 ATP binding site [chemical binding]; other site 1220533000102 Walker B motif; other site 1220533000103 arginine finger; other site 1220533000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1220533000105 hypothetical protein; Validated; Region: PRK00153 1220533000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 1220533000107 RecR protein; Region: RecR; pfam02132 1220533000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1220533000109 putative active site [active] 1220533000110 putative metal-binding site [ion binding]; other site 1220533000111 tetramer interface [polypeptide binding]; other site 1220533000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1220533000113 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1220533000114 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1220533000115 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1220533000116 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1220533000117 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 1220533000118 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1220533000119 homodimer interface [polypeptide binding]; other site 1220533000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533000121 catalytic residue [active] 1220533000122 thymidylate kinase; Validated; Region: tmk; PRK00698 1220533000123 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1220533000124 TMP-binding site; other site 1220533000125 ATP-binding site [chemical binding]; other site 1220533000126 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1220533000127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 1220533000128 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1220533000129 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1220533000130 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1220533000131 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1220533000132 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1220533000133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533000134 S-adenosylmethionine binding site [chemical binding]; other site 1220533000135 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1220533000136 GIY-YIG motif/motif A; other site 1220533000137 putative active site [active] 1220533000138 putative metal binding site [ion binding]; other site 1220533000139 Predicted methyltransferases [General function prediction only]; Region: COG0313 1220533000140 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1220533000141 putative SAM binding site [chemical binding]; other site 1220533000142 putative homodimer interface [polypeptide binding]; other site 1220533000143 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1220533000144 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1220533000145 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1220533000146 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1220533000147 active site 1220533000148 HIGH motif; other site 1220533000149 KMSKS motif; other site 1220533000150 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1220533000151 tRNA binding surface [nucleotide binding]; other site 1220533000152 anticodon binding site; other site 1220533000153 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1220533000154 dimer interface [polypeptide binding]; other site 1220533000155 putative tRNA-binding site [nucleotide binding]; other site 1220533000156 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1220533000157 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1220533000158 active site 1220533000159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1220533000160 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1220533000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1220533000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1220533000163 G5 domain; Region: G5; pfam07501 1220533000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1220533000165 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1220533000166 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1220533000167 putative active site [active] 1220533000168 putative metal binding site [ion binding]; other site 1220533000169 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1220533000170 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1220533000171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533000172 S-adenosylmethionine binding site [chemical binding]; other site 1220533000173 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1220533000174 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1220533000175 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1220533000176 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1220533000177 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1220533000178 pur operon repressor; Provisional; Region: PRK09213 1220533000179 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1220533000180 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533000181 active site 1220533000182 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1220533000183 homotrimer interaction site [polypeptide binding]; other site 1220533000184 putative active site [active] 1220533000185 regulatory protein SpoVG; Reviewed; Region: PRK13259 1220533000186 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1220533000187 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1220533000188 Substrate binding site; other site 1220533000189 Mg++ binding site; other site 1220533000190 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1220533000191 active site 1220533000192 substrate binding site [chemical binding]; other site 1220533000193 CoA binding site [chemical binding]; other site 1220533000194 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1220533000195 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1220533000196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533000197 active site 1220533000198 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1220533000199 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1220533000200 5S rRNA interface [nucleotide binding]; other site 1220533000201 CTC domain interface [polypeptide binding]; other site 1220533000202 L16 interface [polypeptide binding]; other site 1220533000203 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1220533000204 putative active site [active] 1220533000205 catalytic residue [active] 1220533000206 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1220533000207 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1220533000208 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1220533000209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533000210 ATP binding site [chemical binding]; other site 1220533000211 putative Mg++ binding site [ion binding]; other site 1220533000212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533000213 nucleotide binding region [chemical binding]; other site 1220533000214 ATP-binding site [chemical binding]; other site 1220533000215 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1220533000216 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1220533000217 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1220533000218 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1220533000219 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1220533000220 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1220533000221 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1220533000222 putative SAM binding site [chemical binding]; other site 1220533000223 putative homodimer interface [polypeptide binding]; other site 1220533000224 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1220533000225 homodimer interface [polypeptide binding]; other site 1220533000226 metal binding site [ion binding]; metal-binding site 1220533000227 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1220533000228 homodimer interface [polypeptide binding]; other site 1220533000229 active site 1220533000230 putative chemical substrate binding site [chemical binding]; other site 1220533000231 metal binding site [ion binding]; metal-binding site 1220533000232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533000233 RNA binding surface [nucleotide binding]; other site 1220533000234 sporulation protein YabP; Region: spore_yabP; TIGR02892 1220533000235 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1220533000236 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1220533000237 Septum formation initiator; Region: DivIC; pfam04977 1220533000238 hypothetical protein; Provisional; Region: PRK08582 1220533000239 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1220533000240 RNA binding site [nucleotide binding]; other site 1220533000241 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1220533000242 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1220533000243 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1220533000244 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1220533000245 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1220533000246 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1220533000247 metal ion-dependent adhesion site (MIDAS); other site 1220533000248 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1220533000249 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1220533000250 active site 1220533000251 ATP binding site [chemical binding]; other site 1220533000252 substrate binding site [chemical binding]; other site 1220533000253 activation loop (A-loop); other site 1220533000254 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1220533000255 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1220533000256 Ligand Binding Site [chemical binding]; other site 1220533000257 TilS substrate binding domain; Region: TilS; pfam09179 1220533000258 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1220533000259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533000260 active site 1220533000261 FtsH Extracellular; Region: FtsH_ext; pfam06480 1220533000262 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1220533000263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533000264 Walker A motif; other site 1220533000265 ATP binding site [chemical binding]; other site 1220533000266 Walker B motif; other site 1220533000267 arginine finger; other site 1220533000268 Peptidase family M41; Region: Peptidase_M41; pfam01434 1220533000269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1220533000270 nucleotide binding site [chemical binding]; other site 1220533000271 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1220533000272 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1220533000273 dimerization interface [polypeptide binding]; other site 1220533000274 domain crossover interface; other site 1220533000275 redox-dependent activation switch; other site 1220533000276 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1220533000277 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1220533000278 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1220533000279 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1220533000280 dimer interface [polypeptide binding]; other site 1220533000281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533000282 catalytic residue [active] 1220533000283 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1220533000284 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1220533000285 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1220533000286 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1220533000287 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1220533000288 glutamine binding [chemical binding]; other site 1220533000289 catalytic triad [active] 1220533000290 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1220533000291 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1220533000292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533000293 catalytic residue [active] 1220533000294 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1220533000295 dihydropteroate synthase; Region: DHPS; TIGR01496 1220533000296 substrate binding pocket [chemical binding]; other site 1220533000297 dimer interface [polypeptide binding]; other site 1220533000298 inhibitor binding site; inhibition site 1220533000299 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1220533000300 homooctamer interface [polypeptide binding]; other site 1220533000301 active site 1220533000302 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1220533000303 catalytic center binding site [active] 1220533000304 ATP binding site [chemical binding]; other site 1220533000305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533000306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533000307 non-specific DNA binding site [nucleotide binding]; other site 1220533000308 salt bridge; other site 1220533000309 sequence-specific DNA binding site [nucleotide binding]; other site 1220533000310 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1220533000311 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1220533000312 FMN binding site [chemical binding]; other site 1220533000313 active site 1220533000314 catalytic residues [active] 1220533000315 substrate binding site [chemical binding]; other site 1220533000316 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1220533000317 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1220533000318 dimer interface [polypeptide binding]; other site 1220533000319 putative anticodon binding site; other site 1220533000320 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1220533000321 motif 1; other site 1220533000322 active site 1220533000323 motif 2; other site 1220533000324 motif 3; other site 1220533000325 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1220533000326 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1220533000327 UvrB/uvrC motif; Region: UVR; pfam02151 1220533000328 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1220533000329 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1220533000330 ADP binding site [chemical binding]; other site 1220533000331 phosphagen binding site; other site 1220533000332 substrate specificity loop; other site 1220533000333 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1220533000334 Clp amino terminal domain; Region: Clp_N; pfam02861 1220533000335 Clp amino terminal domain; Region: Clp_N; pfam02861 1220533000336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533000337 Walker A motif; other site 1220533000338 ATP binding site [chemical binding]; other site 1220533000339 Walker B motif; other site 1220533000340 arginine finger; other site 1220533000341 UvrB/uvrC motif; Region: UVR; pfam02151 1220533000342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533000343 Walker A motif; other site 1220533000344 ATP binding site [chemical binding]; other site 1220533000345 Walker B motif; other site 1220533000346 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1220533000347 DNA repair protein RadA; Provisional; Region: PRK11823 1220533000348 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1220533000349 Walker A motif/ATP binding site; other site 1220533000350 ATP binding site [chemical binding]; other site 1220533000351 Walker B motif; other site 1220533000352 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1220533000353 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1220533000354 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1220533000355 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1220533000356 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1220533000357 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1220533000358 putative active site [active] 1220533000359 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1220533000360 substrate binding site; other site 1220533000361 dimer interface; other site 1220533000362 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1220533000363 homotrimer interaction site [polypeptide binding]; other site 1220533000364 zinc binding site [ion binding]; other site 1220533000365 CDP-binding sites; other site 1220533000366 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1220533000367 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1220533000368 active site 1220533000369 HIGH motif; other site 1220533000370 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1220533000371 active site 1220533000372 KMSKS motif; other site 1220533000373 serine O-acetyltransferase; Region: cysE; TIGR01172 1220533000374 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1220533000375 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1220533000376 trimer interface [polypeptide binding]; other site 1220533000377 active site 1220533000378 substrate binding site [chemical binding]; other site 1220533000379 CoA binding site [chemical binding]; other site 1220533000380 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1220533000381 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1220533000382 active site 1220533000383 HIGH motif; other site 1220533000384 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1220533000385 KMSKS motif; other site 1220533000386 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1220533000387 tRNA binding surface [nucleotide binding]; other site 1220533000388 anticodon binding site; other site 1220533000389 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1220533000390 active site 1220533000391 metal binding site [ion binding]; metal-binding site 1220533000392 dimerization interface [polypeptide binding]; other site 1220533000393 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1220533000394 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1220533000395 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1220533000396 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1220533000397 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1220533000398 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533000399 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1220533000400 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1220533000401 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1220533000402 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1220533000403 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1220533000404 23S rRNA interface [nucleotide binding]; other site 1220533000405 L7/L12 interface [polypeptide binding]; other site 1220533000406 putative thiostrepton binding site; other site 1220533000407 L25 interface [polypeptide binding]; other site 1220533000408 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1220533000409 mRNA/rRNA interface [nucleotide binding]; other site 1220533000410 L10_leader; B657_miscRNA3 1220533000411 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1220533000412 23S rRNA interface [nucleotide binding]; other site 1220533000413 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1220533000414 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1220533000415 core dimer interface [polypeptide binding]; other site 1220533000416 peripheral dimer interface [polypeptide binding]; other site 1220533000417 L10 interface [polypeptide binding]; other site 1220533000418 L11 interface [polypeptide binding]; other site 1220533000419 putative EF-Tu interaction site [polypeptide binding]; other site 1220533000420 putative EF-G interaction site [polypeptide binding]; other site 1220533000421 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1220533000422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533000423 S-adenosylmethionine binding site [chemical binding]; other site 1220533000424 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1220533000425 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1220533000426 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1220533000427 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1220533000428 RPB1 interaction site [polypeptide binding]; other site 1220533000429 RPB10 interaction site [polypeptide binding]; other site 1220533000430 RPB11 interaction site [polypeptide binding]; other site 1220533000431 RPB3 interaction site [polypeptide binding]; other site 1220533000432 RPB12 interaction site [polypeptide binding]; other site 1220533000433 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1220533000434 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1220533000435 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1220533000436 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1220533000437 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1220533000438 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1220533000439 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1220533000440 G-loop; other site 1220533000441 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1220533000442 DNA binding site [nucleotide binding] 1220533000443 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1220533000444 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1220533000445 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1220533000446 S17 interaction site [polypeptide binding]; other site 1220533000447 S8 interaction site; other site 1220533000448 16S rRNA interaction site [nucleotide binding]; other site 1220533000449 streptomycin interaction site [chemical binding]; other site 1220533000450 23S rRNA interaction site [nucleotide binding]; other site 1220533000451 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1220533000452 30S ribosomal protein S7; Validated; Region: PRK05302 1220533000453 elongation factor G; Reviewed; Region: PRK00007 1220533000454 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1220533000455 G1 box; other site 1220533000456 putative GEF interaction site [polypeptide binding]; other site 1220533000457 GTP/Mg2+ binding site [chemical binding]; other site 1220533000458 Switch I region; other site 1220533000459 G2 box; other site 1220533000460 G3 box; other site 1220533000461 Switch II region; other site 1220533000462 G4 box; other site 1220533000463 G5 box; other site 1220533000464 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1220533000465 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1220533000466 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1220533000467 elongation factor Tu; Reviewed; Region: PRK00049 1220533000468 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1220533000469 G1 box; other site 1220533000470 GEF interaction site [polypeptide binding]; other site 1220533000471 GTP/Mg2+ binding site [chemical binding]; other site 1220533000472 Switch I region; other site 1220533000473 G2 box; other site 1220533000474 G3 box; other site 1220533000475 Switch II region; other site 1220533000476 G4 box; other site 1220533000477 G5 box; other site 1220533000478 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1220533000479 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1220533000480 Antibiotic Binding Site [chemical binding]; other site 1220533000481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533000482 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1220533000483 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1220533000484 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1220533000485 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1220533000486 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1220533000487 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1220533000488 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1220533000489 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1220533000490 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1220533000491 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1220533000492 putative translocon binding site; other site 1220533000493 protein-rRNA interface [nucleotide binding]; other site 1220533000494 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1220533000495 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1220533000496 G-X-X-G motif; other site 1220533000497 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1220533000498 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1220533000499 23S rRNA interface [nucleotide binding]; other site 1220533000500 5S rRNA interface [nucleotide binding]; other site 1220533000501 putative antibiotic binding site [chemical binding]; other site 1220533000502 L25 interface [polypeptide binding]; other site 1220533000503 L27 interface [polypeptide binding]; other site 1220533000504 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1220533000505 23S rRNA interface [nucleotide binding]; other site 1220533000506 putative translocon interaction site; other site 1220533000507 signal recognition particle (SRP54) interaction site; other site 1220533000508 L23 interface [polypeptide binding]; other site 1220533000509 trigger factor interaction site; other site 1220533000510 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1220533000511 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1220533000512 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1220533000513 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1220533000514 RNA binding site [nucleotide binding]; other site 1220533000515 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1220533000516 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1220533000517 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1220533000518 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1220533000519 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1220533000520 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1220533000521 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1220533000522 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1220533000523 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1220533000524 5S rRNA interface [nucleotide binding]; other site 1220533000525 L27 interface [polypeptide binding]; other site 1220533000526 23S rRNA interface [nucleotide binding]; other site 1220533000527 L5 interface [polypeptide binding]; other site 1220533000528 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1220533000529 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1220533000530 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1220533000531 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1220533000532 23S rRNA binding site [nucleotide binding]; other site 1220533000533 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1220533000534 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1220533000535 SecY translocase; Region: SecY; pfam00344 1220533000536 adenylate kinase; Reviewed; Region: adk; PRK00279 1220533000537 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1220533000538 AMP-binding site [chemical binding]; other site 1220533000539 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1220533000540 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1220533000541 active site 1220533000542 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1220533000543 RNA binding site [nucleotide binding]; other site 1220533000544 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1220533000545 rRNA binding site [nucleotide binding]; other site 1220533000546 predicted 30S ribosome binding site; other site 1220533000547 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1220533000548 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1220533000549 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1220533000550 30S ribosomal protein S11; Validated; Region: PRK05309 1220533000551 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1220533000552 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1220533000553 alphaNTD homodimer interface [polypeptide binding]; other site 1220533000554 alphaNTD - beta interaction site [polypeptide binding]; other site 1220533000555 alphaNTD - beta' interaction site [polypeptide binding]; other site 1220533000556 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1220533000557 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1220533000558 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1220533000559 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1220533000560 Walker A/P-loop; other site 1220533000561 ATP binding site [chemical binding]; other site 1220533000562 Q-loop/lid; other site 1220533000563 ABC transporter signature motif; other site 1220533000564 Walker B; other site 1220533000565 D-loop; other site 1220533000566 H-loop/switch region; other site 1220533000567 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1220533000568 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1220533000569 Walker A/P-loop; other site 1220533000570 ATP binding site [chemical binding]; other site 1220533000571 Q-loop/lid; other site 1220533000572 ABC transporter signature motif; other site 1220533000573 Walker B; other site 1220533000574 D-loop; other site 1220533000575 H-loop/switch region; other site 1220533000576 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1220533000577 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1220533000578 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1220533000579 dimerization interface 3.5A [polypeptide binding]; other site 1220533000580 active site 1220533000581 L13_leader; B657_miscRNA4 1220533000582 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1220533000583 23S rRNA interface [nucleotide binding]; other site 1220533000584 L3 interface [polypeptide binding]; other site 1220533000585 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1220533000586 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1220533000587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533000588 S-adenosylmethionine binding site [chemical binding]; other site 1220533000589 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1220533000590 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1220533000591 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1220533000592 active site 1220533000593 metal binding site [ion binding]; metal-binding site 1220533000594 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1220533000595 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1220533000596 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1220533000597 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1220533000598 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1220533000599 NodB motif; other site 1220533000600 putative active site [active] 1220533000601 putative catalytic site [active] 1220533000602 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1220533000603 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1220533000604 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1220533000605 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1220533000606 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1220533000607 Sodium Bile acid symporter family; Region: SBF; cl17470 1220533000608 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1220533000609 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1220533000610 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533000611 dimer interface [polypeptide binding]; other site 1220533000612 putative PBP binding regions; other site 1220533000613 ABC-ATPase subunit interface; other site 1220533000614 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1220533000615 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1220533000616 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533000617 ABC-ATPase subunit interface; other site 1220533000618 dimer interface [polypeptide binding]; other site 1220533000619 putative PBP binding regions; other site 1220533000620 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1220533000621 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1220533000622 putative ligand binding residues [chemical binding]; other site 1220533000623 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533000624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533000625 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1220533000626 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1220533000627 putative ligand binding residues [chemical binding]; other site 1220533000628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 1220533000629 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1220533000630 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1220533000631 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1220533000632 putative periplasmic esterase; Provisional; Region: PRK03642 1220533000633 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1220533000634 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1220533000635 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1220533000636 active site turn [active] 1220533000637 phosphorylation site [posttranslational modification] 1220533000638 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1220533000639 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1220533000640 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1220533000641 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1220533000642 putative active site [active] 1220533000643 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 1220533000644 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1220533000645 putative active site [active] 1220533000646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1220533000647 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1220533000648 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1220533000649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533000650 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533000651 DNA binding residues [nucleotide binding] 1220533000652 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1220533000653 Putative zinc-finger; Region: zf-HC2; pfam13490 1220533000654 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1220533000655 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1220533000656 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1220533000657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1220533000658 YbbR-like protein; Region: YbbR; pfam07949 1220533000659 YbbR-like protein; Region: YbbR; pfam07949 1220533000660 YbbR-like protein; Region: YbbR; pfam07949 1220533000661 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1220533000662 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1220533000663 active site 1220533000664 substrate binding site [chemical binding]; other site 1220533000665 metal binding site [ion binding]; metal-binding site 1220533000666 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1220533000667 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1220533000668 glutaminase active site [active] 1220533000669 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1220533000670 dimer interface [polypeptide binding]; other site 1220533000671 active site 1220533000672 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1220533000673 dimer interface [polypeptide binding]; other site 1220533000674 active site 1220533000675 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1220533000676 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1220533000677 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1220533000678 minor groove reading motif; other site 1220533000679 helix-hairpin-helix signature motif; other site 1220533000680 substrate binding pocket [chemical binding]; other site 1220533000681 active site 1220533000682 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1220533000683 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1220533000684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533000685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533000686 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1220533000687 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1220533000688 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1220533000689 DNA binding site [nucleotide binding] 1220533000690 active site 1220533000691 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1220533000692 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1220533000693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1220533000694 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1220533000695 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1220533000696 zinc binding site [ion binding]; other site 1220533000697 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1220533000698 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533000699 dimerization interface [polypeptide binding]; other site 1220533000700 putative DNA binding site [nucleotide binding]; other site 1220533000701 putative Zn2+ binding site [ion binding]; other site 1220533000702 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1220533000703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533000704 putative substrate translocation pore; other site 1220533000705 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 1220533000706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533000707 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1220533000708 FeS/SAM binding site; other site 1220533000709 CAAX protease self-immunity; Region: Abi; pfam02517 1220533000710 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1220533000711 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1220533000712 Walker A/P-loop; other site 1220533000713 ATP binding site [chemical binding]; other site 1220533000714 Q-loop/lid; other site 1220533000715 ABC transporter signature motif; other site 1220533000716 Walker B; other site 1220533000717 D-loop; other site 1220533000718 H-loop/switch region; other site 1220533000719 HEAT repeats; Region: HEAT_2; pfam13646 1220533000720 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1220533000721 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1220533000722 catalytic residues [active] 1220533000723 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533000724 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533000725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533000726 active site 1220533000727 phosphorylation site [posttranslational modification] 1220533000728 intermolecular recognition site; other site 1220533000729 dimerization interface [polypeptide binding]; other site 1220533000730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533000731 DNA binding site [nucleotide binding] 1220533000732 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1220533000733 active site 1220533000734 ATP binding site [chemical binding]; other site 1220533000735 substrate binding site [chemical binding]; other site 1220533000736 activation loop (A-loop); other site 1220533000737 putative transport protein YifK; Provisional; Region: PRK10746 1220533000738 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1220533000739 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1220533000740 Cytochrome P450; Region: p450; cl12078 1220533000741 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1220533000742 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1220533000743 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1220533000744 active site 1220533000745 catalytic site [active] 1220533000746 metal binding site [ion binding]; metal-binding site 1220533000747 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1220533000748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533000749 putative substrate translocation pore; other site 1220533000750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533000751 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1220533000752 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533000753 MarR family; Region: MarR; pfam01047 1220533000754 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1220533000755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533000756 Coenzyme A binding pocket [chemical binding]; other site 1220533000757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533000758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533000759 putative substrate translocation pore; other site 1220533000760 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1220533000761 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1220533000762 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1220533000763 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1220533000764 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1220533000765 active site 1220533000766 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1220533000767 EamA-like transporter family; Region: EamA; pfam00892 1220533000768 EamA-like transporter family; Region: EamA; pfam00892 1220533000769 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1220533000770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533000771 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533000772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533000773 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1220533000774 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1220533000775 ATP-grasp domain; Region: ATP-grasp; pfam02222 1220533000776 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1220533000777 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1220533000778 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533000779 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1220533000780 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1220533000781 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1220533000782 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1220533000783 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1220533000784 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1220533000785 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533000786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533000787 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1220533000788 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1220533000789 active site residue [active] 1220533000790 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1220533000791 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1220533000792 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1220533000793 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1220533000794 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1220533000795 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1220533000796 active site turn [active] 1220533000797 phosphorylation site [posttranslational modification] 1220533000798 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1220533000799 HPr interaction site; other site 1220533000800 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1220533000801 active site 1220533000802 phosphorylation site [posttranslational modification] 1220533000803 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1220533000804 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1220533000805 active site 1220533000806 trimer interface [polypeptide binding]; other site 1220533000807 allosteric site; other site 1220533000808 active site lid [active] 1220533000809 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1220533000810 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1220533000811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533000812 DNA-binding site [nucleotide binding]; DNA binding site 1220533000813 UTRA domain; Region: UTRA; pfam07702 1220533000814 Predicted integral membrane protein [Function unknown]; Region: COG5658 1220533000815 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1220533000816 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1220533000817 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1220533000818 homodimer interface [polypeptide binding]; other site 1220533000819 substrate-cofactor binding pocket; other site 1220533000820 catalytic residue [active] 1220533000821 S-methylmethionine transporter; Provisional; Region: PRK11387 1220533000822 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1220533000823 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1220533000824 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1220533000825 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1220533000826 glutaminase; Reviewed; Region: PRK12357 1220533000827 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1220533000828 Chorismate mutase type II; Region: CM_2; cl00693 1220533000829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533000830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533000831 ATP binding site [chemical binding]; other site 1220533000832 Mg2+ binding site [ion binding]; other site 1220533000833 G-X-G motif; other site 1220533000834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533000835 Response regulator receiver domain; Region: Response_reg; pfam00072 1220533000836 active site 1220533000837 phosphorylation site [posttranslational modification] 1220533000838 intermolecular recognition site; other site 1220533000839 dimerization interface [polypeptide binding]; other site 1220533000840 YcbB domain; Region: YcbB; pfam08664 1220533000841 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1220533000842 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1220533000843 putative active site [active] 1220533000844 catalytic residue [active] 1220533000845 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1220533000846 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1220533000847 NAD(P) binding site [chemical binding]; other site 1220533000848 catalytic residues [active] 1220533000849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533000850 D-galactonate transporter; Region: 2A0114; TIGR00893 1220533000851 putative substrate translocation pore; other site 1220533000852 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1220533000853 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1220533000854 active site 1220533000855 tetramer interface [polypeptide binding]; other site 1220533000856 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1220533000857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533000858 DNA-binding site [nucleotide binding]; DNA binding site 1220533000859 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1220533000860 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1220533000861 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1220533000862 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1220533000863 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1220533000864 putative active site [active] 1220533000865 putative substrate binding site [chemical binding]; other site 1220533000866 Phosphotransferase enzyme family; Region: APH; pfam01636 1220533000867 ATP binding site [chemical binding]; other site 1220533000868 T-box Trp; B657_miscRNA6 1220533000869 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1220533000870 dodecamer interface 1 [polypeptide binding]; other site 1220533000871 dodecamer interface 2 [polypeptide binding]; other site 1220533000872 trimer interface [polypeptide binding]; other site 1220533000873 TRAP binding interface [polypeptide binding]; other site 1220533000874 Zn binding site [ion binding]; other site 1220533000875 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1220533000876 EamA-like transporter family; Region: EamA; pfam00892 1220533000877 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533000878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533000879 active site 1220533000880 phosphorylation site [posttranslational modification] 1220533000881 intermolecular recognition site; other site 1220533000882 dimerization interface [polypeptide binding]; other site 1220533000883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533000884 DNA binding site [nucleotide binding] 1220533000885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533000886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533000887 dimer interface [polypeptide binding]; other site 1220533000888 phosphorylation site [posttranslational modification] 1220533000889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533000890 ATP binding site [chemical binding]; other site 1220533000891 Mg2+ binding site [ion binding]; other site 1220533000892 G-X-G motif; other site 1220533000893 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1220533000894 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1220533000895 Walker A/P-loop; other site 1220533000896 ATP binding site [chemical binding]; other site 1220533000897 Q-loop/lid; other site 1220533000898 ABC transporter signature motif; other site 1220533000899 Walker B; other site 1220533000900 D-loop; other site 1220533000901 H-loop/switch region; other site 1220533000902 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1220533000903 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1220533000904 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1220533000905 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1220533000906 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1220533000907 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1220533000908 metal ion-dependent adhesion site (MIDAS); other site 1220533000909 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1220533000910 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1220533000911 putative active site [active] 1220533000912 putative metal binding site [ion binding]; other site 1220533000913 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1220533000914 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1220533000915 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1220533000916 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1220533000917 putative substrate binding pocket [chemical binding]; other site 1220533000918 AC domain interface; other site 1220533000919 catalytic triad [active] 1220533000920 AB domain interface; other site 1220533000921 interchain disulfide; other site 1220533000922 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1220533000923 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1220533000924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1220533000925 catalytic residue [active] 1220533000926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533000927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533000928 putative substrate translocation pore; other site 1220533000929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533000930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533000931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533000932 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1220533000933 active site 1220533000934 homotetramer interface [polypeptide binding]; other site 1220533000935 homodimer interface [polypeptide binding]; other site 1220533000936 Lipase (class 2); Region: Lipase_2; pfam01674 1220533000937 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1220533000938 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1220533000939 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1220533000940 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1220533000941 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1220533000942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533000943 ATP binding site [chemical binding]; other site 1220533000944 Mg2+ binding site [ion binding]; other site 1220533000945 G-X-G motif; other site 1220533000946 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1220533000947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533000948 active site 1220533000949 phosphorylation site [posttranslational modification] 1220533000950 intermolecular recognition site; other site 1220533000951 dimerization interface [polypeptide binding]; other site 1220533000952 LytTr DNA-binding domain; Region: LytTR; pfam04397 1220533000953 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1220533000954 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 1220533000955 Walker A/P-loop; other site 1220533000956 ATP binding site [chemical binding]; other site 1220533000957 Q-loop/lid; other site 1220533000958 ABC transporter signature motif; other site 1220533000959 Walker B; other site 1220533000960 D-loop; other site 1220533000961 H-loop/switch region; other site 1220533000962 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1220533000963 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1220533000964 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1220533000965 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1220533000966 active site 1220533000967 catalytic tetrad [active] 1220533000968 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1220533000969 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1220533000970 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1220533000971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533000972 binding surface 1220533000973 TPR motif; other site 1220533000974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533000975 TPR motif; other site 1220533000976 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533000977 binding surface 1220533000978 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1220533000979 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1220533000980 NAD binding site [chemical binding]; other site 1220533000981 homodimer interface [polypeptide binding]; other site 1220533000982 active site 1220533000983 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1220533000984 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1220533000985 Ca binding site [ion binding]; other site 1220533000986 active site 1220533000987 catalytic site [active] 1220533000988 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1220533000989 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1220533000990 metal binding site [ion binding]; metal-binding site 1220533000991 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1220533000992 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1220533000993 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1220533000994 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533000995 ABC-ATPase subunit interface; other site 1220533000996 dimer interface [polypeptide binding]; other site 1220533000997 putative PBP binding regions; other site 1220533000998 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1220533000999 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1220533001000 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1220533001001 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1220533001002 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1220533001003 putative metal binding site [ion binding]; other site 1220533001004 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1220533001005 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1220533001006 putative metal binding site [ion binding]; other site 1220533001007 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1220533001008 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1220533001009 putative metal binding site [ion binding]; other site 1220533001010 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1220533001011 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1220533001012 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1220533001013 benzoate transport; Region: 2A0115; TIGR00895 1220533001014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001015 putative substrate translocation pore; other site 1220533001016 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1220533001017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001018 putative substrate translocation pore; other site 1220533001019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533001020 dimerization interface [polypeptide binding]; other site 1220533001021 putative DNA binding site [nucleotide binding]; other site 1220533001022 putative Zn2+ binding site [ion binding]; other site 1220533001023 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1220533001024 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1220533001025 Walker A/P-loop; other site 1220533001026 ATP binding site [chemical binding]; other site 1220533001027 Q-loop/lid; other site 1220533001028 ABC transporter signature motif; other site 1220533001029 Walker B; other site 1220533001030 D-loop; other site 1220533001031 H-loop/switch region; other site 1220533001032 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1220533001033 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1220533001034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533001035 dimer interface [polypeptide binding]; other site 1220533001036 conserved gate region; other site 1220533001037 putative PBP binding loops; other site 1220533001038 ABC-ATPase subunit interface; other site 1220533001039 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1220533001040 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1220533001041 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1220533001042 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1220533001043 amidohydrolase; Region: amidohydrolases; TIGR01891 1220533001044 metal binding site [ion binding]; metal-binding site 1220533001045 putative dimer interface [polypeptide binding]; other site 1220533001046 Predicted membrane protein [Function unknown]; Region: COG1288 1220533001047 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1220533001048 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1220533001049 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1220533001050 active site 1220533001051 Ca binding site [ion binding]; other site 1220533001052 catalytic site [active] 1220533001053 Aamy_C domain; Region: Aamy_C; smart00632 1220533001054 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1220533001055 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1220533001056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1220533001057 NAD binding site [chemical binding]; other site 1220533001058 dimer interface [polypeptide binding]; other site 1220533001059 substrate binding site [chemical binding]; other site 1220533001060 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1220533001061 L-lactate permease; Region: Lactate_perm; pfam02652 1220533001062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533001064 putative substrate translocation pore; other site 1220533001065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001066 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533001067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533001068 putative DNA binding site [nucleotide binding]; other site 1220533001069 putative Zn2+ binding site [ion binding]; other site 1220533001070 LysE type translocator; Region: LysE; pfam01810 1220533001071 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1220533001072 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1220533001073 Spore germination protein; Region: Spore_permease; cl17796 1220533001074 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1220533001075 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1220533001076 NAD+ synthetase; Region: nadE; TIGR00552 1220533001077 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1220533001078 homodimer interface [polypeptide binding]; other site 1220533001079 NAD binding pocket [chemical binding]; other site 1220533001080 ATP binding pocket [chemical binding]; other site 1220533001081 Mg binding site [ion binding]; other site 1220533001082 active-site loop [active] 1220533001083 AAA domain; Region: AAA_17; cl17253 1220533001084 AAA domain; Region: AAA_18; pfam13238 1220533001085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533001086 S-adenosylmethionine binding site [chemical binding]; other site 1220533001087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533001088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533001089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533001090 dimerization interface [polypeptide binding]; other site 1220533001091 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1220533001092 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1220533001093 Proline dehydrogenase; Region: Pro_dh; pfam01619 1220533001094 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1220533001095 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1220533001096 Glutamate binding site [chemical binding]; other site 1220533001097 homodimer interface [polypeptide binding]; other site 1220533001098 NAD binding site [chemical binding]; other site 1220533001099 catalytic residues [active] 1220533001100 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1220533001101 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1220533001102 Na binding site [ion binding]; other site 1220533001103 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1220533001104 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1220533001105 Predicted membrane protein [Function unknown]; Region: COG3689 1220533001106 Predicted permeases [General function prediction only]; Region: COG0701 1220533001107 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533001108 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1220533001109 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1220533001110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533001111 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1220533001112 active site 1220533001113 SAM binding site [chemical binding]; other site 1220533001114 homodimer interface [polypeptide binding]; other site 1220533001115 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1220533001116 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1220533001117 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1220533001118 [2Fe-2S] cluster binding site [ion binding]; other site 1220533001119 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1220533001120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533001121 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1220533001122 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1220533001123 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1220533001124 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1220533001125 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1220533001126 [4Fe-4S] binding site [ion binding]; other site 1220533001127 molybdopterin cofactor binding site; other site 1220533001128 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1220533001129 molybdopterin cofactor binding site; other site 1220533001130 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1220533001131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533001132 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1220533001133 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1220533001134 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1220533001135 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1220533001136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001137 putative substrate translocation pore; other site 1220533001138 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1220533001139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1220533001140 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1220533001141 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1220533001142 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1220533001143 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1220533001144 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1220533001145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533001146 dimer interface [polypeptide binding]; other site 1220533001147 conserved gate region; other site 1220533001148 putative PBP binding loops; other site 1220533001149 ABC-ATPase subunit interface; other site 1220533001150 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1220533001151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1220533001152 substrate binding pocket [chemical binding]; other site 1220533001153 membrane-bound complex binding site; other site 1220533001154 hinge residues; other site 1220533001155 RDD family; Region: RDD; pfam06271 1220533001156 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1220533001157 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1220533001158 beta-galactosidase; Region: BGL; TIGR03356 1220533001159 Competence protein J (ComJ); Region: ComJ; pfam11033 1220533001160 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1220533001161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533001162 dimerization interface [polypeptide binding]; other site 1220533001163 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533001164 dimer interface [polypeptide binding]; other site 1220533001165 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1220533001166 putative CheW interface [polypeptide binding]; other site 1220533001167 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1220533001168 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1220533001169 tetramer interface [polypeptide binding]; other site 1220533001170 active site 1220533001171 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1220533001172 active site 1220533001173 dimer interface [polypeptide binding]; other site 1220533001174 magnesium binding site [ion binding]; other site 1220533001175 Predicted transcriptional regulators [Transcription]; Region: COG1733 1220533001176 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1220533001177 Condensation domain; Region: Condensation; pfam00668 1220533001178 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533001179 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533001180 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533001181 acyl-activating enzyme (AAE) consensus motif; other site 1220533001182 AMP binding site [chemical binding]; other site 1220533001183 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533001184 Condensation domain; Region: Condensation; pfam00668 1220533001185 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533001186 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533001187 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1220533001188 acyl-activating enzyme (AAE) consensus motif; other site 1220533001189 AMP binding site [chemical binding]; other site 1220533001190 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533001191 Condensation domain; Region: Condensation; pfam00668 1220533001192 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533001193 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533001194 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533001195 acyl-activating enzyme (AAE) consensus motif; other site 1220533001196 AMP binding site [chemical binding]; other site 1220533001197 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533001198 Condensation domain; Region: Condensation; pfam00668 1220533001199 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533001200 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1220533001201 Condensation domain; Region: Condensation; pfam00668 1220533001202 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533001203 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1220533001204 acyl-activating enzyme (AAE) consensus motif; other site 1220533001205 AMP binding site [chemical binding]; other site 1220533001206 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533001207 Condensation domain; Region: Condensation; pfam00668 1220533001208 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533001209 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533001210 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533001211 acyl-activating enzyme (AAE) consensus motif; other site 1220533001212 AMP binding site [chemical binding]; other site 1220533001213 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533001214 Condensation domain; Region: Condensation; pfam00668 1220533001215 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533001216 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533001217 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533001218 acyl-activating enzyme (AAE) consensus motif; other site 1220533001219 AMP binding site [chemical binding]; other site 1220533001220 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533001221 Condensation domain; Region: Condensation; pfam00668 1220533001222 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1220533001223 Condensation domain; Region: Condensation; pfam00668 1220533001224 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533001225 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1220533001226 acyl-activating enzyme (AAE) consensus motif; other site 1220533001227 AMP binding site [chemical binding]; other site 1220533001228 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533001229 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1220533001230 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1220533001231 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1220533001232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533001234 putative substrate translocation pore; other site 1220533001235 YcxB-like protein; Region: YcxB; pfam14317 1220533001236 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1220533001237 EamA-like transporter family; Region: EamA; pfam00892 1220533001238 EamA-like transporter family; Region: EamA; pfam00892 1220533001239 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1220533001240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533001241 DNA-binding site [nucleotide binding]; DNA binding site 1220533001242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533001243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533001244 homodimer interface [polypeptide binding]; other site 1220533001245 catalytic residue [active] 1220533001246 Predicted membrane protein [Function unknown]; Region: COG2364 1220533001247 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533001248 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1220533001249 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1220533001250 Walker A/P-loop; other site 1220533001251 ATP binding site [chemical binding]; other site 1220533001252 Q-loop/lid; other site 1220533001253 ABC transporter signature motif; other site 1220533001254 Walker B; other site 1220533001255 D-loop; other site 1220533001256 H-loop/switch region; other site 1220533001257 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1220533001258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533001259 dimer interface [polypeptide binding]; other site 1220533001260 conserved gate region; other site 1220533001261 putative PBP binding loops; other site 1220533001262 ABC-ATPase subunit interface; other site 1220533001263 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1220533001264 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1220533001265 substrate binding pocket [chemical binding]; other site 1220533001266 membrane-bound complex binding site; other site 1220533001267 hinge residues; other site 1220533001268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533001269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533001270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533001271 dimerization interface [polypeptide binding]; other site 1220533001272 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 1220533001273 Flavoprotein; Region: Flavoprotein; pfam02441 1220533001274 UbiD family decarboxylase; Region: TIGR00148 1220533001275 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1220533001276 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533001277 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1220533001278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001279 putative substrate translocation pore; other site 1220533001280 POT family; Region: PTR2; pfam00854 1220533001281 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1220533001282 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1220533001283 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1220533001284 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1220533001285 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1220533001286 Spore germination protein; Region: Spore_permease; pfam03845 1220533001287 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1220533001288 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1220533001289 Walker A/P-loop; other site 1220533001290 ATP binding site [chemical binding]; other site 1220533001291 Q-loop/lid; other site 1220533001292 ABC transporter signature motif; other site 1220533001293 Walker B; other site 1220533001294 D-loop; other site 1220533001295 H-loop/switch region; other site 1220533001296 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1220533001297 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1220533001298 FtsX-like permease family; Region: FtsX; pfam02687 1220533001299 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533001300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533001301 active site 1220533001302 phosphorylation site [posttranslational modification] 1220533001303 intermolecular recognition site; other site 1220533001304 dimerization interface [polypeptide binding]; other site 1220533001305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533001306 DNA binding site [nucleotide binding] 1220533001307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533001308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533001309 dimerization interface [polypeptide binding]; other site 1220533001310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533001311 dimer interface [polypeptide binding]; other site 1220533001312 phosphorylation site [posttranslational modification] 1220533001313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533001314 ATP binding site [chemical binding]; other site 1220533001315 Mg2+ binding site [ion binding]; other site 1220533001316 G-X-G motif; other site 1220533001317 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533001318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533001319 TPR motif; other site 1220533001320 binding surface 1220533001321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533001322 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1220533001323 aspartate kinase; Reviewed; Region: PRK09034 1220533001324 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1220533001325 putative catalytic residues [active] 1220533001326 putative nucleotide binding site [chemical binding]; other site 1220533001327 putative aspartate binding site [chemical binding]; other site 1220533001328 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1220533001329 allosteric regulatory residue; other site 1220533001330 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1220533001331 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1220533001332 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533001333 ABC-ATPase subunit interface; other site 1220533001334 dimer interface [polypeptide binding]; other site 1220533001335 putative PBP binding regions; other site 1220533001336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533001337 ABC-ATPase subunit interface; other site 1220533001338 dimer interface [polypeptide binding]; other site 1220533001339 putative PBP binding regions; other site 1220533001340 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1220533001341 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1220533001342 Walker A/P-loop; other site 1220533001343 ATP binding site [chemical binding]; other site 1220533001344 Q-loop/lid; other site 1220533001345 ABC transporter signature motif; other site 1220533001346 Walker B; other site 1220533001347 D-loop; other site 1220533001348 H-loop/switch region; other site 1220533001349 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1220533001350 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1220533001351 putative ligand binding residues [chemical binding]; other site 1220533001352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001353 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533001354 putative substrate translocation pore; other site 1220533001355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533001357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533001358 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1220533001359 dimer interface [polypeptide binding]; other site 1220533001360 FMN binding site [chemical binding]; other site 1220533001361 NADPH bind site [chemical binding]; other site 1220533001362 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1220533001363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533001364 dimerization interface [polypeptide binding]; other site 1220533001365 putative DNA binding site [nucleotide binding]; other site 1220533001366 putative Zn2+ binding site [ion binding]; other site 1220533001367 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1220533001368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533001369 DNA-binding site [nucleotide binding]; DNA binding site 1220533001370 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533001371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533001372 homodimer interface [polypeptide binding]; other site 1220533001373 catalytic residue [active] 1220533001374 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1220533001375 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1220533001376 inhibitor-cofactor binding pocket; inhibition site 1220533001377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533001378 catalytic residue [active] 1220533001379 succinic semialdehyde dehydrogenase; Region: PLN02278 1220533001380 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1220533001381 tetramerization interface [polypeptide binding]; other site 1220533001382 NAD(P) binding site [chemical binding]; other site 1220533001383 catalytic residues [active] 1220533001384 Sugar transport protein; Region: Sugar_transport; pfam06800 1220533001385 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1220533001386 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1220533001387 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1220533001388 NAD binding site [chemical binding]; other site 1220533001389 homodimer interface [polypeptide binding]; other site 1220533001390 active site 1220533001391 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1220533001392 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1220533001393 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1220533001394 YtkA-like; Region: YtkA; pfam13115 1220533001395 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1220533001396 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1220533001397 NosL; Region: NosL; cl01769 1220533001398 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1220533001399 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1220533001400 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1220533001401 active site 1220533001402 P-loop; other site 1220533001403 phosphorylation site [posttranslational modification] 1220533001404 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1220533001405 active site 1220533001406 phosphorylation site [posttranslational modification] 1220533001407 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1220533001408 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1220533001409 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1220533001410 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1220533001411 tartrate dehydrogenase; Provisional; Region: PRK08194 1220533001412 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1220533001413 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1220533001414 Catalytic site [active] 1220533001415 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1220533001416 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1220533001417 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1220533001418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533001419 active site 1220533001420 motif I; other site 1220533001421 motif II; other site 1220533001422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533001423 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1220533001424 putative active site [active] 1220533001425 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1220533001426 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1220533001427 hypothetical protein; Provisional; Region: PRK05463 1220533001428 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1220533001429 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1220533001430 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1220533001431 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1220533001432 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1220533001433 Bacterial transcriptional regulator; Region: IclR; pfam01614 1220533001434 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 1220533001435 active site 1220533001436 catalytic triad [active] 1220533001437 oxyanion hole [active] 1220533001438 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1220533001439 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1220533001440 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1220533001441 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1220533001442 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1220533001443 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1220533001444 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1220533001445 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1220533001446 active site 1220533001447 catalytic tetrad [active] 1220533001448 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1220533001449 HTH domain; Region: HTH_11; pfam08279 1220533001450 PRD domain; Region: PRD; pfam00874 1220533001451 PRD domain; Region: PRD; pfam00874 1220533001452 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1220533001453 active site 1220533001454 P-loop; other site 1220533001455 phosphorylation site [posttranslational modification] 1220533001456 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1220533001457 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1220533001458 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1220533001459 acyl-activating enzyme (AAE) consensus motif; other site 1220533001460 putative AMP binding site [chemical binding]; other site 1220533001461 putative active site [active] 1220533001462 putative CoA binding site [chemical binding]; other site 1220533001463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533001464 S-adenosylmethionine binding site [chemical binding]; other site 1220533001465 short chain dehydrogenase; Provisional; Region: PRK06701 1220533001466 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1220533001467 NAD binding site [chemical binding]; other site 1220533001468 metal binding site [ion binding]; metal-binding site 1220533001469 active site 1220533001470 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1220533001471 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1220533001472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1220533001473 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1220533001474 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1220533001475 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1220533001476 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1220533001477 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1220533001478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533001479 putative DNA binding site [nucleotide binding]; other site 1220533001480 putative Zn2+ binding site [ion binding]; other site 1220533001481 AsnC family; Region: AsnC_trans_reg; pfam01037 1220533001482 DNA topoisomerase III; Provisional; Region: PRK07726 1220533001483 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1220533001484 active site 1220533001485 putative interdomain interaction site [polypeptide binding]; other site 1220533001486 putative metal-binding site [ion binding]; other site 1220533001487 putative nucleotide binding site [chemical binding]; other site 1220533001488 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1220533001489 domain I; other site 1220533001490 DNA binding groove [nucleotide binding] 1220533001491 phosphate binding site [ion binding]; other site 1220533001492 domain II; other site 1220533001493 domain III; other site 1220533001494 nucleotide binding site [chemical binding]; other site 1220533001495 catalytic site [active] 1220533001496 domain IV; other site 1220533001497 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1220533001498 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1220533001499 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1220533001500 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1220533001501 metal binding site [ion binding]; metal-binding site 1220533001502 active site 1220533001503 I-site; other site 1220533001504 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1220533001505 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1220533001506 NodB motif; other site 1220533001507 putative active site [active] 1220533001508 putative catalytic site [active] 1220533001509 putative Zn binding site [ion binding]; other site 1220533001510 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1220533001511 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1220533001512 DXD motif; other site 1220533001513 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1220533001514 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1220533001515 ydaO-yuaA; B657_miscRNA7 1220533001516 Amino acid permease; Region: AA_permease_2; pfam13520 1220533001517 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1220533001518 nudix motif; other site 1220533001519 pyruvate oxidase; Provisional; Region: PRK08611 1220533001520 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1220533001521 PYR/PP interface [polypeptide binding]; other site 1220533001522 tetramer interface [polypeptide binding]; other site 1220533001523 dimer interface [polypeptide binding]; other site 1220533001524 TPP binding site [chemical binding]; other site 1220533001525 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1220533001526 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1220533001527 TPP-binding site [chemical binding]; other site 1220533001528 manganese transport protein MntH; Reviewed; Region: PRK00701 1220533001529 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1220533001530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1220533001531 EcsC protein family; Region: EcsC; pfam12787 1220533001532 General stress protein [General function prediction only]; Region: GsiB; COG3729 1220533001533 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1220533001534 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1220533001535 dimanganese center [ion binding]; other site 1220533001536 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1220533001537 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1220533001538 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1220533001539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533001540 putative active site [active] 1220533001541 heme pocket [chemical binding]; other site 1220533001542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533001543 ATP binding site [chemical binding]; other site 1220533001544 Mg2+ binding site [ion binding]; other site 1220533001545 G-X-G motif; other site 1220533001546 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1220533001547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533001548 active site 1220533001549 phosphorylation site [posttranslational modification] 1220533001550 intermolecular recognition site; other site 1220533001551 dimerization interface [polypeptide binding]; other site 1220533001552 HTH domain; Region: HTH_11; cl17392 1220533001553 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1220533001554 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1220533001555 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1220533001556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1220533001557 Walker A/P-loop; other site 1220533001558 ATP binding site [chemical binding]; other site 1220533001559 Q-loop/lid; other site 1220533001560 ABC transporter signature motif; other site 1220533001561 Walker B; other site 1220533001562 D-loop; other site 1220533001563 H-loop/switch region; other site 1220533001564 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1220533001565 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1220533001566 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1220533001567 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1220533001568 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1220533001569 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1220533001570 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1220533001571 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1220533001572 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1220533001573 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1220533001574 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1220533001575 catalytic residues [active] 1220533001576 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1220533001577 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1220533001578 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1220533001579 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1220533001580 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1220533001581 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1220533001582 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1220533001583 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1220533001584 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1220533001585 ATP binding site [chemical binding]; other site 1220533001586 Mg++ binding site [ion binding]; other site 1220533001587 motif III; other site 1220533001588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533001589 nucleotide binding region [chemical binding]; other site 1220533001590 ATP-binding site [chemical binding]; other site 1220533001591 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1220533001592 Predicted membrane protein [Function unknown]; Region: COG3428 1220533001593 Bacterial PH domain; Region: DUF304; pfam03703 1220533001594 Bacterial PH domain; Region: DUF304; pfam03703 1220533001595 Bacterial PH domain; Region: DUF304; pfam03703 1220533001596 Rhomboid family; Region: Rhomboid; pfam01694 1220533001597 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 1220533001598 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1220533001599 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1220533001600 ribbon-helix-helix domain containing protein; Region: PHA00617 1220533001601 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1220533001602 Rsbr N terminal; Region: Rsbr_N; pfam08678 1220533001603 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1220533001604 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1220533001605 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1220533001606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533001607 ATP binding site [chemical binding]; other site 1220533001608 Mg2+ binding site [ion binding]; other site 1220533001609 G-X-G motif; other site 1220533001610 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1220533001611 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1220533001612 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1220533001613 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1220533001614 anti sigma factor interaction site; other site 1220533001615 regulatory phosphorylation site [posttranslational modification]; other site 1220533001616 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1220533001617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533001618 ATP binding site [chemical binding]; other site 1220533001619 Mg2+ binding site [ion binding]; other site 1220533001620 G-X-G motif; other site 1220533001621 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1220533001622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533001623 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1220533001624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533001625 DNA binding residues [nucleotide binding] 1220533001626 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1220533001627 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1220533001628 hypothetical protein; Provisional; Region: PRK02268 1220533001629 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533001630 MarR family; Region: MarR; pfam01047 1220533001631 MarR family; Region: MarR_2; cl17246 1220533001632 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1220533001633 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1220533001634 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1220533001635 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1220533001636 RNA binding site [nucleotide binding]; other site 1220533001637 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1220533001638 hypothetical protein; Provisional; Region: PRK04351 1220533001639 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1220533001640 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1220533001641 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1220533001642 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1220533001643 AsnC family; Region: AsnC_trans_reg; pfam01037 1220533001644 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1220533001645 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1220533001646 putative DNA binding site [nucleotide binding]; other site 1220533001647 putative Zn2+ binding site [ion binding]; other site 1220533001648 AsnC family; Region: AsnC_trans_reg; pfam01037 1220533001649 Isochorismatase family; Region: Isochorismatase; pfam00857 1220533001650 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1220533001651 catalytic triad [active] 1220533001652 conserved cis-peptide bond; other site 1220533001653 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1220533001654 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1220533001655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001656 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533001657 putative substrate translocation pore; other site 1220533001658 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1220533001659 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1220533001660 conserved cys residue [active] 1220533001661 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1220533001662 DNA-binding site [nucleotide binding]; DNA binding site 1220533001663 RNA-binding motif; other site 1220533001664 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1220533001665 EamA-like transporter family; Region: EamA; pfam00892 1220533001666 Cupin domain; Region: Cupin_2; pfam07883 1220533001667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533001668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533001669 EamA-like transporter family; Region: EamA; pfam00892 1220533001670 EamA-like transporter family; Region: EamA; pfam00892 1220533001671 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533001672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533001673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1220533001674 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1220533001675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533001676 DNA-binding site [nucleotide binding]; DNA binding site 1220533001677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533001678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533001679 homodimer interface [polypeptide binding]; other site 1220533001680 catalytic residue [active] 1220533001681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001682 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533001683 putative substrate translocation pore; other site 1220533001684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1220533001685 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1220533001686 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1220533001687 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1220533001688 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1220533001689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533001690 DNA-binding site [nucleotide binding]; DNA binding site 1220533001691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533001692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533001693 homodimer interface [polypeptide binding]; other site 1220533001694 catalytic residue [active] 1220533001695 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1220533001696 putative active site [active] 1220533001697 putative catalytic site [active] 1220533001698 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1220533001699 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1220533001700 Predicted transcriptional regulators [Transcription]; Region: COG1733 1220533001701 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1220533001702 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1220533001703 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533001704 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533001705 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1220533001706 Predicted transcriptional regulators [Transcription]; Region: COG1733 1220533001707 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1220533001708 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1220533001709 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1220533001710 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1220533001711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001712 putative substrate translocation pore; other site 1220533001713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533001714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533001715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533001716 dimerization interface [polypeptide binding]; other site 1220533001717 putative DNA binding site [nucleotide binding]; other site 1220533001718 putative Zn2+ binding site [ion binding]; other site 1220533001719 arsenical pump membrane protein; Provisional; Region: PRK15445 1220533001720 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1220533001721 transmembrane helices; other site 1220533001722 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1220533001723 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1220533001724 EamA-like transporter family; Region: EamA; pfam00892 1220533001725 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1220533001726 EamA-like transporter family; Region: EamA; pfam00892 1220533001727 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1220533001728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533001729 DNA-binding site [nucleotide binding]; DNA binding site 1220533001730 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533001731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533001732 homodimer interface [polypeptide binding]; other site 1220533001733 catalytic residue [active] 1220533001734 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1220533001735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533001736 putative DNA binding site [nucleotide binding]; other site 1220533001737 putative Zn2+ binding site [ion binding]; other site 1220533001738 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1220533001739 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1220533001740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1220533001741 Histidine kinase; Region: HisKA_3; pfam07730 1220533001742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533001743 ATP binding site [chemical binding]; other site 1220533001744 Mg2+ binding site [ion binding]; other site 1220533001745 G-X-G motif; other site 1220533001746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533001747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533001748 active site 1220533001749 phosphorylation site [posttranslational modification] 1220533001750 intermolecular recognition site; other site 1220533001751 dimerization interface [polypeptide binding]; other site 1220533001752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533001753 DNA binding residues [nucleotide binding] 1220533001754 dimerization interface [polypeptide binding]; other site 1220533001755 MMPL family; Region: MMPL; pfam03176 1220533001756 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1220533001757 MMPL family; Region: MMPL; pfam03176 1220533001758 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533001759 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1220533001760 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1220533001761 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1220533001762 DNA binding residues [nucleotide binding] 1220533001763 drug binding residues [chemical binding]; other site 1220533001764 dimer interface [polypeptide binding]; other site 1220533001765 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1220533001766 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1220533001767 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1220533001768 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1220533001769 dimer interface [polypeptide binding]; other site 1220533001770 FMN binding site [chemical binding]; other site 1220533001771 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1220533001772 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533001773 Zn binding site [ion binding]; other site 1220533001774 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1220533001775 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533001776 Zn binding site [ion binding]; other site 1220533001777 Predicted membrane protein [Function unknown]; Region: COG2259 1220533001778 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1220533001779 catalytic residues [active] 1220533001780 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1220533001781 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1220533001782 Predicted membrane protein [Function unknown]; Region: COG2323 1220533001783 Predicted membrane protein [Function unknown]; Region: COG2323 1220533001784 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1220533001785 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1220533001786 putative dimer interface [polypeptide binding]; other site 1220533001787 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1220533001788 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1220533001789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533001790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533001791 DoxX-like family; Region: DoxX_2; pfam13564 1220533001792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1220533001793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533001794 Coenzyme A binding pocket [chemical binding]; other site 1220533001795 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1220533001796 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533001797 ABC transporter; Region: ABC_tran_2; pfam12848 1220533001798 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533001799 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1220533001800 DinB family; Region: DinB; pfam05163 1220533001801 DinB superfamily; Region: DinB_2; pfam12867 1220533001802 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533001803 MarR family; Region: MarR; pfam01047 1220533001804 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1220533001805 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1220533001806 dimer interface [polypeptide binding]; other site 1220533001807 FMN binding site [chemical binding]; other site 1220533001808 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533001809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533001810 putative DNA binding site [nucleotide binding]; other site 1220533001811 putative Zn2+ binding site [ion binding]; other site 1220533001812 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1220533001813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001814 putative substrate translocation pore; other site 1220533001815 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1220533001816 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1220533001817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533001818 DNA-binding site [nucleotide binding]; DNA binding site 1220533001819 FCD domain; Region: FCD; pfam07729 1220533001820 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1220533001821 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533001822 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533001823 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1220533001824 active site 1220533001825 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1220533001826 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1220533001827 homodimer interface [polypeptide binding]; other site 1220533001828 active site 1220533001829 TDP-binding site; other site 1220533001830 acceptor substrate-binding pocket; other site 1220533001831 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1220533001832 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1220533001833 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1220533001834 dimer interface [polypeptide binding]; other site 1220533001835 active site 1220533001836 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1220533001837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533001838 Coenzyme A binding pocket [chemical binding]; other site 1220533001839 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1220533001840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1220533001841 Zn2+ binding site [ion binding]; other site 1220533001842 Mg2+ binding site [ion binding]; other site 1220533001843 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1220533001844 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1220533001845 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1220533001846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001847 putative substrate translocation pore; other site 1220533001848 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1220533001849 active site 1220533001850 P-loop; other site 1220533001851 phosphorylation site [posttranslational modification] 1220533001852 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1220533001853 active site 1220533001854 methionine cluster; other site 1220533001855 phosphorylation site [posttranslational modification] 1220533001856 metal binding site [ion binding]; metal-binding site 1220533001857 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1220533001858 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1220533001859 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1220533001860 beta-galactosidase; Region: BGL; TIGR03356 1220533001861 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1220533001862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533001863 DNA-binding site [nucleotide binding]; DNA binding site 1220533001864 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1220533001865 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1220533001866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1220533001867 nucleotide binding site [chemical binding]; other site 1220533001868 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1220533001869 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1220533001870 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1220533001871 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1220533001872 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1220533001873 ATP binding site [chemical binding]; other site 1220533001874 dimerization interface [polypeptide binding]; other site 1220533001875 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1220533001876 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1220533001877 Glycoprotease family; Region: Peptidase_M22; pfam00814 1220533001878 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1220533001879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533001880 Coenzyme A binding pocket [chemical binding]; other site 1220533001881 UGMP family protein; Validated; Region: PRK09604 1220533001882 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1220533001883 nucleotide binding site [chemical binding]; other site 1220533001884 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1220533001885 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533001886 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533001887 ABC transporter; Region: ABC_tran_2; pfam12848 1220533001888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533001889 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1220533001890 trimer interface [polypeptide binding]; other site 1220533001891 dimer interface [polypeptide binding]; other site 1220533001892 putative active site [active] 1220533001893 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1220533001894 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1220533001895 CoA binding domain; Region: CoA_binding; pfam02629 1220533001896 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1220533001897 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 1220533001898 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1220533001899 CAAX protease self-immunity; Region: Abi; pfam02517 1220533001900 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1220533001901 oligomerisation interface [polypeptide binding]; other site 1220533001902 mobile loop; other site 1220533001903 roof hairpin; other site 1220533001904 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1220533001905 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1220533001906 ring oligomerisation interface [polypeptide binding]; other site 1220533001907 ATP/Mg binding site [chemical binding]; other site 1220533001908 stacking interactions; other site 1220533001909 hinge regions; other site 1220533001910 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1220533001911 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1220533001912 cofactor binding site; other site 1220533001913 DNA binding site [nucleotide binding] 1220533001914 substrate interaction site [chemical binding]; other site 1220533001915 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1220533001916 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1220533001917 cofactor binding site; other site 1220533001918 DNA binding site [nucleotide binding] 1220533001919 substrate interaction site [chemical binding]; other site 1220533001920 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 1220533001921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1220533001922 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 1220533001923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1220533001924 Walker A motif; other site 1220533001925 ATP binding site [chemical binding]; other site 1220533001926 Walker B motif; other site 1220533001927 TPR repeat; Region: TPR_11; pfam13414 1220533001928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533001929 TPR motif; other site 1220533001930 TPR repeat; Region: TPR_11; pfam13414 1220533001931 binding surface 1220533001932 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1220533001933 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1220533001934 inhibitor binding site; inhibition site 1220533001935 catalytic Zn binding site [ion binding]; other site 1220533001936 structural Zn binding site [ion binding]; other site 1220533001937 NADP binding site [chemical binding]; other site 1220533001938 tetramer interface [polypeptide binding]; other site 1220533001939 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1220533001940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001941 putative substrate translocation pore; other site 1220533001942 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1220533001943 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1220533001944 putative substrate binding site [chemical binding]; other site 1220533001945 putative ATP binding site [chemical binding]; other site 1220533001946 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1220533001947 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1220533001948 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 1220533001949 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1220533001950 Repair protein; Region: Repair_PSII; pfam04536 1220533001951 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1220533001952 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1220533001953 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1220533001954 Double zinc ribbon; Region: DZR; pfam12773 1220533001955 Ion channel; Region: Ion_trans_2; pfam07885 1220533001956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001957 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1220533001958 putative substrate translocation pore; other site 1220533001959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533001960 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1220533001961 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1220533001962 putative NAD(P) binding site [chemical binding]; other site 1220533001963 catalytic Zn binding site [ion binding]; other site 1220533001964 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1220533001965 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1220533001966 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533001967 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1220533001968 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1220533001969 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1220533001970 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1220533001971 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1220533001972 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1220533001973 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1220533001974 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1220533001975 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1220533001976 MoxR-like ATPases [General function prediction only]; Region: COG0714 1220533001977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533001978 Walker A motif; other site 1220533001979 ATP binding site [chemical binding]; other site 1220533001980 Walker B motif; other site 1220533001981 arginine finger; other site 1220533001982 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1220533001983 Protein of unknown function DUF58; Region: DUF58; pfam01882 1220533001984 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1220533001985 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1220533001986 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1220533001987 GMP synthase; Reviewed; Region: guaA; PRK00074 1220533001988 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1220533001989 AMP/PPi binding site [chemical binding]; other site 1220533001990 candidate oxyanion hole; other site 1220533001991 catalytic triad [active] 1220533001992 potential glutamine specificity residues [chemical binding]; other site 1220533001993 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1220533001994 ATP Binding subdomain [chemical binding]; other site 1220533001995 Ligand Binding sites [chemical binding]; other site 1220533001996 Dimerization subdomain; other site 1220533001997 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1220533001998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1220533001999 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1220533002000 NETI protein; Region: NETI; pfam14044 1220533002001 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1220533002002 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1220533002003 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1220533002004 NAD binding site [chemical binding]; other site 1220533002005 ATP-grasp domain; Region: ATP-grasp; pfam02222 1220533002006 adenylosuccinate lyase; Provisional; Region: PRK07492 1220533002007 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1220533002008 tetramer interface [polypeptide binding]; other site 1220533002009 active site 1220533002010 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1220533002011 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1220533002012 ATP binding site [chemical binding]; other site 1220533002013 active site 1220533002014 substrate binding site [chemical binding]; other site 1220533002015 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1220533002016 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1220533002017 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1220533002018 putative active site [active] 1220533002019 catalytic triad [active] 1220533002020 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1220533002021 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1220533002022 dimerization interface [polypeptide binding]; other site 1220533002023 ATP binding site [chemical binding]; other site 1220533002024 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1220533002025 dimerization interface [polypeptide binding]; other site 1220533002026 ATP binding site [chemical binding]; other site 1220533002027 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1220533002028 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1220533002029 active site 1220533002030 tetramer interface [polypeptide binding]; other site 1220533002031 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533002032 active site 1220533002033 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1220533002034 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1220533002035 dimerization interface [polypeptide binding]; other site 1220533002036 putative ATP binding site [chemical binding]; other site 1220533002037 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1220533002038 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1220533002039 active site 1220533002040 substrate binding site [chemical binding]; other site 1220533002041 cosubstrate binding site; other site 1220533002042 catalytic site [active] 1220533002043 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1220533002044 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1220533002045 purine monophosphate binding site [chemical binding]; other site 1220533002046 dimer interface [polypeptide binding]; other site 1220533002047 putative catalytic residues [active] 1220533002048 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1220533002049 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1220533002050 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1220533002051 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1220533002052 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1220533002053 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1220533002054 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1220533002055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533002056 putative DNA binding site [nucleotide binding]; other site 1220533002057 putative Zn2+ binding site [ion binding]; other site 1220533002058 AsnC family; Region: AsnC_trans_reg; pfam01037 1220533002059 putative transporter; Provisional; Region: PRK11021 1220533002060 Spore germination protein; Region: Spore_permease; cl17796 1220533002061 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1220533002062 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1220533002063 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1220533002064 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1220533002065 active site 1220533002066 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1220533002067 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1220533002068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1220533002069 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1220533002070 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1220533002071 active site 1220533002072 FMN binding site [chemical binding]; other site 1220533002073 substrate binding site [chemical binding]; other site 1220533002074 3Fe-4S cluster binding site [ion binding]; other site 1220533002075 PcrB family; Region: PcrB; pfam01884 1220533002076 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1220533002077 substrate binding site [chemical binding]; other site 1220533002078 putative active site [active] 1220533002079 dimer interface [polypeptide binding]; other site 1220533002080 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1220533002081 Part of AAA domain; Region: AAA_19; pfam13245 1220533002082 Family description; Region: UvrD_C_2; pfam13538 1220533002083 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1220533002084 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1220533002085 nucleotide binding pocket [chemical binding]; other site 1220533002086 K-X-D-G motif; other site 1220533002087 catalytic site [active] 1220533002088 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1220533002089 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1220533002090 Helix-hairpin-helix motif; Region: HHH; pfam00633 1220533002091 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1220533002092 Dimer interface [polypeptide binding]; other site 1220533002093 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1220533002094 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1220533002095 putative dimer interface [polypeptide binding]; other site 1220533002096 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1220533002097 putative dimer interface [polypeptide binding]; other site 1220533002098 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1220533002099 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1220533002100 active site 1220533002101 ATP binding site [chemical binding]; other site 1220533002102 substrate binding site [chemical binding]; other site 1220533002103 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1220533002104 MgtC family; Region: MgtC; pfam02308 1220533002105 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1220533002106 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1220533002107 Na binding site [ion binding]; other site 1220533002108 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1220533002109 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1220533002110 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1220533002111 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1220533002112 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1220533002113 GatB domain; Region: GatB_Yqey; pfam02637 1220533002114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533002115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533002116 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1220533002117 Protein export membrane protein; Region: SecD_SecF; cl14618 1220533002118 Protein export membrane protein; Region: SecD_SecF; cl14618 1220533002119 putative lipid kinase; Reviewed; Region: PRK13337 1220533002120 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1220533002121 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1220533002122 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1220533002123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533002124 S-adenosylmethionine binding site [chemical binding]; other site 1220533002125 Recombinase; Region: Recombinase; pfam07508 1220533002126 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1220533002127 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1220533002128 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1220533002129 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1220533002130 DNA-binding interface [nucleotide binding]; DNA binding site 1220533002131 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1220533002132 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1220533002133 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1220533002134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533002135 ATP binding site [chemical binding]; other site 1220533002136 putative Mg++ binding site [ion binding]; other site 1220533002137 T5orf172 domain; Region: T5orf172; pfam10544 1220533002138 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1220533002139 Protein of unknown function, DUF600; Region: DUF600; cl04640 1220533002140 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1220533002141 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1220533002142 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533002143 hypothetical protein; Provisional; Region: PRK12378 1220533002144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533002145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533002146 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1220533002147 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1220533002148 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1220533002149 NADP binding site [chemical binding]; other site 1220533002150 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1220533002151 CotJB protein; Region: CotJB; pfam12652 1220533002152 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1220533002153 dimanganese center [ion binding]; other site 1220533002154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533002155 Coenzyme A binding pocket [chemical binding]; other site 1220533002156 YesK-like protein; Region: YesK; pfam14150 1220533002157 Predicted integral membrane protein [Function unknown]; Region: COG5578 1220533002158 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1220533002159 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1220533002160 dimerization interface [polypeptide binding]; other site 1220533002161 Histidine kinase; Region: His_kinase; pfam06580 1220533002162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533002163 ATP binding site [chemical binding]; other site 1220533002164 Mg2+ binding site [ion binding]; other site 1220533002165 G-X-G motif; other site 1220533002166 Response regulator receiver domain; Region: Response_reg; pfam00072 1220533002167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533002168 active site 1220533002169 phosphorylation site [posttranslational modification] 1220533002170 intermolecular recognition site; other site 1220533002171 dimerization interface [polypeptide binding]; other site 1220533002172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533002173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533002174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1220533002175 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1220533002176 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1220533002177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533002178 dimer interface [polypeptide binding]; other site 1220533002179 conserved gate region; other site 1220533002180 putative PBP binding loops; other site 1220533002181 ABC-ATPase subunit interface; other site 1220533002182 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1220533002183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533002184 dimer interface [polypeptide binding]; other site 1220533002185 conserved gate region; other site 1220533002186 putative PBP binding loops; other site 1220533002187 ABC-ATPase subunit interface; other site 1220533002188 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1220533002189 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533002190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533002191 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1220533002192 active site 1220533002193 catalytic triad [active] 1220533002194 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1220533002195 Predicted integral membrane protein [Function unknown]; Region: COG5578 1220533002196 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1220533002197 metal binding site [ion binding]; metal-binding site 1220533002198 active site 1220533002199 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1220533002200 metal binding site [ion binding]; metal-binding site 1220533002201 active site 1220533002202 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1220533002203 active site 1220533002204 catalytic triad [active] 1220533002205 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1220533002206 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1220533002207 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1220533002208 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1220533002209 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1220533002210 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1220533002211 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1220533002212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533002213 dimer interface [polypeptide binding]; other site 1220533002214 putative PBP binding loops; other site 1220533002215 ABC-ATPase subunit interface; other site 1220533002216 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1220533002217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533002218 dimer interface [polypeptide binding]; other site 1220533002219 conserved gate region; other site 1220533002220 putative PBP binding loops; other site 1220533002221 ABC-ATPase subunit interface; other site 1220533002222 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1220533002223 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1220533002224 NAD binding site [chemical binding]; other site 1220533002225 sugar binding site [chemical binding]; other site 1220533002226 divalent metal binding site [ion binding]; other site 1220533002227 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1220533002228 dimer interface [polypeptide binding]; other site 1220533002229 Predicted membrane protein [Function unknown]; Region: COG2323 1220533002230 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1220533002231 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533002232 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1220533002233 Uncharacterized small protein [Function unknown]; Region: COG5583 1220533002234 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1220533002235 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1220533002236 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1220533002237 EamA-like transporter family; Region: EamA; pfam00892 1220533002238 EamA-like transporter family; Region: EamA; pfam00892 1220533002239 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533002240 MarR family; Region: MarR; pfam01047 1220533002241 hypothetical protein; Provisional; Region: PRK06847 1220533002242 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1220533002243 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1220533002244 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1220533002245 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1220533002246 Cytochrome P450; Region: p450; pfam00067 1220533002247 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1220533002248 Flavodoxin; Region: Flavodoxin_1; pfam00258 1220533002249 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1220533002250 FAD binding pocket [chemical binding]; other site 1220533002251 FAD binding motif [chemical binding]; other site 1220533002252 catalytic residues [active] 1220533002253 NAD binding pocket [chemical binding]; other site 1220533002254 phosphate binding motif [ion binding]; other site 1220533002255 beta-alpha-beta structure motif; other site 1220533002256 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1220533002257 Sulfatase; Region: Sulfatase; pfam00884 1220533002258 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1220533002259 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1220533002260 substrate binding site; other site 1220533002261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1220533002262 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1220533002263 NAD(P) binding site [chemical binding]; other site 1220533002264 active site 1220533002265 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1220533002266 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1220533002267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533002268 active site 1220533002269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1220533002270 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1220533002271 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533002272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002273 putative substrate translocation pore; other site 1220533002274 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1220533002275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533002276 active site 1220533002277 motif I; other site 1220533002278 motif II; other site 1220533002279 amino acid transporter; Region: 2A0306; TIGR00909 1220533002280 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1220533002281 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1220533002282 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1220533002283 NAD(P) binding site [chemical binding]; other site 1220533002284 catalytic residues [active] 1220533002285 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1220533002286 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533002287 dimer interface [polypeptide binding]; other site 1220533002288 putative CheW interface [polypeptide binding]; other site 1220533002289 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1220533002290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1220533002291 Walker A/P-loop; other site 1220533002292 ATP binding site [chemical binding]; other site 1220533002293 Q-loop/lid; other site 1220533002294 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533002295 ABC transporter signature motif; other site 1220533002296 Walker B; other site 1220533002297 D-loop; other site 1220533002298 ABC transporter; Region: ABC_tran_2; pfam12848 1220533002299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533002300 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1220533002301 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1220533002302 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1220533002303 DNA binding residues [nucleotide binding] 1220533002304 putative dimer interface [polypeptide binding]; other site 1220533002305 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1220533002306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002307 putative substrate translocation pore; other site 1220533002308 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1220533002309 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533002310 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533002311 ABC transporter; Region: ABC_tran_2; pfam12848 1220533002312 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533002313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1220533002314 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1220533002315 ATP binding site [chemical binding]; other site 1220533002316 putative Mg++ binding site [ion binding]; other site 1220533002317 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533002318 nucleotide binding region [chemical binding]; other site 1220533002319 ATP-binding site [chemical binding]; other site 1220533002320 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1220533002321 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1220533002322 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1220533002323 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1220533002324 NAD(P) binding site [chemical binding]; other site 1220533002325 substrate binding site [chemical binding]; other site 1220533002326 dimer interface [polypeptide binding]; other site 1220533002327 H+ Antiporter protein; Region: 2A0121; TIGR00900 1220533002328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002329 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1220533002330 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1220533002331 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1220533002332 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1220533002333 Walker A/P-loop; other site 1220533002334 ATP binding site [chemical binding]; other site 1220533002335 Q-loop/lid; other site 1220533002336 ABC transporter signature motif; other site 1220533002337 Walker B; other site 1220533002338 D-loop; other site 1220533002339 H-loop/switch region; other site 1220533002340 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1220533002341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533002342 ABC-ATPase subunit interface; other site 1220533002343 dimer interface [polypeptide binding]; other site 1220533002344 putative PBP binding regions; other site 1220533002345 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1220533002346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533002347 ABC-ATPase subunit interface; other site 1220533002348 dimer interface [polypeptide binding]; other site 1220533002349 putative PBP binding regions; other site 1220533002350 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1220533002351 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1220533002352 siderophore binding site; other site 1220533002353 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1220533002354 Heat induced stress protein YflT; Region: YflT; pfam11181 1220533002355 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1220533002356 Amb_all domain; Region: Amb_all; smart00656 1220533002357 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1220533002358 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1220533002359 transmembrane helices; other site 1220533002360 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1220533002361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533002362 ATP binding site [chemical binding]; other site 1220533002363 Mg2+ binding site [ion binding]; other site 1220533002364 G-X-G motif; other site 1220533002365 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1220533002366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533002367 active site 1220533002368 phosphorylation site [posttranslational modification] 1220533002369 intermolecular recognition site; other site 1220533002370 dimerization interface [polypeptide binding]; other site 1220533002371 Transcriptional regulator; Region: CitT; pfam12431 1220533002372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1220533002373 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1220533002374 Citrate transporter; Region: CitMHS; pfam03600 1220533002375 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1220533002376 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1220533002377 active site 1220533002378 dimer interface [polypeptide binding]; other site 1220533002379 acylphosphatase; Provisional; Region: PRK14420 1220533002380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1220533002381 MOSC domain; Region: MOSC; pfam03473 1220533002382 3-alpha domain; Region: 3-alpha; pfam03475 1220533002383 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1220533002384 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1220533002385 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1220533002386 active site 1220533002387 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1220533002388 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1220533002389 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1220533002390 active site turn [active] 1220533002391 phosphorylation site [posttranslational modification] 1220533002392 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1220533002393 Sulfatase; Region: Sulfatase; pfam00884 1220533002394 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1220533002395 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1220533002396 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1220533002397 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1220533002398 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1220533002399 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1220533002400 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1220533002401 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1220533002402 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1220533002403 active site turn [active] 1220533002404 phosphorylation site [posttranslational modification] 1220533002405 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1220533002406 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1220533002407 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1220533002408 Ca binding site [ion binding]; other site 1220533002409 active site 1220533002410 catalytic site [active] 1220533002411 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1220533002412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533002413 DNA-binding site [nucleotide binding]; DNA binding site 1220533002414 UTRA domain; Region: UTRA; pfam07702 1220533002415 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1220533002416 dimer interface [polypeptide binding]; other site 1220533002417 FMN binding site [chemical binding]; other site 1220533002418 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1220533002419 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1220533002420 active site 1220533002421 metal binding site [ion binding]; metal-binding site 1220533002422 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1220533002423 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1220533002424 active site 1220533002425 metal binding site [ion binding]; metal-binding site 1220533002426 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1220533002427 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1220533002428 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1220533002429 proposed catalytic triad [active] 1220533002430 conserved cys residue [active] 1220533002431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533002433 putative substrate translocation pore; other site 1220533002434 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1220533002435 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1220533002436 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1220533002437 active site 1220533002438 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 1220533002439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533002441 putative substrate translocation pore; other site 1220533002442 calcium/proton exchanger (cax); Region: cax; TIGR00378 1220533002443 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1220533002444 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1220533002445 YfkD-like protein; Region: YfkD; pfam14167 1220533002446 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1220533002447 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1220533002448 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1220533002449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533002450 FeS/SAM binding site; other site 1220533002451 YfkB-like domain; Region: YfkB; pfam08756 1220533002452 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1220533002453 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1220533002454 NodB motif; other site 1220533002455 active site 1220533002456 catalytic site [active] 1220533002457 Cd binding site [ion binding]; other site 1220533002458 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1220533002459 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1220533002460 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1220533002461 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1220533002462 oligomer interface [polypeptide binding]; other site 1220533002463 metal binding site [ion binding]; metal-binding site 1220533002464 metal binding site [ion binding]; metal-binding site 1220533002465 putative Cl binding site [ion binding]; other site 1220533002466 aspartate ring; other site 1220533002467 basic sphincter; other site 1220533002468 hydrophobic gate; other site 1220533002469 periplasmic entrance; other site 1220533002470 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1220533002471 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1220533002472 minor groove reading motif; other site 1220533002473 helix-hairpin-helix signature motif; other site 1220533002474 substrate binding pocket [chemical binding]; other site 1220533002475 active site 1220533002476 TRAM domain; Region: TRAM; pfam01938 1220533002477 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1220533002478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533002479 S-adenosylmethionine binding site [chemical binding]; other site 1220533002480 YfzA-like protein; Region: YfzA; pfam14118 1220533002481 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1220533002482 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1220533002483 FMN binding site [chemical binding]; other site 1220533002484 active site 1220533002485 catalytic residues [active] 1220533002486 substrate binding site [chemical binding]; other site 1220533002487 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 1220533002488 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1220533002489 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1220533002490 tetramer interface [polypeptide binding]; other site 1220533002491 TPP-binding site [chemical binding]; other site 1220533002492 heterodimer interface [polypeptide binding]; other site 1220533002493 phosphorylation loop region [posttranslational modification] 1220533002494 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1220533002495 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1220533002496 alpha subunit interface [polypeptide binding]; other site 1220533002497 TPP binding site [chemical binding]; other site 1220533002498 heterodimer interface [polypeptide binding]; other site 1220533002499 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1220533002500 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1220533002501 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1220533002502 E3 interaction surface; other site 1220533002503 lipoyl attachment site [posttranslational modification]; other site 1220533002504 e3 binding domain; Region: E3_binding; pfam02817 1220533002505 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1220533002506 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1220533002507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533002508 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1220533002509 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1220533002510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533002511 Walker A motif; other site 1220533002512 ATP binding site [chemical binding]; other site 1220533002513 Walker B motif; other site 1220533002514 arginine finger; other site 1220533002515 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1220533002516 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 1220533002517 hypothetical protein; Provisional; Region: PRK02237 1220533002518 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1220533002519 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1220533002520 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1220533002521 NAD binding site [chemical binding]; other site 1220533002522 sugar binding site [chemical binding]; other site 1220533002523 divalent metal binding site [ion binding]; other site 1220533002524 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1220533002525 dimer interface [polypeptide binding]; other site 1220533002526 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1220533002527 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1220533002528 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1220533002529 putative active site [active] 1220533002530 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1220533002531 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1220533002532 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1220533002533 active site turn [active] 1220533002534 phosphorylation site [posttranslational modification] 1220533002535 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1220533002536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533002537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1220533002538 Walker A/P-loop; other site 1220533002539 ATP binding site [chemical binding]; other site 1220533002540 Q-loop/lid; other site 1220533002541 ABC transporter signature motif; other site 1220533002542 Walker B; other site 1220533002543 D-loop; other site 1220533002544 H-loop/switch region; other site 1220533002545 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1220533002546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533002547 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1220533002548 Walker A/P-loop; other site 1220533002549 ATP binding site [chemical binding]; other site 1220533002550 Q-loop/lid; other site 1220533002551 ABC transporter signature motif; other site 1220533002552 Walker B; other site 1220533002553 D-loop; other site 1220533002554 H-loop/switch region; other site 1220533002555 Predicted membrane protein [Function unknown]; Region: COG2259 1220533002556 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1220533002557 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1220533002558 putative metal binding site [ion binding]; other site 1220533002559 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1220533002560 active site 1220533002561 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1220533002562 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1220533002563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533002564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533002565 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1220533002566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002567 putative substrate translocation pore; other site 1220533002568 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1220533002569 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1220533002570 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1220533002571 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1220533002572 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1220533002573 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1220533002574 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1220533002575 Histidine kinase; Region: HisKA_3; pfam07730 1220533002576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533002577 ATP binding site [chemical binding]; other site 1220533002578 Mg2+ binding site [ion binding]; other site 1220533002579 G-X-G motif; other site 1220533002580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533002581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533002582 active site 1220533002583 phosphorylation site [posttranslational modification] 1220533002584 intermolecular recognition site; other site 1220533002585 dimerization interface [polypeptide binding]; other site 1220533002586 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533002587 DNA binding residues [nucleotide binding] 1220533002588 dimerization interface [polypeptide binding]; other site 1220533002589 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1220533002590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1220533002591 Walker A/P-loop; other site 1220533002592 ATP binding site [chemical binding]; other site 1220533002593 Q-loop/lid; other site 1220533002594 ABC transporter signature motif; other site 1220533002595 Walker B; other site 1220533002596 D-loop; other site 1220533002597 H-loop/switch region; other site 1220533002598 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1220533002599 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1220533002600 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1220533002601 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1220533002602 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1220533002603 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1220533002604 Predicted transcriptional regulators [Transcription]; Region: COG1695 1220533002605 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1220533002606 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1220533002607 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1220533002608 Lipase (class 2); Region: Lipase_2; pfam01674 1220533002609 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1220533002610 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1220533002611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533002612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533002613 H+ Antiporter protein; Region: 2A0121; TIGR00900 1220533002614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002615 putative substrate translocation pore; other site 1220533002616 metal-dependent hydrolase; Provisional; Region: PRK13291 1220533002617 DinB superfamily; Region: DinB_2; pfam12867 1220533002618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002619 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533002620 putative substrate translocation pore; other site 1220533002621 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533002622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533002623 putative Zn2+ binding site [ion binding]; other site 1220533002624 putative DNA binding site [nucleotide binding]; other site 1220533002625 Predicted integral membrane protein [Function unknown]; Region: COG0392 1220533002626 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1220533002627 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1220533002628 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1220533002629 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1220533002630 siderophore binding site; other site 1220533002631 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1220533002632 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533002633 ABC-ATPase subunit interface; other site 1220533002634 dimer interface [polypeptide binding]; other site 1220533002635 putative PBP binding regions; other site 1220533002636 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1220533002637 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533002638 ABC-ATPase subunit interface; other site 1220533002639 dimer interface [polypeptide binding]; other site 1220533002640 putative PBP binding regions; other site 1220533002641 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1220533002642 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1220533002643 putative FMN binding site [chemical binding]; other site 1220533002644 YfhD-like protein; Region: YfhD; pfam14151 1220533002645 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1220533002646 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1220533002647 putative NAD(P) binding site [chemical binding]; other site 1220533002648 putative active site [active] 1220533002649 recombination regulator RecX; Provisional; Region: recX; PRK14135 1220533002650 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1220533002651 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1220533002652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002653 putative substrate translocation pore; other site 1220533002654 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1220533002655 WVELL protein; Region: WVELL; pfam14043 1220533002656 Bacterial SH3 domain; Region: SH3_3; pfam08239 1220533002657 Bacterial SH3 domain; Region: SH3_3; cl17532 1220533002658 Predicted integral membrane protein [Function unknown]; Region: COG5658 1220533002659 SdpI/YhfL protein family; Region: SdpI; pfam13630 1220533002660 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533002661 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1220533002662 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1220533002663 catalytic site [active] 1220533002664 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1220533002665 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1220533002666 Ligand binding site; other site 1220533002667 Putative Catalytic site; other site 1220533002668 DXD motif; other site 1220533002669 Predicted membrane protein [Function unknown]; Region: COG4485 1220533002670 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1220533002671 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1220533002672 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1220533002673 minor groove reading motif; other site 1220533002674 helix-hairpin-helix signature motif; other site 1220533002675 substrate binding pocket [chemical binding]; other site 1220533002676 active site 1220533002677 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1220533002678 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1220533002679 DNA binding and oxoG recognition site [nucleotide binding] 1220533002680 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1220533002681 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1220533002682 putative NAD(P) binding site [chemical binding]; other site 1220533002683 active site 1220533002684 YgaB-like protein; Region: YgaB; pfam14182 1220533002685 hypothetical protein; Provisional; Region: PRK13662 1220533002686 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1220533002687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533002688 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1220533002689 Walker A/P-loop; other site 1220533002690 ATP binding site [chemical binding]; other site 1220533002691 Q-loop/lid; other site 1220533002692 ABC transporter signature motif; other site 1220533002693 Walker B; other site 1220533002694 D-loop; other site 1220533002695 H-loop/switch region; other site 1220533002696 Predicted membrane protein [Function unknown]; Region: COG4129 1220533002697 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1220533002698 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1220533002699 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1220533002700 inhibitor-cofactor binding pocket; inhibition site 1220533002701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533002702 catalytic residue [active] 1220533002703 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1220533002704 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1220533002705 catalytic triad [active] 1220533002706 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1220533002707 metal binding site 2 [ion binding]; metal-binding site 1220533002708 putative DNA binding helix; other site 1220533002709 metal binding site 1 [ion binding]; metal-binding site 1220533002710 dimer interface [polypeptide binding]; other site 1220533002711 structural Zn2+ binding site [ion binding]; other site 1220533002712 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1220533002713 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1220533002714 SpoOM protein; Region: Spo0M; pfam07070 1220533002715 Coat F domain; Region: Coat_F; pfam07875 1220533002716 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1220533002717 active site pocket [active] 1220533002718 oxyanion hole [active] 1220533002719 catalytic triad [active] 1220533002720 active site nucleophile [active] 1220533002721 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1220533002722 ThiC-associated domain; Region: ThiC-associated; pfam13667 1220533002723 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1220533002724 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1220533002725 FAD binding domain; Region: FAD_binding_4; pfam01565 1220533002726 Berberine and berberine like; Region: BBE; pfam08031 1220533002727 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1220533002728 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1220533002729 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1220533002730 tetramer interface [polypeptide binding]; other site 1220533002731 heme binding pocket [chemical binding]; other site 1220533002732 NADPH binding site [chemical binding]; other site 1220533002733 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1220533002734 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1220533002735 Walker A/P-loop; other site 1220533002736 ATP binding site [chemical binding]; other site 1220533002737 Q-loop/lid; other site 1220533002738 ABC transporter signature motif; other site 1220533002739 Walker B; other site 1220533002740 D-loop; other site 1220533002741 H-loop/switch region; other site 1220533002742 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1220533002743 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1220533002744 substrate binding pocket [chemical binding]; other site 1220533002745 membrane-bound complex binding site; other site 1220533002746 hinge residues; other site 1220533002747 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1220533002748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533002749 dimer interface [polypeptide binding]; other site 1220533002750 conserved gate region; other site 1220533002751 putative PBP binding loops; other site 1220533002752 ABC-ATPase subunit interface; other site 1220533002753 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1220533002754 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1220533002755 active site 1220533002756 dimer interface [polypeptide binding]; other site 1220533002757 non-prolyl cis peptide bond; other site 1220533002758 insertion regions; other site 1220533002759 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1220533002760 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533002761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533002762 non-specific DNA binding site [nucleotide binding]; other site 1220533002763 salt bridge; other site 1220533002764 sequence-specific DNA binding site [nucleotide binding]; other site 1220533002765 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1220533002766 epoxyqueuosine reductase; Region: TIGR00276 1220533002767 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1220533002768 Putative amidase domain; Region: Amidase_6; pfam12671 1220533002769 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1220533002770 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1220533002771 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1220533002772 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1220533002773 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1220533002774 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1220533002775 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1220533002776 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1220533002777 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533002778 MarR family; Region: MarR; pfam01047 1220533002779 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1220533002780 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1220533002781 carboxyltransferase (CT) interaction site; other site 1220533002782 biotinylation site [posttranslational modification]; other site 1220533002783 HlyD family secretion protein; Region: HlyD_3; pfam13437 1220533002784 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1220533002785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002786 putative substrate translocation pore; other site 1220533002787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533002788 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1220533002789 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1220533002790 Predicted transcriptional regulators [Transcription]; Region: COG1725 1220533002791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533002792 DNA-binding site [nucleotide binding]; DNA binding site 1220533002793 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1220533002794 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1220533002795 Walker A/P-loop; other site 1220533002796 ATP binding site [chemical binding]; other site 1220533002797 Q-loop/lid; other site 1220533002798 ABC transporter signature motif; other site 1220533002799 Walker B; other site 1220533002800 D-loop; other site 1220533002801 H-loop/switch region; other site 1220533002802 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1220533002803 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1220533002804 Walker A/P-loop; other site 1220533002805 ATP binding site [chemical binding]; other site 1220533002806 Q-loop/lid; other site 1220533002807 ABC transporter signature motif; other site 1220533002808 Walker B; other site 1220533002809 D-loop; other site 1220533002810 H-loop/switch region; other site 1220533002811 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1220533002812 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1220533002813 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1220533002814 DNA-binding site [nucleotide binding]; DNA binding site 1220533002815 RNA-binding motif; other site 1220533002816 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1220533002817 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1220533002818 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1220533002819 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1220533002820 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1220533002821 metal binding site [ion binding]; metal-binding site 1220533002822 active site 1220533002823 I-site; other site 1220533002824 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1220533002825 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1220533002826 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1220533002827 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1220533002828 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1220533002829 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1220533002830 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1220533002831 generic binding surface II; other site 1220533002832 generic binding surface I; other site 1220533002833 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1220533002834 generic binding surface II; other site 1220533002835 generic binding surface I; other site 1220533002836 Staphylococcal nuclease homologues; Region: SNc; smart00318 1220533002837 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1220533002838 Catalytic site; other site 1220533002839 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1220533002840 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1220533002841 putative active site [active] 1220533002842 putative metal binding site [ion binding]; other site 1220533002843 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1220533002844 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1220533002845 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1220533002846 active site 1220533002847 catalytic site [active] 1220533002848 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1220533002849 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533002850 RNA binding surface [nucleotide binding]; other site 1220533002851 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1220533002852 active site 1220533002853 FOG: CBS domain [General function prediction only]; Region: COG0517 1220533002854 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1220533002855 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1220533002856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533002857 motif II; other site 1220533002858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533002859 Coenzyme A binding pocket [chemical binding]; other site 1220533002860 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1220533002861 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1220533002862 putative active site [active] 1220533002863 catalytic triad [active] 1220533002864 putative dimer interface [polypeptide binding]; other site 1220533002865 aminotransferase; Validated; Region: PRK07678 1220533002866 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1220533002867 inhibitor-cofactor binding pocket; inhibition site 1220533002868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533002869 catalytic residue [active] 1220533002870 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1220533002871 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1220533002872 amphipathic channel; other site 1220533002873 Asn-Pro-Ala signature motifs; other site 1220533002874 glycerol kinase; Provisional; Region: glpK; PRK00047 1220533002875 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1220533002876 N- and C-terminal domain interface [polypeptide binding]; other site 1220533002877 active site 1220533002878 MgATP binding site [chemical binding]; other site 1220533002879 catalytic site [active] 1220533002880 metal binding site [ion binding]; metal-binding site 1220533002881 glycerol binding site [chemical binding]; other site 1220533002882 homotetramer interface [polypeptide binding]; other site 1220533002883 homodimer interface [polypeptide binding]; other site 1220533002884 FBP binding site [chemical binding]; other site 1220533002885 protein IIAGlc interface [polypeptide binding]; other site 1220533002886 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1220533002887 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1220533002888 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1220533002889 active site 1220533002890 substrate binding site [chemical binding]; other site 1220533002891 metal binding site [ion binding]; metal-binding site 1220533002892 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1220533002893 GAF domain; Region: GAF; pfam01590 1220533002894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1220533002895 Histidine kinase; Region: HisKA_3; pfam07730 1220533002896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533002897 ATP binding site [chemical binding]; other site 1220533002898 Mg2+ binding site [ion binding]; other site 1220533002899 G-X-G motif; other site 1220533002900 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533002901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533002902 active site 1220533002903 phosphorylation site [posttranslational modification] 1220533002904 intermolecular recognition site; other site 1220533002905 dimerization interface [polypeptide binding]; other site 1220533002906 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533002907 DNA binding residues [nucleotide binding] 1220533002908 dimerization interface [polypeptide binding]; other site 1220533002909 Predicted flavoprotein [General function prediction only]; Region: COG0431 1220533002910 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1220533002911 YhdB-like protein; Region: YhdB; pfam14148 1220533002912 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1220533002913 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533002914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533002915 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533002916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533002917 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533002918 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1220533002919 NlpC/P60 family; Region: NLPC_P60; pfam00877 1220533002920 Transcriptional regulator; Region: Rrf2; cl17282 1220533002921 Rrf2 family protein; Region: rrf2_super; TIGR00738 1220533002922 Conserved TM helix; Region: TM_helix; pfam05552 1220533002923 Conserved TM helix; Region: TM_helix; pfam05552 1220533002924 Conserved TM helix; Region: TM_helix; pfam05552 1220533002925 Conserved TM helix; Region: TM_helix; pfam05552 1220533002926 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1220533002927 SpoVR like protein; Region: SpoVR; pfam04293 1220533002928 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1220533002929 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1220533002930 dimer interface [polypeptide binding]; other site 1220533002931 active site 1220533002932 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533002933 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533002934 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533002935 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1220533002936 NlpC/P60 family; Region: NLPC_P60; pfam00877 1220533002937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533002938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533002939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533002940 dimerization interface [polypeptide binding]; other site 1220533002941 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1220533002942 dimer interface [polypeptide binding]; other site 1220533002943 Citrate synthase; Region: Citrate_synt; pfam00285 1220533002944 active site 1220533002945 citrylCoA binding site [chemical binding]; other site 1220533002946 oxalacetate/citrate binding site [chemical binding]; other site 1220533002947 coenzyme A binding site [chemical binding]; other site 1220533002948 catalytic triad [active] 1220533002949 short chain dehydrogenase; Provisional; Region: PRK06701 1220533002950 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1220533002951 NAD binding site [chemical binding]; other site 1220533002952 metal binding site [ion binding]; metal-binding site 1220533002953 active site 1220533002954 amino acid transporter; Region: 2A0306; TIGR00909 1220533002955 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1220533002956 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1220533002957 Na2 binding site [ion binding]; other site 1220533002958 putative substrate binding site 1 [chemical binding]; other site 1220533002959 Na binding site 1 [ion binding]; other site 1220533002960 putative substrate binding site 2 [chemical binding]; other site 1220533002961 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1220533002962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533002963 DNA-binding site [nucleotide binding]; DNA binding site 1220533002964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533002965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533002966 homodimer interface [polypeptide binding]; other site 1220533002967 catalytic residue [active] 1220533002968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1220533002969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533002970 Coenzyme A binding pocket [chemical binding]; other site 1220533002971 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1220533002972 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1220533002973 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1220533002974 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533002975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533002976 DNA binding residues [nucleotide binding] 1220533002977 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1220533002978 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1220533002979 active site 1220533002980 catalytic tetrad [active] 1220533002981 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1220533002982 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1220533002983 putative acyl-acceptor binding pocket; other site 1220533002984 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1220533002985 Domain of unknown function DUF21; Region: DUF21; pfam01595 1220533002986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1220533002987 Transporter associated domain; Region: CorC_HlyC; smart01091 1220533002988 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1220533002989 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1220533002990 DNA binding residues [nucleotide binding] 1220533002991 putative dimer interface [polypeptide binding]; other site 1220533002992 aspartate aminotransferase; Provisional; Region: PRK06836 1220533002993 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533002994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533002995 homodimer interface [polypeptide binding]; other site 1220533002996 catalytic residue [active] 1220533002997 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1220533002998 Domain of unknown function DUF21; Region: DUF21; pfam01595 1220533002999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1220533003000 Transporter associated domain; Region: CorC_HlyC; smart01091 1220533003001 camphor resistance protein CrcB; Provisional; Region: PRK14213 1220533003002 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1220533003003 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1220533003004 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1220533003005 active site 1220533003006 catalytic site [active] 1220533003007 metal binding site [ion binding]; metal-binding site 1220533003008 dimer interface [polypeptide binding]; other site 1220533003009 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1220533003010 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1220533003011 NAD-dependent deacetylase; Provisional; Region: PRK00481 1220533003012 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1220533003013 NAD+ binding site [chemical binding]; other site 1220533003014 substrate binding site [chemical binding]; other site 1220533003015 Zn binding site [ion binding]; other site 1220533003016 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1220533003017 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1220533003018 NodB motif; other site 1220533003019 active site 1220533003020 catalytic site [active] 1220533003021 Zn binding site [ion binding]; other site 1220533003022 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1220533003023 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1220533003024 homodimer interface [polypeptide binding]; other site 1220533003025 substrate-cofactor binding pocket; other site 1220533003026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533003027 catalytic residue [active] 1220533003028 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1220533003029 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1220533003030 Ligand Binding Site [chemical binding]; other site 1220533003031 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533003032 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1220533003033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1220533003034 Walker A/P-loop; other site 1220533003035 ATP binding site [chemical binding]; other site 1220533003036 Q-loop/lid; other site 1220533003037 ABC transporter signature motif; other site 1220533003038 Walker B; other site 1220533003039 D-loop; other site 1220533003040 H-loop/switch region; other site 1220533003041 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1220533003042 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1220533003043 NAD binding site [chemical binding]; other site 1220533003044 substrate binding site [chemical binding]; other site 1220533003045 putative active site [active] 1220533003046 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1220533003047 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1220533003048 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1220533003049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1220533003050 hypothetical protein; Provisional; Region: PRK13676 1220533003051 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1220533003052 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1220533003053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533003054 active site 1220533003055 motif I; other site 1220533003056 motif II; other site 1220533003057 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1220533003058 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1220533003059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533003060 FeS/SAM binding site; other site 1220533003061 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1220533003062 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1220533003063 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1220533003064 TrkA-C domain; Region: TrkA_C; pfam02080 1220533003065 enoyl-CoA hydratase; Provisional; Region: PRK07659 1220533003066 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1220533003067 substrate binding site [chemical binding]; other site 1220533003068 oxyanion hole (OAH) forming residues; other site 1220533003069 trimer interface [polypeptide binding]; other site 1220533003070 YhzD-like protein; Region: YhzD; pfam14120 1220533003071 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1220533003072 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1220533003073 Walker A/P-loop; other site 1220533003074 ATP binding site [chemical binding]; other site 1220533003075 Q-loop/lid; other site 1220533003076 ABC transporter signature motif; other site 1220533003077 Walker B; other site 1220533003078 D-loop; other site 1220533003079 H-loop/switch region; other site 1220533003080 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1220533003081 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1220533003082 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1220533003083 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1220533003084 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1220533003085 active site 1220533003086 metal binding site [ion binding]; metal-binding site 1220533003087 DNA binding site [nucleotide binding] 1220533003088 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1220533003089 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1220533003090 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1220533003091 generic binding surface II; other site 1220533003092 generic binding surface I; other site 1220533003093 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1220533003094 Zn2+ binding site [ion binding]; other site 1220533003095 Mg2+ binding site [ion binding]; other site 1220533003096 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1220533003097 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1220533003098 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1220533003099 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1220533003100 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1220533003101 transcriptional regulator Hpr; Provisional; Region: PRK13777 1220533003102 MarR family; Region: MarR; pfam01047 1220533003103 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1220533003104 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1220533003105 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1220533003106 homodimer interface [polypeptide binding]; other site 1220533003107 substrate-cofactor binding pocket; other site 1220533003108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533003109 catalytic residue [active] 1220533003110 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1220533003111 HIT family signature motif; other site 1220533003112 catalytic residue [active] 1220533003113 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1220533003114 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1220533003115 Walker A/P-loop; other site 1220533003116 ATP binding site [chemical binding]; other site 1220533003117 Q-loop/lid; other site 1220533003118 ABC transporter signature motif; other site 1220533003119 Walker B; other site 1220533003120 D-loop; other site 1220533003121 H-loop/switch region; other site 1220533003122 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1220533003123 EcsC protein family; Region: EcsC; pfam12787 1220533003124 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1220533003125 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1220533003126 metal binding site [ion binding]; metal-binding site 1220533003127 dimer interface [polypeptide binding]; other site 1220533003128 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1220533003129 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1220533003130 Transglycosylase; Region: Transgly; pfam00912 1220533003131 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1220533003132 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1220533003133 substrate binding site [chemical binding]; other site 1220533003134 active site 1220533003135 ferrochelatase; Provisional; Region: PRK12435 1220533003136 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1220533003137 C-terminal domain interface [polypeptide binding]; other site 1220533003138 active site 1220533003139 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1220533003140 active site 1220533003141 N-terminal domain interface [polypeptide binding]; other site 1220533003142 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1220533003143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1220533003144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533003145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533003146 Predicted membrane protein [Function unknown]; Region: COG1511 1220533003147 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1220533003148 Pex19 protein family; Region: Pex19; pfam04614 1220533003149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533003150 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1220533003151 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1220533003152 dimer interface [polypeptide binding]; other site 1220533003153 active site 1220533003154 CoA binding pocket [chemical binding]; other site 1220533003155 Predicted membrane protein [Function unknown]; Region: COG4377 1220533003156 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1220533003157 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1220533003158 putative oligomer interface [polypeptide binding]; other site 1220533003159 putative active site [active] 1220533003160 metal binding site [ion binding]; metal-binding site 1220533003161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4405 1220533003162 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1220533003163 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1220533003164 YhfH-like protein; Region: YhfH; pfam14149 1220533003165 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1220533003166 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1220533003167 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1220533003168 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1220533003169 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1220533003170 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1220533003171 NAD(P) binding site [chemical binding]; other site 1220533003172 putative active site [active] 1220533003173 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1220533003174 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1220533003175 acyl-activating enzyme (AAE) consensus motif; other site 1220533003176 putative AMP binding site [chemical binding]; other site 1220533003177 putative active site [active] 1220533003178 putative CoA binding site [chemical binding]; other site 1220533003179 Peptidase family M48; Region: Peptidase_M48; pfam01435 1220533003180 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1220533003181 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1220533003182 active site 1220533003183 catalytic residues [active] 1220533003184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1220533003185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533003186 Coenzyme A binding pocket [chemical binding]; other site 1220533003187 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1220533003188 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1220533003189 putative NADP binding site [chemical binding]; other site 1220533003190 putative dimer interface [polypeptide binding]; other site 1220533003191 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1220533003192 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1220533003193 siderophore binding site; other site 1220533003194 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1220533003195 catalytic core [active] 1220533003196 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1220533003197 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1220533003198 dimer interface [polypeptide binding]; other site 1220533003199 active site 1220533003200 acyl-CoA synthetase; Validated; Region: PRK07638 1220533003201 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1220533003202 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1220533003203 acyl-activating enzyme (AAE) consensus motif; other site 1220533003204 acyl-activating enzyme (AAE) consensus motif; other site 1220533003205 AMP binding site [chemical binding]; other site 1220533003206 active site 1220533003207 CoA binding site [chemical binding]; other site 1220533003208 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1220533003209 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1220533003210 heme-binding site [chemical binding]; other site 1220533003211 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1220533003212 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533003213 dimer interface [polypeptide binding]; other site 1220533003214 putative CheW interface [polypeptide binding]; other site 1220533003215 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1220533003216 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1220533003217 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1220533003218 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1220533003219 [2Fe-2S] cluster binding site [ion binding]; other site 1220533003220 short chain dehydrogenase; Provisional; Region: PRK06701 1220533003221 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1220533003222 NAD binding site [chemical binding]; other site 1220533003223 metal binding site [ion binding]; metal-binding site 1220533003224 active site 1220533003225 IDEAL domain; Region: IDEAL; pfam08858 1220533003226 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1220533003227 oxidoreductase; Provisional; Region: PRK07985 1220533003228 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1220533003229 NAD binding site [chemical binding]; other site 1220533003230 metal binding site [ion binding]; metal-binding site 1220533003231 active site 1220533003232 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1220533003233 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1220533003234 Na binding site [ion binding]; other site 1220533003235 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1220533003236 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1220533003237 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1220533003238 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1220533003239 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1220533003240 Catalytic site [active] 1220533003241 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1220533003242 hypothetical protein; Provisional; Region: PRK08244 1220533003243 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1220533003244 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533003245 MarR family; Region: MarR; pfam01047 1220533003246 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1220533003247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533003248 putative substrate translocation pore; other site 1220533003249 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1220533003250 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1220533003251 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1220533003252 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1220533003253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533003254 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1220533003255 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1220533003256 inhibitor-cofactor binding pocket; inhibition site 1220533003257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533003258 catalytic residue [active] 1220533003259 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1220533003260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533003261 DNA binding site [nucleotide binding] 1220533003262 domain linker motif; other site 1220533003263 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1220533003264 putative dimerization interface [polypeptide binding]; other site 1220533003265 putative ligand binding site [chemical binding]; other site 1220533003266 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1220533003267 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1220533003268 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1220533003269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533003270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533003271 putative substrate translocation pore; other site 1220533003272 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1220533003273 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1220533003274 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1220533003275 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1220533003276 dimerization interface [polypeptide binding]; other site 1220533003277 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1220533003278 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1220533003279 dinuclear metal binding motif [ion binding]; other site 1220533003280 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1220533003281 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1220533003282 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1220533003283 Part of AAA domain; Region: AAA_19; pfam13245 1220533003284 Family description; Region: UvrD_C_2; pfam13538 1220533003285 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1220533003286 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1220533003287 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1220533003288 active site 1220533003289 metal binding site [ion binding]; metal-binding site 1220533003290 DNA binding site [nucleotide binding] 1220533003291 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1220533003292 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1220533003293 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1220533003294 Walker A/P-loop; other site 1220533003295 ATP binding site [chemical binding]; other site 1220533003296 Q-loop/lid; other site 1220533003297 ABC transporter signature motif; other site 1220533003298 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1220533003299 ABC transporter signature motif; other site 1220533003300 Walker B; other site 1220533003301 D-loop; other site 1220533003302 H-loop/switch region; other site 1220533003303 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1220533003304 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1220533003305 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1220533003306 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1220533003307 Spore germination protein GerPC; Region: GerPC; pfam10737 1220533003308 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1220533003309 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1220533003310 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1220533003311 CotH protein; Region: CotH; pfam08757 1220533003312 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1220533003313 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1220533003314 hypothetical protein; Provisional; Region: PRK13673 1220533003315 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1220533003316 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1220533003317 active site 1220533003318 catalytic triad [active] 1220533003319 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1220533003320 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1220533003321 active site 1220533003322 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1220533003323 dimer interface [polypeptide binding]; other site 1220533003324 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1220533003325 Ligand Binding Site [chemical binding]; other site 1220533003326 Molecular Tunnel; other site 1220533003327 DinB family; Region: DinB; cl17821 1220533003328 DinB superfamily; Region: DinB_2; pfam12867 1220533003329 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1220533003330 substrate binding pocket [chemical binding]; other site 1220533003331 aspartate-rich region 2; other site 1220533003332 substrate-Mg2+ binding site; other site 1220533003333 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1220533003334 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1220533003335 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1220533003336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533003337 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533003338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533003339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1220533003340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533003341 DNA binding site [nucleotide binding] 1220533003342 domain linker motif; other site 1220533003343 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1220533003344 dimerization interface [polypeptide binding]; other site 1220533003345 ligand binding site [chemical binding]; other site 1220533003346 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1220533003347 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1220533003348 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1220533003349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1220533003350 Lysine efflux permease [General function prediction only]; Region: COG1279 1220533003351 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1220533003352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533003353 DNA-binding site [nucleotide binding]; DNA binding site 1220533003354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533003355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533003356 homodimer interface [polypeptide binding]; other site 1220533003357 catalytic residue [active] 1220533003358 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1220533003359 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1220533003360 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1220533003361 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533003362 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1220533003363 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1220533003364 ligand-binding site [chemical binding]; other site 1220533003365 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1220533003366 ATP-sulfurylase; Region: ATPS; cd00517 1220533003367 active site 1220533003368 HXXH motif; other site 1220533003369 flexible loop; other site 1220533003370 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1220533003371 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1220533003372 Active Sites [active] 1220533003373 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1220533003374 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1220533003375 (2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809 1220533003376 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1220533003377 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533003378 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1220533003379 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1220533003380 active site pocket [active] 1220533003381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533003382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533003383 putative substrate translocation pore; other site 1220533003384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1220533003385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533003386 Coenzyme A binding pocket [chemical binding]; other site 1220533003387 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1220533003388 Coenzyme A binding pocket [chemical binding]; other site 1220533003389 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1220533003390 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1220533003391 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1220533003392 FAD binding site [chemical binding]; other site 1220533003393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1220533003394 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1220533003395 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1220533003396 S1 domain; Region: S1_2; pfam13509 1220533003397 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1220533003398 RNA binding site [nucleotide binding]; other site 1220533003399 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1220533003400 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1220533003401 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1220533003402 Predicted transcriptional regulators [Transcription]; Region: COG1695 1220533003403 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1220533003404 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1220533003405 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1220533003406 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1220533003407 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1220533003408 active site 1220533003409 Zn binding site [ion binding]; other site 1220533003410 EDD domain protein, DegV family; Region: DegV; TIGR00762 1220533003411 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1220533003412 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1220533003413 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533003414 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533003415 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1220533003416 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1220533003417 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1220533003418 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1220533003419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533003420 motif II; other site 1220533003421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533003422 esterase; Provisional; Region: PRK10566 1220533003423 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1220533003424 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1220533003425 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1220533003426 FAD binding domain; Region: FAD_binding_4; pfam01565 1220533003427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533003428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533003429 putative substrate translocation pore; other site 1220533003430 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1220533003431 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1220533003432 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1220533003433 heterotetramer interface [polypeptide binding]; other site 1220533003434 active site pocket [active] 1220533003435 cleavage site 1220533003436 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1220533003437 nucleotide binding site [chemical binding]; other site 1220533003438 N-acetyl-L-glutamate binding site [chemical binding]; other site 1220533003439 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1220533003440 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1220533003441 inhibitor-cofactor binding pocket; inhibition site 1220533003442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533003443 catalytic residue [active] 1220533003444 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1220533003445 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1220533003446 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1220533003447 catalytic site [active] 1220533003448 subunit interface [polypeptide binding]; other site 1220533003449 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1220533003450 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1220533003451 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1220533003452 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1220533003453 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1220533003454 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1220533003455 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1220533003456 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1220533003457 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1220533003458 YjzC-like protein; Region: YjzC; pfam14168 1220533003459 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1220533003460 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1220533003461 UDP-apiose/xylose synthase; Region: PLN02427 1220533003462 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1220533003463 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1220533003464 putative ligand binding site [chemical binding]; other site 1220533003465 ComZ; Region: ComZ; pfam10815 1220533003466 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1220533003467 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1220533003468 dimer interface [polypeptide binding]; other site 1220533003469 active site 1220533003470 CoA binding pocket [chemical binding]; other site 1220533003471 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1220533003472 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1220533003473 dimer interface [polypeptide binding]; other site 1220533003474 active site 1220533003475 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1220533003476 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1220533003477 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1220533003478 Walker A/P-loop; other site 1220533003479 ATP binding site [chemical binding]; other site 1220533003480 Q-loop/lid; other site 1220533003481 ABC transporter signature motif; other site 1220533003482 Walker B; other site 1220533003483 D-loop; other site 1220533003484 H-loop/switch region; other site 1220533003485 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1220533003486 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1220533003487 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1220533003488 Walker A/P-loop; other site 1220533003489 ATP binding site [chemical binding]; other site 1220533003490 Q-loop/lid; other site 1220533003491 ABC transporter signature motif; other site 1220533003492 Walker B; other site 1220533003493 D-loop; other site 1220533003494 H-loop/switch region; other site 1220533003495 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1220533003496 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1220533003497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533003498 dimer interface [polypeptide binding]; other site 1220533003499 conserved gate region; other site 1220533003500 putative PBP binding loops; other site 1220533003501 ABC-ATPase subunit interface; other site 1220533003502 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1220533003503 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1220533003504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533003505 dimer interface [polypeptide binding]; other site 1220533003506 conserved gate region; other site 1220533003507 putative PBP binding loops; other site 1220533003508 ABC-ATPase subunit interface; other site 1220533003509 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1220533003510 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1220533003511 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1220533003512 active site 1220533003513 HIGH motif; other site 1220533003514 dimer interface [polypeptide binding]; other site 1220533003515 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1220533003516 KMSKS motif; other site 1220533003517 T-box; B657_miscRNA13 1220533003518 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1220533003519 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1220533003520 peptide binding site [polypeptide binding]; other site 1220533003521 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1220533003522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533003523 dimer interface [polypeptide binding]; other site 1220533003524 conserved gate region; other site 1220533003525 putative PBP binding loops; other site 1220533003526 ABC-ATPase subunit interface; other site 1220533003527 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1220533003528 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1220533003529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533003530 dimer interface [polypeptide binding]; other site 1220533003531 conserved gate region; other site 1220533003532 putative PBP binding loops; other site 1220533003533 ABC-ATPase subunit interface; other site 1220533003534 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1220533003535 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1220533003536 Walker A/P-loop; other site 1220533003537 ATP binding site [chemical binding]; other site 1220533003538 Q-loop/lid; other site 1220533003539 ABC transporter signature motif; other site 1220533003540 Walker B; other site 1220533003541 D-loop; other site 1220533003542 H-loop/switch region; other site 1220533003543 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1220533003544 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1220533003545 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1220533003546 Walker A/P-loop; other site 1220533003547 ATP binding site [chemical binding]; other site 1220533003548 Q-loop/lid; other site 1220533003549 ABC transporter signature motif; other site 1220533003550 Walker B; other site 1220533003551 D-loop; other site 1220533003552 H-loop/switch region; other site 1220533003553 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1220533003554 H+ Antiporter protein; Region: 2A0121; TIGR00900 1220533003555 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1220533003556 ArsC family; Region: ArsC; pfam03960 1220533003557 putative catalytic residues [active] 1220533003558 thiol/disulfide switch; other site 1220533003559 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1220533003560 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1220533003561 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 1220533003562 oligoendopeptidase F; Region: pepF; TIGR00181 1220533003563 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1220533003564 active site 1220533003565 Zn binding site [ion binding]; other site 1220533003566 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1220533003567 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1220533003568 catalytic residues [active] 1220533003569 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1220533003570 apolar tunnel; other site 1220533003571 heme binding site [chemical binding]; other site 1220533003572 dimerization interface [polypeptide binding]; other site 1220533003573 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1220533003574 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1220533003575 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1220533003576 catalytic residue [active] 1220533003577 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1220533003578 putative active site [active] 1220533003579 putative metal binding residues [ion binding]; other site 1220533003580 signature motif; other site 1220533003581 putative triphosphate binding site [ion binding]; other site 1220533003582 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1220533003583 synthetase active site [active] 1220533003584 NTP binding site [chemical binding]; other site 1220533003585 metal binding site [ion binding]; metal-binding site 1220533003586 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1220533003587 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1220533003588 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1220533003589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1220533003590 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1220533003591 active site 1220533003592 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1220533003593 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1220533003594 active site 1220533003595 metal binding site [ion binding]; metal-binding site 1220533003596 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1220533003597 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1220533003598 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1220533003599 TrkA-N domain; Region: TrkA_N; pfam02254 1220533003600 TrkA-C domain; Region: TrkA_C; pfam02080 1220533003601 thiaminase II; Region: salvage_TenA; TIGR04306 1220533003602 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1220533003603 thiamine phosphate binding site [chemical binding]; other site 1220533003604 active site 1220533003605 pyrophosphate binding site [ion binding]; other site 1220533003606 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1220533003607 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1220533003608 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1220533003609 thiS-thiF/thiG interaction site; other site 1220533003610 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1220533003611 ThiS interaction site; other site 1220533003612 putative active site [active] 1220533003613 tetramer interface [polypeptide binding]; other site 1220533003614 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1220533003615 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1220533003616 ATP binding site [chemical binding]; other site 1220533003617 substrate interface [chemical binding]; other site 1220533003618 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1220533003619 dimer interface [polypeptide binding]; other site 1220533003620 substrate binding site [chemical binding]; other site 1220533003621 ATP binding site [chemical binding]; other site 1220533003622 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1220533003623 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1220533003624 NAD binding site [chemical binding]; other site 1220533003625 homotetramer interface [polypeptide binding]; other site 1220533003626 homodimer interface [polypeptide binding]; other site 1220533003627 substrate binding site [chemical binding]; other site 1220533003628 active site 1220533003629 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1220533003630 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1220533003631 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1220533003632 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1220533003633 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1220533003634 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1220533003635 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1220533003636 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1220533003637 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1220533003638 Part of AAA domain; Region: AAA_19; pfam13245 1220533003639 Family description; Region: UvrD_C_2; pfam13538 1220533003640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533003641 Coenzyme A binding pocket [chemical binding]; other site 1220533003642 hypothetical protein; Provisional; Region: PRK13679 1220533003643 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1220533003644 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1220533003645 Putative esterase; Region: Esterase; pfam00756 1220533003646 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1220533003647 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1220533003648 homodimer interface [polypeptide binding]; other site 1220533003649 substrate-cofactor binding pocket; other site 1220533003650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533003651 catalytic residue [active] 1220533003652 cystathionine beta-lyase; Provisional; Region: PRK08064 1220533003653 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1220533003654 homodimer interface [polypeptide binding]; other site 1220533003655 substrate-cofactor binding pocket; other site 1220533003656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533003657 catalytic residue [active] 1220533003658 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1220533003659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1220533003660 Predicted integral membrane protein [Function unknown]; Region: COG5505 1220533003661 Putative amidase domain; Region: Amidase_6; pfam12671 1220533003662 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1220533003663 YjcQ protein; Region: YjcQ; pfam09639 1220533003664 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1220533003665 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1220533003666 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1220533003667 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1220533003668 classical (c) SDRs; Region: SDR_c; cd05233 1220533003669 NAD(P) binding site [chemical binding]; other site 1220533003670 active site 1220533003671 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1220533003672 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1220533003673 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1220533003674 HTH domain; Region: HTH_11; pfam08279 1220533003675 PRD domain; Region: PRD; pfam00874 1220533003676 PRD domain; Region: PRD; pfam00874 1220533003677 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1220533003678 active site 1220533003679 P-loop; other site 1220533003680 phosphorylation site [posttranslational modification] 1220533003681 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1220533003682 active site 1220533003683 phosphorylation site [posttranslational modification] 1220533003684 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1220533003685 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1220533003686 active site 1220533003687 P-loop; other site 1220533003688 phosphorylation site [posttranslational modification] 1220533003689 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1220533003690 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1220533003691 active site 1220533003692 phosphorylation site [posttranslational modification] 1220533003693 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1220533003694 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1220533003695 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1220533003696 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1220533003697 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1220533003698 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1220533003699 putative deacylase active site [active] 1220533003700 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1220533003701 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1220533003702 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 1220533003703 UbiA prenyltransferase family; Region: UbiA; pfam01040 1220533003704 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1220533003705 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1220533003706 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1220533003707 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 1220533003708 NodB motif; other site 1220533003709 active site 1220533003710 catalytic site [active] 1220533003711 Zn binding site [ion binding]; other site 1220533003712 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1220533003713 Putative motility protein; Region: YjfB_motility; pfam14070 1220533003714 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1220533003715 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1220533003716 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1220533003717 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1220533003718 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1220533003719 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1220533003720 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1220533003721 4Fe-4S binding domain; Region: Fer4; pfam00037 1220533003722 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1220533003723 [4Fe-4S] binding site [ion binding]; other site 1220533003724 molybdopterin cofactor binding site; other site 1220533003725 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1220533003726 molybdopterin cofactor binding site; other site 1220533003727 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1220533003728 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1220533003729 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1220533003730 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1220533003731 nudix motif; other site 1220533003732 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1220533003733 Cytochrome P450; Region: p450; cl12078 1220533003734 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1220533003735 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1220533003736 active site 1220533003737 TDP-binding site; other site 1220533003738 acceptor substrate-binding pocket; other site 1220533003739 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1220533003740 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1220533003741 active site 1220533003742 TIGR00245 family protein; Region: TIGR00245 1220533003743 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1220533003744 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1220533003745 Walker A/P-loop; other site 1220533003746 ATP binding site [chemical binding]; other site 1220533003747 Q-loop/lid; other site 1220533003748 ABC transporter signature motif; other site 1220533003749 Walker B; other site 1220533003750 D-loop; other site 1220533003751 H-loop/switch region; other site 1220533003752 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1220533003753 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1220533003754 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1220533003755 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1220533003756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533003757 Glucuronate isomerase; Region: UxaC; pfam02614 1220533003758 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1220533003759 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1220533003760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533003761 putative substrate translocation pore; other site 1220533003762 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 1220533003763 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1220533003764 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1220533003765 putative NAD(P) binding site [chemical binding]; other site 1220533003766 catalytic Zn binding site [ion binding]; other site 1220533003767 structural Zn binding site [ion binding]; other site 1220533003768 mannonate dehydratase; Provisional; Region: PRK03906 1220533003769 mannonate dehydratase; Region: uxuA; TIGR00695 1220533003770 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1220533003771 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1220533003772 putative NAD(P) binding site [chemical binding]; other site 1220533003773 active site 1220533003774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533003775 D-galactonate transporter; Region: 2A0114; TIGR00893 1220533003776 putative substrate translocation pore; other site 1220533003777 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1220533003778 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533003779 DNA binding site [nucleotide binding] 1220533003780 domain linker motif; other site 1220533003781 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1220533003782 dimerization interface [polypeptide binding]; other site 1220533003783 ligand binding site [chemical binding]; other site 1220533003784 altronate oxidoreductase; Provisional; Region: PRK03643 1220533003785 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1220533003786 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1220533003787 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1220533003788 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1220533003789 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1220533003790 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1220533003791 DinB family; Region: DinB; pfam05163 1220533003792 DinB superfamily; Region: DinB_2; pfam12867 1220533003793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533003794 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1220533003795 Walker A motif; other site 1220533003796 ATP binding site [chemical binding]; other site 1220533003797 Walker B motif; other site 1220533003798 arginine finger; other site 1220533003799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533003800 binding surface 1220533003801 TPR motif; other site 1220533003802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533003803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533003804 binding surface 1220533003805 TPR motif; other site 1220533003806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1220533003807 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1220533003808 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1220533003809 amidase catalytic site [active] 1220533003810 Zn binding residues [ion binding]; other site 1220533003811 substrate binding site [chemical binding]; other site 1220533003812 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1220533003813 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533003814 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1220533003815 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1220533003816 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1220533003817 pentamer interface [polypeptide binding]; other site 1220533003818 dodecaamer interface [polypeptide binding]; other site 1220533003819 Phage-related replication protein [General function prediction only]; Region: COG4195 1220533003820 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1220533003821 dimanganese center [ion binding]; other site 1220533003822 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1220533003823 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533003824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533003825 non-specific DNA binding site [nucleotide binding]; other site 1220533003826 salt bridge; other site 1220533003827 sequence-specific DNA binding site [nucleotide binding]; other site 1220533003828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1220533003829 putative Zn2+ binding site [ion binding]; other site 1220533003830 putative DNA binding site [nucleotide binding]; other site 1220533003831 hypothetical protein; Provisional; Region: PRK06921 1220533003832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533003833 Walker A motif; other site 1220533003834 ATP binding site [chemical binding]; other site 1220533003835 Walker B motif; other site 1220533003836 positive control sigma-like factor; Validated; Region: PRK06930 1220533003837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533003838 DNA binding residues [nucleotide binding] 1220533003839 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1220533003840 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1220533003841 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1220533003842 Terminase-like family; Region: Terminase_6; pfam03237 1220533003843 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1220533003844 Phage capsid family; Region: Phage_capsid; pfam05065 1220533003845 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1220533003846 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1220533003847 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1220533003848 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1220533003849 Phage XkdN-like protein; Region: XkdN; pfam08890 1220533003850 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1220533003851 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1220533003852 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1220533003853 catalytic residue [active] 1220533003854 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1220533003855 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533003856 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1220533003857 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1220533003858 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1220533003859 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1220533003860 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1220533003861 XkdW protein; Region: XkdW; pfam09636 1220533003862 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1220533003863 Haemolysin XhlA; Region: XhlA; pfam10779 1220533003864 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1220533003865 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1220533003866 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1220533003867 amidase catalytic site [active] 1220533003868 Zn binding residues [ion binding]; other site 1220533003869 substrate binding site [chemical binding]; other site 1220533003870 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533003871 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1220533003872 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1220533003873 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1220533003874 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1220533003875 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1220533003876 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1220533003877 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1220533003878 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1220533003879 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533003880 Zn binding site [ion binding]; other site 1220533003881 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1220533003882 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533003883 Zn binding site [ion binding]; other site 1220533003884 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1220533003885 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1220533003886 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1220533003887 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1220533003888 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1220533003889 Ligand binding site; other site 1220533003890 Putative Catalytic site; other site 1220533003891 DXD motif; other site 1220533003892 Trypsin; Region: Trypsin; pfam00089 1220533003893 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1220533003894 protein binding site [polypeptide binding]; other site 1220533003895 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 1220533003896 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1220533003897 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1220533003898 SxDxEG motif; other site 1220533003899 active site 1220533003900 metal binding site [ion binding]; metal-binding site 1220533003901 homopentamer interface [polypeptide binding]; other site 1220533003902 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1220533003903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533003904 dimer interface [polypeptide binding]; other site 1220533003905 conserved gate region; other site 1220533003906 putative PBP binding loops; other site 1220533003907 ABC-ATPase subunit interface; other site 1220533003908 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1220533003909 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1220533003910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533003911 dimer interface [polypeptide binding]; other site 1220533003912 conserved gate region; other site 1220533003913 putative PBP binding loops; other site 1220533003914 ABC-ATPase subunit interface; other site 1220533003915 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1220533003916 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1220533003917 Walker A/P-loop; other site 1220533003918 ATP binding site [chemical binding]; other site 1220533003919 Q-loop/lid; other site 1220533003920 ABC transporter signature motif; other site 1220533003921 Walker B; other site 1220533003922 D-loop; other site 1220533003923 H-loop/switch region; other site 1220533003924 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1220533003925 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1220533003926 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1220533003927 peptide binding site [polypeptide binding]; other site 1220533003928 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1220533003929 dimer interface [polypeptide binding]; other site 1220533003930 catalytic triad [active] 1220533003931 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1220533003932 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1220533003933 active site 1220533003934 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1220533003935 NlpC/P60 family; Region: NLPC_P60; pfam00877 1220533003936 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1220533003937 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1220533003938 Walker A/P-loop; other site 1220533003939 ATP binding site [chemical binding]; other site 1220533003940 Q-loop/lid; other site 1220533003941 ABC transporter signature motif; other site 1220533003942 Walker B; other site 1220533003943 D-loop; other site 1220533003944 H-loop/switch region; other site 1220533003945 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1220533003946 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1220533003947 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1220533003948 Amidinotransferase; Region: Amidinotransf; pfam02274 1220533003949 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1220533003950 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1220533003951 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1220533003952 heme-binding site [chemical binding]; other site 1220533003953 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1220533003954 FAD binding pocket [chemical binding]; other site 1220533003955 FAD binding motif [chemical binding]; other site 1220533003956 phosphate binding motif [ion binding]; other site 1220533003957 beta-alpha-beta structure motif; other site 1220533003958 NAD binding pocket [chemical binding]; other site 1220533003959 Heme binding pocket [chemical binding]; other site 1220533003960 Predicted membrane protein [Function unknown]; Region: COG2323 1220533003961 DinB superfamily; Region: DinB_2; pfam12867 1220533003962 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1220533003963 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1220533003964 ykkC-yxkD; B657_miscRNA16 1220533003965 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1220533003966 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1220533003967 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1220533003968 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1220533003969 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1220533003970 putative active site [active] 1220533003971 putative substrate binding site [chemical binding]; other site 1220533003972 putative cosubstrate binding site; other site 1220533003973 catalytic site [active] 1220533003974 T-box; B657_miscRNA17 1220533003975 glutamate 5-kinase; Region: proB; TIGR01027 1220533003976 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1220533003977 nucleotide binding site [chemical binding]; other site 1220533003978 homotetrameric interface [polypeptide binding]; other site 1220533003979 putative phosphate binding site [ion binding]; other site 1220533003980 putative allosteric binding site; other site 1220533003981 PUA domain; Region: PUA; pfam01472 1220533003982 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1220533003983 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1220533003984 putative catalytic cysteine [active] 1220533003985 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1220533003986 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533003987 MarR family; Region: MarR; pfam01047 1220533003988 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1220533003989 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1220533003990 nucleoside/Zn binding site; other site 1220533003991 dimer interface [polypeptide binding]; other site 1220533003992 catalytic motif [active] 1220533003993 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1220533003994 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1220533003995 THF binding site; other site 1220533003996 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1220533003997 substrate binding site [chemical binding]; other site 1220533003998 THF binding site; other site 1220533003999 zinc-binding site [ion binding]; other site 1220533004000 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1220533004001 active site 1220533004002 catalytic residues [active] 1220533004003 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1220533004004 Cobalt transport protein; Region: CbiQ; pfam02361 1220533004005 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1220533004006 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1220533004007 Walker A/P-loop; other site 1220533004008 ATP binding site [chemical binding]; other site 1220533004009 Q-loop/lid; other site 1220533004010 ABC transporter signature motif; other site 1220533004011 Walker B; other site 1220533004012 D-loop; other site 1220533004013 H-loop/switch region; other site 1220533004014 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1220533004015 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1220533004016 Walker A/P-loop; other site 1220533004017 ATP binding site [chemical binding]; other site 1220533004018 Q-loop/lid; other site 1220533004019 ABC transporter signature motif; other site 1220533004020 Walker B; other site 1220533004021 D-loop; other site 1220533004022 H-loop/switch region; other site 1220533004023 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1220533004024 YKOF-related Family; Region: Ykof; pfam07615 1220533004025 YKOF-related Family; Region: Ykof; pfam07615 1220533004026 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533004027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533004028 active site 1220533004029 phosphorylation site [posttranslational modification] 1220533004030 intermolecular recognition site; other site 1220533004031 dimerization interface [polypeptide binding]; other site 1220533004032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533004033 DNA binding site [nucleotide binding] 1220533004034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533004035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533004036 dimerization interface [polypeptide binding]; other site 1220533004037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533004038 dimer interface [polypeptide binding]; other site 1220533004039 phosphorylation site [posttranslational modification] 1220533004040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533004041 ATP binding site [chemical binding]; other site 1220533004042 Mg2+ binding site [ion binding]; other site 1220533004043 G-X-G motif; other site 1220533004044 Predicted membrane protein [Function unknown]; Region: COG3212 1220533004045 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1220533004046 Predicted membrane protein [Function unknown]; Region: COG3212 1220533004047 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1220533004048 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1220533004049 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1220533004050 MgtE intracellular N domain; Region: MgtE_N; smart00924 1220533004051 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1220533004052 Divalent cation transporter; Region: MgtE; pfam01769 1220533004053 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1220533004054 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1220533004055 DNA binding residues [nucleotide binding] 1220533004056 putative dimer interface [polypeptide binding]; other site 1220533004057 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533004058 MarR family; Region: MarR; pfam01047 1220533004059 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1220533004060 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1220533004061 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1220533004062 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1220533004063 putative active site [active] 1220533004064 putative metal binding site [ion binding]; other site 1220533004065 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1220533004066 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1220533004067 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1220533004068 Ligand binding site; other site 1220533004069 Putative Catalytic site; other site 1220533004070 DXD motif; other site 1220533004071 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1220533004072 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1220533004073 active site 1220533004074 DNA binding site [nucleotide binding] 1220533004075 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1220533004076 nucleotide binding site [chemical binding]; other site 1220533004077 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1220533004078 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1220533004079 putative DNA binding site [nucleotide binding]; other site 1220533004080 putative homodimer interface [polypeptide binding]; other site 1220533004081 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1220533004082 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1220533004083 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1220533004084 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1220533004085 PAS domain; Region: PAS_9; pfam13426 1220533004086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1220533004087 metal binding site [ion binding]; metal-binding site 1220533004088 active site 1220533004089 I-site; other site 1220533004090 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1220533004091 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1220533004092 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1220533004093 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1220533004094 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1220533004095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533004096 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1220533004097 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1220533004098 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1220533004099 heat shock protein HtpX; Provisional; Region: PRK05457 1220533004100 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1220533004101 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1220533004102 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1220533004103 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1220533004104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533004105 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1220533004106 putative active site [active] 1220533004107 heme pocket [chemical binding]; other site 1220533004108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1220533004109 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1220533004110 putative active site [active] 1220533004111 heme pocket [chemical binding]; other site 1220533004112 PAS domain; Region: PAS; smart00091 1220533004113 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1220533004114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533004115 putative active site [active] 1220533004116 heme pocket [chemical binding]; other site 1220533004117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533004118 dimer interface [polypeptide binding]; other site 1220533004119 phosphorylation site [posttranslational modification] 1220533004120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533004121 ATP binding site [chemical binding]; other site 1220533004122 Mg2+ binding site [ion binding]; other site 1220533004123 G-X-G motif; other site 1220533004124 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1220533004125 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1220533004126 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1220533004127 DNA binding site [nucleotide binding] 1220533004128 active site 1220533004129 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1220533004130 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1220533004131 Predicted kinase [General function prediction only]; Region: COG4857 1220533004132 Phosphotransferase enzyme family; Region: APH; pfam01636 1220533004133 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1220533004134 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1220533004135 putative active site [active] 1220533004136 catalytic triad [active] 1220533004137 putative dimer interface [polypeptide binding]; other site 1220533004138 transaminase; Reviewed; Region: PRK08068 1220533004139 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533004140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533004141 homodimer interface [polypeptide binding]; other site 1220533004142 catalytic residue [active] 1220533004143 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1220533004144 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1220533004145 dimer interface [polypeptide binding]; other site 1220533004146 active site 1220533004147 catalytic residue [active] 1220533004148 metal binding site [ion binding]; metal-binding site 1220533004149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533004150 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1220533004151 motif II; other site 1220533004152 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1220533004153 intersubunit interface [polypeptide binding]; other site 1220533004154 active site 1220533004155 Zn2+ binding site [ion binding]; other site 1220533004156 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1220533004157 Cupin domain; Region: Cupin_2; pfam07883 1220533004158 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1220533004159 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1220533004160 Cache domain; Region: Cache_1; pfam02743 1220533004161 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1220533004162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533004163 dimer interface [polypeptide binding]; other site 1220533004164 phosphorylation site [posttranslational modification] 1220533004165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533004166 ATP binding site [chemical binding]; other site 1220533004167 Mg2+ binding site [ion binding]; other site 1220533004168 G-X-G motif; other site 1220533004169 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533004170 MarR family; Region: MarR; pfam01047 1220533004171 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1220533004172 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1220533004173 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1220533004174 ligand binding site [chemical binding]; other site 1220533004175 flagellar motor protein MotA; Validated; Region: PRK08124 1220533004176 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1220533004177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533004178 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1220533004179 Walker A motif; other site 1220533004180 ATP binding site [chemical binding]; other site 1220533004181 Walker B motif; other site 1220533004182 arginine finger; other site 1220533004183 UvrB/uvrC motif; Region: UVR; pfam02151 1220533004184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533004185 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1220533004186 Walker A motif; other site 1220533004187 ATP binding site [chemical binding]; other site 1220533004188 Walker B motif; other site 1220533004189 arginine finger; other site 1220533004190 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1220533004191 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1220533004192 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1220533004193 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1220533004194 Ligand Binding Site [chemical binding]; other site 1220533004195 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1220533004196 active site 1220533004197 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1220533004198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533004199 FeS/SAM binding site; other site 1220533004200 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1220533004201 Predicted transcriptional regulators [Transcription]; Region: COG1733 1220533004202 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1220533004203 short chain dehydrogenase; Provisional; Region: PRK06500 1220533004204 classical (c) SDRs; Region: SDR_c; cd05233 1220533004205 NAD(P) binding site [chemical binding]; other site 1220533004206 active site 1220533004207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1220533004208 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1220533004209 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1220533004210 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1220533004211 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533004212 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1220533004213 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533004214 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1220533004215 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1220533004216 active site 1220533004217 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1220533004218 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1220533004219 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1220533004220 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1220533004221 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1220533004222 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1220533004223 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1220533004224 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1220533004225 catalytic residues [active] 1220533004226 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1220533004227 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1220533004228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533004229 motif II; other site 1220533004230 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1220533004231 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1220533004232 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1220533004233 active site 1220533004234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1220533004235 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533004236 DNA binding site [nucleotide binding] 1220533004237 domain linker motif; other site 1220533004238 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1220533004239 putative dimerization interface [polypeptide binding]; other site 1220533004240 putative ligand binding site [chemical binding]; other site 1220533004241 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1220533004242 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1220533004243 PRD domain; Region: PRD; pfam00874 1220533004244 PRD domain; Region: PRD; pfam00874 1220533004245 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1220533004246 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1220533004247 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1220533004248 active site turn [active] 1220533004249 phosphorylation site [posttranslational modification] 1220533004250 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1220533004251 HPr interaction site; other site 1220533004252 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1220533004253 active site 1220533004254 phosphorylation site [posttranslational modification] 1220533004255 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1220533004256 dimerization domain swap beta strand [polypeptide binding]; other site 1220533004257 regulatory protein interface [polypeptide binding]; other site 1220533004258 active site 1220533004259 regulatory phosphorylation site [posttranslational modification]; other site 1220533004260 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1220533004261 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1220533004262 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1220533004263 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1220533004264 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1220533004265 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1220533004266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533004267 FeS/SAM binding site; other site 1220533004268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533004269 Coenzyme A binding pocket [chemical binding]; other site 1220533004270 Cache domain; Region: Cache_1; pfam02743 1220533004271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533004272 dimerization interface [polypeptide binding]; other site 1220533004273 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1220533004274 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533004275 dimer interface [polypeptide binding]; other site 1220533004276 putative CheW interface [polypeptide binding]; other site 1220533004277 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1220533004278 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1220533004279 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1220533004280 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1220533004281 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1220533004282 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1220533004283 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1220533004284 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1220533004285 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533004286 putative active site [active] 1220533004287 heme pocket [chemical binding]; other site 1220533004288 PAS fold; Region: PAS; pfam00989 1220533004289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533004290 putative active site [active] 1220533004291 heme pocket [chemical binding]; other site 1220533004292 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1220533004293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533004294 putative active site [active] 1220533004295 heme pocket [chemical binding]; other site 1220533004296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533004297 dimer interface [polypeptide binding]; other site 1220533004298 phosphorylation site [posttranslational modification] 1220533004299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533004300 ATP binding site [chemical binding]; other site 1220533004301 Mg2+ binding site [ion binding]; other site 1220533004302 G-X-G motif; other site 1220533004303 aminotransferase A; Validated; Region: PRK07683 1220533004304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533004305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533004306 homodimer interface [polypeptide binding]; other site 1220533004307 catalytic residue [active] 1220533004308 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1220533004309 putative CheA interaction surface; other site 1220533004310 Response regulator receiver domain; Region: Response_reg; pfam00072 1220533004311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533004312 active site 1220533004313 phosphorylation site [posttranslational modification] 1220533004314 intermolecular recognition site; other site 1220533004315 dimerization interface [polypeptide binding]; other site 1220533004316 YkyB-like protein; Region: YkyB; pfam14177 1220533004317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533004318 H+ Antiporter protein; Region: 2A0121; TIGR00900 1220533004319 putative substrate translocation pore; other site 1220533004320 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533004321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1220533004322 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1220533004323 phosphodiesterase YaeI; Provisional; Region: PRK11340 1220533004324 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1220533004325 putative active site [active] 1220533004326 putative metal binding site [ion binding]; other site 1220533004327 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1220533004328 short chain dehydrogenase; Provisional; Region: PRK07677 1220533004329 NAD(P) binding site [chemical binding]; other site 1220533004330 substrate binding site [chemical binding]; other site 1220533004331 homotetramer interface [polypeptide binding]; other site 1220533004332 active site 1220533004333 homodimer interface [polypeptide binding]; other site 1220533004334 potential frameshift: common BLAST hit: gi|384167205|ref|YP_005548583.1| bacterial lysin 1220533004335 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1220533004336 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1220533004337 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1220533004338 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1220533004339 active site 1220533004340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1220533004341 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1220533004342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1220533004343 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1220533004344 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1220533004345 FOG: CBS domain [General function prediction only]; Region: COG0517 1220533004346 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1220533004347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533004348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533004349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533004350 dimerization interface [polypeptide binding]; other site 1220533004351 flavodoxin; Provisional; Region: PRK06703 1220533004352 BNR repeat-like domain; Region: BNR_2; pfam13088 1220533004353 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1220533004354 flavodoxin, short chain; Region: flav_short; TIGR01753 1220533004355 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1220533004356 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1220533004357 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1220533004358 active site 1220533004359 trimer interface [polypeptide binding]; other site 1220533004360 substrate binding site [chemical binding]; other site 1220533004361 CoA binding site [chemical binding]; other site 1220533004362 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1220533004363 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1220533004364 metal binding site [ion binding]; metal-binding site 1220533004365 putative dimer interface [polypeptide binding]; other site 1220533004366 hypothetical protein; Provisional; Region: PRK03094 1220533004367 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1220533004368 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1220533004369 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1220533004370 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1220533004371 dimer interface [polypeptide binding]; other site 1220533004372 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1220533004373 catalytic triad [active] 1220533004374 peroxidatic and resolving cysteines [active] 1220533004375 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1220533004376 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1220533004377 catalytic residues [active] 1220533004378 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1220533004379 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1220533004380 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1220533004381 GTP binding site; other site 1220533004382 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1220533004383 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1220533004384 ATP binding site [chemical binding]; other site 1220533004385 substrate interface [chemical binding]; other site 1220533004386 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1220533004387 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1220533004388 dimer interface [polypeptide binding]; other site 1220533004389 putative functional site; other site 1220533004390 putative MPT binding site; other site 1220533004391 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1220533004392 Walker A motif; other site 1220533004393 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1220533004394 MoaE homodimer interface [polypeptide binding]; other site 1220533004395 MoaD interaction [polypeptide binding]; other site 1220533004396 active site residues [active] 1220533004397 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1220533004398 MoaE interaction surface [polypeptide binding]; other site 1220533004399 MoeB interaction surface [polypeptide binding]; other site 1220533004400 thiocarboxylated glycine; other site 1220533004401 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1220533004402 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533004403 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1220533004404 Walker A/P-loop; other site 1220533004405 ATP binding site [chemical binding]; other site 1220533004406 Q-loop/lid; other site 1220533004407 ABC transporter signature motif; other site 1220533004408 Walker B; other site 1220533004409 D-loop; other site 1220533004410 H-loop/switch region; other site 1220533004411 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1220533004412 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533004413 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1220533004414 Walker A/P-loop; other site 1220533004415 ATP binding site [chemical binding]; other site 1220533004416 Q-loop/lid; other site 1220533004417 ABC transporter signature motif; other site 1220533004418 Walker B; other site 1220533004419 D-loop; other site 1220533004420 H-loop/switch region; other site 1220533004421 Yip1 domain; Region: Yip1; pfam04893 1220533004422 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1220533004423 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1220533004424 HlyD family secretion protein; Region: HlyD_3; pfam13437 1220533004425 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1220533004426 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1220533004427 Walker A/P-loop; other site 1220533004428 ATP binding site [chemical binding]; other site 1220533004429 Q-loop/lid; other site 1220533004430 ABC transporter signature motif; other site 1220533004431 Walker B; other site 1220533004432 D-loop; other site 1220533004433 H-loop/switch region; other site 1220533004434 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1220533004435 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1220533004436 FtsX-like permease family; Region: FtsX; pfam02687 1220533004437 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1220533004438 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1220533004439 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1220533004440 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1220533004441 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1220533004442 putative substrate binding site [chemical binding]; other site 1220533004443 putative ATP binding site [chemical binding]; other site 1220533004444 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1220533004445 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1220533004446 active site 1220533004447 phosphorylation site [posttranslational modification] 1220533004448 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1220533004449 active site 1220533004450 P-loop; other site 1220533004451 phosphorylation site [posttranslational modification] 1220533004452 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1220533004453 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1220533004454 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1220533004455 Catalytic site [active] 1220533004456 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1220533004457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533004458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533004459 ABC transporter; Region: ABC_tran_2; pfam12848 1220533004460 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1220533004461 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1220533004462 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1220533004463 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1220533004464 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1220533004465 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1220533004466 rod-share determining protein MreBH; Provisional; Region: PRK13929 1220533004467 MreB and similar proteins; Region: MreB_like; cd10225 1220533004468 nucleotide binding site [chemical binding]; other site 1220533004469 Mg binding site [ion binding]; other site 1220533004470 putative protofilament interaction site [polypeptide binding]; other site 1220533004471 RodZ interaction site [polypeptide binding]; other site 1220533004472 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1220533004473 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1220533004474 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1220533004475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533004476 putative active site [active] 1220533004477 heme pocket [chemical binding]; other site 1220533004478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533004479 dimer interface [polypeptide binding]; other site 1220533004480 phosphorylation site [posttranslational modification] 1220533004481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533004482 ATP binding site [chemical binding]; other site 1220533004483 Mg2+ binding site [ion binding]; other site 1220533004484 G-X-G motif; other site 1220533004485 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1220533004486 putative active site pocket [active] 1220533004487 dimerization interface [polypeptide binding]; other site 1220533004488 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1220533004489 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1220533004490 putative active site pocket [active] 1220533004491 dimerization interface [polypeptide binding]; other site 1220533004492 putative catalytic residue [active] 1220533004493 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1220533004494 TrkA-N domain; Region: TrkA_N; pfam02254 1220533004495 TrkA-C domain; Region: TrkA_C; pfam02080 1220533004496 adenine deaminase; Region: ade; TIGR01178 1220533004497 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1220533004498 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1220533004499 active site 1220533004500 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1220533004501 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1220533004502 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1220533004503 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1220533004504 hypothetical protein; Provisional; Region: PRK13667 1220533004505 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1220533004506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533004507 active site 1220533004508 motif I; other site 1220533004509 motif II; other site 1220533004510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533004511 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1220533004512 active site 1220533004513 catalytic residues [active] 1220533004514 metal binding site [ion binding]; metal-binding site 1220533004515 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1220533004516 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1220533004517 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1220533004518 TPP-binding site [chemical binding]; other site 1220533004519 tetramer interface [polypeptide binding]; other site 1220533004520 heterodimer interface [polypeptide binding]; other site 1220533004521 phosphorylation loop region [posttranslational modification] 1220533004522 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1220533004523 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1220533004524 alpha subunit interface [polypeptide binding]; other site 1220533004525 TPP binding site [chemical binding]; other site 1220533004526 heterodimer interface [polypeptide binding]; other site 1220533004527 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1220533004528 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1220533004529 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1220533004530 E3 interaction surface; other site 1220533004531 lipoyl attachment site [posttranslational modification]; other site 1220533004532 e3 binding domain; Region: E3_binding; pfam02817 1220533004533 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1220533004534 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1220533004535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1220533004536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533004537 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1220533004538 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1220533004539 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1220533004540 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1220533004541 homodimer interface [polypeptide binding]; other site 1220533004542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533004543 catalytic residue [active] 1220533004544 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1220533004545 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1220533004546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1220533004547 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1220533004548 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1220533004549 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1220533004550 active site 1220533004551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1220533004552 Coenzyme A binding pocket [chemical binding]; other site 1220533004553 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1220533004554 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1220533004555 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1220533004556 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1220533004557 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1220533004558 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1220533004559 active site 1220533004560 Zn binding site [ion binding]; other site 1220533004561 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533004562 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1220533004563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533004564 DNA binding residues [nucleotide binding] 1220533004565 Predicted integral membrane protein [Function unknown]; Region: COG5660 1220533004566 Putative zinc-finger; Region: zf-HC2; pfam13490 1220533004567 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1220533004568 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1220533004569 G1 box; other site 1220533004570 putative GEF interaction site [polypeptide binding]; other site 1220533004571 GTP/Mg2+ binding site [chemical binding]; other site 1220533004572 Switch I region; other site 1220533004573 G2 box; other site 1220533004574 G3 box; other site 1220533004575 Switch II region; other site 1220533004576 G4 box; other site 1220533004577 G5 box; other site 1220533004578 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1220533004579 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1220533004580 YlaH-like protein; Region: YlaH; pfam14036 1220533004581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 1220533004582 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1220533004583 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1220533004584 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1220533004585 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1220533004586 putative active site [active] 1220533004587 PhoH-like protein; Region: PhoH; pfam02562 1220533004588 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1220533004589 glutaminase A; Region: Gln_ase; TIGR03814 1220533004590 hypothetical protein; Provisional; Region: PRK13666 1220533004591 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1220533004592 pyruvate carboxylase; Reviewed; Region: PRK12999 1220533004593 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1220533004594 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1220533004595 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1220533004596 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1220533004597 active site 1220533004598 catalytic residues [active] 1220533004599 metal binding site [ion binding]; metal-binding site 1220533004600 homodimer binding site [polypeptide binding]; other site 1220533004601 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1220533004602 carboxyltransferase (CT) interaction site; other site 1220533004603 biotinylation site [posttranslational modification]; other site 1220533004604 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1220533004605 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1220533004606 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1220533004607 UbiA prenyltransferase family; Region: UbiA; pfam01040 1220533004608 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1220533004609 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1220533004610 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 1220533004611 Cytochrome c; Region: Cytochrom_C; pfam00034 1220533004612 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1220533004613 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1220533004614 D-pathway; other site 1220533004615 Putative ubiquinol binding site [chemical binding]; other site 1220533004616 Low-spin heme (heme b) binding site [chemical binding]; other site 1220533004617 Putative water exit pathway; other site 1220533004618 Binuclear center (heme o3/CuB) [ion binding]; other site 1220533004619 K-pathway; other site 1220533004620 Putative proton exit pathway; other site 1220533004621 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1220533004622 Subunit I/III interface [polypeptide binding]; other site 1220533004623 Subunit III/IV interface [polypeptide binding]; other site 1220533004624 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1220533004625 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1220533004626 YugN-like family; Region: YugN; pfam08868 1220533004627 FOG: CBS domain [General function prediction only]; Region: COG0517 1220533004628 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1220533004629 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1220533004630 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1220533004631 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1220533004632 Putative coat protein; Region: YlbD_coat; pfam14071 1220533004633 YlbE-like protein; Region: YlbE; pfam14003 1220533004634 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1220533004635 hypothetical protein; Provisional; Region: PRK02886 1220533004636 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1220533004637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533004638 S-adenosylmethionine binding site [chemical binding]; other site 1220533004639 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1220533004640 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1220533004641 active site 1220533004642 (T/H)XGH motif; other site 1220533004643 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1220533004644 Nucleoside recognition; Region: Gate; pfam07670 1220533004645 Nucleoside recognition; Region: Gate; pfam07670 1220533004646 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1220533004647 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1220533004648 nucleophile elbow; other site 1220533004649 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1220533004650 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1220533004651 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1220533004652 protein binding site [polypeptide binding]; other site 1220533004653 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1220533004654 hypothetical protein; Provisional; Region: PRK13670 1220533004655 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1220533004656 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1220533004657 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1220533004658 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1220533004659 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1220533004660 hypothetical protein; Provisional; Region: PRK13688 1220533004661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533004662 Coenzyme A binding pocket [chemical binding]; other site 1220533004663 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1220533004664 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1220533004665 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1220533004666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1220533004667 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1220533004668 mraZ protein; Region: TIGR00242 1220533004669 MraZ protein; Region: MraZ; pfam02381 1220533004670 MraZ protein; Region: MraZ; pfam02381 1220533004671 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1220533004672 MraW methylase family; Region: Methyltransf_5; pfam01795 1220533004673 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1220533004674 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1220533004675 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1220533004676 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1220533004677 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1220533004678 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1220533004679 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1220533004680 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1220533004681 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1220533004682 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1220533004683 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1220533004684 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1220533004685 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1220533004686 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1220533004687 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1220533004688 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1220533004689 Mg++ binding site [ion binding]; other site 1220533004690 putative catalytic motif [active] 1220533004691 putative substrate binding site [chemical binding]; other site 1220533004692 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1220533004693 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1220533004694 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1220533004695 stage V sporulation protein E; Region: spoVE; TIGR02615 1220533004696 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1220533004697 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1220533004698 active site 1220533004699 homodimer interface [polypeptide binding]; other site 1220533004700 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1220533004701 FAD binding domain; Region: FAD_binding_4; pfam01565 1220533004702 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1220533004703 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1220533004704 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1220533004705 Cell division protein FtsQ; Region: FtsQ; pfam03799 1220533004706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1220533004707 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1220533004708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1220533004709 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1220533004710 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1220533004711 cell division protein FtsA; Region: ftsA; TIGR01174 1220533004712 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1220533004713 nucleotide binding site [chemical binding]; other site 1220533004714 Cell division protein FtsA; Region: FtsA; pfam14450 1220533004715 cell division protein FtsZ; Validated; Region: PRK09330 1220533004716 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1220533004717 nucleotide binding site [chemical binding]; other site 1220533004718 SulA interaction site; other site 1220533004719 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1220533004720 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1220533004721 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1220533004722 active site 1220533004723 catalytic triad [active] 1220533004724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1220533004725 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1220533004726 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1220533004727 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1220533004728 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1220533004729 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1220533004730 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1220533004731 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533004732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533004733 DNA binding residues [nucleotide binding] 1220533004734 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1220533004735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533004736 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1220533004737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533004738 DNA binding residues [nucleotide binding] 1220533004739 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1220533004740 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1220533004741 Walker A/P-loop; other site 1220533004742 ATP binding site [chemical binding]; other site 1220533004743 Q-loop/lid; other site 1220533004744 ABC transporter signature motif; other site 1220533004745 Walker B; other site 1220533004746 D-loop; other site 1220533004747 H-loop/switch region; other site 1220533004748 acetylornithine deacetylase; Validated; Region: PRK08596 1220533004749 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1220533004750 metal binding site [ion binding]; metal-binding site 1220533004751 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1220533004752 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1220533004753 uncharacterized protein, YfiH family; Region: TIGR00726 1220533004754 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1220533004755 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1220533004756 catalytic residue [active] 1220533004757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1220533004758 YGGT family; Region: YGGT; pfam02325 1220533004759 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1220533004760 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533004761 RNA binding surface [nucleotide binding]; other site 1220533004762 DivIVA protein; Region: DivIVA; pfam05103 1220533004763 DivIVA domain; Region: DivI1A_domain; TIGR03544 1220533004764 T-box; B657_miscRNA25 1220533004765 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1220533004766 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1220533004767 HIGH motif; other site 1220533004768 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1220533004769 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1220533004770 active site 1220533004771 KMSKS motif; other site 1220533004772 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1220533004773 tRNA binding surface [nucleotide binding]; other site 1220533004774 anticodon binding site; other site 1220533004775 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1220533004776 lipoprotein signal peptidase; Region: lspA; TIGR00077 1220533004777 lipoprotein signal peptidase; Provisional; Region: PRK14787 1220533004778 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1220533004779 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533004780 RNA binding surface [nucleotide binding]; other site 1220533004781 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1220533004782 active site 1220533004783 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1220533004784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533004785 active site 1220533004786 uracil-xanthine permease; Region: ncs2; TIGR00801 1220533004787 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1220533004788 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1220533004789 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1220533004790 dihydroorotase; Validated; Region: pyrC; PRK09357 1220533004791 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1220533004792 active site 1220533004793 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1220533004794 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1220533004795 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1220533004796 catalytic site [active] 1220533004797 subunit interface [polypeptide binding]; other site 1220533004798 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1220533004799 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1220533004800 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1220533004801 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1220533004802 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1220533004803 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1220533004804 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1220533004805 IMP binding site; other site 1220533004806 dimer interface [polypeptide binding]; other site 1220533004807 interdomain contacts; other site 1220533004808 partial ornithine binding site; other site 1220533004809 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1220533004810 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1220533004811 FAD binding pocket [chemical binding]; other site 1220533004812 FAD binding motif [chemical binding]; other site 1220533004813 phosphate binding motif [ion binding]; other site 1220533004814 beta-alpha-beta structure motif; other site 1220533004815 NAD binding pocket [chemical binding]; other site 1220533004816 Iron coordination center [ion binding]; other site 1220533004817 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1220533004818 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1220533004819 heterodimer interface [polypeptide binding]; other site 1220533004820 active site 1220533004821 FMN binding site [chemical binding]; other site 1220533004822 homodimer interface [polypeptide binding]; other site 1220533004823 substrate binding site [chemical binding]; other site 1220533004824 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1220533004825 active site 1220533004826 dimer interface [polypeptide binding]; other site 1220533004827 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533004828 active site 1220533004829 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1220533004830 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1220533004831 Active Sites [active] 1220533004832 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1220533004833 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1220533004834 ATP-sulfurylase; Region: ATPS; cd00517 1220533004835 active site 1220533004836 HXXH motif; other site 1220533004837 flexible loop; other site 1220533004838 AAA domain; Region: AAA_33; pfam13671 1220533004839 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1220533004840 ligand-binding site [chemical binding]; other site 1220533004841 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1220533004842 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1220533004843 active site 1220533004844 SAM binding site [chemical binding]; other site 1220533004845 homodimer interface [polypeptide binding]; other site 1220533004846 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1220533004847 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1220533004848 putative active site [active] 1220533004849 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1220533004850 putative active site [active] 1220533004851 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1220533004852 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1220533004853 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1220533004854 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1220533004855 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1220533004856 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1220533004857 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1220533004858 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1220533004859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533004860 motif II; other site 1220533004861 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1220533004862 TIGR00255 family protein; Region: TIGR00255 1220533004863 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1220533004864 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1220533004865 hypothetical protein; Provisional; Region: PRK04323 1220533004866 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1220533004867 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1220533004868 catalytic site [active] 1220533004869 G-X2-G-X-G-K; other site 1220533004870 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1220533004871 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1220533004872 Flavoprotein; Region: Flavoprotein; pfam02441 1220533004873 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1220533004874 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1220533004875 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533004876 ATP binding site [chemical binding]; other site 1220533004877 putative Mg++ binding site [ion binding]; other site 1220533004878 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533004879 nucleotide binding region [chemical binding]; other site 1220533004880 ATP-binding site [chemical binding]; other site 1220533004881 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1220533004882 active site 1220533004883 catalytic residues [active] 1220533004884 metal binding site [ion binding]; metal-binding site 1220533004885 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1220533004886 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1220533004887 putative active site [active] 1220533004888 substrate binding site [chemical binding]; other site 1220533004889 putative cosubstrate binding site; other site 1220533004890 catalytic site [active] 1220533004891 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1220533004892 substrate binding site [chemical binding]; other site 1220533004893 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1220533004894 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1220533004895 putative RNA binding site [nucleotide binding]; other site 1220533004896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533004897 S-adenosylmethionine binding site [chemical binding]; other site 1220533004898 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1220533004899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533004900 FeS/SAM binding site; other site 1220533004901 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1220533004902 Protein phosphatase 2C; Region: PP2C; pfam00481 1220533004903 active site 1220533004904 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1220533004905 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1220533004906 active site 1220533004907 ATP binding site [chemical binding]; other site 1220533004908 substrate binding site [chemical binding]; other site 1220533004909 activation loop (A-loop); other site 1220533004910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1220533004911 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1220533004912 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1220533004913 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1220533004914 GTPase RsgA; Reviewed; Region: PRK00098 1220533004915 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1220533004916 RNA binding site [nucleotide binding]; other site 1220533004917 homodimer interface [polypeptide binding]; other site 1220533004918 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1220533004919 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1220533004920 GTP/Mg2+ binding site [chemical binding]; other site 1220533004921 G4 box; other site 1220533004922 G5 box; other site 1220533004923 G1 box; other site 1220533004924 Switch I region; other site 1220533004925 G2 box; other site 1220533004926 G3 box; other site 1220533004927 Switch II region; other site 1220533004928 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1220533004929 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1220533004930 substrate binding site [chemical binding]; other site 1220533004931 hexamer interface [polypeptide binding]; other site 1220533004932 metal binding site [ion binding]; metal-binding site 1220533004933 Thiamine pyrophosphokinase; Region: TPK; cd07995 1220533004934 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1220533004935 active site 1220533004936 dimerization interface [polypeptide binding]; other site 1220533004937 thiamine binding site [chemical binding]; other site 1220533004938 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1220533004939 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1220533004940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1220533004941 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1220533004942 DAK2 domain; Region: Dak2; pfam02734 1220533004943 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1220533004944 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1220533004945 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1220533004946 putative L-serine binding site [chemical binding]; other site 1220533004947 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 1220533004948 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1220533004949 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1220533004950 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1220533004951 generic binding surface II; other site 1220533004952 ssDNA binding site; other site 1220533004953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533004954 ATP binding site [chemical binding]; other site 1220533004955 putative Mg++ binding site [ion binding]; other site 1220533004956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533004957 nucleotide binding region [chemical binding]; other site 1220533004958 ATP-binding site [chemical binding]; other site 1220533004959 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1220533004960 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1220533004961 putative phosphate acyltransferase; Provisional; Region: PRK05331 1220533004962 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1220533004963 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1220533004964 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1220533004965 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1220533004966 NAD(P) binding site [chemical binding]; other site 1220533004967 homotetramer interface [polypeptide binding]; other site 1220533004968 homodimer interface [polypeptide binding]; other site 1220533004969 active site 1220533004970 acyl carrier protein; Provisional; Region: acpP; PRK00982 1220533004971 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1220533004972 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1220533004973 dimerization interface [polypeptide binding]; other site 1220533004974 active site 1220533004975 metal binding site [ion binding]; metal-binding site 1220533004976 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1220533004977 dsRNA binding site [nucleotide binding]; other site 1220533004978 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1220533004979 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1220533004980 Walker A/P-loop; other site 1220533004981 ATP binding site [chemical binding]; other site 1220533004982 Q-loop/lid; other site 1220533004983 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1220533004984 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1220533004985 ABC transporter signature motif; other site 1220533004986 Walker B; other site 1220533004987 D-loop; other site 1220533004988 H-loop/switch region; other site 1220533004989 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1220533004990 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1220533004991 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1220533004992 GTP binding site [chemical binding]; other site 1220533004993 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1220533004994 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1220533004995 putative DNA-binding protein; Validated; Region: PRK00118 1220533004996 signal recognition particle protein; Provisional; Region: PRK10867 1220533004997 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1220533004998 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1220533004999 P loop; other site 1220533005000 GTP binding site [chemical binding]; other site 1220533005001 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1220533005002 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1220533005003 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1220533005004 KH domain; Region: KH_4; pfam13083 1220533005005 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1220533005006 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1220533005007 RimM N-terminal domain; Region: RimM; pfam01782 1220533005008 PRC-barrel domain; Region: PRC; pfam05239 1220533005009 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1220533005010 L19_leader; B657_miscRNA30 1220533005011 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1220533005012 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1220533005013 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1220533005014 GTP/Mg2+ binding site [chemical binding]; other site 1220533005015 G4 box; other site 1220533005016 G5 box; other site 1220533005017 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1220533005018 G1 box; other site 1220533005019 G1 box; other site 1220533005020 GTP/Mg2+ binding site [chemical binding]; other site 1220533005021 Switch I region; other site 1220533005022 G2 box; other site 1220533005023 G2 box; other site 1220533005024 G3 box; other site 1220533005025 G3 box; other site 1220533005026 Switch II region; other site 1220533005027 Switch II region; other site 1220533005028 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1220533005029 RNA/DNA hybrid binding site [nucleotide binding]; other site 1220533005030 active site 1220533005031 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1220533005032 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1220533005033 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1220533005034 CoA-ligase; Region: Ligase_CoA; pfam00549 1220533005035 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1220533005036 CoA binding domain; Region: CoA_binding; smart00881 1220533005037 CoA-ligase; Region: Ligase_CoA; pfam00549 1220533005038 DNA protecting protein DprA; Region: dprA; TIGR00732 1220533005039 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1220533005040 DNA topoisomerase I; Validated; Region: PRK05582 1220533005041 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1220533005042 active site 1220533005043 interdomain interaction site; other site 1220533005044 putative metal-binding site [ion binding]; other site 1220533005045 nucleotide binding site [chemical binding]; other site 1220533005046 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1220533005047 domain I; other site 1220533005048 DNA binding groove [nucleotide binding] 1220533005049 phosphate binding site [ion binding]; other site 1220533005050 domain II; other site 1220533005051 domain III; other site 1220533005052 nucleotide binding site [chemical binding]; other site 1220533005053 catalytic site [active] 1220533005054 domain IV; other site 1220533005055 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1220533005056 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1220533005057 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1220533005058 Glucose inhibited division protein A; Region: GIDA; pfam01134 1220533005059 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1220533005060 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1220533005061 active site 1220533005062 Int/Topo IB signature motif; other site 1220533005063 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1220533005064 active site 1220533005065 HslU subunit interaction site [polypeptide binding]; other site 1220533005066 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1220533005067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533005068 Walker A motif; other site 1220533005069 ATP binding site [chemical binding]; other site 1220533005070 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1220533005071 Walker B motif; other site 1220533005072 arginine finger; other site 1220533005073 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1220533005074 transcriptional repressor CodY; Validated; Region: PRK04158 1220533005075 CodY GAF-like domain; Region: CodY; pfam06018 1220533005076 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1220533005077 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1220533005078 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1220533005079 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1220533005080 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1220533005081 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1220533005082 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1220533005083 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1220533005084 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1220533005085 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1220533005086 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1220533005087 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1220533005088 MgtE intracellular N domain; Region: MgtE_N; smart00924 1220533005089 FliG C-terminal domain; Region: FliG_C; pfam01706 1220533005090 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 1220533005091 Flagellar assembly protein FliH; Region: FliH; pfam02108 1220533005092 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1220533005093 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1220533005094 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1220533005095 Walker A motif/ATP binding site; other site 1220533005096 Walker B motif; other site 1220533005097 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1220533005098 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1220533005099 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1220533005100 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1220533005101 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1220533005102 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1220533005103 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1220533005104 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1220533005105 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1220533005106 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1220533005107 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 1220533005108 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1220533005109 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1220533005110 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1220533005111 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1220533005112 flagellar motor switch protein; Validated; Region: PRK08119 1220533005113 CheC-like family; Region: CheC; pfam04509 1220533005114 CheC-like family; Region: CheC; pfam04509 1220533005115 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1220533005116 Response regulator receiver domain; Region: Response_reg; pfam00072 1220533005117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533005118 active site 1220533005119 phosphorylation site [posttranslational modification] 1220533005120 intermolecular recognition site; other site 1220533005121 dimerization interface [polypeptide binding]; other site 1220533005122 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1220533005123 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1220533005124 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1220533005125 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1220533005126 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1220533005127 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1220533005128 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1220533005129 FHIPEP family; Region: FHIPEP; pfam00771 1220533005130 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1220533005131 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1220533005132 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1220533005133 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1220533005134 P-loop; other site 1220533005135 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1220533005136 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1220533005137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533005138 active site 1220533005139 phosphorylation site [posttranslational modification] 1220533005140 intermolecular recognition site; other site 1220533005141 dimerization interface [polypeptide binding]; other site 1220533005142 CheB methylesterase; Region: CheB_methylest; pfam01339 1220533005143 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1220533005144 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1220533005145 putative binding surface; other site 1220533005146 active site 1220533005147 P2 response regulator binding domain; Region: P2; pfam07194 1220533005148 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1220533005149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533005150 ATP binding site [chemical binding]; other site 1220533005151 Mg2+ binding site [ion binding]; other site 1220533005152 G-X-G motif; other site 1220533005153 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1220533005154 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1220533005155 putative CheA interaction surface; other site 1220533005156 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1220533005157 CheC-like family; Region: CheC; pfam04509 1220533005158 CheC-like family; Region: CheC; pfam04509 1220533005159 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1220533005160 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1220533005161 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533005162 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1220533005163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533005164 DNA binding residues [nucleotide binding] 1220533005165 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1220533005166 rRNA interaction site [nucleotide binding]; other site 1220533005167 S8 interaction site; other site 1220533005168 putative laminin-1 binding site; other site 1220533005169 elongation factor Ts; Provisional; Region: tsf; PRK09377 1220533005170 UBA/TS-N domain; Region: UBA; pfam00627 1220533005171 Elongation factor TS; Region: EF_TS; pfam00889 1220533005172 Elongation factor TS; Region: EF_TS; pfam00889 1220533005173 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1220533005174 putative nucleotide binding site [chemical binding]; other site 1220533005175 uridine monophosphate binding site [chemical binding]; other site 1220533005176 homohexameric interface [polypeptide binding]; other site 1220533005177 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1220533005178 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1220533005179 hinge region; other site 1220533005180 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1220533005181 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1220533005182 catalytic residue [active] 1220533005183 putative FPP diphosphate binding site; other site 1220533005184 putative FPP binding hydrophobic cleft; other site 1220533005185 dimer interface [polypeptide binding]; other site 1220533005186 putative IPP diphosphate binding site; other site 1220533005187 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1220533005188 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1220533005189 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1220533005190 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1220533005191 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1220533005192 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1220533005193 RIP metalloprotease RseP; Region: TIGR00054 1220533005194 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1220533005195 active site 1220533005196 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1220533005197 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1220533005198 protein binding site [polypeptide binding]; other site 1220533005199 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1220533005200 putative substrate binding region [chemical binding]; other site 1220533005201 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1220533005202 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1220533005203 dimer interface [polypeptide binding]; other site 1220533005204 motif 1; other site 1220533005205 active site 1220533005206 motif 2; other site 1220533005207 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1220533005208 putative deacylase active site [active] 1220533005209 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1220533005210 active site 1220533005211 motif 3; other site 1220533005212 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1220533005213 anticodon binding site; other site 1220533005214 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1220533005215 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1220533005216 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1220533005217 generic binding surface II; other site 1220533005218 generic binding surface I; other site 1220533005219 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1220533005220 active site 1220533005221 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1220533005222 active site 1220533005223 catalytic site [active] 1220533005224 substrate binding site [chemical binding]; other site 1220533005225 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1220533005226 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1220533005227 Sm and related proteins; Region: Sm_like; cl00259 1220533005228 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1220533005229 putative oligomer interface [polypeptide binding]; other site 1220533005230 putative RNA binding site [nucleotide binding]; other site 1220533005231 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1220533005232 NusA N-terminal domain; Region: NusA_N; pfam08529 1220533005233 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1220533005234 RNA binding site [nucleotide binding]; other site 1220533005235 homodimer interface [polypeptide binding]; other site 1220533005236 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1220533005237 G-X-X-G motif; other site 1220533005238 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1220533005239 G-X-X-G motif; other site 1220533005240 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1220533005241 putative RNA binding cleft [nucleotide binding]; other site 1220533005242 hypothetical protein; Provisional; Region: PRK07714 1220533005243 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1220533005244 translation initiation factor IF-2; Region: IF-2; TIGR00487 1220533005245 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1220533005246 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1220533005247 G1 box; other site 1220533005248 putative GEF interaction site [polypeptide binding]; other site 1220533005249 GTP/Mg2+ binding site [chemical binding]; other site 1220533005250 Switch I region; other site 1220533005251 G2 box; other site 1220533005252 G3 box; other site 1220533005253 Switch II region; other site 1220533005254 G4 box; other site 1220533005255 G5 box; other site 1220533005256 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1220533005257 Translation-initiation factor 2; Region: IF-2; pfam11987 1220533005258 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1220533005259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1220533005260 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1220533005261 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1220533005262 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1220533005263 RNA binding site [nucleotide binding]; other site 1220533005264 active site 1220533005265 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1220533005266 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1220533005267 active site 1220533005268 Riboflavin kinase; Region: Flavokinase; smart00904 1220533005269 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1220533005270 16S/18S rRNA binding site [nucleotide binding]; other site 1220533005271 S13e-L30e interaction site [polypeptide binding]; other site 1220533005272 25S rRNA binding site [nucleotide binding]; other site 1220533005273 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1220533005274 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1220533005275 RNase E interface [polypeptide binding]; other site 1220533005276 trimer interface [polypeptide binding]; other site 1220533005277 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1220533005278 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1220533005279 RNase E interface [polypeptide binding]; other site 1220533005280 trimer interface [polypeptide binding]; other site 1220533005281 active site 1220533005282 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1220533005283 putative nucleic acid binding region [nucleotide binding]; other site 1220533005284 G-X-X-G motif; other site 1220533005285 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1220533005286 RNA binding site [nucleotide binding]; other site 1220533005287 domain interface; other site 1220533005288 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1220533005289 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1220533005290 NodB motif; other site 1220533005291 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1220533005292 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1220533005293 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1220533005294 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1220533005295 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1220533005296 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1220533005297 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1220533005298 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1220533005299 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1220533005300 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1220533005301 aspartate kinase I; Reviewed; Region: PRK08210 1220533005302 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1220533005303 putative catalytic residues [active] 1220533005304 putative nucleotide binding site [chemical binding]; other site 1220533005305 putative aspartate binding site [chemical binding]; other site 1220533005306 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1220533005307 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1220533005308 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1220533005309 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1220533005310 dimer interface [polypeptide binding]; other site 1220533005311 active site 1220533005312 catalytic residue [active] 1220533005313 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1220533005314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1220533005315 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1220533005316 Clp protease; Region: CLP_protease; pfam00574 1220533005317 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1220533005318 active site 1220533005319 YlzJ-like protein; Region: YlzJ; pfam14035 1220533005320 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1220533005321 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1220533005322 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1220533005323 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1220533005324 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1220533005325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533005326 DNA-binding site [nucleotide binding]; DNA binding site 1220533005327 UTRA domain; Region: UTRA; pfam07702 1220533005328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533005329 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533005330 putative substrate translocation pore; other site 1220533005331 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1220533005332 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1220533005333 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1220533005334 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1220533005335 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1220533005336 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1220533005337 classical (c) SDRs; Region: SDR_c; cd05233 1220533005338 NAD(P) binding site [chemical binding]; other site 1220533005339 active site 1220533005340 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1220533005341 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1220533005342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533005343 non-specific DNA binding site [nucleotide binding]; other site 1220533005344 salt bridge; other site 1220533005345 sequence-specific DNA binding site [nucleotide binding]; other site 1220533005346 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1220533005347 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1220533005348 competence damage-inducible protein A; Provisional; Region: PRK00549 1220533005349 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1220533005350 putative MPT binding site; other site 1220533005351 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 1220533005352 recombinase A; Provisional; Region: recA; PRK09354 1220533005353 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1220533005354 hexamer interface [polypeptide binding]; other site 1220533005355 Walker A motif; other site 1220533005356 ATP binding site [chemical binding]; other site 1220533005357 Walker B motif; other site 1220533005358 Beta-lactamase; Region: Beta-lactamase; pfam00144 1220533005359 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1220533005360 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1220533005361 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1220533005362 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1220533005363 Zn2+ binding site [ion binding]; other site 1220533005364 Mg2+ binding site [ion binding]; other site 1220533005365 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1220533005366 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1220533005367 putative active site [active] 1220533005368 metal binding site [ion binding]; metal-binding site 1220533005369 homodimer binding site [polypeptide binding]; other site 1220533005370 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1220533005371 Threonine dehydrogenase; Region: TDH; cd05281 1220533005372 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 1220533005373 structural Zn binding site [ion binding]; other site 1220533005374 catalytic Zn binding site [ion binding]; other site 1220533005375 tetramer interface [polypeptide binding]; other site 1220533005376 NADP binding site [chemical binding]; other site 1220533005377 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1220533005378 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1220533005379 substrate-cofactor binding pocket; other site 1220533005380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533005381 catalytic residue [active] 1220533005382 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1220533005383 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1220533005384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533005385 FeS/SAM binding site; other site 1220533005386 TRAM domain; Region: TRAM; pfam01938 1220533005387 Predicted membrane protein [Function unknown]; Region: COG4550 1220533005388 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1220533005389 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1220533005390 MutS domain I; Region: MutS_I; pfam01624 1220533005391 MutS domain II; Region: MutS_II; pfam05188 1220533005392 MutS domain III; Region: MutS_III; pfam05192 1220533005393 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1220533005394 Walker A/P-loop; other site 1220533005395 ATP binding site [chemical binding]; other site 1220533005396 Q-loop/lid; other site 1220533005397 ABC transporter signature motif; other site 1220533005398 Walker B; other site 1220533005399 D-loop; other site 1220533005400 H-loop/switch region; other site 1220533005401 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1220533005402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533005403 ATP binding site [chemical binding]; other site 1220533005404 Mg2+ binding site [ion binding]; other site 1220533005405 G-X-G motif; other site 1220533005406 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1220533005407 ATP binding site [chemical binding]; other site 1220533005408 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1220533005409 Regulatory protein YrvL; Region: YrvL; pfam14184 1220533005410 transcriptional regulator BetI; Validated; Region: PRK00767 1220533005411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533005412 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1220533005413 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1220533005414 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1220533005415 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1220533005416 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1220533005417 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1220533005418 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1220533005419 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1220533005420 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1220533005421 FMN binding site [chemical binding]; other site 1220533005422 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1220533005423 substrate binding site [chemical binding]; other site 1220533005424 putative catalytic residue [active] 1220533005425 acyl carrier protein; Validated; Region: PRK07117 1220533005426 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1220533005427 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1220533005428 dimer interface [polypeptide binding]; other site 1220533005429 active site 1220533005430 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1220533005431 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1220533005432 dimer interface [polypeptide binding]; other site 1220533005433 active site 1220533005434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1220533005435 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1220533005436 substrate binding site [chemical binding]; other site 1220533005437 oxyanion hole (OAH) forming residues; other site 1220533005438 trimer interface [polypeptide binding]; other site 1220533005439 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1220533005440 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1220533005441 substrate binding site [chemical binding]; other site 1220533005442 oxyanion hole (OAH) forming residues; other site 1220533005443 trimer interface [polypeptide binding]; other site 1220533005444 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1220533005445 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1220533005446 acyl-activating enzyme (AAE) consensus motif; other site 1220533005447 putative AMP binding site [chemical binding]; other site 1220533005448 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005449 Condensation domain; Region: Condensation; pfam00668 1220533005450 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005451 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533005452 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1220533005453 acyl-activating enzyme (AAE) consensus motif; other site 1220533005454 AMP binding site [chemical binding]; other site 1220533005455 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005456 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1220533005457 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005458 active site 1220533005459 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1220533005460 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1220533005461 KR domain; Region: KR; pfam08659 1220533005462 putative NADP binding site [chemical binding]; other site 1220533005463 active site 1220533005464 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005465 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005466 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1220533005467 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005468 active site 1220533005469 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1220533005470 putative NADP binding site [chemical binding]; other site 1220533005471 active site 1220533005472 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005473 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005474 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1220533005475 active site 1220533005476 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1220533005477 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005478 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1220533005479 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005480 active site 1220533005481 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1220533005482 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1220533005483 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1220533005484 putative NADP binding site [chemical binding]; other site 1220533005485 active site 1220533005486 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005487 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005488 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1220533005489 active site 1220533005490 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1220533005491 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1220533005492 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1220533005493 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005494 active site 1220533005495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1220533005496 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1220533005497 putative NADP binding site [chemical binding]; other site 1220533005498 active site 1220533005499 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005500 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005501 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1220533005502 active site 1220533005503 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1220533005504 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1220533005505 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1220533005506 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005507 active site 1220533005508 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1220533005509 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1220533005510 putative NADP binding site [chemical binding]; other site 1220533005511 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1220533005512 active site 1220533005513 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1220533005514 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005515 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1220533005516 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005517 active site 1220533005518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1220533005519 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1220533005520 putative NADP binding site [chemical binding]; other site 1220533005521 active site 1220533005522 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005523 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005524 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1220533005525 active site 1220533005526 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005527 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1220533005528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533005529 S-adenosylmethionine binding site [chemical binding]; other site 1220533005530 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1220533005531 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005532 active site 1220533005533 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1220533005534 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1220533005535 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1220533005536 active site 1220533005537 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1220533005538 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1220533005539 Cytochrome P450; Region: p450; cl12078 1220533005540 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1220533005541 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1220533005542 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1220533005543 active site 1220533005544 catalytic triad [active] 1220533005545 Phage-related replication protein [General function prediction only]; Region: COG4195 1220533005546 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1220533005547 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1220533005548 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1220533005549 YmaF family; Region: YmaF; pfam12788 1220533005550 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1220533005551 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1220533005552 bacterial Hfq-like; Region: Hfq; cd01716 1220533005553 hexamer interface [polypeptide binding]; other site 1220533005554 Sm1 motif; other site 1220533005555 RNA binding site [nucleotide binding]; other site 1220533005556 Sm2 motif; other site 1220533005557 YmzC-like protein; Region: YmzC; pfam14157 1220533005558 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1220533005559 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1220533005560 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1220533005561 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1220533005562 active site 1220533005563 dimer interface [polypeptide binding]; other site 1220533005564 catalytic residues [active] 1220533005565 effector binding site; other site 1220533005566 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1220533005567 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1220533005568 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1220533005569 dimer interface [polypeptide binding]; other site 1220533005570 putative radical transfer pathway; other site 1220533005571 diiron center [ion binding]; other site 1220533005572 tyrosyl radical; other site 1220533005573 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1220533005574 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1220533005575 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1220533005576 active site 1220533005577 metal binding site [ion binding]; metal-binding site 1220533005578 Sporulation related domain; Region: SPOR; pfam05036 1220533005579 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1220533005580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533005581 Walker A motif; other site 1220533005582 ATP binding site [chemical binding]; other site 1220533005583 Walker B motif; other site 1220533005584 arginine finger; other site 1220533005585 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1220533005586 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1220533005587 HflX GTPase family; Region: HflX; cd01878 1220533005588 G1 box; other site 1220533005589 GTP/Mg2+ binding site [chemical binding]; other site 1220533005590 Switch I region; other site 1220533005591 G2 box; other site 1220533005592 G3 box; other site 1220533005593 Switch II region; other site 1220533005594 G4 box; other site 1220533005595 G5 box; other site 1220533005596 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1220533005597 Aluminium resistance protein; Region: Alum_res; pfam06838 1220533005598 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1220533005599 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1220533005600 DNA binding residues [nucleotide binding] 1220533005601 putative dimer interface [polypeptide binding]; other site 1220533005602 glutamine synthetase, type I; Region: GlnA; TIGR00653 1220533005603 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1220533005604 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1220533005605 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1220533005606 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1220533005607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533005608 Coenzyme A binding pocket [chemical binding]; other site 1220533005609 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1220533005610 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1220533005611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533005612 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1220533005613 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1220533005614 inhibitor binding site; inhibition site 1220533005615 active site 1220533005616 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1220533005617 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1220533005618 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1220533005619 nucleotide binding site [chemical binding]; other site 1220533005620 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1220533005621 xylose isomerase; Provisional; Region: PRK05474 1220533005622 xylose isomerase; Region: xylose_isom_A; TIGR02630 1220533005623 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1220533005624 N- and C-terminal domain interface [polypeptide binding]; other site 1220533005625 D-xylulose kinase; Region: XylB; TIGR01312 1220533005626 active site 1220533005627 MgATP binding site [chemical binding]; other site 1220533005628 catalytic site [active] 1220533005629 metal binding site [ion binding]; metal-binding site 1220533005630 xylulose binding site [chemical binding]; other site 1220533005631 homodimer interface [polypeptide binding]; other site 1220533005632 Staphylococcal nuclease homologues; Region: SNc; smart00318 1220533005633 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1220533005634 Catalytic site; other site 1220533005635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533005636 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1220533005637 putative substrate translocation pore; other site 1220533005638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533005639 alanine racemase; Region: alr; TIGR00492 1220533005640 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1220533005641 active site 1220533005642 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1220533005643 dimer interface [polypeptide binding]; other site 1220533005644 substrate binding site [chemical binding]; other site 1220533005645 catalytic residues [active] 1220533005646 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1220533005647 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1220533005648 trimer interface [polypeptide binding]; other site 1220533005649 active site 1220533005650 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1220533005651 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1220533005652 dimerization interface [polypeptide binding]; other site 1220533005653 active site 1220533005654 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1220533005655 putative binding site; other site 1220533005656 putative dimer interface [polypeptide binding]; other site 1220533005657 YoqO-like protein; Region: YoqO; pfam14037 1220533005658 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1220533005659 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1220533005660 putative hydrophobic ligand binding site [chemical binding]; other site 1220533005661 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1220533005662 Spore germination protein; Region: Spore_permease; pfam03845 1220533005663 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1220533005664 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1220533005665 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1220533005666 YndJ-like protein; Region: YndJ; pfam14158 1220533005667 Phage-related replication protein [General function prediction only]; Region: COG4195 1220533005668 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1220533005669 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1220533005670 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1220533005671 putative active site [active] 1220533005672 putative Mg binding site [ion binding]; other site 1220533005673 LexA repressor; Validated; Region: PRK00215 1220533005674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533005675 putative DNA binding site [nucleotide binding]; other site 1220533005676 putative Zn2+ binding site [ion binding]; other site 1220533005677 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1220533005678 Catalytic site [active] 1220533005679 cell division suppressor protein YneA; Provisional; Region: PRK14125 1220533005680 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533005681 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1220533005682 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1220533005683 catalytic residues [active] 1220533005684 catalytic nucleophile [active] 1220533005685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1220533005686 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1220533005687 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1220533005688 TPP-binding site [chemical binding]; other site 1220533005689 dimer interface [polypeptide binding]; other site 1220533005690 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1220533005691 PYR/PP interface [polypeptide binding]; other site 1220533005692 dimer interface [polypeptide binding]; other site 1220533005693 TPP binding site [chemical binding]; other site 1220533005694 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1220533005695 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1220533005696 hypothetical protein; Provisional; Region: PRK01844 1220533005697 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1220533005698 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1220533005699 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1220533005700 Response regulator receiver domain; Region: Response_reg; pfam00072 1220533005701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533005702 active site 1220533005703 phosphorylation site [posttranslational modification] 1220533005704 intermolecular recognition site; other site 1220533005705 dimerization interface [polypeptide binding]; other site 1220533005706 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1220533005707 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1220533005708 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1220533005709 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1220533005710 putative dimer interface [polypeptide binding]; other site 1220533005711 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1220533005712 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1220533005713 aconitate hydratase; Validated; Region: PRK09277 1220533005714 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1220533005715 substrate binding site [chemical binding]; other site 1220533005716 ligand binding site [chemical binding]; other site 1220533005717 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1220533005718 substrate binding site [chemical binding]; other site 1220533005719 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1220533005720 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1220533005721 catalytic residues [active] 1220533005722 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1220533005723 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1220533005724 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1220533005725 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1220533005726 active site 1220533005727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1220533005728 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1220533005729 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1220533005730 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1220533005731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533005732 ATP binding site [chemical binding]; other site 1220533005733 Mg2+ binding site [ion binding]; other site 1220533005734 G-X-G motif; other site 1220533005735 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1220533005736 anchoring element; other site 1220533005737 dimer interface [polypeptide binding]; other site 1220533005738 ATP binding site [chemical binding]; other site 1220533005739 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1220533005740 active site 1220533005741 putative metal-binding site [ion binding]; other site 1220533005742 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1220533005743 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1220533005744 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1220533005745 CAP-like domain; other site 1220533005746 active site 1220533005747 primary dimer interface [polypeptide binding]; other site 1220533005748 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533005749 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533005750 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533005751 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1220533005752 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1220533005753 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1220533005754 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1220533005755 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1220533005756 Cellulose binding domain; Region: CBM_3; pfam00942 1220533005757 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1220533005758 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1220533005759 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1220533005760 substrate binding site [chemical binding]; other site 1220533005761 active site 1220533005762 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1220533005763 metal binding site [ion binding]; metal-binding site 1220533005764 ligand binding site [chemical binding]; other site 1220533005765 Predicted membrane protein [Function unknown]; Region: COG2246 1220533005766 GtrA-like protein; Region: GtrA; pfam04138 1220533005767 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1220533005768 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1220533005769 active site 1220533005770 tetramer interface; other site 1220533005771 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1220533005772 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1220533005773 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1220533005774 DHH family; Region: DHH; pfam01368 1220533005775 DHHA1 domain; Region: DHHA1; pfam02272 1220533005776 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1220533005777 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1220533005778 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1220533005779 enoyl-CoA hydratase; Provisional; Region: PRK07657 1220533005780 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1220533005781 substrate binding site [chemical binding]; other site 1220533005782 oxyanion hole (OAH) forming residues; other site 1220533005783 trimer interface [polypeptide binding]; other site 1220533005784 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1220533005785 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1220533005786 active site 1220533005787 catalytic residues [active] 1220533005788 metal binding site [ion binding]; metal-binding site 1220533005789 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1220533005790 carboxyltransferase (CT) interaction site; other site 1220533005791 biotinylation site [posttranslational modification]; other site 1220533005792 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1220533005793 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1220533005794 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1220533005795 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1220533005796 AMP-binding domain protein; Validated; Region: PRK08315 1220533005797 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1220533005798 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1220533005799 acyl-activating enzyme (AAE) consensus motif; other site 1220533005800 putative AMP binding site [chemical binding]; other site 1220533005801 putative active site [active] 1220533005802 putative CoA binding site [chemical binding]; other site 1220533005803 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1220533005804 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1220533005805 active site 1220533005806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1220533005807 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1220533005808 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1220533005809 Condensation domain; Region: Condensation; pfam00668 1220533005810 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005811 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1220533005812 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1220533005813 acyl-activating enzyme (AAE) consensus motif; other site 1220533005814 AMP binding site [chemical binding]; other site 1220533005815 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005816 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1220533005817 Condensation domain; Region: Condensation; pfam00668 1220533005818 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005819 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533005820 acyl-activating enzyme (AAE) consensus motif; other site 1220533005821 AMP binding site [chemical binding]; other site 1220533005822 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005823 Condensation domain; Region: Condensation; pfam00668 1220533005824 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005825 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533005826 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533005827 acyl-activating enzyme (AAE) consensus motif; other site 1220533005828 AMP binding site [chemical binding]; other site 1220533005829 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005830 Condensation domain; Region: Condensation; pfam00668 1220533005831 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005832 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533005833 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533005834 acyl-activating enzyme (AAE) consensus motif; other site 1220533005835 AMP binding site [chemical binding]; other site 1220533005836 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005837 Condensation domain; Region: Condensation; pfam00668 1220533005838 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1220533005839 Condensation domain; Region: Condensation; pfam00668 1220533005840 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005841 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533005842 acyl-activating enzyme (AAE) consensus motif; other site 1220533005843 AMP binding site [chemical binding]; other site 1220533005844 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005845 Condensation domain; Region: Condensation; pfam00668 1220533005846 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005847 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533005848 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1220533005849 acyl-activating enzyme (AAE) consensus motif; other site 1220533005850 AMP binding site [chemical binding]; other site 1220533005851 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005852 Condensation domain; Region: Condensation; pfam00668 1220533005853 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1220533005854 Condensation domain; Region: Condensation; pfam00668 1220533005855 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005856 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533005857 acyl-activating enzyme (AAE) consensus motif; other site 1220533005858 AMP binding site [chemical binding]; other site 1220533005859 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005860 Condensation domain; Region: Condensation; pfam00668 1220533005861 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005862 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533005863 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533005864 acyl-activating enzyme (AAE) consensus motif; other site 1220533005865 AMP binding site [chemical binding]; other site 1220533005866 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533005867 Condensation domain; Region: Condensation; pfam00668 1220533005868 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533005869 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1220533005870 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1220533005871 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1220533005872 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1220533005873 active site 1220533005874 catalytic residues [active] 1220533005875 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1220533005876 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1220533005877 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1220533005878 Int/Topo IB signature motif; other site 1220533005879 Helix-turn-helix domain; Region: HTH_17; cl17695 1220533005880 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1220533005881 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1220533005882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533005883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533005884 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1220533005885 putative dimerization interface [polypeptide binding]; other site 1220533005886 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1220533005887 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1220533005888 active site 1220533005889 dimer interface [polypeptide binding]; other site 1220533005890 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1220533005891 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1220533005892 active site 1220533005893 FMN binding site [chemical binding]; other site 1220533005894 substrate binding site [chemical binding]; other site 1220533005895 3Fe-4S cluster binding site [ion binding]; other site 1220533005896 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1220533005897 domain interface; other site 1220533005898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533005899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533005900 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1220533005901 putative dimerization interface [polypeptide binding]; other site 1220533005902 gamma-glutamyl kinase; Provisional; Region: PRK13402 1220533005903 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1220533005904 nucleotide binding site [chemical binding]; other site 1220533005905 homotetrameric interface [polypeptide binding]; other site 1220533005906 putative phosphate binding site [ion binding]; other site 1220533005907 putative allosteric binding site; other site 1220533005908 PUA domain; Region: PUA; pfam01472 1220533005909 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1220533005910 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1220533005911 Replication terminator protein; Region: RTP; pfam02334 1220533005912 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1220533005913 classical (c) SDRs; Region: SDR_c; cd05233 1220533005914 NAD(P) binding site [chemical binding]; other site 1220533005915 active site 1220533005916 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1220533005917 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1220533005918 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1220533005919 polyol permease family; Region: 2A0118; TIGR00897 1220533005920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533005921 putative substrate translocation pore; other site 1220533005922 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1220533005923 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1220533005924 putative N- and C-terminal domain interface [polypeptide binding]; other site 1220533005925 putative active site [active] 1220533005926 putative MgATP binding site [chemical binding]; other site 1220533005927 catalytic site [active] 1220533005928 metal binding site [ion binding]; metal-binding site 1220533005929 carbohydrate binding site [chemical binding]; other site 1220533005930 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1220533005931 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1220533005932 putative ligand binding site [chemical binding]; other site 1220533005933 putative NAD binding site [chemical binding]; other site 1220533005934 catalytic site [active] 1220533005935 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1220533005936 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1220533005937 putative [4Fe-4S] binding site [ion binding]; other site 1220533005938 putative molybdopterin cofactor binding site [chemical binding]; other site 1220533005939 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1220533005940 putative molybdopterin cofactor binding site; other site 1220533005941 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1220533005942 CHASE3 domain; Region: CHASE3; cl05000 1220533005943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533005944 dimerization interface [polypeptide binding]; other site 1220533005945 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1220533005946 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533005947 dimer interface [polypeptide binding]; other site 1220533005948 putative CheW interface [polypeptide binding]; other site 1220533005949 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1220533005950 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1220533005951 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1220533005952 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1220533005953 Predicted membrane protein [Function unknown]; Region: COG3619 1220533005954 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1220533005955 Amb_all domain; Region: Amb_all; smart00656 1220533005956 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1220533005957 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1220533005958 Cupin; Region: Cupin_1; smart00835 1220533005959 Cupin; Region: Cupin_1; smart00835 1220533005960 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1220533005961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533005962 Coenzyme A binding pocket [chemical binding]; other site 1220533005963 YoaP-like; Region: YoaP; pfam14268 1220533005964 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1220533005965 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1220533005966 VanW like protein; Region: VanW; pfam04294 1220533005967 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1220533005968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533005969 salt bridge; other site 1220533005970 non-specific DNA binding site [nucleotide binding]; other site 1220533005971 sequence-specific DNA binding site [nucleotide binding]; other site 1220533005972 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1220533005973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533005974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533005975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533005976 dimerization interface [polypeptide binding]; other site 1220533005977 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1220533005978 EamA-like transporter family; Region: EamA; pfam00892 1220533005979 EamA-like transporter family; Region: EamA; pfam00892 1220533005980 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1220533005981 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1220533005982 conserved cys residue [active] 1220533005983 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1220533005984 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1220533005985 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1220533005986 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1220533005987 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1220533005988 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1220533005989 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1220533005990 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1220533005991 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533005992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533005993 non-specific DNA binding site [nucleotide binding]; other site 1220533005994 salt bridge; other site 1220533005995 sequence-specific DNA binding site [nucleotide binding]; other site 1220533005996 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1220533005997 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1220533005998 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1220533005999 putative active site [active] 1220533006000 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533006001 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533006002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533006003 TPR motif; other site 1220533006004 binding surface 1220533006005 Y-family of DNA polymerases; Region: PolY; cl12025 1220533006006 DNA binding site [nucleotide binding] 1220533006007 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1220533006008 Y-family of DNA polymerases; Region: PolY; cl12025 1220533006009 active site 1220533006010 YolD-like protein; Region: YolD; pfam08863 1220533006011 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1220533006012 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1220533006013 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1220533006014 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1220533006015 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1220533006016 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1220533006017 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1220533006018 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1220533006019 dimer interface [polypeptide binding]; other site 1220533006020 putative tRNA-binding site [nucleotide binding]; other site 1220533006021 Cupin domain; Region: Cupin_2; pfam07883 1220533006022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533006023 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533006024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533006025 Coenzyme A binding pocket [chemical binding]; other site 1220533006026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533006027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533006028 WHG domain; Region: WHG; pfam13305 1220533006029 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1220533006030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1220533006031 Predicted transcriptional regulator [Transcription]; Region: COG2378 1220533006032 HTH domain; Region: HTH_11; pfam08279 1220533006033 WYL domain; Region: WYL; pfam13280 1220533006034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533006035 dimerization interface [polypeptide binding]; other site 1220533006036 putative DNA binding site [nucleotide binding]; other site 1220533006037 putative Zn2+ binding site [ion binding]; other site 1220533006038 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1220533006039 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1220533006040 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1220533006041 catalytic residue [active] 1220533006042 Predicted membrane protein [Function unknown]; Region: COG2322 1220533006043 Protein required for attachment to host cells; Region: Host_attach; cl02398 1220533006044 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1220533006045 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1220533006046 putative dimer interface [polypeptide binding]; other site 1220533006047 catalytic triad [active] 1220533006048 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1220533006049 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1220533006050 putative di-iron ligands [ion binding]; other site 1220533006051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1220533006052 Histidine kinase; Region: HisKA_3; pfam07730 1220533006053 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1220533006054 ATP binding site [chemical binding]; other site 1220533006055 Mg2+ binding site [ion binding]; other site 1220533006056 G-X-G motif; other site 1220533006057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533006058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533006059 active site 1220533006060 phosphorylation site [posttranslational modification] 1220533006061 intermolecular recognition site; other site 1220533006062 dimerization interface [polypeptide binding]; other site 1220533006063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533006064 DNA binding residues [nucleotide binding] 1220533006065 dimerization interface [polypeptide binding]; other site 1220533006066 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533006067 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533006068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1220533006069 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1220533006070 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533006071 ATP binding site [chemical binding]; other site 1220533006072 putative Mg++ binding site [ion binding]; other site 1220533006073 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533006074 nucleotide binding region [chemical binding]; other site 1220533006075 ATP-binding site [chemical binding]; other site 1220533006076 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1220533006077 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1220533006078 azoreductase; Provisional; Region: PRK13556 1220533006079 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1220533006080 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1220533006081 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1220533006082 putative dimer interface [polypeptide binding]; other site 1220533006083 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1220533006084 pentamer interface [polypeptide binding]; other site 1220533006085 dodecaamer interface [polypeptide binding]; other site 1220533006086 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1220533006087 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1220533006088 NAD(P) binding site [chemical binding]; other site 1220533006089 catalytic residues [active] 1220533006090 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1220533006091 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1220533006092 Active site cavity [active] 1220533006093 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1220533006094 catalytic acid [active] 1220533006095 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1220533006096 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1220533006097 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1220533006098 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1220533006099 Na2 binding site [ion binding]; other site 1220533006100 putative substrate binding site 1 [chemical binding]; other site 1220533006101 Na binding site 1 [ion binding]; other site 1220533006102 putative substrate binding site 2 [chemical binding]; other site 1220533006103 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1220533006104 Sodium Bile acid symporter family; Region: SBF; pfam01758 1220533006105 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1220533006106 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1220533006107 E3 interaction surface; other site 1220533006108 lipoyl attachment site [posttranslational modification]; other site 1220533006109 e3 binding domain; Region: E3_binding; pfam02817 1220533006110 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1220533006111 2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239 1220533006112 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1220533006113 TPP-binding site [chemical binding]; other site 1220533006114 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1220533006115 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1220533006116 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1220533006117 metal ion-dependent adhesion site (MIDAS); other site 1220533006118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533006119 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1220533006120 Walker A motif; other site 1220533006121 ATP binding site [chemical binding]; other site 1220533006122 Walker B motif; other site 1220533006123 arginine finger; other site 1220533006124 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1220533006125 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1220533006126 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1220533006127 E-class dimer interface [polypeptide binding]; other site 1220533006128 P-class dimer interface [polypeptide binding]; other site 1220533006129 active site 1220533006130 Cu2+ binding site [ion binding]; other site 1220533006131 Zn2+ binding site [ion binding]; other site 1220533006132 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533006133 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533006134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533006135 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533006136 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1220533006137 NlpC/P60 family; Region: NLPC_P60; pfam00877 1220533006138 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1220533006139 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1220533006140 active site 1220533006141 TDP-binding site; other site 1220533006142 acceptor substrate-binding pocket; other site 1220533006143 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1220533006144 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1220533006145 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1220533006146 multidrug efflux protein; Reviewed; Region: PRK01766 1220533006147 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1220533006148 cation binding site [ion binding]; other site 1220533006149 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1220533006150 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1220533006151 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1220533006152 rarD protein; Region: rarD; TIGR00688 1220533006153 EamA-like transporter family; Region: EamA; pfam00892 1220533006154 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1220533006155 GntP family permease; Region: GntP_permease; pfam02447 1220533006156 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1220533006157 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1220533006158 Predicted transcriptional regulators [Transcription]; Region: COG1733 1220533006159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533006160 dimerization interface [polypeptide binding]; other site 1220533006161 putative DNA binding site [nucleotide binding]; other site 1220533006162 putative Zn2+ binding site [ion binding]; other site 1220533006163 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1220533006164 dimer interface [polypeptide binding]; other site 1220533006165 FMN binding site [chemical binding]; other site 1220533006166 Predicted esterase [General function prediction only]; Region: COG0400 1220533006167 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1220533006168 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533006169 Zn binding site [ion binding]; other site 1220533006170 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1220533006171 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533006172 Zn binding site [ion binding]; other site 1220533006173 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1220533006174 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1220533006175 Na binding site [ion binding]; other site 1220533006176 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1220533006177 C-terminal peptidase (prc); Region: prc; TIGR00225 1220533006178 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1220533006179 protein binding site [polypeptide binding]; other site 1220533006180 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1220533006181 Catalytic dyad [active] 1220533006182 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1220533006183 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1220533006184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533006185 S-adenosylmethionine binding site [chemical binding]; other site 1220533006186 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1220533006187 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1220533006188 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1220533006189 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1220533006190 YodL-like; Region: YodL; pfam14191 1220533006191 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1220533006192 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1220533006193 active site 1220533006194 YozD-like protein; Region: YozD; pfam14162 1220533006195 hypothetical protein; Provisional; Region: PRK13672 1220533006196 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1220533006197 toxin interface [polypeptide binding]; other site 1220533006198 Zn binding site [ion binding]; other site 1220533006199 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1220533006200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533006201 FeS/SAM binding site; other site 1220533006202 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1220533006203 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1220533006204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533006205 Coenzyme A binding pocket [chemical binding]; other site 1220533006206 acetylornithine deacetylase; Validated; Region: PRK06915 1220533006207 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1220533006208 metal binding site [ion binding]; metal-binding site 1220533006209 dimer interface [polypeptide binding]; other site 1220533006210 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1220533006211 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1220533006212 hypothetical protein; Provisional; Region: PRK06917 1220533006213 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1220533006214 inhibitor-cofactor binding pocket; inhibition site 1220533006215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533006216 catalytic residue [active] 1220533006217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533006218 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1220533006219 Coenzyme A binding pocket [chemical binding]; other site 1220533006220 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1220533006221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533006222 active site 1220533006223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1220533006224 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1220533006225 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1220533006226 Phytase; Region: Phytase; pfam02333 1220533006227 Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331 1220533006228 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533006229 non-specific DNA binding site [nucleotide binding]; other site 1220533006230 salt bridge; other site 1220533006231 sequence-specific DNA binding site [nucleotide binding]; other site 1220533006232 Rubrerythrin [Energy production and conversion]; Region: COG1592 1220533006233 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1220533006234 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1220533006235 active site 1220533006236 metal binding site [ion binding]; metal-binding site 1220533006237 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1220533006238 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1220533006239 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1220533006240 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1220533006241 trimer interface [polypeptide binding]; other site 1220533006242 active site 1220533006243 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1220533006244 catalytic residues [active] 1220533006245 HNH endonuclease; Region: HNH_3; pfam13392 1220533006246 ribonucleoside-diphosphate reductase 2, operon protein nrdI; Region: nrdI; TIGR00333 1220533006247 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1220533006248 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1220533006249 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1220533006250 cofactor binding site; other site 1220533006251 DNA binding site [nucleotide binding] 1220533006252 substrate interaction site [chemical binding]; other site 1220533006253 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1220533006254 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1220533006255 AAA domain; Region: AAA_33; pfam13671 1220533006256 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1220533006257 active site 1220533006258 YorP protein; Region: YorP; pfam09629 1220533006259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1220533006260 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1220533006261 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1220533006262 active site 1220533006263 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1220533006264 DHH family; Region: DHH; pfam01368 1220533006265 hypothetical protein; Provisional; Region: PRK08624 1220533006266 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 1220533006267 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1220533006268 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1220533006269 ATP binding site [chemical binding]; other site 1220533006270 Walker B motif; other site 1220533006271 AAA domain; Region: AAA_24; pfam13479 1220533006272 Right handed beta helix region; Region: Beta_helix; pfam13229 1220533006273 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1220533006274 Phage-related replication protein [General function prediction only]; Region: COG4195 1220533006275 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1220533006276 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1220533006277 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1220533006278 active site 1220533006279 DNA binding site [nucleotide binding] 1220533006280 YoqO-like protein; Region: YoqO; pfam14037 1220533006281 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1220533006282 active site 1220533006283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4474 1220533006284 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1220533006285 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1220533006286 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1220533006287 YopX protein; Region: YopX; pfam09643 1220533006288 Hypothetical protein Yopt; Region: Yopt; pfam09467 1220533006289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533006290 salt bridge; other site 1220533006291 non-specific DNA binding site [nucleotide binding]; other site 1220533006292 sequence-specific DNA binding site [nucleotide binding]; other site 1220533006293 DNA-sulfur modification-associated; Region: DndB; pfam14072 1220533006294 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1220533006295 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1220533006296 active site 1220533006297 catalytic residues [active] 1220533006298 DNA binding site [nucleotide binding] 1220533006299 Int/Topo IB signature motif; other site 1220533006300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533006301 non-specific DNA binding site [nucleotide binding]; other site 1220533006302 salt bridge; other site 1220533006303 sequence-specific DNA binding site [nucleotide binding]; other site 1220533006304 Superinfection exclusion protein B; Region: SieB; pfam14163 1220533006305 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1220533006306 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1220533006307 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1220533006308 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533006309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533006310 non-specific DNA binding site [nucleotide binding]; other site 1220533006311 salt bridge; other site 1220533006312 sequence-specific DNA binding site [nucleotide binding]; other site 1220533006313 RNA dependent RNA polymerase; Region: RdRP; pfam05183 1220533006314 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1220533006315 IHF - DNA interface [nucleotide binding]; other site 1220533006316 IHF dimer interface [polypeptide binding]; other site 1220533006317 YonK protein; Region: YonK; pfam09642 1220533006318 Terminase-like family; Region: Terminase_6; pfam03237 1220533006319 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1220533006320 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1220533006321 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1220533006322 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1220533006323 active site 1220533006324 catalytic residues [active] 1220533006325 DNA binding site [nucleotide binding] 1220533006326 Int/Topo IB signature motif; other site 1220533006327 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1220533006328 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1220533006329 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1220533006330 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1220533006331 catalytic residue [active] 1220533006332 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1220533006333 Peptidase family M23; Region: Peptidase_M23; pfam01551 1220533006334 Phage-related protein [Function unknown]; Region: COG4722 1220533006335 Phage tail protein; Region: Sipho_tail; cl17486 1220533006336 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1220533006337 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 1220533006338 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1220533006339 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1220533006340 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1220533006341 amidase catalytic site [active] 1220533006342 Zn binding residues [ion binding]; other site 1220533006343 substrate binding site [chemical binding]; other site 1220533006344 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1220533006345 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1220533006346 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1220533006347 peptide S-glycosyltransferase, SunS family; Region: S_glycosyl_SunS; TIGR04195 1220533006348 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1220533006349 active site 1220533006350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1220533006351 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1220533006352 catalytic residues [active] 1220533006353 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1220533006354 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1220533006355 putative active site [active] 1220533006356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533006357 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1220533006358 Walker A/P-loop; other site 1220533006359 ATP binding site [chemical binding]; other site 1220533006360 Q-loop/lid; other site 1220533006361 ABC transporter signature motif; other site 1220533006362 Walker B; other site 1220533006363 D-loop; other site 1220533006364 H-loop/switch region; other site 1220533006365 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1220533006366 DNA polymerase IV; Reviewed; Region: PRK03103 1220533006367 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1220533006368 active site 1220533006369 DNA binding site [nucleotide binding] 1220533006370 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1220533006371 YolD-like protein; Region: YolD; pfam08863 1220533006372 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1220533006373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533006374 Coenzyme A binding pocket [chemical binding]; other site 1220533006375 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1220533006376 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1220533006377 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1220533006378 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1220533006379 Staphylococcal nuclease homologues; Region: SNc; smart00318 1220533006380 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1220533006381 Catalytic site; other site 1220533006382 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1220533006383 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1220533006384 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1220533006385 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1220533006386 catalytic residues [active] 1220533006387 catalytic nucleophile [active] 1220533006388 Recombinase; Region: Recombinase; pfam07508 1220533006389 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1220533006390 SelR domain; Region: SelR; pfam01641 1220533006391 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1220533006392 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533006393 MarR family; Region: MarR; pfam01047 1220533006394 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1220533006395 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1220533006396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 1220533006397 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1220533006398 active site 1220533006399 catalytic triad [active] 1220533006400 oxyanion hole [active] 1220533006401 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1220533006402 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1220533006403 Cu(I) binding site [ion binding]; other site 1220533006404 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1220533006405 threonine dehydratase; Validated; Region: PRK08639 1220533006406 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1220533006407 tetramer interface [polypeptide binding]; other site 1220533006408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533006409 catalytic residue [active] 1220533006410 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1220533006411 putative Ile/Val binding site [chemical binding]; other site 1220533006412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533006413 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1220533006414 Walker A motif; other site 1220533006415 ATP binding site [chemical binding]; other site 1220533006416 Walker B motif; other site 1220533006417 arginine finger; other site 1220533006418 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1220533006419 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1220533006420 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1220533006421 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1220533006422 putative acyl-acceptor binding pocket; other site 1220533006423 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1220533006424 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1220533006425 folate binding site [chemical binding]; other site 1220533006426 NADP+ binding site [chemical binding]; other site 1220533006427 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1220533006428 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1220533006429 dimerization interface [polypeptide binding]; other site 1220533006430 active site 1220533006431 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1220533006432 tetramer interfaces [polypeptide binding]; other site 1220533006433 binuclear metal-binding site [ion binding]; other site 1220533006434 YpjP-like protein; Region: YpjP; pfam14005 1220533006435 ribosomal biogenesis protein; Validated; Region: PRK00933 1220533006436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533006437 S-adenosylmethionine binding site [chemical binding]; other site 1220533006438 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1220533006439 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1220533006440 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1220533006441 Virulence factor; Region: Virulence_fact; pfam13769 1220533006442 HEAT repeats; Region: HEAT_2; pfam13646 1220533006443 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1220533006444 HEAT repeats; Region: HEAT_2; pfam13646 1220533006445 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1220533006446 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1220533006447 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1220533006448 Zn2+ binding site [ion binding]; other site 1220533006449 Mg2+ binding site [ion binding]; other site 1220533006450 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1220533006451 catalytic residues [active] 1220533006452 dimer interface [polypeptide binding]; other site 1220533006453 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1220533006454 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1220533006455 proposed active site lysine [active] 1220533006456 conserved cys residue [active] 1220533006457 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1220533006458 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1220533006459 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1220533006460 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1220533006461 DNA-binding site [nucleotide binding]; DNA binding site 1220533006462 RNA-binding motif; other site 1220533006463 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1220533006464 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1220533006465 hypothetical protein; Validated; Region: PRK07708 1220533006466 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1220533006467 RNA/DNA hybrid binding site [nucleotide binding]; other site 1220533006468 active site 1220533006469 conserved hypothetical integral membrane protein; Region: TIGR00697 1220533006470 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1220533006471 RNA/DNA hybrid binding site [nucleotide binding]; other site 1220533006472 active site 1220533006473 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1220533006474 5'-3' exonuclease; Region: 53EXOc; smart00475 1220533006475 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1220533006476 active site 1220533006477 metal binding site 1 [ion binding]; metal-binding site 1220533006478 putative 5' ssDNA interaction site; other site 1220533006479 metal binding site 3; metal-binding site 1220533006480 metal binding site 2 [ion binding]; metal-binding site 1220533006481 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1220533006482 putative DNA binding site [nucleotide binding]; other site 1220533006483 putative metal binding site [ion binding]; other site 1220533006484 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1220533006485 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1220533006486 Dynamin family; Region: Dynamin_N; pfam00350 1220533006487 G1 box; other site 1220533006488 GTP/Mg2+ binding site [chemical binding]; other site 1220533006489 G2 box; other site 1220533006490 Switch I region; other site 1220533006491 G3 box; other site 1220533006492 Switch II region; other site 1220533006493 G4 box; other site 1220533006494 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1220533006495 G1 box; other site 1220533006496 GTP/Mg2+ binding site [chemical binding]; other site 1220533006497 Dynamin family; Region: Dynamin_N; pfam00350 1220533006498 G2 box; other site 1220533006499 Switch I region; other site 1220533006500 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1220533006501 G3 box; other site 1220533006502 Switch II region; other site 1220533006503 GTP/Mg2+ binding site [chemical binding]; other site 1220533006504 G4 box; other site 1220533006505 G5 box; other site 1220533006506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1220533006507 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1220533006508 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1220533006509 malonyl-CoA binding site [chemical binding]; other site 1220533006510 dimer interface [polypeptide binding]; other site 1220533006511 active site 1220533006512 product binding site; other site 1220533006513 xanthine permease; Region: pbuX; TIGR03173 1220533006514 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1220533006515 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533006516 active site 1220533006517 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1220533006518 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1220533006519 active site 1220533006520 Zn binding site [ion binding]; other site 1220533006521 2-keto-3-deoxygluconate permease; Region: KdgT; pfam03812 1220533006522 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1220533006523 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1220533006524 active site 1220533006525 intersubunit interface [polypeptide binding]; other site 1220533006526 catalytic residue [active] 1220533006527 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1220533006528 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1220533006529 substrate binding site [chemical binding]; other site 1220533006530 ATP binding site [chemical binding]; other site 1220533006531 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1220533006532 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1220533006533 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1220533006534 NADP binding site [chemical binding]; other site 1220533006535 homodimer interface [polypeptide binding]; other site 1220533006536 active site 1220533006537 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1220533006538 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1220533006539 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1220533006540 YpzG-like protein; Region: YpzG; pfam14139 1220533006541 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1220533006542 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1220533006543 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1220533006544 cell division protein GpsB; Provisional; Region: PRK14127 1220533006545 DivIVA domain; Region: DivI1A_domain; TIGR03544 1220533006546 hypothetical protein; Provisional; Region: PRK13660 1220533006547 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1220533006548 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1220533006549 RNase_H superfamily; Region: RNase_H_2; pfam13482 1220533006550 active site 1220533006551 substrate binding site [chemical binding]; other site 1220533006552 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1220533006553 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1220533006554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533006555 ATP binding site [chemical binding]; other site 1220533006556 putative Mg++ binding site [ion binding]; other site 1220533006557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533006558 nucleotide binding region [chemical binding]; other site 1220533006559 ATP-binding site [chemical binding]; other site 1220533006560 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1220533006561 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1220533006562 HPr interaction site; other site 1220533006563 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1220533006564 active site 1220533006565 phosphorylation site [posttranslational modification] 1220533006566 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1220533006567 YppG-like protein; Region: YppG; pfam14179 1220533006568 YppF-like protein; Region: YppF; pfam14178 1220533006569 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1220533006570 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1220533006571 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1220533006572 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1220533006573 Transglycosylase; Region: Transgly; pfam00912 1220533006574 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1220533006575 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1220533006576 Interdomain contacts; other site 1220533006577 Cytokine receptor motif; other site 1220533006578 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1220533006579 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1220533006580 minor groove reading motif; other site 1220533006581 helix-hairpin-helix signature motif; other site 1220533006582 substrate binding pocket [chemical binding]; other site 1220533006583 active site 1220533006584 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1220533006585 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1220533006586 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1220533006587 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1220533006588 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1220533006589 putative dimer interface [polypeptide binding]; other site 1220533006590 putative anticodon binding site; other site 1220533006591 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1220533006592 homodimer interface [polypeptide binding]; other site 1220533006593 motif 1; other site 1220533006594 motif 2; other site 1220533006595 active site 1220533006596 motif 3; other site 1220533006597 aspartate aminotransferase; Provisional; Region: PRK05764 1220533006598 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533006599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533006600 homodimer interface [polypeptide binding]; other site 1220533006601 catalytic residue [active] 1220533006602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1220533006603 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1220533006604 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1220533006605 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1220533006606 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1220533006607 active site 1220533006608 catalytic site [active] 1220533006609 substrate binding site [chemical binding]; other site 1220533006610 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1220533006611 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1220533006612 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1220533006613 tetramerization interface [polypeptide binding]; other site 1220533006614 active site 1220533006615 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1220533006616 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1220533006617 active site 1220533006618 ATP-binding site [chemical binding]; other site 1220533006619 pantoate-binding site; other site 1220533006620 HXXH motif; other site 1220533006621 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1220533006622 oligomerization interface [polypeptide binding]; other site 1220533006623 active site 1220533006624 metal binding site [ion binding]; metal-binding site 1220533006625 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1220533006626 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1220533006627 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1220533006628 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1220533006629 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1220533006630 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1220533006631 active site 1220533006632 NTP binding site [chemical binding]; other site 1220533006633 metal binding triad [ion binding]; metal-binding site 1220533006634 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1220533006635 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1220533006636 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1220533006637 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1220533006638 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1220533006639 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1220533006640 active site 1220533006641 dimer interfaces [polypeptide binding]; other site 1220533006642 catalytic residues [active] 1220533006643 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1220533006644 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1220533006645 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1220533006646 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1220533006647 homodimer interface [polypeptide binding]; other site 1220533006648 metal binding site [ion binding]; metal-binding site 1220533006649 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1220533006650 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533006651 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533006652 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1220533006653 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1220533006654 Predicted membrane protein [Function unknown]; Region: COG4347 1220533006655 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1220533006656 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1220533006657 intrachain domain interface; other site 1220533006658 Qi binding site; other site 1220533006659 Qo binding site; other site 1220533006660 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1220533006661 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1220533006662 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1220533006663 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1220533006664 interchain domain interface [polypeptide binding]; other site 1220533006665 intrachain domain interface; other site 1220533006666 heme bH binding site [chemical binding]; other site 1220533006667 Qi binding site; other site 1220533006668 heme bL binding site [chemical binding]; other site 1220533006669 Qo binding site; other site 1220533006670 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1220533006671 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1220533006672 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1220533006673 iron-sulfur cluster [ion binding]; other site 1220533006674 [2Fe-2S] cluster binding site [ion binding]; other site 1220533006675 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1220533006676 hypothetical protein; Provisional; Region: PRK03636 1220533006677 UPF0302 domain; Region: UPF0302; pfam08864 1220533006678 IDEAL domain; Region: IDEAL; pfam08858 1220533006679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1220533006680 TPR motif; other site 1220533006681 binding surface 1220533006682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533006683 binding surface 1220533006684 TPR motif; other site 1220533006685 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1220533006686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533006687 TPR motif; other site 1220533006688 binding surface 1220533006689 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1220533006690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533006691 binding surface 1220533006692 TPR motif; other site 1220533006693 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1220533006694 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1220533006695 hinge; other site 1220533006696 active site 1220533006697 prephenate dehydrogenase; Validated; Region: PRK06545 1220533006698 prephenate dehydrogenase; Validated; Region: PRK08507 1220533006699 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1220533006700 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1220533006701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533006702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533006703 homodimer interface [polypeptide binding]; other site 1220533006704 catalytic residue [active] 1220533006705 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1220533006706 substrate binding site [chemical binding]; other site 1220533006707 active site 1220533006708 catalytic residues [active] 1220533006709 heterodimer interface [polypeptide binding]; other site 1220533006710 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1220533006711 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1220533006712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533006713 catalytic residue [active] 1220533006714 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1220533006715 active site 1220533006716 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1220533006717 active site 1220533006718 ribulose/triose binding site [chemical binding]; other site 1220533006719 phosphate binding site [ion binding]; other site 1220533006720 substrate (anthranilate) binding pocket [chemical binding]; other site 1220533006721 product (indole) binding pocket [chemical binding]; other site 1220533006722 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1220533006723 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1220533006724 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1220533006725 anthranilate synthase component I; Provisional; Region: PRK13569 1220533006726 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1220533006727 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1220533006728 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1220533006729 homotrimer interaction site [polypeptide binding]; other site 1220533006730 active site 1220533006731 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1220533006732 active site 1220533006733 dimer interface [polypeptide binding]; other site 1220533006734 metal binding site [ion binding]; metal-binding site 1220533006735 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1220533006736 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1220533006737 Tetramer interface [polypeptide binding]; other site 1220533006738 active site 1220533006739 FMN-binding site [chemical binding]; other site 1220533006740 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1220533006741 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1220533006742 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1220533006743 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1220533006744 active site 1220533006745 multimer interface [polypeptide binding]; other site 1220533006746 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1220533006747 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1220533006748 substrate binding pocket [chemical binding]; other site 1220533006749 chain length determination region; other site 1220533006750 substrate-Mg2+ binding site; other site 1220533006751 catalytic residues [active] 1220533006752 aspartate-rich region 1; other site 1220533006753 active site lid residues [active] 1220533006754 aspartate-rich region 2; other site 1220533006755 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1220533006756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533006757 S-adenosylmethionine binding site [chemical binding]; other site 1220533006758 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1220533006759 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1220533006760 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1220533006761 homodecamer interface [polypeptide binding]; other site 1220533006762 GTP cyclohydrolase I; Provisional; Region: PLN03044 1220533006763 active site 1220533006764 putative catalytic site residues [active] 1220533006765 zinc binding site [ion binding]; other site 1220533006766 GTP-CH-I/GFRP interaction surface; other site 1220533006767 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1220533006768 IHF dimer interface [polypeptide binding]; other site 1220533006769 IHF - DNA interface [nucleotide binding]; other site 1220533006770 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1220533006771 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1220533006772 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1220533006773 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1220533006774 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1220533006775 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1220533006776 GTP-binding protein Der; Reviewed; Region: PRK00093 1220533006777 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1220533006778 G1 box; other site 1220533006779 GTP/Mg2+ binding site [chemical binding]; other site 1220533006780 Switch I region; other site 1220533006781 G2 box; other site 1220533006782 Switch II region; other site 1220533006783 G3 box; other site 1220533006784 G4 box; other site 1220533006785 G5 box; other site 1220533006786 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1220533006787 G1 box; other site 1220533006788 GTP/Mg2+ binding site [chemical binding]; other site 1220533006789 Switch I region; other site 1220533006790 G2 box; other site 1220533006791 G3 box; other site 1220533006792 Switch II region; other site 1220533006793 G4 box; other site 1220533006794 G5 box; other site 1220533006795 YIEGIA protein; Region: YIEGIA; pfam14045 1220533006796 YpzI-like protein; Region: YpzI; pfam14140 1220533006797 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1220533006798 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1220533006799 homotetramer interface [polypeptide binding]; other site 1220533006800 FMN binding site [chemical binding]; other site 1220533006801 homodimer contacts [polypeptide binding]; other site 1220533006802 putative active site [active] 1220533006803 putative substrate binding site [chemical binding]; other site 1220533006804 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1220533006805 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1220533006806 RNA binding site [nucleotide binding]; other site 1220533006807 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1220533006808 RNA binding site [nucleotide binding]; other site 1220533006809 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1220533006810 RNA binding site [nucleotide binding]; other site 1220533006811 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1220533006812 RNA binding site [nucleotide binding]; other site 1220533006813 cytidylate kinase; Provisional; Region: cmk; PRK00023 1220533006814 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1220533006815 CMP-binding site; other site 1220533006816 The sites determining sugar specificity; other site 1220533006817 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1220533006818 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1220533006819 PilZ domain; Region: PilZ; pfam07238 1220533006820 germination protein YpeB; Region: spore_YpeB; TIGR02889 1220533006821 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1220533006822 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1220533006823 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1220533006824 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1220533006825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1220533006826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533006827 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1220533006828 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1220533006829 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1220533006830 NAD(P) binding site [chemical binding]; other site 1220533006831 adaptor protein; Provisional; Region: PRK02899 1220533006832 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1220533006833 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1220533006834 putative active site [active] 1220533006835 putative metal binding site [ion binding]; other site 1220533006836 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1220533006837 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533006838 CAAX protease self-immunity; Region: Abi; pfam02517 1220533006839 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1220533006840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533006841 ATP binding site [chemical binding]; other site 1220533006842 putative Mg++ binding site [ion binding]; other site 1220533006843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533006844 nucleotide binding region [chemical binding]; other site 1220533006845 ATP-binding site [chemical binding]; other site 1220533006846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1220533006847 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1220533006848 Predicted membrane protein [Function unknown]; Region: COG3601 1220533006849 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1220533006850 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1220533006851 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1220533006852 ligand binding site [chemical binding]; other site 1220533006853 NAD binding site [chemical binding]; other site 1220533006854 dimerization interface [polypeptide binding]; other site 1220533006855 catalytic site [active] 1220533006856 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1220533006857 putative L-serine binding site [chemical binding]; other site 1220533006858 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1220533006859 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1220533006860 active site 1220533006861 catalytic residue [active] 1220533006862 dimer interface [polypeptide binding]; other site 1220533006863 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1220533006864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533006865 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533006866 DNA binding residues [nucleotide binding] 1220533006867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1220533006868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533006869 dimerization interface [polypeptide binding]; other site 1220533006870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533006871 putative active site [active] 1220533006872 heme pocket [chemical binding]; other site 1220533006873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533006874 dimer interface [polypeptide binding]; other site 1220533006875 phosphorylation site [posttranslational modification] 1220533006876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533006877 ATP binding site [chemical binding]; other site 1220533006878 Mg2+ binding site [ion binding]; other site 1220533006879 G-X-G motif; other site 1220533006880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533006881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533006882 active site 1220533006883 phosphorylation site [posttranslational modification] 1220533006884 intermolecular recognition site; other site 1220533006885 dimerization interface [polypeptide binding]; other site 1220533006886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533006887 DNA binding site [nucleotide binding] 1220533006888 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1220533006889 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1220533006890 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1220533006891 ResB-like family; Region: ResB; pfam05140 1220533006892 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1220533006893 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1220533006894 catalytic residues [active] 1220533006895 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1220533006896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533006897 RNA binding surface [nucleotide binding]; other site 1220533006898 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1220533006899 active site 1220533006900 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1220533006901 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1220533006902 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1220533006903 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1220533006904 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1220533006905 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1220533006906 segregation and condensation protein B; Region: TIGR00281 1220533006907 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1220533006908 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1220533006909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533006910 Coenzyme A binding pocket [chemical binding]; other site 1220533006911 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1220533006912 homopentamer interface [polypeptide binding]; other site 1220533006913 active site 1220533006914 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1220533006915 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1220533006916 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1220533006917 dimerization interface [polypeptide binding]; other site 1220533006918 active site 1220533006919 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1220533006920 Lumazine binding domain; Region: Lum_binding; pfam00677 1220533006921 Lumazine binding domain; Region: Lum_binding; pfam00677 1220533006922 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1220533006923 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1220533006924 catalytic motif [active] 1220533006925 Zn binding site [ion binding]; other site 1220533006926 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1220533006927 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1220533006928 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1220533006929 Catalytic site [active] 1220533006930 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1220533006931 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1220533006932 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1220533006933 active site 1220533006934 Predicted secreted protein [Function unknown]; Region: COG4086 1220533006935 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1220533006936 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1220533006937 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1220533006938 active site 1220533006939 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1220533006940 substrate binding site [chemical binding]; other site 1220533006941 catalytic residues [active] 1220533006942 dimer interface [polypeptide binding]; other site 1220533006943 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1220533006944 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1220533006945 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1220533006946 stage V sporulation protein AD; Validated; Region: PRK08304 1220533006947 stage V sporulation protein AD; Provisional; Region: PRK12404 1220533006948 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1220533006949 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1220533006950 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1220533006951 sporulation sigma factor SigF; Validated; Region: PRK05572 1220533006952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533006953 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1220533006954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533006955 DNA binding residues [nucleotide binding] 1220533006956 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1220533006957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533006958 ATP binding site [chemical binding]; other site 1220533006959 Mg2+ binding site [ion binding]; other site 1220533006960 G-X-G motif; other site 1220533006961 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1220533006962 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1220533006963 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1220533006964 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1220533006965 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1220533006966 phosphopentomutase; Provisional; Region: PRK05362 1220533006967 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1220533006968 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1220533006969 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1220533006970 active site 1220533006971 Int/Topo IB signature motif; other site 1220533006972 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1220533006973 ferric uptake regulator; Provisional; Region: fur; PRK09462 1220533006974 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1220533006975 metal binding site 2 [ion binding]; metal-binding site 1220533006976 putative DNA binding helix; other site 1220533006977 metal binding site 1 [ion binding]; metal-binding site 1220533006978 dimer interface [polypeptide binding]; other site 1220533006979 structural Zn2+ binding site [ion binding]; other site 1220533006980 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1220533006981 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1220533006982 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1220533006983 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1220533006984 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1220533006985 NAD(P) binding pocket [chemical binding]; other site 1220533006986 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1220533006987 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1220533006988 Aspartase; Region: Aspartase; cd01357 1220533006989 active sites [active] 1220533006990 tetramer interface [polypeptide binding]; other site 1220533006991 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1220533006992 active site 1220533006993 homodimer interface [polypeptide binding]; other site 1220533006994 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533006995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533006996 non-specific DNA binding site [nucleotide binding]; other site 1220533006997 salt bridge; other site 1220533006998 sequence-specific DNA binding site [nucleotide binding]; other site 1220533006999 TIGR00375 family protein; Region: TIGR00375 1220533007000 PHP-associated; Region: PHP_C; pfam13263 1220533007001 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1220533007002 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1220533007003 dimer interface [polypeptide binding]; other site 1220533007004 ADP-ribose binding site [chemical binding]; other site 1220533007005 active site 1220533007006 nudix motif; other site 1220533007007 metal binding site [ion binding]; metal-binding site 1220533007008 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1220533007009 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1220533007010 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1220533007011 active site 1220533007012 catalytic tetrad [active] 1220533007013 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1220533007014 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1220533007015 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1220533007016 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1220533007017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1220533007018 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1220533007019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533007020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1220533007021 Coenzyme A binding pocket [chemical binding]; other site 1220533007022 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1220533007023 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1220533007024 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1220533007025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533007026 Coenzyme A binding pocket [chemical binding]; other site 1220533007027 YolD-like protein; Region: YolD; pfam08863 1220533007028 DNA polymerase IV; Reviewed; Region: PRK03103 1220533007029 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1220533007030 active site 1220533007031 DNA binding site [nucleotide binding] 1220533007032 YqzH-like protein; Region: YqzH; pfam14164 1220533007033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533007034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533007035 putative substrate translocation pore; other site 1220533007036 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1220533007037 putative dimer interface [polypeptide binding]; other site 1220533007038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533007039 ligand binding site [chemical binding]; other site 1220533007040 Zn binding site [ion binding]; other site 1220533007041 pantothenate kinase; Provisional; Region: PRK05439 1220533007042 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1220533007043 ATP-binding site [chemical binding]; other site 1220533007044 CoA-binding site [chemical binding]; other site 1220533007045 Mg2+-binding site [ion binding]; other site 1220533007046 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1220533007047 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1220533007048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1220533007049 catalytic residue [active] 1220533007050 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1220533007051 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1220533007052 NADP binding site [chemical binding]; other site 1220533007053 homodimer interface [polypeptide binding]; other site 1220533007054 substrate binding site [chemical binding]; other site 1220533007055 active site 1220533007056 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1220533007057 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1220533007058 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1220533007059 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1220533007060 putative metal binding site [ion binding]; other site 1220533007061 putative dimer interface [polypeptide binding]; other site 1220533007062 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1220533007063 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1220533007064 active site 1220533007065 FMN binding site [chemical binding]; other site 1220533007066 substrate binding site [chemical binding]; other site 1220533007067 homotetramer interface [polypeptide binding]; other site 1220533007068 catalytic residue [active] 1220533007069 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1220533007070 putative hydrolase; Provisional; Region: PRK02113 1220533007071 ribonuclease Z; Region: RNase_Z; TIGR02651 1220533007072 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1220533007073 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1220533007074 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1220533007075 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1220533007076 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1220533007077 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1220533007078 DNA polymerase IV; Validated; Region: PRK01810 1220533007079 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1220533007080 active site 1220533007081 DNA binding site [nucleotide binding] 1220533007082 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1220533007083 OxaA-like protein precursor; Validated; Region: PRK01622 1220533007084 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1220533007085 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 1220533007086 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1220533007087 peptidase T-like protein; Region: PepT-like; TIGR01883 1220533007088 metal binding site [ion binding]; metal-binding site 1220533007089 putative dimer interface [polypeptide binding]; other site 1220533007090 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1220533007091 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1220533007092 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1220533007093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533007094 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1220533007095 dimer interface [polypeptide binding]; other site 1220533007096 substrate binding site [chemical binding]; other site 1220533007097 metal binding site [ion binding]; metal-binding site 1220533007098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1220533007099 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1220533007100 Predicted membrane protein [Function unknown]; Region: COG4129 1220533007101 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1220533007102 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1220533007103 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1220533007104 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1220533007105 Walker A/P-loop; other site 1220533007106 ATP binding site [chemical binding]; other site 1220533007107 Q-loop/lid; other site 1220533007108 ABC transporter signature motif; other site 1220533007109 Walker B; other site 1220533007110 D-loop; other site 1220533007111 H-loop/switch region; other site 1220533007112 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1220533007113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533007114 dimer interface [polypeptide binding]; other site 1220533007115 conserved gate region; other site 1220533007116 putative PBP binding loops; other site 1220533007117 ABC-ATPase subunit interface; other site 1220533007118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1220533007119 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1220533007120 substrate binding pocket [chemical binding]; other site 1220533007121 membrane-bound complex binding site; other site 1220533007122 hinge residues; other site 1220533007123 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1220533007124 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1220533007125 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1220533007126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533007127 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533007128 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1220533007129 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1220533007130 DNA binding residues [nucleotide binding] 1220533007131 drug binding residues [chemical binding]; other site 1220533007132 dimer interface [polypeptide binding]; other site 1220533007133 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1220533007134 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1220533007135 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1220533007136 E3 interaction surface; other site 1220533007137 lipoyl attachment site [posttranslational modification]; other site 1220533007138 e3 binding domain; Region: E3_binding; pfam02817 1220533007139 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1220533007140 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1220533007141 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1220533007142 alpha subunit interface [polypeptide binding]; other site 1220533007143 TPP binding site [chemical binding]; other site 1220533007144 heterodimer interface [polypeptide binding]; other site 1220533007145 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1220533007146 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1220533007147 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1220533007148 tetramer interface [polypeptide binding]; other site 1220533007149 TPP-binding site [chemical binding]; other site 1220533007150 heterodimer interface [polypeptide binding]; other site 1220533007151 phosphorylation loop region [posttranslational modification] 1220533007152 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1220533007153 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1220533007154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533007155 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1220533007156 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1220533007157 nucleotide binding site [chemical binding]; other site 1220533007158 Acetokinase family; Region: Acetate_kinase; cl17229 1220533007159 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1220533007160 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1220533007161 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1220533007162 NAD binding site [chemical binding]; other site 1220533007163 Phe binding site; other site 1220533007164 phosphate butyryltransferase; Validated; Region: PRK07742 1220533007165 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1220533007166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533007167 putative active site [active] 1220533007168 heme pocket [chemical binding]; other site 1220533007169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533007170 putative active site [active] 1220533007171 heme pocket [chemical binding]; other site 1220533007172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533007173 Walker A motif; other site 1220533007174 ATP binding site [chemical binding]; other site 1220533007175 Walker B motif; other site 1220533007176 arginine finger; other site 1220533007177 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1220533007178 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1220533007179 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1220533007180 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1220533007181 tetramer interface [polypeptide binding]; other site 1220533007182 active site 1220533007183 Mg2+/Mn2+ binding site [ion binding]; other site 1220533007184 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1220533007185 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1220533007186 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1220533007187 dimer interface [polypeptide binding]; other site 1220533007188 Citrate synthase; Region: Citrate_synt; pfam00285 1220533007189 active site 1220533007190 coenzyme A binding site [chemical binding]; other site 1220533007191 citrylCoA binding site [chemical binding]; other site 1220533007192 oxalacetate/citrate binding site [chemical binding]; other site 1220533007193 catalytic triad [active] 1220533007194 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1220533007195 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1220533007196 FAD binding site [chemical binding]; other site 1220533007197 homotetramer interface [polypeptide binding]; other site 1220533007198 substrate binding pocket [chemical binding]; other site 1220533007199 catalytic base [active] 1220533007200 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1220533007201 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1220533007202 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1220533007203 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1220533007204 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1220533007205 dimer interface [polypeptide binding]; other site 1220533007206 active site 1220533007207 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1220533007208 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1220533007209 active site 1220533007210 catalytic site [active] 1220533007211 metal binding site [ion binding]; metal-binding site 1220533007212 dimer interface [polypeptide binding]; other site 1220533007213 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1220533007214 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1220533007215 active site 1220533007216 metal binding site [ion binding]; metal-binding site 1220533007217 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1220533007218 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1220533007219 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1220533007220 putative active site [active] 1220533007221 putative FMN binding site [chemical binding]; other site 1220533007222 putative substrate binding site [chemical binding]; other site 1220533007223 putative catalytic residue [active] 1220533007224 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1220533007225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533007226 active site 1220533007227 phosphorylation site [posttranslational modification] 1220533007228 intermolecular recognition site; other site 1220533007229 dimerization interface [polypeptide binding]; other site 1220533007230 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1220533007231 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1220533007232 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1220533007233 protein binding site [polypeptide binding]; other site 1220533007234 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1220533007235 DNA repair protein RecN; Region: recN; TIGR00634 1220533007236 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1220533007237 Walker A/P-loop; other site 1220533007238 ATP binding site [chemical binding]; other site 1220533007239 Q-loop/lid; other site 1220533007240 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1220533007241 ABC transporter signature motif; other site 1220533007242 Walker B; other site 1220533007243 D-loop; other site 1220533007244 H-loop/switch region; other site 1220533007245 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1220533007246 arginine repressor; Provisional; Region: PRK04280 1220533007247 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1220533007248 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1220533007249 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533007250 RNA binding surface [nucleotide binding]; other site 1220533007251 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1220533007252 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1220533007253 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1220533007254 TPP-binding site; other site 1220533007255 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1220533007256 PYR/PP interface [polypeptide binding]; other site 1220533007257 dimer interface [polypeptide binding]; other site 1220533007258 TPP binding site [chemical binding]; other site 1220533007259 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1220533007260 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1220533007261 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1220533007262 substrate binding pocket [chemical binding]; other site 1220533007263 chain length determination region; other site 1220533007264 substrate-Mg2+ binding site; other site 1220533007265 catalytic residues [active] 1220533007266 aspartate-rich region 1; other site 1220533007267 active site lid residues [active] 1220533007268 aspartate-rich region 2; other site 1220533007269 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1220533007270 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1220533007271 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1220533007272 generic binding surface II; other site 1220533007273 generic binding surface I; other site 1220533007274 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1220533007275 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1220533007276 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1220533007277 homodimer interface [polypeptide binding]; other site 1220533007278 NADP binding site [chemical binding]; other site 1220533007279 substrate binding site [chemical binding]; other site 1220533007280 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1220533007281 putative RNA binding site [nucleotide binding]; other site 1220533007282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1220533007283 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1220533007284 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1220533007285 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1220533007286 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1220533007287 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1220533007288 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1220533007289 carboxyltransferase (CT) interaction site; other site 1220533007290 biotinylation site [posttranslational modification]; other site 1220533007291 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1220533007292 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1220533007293 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1220533007294 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1220533007295 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1220533007296 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1220533007297 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1220533007298 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1220533007299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533007300 Walker A motif; other site 1220533007301 ATP binding site [chemical binding]; other site 1220533007302 Walker B motif; other site 1220533007303 arginine finger; other site 1220533007304 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1220533007305 elongation factor P; Validated; Region: PRK00529 1220533007306 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1220533007307 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1220533007308 RNA binding site [nucleotide binding]; other site 1220533007309 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1220533007310 RNA binding site [nucleotide binding]; other site 1220533007311 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1220533007312 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1220533007313 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1220533007314 active site 1220533007315 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1220533007316 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1220533007317 trimer interface [polypeptide binding]; other site 1220533007318 active site 1220533007319 dimer interface [polypeptide binding]; other site 1220533007320 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1220533007321 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1220533007322 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1220533007323 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1220533007324 active site 1220533007325 nucleophile elbow; other site 1220533007326 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1220533007327 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1220533007328 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1220533007329 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1220533007330 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1220533007331 active site residue [active] 1220533007332 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1220533007333 tetramer interface [polypeptide binding]; other site 1220533007334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533007335 catalytic residue [active] 1220533007336 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1220533007337 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1220533007338 tetramer interface [polypeptide binding]; other site 1220533007339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533007340 catalytic residue [active] 1220533007341 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1220533007342 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1220533007343 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1220533007344 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1220533007345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533007346 ATP binding site [chemical binding]; other site 1220533007347 putative Mg++ binding site [ion binding]; other site 1220533007348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533007349 nucleotide binding region [chemical binding]; other site 1220533007350 ATP-binding site [chemical binding]; other site 1220533007351 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1220533007352 Anti-repressor SinI; Region: SinI; pfam08671 1220533007353 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533007354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533007355 non-specific DNA binding site [nucleotide binding]; other site 1220533007356 salt bridge; other site 1220533007357 sequence-specific DNA binding site [nucleotide binding]; other site 1220533007358 Anti-repressor SinI; Region: SinI; pfam08671 1220533007359 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1220533007360 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1220533007361 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1220533007362 Catalytic site [active] 1220533007363 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1220533007364 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1220533007365 YqzE-like protein; Region: YqzE; pfam14038 1220533007366 ComG operon protein 7; Region: ComGG; pfam14173 1220533007367 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1220533007368 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1220533007369 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1220533007370 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1220533007371 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1220533007372 Type II/IV secretion system protein; Region: T2SE; pfam00437 1220533007373 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1220533007374 Walker A motif; other site 1220533007375 ATP binding site [chemical binding]; other site 1220533007376 Walker B motif; other site 1220533007377 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1220533007378 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1220533007379 Cl binding site [ion binding]; other site 1220533007380 oligomer interface [polypeptide binding]; other site 1220533007381 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1220533007382 Domain of unknown function DUF21; Region: DUF21; pfam01595 1220533007383 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1220533007384 Transporter associated domain; Region: CorC_HlyC; smart01091 1220533007385 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1220533007386 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1220533007387 ArsC family; Region: ArsC; pfam03960 1220533007388 putative catalytic residues [active] 1220533007389 thiol/disulfide switch; other site 1220533007390 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1220533007391 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1220533007392 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1220533007393 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1220533007394 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1220533007395 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1220533007396 putative active site [active] 1220533007397 Zn binding site [ion binding]; other site 1220533007398 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1220533007399 Sulfatase; Region: Sulfatase; pfam00884 1220533007400 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1220533007401 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1220533007402 nucleotide binding site [chemical binding]; other site 1220533007403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1220533007404 Rhomboid family; Region: Rhomboid; pfam01694 1220533007405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533007406 binding surface 1220533007407 TPR motif; other site 1220533007408 TPR repeat; Region: TPR_11; pfam13414 1220533007409 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1220533007410 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1220533007411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1220533007412 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1220533007413 YceG-like family; Region: YceG; pfam02618 1220533007414 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1220533007415 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1220533007416 Walker A/P-loop; other site 1220533007417 ATP binding site [chemical binding]; other site 1220533007418 Q-loop/lid; other site 1220533007419 ABC transporter signature motif; other site 1220533007420 Walker B; other site 1220533007421 D-loop; other site 1220533007422 H-loop/switch region; other site 1220533007423 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1220533007424 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1220533007425 Walker A/P-loop; other site 1220533007426 ATP binding site [chemical binding]; other site 1220533007427 Q-loop/lid; other site 1220533007428 ABC transporter signature motif; other site 1220533007429 Walker B; other site 1220533007430 D-loop; other site 1220533007431 H-loop/switch region; other site 1220533007432 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1220533007433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533007434 dimer interface [polypeptide binding]; other site 1220533007435 conserved gate region; other site 1220533007436 ABC-ATPase subunit interface; other site 1220533007437 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1220533007438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533007439 dimer interface [polypeptide binding]; other site 1220533007440 conserved gate region; other site 1220533007441 putative PBP binding loops; other site 1220533007442 ABC-ATPase subunit interface; other site 1220533007443 PBP superfamily domain; Region: PBP_like_2; cl17296 1220533007444 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1220533007445 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1220533007446 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1220533007447 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1220533007448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533007449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533007450 putative substrate translocation pore; other site 1220533007451 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1220533007452 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1220533007453 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1220533007454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1220533007455 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1220533007456 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533007457 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1220533007458 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1220533007459 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1220533007460 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1220533007461 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1220533007462 ferric uptake regulator; Provisional; Region: fur; PRK09462 1220533007463 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1220533007464 metal binding site 2 [ion binding]; metal-binding site 1220533007465 putative DNA binding helix; other site 1220533007466 metal binding site 1 [ion binding]; metal-binding site 1220533007467 dimer interface [polypeptide binding]; other site 1220533007468 structural Zn2+ binding site [ion binding]; other site 1220533007469 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1220533007470 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533007471 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533007472 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1220533007473 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1220533007474 endonuclease IV; Provisional; Region: PRK01060 1220533007475 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1220533007476 AP (apurinic/apyrimidinic) site pocket; other site 1220533007477 DNA interaction; other site 1220533007478 Metal-binding active site; metal-binding site 1220533007479 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1220533007480 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1220533007481 ATP binding site [chemical binding]; other site 1220533007482 Mg++ binding site [ion binding]; other site 1220533007483 motif III; other site 1220533007484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533007485 nucleotide binding region [chemical binding]; other site 1220533007486 ATP-binding site [chemical binding]; other site 1220533007487 YqfQ-like protein; Region: YqfQ; pfam14181 1220533007488 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1220533007489 LytB protein; Region: LYTB; pfam02401 1220533007490 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1220533007491 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 1220533007492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1220533007493 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1220533007494 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1220533007495 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1220533007496 Family of unknown function (DUF633); Region: DUF633; pfam04816 1220533007497 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1220533007498 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1220533007499 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1220533007500 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1220533007501 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1220533007502 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533007503 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1220533007504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533007505 DNA binding residues [nucleotide binding] 1220533007506 DNA primase; Validated; Region: dnaG; PRK05667 1220533007507 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1220533007508 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1220533007509 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1220533007510 active site 1220533007511 metal binding site [ion binding]; metal-binding site 1220533007512 interdomain interaction site; other site 1220533007513 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1220533007514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1220533007515 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1220533007516 HTH domain; Region: HTH_11; pfam08279 1220533007517 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1220533007518 FOG: CBS domain [General function prediction only]; Region: COG0517 1220533007519 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1220533007520 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1220533007521 dimer interface [polypeptide binding]; other site 1220533007522 motif 1; other site 1220533007523 active site 1220533007524 motif 2; other site 1220533007525 motif 3; other site 1220533007526 T-box; B657_miscRNA39 1220533007527 Recombination protein O N terminal; Region: RecO_N; pfam11967 1220533007528 DNA repair protein RecO; Region: reco; TIGR00613 1220533007529 Recombination protein O C terminal; Region: RecO_C; pfam02565 1220533007530 YqzL-like protein; Region: YqzL; pfam14006 1220533007531 GTPase Era; Reviewed; Region: era; PRK00089 1220533007532 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1220533007533 G1 box; other site 1220533007534 GTP/Mg2+ binding site [chemical binding]; other site 1220533007535 Switch I region; other site 1220533007536 G2 box; other site 1220533007537 Switch II region; other site 1220533007538 G3 box; other site 1220533007539 G4 box; other site 1220533007540 G5 box; other site 1220533007541 KH domain; Region: KH_2; pfam07650 1220533007542 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1220533007543 active site 1220533007544 catalytic motif [active] 1220533007545 Zn binding site [ion binding]; other site 1220533007546 Predicted membrane protein [Function unknown]; Region: COG3223 1220533007547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533007548 HAMP domain; Region: HAMP; pfam00672 1220533007549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533007550 dimer interface [polypeptide binding]; other site 1220533007551 phosphorylation site [posttranslational modification] 1220533007552 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1220533007553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533007554 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1220533007555 active site 1220533007556 phosphorylation site [posttranslational modification] 1220533007557 intermolecular recognition site; other site 1220533007558 dimerization interface [polypeptide binding]; other site 1220533007559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533007560 DNA binding site [nucleotide binding] 1220533007561 Predicted membrane protein [Function unknown]; Region: COG2311 1220533007562 Protein of unknown function (DUF418); Region: DUF418; cl12135 1220533007563 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1220533007564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533007565 Coenzyme A binding pocket [chemical binding]; other site 1220533007566 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1220533007567 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1220533007568 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1220533007569 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1220533007570 CPxP motif; other site 1220533007571 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1220533007572 active site residue [active] 1220533007573 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1220533007574 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1220533007575 CPxP motif; other site 1220533007576 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1220533007577 active site residue [active] 1220533007578 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1220533007579 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1220533007580 putative homodimer interface [polypeptide binding]; other site 1220533007581 putative homotetramer interface [polypeptide binding]; other site 1220533007582 putative metal binding site [ion binding]; other site 1220533007583 putative homodimer-homodimer interface [polypeptide binding]; other site 1220533007584 putative allosteric switch controlling residues; other site 1220533007585 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1220533007586 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1220533007587 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1220533007588 DNA binding residues [nucleotide binding] 1220533007589 dimer interface [polypeptide binding]; other site 1220533007590 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1220533007591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533007592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533007593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533007594 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1220533007595 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1220533007596 Coenzyme A binding pocket [chemical binding]; other site 1220533007597 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1220533007598 Domain of unknown function DUF21; Region: DUF21; pfam01595 1220533007599 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1220533007600 Transporter associated domain; Region: CorC_HlyC; smart01091 1220533007601 YrzO-like protein; Region: YrzO; pfam14142 1220533007602 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1220533007603 EamA-like transporter family; Region: EamA; pfam00892 1220533007604 EamA-like transporter family; Region: EamA; pfam00892 1220533007605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533007606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533007607 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1220533007608 putative dimerization interface [polypeptide binding]; other site 1220533007609 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1220533007610 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1220533007611 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1220533007612 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1220533007613 Tautomerase enzyme; Region: Tautomerase; pfam01361 1220533007614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533007615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533007616 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1220533007617 putative dimerization interface [polypeptide binding]; other site 1220533007618 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1220533007619 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1220533007620 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1220533007621 4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346 1220533007622 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1220533007623 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533007624 putative DNA binding site [nucleotide binding]; other site 1220533007625 putative Zn2+ binding site [ion binding]; other site 1220533007626 AsnC family; Region: AsnC_trans_reg; pfam01037 1220533007627 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1220533007628 RNAase interaction site [polypeptide binding]; other site 1220533007629 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1220533007630 Cytochrome P450; Region: p450; cl12078 1220533007631 Isochorismatase family; Region: Isochorismatase; pfam00857 1220533007632 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1220533007633 catalytic triad [active] 1220533007634 conserved cis-peptide bond; other site 1220533007635 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1220533007636 DinB family; Region: DinB; pfam05163 1220533007637 DinB superfamily; Region: DinB_2; pfam12867 1220533007638 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1220533007639 Nitronate monooxygenase; Region: NMO; pfam03060 1220533007640 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1220533007641 FMN binding site [chemical binding]; other site 1220533007642 substrate binding site [chemical binding]; other site 1220533007643 putative catalytic residue [active] 1220533007644 glutamate racemase; Region: glut_race; TIGR00067 1220533007645 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1220533007646 putative binding site; other site 1220533007647 putative dimer interface [polypeptide binding]; other site 1220533007648 YodA lipocalin-like domain; Region: YodA; pfam09223 1220533007649 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 1220533007650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533007651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533007652 DNA binding residues [nucleotide binding] 1220533007653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1220533007654 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1220533007655 active site 1220533007656 catalytic tetrad [active] 1220533007657 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1220533007658 Citrate transporter; Region: CitMHS; pfam03600 1220533007659 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533007660 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533007661 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533007662 dimerization interface [polypeptide binding]; other site 1220533007663 PrpF protein; Region: PrpF; pfam04303 1220533007664 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1220533007665 chitosan binding site [chemical binding]; other site 1220533007666 catalytic residues [active] 1220533007667 Mor transcription activator family; Region: Mor; cl02360 1220533007668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533007669 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1220533007670 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1220533007671 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1220533007672 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1220533007673 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1220533007674 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533007675 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1220533007676 active site 1220533007677 metal binding site [ion binding]; metal-binding site 1220533007678 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1220533007679 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1220533007680 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1220533007681 NAD binding site [chemical binding]; other site 1220533007682 catalytic Zn binding site [ion binding]; other site 1220533007683 structural Zn binding site [ion binding]; other site 1220533007684 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1220533007685 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1220533007686 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1220533007687 DNA binding residues [nucleotide binding] 1220533007688 putative dimer interface [polypeptide binding]; other site 1220533007689 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1220533007690 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1220533007691 putative NAD(P) binding site [chemical binding]; other site 1220533007692 putative substrate binding site [chemical binding]; other site 1220533007693 catalytic Zn binding site [ion binding]; other site 1220533007694 structural Zn binding site [ion binding]; other site 1220533007695 dimer interface [polypeptide binding]; other site 1220533007696 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1220533007697 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1220533007698 proposed catalytic triad [active] 1220533007699 conserved cys residue [active] 1220533007700 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1220533007701 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1220533007702 substrate binding [chemical binding]; other site 1220533007703 active site 1220533007704 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1220533007705 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1220533007706 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1220533007707 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1220533007708 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1220533007709 active site 1220533007710 phosphorylation site [posttranslational modification] 1220533007711 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1220533007712 active pocket/dimerization site; other site 1220533007713 active site 1220533007714 phosphorylation site [posttranslational modification] 1220533007715 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1220533007716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533007717 Walker A motif; other site 1220533007718 ATP binding site [chemical binding]; other site 1220533007719 Walker B motif; other site 1220533007720 arginine finger; other site 1220533007721 Transcriptional antiterminator [Transcription]; Region: COG3933 1220533007722 PRD domain; Region: PRD; pfam00874 1220533007723 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1220533007724 active pocket/dimerization site; other site 1220533007725 active site 1220533007726 phosphorylation site [posttranslational modification] 1220533007727 PRD domain; Region: PRD; pfam00874 1220533007728 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1220533007729 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1220533007730 Predicted transcriptional regulators [Transcription]; Region: COG1378 1220533007731 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1220533007732 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1220533007733 C-terminal domain interface [polypeptide binding]; other site 1220533007734 sugar binding site [chemical binding]; other site 1220533007735 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1220533007736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533007737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533007738 DNA binding residues [nucleotide binding] 1220533007739 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1220533007740 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1220533007741 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1220533007742 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1220533007743 catalytic triad [active] 1220533007744 catalytic triad [active] 1220533007745 oxyanion hole [active] 1220533007746 YrhK-like protein; Region: YrhK; pfam14145 1220533007747 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1220533007748 Cytochrome P450; Region: p450; pfam00067 1220533007749 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1220533007750 Flavodoxin; Region: Flavodoxin_1; pfam00258 1220533007751 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1220533007752 FAD binding pocket [chemical binding]; other site 1220533007753 FAD binding motif [chemical binding]; other site 1220533007754 catalytic residues [active] 1220533007755 NAD binding pocket [chemical binding]; other site 1220533007756 phosphate binding motif [ion binding]; other site 1220533007757 beta-alpha-beta structure motif; other site 1220533007758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533007759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533007760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533007761 S-adenosylmethionine binding site [chemical binding]; other site 1220533007762 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1220533007763 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1220533007764 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1220533007765 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1220533007766 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1220533007767 catalytic loop [active] 1220533007768 iron binding site [ion binding]; other site 1220533007769 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1220533007770 4Fe-4S binding domain; Region: Fer4; pfam00037 1220533007771 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1220533007772 [4Fe-4S] binding site [ion binding]; other site 1220533007773 molybdopterin cofactor binding site; other site 1220533007774 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1220533007775 molybdopterin cofactor binding site; other site 1220533007776 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1220533007777 YrhC-like protein; Region: YrhC; pfam14143 1220533007778 cystathionine beta-lyase; Provisional; Region: PRK07671 1220533007779 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1220533007780 homodimer interface [polypeptide binding]; other site 1220533007781 substrate-cofactor binding pocket; other site 1220533007782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533007783 catalytic residue [active] 1220533007784 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1220533007785 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1220533007786 dimer interface [polypeptide binding]; other site 1220533007787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533007788 catalytic residue [active] 1220533007789 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1220533007790 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1220533007791 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1220533007792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533007793 S-adenosylmethionine binding site [chemical binding]; other site 1220533007794 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1220533007795 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1220533007796 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1220533007797 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1220533007798 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1220533007799 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1220533007800 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1220533007801 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1220533007802 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1220533007803 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1220533007804 ATP-binding site [chemical binding]; other site 1220533007805 Sugar specificity; other site 1220533007806 Pyrimidine base specificity; other site 1220533007807 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1220533007808 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1220533007809 Peptidase family U32; Region: Peptidase_U32; pfam01136 1220533007810 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1220533007811 Peptidase family U32; Region: Peptidase_U32; pfam01136 1220533007812 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1220533007813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533007814 S-adenosylmethionine binding site [chemical binding]; other site 1220533007815 conserved hypothetical protein, YceG family; Region: TIGR00247 1220533007816 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1220533007817 dimerization interface [polypeptide binding]; other site 1220533007818 hypothetical protein; Provisional; Region: PRK13678 1220533007819 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1220533007820 hypothetical protein; Provisional; Region: PRK05473 1220533007821 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1220533007822 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1220533007823 motif 1; other site 1220533007824 active site 1220533007825 motif 2; other site 1220533007826 motif 3; other site 1220533007827 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1220533007828 DHHA1 domain; Region: DHHA1; pfam02272 1220533007829 T-box; B657_miscRNA40 1220533007830 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1220533007831 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1220533007832 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1220533007833 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1220533007834 Walker A/P-loop; other site 1220533007835 ATP binding site [chemical binding]; other site 1220533007836 Q-loop/lid; other site 1220533007837 ABC transporter signature motif; other site 1220533007838 Walker B; other site 1220533007839 D-loop; other site 1220533007840 H-loop/switch region; other site 1220533007841 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1220533007842 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1220533007843 substrate binding pocket [chemical binding]; other site 1220533007844 membrane-bound complex binding site; other site 1220533007845 hinge residues; other site 1220533007846 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1220533007847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533007848 dimer interface [polypeptide binding]; other site 1220533007849 conserved gate region; other site 1220533007850 putative PBP binding loops; other site 1220533007851 ABC-ATPase subunit interface; other site 1220533007852 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1220533007853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533007854 dimer interface [polypeptide binding]; other site 1220533007855 ABC-ATPase subunit interface; other site 1220533007856 putative PBP binding loops; other site 1220533007857 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1220533007858 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1220533007859 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1220533007860 AAA domain; Region: AAA_30; pfam13604 1220533007861 Family description; Region: UvrD_C_2; pfam13538 1220533007862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533007863 TPR motif; other site 1220533007864 TPR repeat; Region: TPR_11; pfam13414 1220533007865 binding surface 1220533007866 TPR repeat; Region: TPR_11; pfam13414 1220533007867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533007868 binding surface 1220533007869 TPR motif; other site 1220533007870 TPR repeat; Region: TPR_11; pfam13414 1220533007871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533007872 binding surface 1220533007873 TPR motif; other site 1220533007874 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1220533007875 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1220533007876 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1220533007877 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1220533007878 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1220533007879 catalytic residue [active] 1220533007880 Predicted transcriptional regulator [Transcription]; Region: COG1959 1220533007881 Transcriptional regulator; Region: Rrf2; pfam02082 1220533007882 recombination factor protein RarA; Reviewed; Region: PRK13342 1220533007883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533007884 Walker A motif; other site 1220533007885 ATP binding site [chemical binding]; other site 1220533007886 Walker B motif; other site 1220533007887 arginine finger; other site 1220533007888 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1220533007889 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1220533007890 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1220533007891 putative ATP binding site [chemical binding]; other site 1220533007892 putative substrate interface [chemical binding]; other site 1220533007893 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1220533007894 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1220533007895 dimer interface [polypeptide binding]; other site 1220533007896 anticodon binding site; other site 1220533007897 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1220533007898 homodimer interface [polypeptide binding]; other site 1220533007899 motif 1; other site 1220533007900 active site 1220533007901 motif 2; other site 1220533007902 GAD domain; Region: GAD; pfam02938 1220533007903 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1220533007904 motif 3; other site 1220533007905 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1220533007906 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1220533007907 dimer interface [polypeptide binding]; other site 1220533007908 motif 1; other site 1220533007909 active site 1220533007910 motif 2; other site 1220533007911 motif 3; other site 1220533007912 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1220533007913 anticodon binding site; other site 1220533007914 T-box; B657_miscRNA42 1220533007915 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1220533007916 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1220533007917 Bacterial SH3 domain; Region: SH3_3; pfam08239 1220533007918 Bacterial SH3 domain; Region: SH3_3; pfam08239 1220533007919 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1220533007920 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1220533007921 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1220533007922 active site 1220533007923 metal binding site [ion binding]; metal-binding site 1220533007924 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1220533007925 dimerization interface [polypeptide binding]; other site 1220533007926 putative tRNAtyr binding site [nucleotide binding]; other site 1220533007927 putative active site [active] 1220533007928 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1220533007929 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1220533007930 Zn2+ binding site [ion binding]; other site 1220533007931 Mg2+ binding site [ion binding]; other site 1220533007932 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1220533007933 synthetase active site [active] 1220533007934 NTP binding site [chemical binding]; other site 1220533007935 metal binding site [ion binding]; metal-binding site 1220533007936 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1220533007937 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1220533007938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533007939 active site 1220533007940 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1220533007941 DHH family; Region: DHH; pfam01368 1220533007942 DHHA1 domain; Region: DHHA1; pfam02272 1220533007943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1220533007944 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1220533007945 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1220533007946 TrkA-C domain; Region: TrkA_C; pfam02080 1220533007947 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1220533007948 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1220533007949 Protein export membrane protein; Region: SecD_SecF; pfam02355 1220533007950 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1220533007951 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1220533007952 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1220533007953 Predicted membrane protein [Function unknown]; Region: COG2323 1220533007954 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1220533007955 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1220533007956 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1220533007957 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1220533007958 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1220533007959 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1220533007960 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1220533007961 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1220533007962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533007963 Walker A motif; other site 1220533007964 ATP binding site [chemical binding]; other site 1220533007965 Walker B motif; other site 1220533007966 arginine finger; other site 1220533007967 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1220533007968 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1220533007969 RuvA N terminal domain; Region: RuvA_N; pfam01330 1220533007970 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1220533007971 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1220533007972 BofC C-terminal domain; Region: BofC_C; pfam08955 1220533007973 polyol permease family; Region: 2A0118; TIGR00897 1220533007974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533007975 putative substrate translocation pore; other site 1220533007976 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1220533007977 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1220533007978 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1220533007979 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1220533007980 active site 1220533007981 substrate binding site [chemical binding]; other site 1220533007982 ATP binding site [chemical binding]; other site 1220533007983 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1220533007984 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1220533007985 hypothetical protein; Validated; Region: PRK00110 1220533007986 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1220533007987 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533007988 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1220533007989 quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550 1220533007990 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1220533007991 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1220533007992 dimerization interface [polypeptide binding]; other site 1220533007993 active site 1220533007994 L-aspartate oxidase; Provisional; Region: PRK08071 1220533007995 L-aspartate oxidase; Provisional; Region: PRK06175 1220533007996 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1220533007997 cysteine desulfurase; Provisional; Region: PRK02948 1220533007998 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1220533007999 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1220533008000 catalytic residue [active] 1220533008001 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1220533008002 HTH domain; Region: HTH_11; pfam08279 1220533008003 3H domain; Region: 3H; pfam02829 1220533008004 prephenate dehydratase; Provisional; Region: PRK11898 1220533008005 Prephenate dehydratase; Region: PDT; pfam00800 1220533008006 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1220533008007 putative L-Phe binding site [chemical binding]; other site 1220533008008 hypothetical protein; Provisional; Region: PRK04435 1220533008009 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1220533008010 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1220533008011 GTP1/OBG; Region: GTP1_OBG; pfam01018 1220533008012 Obg GTPase; Region: Obg; cd01898 1220533008013 G1 box; other site 1220533008014 GTP/Mg2+ binding site [chemical binding]; other site 1220533008015 Switch I region; other site 1220533008016 G2 box; other site 1220533008017 G3 box; other site 1220533008018 Switch II region; other site 1220533008019 G4 box; other site 1220533008020 G5 box; other site 1220533008021 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1220533008022 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1220533008023 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1220533008024 hypothetical protein; Provisional; Region: PRK14553 1220533008025 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1220533008026 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1220533008027 L21_leader; B657_miscRNA43 1220533008028 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1220533008029 active site 1220533008030 Peptidase family M50; Region: Peptidase_M50; pfam02163 1220533008031 putative substrate binding region [chemical binding]; other site 1220533008032 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1220533008033 Peptidase family M23; Region: Peptidase_M23; pfam01551 1220533008034 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1220533008035 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1220533008036 Switch I; other site 1220533008037 Switch II; other site 1220533008038 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1220533008039 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1220533008040 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1220533008041 rod shape-determining protein MreC; Region: mreC; TIGR00219 1220533008042 rod shape-determining protein MreC; Region: MreC; pfam04085 1220533008043 rod shape-determining protein MreB; Provisional; Region: PRK13927 1220533008044 MreB and similar proteins; Region: MreB_like; cd10225 1220533008045 nucleotide binding site [chemical binding]; other site 1220533008046 Mg binding site [ion binding]; other site 1220533008047 putative protofilament interaction site [polypeptide binding]; other site 1220533008048 RodZ interaction site [polypeptide binding]; other site 1220533008049 hypothetical protein; Reviewed; Region: PRK00024 1220533008050 Helix-hairpin-helix motif; Region: HHH; pfam00633 1220533008051 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1220533008052 MPN+ (JAMM) motif; other site 1220533008053 Zinc-binding site [ion binding]; other site 1220533008054 Maf-like protein; Region: Maf; pfam02545 1220533008055 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1220533008056 active site 1220533008057 dimer interface [polypeptide binding]; other site 1220533008058 Sporulation related domain; Region: SPOR; pfam05036 1220533008059 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1220533008060 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1220533008061 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1220533008062 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1220533008063 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1220533008064 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1220533008065 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1220533008066 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1220533008067 active site 1220533008068 HIGH motif; other site 1220533008069 nucleotide binding site [chemical binding]; other site 1220533008070 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1220533008071 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1220533008072 active site 1220533008073 KMSKS motif; other site 1220533008074 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1220533008075 tRNA binding surface [nucleotide binding]; other site 1220533008076 anticodon binding site; other site 1220533008077 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1220533008078 T-box; B657_miscRNA44 1220533008079 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1220533008080 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1220533008081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1220533008082 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1220533008083 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1220533008084 inhibitor-cofactor binding pocket; inhibition site 1220533008085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533008086 catalytic residue [active] 1220533008087 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1220533008088 dimer interface [polypeptide binding]; other site 1220533008089 active site 1220533008090 Schiff base residues; other site 1220533008091 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1220533008092 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1220533008093 active site 1220533008094 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1220533008095 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1220533008096 domain interfaces; other site 1220533008097 active site 1220533008098 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1220533008099 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1220533008100 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1220533008101 tRNA; other site 1220533008102 putative tRNA binding site [nucleotide binding]; other site 1220533008103 putative NADP binding site [chemical binding]; other site 1220533008104 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1220533008105 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1220533008106 G1 box; other site 1220533008107 GTP/Mg2+ binding site [chemical binding]; other site 1220533008108 Switch I region; other site 1220533008109 G2 box; other site 1220533008110 G3 box; other site 1220533008111 Switch II region; other site 1220533008112 G4 box; other site 1220533008113 G5 box; other site 1220533008114 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1220533008115 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1220533008116 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1220533008117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533008118 Walker A motif; other site 1220533008119 ATP binding site [chemical binding]; other site 1220533008120 Walker B motif; other site 1220533008121 arginine finger; other site 1220533008122 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1220533008123 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1220533008124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533008125 Walker A motif; other site 1220533008126 ATP binding site [chemical binding]; other site 1220533008127 Walker B motif; other site 1220533008128 arginine finger; other site 1220533008129 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1220533008130 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1220533008131 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1220533008132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533008133 Walker A motif; other site 1220533008134 ATP binding site [chemical binding]; other site 1220533008135 Walker B motif; other site 1220533008136 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1220533008137 trigger factor; Provisional; Region: tig; PRK01490 1220533008138 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1220533008139 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1220533008140 TPR repeat; Region: TPR_11; pfam13414 1220533008141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533008142 binding surface 1220533008143 TPR motif; other site 1220533008144 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1220533008145 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1220533008146 substrate binding site [chemical binding]; other site 1220533008147 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1220533008148 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1220533008149 substrate binding site [chemical binding]; other site 1220533008150 ligand binding site [chemical binding]; other site 1220533008151 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1220533008152 tartrate dehydrogenase; Region: TTC; TIGR02089 1220533008153 2-isopropylmalate synthase; Validated; Region: PRK00915 1220533008154 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1220533008155 active site 1220533008156 catalytic residues [active] 1220533008157 metal binding site [ion binding]; metal-binding site 1220533008158 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1220533008159 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1220533008160 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1220533008161 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1220533008162 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1220533008163 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1220533008164 putative valine binding site [chemical binding]; other site 1220533008165 dimer interface [polypeptide binding]; other site 1220533008166 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1220533008167 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1220533008168 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1220533008169 PYR/PP interface [polypeptide binding]; other site 1220533008170 dimer interface [polypeptide binding]; other site 1220533008171 TPP binding site [chemical binding]; other site 1220533008172 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1220533008173 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1220533008174 TPP-binding site [chemical binding]; other site 1220533008175 dimer interface [polypeptide binding]; other site 1220533008176 T-box; B657_miscRNA45 1220533008177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1220533008178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533008179 Coenzyme A binding pocket [chemical binding]; other site 1220533008180 Heat induced stress protein YflT; Region: YflT; pfam11181 1220533008181 conserved domain; Region: TIGR02271 1220533008182 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1220533008183 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1220533008184 active site 1220533008185 metal binding site [ion binding]; metal-binding site 1220533008186 homotetramer interface [polypeptide binding]; other site 1220533008187 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1220533008188 active site 1220533008189 dimerization interface [polypeptide binding]; other site 1220533008190 ribonuclease PH; Reviewed; Region: rph; PRK00173 1220533008191 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1220533008192 hexamer interface [polypeptide binding]; other site 1220533008193 active site 1220533008194 Spore germination protein [General function prediction only]; Region: COG5401 1220533008195 Sporulation and spore germination; Region: Germane; pfam10646 1220533008196 Sporulation and spore germination; Region: Germane; pfam10646 1220533008197 glutamate racemase; Region: glut_race; TIGR00067 1220533008198 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533008199 MarR family; Region: MarR; pfam01047 1220533008200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533008201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533008202 DNA binding residues [nucleotide binding] 1220533008203 dimerization interface [polypeptide binding]; other site 1220533008204 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1220533008205 active site 1220533008206 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1220533008207 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1220533008208 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1220533008209 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1220533008210 L-aspartate oxidase; Provisional; Region: PRK06175 1220533008211 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1220533008212 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1220533008213 putative Iron-sulfur protein interface [polypeptide binding]; other site 1220533008214 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1220533008215 proximal heme binding site [chemical binding]; other site 1220533008216 distal heme binding site [chemical binding]; other site 1220533008217 putative dimer interface [polypeptide binding]; other site 1220533008218 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1220533008219 aspartate kinase; Reviewed; Region: PRK06635 1220533008220 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1220533008221 putative nucleotide binding site [chemical binding]; other site 1220533008222 putative catalytic residues [active] 1220533008223 putative Mg ion binding site [ion binding]; other site 1220533008224 putative aspartate binding site [chemical binding]; other site 1220533008225 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1220533008226 putative allosteric regulatory site; other site 1220533008227 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1220533008228 putative allosteric regulatory residue; other site 1220533008229 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1220533008230 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1220533008231 GIY-YIG motif/motif A; other site 1220533008232 active site 1220533008233 catalytic site [active] 1220533008234 putative DNA binding site [nucleotide binding]; other site 1220533008235 metal binding site [ion binding]; metal-binding site 1220533008236 UvrB/uvrC motif; Region: UVR; pfam02151 1220533008237 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1220533008238 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1220533008239 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1220533008240 catalytic residues [active] 1220533008241 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1220533008242 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1220533008243 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1220533008244 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1220533008245 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1220533008246 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1220533008247 Ligand binding site [chemical binding]; other site 1220533008248 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1220533008249 enoyl-CoA hydratase; Provisional; Region: PRK07658 1220533008250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1220533008251 substrate binding site [chemical binding]; other site 1220533008252 oxyanion hole (OAH) forming residues; other site 1220533008253 trimer interface [polypeptide binding]; other site 1220533008254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533008255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533008256 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1220533008257 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1220533008258 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1220533008259 acyl-activating enzyme (AAE) consensus motif; other site 1220533008260 putative AMP binding site [chemical binding]; other site 1220533008261 putative active site [active] 1220533008262 putative CoA binding site [chemical binding]; other site 1220533008263 Predicted membrane protein [Function unknown]; Region: COG3766 1220533008264 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1220533008265 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1220533008266 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1220533008267 MutS domain III; Region: MutS_III; pfam05192 1220533008268 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1220533008269 Walker A/P-loop; other site 1220533008270 ATP binding site [chemical binding]; other site 1220533008271 Q-loop/lid; other site 1220533008272 ABC transporter signature motif; other site 1220533008273 Walker B; other site 1220533008274 D-loop; other site 1220533008275 H-loop/switch region; other site 1220533008276 Smr domain; Region: Smr; pfam01713 1220533008277 hypothetical protein; Provisional; Region: PRK08609 1220533008278 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1220533008279 active site 1220533008280 primer binding site [nucleotide binding]; other site 1220533008281 NTP binding site [chemical binding]; other site 1220533008282 metal binding triad [ion binding]; metal-binding site 1220533008283 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1220533008284 active site 1220533008285 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1220533008286 Colicin V production protein; Region: Colicin_V; pfam02674 1220533008287 cell division protein ZapA; Provisional; Region: PRK14126 1220533008288 ribonuclease HIII; Provisional; Region: PRK00996 1220533008289 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1220533008290 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1220533008291 RNA/DNA hybrid binding site [nucleotide binding]; other site 1220533008292 active site 1220533008293 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1220533008294 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1220533008295 putative tRNA-binding site [nucleotide binding]; other site 1220533008296 B3/4 domain; Region: B3_4; pfam03483 1220533008297 tRNA synthetase B5 domain; Region: B5; smart00874 1220533008298 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1220533008299 dimer interface [polypeptide binding]; other site 1220533008300 motif 1; other site 1220533008301 motif 3; other site 1220533008302 motif 2; other site 1220533008303 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1220533008304 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1220533008305 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1220533008306 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1220533008307 dimer interface [polypeptide binding]; other site 1220533008308 motif 1; other site 1220533008309 active site 1220533008310 motif 2; other site 1220533008311 motif 3; other site 1220533008312 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1220533008313 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1220533008314 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1220533008315 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1220533008316 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1220533008317 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1220533008318 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1220533008319 FAD binding domain; Region: FAD_binding_4; pfam01565 1220533008320 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1220533008321 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1220533008322 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1220533008323 Cysteine-rich domain; Region: CCG; pfam02754 1220533008324 Cysteine-rich domain; Region: CCG; pfam02754 1220533008325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1220533008326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533008327 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1220533008328 Carbon starvation protein CstA; Region: CstA; pfam02554 1220533008329 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1220533008330 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1220533008331 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1220533008332 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1220533008333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533008334 putative PBP binding loops; other site 1220533008335 dimer interface [polypeptide binding]; other site 1220533008336 ABC-ATPase subunit interface; other site 1220533008337 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1220533008338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533008339 dimer interface [polypeptide binding]; other site 1220533008340 conserved gate region; other site 1220533008341 putative PBP binding loops; other site 1220533008342 ABC-ATPase subunit interface; other site 1220533008343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1220533008344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1220533008345 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1220533008346 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1220533008347 active site 1220533008348 metal binding site [ion binding]; metal-binding site 1220533008349 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1220533008350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533008351 active site 1220533008352 motif I; other site 1220533008353 motif II; other site 1220533008354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533008355 motif II; other site 1220533008356 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1220533008357 L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760 1220533008358 intersubunit interface [polypeptide binding]; other site 1220533008359 active site 1220533008360 Zn2+ binding site [ion binding]; other site 1220533008361 L-ribulokinase; Region: L-ribulokinase; TIGR01234 1220533008362 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1220533008363 N- and C-terminal domain interface [polypeptide binding]; other site 1220533008364 active site 1220533008365 MgATP binding site [chemical binding]; other site 1220533008366 catalytic site [active] 1220533008367 metal binding site [ion binding]; metal-binding site 1220533008368 carbohydrate binding site [chemical binding]; other site 1220533008369 homodimer interface [polypeptide binding]; other site 1220533008370 L-arabinose isomerase; Provisional; Region: PRK02929 1220533008371 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1220533008372 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1220533008373 trimer interface [polypeptide binding]; other site 1220533008374 putative substrate binding site [chemical binding]; other site 1220533008375 putative metal binding site [ion binding]; other site 1220533008376 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1220533008377 substrate binding site [chemical binding]; other site 1220533008378 active site 1220533008379 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1220533008380 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1220533008381 oligomer interface [polypeptide binding]; other site 1220533008382 active site 1220533008383 metal binding site [ion binding]; metal-binding site 1220533008384 Predicted membrane protein [Function unknown]; Region: COG3326 1220533008385 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1220533008386 23S rRNA binding site [nucleotide binding]; other site 1220533008387 L21 binding site [polypeptide binding]; other site 1220533008388 L13 binding site [polypeptide binding]; other site 1220533008389 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1220533008390 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1220533008391 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1220533008392 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1220533008393 L20_leader; B657_miscRNA47 1220533008394 antiholin-like protein LrgB; Provisional; Region: PRK04288 1220533008395 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1220533008396 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1220533008397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533008398 active site 1220533008399 phosphorylation site [posttranslational modification] 1220533008400 intermolecular recognition site; other site 1220533008401 dimerization interface [polypeptide binding]; other site 1220533008402 LytTr DNA-binding domain; Region: LytTR; pfam04397 1220533008403 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1220533008404 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1220533008405 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1220533008406 Histidine kinase; Region: His_kinase; pfam06580 1220533008407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533008408 ATP binding site [chemical binding]; other site 1220533008409 Mg2+ binding site [ion binding]; other site 1220533008410 G-X-G motif; other site 1220533008411 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1220533008412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533008413 motif II; other site 1220533008414 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1220533008415 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1220533008416 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1220533008417 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1220533008418 active site 1220533008419 dimer interface [polypeptide binding]; other site 1220533008420 motif 1; other site 1220533008421 motif 2; other site 1220533008422 motif 3; other site 1220533008423 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1220533008424 anticodon binding site; other site 1220533008425 T-box; B657_miscRNA48 1220533008426 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 1220533008427 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1220533008428 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1220533008429 primosomal protein DnaI; Reviewed; Region: PRK08939 1220533008430 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1220533008431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533008432 Walker A motif; other site 1220533008433 ATP binding site [chemical binding]; other site 1220533008434 Walker B motif; other site 1220533008435 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1220533008436 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1220533008437 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1220533008438 ATP cone domain; Region: ATP-cone; pfam03477 1220533008439 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1220533008440 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1220533008441 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1220533008442 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1220533008443 Predicted transcriptional regulators [Transcription]; Region: COG1733 1220533008444 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1220533008445 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1220533008446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533008447 putative substrate translocation pore; other site 1220533008448 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1220533008449 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1220533008450 active site 1220533008451 catalytic tetrad [active] 1220533008452 dephospho-CoA kinase; Region: TIGR00152 1220533008453 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1220533008454 CoA-binding site [chemical binding]; other site 1220533008455 ATP-binding [chemical binding]; other site 1220533008456 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1220533008457 Domain of unknown function DUF; Region: DUF204; pfam02659 1220533008458 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1220533008459 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1220533008460 DNA binding site [nucleotide binding] 1220533008461 catalytic residue [active] 1220533008462 H2TH interface [polypeptide binding]; other site 1220533008463 putative catalytic residues [active] 1220533008464 turnover-facilitating residue; other site 1220533008465 intercalation triad [nucleotide binding]; other site 1220533008466 8OG recognition residue [nucleotide binding]; other site 1220533008467 putative reading head residues; other site 1220533008468 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1220533008469 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1220533008470 DNA polymerase I; Provisional; Region: PRK05755 1220533008471 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1220533008472 active site 1220533008473 metal binding site 1 [ion binding]; metal-binding site 1220533008474 putative 5' ssDNA interaction site; other site 1220533008475 metal binding site 3; metal-binding site 1220533008476 metal binding site 2 [ion binding]; metal-binding site 1220533008477 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1220533008478 putative DNA binding site [nucleotide binding]; other site 1220533008479 putative metal binding site [ion binding]; other site 1220533008480 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1220533008481 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1220533008482 active site 1220533008483 DNA binding site [nucleotide binding] 1220533008484 catalytic site [active] 1220533008485 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1220533008486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533008487 putative active site [active] 1220533008488 heme pocket [chemical binding]; other site 1220533008489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533008490 dimer interface [polypeptide binding]; other site 1220533008491 phosphorylation site [posttranslational modification] 1220533008492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533008493 ATP binding site [chemical binding]; other site 1220533008494 Mg2+ binding site [ion binding]; other site 1220533008495 G-X-G motif; other site 1220533008496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533008497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533008498 active site 1220533008499 phosphorylation site [posttranslational modification] 1220533008500 intermolecular recognition site; other site 1220533008501 dimerization interface [polypeptide binding]; other site 1220533008502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533008503 DNA binding site [nucleotide binding] 1220533008504 malate dehydrogenase; Reviewed; Region: PRK06223 1220533008505 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1220533008506 NAD(P) binding site [chemical binding]; other site 1220533008507 dimer interface [polypeptide binding]; other site 1220533008508 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1220533008509 substrate binding site [chemical binding]; other site 1220533008510 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1220533008511 isocitrate dehydrogenase; Validated; Region: PRK07362 1220533008512 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1220533008513 dimer interface [polypeptide binding]; other site 1220533008514 Citrate synthase; Region: Citrate_synt; pfam00285 1220533008515 active site 1220533008516 citrylCoA binding site [chemical binding]; other site 1220533008517 oxalacetate/citrate binding site [chemical binding]; other site 1220533008518 coenzyme A binding site [chemical binding]; other site 1220533008519 catalytic triad [active] 1220533008520 Predicted membrane protein [Function unknown]; Region: COG2707 1220533008521 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1220533008522 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1220533008523 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1220533008524 pyruvate kinase; Provisional; Region: PRK06354 1220533008525 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1220533008526 domain interfaces; other site 1220533008527 active site 1220533008528 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1220533008529 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1220533008530 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1220533008531 active site 1220533008532 ADP/pyrophosphate binding site [chemical binding]; other site 1220533008533 dimerization interface [polypeptide binding]; other site 1220533008534 allosteric effector site; other site 1220533008535 fructose-1,6-bisphosphate binding site; other site 1220533008536 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1220533008537 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1220533008538 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1220533008539 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1220533008540 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1220533008541 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1220533008542 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1220533008543 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1220533008544 putative NAD(P) binding site [chemical binding]; other site 1220533008545 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1220533008546 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1220533008547 active site 1220533008548 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1220533008549 generic binding surface I; other site 1220533008550 generic binding surface II; other site 1220533008551 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1220533008552 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1220533008553 DHH family; Region: DHH; pfam01368 1220533008554 DHHA1 domain; Region: DHHA1; pfam02272 1220533008555 YtpI-like protein; Region: YtpI; pfam14007 1220533008556 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1220533008557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533008558 DNA-binding site [nucleotide binding]; DNA binding site 1220533008559 DRTGG domain; Region: DRTGG; pfam07085 1220533008560 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1220533008561 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1220533008562 active site 2 [active] 1220533008563 active site 1 [active] 1220533008564 Predicted permeases [General function prediction only]; Region: COG0730 1220533008565 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1220533008566 amidohydrolase; Region: amidohydrolases; TIGR01891 1220533008567 metal binding site [ion binding]; metal-binding site 1220533008568 dimer interface [polypeptide binding]; other site 1220533008569 Riboflavin kinase; Region: Flavokinase; pfam01687 1220533008570 Riboflavin kinase; Region: Flavokinase; smart00904 1220533008571 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1220533008572 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1220533008573 active site 1220533008574 non-prolyl cis peptide bond; other site 1220533008575 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1220533008576 catalytic residues [active] 1220533008577 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1220533008578 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1220533008579 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1220533008580 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1220533008581 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1220533008582 Walker A/P-loop; other site 1220533008583 ATP binding site [chemical binding]; other site 1220533008584 Q-loop/lid; other site 1220533008585 ABC transporter signature motif; other site 1220533008586 Walker B; other site 1220533008587 D-loop; other site 1220533008588 H-loop/switch region; other site 1220533008589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533008590 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1220533008591 dimer interface [polypeptide binding]; other site 1220533008592 conserved gate region; other site 1220533008593 putative PBP binding loops; other site 1220533008594 ABC-ATPase subunit interface; other site 1220533008595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533008596 dimer interface [polypeptide binding]; other site 1220533008597 conserved gate region; other site 1220533008598 putative PBP binding loops; other site 1220533008599 ABC-ATPase subunit interface; other site 1220533008600 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1220533008601 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1220533008602 substrate binding pocket [chemical binding]; other site 1220533008603 membrane-bound complex binding site; other site 1220533008604 hinge residues; other site 1220533008605 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1220533008606 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1220533008607 substrate binding pocket [chemical binding]; other site 1220533008608 membrane-bound complex binding site; other site 1220533008609 hinge residues; other site 1220533008610 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1220533008611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533008612 Coenzyme A binding pocket [chemical binding]; other site 1220533008613 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533008614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533008615 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533008616 dimerization interface [polypeptide binding]; other site 1220533008617 metal-dependent hydrolase; Provisional; Region: PRK00685 1220533008618 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1220533008619 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1220533008620 classical (c) SDRs; Region: SDR_c; cd05233 1220533008621 NAD(P) binding site [chemical binding]; other site 1220533008622 active site 1220533008623 argininosuccinate lyase; Provisional; Region: PRK00855 1220533008624 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1220533008625 active sites [active] 1220533008626 tetramer interface [polypeptide binding]; other site 1220533008627 argininosuccinate synthase; Provisional; Region: PRK13820 1220533008628 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1220533008629 ANP binding site [chemical binding]; other site 1220533008630 Substrate Binding Site II [chemical binding]; other site 1220533008631 Substrate Binding Site I [chemical binding]; other site 1220533008632 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1220533008633 MPT binding site; other site 1220533008634 trimer interface [polypeptide binding]; other site 1220533008635 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1220533008636 propionate/acetate kinase; Provisional; Region: PRK12379 1220533008637 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1220533008638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533008639 S-adenosylmethionine binding site [chemical binding]; other site 1220533008640 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1220533008641 dimer interface [polypeptide binding]; other site 1220533008642 catalytic triad [active] 1220533008643 peroxidatic and resolving cysteines [active] 1220533008644 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1220533008645 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1220533008646 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1220533008647 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1220533008648 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1220533008649 tandem repeat interface [polypeptide binding]; other site 1220533008650 oligomer interface [polypeptide binding]; other site 1220533008651 active site residues [active] 1220533008652 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1220533008653 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1220533008654 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1220533008655 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1220533008656 active site 1220533008657 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1220533008658 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1220533008659 active site 1220533008660 acyl-activating enzyme (AAE) consensus motif; other site 1220533008661 putative CoA binding site [chemical binding]; other site 1220533008662 AMP binding site [chemical binding]; other site 1220533008663 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1220533008664 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1220533008665 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1220533008666 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1220533008667 Ligand Binding Site [chemical binding]; other site 1220533008668 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1220533008669 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1220533008670 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1220533008671 catalytic residue [active] 1220533008672 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1220533008673 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1220533008674 histidinol-phosphatase; Reviewed; Region: PRK08123 1220533008675 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1220533008676 active site 1220533008677 dimer interface [polypeptide binding]; other site 1220533008678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533008679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533008680 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1220533008681 GAF domain; Region: GAF_2; pfam13185 1220533008682 GAF domain; Region: GAF; cl17456 1220533008683 GAF domain; Region: GAF_3; pfam13492 1220533008684 GAF domain; Region: GAF_2; pfam13185 1220533008685 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1220533008686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1220533008687 metal binding site [ion binding]; metal-binding site 1220533008688 active site 1220533008689 I-site; other site 1220533008690 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1220533008691 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1220533008692 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533008693 RNA binding surface [nucleotide binding]; other site 1220533008694 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1220533008695 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1220533008696 active site 1220533008697 HIGH motif; other site 1220533008698 dimer interface [polypeptide binding]; other site 1220533008699 KMSKS motif; other site 1220533008700 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533008701 RNA binding surface [nucleotide binding]; other site 1220533008702 acetyl-CoA synthetase; Provisional; Region: PRK04319 1220533008703 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1220533008704 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1220533008705 active site 1220533008706 acyl-activating enzyme (AAE) consensus motif; other site 1220533008707 putative CoA binding site [chemical binding]; other site 1220533008708 AMP binding site [chemical binding]; other site 1220533008709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533008710 Coenzyme A binding pocket [chemical binding]; other site 1220533008711 FOG: CBS domain [General function prediction only]; Region: COG0517 1220533008712 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1220533008713 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1220533008714 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1220533008715 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1220533008716 active site 1220533008717 Zn binding site [ion binding]; other site 1220533008718 flagellar motor protein MotS; Reviewed; Region: PRK06925 1220533008719 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1220533008720 ligand binding site [chemical binding]; other site 1220533008721 flagellar motor protein MotP; Reviewed; Region: PRK06926 1220533008722 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1220533008723 catabolite control protein A; Region: ccpA; TIGR01481 1220533008724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533008725 DNA binding site [nucleotide binding] 1220533008726 domain linker motif; other site 1220533008727 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1220533008728 dimerization interface [polypeptide binding]; other site 1220533008729 effector binding site; other site 1220533008730 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1220533008731 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 1220533008732 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1220533008733 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1220533008734 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1220533008735 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1220533008736 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1220533008737 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1220533008738 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1220533008739 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1220533008740 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1220533008741 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1220533008742 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1220533008743 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1220533008744 putative tRNA-binding site [nucleotide binding]; other site 1220533008745 hypothetical protein; Provisional; Region: PRK13668 1220533008746 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1220533008747 catalytic residues [active] 1220533008748 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1220533008749 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1220533008750 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1220533008751 oligomer interface [polypeptide binding]; other site 1220533008752 active site 1220533008753 metal binding site [ion binding]; metal-binding site 1220533008754 Predicted small secreted protein [Function unknown]; Region: COG5584 1220533008755 malate dehydrogenase; Provisional; Region: PRK13529 1220533008756 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1220533008757 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1220533008758 NAD(P) binding site [chemical binding]; other site 1220533008759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1220533008760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533008761 S-adenosylmethionine binding site [chemical binding]; other site 1220533008762 YtzH-like protein; Region: YtzH; pfam14165 1220533008763 Phosphotransferase enzyme family; Region: APH; pfam01636 1220533008764 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1220533008765 substrate binding site [chemical binding]; other site 1220533008766 pullulanase, type I; Region: pulA_typeI; TIGR02104 1220533008767 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1220533008768 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1220533008769 Ca binding site [ion binding]; other site 1220533008770 active site 1220533008771 catalytic site [active] 1220533008772 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1220533008773 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1220533008774 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1220533008775 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1220533008776 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1220533008777 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1220533008778 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1220533008779 dimer interface [polypeptide binding]; other site 1220533008780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533008781 catalytic residue [active] 1220533008782 dipeptidase PepV; Reviewed; Region: PRK07318 1220533008783 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1220533008784 active site 1220533008785 metal binding site [ion binding]; metal-binding site 1220533008786 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1220533008787 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1220533008788 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1220533008789 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1220533008790 Walker A/P-loop; other site 1220533008791 ATP binding site [chemical binding]; other site 1220533008792 Q-loop/lid; other site 1220533008793 ABC transporter signature motif; other site 1220533008794 Walker B; other site 1220533008795 D-loop; other site 1220533008796 H-loop/switch region; other site 1220533008797 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1220533008798 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1220533008799 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1220533008800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533008801 RNA binding surface [nucleotide binding]; other site 1220533008802 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1220533008803 active site 1220533008804 uracil binding [chemical binding]; other site 1220533008805 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1220533008806 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1220533008807 Predicted flavoproteins [General function prediction only]; Region: COG2081 1220533008808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1220533008809 BCCT family transporter; Region: BCCT; pfam02028 1220533008810 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1220533008811 Predicted integral membrane protein [Function unknown]; Region: COG5578 1220533008812 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1220533008813 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1220533008814 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1220533008815 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1220533008816 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1220533008817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533008818 dimer interface [polypeptide binding]; other site 1220533008819 conserved gate region; other site 1220533008820 ABC-ATPase subunit interface; other site 1220533008821 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1220533008822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533008823 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1220533008824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1220533008825 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1220533008826 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1220533008827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533008828 dimer interface [polypeptide binding]; other site 1220533008829 conserved gate region; other site 1220533008830 putative PBP binding loops; other site 1220533008831 ABC-ATPase subunit interface; other site 1220533008832 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1220533008833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1220533008834 NAD(P) binding site [chemical binding]; other site 1220533008835 active site 1220533008836 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1220533008837 Cytochrome P450; Region: p450; cl12078 1220533008838 biotin synthase; Validated; Region: PRK06256 1220533008839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533008840 FeS/SAM binding site; other site 1220533008841 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1220533008842 AAA domain; Region: AAA_26; pfam13500 1220533008843 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1220533008844 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1220533008845 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1220533008846 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1220533008847 substrate-cofactor binding pocket; other site 1220533008848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533008849 catalytic residue [active] 1220533008850 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1220533008851 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1220533008852 inhibitor-cofactor binding pocket; inhibition site 1220533008853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533008854 catalytic residue [active] 1220533008855 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1220533008856 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1220533008857 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1220533008858 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1220533008859 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533008860 DNA binding site [nucleotide binding] 1220533008861 domain linker motif; other site 1220533008862 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1220533008863 putative ligand binding site [chemical binding]; other site 1220533008864 putative dimerization interface [polypeptide binding]; other site 1220533008865 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1220533008866 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1220533008867 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1220533008868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533008869 dimer interface [polypeptide binding]; other site 1220533008870 conserved gate region; other site 1220533008871 putative PBP binding loops; other site 1220533008872 ABC-ATPase subunit interface; other site 1220533008873 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1220533008874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533008875 dimer interface [polypeptide binding]; other site 1220533008876 conserved gate region; other site 1220533008877 putative PBP binding loops; other site 1220533008878 ABC-ATPase subunit interface; other site 1220533008879 alpha-galactosidase; Provisional; Region: PRK15076 1220533008880 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1220533008881 NAD binding site [chemical binding]; other site 1220533008882 sugar binding site [chemical binding]; other site 1220533008883 divalent metal binding site [ion binding]; other site 1220533008884 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1220533008885 dimer interface [polypeptide binding]; other site 1220533008886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1220533008887 active site residue [active] 1220533008888 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1220533008889 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1220533008890 HIGH motif; other site 1220533008891 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1220533008892 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1220533008893 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1220533008894 active site 1220533008895 KMSKS motif; other site 1220533008896 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1220533008897 tRNA binding surface [nucleotide binding]; other site 1220533008898 T-box; B657_miscRNA49 1220533008899 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1220533008900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533008901 PAS domain; Region: PAS_9; pfam13426 1220533008902 putative active site [active] 1220533008903 heme pocket [chemical binding]; other site 1220533008904 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1220533008905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533008906 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533008907 putative substrate translocation pore; other site 1220533008908 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1220533008909 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1220533008910 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1220533008911 FtsX-like permease family; Region: FtsX; pfam02687 1220533008912 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1220533008913 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1220533008914 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1220533008915 Walker A/P-loop; other site 1220533008916 ATP binding site [chemical binding]; other site 1220533008917 Q-loop/lid; other site 1220533008918 ABC transporter signature motif; other site 1220533008919 Walker B; other site 1220533008920 D-loop; other site 1220533008921 H-loop/switch region; other site 1220533008922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533008923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533008924 ATP binding site [chemical binding]; other site 1220533008925 Mg2+ binding site [ion binding]; other site 1220533008926 G-X-G motif; other site 1220533008927 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533008928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533008929 active site 1220533008930 phosphorylation site [posttranslational modification] 1220533008931 intermolecular recognition site; other site 1220533008932 dimerization interface [polypeptide binding]; other site 1220533008933 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533008934 DNA binding site [nucleotide binding] 1220533008935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1220533008936 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1220533008937 FtsX-like permease family; Region: FtsX; pfam02687 1220533008938 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1220533008939 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1220533008940 Walker A/P-loop; other site 1220533008941 ATP binding site [chemical binding]; other site 1220533008942 Q-loop/lid; other site 1220533008943 ABC transporter signature motif; other site 1220533008944 Walker B; other site 1220533008945 D-loop; other site 1220533008946 H-loop/switch region; other site 1220533008947 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1220533008948 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1220533008949 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1220533008950 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1220533008951 Walker A/P-loop; other site 1220533008952 ATP binding site [chemical binding]; other site 1220533008953 Q-loop/lid; other site 1220533008954 ABC transporter signature motif; other site 1220533008955 Walker B; other site 1220533008956 D-loop; other site 1220533008957 H-loop/switch region; other site 1220533008958 Predicted transcriptional regulators [Transcription]; Region: COG1725 1220533008959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533008960 DNA-binding site [nucleotide binding]; DNA binding site 1220533008961 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1220533008962 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1220533008963 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1220533008964 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1220533008965 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1220533008966 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1220533008967 PGAP1-like protein; Region: PGAP1; pfam07819 1220533008968 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1220533008969 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1220533008970 trimer interface [polypeptide binding]; other site 1220533008971 putative metal binding site [ion binding]; other site 1220533008972 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1220533008973 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1220533008974 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1220533008975 active site 1220533008976 dimer interface [polypeptide binding]; other site 1220533008977 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1220533008978 Ligand Binding Site [chemical binding]; other site 1220533008979 Molecular Tunnel; other site 1220533008980 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1220533008981 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1220533008982 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1220533008983 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1220533008984 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1220533008985 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1220533008986 active site 1220533008987 substrate-binding site [chemical binding]; other site 1220533008988 metal-binding site [ion binding] 1220533008989 ATP binding site [chemical binding]; other site 1220533008990 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1220533008991 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1220533008992 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1220533008993 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1220533008994 NMT1-like family; Region: NMT1_2; pfam13379 1220533008995 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1220533008996 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1220533008997 Walker A/P-loop; other site 1220533008998 ATP binding site [chemical binding]; other site 1220533008999 Q-loop/lid; other site 1220533009000 ABC transporter signature motif; other site 1220533009001 Walker B; other site 1220533009002 D-loop; other site 1220533009003 H-loop/switch region; other site 1220533009004 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1220533009005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533009006 dimer interface [polypeptide binding]; other site 1220533009007 conserved gate region; other site 1220533009008 putative PBP binding loops; other site 1220533009009 ABC-ATPase subunit interface; other site 1220533009010 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1220533009011 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1220533009012 nudix motif; other site 1220533009013 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1220533009014 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1220533009015 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1220533009016 dimerization interface [polypeptide binding]; other site 1220533009017 DPS ferroxidase diiron center [ion binding]; other site 1220533009018 ion pore; other site 1220533009019 YtkA-like; Region: YtkA; pfam13115 1220533009020 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 1220533009021 Haemolytic domain; Region: Haemolytic; pfam01809 1220533009022 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1220533009023 active site clefts [active] 1220533009024 zinc binding site [ion binding]; other site 1220533009025 dimer interface [polypeptide binding]; other site 1220533009026 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1220533009027 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1220533009028 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1220533009029 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1220533009030 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1220533009031 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533009032 ABC-ATPase subunit interface; other site 1220533009033 dimer interface [polypeptide binding]; other site 1220533009034 putative PBP binding regions; other site 1220533009035 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1220533009036 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533009037 ABC-ATPase subunit interface; other site 1220533009038 dimer interface [polypeptide binding]; other site 1220533009039 putative PBP binding regions; other site 1220533009040 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1220533009041 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1220533009042 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1220533009043 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1220533009044 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1220533009045 metal binding site [ion binding]; metal-binding site 1220533009046 intersubunit interface [polypeptide binding]; other site 1220533009047 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1220533009048 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1220533009049 active site 1220533009050 octamer interface [polypeptide binding]; other site 1220533009051 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1220533009052 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1220533009053 acyl-activating enzyme (AAE) consensus motif; other site 1220533009054 putative AMP binding site [chemical binding]; other site 1220533009055 putative active site [active] 1220533009056 putative CoA binding site [chemical binding]; other site 1220533009057 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1220533009058 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1220533009059 substrate binding site [chemical binding]; other site 1220533009060 oxyanion hole (OAH) forming residues; other site 1220533009061 trimer interface [polypeptide binding]; other site 1220533009062 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1220533009063 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1220533009064 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1220533009065 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1220533009066 dimer interface [polypeptide binding]; other site 1220533009067 tetramer interface [polypeptide binding]; other site 1220533009068 PYR/PP interface [polypeptide binding]; other site 1220533009069 TPP binding site [chemical binding]; other site 1220533009070 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1220533009071 TPP-binding site; other site 1220533009072 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1220533009073 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1220533009074 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1220533009075 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1220533009076 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1220533009077 active site 1220533009078 tetramer interface; other site 1220533009079 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1220533009080 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1220533009081 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1220533009082 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1220533009083 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1220533009084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1220533009085 NAD(P) binding site [chemical binding]; other site 1220533009086 active site 1220533009087 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1220533009088 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1220533009089 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1220533009090 spore coat protein YutH; Region: spore_yutH; TIGR02905 1220533009091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1220533009092 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1220533009093 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1220533009094 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1220533009095 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1220533009096 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1220533009097 homodimer interface [polypeptide binding]; other site 1220533009098 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1220533009099 active site pocket [active] 1220533009100 glycogen synthase; Provisional; Region: glgA; PRK00654 1220533009101 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1220533009102 ADP-binding pocket [chemical binding]; other site 1220533009103 homodimer interface [polypeptide binding]; other site 1220533009104 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1220533009105 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1220533009106 ligand binding site; other site 1220533009107 oligomer interface; other site 1220533009108 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1220533009109 dimer interface [polypeptide binding]; other site 1220533009110 N-terminal domain interface [polypeptide binding]; other site 1220533009111 sulfate 1 binding site; other site 1220533009112 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1220533009113 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1220533009114 ligand binding site; other site 1220533009115 oligomer interface; other site 1220533009116 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1220533009117 dimer interface [polypeptide binding]; other site 1220533009118 N-terminal domain interface [polypeptide binding]; other site 1220533009119 sulfate 1 binding site; other site 1220533009120 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 1220533009121 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1220533009122 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1220533009123 active site 1220533009124 catalytic site [active] 1220533009125 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1220533009126 Predicted membrane protein [Function unknown]; Region: COG3859 1220533009127 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1220533009128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533009129 Coenzyme A binding pocket [chemical binding]; other site 1220533009130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1220533009131 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1220533009132 DinB superfamily; Region: DinB_2; pfam12867 1220533009133 MOSC domain; Region: MOSC; pfam03473 1220533009134 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1220533009135 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1220533009136 active site 1220533009137 NAD binding site [chemical binding]; other site 1220533009138 metal binding site [ion binding]; metal-binding site 1220533009139 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1220533009140 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1220533009141 tetramerization interface [polypeptide binding]; other site 1220533009142 NAD(P) binding site [chemical binding]; other site 1220533009143 catalytic residues [active] 1220533009144 Predicted transcriptional regulators [Transcription]; Region: COG1510 1220533009145 MarR family; Region: MarR_2; pfam12802 1220533009146 ydaO-yuaA; B657_miscRNA52 1220533009147 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1220533009148 TrkA-N domain; Region: TrkA_N; pfam02254 1220533009149 TrkA-C domain; Region: TrkA_C; pfam02080 1220533009150 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1220533009151 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1220533009152 Predicted membrane protein [Function unknown]; Region: COG4682 1220533009153 yiaA/B two helix domain; Region: YiaAB; pfam05360 1220533009154 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1220533009155 SH3-like domain; Region: SH3_8; pfam13457 1220533009156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533009157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533009158 putative substrate translocation pore; other site 1220533009159 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1220533009160 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1220533009161 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1220533009162 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1220533009163 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1220533009164 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1220533009165 L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134 1220533009166 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1220533009167 Domain of unknown function (DUF718); Region: DUF718; cl01281 1220533009168 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1220533009169 N- and C-terminal domain interface [polypeptide binding]; other site 1220533009170 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1220533009171 active site 1220533009172 putative catalytic site [active] 1220533009173 metal binding site [ion binding]; metal-binding site 1220533009174 ATP binding site [chemical binding]; other site 1220533009175 carbohydrate binding site [chemical binding]; other site 1220533009176 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1220533009177 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1220533009178 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1220533009179 short chain dehydrogenase; Validated; Region: PRK08324 1220533009180 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1220533009181 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1220533009182 putative NAD(P) binding site [chemical binding]; other site 1220533009183 active site 1220533009184 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1220533009185 Cache domain; Region: Cache_1; pfam02743 1220533009186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533009187 dimerization interface [polypeptide binding]; other site 1220533009188 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1220533009189 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533009190 dimer interface [polypeptide binding]; other site 1220533009191 putative CheW interface [polypeptide binding]; other site 1220533009192 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533009193 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1220533009194 Cache domain; Region: Cache_1; pfam02743 1220533009195 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533009196 dimerization interface [polypeptide binding]; other site 1220533009197 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533009198 dimer interface [polypeptide binding]; other site 1220533009199 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1220533009200 putative CheW interface [polypeptide binding]; other site 1220533009201 Tar ligand binding domain homologue; Region: TarH; pfam02203 1220533009202 Cache domain; Region: Cache_1; pfam02743 1220533009203 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1220533009204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533009205 dimerization interface [polypeptide binding]; other site 1220533009206 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533009207 dimer interface [polypeptide binding]; other site 1220533009208 putative CheW interface [polypeptide binding]; other site 1220533009209 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1220533009210 Cache domain; Region: Cache_1; pfam02743 1220533009211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533009212 dimerization interface [polypeptide binding]; other site 1220533009213 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1220533009214 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533009215 dimer interface [polypeptide binding]; other site 1220533009216 putative CheW interface [polypeptide binding]; other site 1220533009217 transglutaminase; Provisional; Region: tgl; PRK03187 1220533009218 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1220533009219 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1220533009220 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1220533009221 Ca binding site [ion binding]; other site 1220533009222 active site 1220533009223 catalytic site [active] 1220533009224 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1220533009225 Domain of unknown function DUF21; Region: DUF21; pfam01595 1220533009226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1220533009227 Transporter associated domain; Region: CorC_HlyC; smart01091 1220533009228 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1220533009229 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1220533009230 Ion channel; Region: Ion_trans_2; pfam07885 1220533009231 TrkA-N domain; Region: TrkA_N; pfam02254 1220533009232 YugN-like family; Region: YugN; pfam08868 1220533009233 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1220533009234 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1220533009235 active site 1220533009236 dimer interface [polypeptide binding]; other site 1220533009237 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1220533009238 dimer interface [polypeptide binding]; other site 1220533009239 active site 1220533009240 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1220533009241 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1220533009242 dimer interface [polypeptide binding]; other site 1220533009243 active site 1220533009244 metal binding site [ion binding]; metal-binding site 1220533009245 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1220533009246 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1220533009247 dimer interface [polypeptide binding]; other site 1220533009248 active site 1220533009249 metal binding site [ion binding]; metal-binding site 1220533009250 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1220533009251 general stress protein 13; Validated; Region: PRK08059 1220533009252 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1220533009253 RNA binding site [nucleotide binding]; other site 1220533009254 hypothetical protein; Validated; Region: PRK07682 1220533009255 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533009256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533009257 homodimer interface [polypeptide binding]; other site 1220533009258 catalytic residue [active] 1220533009259 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1220533009260 AsnC family; Region: AsnC_trans_reg; pfam01037 1220533009261 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533009262 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1220533009263 nucleophilic elbow; other site 1220533009264 catalytic triad; other site 1220533009265 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1220533009266 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1220533009267 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533009268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533009269 homodimer interface [polypeptide binding]; other site 1220533009270 catalytic residue [active] 1220533009271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533009272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533009273 dimer interface [polypeptide binding]; other site 1220533009274 phosphorylation site [posttranslational modification] 1220533009275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533009276 ATP binding site [chemical binding]; other site 1220533009277 Mg2+ binding site [ion binding]; other site 1220533009278 G-X-G motif; other site 1220533009279 Kinase associated protein B; Region: KapB; pfam08810 1220533009280 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1220533009281 active site 1220533009282 catalytic site [active] 1220533009283 substrate binding site [chemical binding]; other site 1220533009284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533009285 drug efflux system protein MdtG; Provisional; Region: PRK09874 1220533009286 putative substrate translocation pore; other site 1220533009287 Transglycosylase; Region: Transgly; pfam00912 1220533009288 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1220533009289 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1220533009290 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1220533009291 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1220533009292 PAS domain; Region: PAS; smart00091 1220533009293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533009294 ATP binding site [chemical binding]; other site 1220533009295 G-X-G motif; other site 1220533009296 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1220533009297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533009298 active site 1220533009299 phosphorylation site [posttranslational modification] 1220533009300 intermolecular recognition site; other site 1220533009301 dimerization interface [polypeptide binding]; other site 1220533009302 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1220533009303 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1220533009304 ligand binding site [chemical binding]; other site 1220533009305 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1220533009306 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1220533009307 Walker A/P-loop; other site 1220533009308 ATP binding site [chemical binding]; other site 1220533009309 Q-loop/lid; other site 1220533009310 ABC transporter signature motif; other site 1220533009311 Walker B; other site 1220533009312 D-loop; other site 1220533009313 H-loop/switch region; other site 1220533009314 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1220533009315 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1220533009316 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1220533009317 TM-ABC transporter signature motif; other site 1220533009318 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1220533009319 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1220533009320 TM-ABC transporter signature motif; other site 1220533009321 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1220533009322 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1220533009323 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1220533009324 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1220533009325 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1220533009326 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1220533009327 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1220533009328 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1220533009329 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1220533009330 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1220533009331 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1220533009332 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1220533009333 CoenzymeA binding site [chemical binding]; other site 1220533009334 subunit interaction site [polypeptide binding]; other site 1220533009335 PHB binding site; other site 1220533009336 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533009337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533009338 active site 1220533009339 phosphorylation site [posttranslational modification] 1220533009340 intermolecular recognition site; other site 1220533009341 dimerization interface [polypeptide binding]; other site 1220533009342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533009343 DNA binding residues [nucleotide binding] 1220533009344 dimerization interface [polypeptide binding]; other site 1220533009345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1220533009346 Histidine kinase; Region: HisKA_3; pfam07730 1220533009347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533009348 ATP binding site [chemical binding]; other site 1220533009349 Mg2+ binding site [ion binding]; other site 1220533009350 G-X-G motif; other site 1220533009351 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1220533009352 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1220533009353 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1220533009354 substrate binding pocket [chemical binding]; other site 1220533009355 substrate-Mg2+ binding site; other site 1220533009356 aspartate-rich region 1; other site 1220533009357 DegQ (SacQ) family; Region: DegQ; pfam08181 1220533009358 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1220533009359 EAL domain; Region: EAL; pfam00563 1220533009360 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1220533009361 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1220533009362 active site 1220533009363 Isochorismatase family; Region: Isochorismatase; pfam00857 1220533009364 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1220533009365 catalytic triad [active] 1220533009366 conserved cis-peptide bond; other site 1220533009367 Uncharacterized conserved protein [Function unknown]; Region: COG5506 1220533009368 YueH-like protein; Region: YueH; pfam14166 1220533009369 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1220533009370 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1220533009371 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1220533009372 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 1220533009373 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1220533009374 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1220533009375 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1220533009376 Zn2+ binding site [ion binding]; other site 1220533009377 Mg2+ binding site [ion binding]; other site 1220533009378 short chain dehydrogenase; Provisional; Region: PRK06924 1220533009379 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1220533009380 NADP binding site [chemical binding]; other site 1220533009381 homodimer interface [polypeptide binding]; other site 1220533009382 active site 1220533009383 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1220533009384 Predicted membrane protein [Function unknown]; Region: COG1511 1220533009385 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1220533009386 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1220533009387 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1220533009388 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1220533009389 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1220533009390 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1220533009391 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1220533009392 Domain of unknown function DUF87; Region: DUF87; pfam01935 1220533009393 Predicted membrane protein [Function unknown]; Region: COG4499 1220533009394 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1220533009395 Uncharacterized small protein [Function unknown]; Region: COG5417 1220533009396 Ubiquitin homologues; Region: UBQ; smart00213 1220533009397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1220533009398 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1220533009399 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1220533009400 alanine dehydrogenase; Region: alaDH; TIGR00518 1220533009401 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1220533009402 hexamer interface [polypeptide binding]; other site 1220533009403 ligand binding site [chemical binding]; other site 1220533009404 putative active site [active] 1220533009405 NAD(P) binding site [chemical binding]; other site 1220533009406 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1220533009407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1220533009408 Condensation domain; Region: Condensation; pfam00668 1220533009409 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1220533009410 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1220533009411 acyl-activating enzyme (AAE) consensus motif; other site 1220533009412 AMP binding site [chemical binding]; other site 1220533009413 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533009414 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1220533009415 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1220533009416 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1220533009417 acyl-activating enzyme (AAE) consensus motif; other site 1220533009418 AMP binding site [chemical binding]; other site 1220533009419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1220533009420 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1220533009421 hydrophobic substrate binding pocket; other site 1220533009422 Isochorismatase family; Region: Isochorismatase; pfam00857 1220533009423 active site 1220533009424 conserved cis-peptide bond; other site 1220533009425 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1220533009426 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1220533009427 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1220533009428 acyl-activating enzyme (AAE) consensus motif; other site 1220533009429 active site 1220533009430 AMP binding site [chemical binding]; other site 1220533009431 substrate binding site [chemical binding]; other site 1220533009432 isochorismate synthase DhbC; Validated; Region: PRK06923 1220533009433 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1220533009434 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1220533009435 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1220533009436 putative NAD(P) binding site [chemical binding]; other site 1220533009437 active site 1220533009438 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1220533009439 Putative esterase; Region: Esterase; pfam00756 1220533009440 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1220533009441 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1220533009442 Moco binding site; other site 1220533009443 metal coordination site [ion binding]; other site 1220533009444 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1220533009445 Predicted permease [General function prediction only]; Region: COG2056 1220533009446 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1220533009447 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1220533009448 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1220533009449 interface (dimer of trimers) [polypeptide binding]; other site 1220533009450 Substrate-binding/catalytic site; other site 1220533009451 Zn-binding sites [ion binding]; other site 1220533009452 Divergent PAP2 family; Region: DUF212; pfam02681 1220533009453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1220533009454 Putative membrane protein; Region: YuiB; pfam14068 1220533009455 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1220533009456 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1220533009457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533009458 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1220533009459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1220533009460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533009461 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1220533009462 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1220533009463 active site 1220533009464 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1220533009465 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1220533009466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533009467 Coenzyme A binding pocket [chemical binding]; other site 1220533009468 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1220533009469 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1220533009470 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1220533009471 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1220533009472 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1220533009473 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1220533009474 Nucleoside recognition; Region: Gate; pfam07670 1220533009475 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1220533009476 hypothetical protein; Provisional; Region: PRK13669 1220533009477 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1220533009478 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533009479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1220533009480 NifU-like domain; Region: NifU; pfam01106 1220533009481 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1220533009482 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1220533009483 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1220533009484 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1220533009485 homoserine kinase; Region: thrB; TIGR00191 1220533009486 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1220533009487 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1220533009488 threonine synthase; Reviewed; Region: PRK06721 1220533009489 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1220533009490 homodimer interface [polypeptide binding]; other site 1220533009491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533009492 catalytic residue [active] 1220533009493 homoserine dehydrogenase; Provisional; Region: PRK06349 1220533009494 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1220533009495 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1220533009496 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1220533009497 spore coat protein YutH; Region: spore_yutH; TIGR02905 1220533009498 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1220533009499 tetramer interfaces [polypeptide binding]; other site 1220533009500 binuclear metal-binding site [ion binding]; other site 1220533009501 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1220533009502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533009503 active site 1220533009504 motif I; other site 1220533009505 motif II; other site 1220533009506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533009507 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1220533009508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1220533009509 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1220533009510 lipoyl synthase; Provisional; Region: PRK05481 1220533009511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533009512 FeS/SAM binding site; other site 1220533009513 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1220533009514 Peptidase family M23; Region: Peptidase_M23; pfam01551 1220533009515 sporulation protein YunB; Region: spo_yunB; TIGR02832 1220533009516 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1220533009517 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1220533009518 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1220533009519 active site 1220533009520 metal binding site [ion binding]; metal-binding site 1220533009521 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1220533009522 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1220533009523 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1220533009524 allantoinase; Provisional; Region: PRK06189 1220533009525 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1220533009526 active site 1220533009527 DRTGG domain; Region: DRTGG; pfam07085 1220533009528 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1220533009529 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1220533009530 xanthine permease; Region: pbuX; TIGR03173 1220533009531 xanthine permease; Region: pbuX; TIGR03173 1220533009532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1220533009533 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1220533009534 Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the...; Region: Uricase; cd00445 1220533009535 tetramer interface [polypeptide binding]; other site 1220533009536 active site 1220533009537 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cd05469 1220533009538 active site 1220533009539 homotetramer interface [polypeptide binding]; other site 1220533009540 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1220533009541 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1220533009542 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1220533009543 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1220533009544 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1220533009545 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1220533009546 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1220533009547 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1220533009548 Ligand binding site; other site 1220533009549 metal-binding site 1220533009550 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1220533009551 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1220533009552 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1220533009553 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1220533009554 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1220533009555 catalytic residue [active] 1220533009556 allantoate amidohydrolase; Reviewed; Region: PRK09290 1220533009557 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1220533009558 active site 1220533009559 metal binding site [ion binding]; metal-binding site 1220533009560 dimer interface [polypeptide binding]; other site 1220533009561 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1220533009562 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1220533009563 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1220533009564 Walker A/P-loop; other site 1220533009565 ATP binding site [chemical binding]; other site 1220533009566 Q-loop/lid; other site 1220533009567 ABC transporter signature motif; other site 1220533009568 Walker B; other site 1220533009569 D-loop; other site 1220533009570 H-loop/switch region; other site 1220533009571 TOBE domain; Region: TOBE_2; pfam08402 1220533009572 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1220533009573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533009574 DNA-binding site [nucleotide binding]; DNA binding site 1220533009575 UTRA domain; Region: UTRA; pfam07702 1220533009576 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1220533009577 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1220533009578 substrate binding site [chemical binding]; other site 1220533009579 ATP binding site [chemical binding]; other site 1220533009580 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1220533009581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533009582 dimer interface [polypeptide binding]; other site 1220533009583 conserved gate region; other site 1220533009584 putative PBP binding loops; other site 1220533009585 ABC-ATPase subunit interface; other site 1220533009586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533009587 dimer interface [polypeptide binding]; other site 1220533009588 conserved gate region; other site 1220533009589 putative PBP binding loops; other site 1220533009590 ABC-ATPase subunit interface; other site 1220533009591 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1220533009592 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1220533009593 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1220533009594 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1220533009595 putative active site [active] 1220533009596 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1220533009597 dimer interface [polypeptide binding]; other site 1220533009598 active site 1220533009599 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1220533009600 GIY-YIG motif/motif A; other site 1220533009601 active site 1220533009602 catalytic site [active] 1220533009603 putative DNA binding site [nucleotide binding]; other site 1220533009604 metal binding site [ion binding]; metal-binding site 1220533009605 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1220533009606 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1220533009607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533009608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1220533009609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533009610 dimerization interface [polypeptide binding]; other site 1220533009611 putative DNA binding site [nucleotide binding]; other site 1220533009612 putative Zn2+ binding site [ion binding]; other site 1220533009613 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1220533009614 FeS assembly protein SufB; Region: sufB; TIGR01980 1220533009615 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1220533009616 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1220533009617 trimerization site [polypeptide binding]; other site 1220533009618 active site 1220533009619 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1220533009620 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1220533009621 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1220533009622 catalytic residue [active] 1220533009623 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1220533009624 FeS assembly protein SufD; Region: sufD; TIGR01981 1220533009625 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1220533009626 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1220533009627 Walker A/P-loop; other site 1220533009628 ATP binding site [chemical binding]; other site 1220533009629 Q-loop/lid; other site 1220533009630 ABC transporter signature motif; other site 1220533009631 Walker B; other site 1220533009632 D-loop; other site 1220533009633 H-loop/switch region; other site 1220533009634 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1220533009635 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1220533009636 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1220533009637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533009638 conserved gate region; other site 1220533009639 ABC-ATPase subunit interface; other site 1220533009640 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1220533009641 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1220533009642 Walker A/P-loop; other site 1220533009643 ATP binding site [chemical binding]; other site 1220533009644 Q-loop/lid; other site 1220533009645 ABC transporter signature motif; other site 1220533009646 Walker B; other site 1220533009647 D-loop; other site 1220533009648 H-loop/switch region; other site 1220533009649 NIL domain; Region: NIL; pfam09383 1220533009650 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1220533009651 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1220533009652 catalytic residues [active] 1220533009653 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1220533009654 putative active site [active] 1220533009655 putative metal binding site [ion binding]; other site 1220533009656 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1220533009657 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1220533009658 lipoyl attachment site [posttranslational modification]; other site 1220533009659 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1220533009660 ArsC family; Region: ArsC; pfam03960 1220533009661 putative ArsC-like catalytic residues; other site 1220533009662 putative TRX-like catalytic residues [active] 1220533009663 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1220533009664 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1220533009665 active site 1220533009666 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1220533009667 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1220533009668 dimer interface [polypeptide binding]; other site 1220533009669 active site 1220533009670 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1220533009671 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1220533009672 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1220533009673 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1220533009674 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1220533009675 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1220533009676 substrate binding site [chemical binding]; other site 1220533009677 oxyanion hole (OAH) forming residues; other site 1220533009678 trimer interface [polypeptide binding]; other site 1220533009679 Proline dehydrogenase; Region: Pro_dh; pfam01619 1220533009680 Coat F domain; Region: Coat_F; pfam07875 1220533009681 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533009682 MarR family; Region: MarR; pfam01047 1220533009683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533009684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533009685 putative substrate translocation pore; other site 1220533009686 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1220533009687 classical (c) SDRs; Region: SDR_c; cd05233 1220533009688 active site 1220533009689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1220533009690 NAD(P) binding site [chemical binding]; other site 1220533009691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533009692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533009693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1220533009694 dimerization interface [polypeptide binding]; other site 1220533009695 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1220533009696 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1220533009697 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1220533009698 Walker A/P-loop; other site 1220533009699 ATP binding site [chemical binding]; other site 1220533009700 Q-loop/lid; other site 1220533009701 ABC transporter signature motif; other site 1220533009702 Walker B; other site 1220533009703 D-loop; other site 1220533009704 H-loop/switch region; other site 1220533009705 YusW-like protein; Region: YusW; pfam14039 1220533009706 short chain dehydrogenase; Provisional; Region: PRK06914 1220533009707 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1220533009708 NADP binding site [chemical binding]; other site 1220533009709 active site 1220533009710 steroid binding site; other site 1220533009711 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1220533009712 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1220533009713 dimerization interface [polypeptide binding]; other site 1220533009714 DPS ferroxidase diiron center [ion binding]; other site 1220533009715 ion pore; other site 1220533009716 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1220533009717 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1220533009718 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1220533009719 protein binding site [polypeptide binding]; other site 1220533009720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533009721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533009722 active site 1220533009723 phosphorylation site [posttranslational modification] 1220533009724 intermolecular recognition site; other site 1220533009725 dimerization interface [polypeptide binding]; other site 1220533009726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533009727 DNA binding site [nucleotide binding] 1220533009728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533009729 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533009730 dimerization interface [polypeptide binding]; other site 1220533009731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533009732 dimer interface [polypeptide binding]; other site 1220533009733 phosphorylation site [posttranslational modification] 1220533009734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533009735 ATP binding site [chemical binding]; other site 1220533009736 Mg2+ binding site [ion binding]; other site 1220533009737 G-X-G motif; other site 1220533009738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533009739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533009740 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1220533009741 Class II fumarases; Region: Fumarase_classII; cd01362 1220533009742 active site 1220533009743 tetramer interface [polypeptide binding]; other site 1220533009744 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1220533009745 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1220533009746 Spore germination protein; Region: Spore_permease; pfam03845 1220533009747 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1220533009748 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1220533009749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533009750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533009751 active site 1220533009752 phosphorylation site [posttranslational modification] 1220533009753 intermolecular recognition site; other site 1220533009754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533009755 DNA binding residues [nucleotide binding] 1220533009756 dimerization interface [polypeptide binding]; other site 1220533009757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1220533009758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533009759 dimerization interface [polypeptide binding]; other site 1220533009760 Histidine kinase; Region: HisKA_3; pfam07730 1220533009761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533009762 ATP binding site [chemical binding]; other site 1220533009763 Mg2+ binding site [ion binding]; other site 1220533009764 G-X-G motif; other site 1220533009765 Predicted membrane protein [Function unknown]; Region: COG4758 1220533009766 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1220533009767 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1220533009768 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1220533009769 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1220533009770 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1220533009771 PspA/IM30 family; Region: PspA_IM30; pfam04012 1220533009772 H+ Antiporter protein; Region: 2A0121; TIGR00900 1220533009773 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 1220533009774 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1220533009775 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1220533009776 Walker A/P-loop; other site 1220533009777 ATP binding site [chemical binding]; other site 1220533009778 Q-loop/lid; other site 1220533009779 ABC transporter signature motif; other site 1220533009780 Walker B; other site 1220533009781 D-loop; other site 1220533009782 H-loop/switch region; other site 1220533009783 Adenosylcobinamide amidohydrolase [Coenzyme metabolism]; Region: cbiZ; COG1865 1220533009784 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1220533009785 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533009786 ABC-ATPase subunit interface; other site 1220533009787 dimer interface [polypeptide binding]; other site 1220533009788 putative PBP binding regions; other site 1220533009789 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1220533009790 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1220533009791 putative binding site residues; other site 1220533009792 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1220533009793 classical (c) SDRs; Region: SDR_c; cd05233 1220533009794 NAD(P) binding site [chemical binding]; other site 1220533009795 active site 1220533009796 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1220533009797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533009798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533009799 dimer interface [polypeptide binding]; other site 1220533009800 phosphorylation site [posttranslational modification] 1220533009801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533009802 ATP binding site [chemical binding]; other site 1220533009803 Mg2+ binding site [ion binding]; other site 1220533009804 G-X-G motif; other site 1220533009805 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533009806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533009807 active site 1220533009808 phosphorylation site [posttranslational modification] 1220533009809 intermolecular recognition site; other site 1220533009810 dimerization interface [polypeptide binding]; other site 1220533009811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533009812 DNA binding site [nucleotide binding] 1220533009813 hypothetical protein; Provisional; Region: PRK14082 1220533009814 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1220533009815 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533009816 DNA binding residues [nucleotide binding] 1220533009817 YvrJ protein family; Region: YvrJ; pfam12841 1220533009818 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1220533009819 Cupin; Region: Cupin_1; smart00835 1220533009820 Cupin; Region: Cupin_1; smart00835 1220533009821 Regulatory protein YrvL; Region: YrvL; pfam14184 1220533009822 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1220533009823 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1220533009824 FtsX-like permease family; Region: FtsX; pfam02687 1220533009825 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1220533009826 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1220533009827 Walker A/P-loop; other site 1220533009828 ATP binding site [chemical binding]; other site 1220533009829 Q-loop/lid; other site 1220533009830 ABC transporter signature motif; other site 1220533009831 Walker B; other site 1220533009832 D-loop; other site 1220533009833 H-loop/switch region; other site 1220533009834 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1220533009835 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1220533009836 DNA damage checkpoint protein; Region: LCD1; pfam09798 1220533009837 HlyD family secretion protein; Region: HlyD_3; pfam13437 1220533009838 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1220533009839 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1220533009840 Walker A/P-loop; other site 1220533009841 ATP binding site [chemical binding]; other site 1220533009842 Q-loop/lid; other site 1220533009843 ABC transporter signature motif; other site 1220533009844 Walker B; other site 1220533009845 D-loop; other site 1220533009846 H-loop/switch region; other site 1220533009847 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1220533009848 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533009849 ABC-ATPase subunit interface; other site 1220533009850 dimer interface [polypeptide binding]; other site 1220533009851 putative PBP binding regions; other site 1220533009852 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1220533009853 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1220533009854 ABC-ATPase subunit interface; other site 1220533009855 dimer interface [polypeptide binding]; other site 1220533009856 putative PBP binding regions; other site 1220533009857 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1220533009858 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1220533009859 putative ligand binding residues [chemical binding]; other site 1220533009860 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1220533009861 Spore germination protein; Region: Spore_permease; cl17796 1220533009862 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 1220533009863 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1220533009864 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1220533009865 Sulfatase; Region: Sulfatase; pfam00884 1220533009866 DNA binding domain, excisionase family; Region: excise; TIGR01764 1220533009867 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1220533009868 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1220533009869 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1220533009870 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1220533009871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533009872 dimer interface [polypeptide binding]; other site 1220533009873 conserved gate region; other site 1220533009874 putative PBP binding loops; other site 1220533009875 ABC-ATPase subunit interface; other site 1220533009876 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1220533009877 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1220533009878 active site 1220533009879 catalytic tetrad [active] 1220533009880 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1220533009881 sulfite reductase subunit beta; Provisional; Region: PRK13504 1220533009882 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1220533009883 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1220533009884 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1220533009885 Flavodoxin; Region: Flavodoxin_1; pfam00258 1220533009886 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1220533009887 FAD binding pocket [chemical binding]; other site 1220533009888 FAD binding motif [chemical binding]; other site 1220533009889 catalytic residues [active] 1220533009890 NAD binding pocket [chemical binding]; other site 1220533009891 phosphate binding motif [ion binding]; other site 1220533009892 beta-alpha-beta structure motif; other site 1220533009893 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1220533009894 Part of AAA domain; Region: AAA_19; pfam13245 1220533009895 Family description; Region: UvrD_C_2; pfam13538 1220533009896 Predicted membrane protein [Function unknown]; Region: COG2860 1220533009897 UPF0126 domain; Region: UPF0126; pfam03458 1220533009898 UPF0126 domain; Region: UPF0126; pfam03458 1220533009899 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1220533009900 Thioredoxin; Region: Thioredoxin_4; pfam13462 1220533009901 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1220533009902 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1220533009903 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1220533009904 metal-binding site [ion binding] 1220533009905 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1220533009906 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1220533009907 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1220533009908 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1220533009909 metal-binding site [ion binding] 1220533009910 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1220533009911 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1220533009912 metal-binding site [ion binding] 1220533009913 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1220533009914 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1220533009915 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1220533009916 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1220533009917 metal-binding site [ion binding] 1220533009918 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1220533009919 putative homodimer interface [polypeptide binding]; other site 1220533009920 putative homotetramer interface [polypeptide binding]; other site 1220533009921 allosteric switch controlling residues; other site 1220533009922 putative metal binding site [ion binding]; other site 1220533009923 putative homodimer-homodimer interface [polypeptide binding]; other site 1220533009924 putative oxidoreductase; Provisional; Region: PRK11579 1220533009925 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1220533009926 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1220533009927 azoreductase; Reviewed; Region: PRK00170 1220533009928 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1220533009929 Predicted membrane protein [Function unknown]; Region: COG1289 1220533009930 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1220533009931 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1220533009932 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1220533009933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533009934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533009935 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1220533009936 classical (c) SDRs; Region: SDR_c; cd05233 1220533009937 NAD(P) binding site [chemical binding]; other site 1220533009938 active site 1220533009939 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1220533009940 SmpB-tmRNA interface; other site 1220533009941 ribonuclease R; Region: RNase_R; TIGR02063 1220533009942 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1220533009943 Cold shock protein domain; Region: CSP; smart00357 1220533009944 RNB domain; Region: RNB; pfam00773 1220533009945 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1220533009946 RNA binding site [nucleotide binding]; other site 1220533009947 Esterase/lipase [General function prediction only]; Region: COG1647 1220533009948 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1220533009949 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533009950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533009951 salt bridge; other site 1220533009952 non-specific DNA binding site [nucleotide binding]; other site 1220533009953 sequence-specific DNA binding site [nucleotide binding]; other site 1220533009954 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533009955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533009956 non-specific DNA binding site [nucleotide binding]; other site 1220533009957 salt bridge; other site 1220533009958 sequence-specific DNA binding site [nucleotide binding]; other site 1220533009959 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533009960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533009961 non-specific DNA binding site [nucleotide binding]; other site 1220533009962 salt bridge; other site 1220533009963 sequence-specific DNA binding site [nucleotide binding]; other site 1220533009964 Predicted transcriptional regulators [Transcription]; Region: COG1733 1220533009965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533009966 dimerization interface [polypeptide binding]; other site 1220533009967 putative DNA binding site [nucleotide binding]; other site 1220533009968 putative Zn2+ binding site [ion binding]; other site 1220533009969 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1220533009970 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533009971 dimerization interface [polypeptide binding]; other site 1220533009972 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1220533009973 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1220533009974 dimer interface [polypeptide binding]; other site 1220533009975 putative CheW interface [polypeptide binding]; other site 1220533009976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533009977 dimer interface [polypeptide binding]; other site 1220533009978 conserved gate region; other site 1220533009979 putative PBP binding loops; other site 1220533009980 ABC-ATPase subunit interface; other site 1220533009981 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1220533009982 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1220533009983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533009984 dimer interface [polypeptide binding]; other site 1220533009985 conserved gate region; other site 1220533009986 putative PBP binding loops; other site 1220533009987 ABC-ATPase subunit interface; other site 1220533009988 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1220533009989 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1220533009990 Walker A/P-loop; other site 1220533009991 ATP binding site [chemical binding]; other site 1220533009992 Q-loop/lid; other site 1220533009993 ABC transporter signature motif; other site 1220533009994 Walker B; other site 1220533009995 D-loop; other site 1220533009996 H-loop/switch region; other site 1220533009997 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1220533009998 Predicted transcriptional regulators [Transcription]; Region: COG1510 1220533009999 MarR family; Region: MarR_2; pfam12802 1220533010000 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1220533010001 antimicrobial peptide system protein, SdpB family; Region: export_SdpB; TIGR04033 1220533010002 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1220533010003 Predicted integral membrane protein [Function unknown]; Region: COG5658 1220533010004 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1220533010005 SdpI/YhfL protein family; Region: SdpI; pfam13630 1220533010006 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533010007 dimerization interface [polypeptide binding]; other site 1220533010008 putative DNA binding site [nucleotide binding]; other site 1220533010009 putative Zn2+ binding site [ion binding]; other site 1220533010010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533010011 dimer interface [polypeptide binding]; other site 1220533010012 conserved gate region; other site 1220533010013 putative PBP binding loops; other site 1220533010014 ABC-ATPase subunit interface; other site 1220533010015 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1220533010016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533010017 dimer interface [polypeptide binding]; other site 1220533010018 conserved gate region; other site 1220533010019 putative PBP binding loops; other site 1220533010020 ABC-ATPase subunit interface; other site 1220533010021 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1220533010022 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1220533010023 Walker A/P-loop; other site 1220533010024 ATP binding site [chemical binding]; other site 1220533010025 Q-loop/lid; other site 1220533010026 ABC transporter signature motif; other site 1220533010027 Walker B; other site 1220533010028 D-loop; other site 1220533010029 H-loop/switch region; other site 1220533010030 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1220533010031 Predicted transcriptional regulators [Transcription]; Region: COG1510 1220533010032 MarR family; Region: MarR_2; pfam12802 1220533010033 membrane protein, MarC family; Region: TIGR00427 1220533010034 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1220533010035 pentamer interface [polypeptide binding]; other site 1220533010036 dodecaamer interface [polypeptide binding]; other site 1220533010037 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1220533010038 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1220533010039 Double zinc ribbon; Region: DZR; pfam12773 1220533010040 Predicted membrane protein [Function unknown]; Region: COG4640 1220533010041 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1220533010042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533010043 Coenzyme A binding pocket [chemical binding]; other site 1220533010044 enolase; Provisional; Region: eno; PRK00077 1220533010045 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1220533010046 dimer interface [polypeptide binding]; other site 1220533010047 metal binding site [ion binding]; metal-binding site 1220533010048 substrate binding pocket [chemical binding]; other site 1220533010049 phosphoglyceromutase; Provisional; Region: PRK05434 1220533010050 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1220533010051 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1220533010052 triosephosphate isomerase; Provisional; Region: PRK14565 1220533010053 substrate binding site [chemical binding]; other site 1220533010054 dimer interface [polypeptide binding]; other site 1220533010055 catalytic triad [active] 1220533010056 Phosphoglycerate kinase; Region: PGK; pfam00162 1220533010057 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1220533010058 substrate binding site [chemical binding]; other site 1220533010059 hinge regions; other site 1220533010060 ADP binding site [chemical binding]; other site 1220533010061 catalytic site [active] 1220533010062 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1220533010063 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1220533010064 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1220533010065 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1220533010066 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1220533010067 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1220533010068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533010069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533010070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533010071 DNA-binding site [nucleotide binding]; DNA binding site 1220533010072 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1220533010073 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1220533010074 putative dimerization interface [polypeptide binding]; other site 1220533010075 putative ligand binding site [chemical binding]; other site 1220533010076 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1220533010077 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1220533010078 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1220533010079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533010080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533010081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533010082 dimerization interface [polypeptide binding]; other site 1220533010083 EamA-like transporter family; Region: EamA; pfam00892 1220533010084 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1220533010085 EamA-like transporter family; Region: EamA; pfam00892 1220533010086 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1220533010087 T-box; B657_miscRNA56 1220533010088 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1220533010089 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1220533010090 active site 1220533010091 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1220533010092 iron-sulfur cluster-binding protein; Region: TIGR00273 1220533010093 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1220533010094 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1220533010095 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1220533010096 Cysteine-rich domain; Region: CCG; pfam02754 1220533010097 Cysteine-rich domain; Region: CCG; pfam02754 1220533010098 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533010099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533010100 active site 1220533010101 phosphorylation site [posttranslational modification] 1220533010102 intermolecular recognition site; other site 1220533010103 dimerization interface [polypeptide binding]; other site 1220533010104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533010105 DNA binding residues [nucleotide binding] 1220533010106 dimerization interface [polypeptide binding]; other site 1220533010107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1220533010108 Histidine kinase; Region: HisKA_3; pfam07730 1220533010109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533010110 ATP binding site [chemical binding]; other site 1220533010111 Mg2+ binding site [ion binding]; other site 1220533010112 G-X-G motif; other site 1220533010113 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1220533010114 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1220533010115 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1220533010116 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1220533010117 Walker A/P-loop; other site 1220533010118 ATP binding site [chemical binding]; other site 1220533010119 Q-loop/lid; other site 1220533010120 ABC transporter signature motif; other site 1220533010121 Walker B; other site 1220533010122 D-loop; other site 1220533010123 H-loop/switch region; other site 1220533010124 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1220533010125 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1220533010126 catalytic site [active] 1220533010127 PAS domain S-box; Region: sensory_box; TIGR00229 1220533010128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533010129 putative active site [active] 1220533010130 heme pocket [chemical binding]; other site 1220533010131 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1220533010132 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1220533010133 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1220533010134 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1220533010135 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1220533010136 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1220533010137 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1220533010138 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1220533010139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533010140 dimer interface [polypeptide binding]; other site 1220533010141 conserved gate region; other site 1220533010142 putative PBP binding loops; other site 1220533010143 ABC-ATPase subunit interface; other site 1220533010144 TM2 domain; Region: TM2; pfam05154 1220533010145 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1220533010146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533010147 dimer interface [polypeptide binding]; other site 1220533010148 conserved gate region; other site 1220533010149 ABC-ATPase subunit interface; other site 1220533010150 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1220533010151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1220533010152 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1220533010153 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533010154 DNA binding site [nucleotide binding] 1220533010155 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1220533010156 putative dimerization interface [polypeptide binding]; other site 1220533010157 putative ligand binding site [chemical binding]; other site 1220533010158 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1220533010159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533010160 DNA-binding site [nucleotide binding]; DNA binding site 1220533010161 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1220533010162 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1220533010163 L-lactate permease; Region: Lactate_perm; pfam02652 1220533010164 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1220533010165 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1220533010166 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1220533010167 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1220533010168 YvfG protein; Region: YvfG; pfam09628 1220533010169 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1220533010170 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1220533010171 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1220533010172 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1220533010173 inhibitor-cofactor binding pocket; inhibition site 1220533010174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533010175 catalytic residue [active] 1220533010176 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1220533010177 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1220533010178 putative trimer interface [polypeptide binding]; other site 1220533010179 putative CoA binding site [chemical binding]; other site 1220533010180 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1220533010181 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1220533010182 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533010183 active site 1220533010184 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1220533010185 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1220533010186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533010187 active site 1220533010188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1220533010189 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1220533010190 putative ADP-binding pocket [chemical binding]; other site 1220533010191 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1220533010192 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533010193 active site 1220533010194 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1220533010195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1220533010196 putative ADP-binding pocket [chemical binding]; other site 1220533010197 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1220533010198 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1220533010199 NAD(P) binding site [chemical binding]; other site 1220533010200 homodimer interface [polypeptide binding]; other site 1220533010201 substrate binding site [chemical binding]; other site 1220533010202 active site 1220533010203 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1220533010204 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1220533010205 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1220533010206 Chain length determinant protein; Region: Wzz; cl15801 1220533010207 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1220533010208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1220533010209 non-specific DNA binding site [nucleotide binding]; other site 1220533010210 salt bridge; other site 1220533010211 sequence-specific DNA binding site [nucleotide binding]; other site 1220533010212 Anti-repressor SinI; Region: SinI; pfam08671 1220533010213 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1220533010214 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1220533010215 substrate binding pocket [chemical binding]; other site 1220533010216 catalytic triad [active] 1220533010217 Phenolic acid decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3479 1220533010218 hypothetical protein; Provisional; Region: PRK00872 1220533010219 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 1220533010220 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1220533010221 aspartate racemase; Region: asp_race; TIGR00035 1220533010222 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1220533010223 Beta-lactamase; Region: Beta-lactamase; pfam00144 1220533010224 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1220533010225 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1220533010226 active site 1220533010227 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1220533010228 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1220533010229 substrate binding [chemical binding]; other site 1220533010230 active site 1220533010231 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1220533010232 amino acid transporter; Region: 2A0306; TIGR00909 1220533010233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533010234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533010235 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1220533010236 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1220533010237 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1220533010238 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1220533010239 FAD binding domain; Region: FAD_binding_4; pfam01565 1220533010240 Berberine and berberine like; Region: BBE; pfam08031 1220533010241 Patatin [General function prediction only]; Region: COG3621 1220533010242 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1220533010243 active site 1220533010244 nucleophile elbow; other site 1220533010245 Clp protease; Region: CLP_protease; pfam00574 1220533010246 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1220533010247 oligomer interface [polypeptide binding]; other site 1220533010248 active site residues [active] 1220533010249 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1220533010250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533010251 motif II; other site 1220533010252 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1220533010253 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1220533010254 Ca binding site [ion binding]; other site 1220533010255 active site 1220533010256 catalytic site [active] 1220533010257 maltose phosphorylase; Provisional; Region: PRK13807 1220533010258 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1220533010259 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1220533010260 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1220533010261 Predicted integral membrane protein [Function unknown]; Region: COG5521 1220533010262 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1220533010263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533010264 dimer interface [polypeptide binding]; other site 1220533010265 conserved gate region; other site 1220533010266 ABC-ATPase subunit interface; other site 1220533010267 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1220533010268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533010269 dimer interface [polypeptide binding]; other site 1220533010270 conserved gate region; other site 1220533010271 putative PBP binding loops; other site 1220533010272 ABC-ATPase subunit interface; other site 1220533010273 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1220533010274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1220533010275 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1220533010276 homodimer interface [polypeptide binding]; other site 1220533010277 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1220533010278 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1220533010279 active site 1220533010280 homodimer interface [polypeptide binding]; other site 1220533010281 catalytic site [active] 1220533010282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1220533010283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533010284 DNA binding site [nucleotide binding] 1220533010285 domain linker motif; other site 1220533010286 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1220533010287 ligand binding site [chemical binding]; other site 1220533010288 dimerization interface [polypeptide binding]; other site 1220533010289 TIGR00730 family protein; Region: TIGR00730 1220533010290 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1220533010291 metal binding site [ion binding]; metal-binding site 1220533010292 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1220533010293 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1220533010294 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1220533010295 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1220533010296 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1220533010297 active site clefts [active] 1220533010298 zinc binding site [ion binding]; other site 1220533010299 dimer interface [polypeptide binding]; other site 1220533010300 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1220533010301 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1220533010302 dimerization interface [polypeptide binding]; other site 1220533010303 ligand binding site [chemical binding]; other site 1220533010304 NADP binding site [chemical binding]; other site 1220533010305 catalytic site [active] 1220533010306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1220533010307 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1220533010308 Walker A/P-loop; other site 1220533010309 ATP binding site [chemical binding]; other site 1220533010310 Q-loop/lid; other site 1220533010311 ABC transporter signature motif; other site 1220533010312 Walker B; other site 1220533010313 D-loop; other site 1220533010314 H-loop/switch region; other site 1220533010315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533010316 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1220533010317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533010318 ATP binding site [chemical binding]; other site 1220533010319 Mg2+ binding site [ion binding]; other site 1220533010320 G-X-G motif; other site 1220533010321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533010322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533010323 active site 1220533010324 phosphorylation site [posttranslational modification] 1220533010325 intermolecular recognition site; other site 1220533010326 dimerization interface [polypeptide binding]; other site 1220533010327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533010328 DNA binding site [nucleotide binding] 1220533010329 Lysis protein; Region: Lysis_col; pfam02402 1220533010330 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1220533010331 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1220533010332 dimerization domain swap beta strand [polypeptide binding]; other site 1220533010333 regulatory protein interface [polypeptide binding]; other site 1220533010334 active site 1220533010335 regulatory phosphorylation site [posttranslational modification]; other site 1220533010336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1220533010337 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1220533010338 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1220533010339 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1220533010340 phosphate binding site [ion binding]; other site 1220533010341 putative substrate binding pocket [chemical binding]; other site 1220533010342 dimer interface [polypeptide binding]; other site 1220533010343 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1220533010344 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1220533010345 putative active site [active] 1220533010346 nucleotide binding site [chemical binding]; other site 1220533010347 nudix motif; other site 1220533010348 putative metal binding site [ion binding]; other site 1220533010349 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1220533010350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1220533010351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533010352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1220533010353 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1220533010354 NlpC/P60 family; Region: NLPC_P60; pfam00877 1220533010355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533010356 binding surface 1220533010357 TPR motif; other site 1220533010358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533010359 TPR motif; other site 1220533010360 binding surface 1220533010361 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1220533010362 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533010363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1220533010364 Walker A/P-loop; other site 1220533010365 ATP binding site [chemical binding]; other site 1220533010366 Q-loop/lid; other site 1220533010367 ABC transporter signature motif; other site 1220533010368 Walker B; other site 1220533010369 D-loop; other site 1220533010370 H-loop/switch region; other site 1220533010371 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1220533010372 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1220533010373 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1220533010374 metal binding site [ion binding]; metal-binding site 1220533010375 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1220533010376 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1220533010377 substrate binding site [chemical binding]; other site 1220533010378 glutamase interaction surface [polypeptide binding]; other site 1220533010379 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1220533010380 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1220533010381 catalytic residues [active] 1220533010382 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1220533010383 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1220533010384 putative active site [active] 1220533010385 oxyanion strand; other site 1220533010386 catalytic triad [active] 1220533010387 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1220533010388 putative active site pocket [active] 1220533010389 4-fold oligomerization interface [polypeptide binding]; other site 1220533010390 metal binding residues [ion binding]; metal-binding site 1220533010391 3-fold/trimer interface [polypeptide binding]; other site 1220533010392 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1220533010393 histidinol dehydrogenase; Region: hisD; TIGR00069 1220533010394 NAD binding site [chemical binding]; other site 1220533010395 dimerization interface [polypeptide binding]; other site 1220533010396 product binding site; other site 1220533010397 substrate binding site [chemical binding]; other site 1220533010398 zinc binding site [ion binding]; other site 1220533010399 catalytic residues [active] 1220533010400 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1220533010401 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1220533010402 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1220533010403 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1220533010404 dimer interface [polypeptide binding]; other site 1220533010405 motif 1; other site 1220533010406 active site 1220533010407 motif 2; other site 1220533010408 motif 3; other site 1220533010409 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1220533010410 putative active site [active] 1220533010411 Pectate lyase; Region: Pectate_lyase; pfam03211 1220533010412 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1220533010413 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1220533010414 CoA binding site [chemical binding]; other site 1220533010415 active site 1220533010416 pyrophosphatase PpaX; Provisional; Region: PRK13288 1220533010417 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1220533010418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533010419 motif II; other site 1220533010420 Nucleoside recognition; Region: Gate; pfam07670 1220533010421 Nucleoside recognition; Region: Gate; pfam07670 1220533010422 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1220533010423 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1220533010424 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1220533010425 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1220533010426 Hpr binding site; other site 1220533010427 active site 1220533010428 homohexamer subunit interaction site [polypeptide binding]; other site 1220533010429 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1220533010430 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1220533010431 active site 1220533010432 dimer interface [polypeptide binding]; other site 1220533010433 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1220533010434 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1220533010435 active site 1220533010436 trimer interface [polypeptide binding]; other site 1220533010437 allosteric site; other site 1220533010438 active site lid [active] 1220533010439 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1220533010440 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1220533010441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533010442 DNA-binding site [nucleotide binding]; DNA binding site 1220533010443 UTRA domain; Region: UTRA; pfam07702 1220533010444 Lamin Tail Domain; Region: LTD; pfam00932 1220533010445 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1220533010446 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1220533010447 putative active site [active] 1220533010448 putative metal binding site [ion binding]; other site 1220533010449 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533010450 MarR family; Region: MarR; pfam01047 1220533010451 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1220533010452 Cytochrome P450; Region: p450; cl12078 1220533010453 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533010454 MarR family; Region: MarR; pfam01047 1220533010455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533010456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533010457 putative substrate translocation pore; other site 1220533010458 Predicted membrane protein [Function unknown]; Region: COG1950 1220533010459 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1220533010460 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1220533010461 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1220533010462 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1220533010463 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1220533010464 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1220533010465 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1220533010466 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1220533010467 excinuclease ABC subunit B; Provisional; Region: PRK05298 1220533010468 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533010469 ATP binding site [chemical binding]; other site 1220533010470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533010471 nucleotide binding region [chemical binding]; other site 1220533010472 ATP-binding site [chemical binding]; other site 1220533010473 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1220533010474 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1220533010475 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1220533010476 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 1220533010477 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1220533010478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533010479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533010480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533010481 putative substrate translocation pore; other site 1220533010482 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1220533010483 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1220533010484 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1220533010485 C-terminal peptidase (prc); Region: prc; TIGR00225 1220533010486 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1220533010487 protein binding site [polypeptide binding]; other site 1220533010488 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1220533010489 Catalytic dyad [active] 1220533010490 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1220533010491 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1220533010492 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1220533010493 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1220533010494 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 1220533010495 Walker A/P-loop; other site 1220533010496 ATP binding site [chemical binding]; other site 1220533010497 Q-loop/lid; other site 1220533010498 ABC transporter signature motif; other site 1220533010499 Walker B; other site 1220533010500 D-loop; other site 1220533010501 H-loop/switch region; other site 1220533010502 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1220533010503 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1220533010504 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1220533010505 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533010506 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533010507 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1220533010508 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1220533010509 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1220533010510 RF-1 domain; Region: RF-1; pfam00472 1220533010511 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1220533010512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1220533010513 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1220533010514 nucleotide binding region [chemical binding]; other site 1220533010515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1220533010516 ATP-binding site [chemical binding]; other site 1220533010517 SEC-C motif; Region: SEC-C; pfam02810 1220533010518 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1220533010519 30S subunit binding site; other site 1220533010520 Flagellar protein FliT; Region: FliT; pfam05400 1220533010521 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 1220533010522 flagellar capping protein; Validated; Region: fliD; PRK07737 1220533010523 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1220533010524 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1220533010525 flagellar protein FlaG; Provisional; Region: PRK07738 1220533010526 flagellin; Provisional; Region: PRK12804 1220533010527 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1220533010528 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1220533010529 carbon storage regulator; Provisional; Region: PRK01712 1220533010530 flagellar assembly protein FliW; Provisional; Region: PRK13285 1220533010531 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1220533010532 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1220533010533 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1220533010534 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1220533010535 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1220533010536 FlgN protein; Region: FlgN; pfam05130 1220533010537 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 1220533010538 flagellar operon protein TIGR03826; Region: YvyF 1220533010539 comF family protein; Region: comF; TIGR00201 1220533010540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533010541 active site 1220533010542 Late competence development protein ComFB; Region: ComFB; pfam10719 1220533010543 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1220533010544 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533010545 ATP binding site [chemical binding]; other site 1220533010546 putative Mg++ binding site [ion binding]; other site 1220533010547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533010548 nucleotide binding region [chemical binding]; other site 1220533010549 ATP-binding site [chemical binding]; other site 1220533010550 EDD domain protein, DegV family; Region: DegV; TIGR00762 1220533010551 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1220533010552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533010553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533010554 active site 1220533010555 phosphorylation site [posttranslational modification] 1220533010556 intermolecular recognition site; other site 1220533010557 dimerization interface [polypeptide binding]; other site 1220533010558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533010559 DNA binding residues [nucleotide binding] 1220533010560 dimerization interface [polypeptide binding]; other site 1220533010561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1220533010562 Histidine kinase; Region: HisKA_3; pfam07730 1220533010563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533010564 ATP binding site [chemical binding]; other site 1220533010565 Mg2+ binding site [ion binding]; other site 1220533010566 G-X-G motif; other site 1220533010567 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1220533010568 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1220533010569 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1220533010570 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1220533010571 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1220533010572 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1220533010573 Mg++ binding site [ion binding]; other site 1220533010574 putative catalytic motif [active] 1220533010575 substrate binding site [chemical binding]; other site 1220533010576 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1220533010577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1220533010578 putative homodimer interface [polypeptide binding]; other site 1220533010579 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1220533010580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533010581 active site 1220533010582 Chain length determinant protein; Region: Wzz; pfam02706 1220533010583 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1220533010584 O-Antigen ligase; Region: Wzy_C; pfam04932 1220533010585 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1220533010586 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1220533010587 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1220533010588 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1220533010589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1220533010590 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1220533010591 colanic acid exporter; Provisional; Region: PRK10459 1220533010592 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1220533010593 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1220533010594 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1220533010595 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1220533010596 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1220533010597 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1220533010598 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1220533010599 active site 1220533010600 metal binding site [ion binding]; metal-binding site 1220533010601 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1220533010602 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1220533010603 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1220533010604 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1220533010605 Stage II sporulation protein; Region: SpoIID; pfam08486 1220533010606 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1220533010607 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1220533010608 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1220533010609 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1220533010610 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1220533010611 active site 1220533010612 homodimer interface [polypeptide binding]; other site 1220533010613 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1220533010614 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1220533010615 active site 1220533010616 tetramer interface; other site 1220533010617 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533010618 active site 1220533010619 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1220533010620 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1220533010621 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1220533010622 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533010623 active site 1220533010624 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1220533010625 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1220533010626 Walker A/P-loop; other site 1220533010627 ATP binding site [chemical binding]; other site 1220533010628 Q-loop/lid; other site 1220533010629 ABC transporter signature motif; other site 1220533010630 Walker B; other site 1220533010631 D-loop; other site 1220533010632 H-loop/switch region; other site 1220533010633 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1220533010634 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1220533010635 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1220533010636 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1220533010637 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1220533010638 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1220533010639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1220533010640 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1220533010641 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1220533010642 active site 1220533010643 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1220533010644 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1220533010645 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1220533010646 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1220533010647 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1220533010648 Bacterial SH3 domain; Region: SH3_3; pfam08239 1220533010649 Lysozyme subfamily 2; Region: LYZ2; smart00047 1220533010650 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1220533010651 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1220533010652 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1220533010653 Spore germination protein; Region: Spore_permease; pfam03845 1220533010654 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1220533010655 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1220533010656 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1220533010657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533010658 putative substrate translocation pore; other site 1220533010659 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1220533010660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533010661 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1220533010662 active site 1220533010663 motif I; other site 1220533010664 motif II; other site 1220533010665 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1220533010666 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1220533010667 NlpC/P60 family; Region: NLPC_P60; pfam00877 1220533010668 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1220533010669 NlpC/P60 family; Region: NLPC_P60; pfam00877 1220533010670 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1220533010671 NlpC/P60 family; Region: NLPC_P60; pfam00877 1220533010672 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1220533010673 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1220533010674 putative active site [active] 1220533010675 putative metal binding site [ion binding]; other site 1220533010676 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1220533010677 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1220533010678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1220533010679 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1220533010680 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533010681 DNA binding site [nucleotide binding] 1220533010682 domain linker motif; other site 1220533010683 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1220533010684 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1220533010685 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1220533010686 substrate binding site [chemical binding]; other site 1220533010687 dimer interface [polypeptide binding]; other site 1220533010688 ATP binding site [chemical binding]; other site 1220533010689 D-ribose pyranase; Provisional; Region: PRK11797 1220533010690 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1220533010691 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1220533010692 Walker A/P-loop; other site 1220533010693 ATP binding site [chemical binding]; other site 1220533010694 Q-loop/lid; other site 1220533010695 ABC transporter signature motif; other site 1220533010696 Walker B; other site 1220533010697 D-loop; other site 1220533010698 H-loop/switch region; other site 1220533010699 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1220533010700 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1220533010701 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1220533010702 TM-ABC transporter signature motif; other site 1220533010703 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1220533010704 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1220533010705 ligand binding site [chemical binding]; other site 1220533010706 dimerization interface [polypeptide binding]; other site 1220533010707 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1220533010708 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1220533010709 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1220533010710 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1220533010711 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1220533010712 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1220533010713 acetolactate synthase; Reviewed; Region: PRK08617 1220533010714 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1220533010715 PYR/PP interface [polypeptide binding]; other site 1220533010716 dimer interface [polypeptide binding]; other site 1220533010717 TPP binding site [chemical binding]; other site 1220533010718 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1220533010719 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1220533010720 TPP-binding site [chemical binding]; other site 1220533010721 dimer interface [polypeptide binding]; other site 1220533010722 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1220533010723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533010724 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1220533010725 putative dimerization interface [polypeptide binding]; other site 1220533010726 putative substrate binding pocket [chemical binding]; other site 1220533010727 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1220533010728 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1220533010729 transmembrane helices; other site 1220533010730 CotH protein; Region: CotH; pfam08757 1220533010731 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1220533010732 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1220533010733 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1220533010734 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1220533010735 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1220533010736 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533010737 putative DNA binding site [nucleotide binding]; other site 1220533010738 putative Zn2+ binding site [ion binding]; other site 1220533010739 AsnC family; Region: AsnC_trans_reg; pfam01037 1220533010740 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1220533010741 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1220533010742 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1220533010743 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1220533010744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533010745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533010746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533010747 dimerization interface [polypeptide binding]; other site 1220533010748 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1220533010749 Active_site [active] 1220533010750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1220533010751 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1220533010752 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1220533010753 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 1220533010754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1220533010755 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1220533010756 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1220533010757 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1220533010758 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1220533010759 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1220533010760 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1220533010761 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1220533010762 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1220533010763 Chain length determinant protein; Region: Wzz; cl15801 1220533010764 SWIM zinc finger; Region: SWIM; pfam04434 1220533010765 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1220533010766 SNF2 Helicase protein; Region: DUF3670; pfam12419 1220533010767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1220533010768 ATP binding site [chemical binding]; other site 1220533010769 putative Mg++ binding site [ion binding]; other site 1220533010770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533010771 nucleotide binding region [chemical binding]; other site 1220533010772 ATP-binding site [chemical binding]; other site 1220533010773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533010774 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1220533010775 active site 1220533010776 motif I; other site 1220533010777 motif II; other site 1220533010778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533010779 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1220533010780 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1220533010781 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1220533010782 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1220533010783 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1220533010784 dimer interface [polypeptide binding]; other site 1220533010785 ssDNA binding site [nucleotide binding]; other site 1220533010786 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1220533010787 YwpF-like protein; Region: YwpF; pfam14183 1220533010788 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1220533010789 active site 1220533010790 catalytic site [active] 1220533010791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533010792 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533010793 intermolecular recognition site; other site 1220533010794 active site 1220533010795 dimerization interface [polypeptide binding]; other site 1220533010796 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1220533010797 Histidine kinase; Region: His_kinase; pfam06580 1220533010798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533010799 ATP binding site [chemical binding]; other site 1220533010800 Mg2+ binding site [ion binding]; other site 1220533010801 G-X-G motif; other site 1220533010802 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1220533010803 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1220533010804 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1220533010805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533010806 binding surface 1220533010807 TPR motif; other site 1220533010808 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1220533010809 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1220533010810 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1220533010811 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1220533010812 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1220533010813 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1220533010814 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1220533010815 MreB and similar proteins; Region: MreB_like; cd10225 1220533010816 nucleotide binding site [chemical binding]; other site 1220533010817 Mg binding site [ion binding]; other site 1220533010818 putative protofilament interaction site [polypeptide binding]; other site 1220533010819 RodZ interaction site [polypeptide binding]; other site 1220533010820 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1220533010821 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533010822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533010823 putative Zn2+ binding site [ion binding]; other site 1220533010824 putative DNA binding site [nucleotide binding]; other site 1220533010825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533010826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533010827 putative substrate translocation pore; other site 1220533010828 Right handed beta helix region; Region: Beta_helix; pfam13229 1220533010829 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1220533010830 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1220533010831 Na binding site [ion binding]; other site 1220533010832 putative substrate binding site [chemical binding]; other site 1220533010833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533010834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533010835 putative substrate translocation pore; other site 1220533010836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533010837 Isochorismatase family; Region: Isochorismatase; pfam00857 1220533010838 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1220533010839 catalytic triad [active] 1220533010840 conserved cis-peptide bond; other site 1220533010841 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1220533010842 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1220533010843 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1220533010844 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1220533010845 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1220533010846 active site 1220533010847 VanZ like family; Region: VanZ; pfam04892 1220533010848 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1220533010849 Peptidase family M23; Region: Peptidase_M23; pfam01551 1220533010850 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1220533010851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533010852 Coenzyme A binding pocket [chemical binding]; other site 1220533010853 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1220533010854 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1220533010855 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1220533010856 putative active site [active] 1220533010857 catalytic site [active] 1220533010858 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1220533010859 putative active site [active] 1220533010860 catalytic site [active] 1220533010861 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1220533010862 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1220533010863 DNA binding residues [nucleotide binding] 1220533010864 dimer interface [polypeptide binding]; other site 1220533010865 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1220533010866 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1220533010867 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1220533010868 NAD binding site [chemical binding]; other site 1220533010869 substrate binding site [chemical binding]; other site 1220533010870 putative active site [active] 1220533010871 Predicted transcriptional regulator [Transcription]; Region: COG1959 1220533010872 Transcriptional regulator; Region: Rrf2; pfam02082 1220533010873 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1220533010874 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1220533010875 subunit interactions [polypeptide binding]; other site 1220533010876 active site 1220533010877 flap region; other site 1220533010878 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1220533010879 gamma-beta subunit interface [polypeptide binding]; other site 1220533010880 alpha-beta subunit interface [polypeptide binding]; other site 1220533010881 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1220533010882 alpha-gamma subunit interface [polypeptide binding]; other site 1220533010883 beta-gamma subunit interface [polypeptide binding]; other site 1220533010884 CsbD-like; Region: CsbD; pfam05532 1220533010885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533010886 binding surface 1220533010887 TPR motif; other site 1220533010888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533010889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533010890 binding surface 1220533010891 TPR motif; other site 1220533010892 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1220533010893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533010894 FeS/SAM binding site; other site 1220533010895 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1220533010896 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1220533010897 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1220533010898 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1220533010899 metal ion-dependent adhesion site (MIDAS); other site 1220533010900 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1220533010901 metal ion-dependent adhesion site (MIDAS); other site 1220533010902 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1220533010903 Stage II sporulation protein; Region: SpoIID; pfam08486 1220533010904 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1220533010905 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1220533010906 hinge; other site 1220533010907 active site 1220533010908 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1220533010909 Predicted membrane protein [Function unknown]; Region: COG4836 1220533010910 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1220533010911 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1220533010912 gamma subunit interface [polypeptide binding]; other site 1220533010913 epsilon subunit interface [polypeptide binding]; other site 1220533010914 LBP interface [polypeptide binding]; other site 1220533010915 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1220533010916 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1220533010917 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1220533010918 alpha subunit interaction interface [polypeptide binding]; other site 1220533010919 Walker A motif; other site 1220533010920 ATP binding site [chemical binding]; other site 1220533010921 Walker B motif; other site 1220533010922 inhibitor binding site; inhibition site 1220533010923 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1220533010924 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1220533010925 core domain interface [polypeptide binding]; other site 1220533010926 delta subunit interface [polypeptide binding]; other site 1220533010927 epsilon subunit interface [polypeptide binding]; other site 1220533010928 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1220533010929 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1220533010930 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1220533010931 beta subunit interaction interface [polypeptide binding]; other site 1220533010932 Walker A motif; other site 1220533010933 ATP binding site [chemical binding]; other site 1220533010934 Walker B motif; other site 1220533010935 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1220533010936 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1220533010937 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1220533010938 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1220533010939 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1220533010940 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1220533010941 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1220533010942 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1220533010943 active site 1220533010944 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1220533010945 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1220533010946 dimer interface [polypeptide binding]; other site 1220533010947 active site 1220533010948 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1220533010949 folate binding site [chemical binding]; other site 1220533010950 hypothetical protein; Provisional; Region: PRK13690 1220533010951 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1220533010952 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1220533010953 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1220533010954 active site 1220533010955 Predicted membrane protein [Function unknown]; Region: COG1971 1220533010956 Domain of unknown function DUF; Region: DUF204; pfam02659 1220533010957 Domain of unknown function DUF; Region: DUF204; pfam02659 1220533010958 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1220533010959 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1220533010960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1220533010961 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1220533010962 HemK family putative methylases; Region: hemK_fam; TIGR00536 1220533010963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533010964 S-adenosylmethionine binding site [chemical binding]; other site 1220533010965 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1220533010966 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1220533010967 RF-1 domain; Region: RF-1; pfam00472 1220533010968 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1220533010969 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533010970 putative metal binding site [ion binding]; other site 1220533010971 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1220533010972 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1220533010973 DNA binding residues [nucleotide binding] 1220533010974 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1220533010975 malate dehydrogenase; Provisional; Region: PRK13529 1220533010976 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1220533010977 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1220533010978 NAD(P) binding site [chemical binding]; other site 1220533010979 thymidine kinase; Provisional; Region: PRK04296 1220533010980 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1220533010981 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1220533010982 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1220533010983 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1220533010984 RNA binding site [nucleotide binding]; other site 1220533010985 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1220533010986 multimer interface [polypeptide binding]; other site 1220533010987 Walker A motif; other site 1220533010988 ATP binding site [chemical binding]; other site 1220533010989 Walker B motif; other site 1220533010990 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1220533010991 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1220533010992 putative active site [active] 1220533010993 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1220533010994 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1220533010995 hinge; other site 1220533010996 active site 1220533010997 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1220533010998 active site 1220533010999 intersubunit interactions; other site 1220533011000 catalytic residue [active] 1220533011001 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1220533011002 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1220533011003 intersubunit interface [polypeptide binding]; other site 1220533011004 active site 1220533011005 zinc binding site [ion binding]; other site 1220533011006 Na+ binding site [ion binding]; other site 1220533011007 Response regulator receiver domain; Region: Response_reg; pfam00072 1220533011008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533011009 active site 1220533011010 phosphorylation site [posttranslational modification] 1220533011011 intermolecular recognition site; other site 1220533011012 dimerization interface [polypeptide binding]; other site 1220533011013 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1220533011014 CTP synthetase; Validated; Region: pyrG; PRK05380 1220533011015 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1220533011016 Catalytic site [active] 1220533011017 active site 1220533011018 UTP binding site [chemical binding]; other site 1220533011019 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1220533011020 active site 1220533011021 putative oxyanion hole; other site 1220533011022 catalytic triad [active] 1220533011023 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1220533011024 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1220533011025 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1220533011026 FAD binding site [chemical binding]; other site 1220533011027 homotetramer interface [polypeptide binding]; other site 1220533011028 substrate binding pocket [chemical binding]; other site 1220533011029 catalytic base [active] 1220533011030 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1220533011031 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1220533011032 Cysteine-rich domain; Region: CCG; pfam02754 1220533011033 Cysteine-rich domain; Region: CCG; pfam02754 1220533011034 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1220533011035 putative active site [active] 1220533011036 catalytic site [active] 1220533011037 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1220533011038 PLD-like domain; Region: PLDc_2; pfam13091 1220533011039 putative active site [active] 1220533011040 catalytic site [active] 1220533011041 UV damage endonuclease UvdE; Region: uvde; TIGR00629 1220533011042 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1220533011043 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1220533011044 folate binding site [chemical binding]; other site 1220533011045 NADP+ binding site [chemical binding]; other site 1220533011046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1220533011047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533011048 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1220533011049 Walker A/P-loop; other site 1220533011050 ATP binding site [chemical binding]; other site 1220533011051 Q-loop/lid; other site 1220533011052 ABC transporter signature motif; other site 1220533011053 Walker B; other site 1220533011054 D-loop; other site 1220533011055 H-loop/switch region; other site 1220533011056 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1220533011057 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1220533011058 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1220533011059 putative active site [active] 1220533011060 catalytic site [active] 1220533011061 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1220533011062 putative active site [active] 1220533011063 catalytic site [active] 1220533011064 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1220533011065 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1220533011066 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1220533011067 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1220533011068 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1220533011069 [4Fe-4S] binding site [ion binding]; other site 1220533011070 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1220533011071 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1220533011072 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1220533011073 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1220533011074 molybdopterin cofactor binding site; other site 1220533011075 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1220533011076 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1220533011077 ligand binding site [chemical binding]; other site 1220533011078 flexible hinge region; other site 1220533011079 YwiC-like protein; Region: YwiC; pfam14256 1220533011080 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1220533011081 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1220533011082 ligand binding site [chemical binding]; other site 1220533011083 flexible hinge region; other site 1220533011084 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1220533011085 putative switch regulator; other site 1220533011086 non-specific DNA interactions [nucleotide binding]; other site 1220533011087 DNA binding site [nucleotide binding] 1220533011088 sequence specific DNA binding site [nucleotide binding]; other site 1220533011089 putative cAMP binding site [chemical binding]; other site 1220533011090 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1220533011091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011092 putative substrate translocation pore; other site 1220533011093 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1220533011094 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1220533011095 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1220533011096 active site 1220533011097 HIGH motif; other site 1220533011098 KMSK motif region; other site 1220533011099 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1220533011100 tRNA binding surface [nucleotide binding]; other site 1220533011101 anticodon binding site; other site 1220533011102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1220533011103 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 1220533011104 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1220533011105 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1220533011106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533011107 FeS/SAM binding site; other site 1220533011108 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1220533011109 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1220533011110 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1220533011111 Walker A/P-loop; other site 1220533011112 ATP binding site [chemical binding]; other site 1220533011113 Q-loop/lid; other site 1220533011114 ABC transporter signature motif; other site 1220533011115 Walker B; other site 1220533011116 D-loop; other site 1220533011117 H-loop/switch region; other site 1220533011118 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1220533011119 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1220533011120 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1220533011121 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1220533011122 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1220533011123 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1220533011124 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1220533011125 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1220533011126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1220533011127 binding surface 1220533011128 TPR motif; other site 1220533011129 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1220533011130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533011131 TPR motif; other site 1220533011132 binding surface 1220533011133 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533011134 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1220533011135 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1220533011136 putative deacylase active site [active] 1220533011137 agmatinase; Region: agmatinase; TIGR01230 1220533011138 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1220533011139 putative active site [active] 1220533011140 Mn binding site [ion binding]; other site 1220533011141 spermidine synthase; Provisional; Region: PRK00811 1220533011142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533011143 Transglycosylase; Region: Transgly; pfam00912 1220533011144 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1220533011145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1220533011146 YwhD family; Region: YwhD; pfam08741 1220533011147 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1220533011148 Peptidase family M50; Region: Peptidase_M50; pfam02163 1220533011149 active site 1220533011150 putative substrate binding region [chemical binding]; other site 1220533011151 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1220533011152 active site 1 [active] 1220533011153 dimer interface [polypeptide binding]; other site 1220533011154 hexamer interface [polypeptide binding]; other site 1220533011155 active site 2 [active] 1220533011156 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533011157 MarR family; Region: MarR; pfam01047 1220533011158 MarR family; Region: MarR_2; cl17246 1220533011159 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1220533011160 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1220533011161 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1220533011162 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1220533011163 active site 1220533011164 dimer interface [polypeptide binding]; other site 1220533011165 motif 1; other site 1220533011166 motif 2; other site 1220533011167 motif 3; other site 1220533011168 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1220533011169 anticodon binding site; other site 1220533011170 T-box; B657_miscRNA57 1220533011171 T-box; B657_miscRNA58 1220533011172 benzoate transport; Region: 2A0115; TIGR00895 1220533011173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011174 putative substrate translocation pore; other site 1220533011175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011176 Rrf2 family protein; Region: rrf2_super; TIGR00738 1220533011177 Transcriptional regulator; Region: Rrf2; pfam02082 1220533011178 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1220533011179 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1220533011180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1220533011181 Zn2+ binding site [ion binding]; other site 1220533011182 Mg2+ binding site [ion binding]; other site 1220533011183 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1220533011184 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1220533011185 EamA-like transporter family; Region: EamA; pfam00892 1220533011186 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1220533011187 EamA-like transporter family; Region: EamA; pfam00892 1220533011188 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1220533011189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533011190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533011191 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1220533011192 putative dimerization interface [polypeptide binding]; other site 1220533011193 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1220533011194 putative heme peroxidase; Provisional; Region: PRK12276 1220533011195 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1220533011196 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1220533011197 putative NAD(P) binding site [chemical binding]; other site 1220533011198 putative active site [active] 1220533011199 transaminase; Reviewed; Region: PRK08068 1220533011200 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1220533011201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533011202 homodimer interface [polypeptide binding]; other site 1220533011203 catalytic residue [active] 1220533011204 H+ Antiporter protein; Region: 2A0121; TIGR00900 1220533011205 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1220533011206 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1220533011207 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1220533011208 classical (c) SDRs; Region: SDR_c; cd05233 1220533011209 NAD(P) binding site [chemical binding]; other site 1220533011210 active site 1220533011211 Cupin domain; Region: Cupin_2; pfam07883 1220533011212 Cupin domain; Region: Cupin_2; pfam07883 1220533011213 Prephenate dehydratase; Region: PDT; pfam00800 1220533011214 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1220533011215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011216 putative substrate translocation pore; other site 1220533011217 S-methylmethionine transporter; Provisional; Region: PRK11387 1220533011218 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1220533011219 putative metal binding site [ion binding]; other site 1220533011220 putative dimer interface [polypeptide binding]; other site 1220533011221 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1220533011222 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1220533011223 Glutamate binding site [chemical binding]; other site 1220533011224 homodimer interface [polypeptide binding]; other site 1220533011225 NAD binding site [chemical binding]; other site 1220533011226 catalytic residues [active] 1220533011227 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1220533011228 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1220533011229 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1220533011230 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1220533011231 NAD(P) binding site [chemical binding]; other site 1220533011232 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1220533011233 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1220533011234 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1220533011235 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1220533011236 NADP binding site [chemical binding]; other site 1220533011237 active site 1220533011238 putative substrate binding site [chemical binding]; other site 1220533011239 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1220533011240 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1220533011241 NAD binding site [chemical binding]; other site 1220533011242 substrate binding site [chemical binding]; other site 1220533011243 homodimer interface [polypeptide binding]; other site 1220533011244 active site 1220533011245 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1220533011246 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1220533011247 substrate binding site; other site 1220533011248 tetramer interface; other site 1220533011249 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1220533011250 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1220533011251 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1220533011252 ligand binding site; other site 1220533011253 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1220533011254 NeuB family; Region: NeuB; pfam03102 1220533011255 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1220533011256 NeuB binding interface [polypeptide binding]; other site 1220533011257 putative substrate binding site [chemical binding]; other site 1220533011258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1220533011259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533011260 Coenzyme A binding pocket [chemical binding]; other site 1220533011261 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1220533011262 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1220533011263 inhibitor-cofactor binding pocket; inhibition site 1220533011264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533011265 catalytic residue [active] 1220533011266 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1220533011267 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1220533011268 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1220533011269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533011270 active site 1220533011271 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1220533011272 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1220533011273 Permease family; Region: Xan_ur_permease; pfam00860 1220533011274 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1220533011275 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1220533011276 NAD(P) binding site [chemical binding]; other site 1220533011277 catalytic residues [active] 1220533011278 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1220533011279 ligand binding site [chemical binding]; other site 1220533011280 active site 1220533011281 UGI interface [polypeptide binding]; other site 1220533011282 catalytic site [active] 1220533011283 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1220533011284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1220533011285 active site 1220533011286 Predicted transcriptional regulators [Transcription]; Region: COG1695 1220533011287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1220533011288 putative DNA binding site [nucleotide binding]; other site 1220533011289 putative Zn2+ binding site [ion binding]; other site 1220533011290 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1220533011291 dimer interface [polypeptide binding]; other site 1220533011292 substrate binding site [chemical binding]; other site 1220533011293 ATP binding site [chemical binding]; other site 1220533011294 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1220533011295 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1220533011296 substrate binding [chemical binding]; other site 1220533011297 active site 1220533011298 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1220533011299 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1220533011300 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1220533011301 active site turn [active] 1220533011302 phosphorylation site [posttranslational modification] 1220533011303 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1220533011304 formate/nitrite transporter; Region: fnt; TIGR00790 1220533011305 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1220533011306 CAT RNA binding domain; Region: CAT_RBD; smart01061 1220533011307 PRD domain; Region: PRD; pfam00874 1220533011308 PRD domain; Region: PRD; pfam00874 1220533011309 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1220533011310 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1220533011311 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1220533011312 putative active site [active] 1220533011313 catalytic triad [active] 1220533011314 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1220533011315 PA/protease domain interface [polypeptide binding]; other site 1220533011316 putative integrin binding motif; other site 1220533011317 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1220533011318 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1220533011319 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1220533011320 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1220533011321 Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171 1220533011322 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1220533011323 dimer interface [polypeptide binding]; other site 1220533011324 FMN binding site [chemical binding]; other site 1220533011325 NADPH bind site [chemical binding]; other site 1220533011326 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1220533011327 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1220533011328 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1220533011329 Subunit I/III interface [polypeptide binding]; other site 1220533011330 Subunit III/IV interface [polypeptide binding]; other site 1220533011331 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1220533011332 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1220533011333 D-pathway; other site 1220533011334 Putative ubiquinol binding site [chemical binding]; other site 1220533011335 Low-spin heme (heme b) binding site [chemical binding]; other site 1220533011336 Putative water exit pathway; other site 1220533011337 Binuclear center (heme o3/CuB) [ion binding]; other site 1220533011338 K-pathway; other site 1220533011339 Putative proton exit pathway; other site 1220533011340 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1220533011341 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1220533011342 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1220533011343 Predicted membrane protein [Function unknown]; Region: COG2261 1220533011344 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 1220533011345 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1220533011346 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1220533011347 galactokinase; Provisional; Region: PRK05322 1220533011348 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1220533011349 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1220533011350 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1220533011351 Predicted membrane protein [Function unknown]; Region: COG2246 1220533011352 GtrA-like protein; Region: GtrA; pfam04138 1220533011353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533011354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533011355 Anti-repressor SinI; Region: SinI; pfam08671 1220533011356 Predicted membrane protein [Function unknown]; Region: COG3162 1220533011357 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1220533011358 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1220533011359 Na binding site [ion binding]; other site 1220533011360 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1220533011361 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1220533011362 catalytic residues [active] 1220533011363 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1220533011364 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1220533011365 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1220533011366 Imelysin; Region: Peptidase_M75; pfam09375 1220533011367 FTR1 family protein; Region: TIGR00145 1220533011368 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1220533011369 thiamine phosphate binding site [chemical binding]; other site 1220533011370 active site 1220533011371 pyrophosphate binding site [ion binding]; other site 1220533011372 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1220533011373 substrate binding site [chemical binding]; other site 1220533011374 multimerization interface [polypeptide binding]; other site 1220533011375 ATP binding site [chemical binding]; other site 1220533011376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533011377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533011378 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1220533011379 putative dimerization interface [polypeptide binding]; other site 1220533011380 holin-like protein; Validated; Region: PRK01658 1220533011381 TIGR00659 family protein; Region: TIGR00659 1220533011382 sugar efflux transporter; Region: 2A0120; TIGR00899 1220533011383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011384 putative substrate translocation pore; other site 1220533011385 conserved hypothetical protein; Region: TIGR03833 1220533011386 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1220533011387 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1220533011388 putative RNA binding site [nucleotide binding]; other site 1220533011389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533011390 S-adenosylmethionine binding site [chemical binding]; other site 1220533011391 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533011392 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1220533011393 active site 1220533011394 metal binding site [ion binding]; metal-binding site 1220533011395 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1220533011396 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1220533011397 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1220533011398 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1220533011399 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1220533011400 active site 1220533011401 catalytic residues [active] 1220533011402 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1220533011403 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1220533011404 active site turn [active] 1220533011405 phosphorylation site [posttranslational modification] 1220533011406 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1220533011407 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1220533011408 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1220533011409 PRD domain; Region: PRD; pfam00874 1220533011410 PRD domain; Region: PRD; pfam00874 1220533011411 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1220533011412 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1220533011413 Ligand binding site; other site 1220533011414 metal-binding site 1220533011415 Predicted integral membrane protein [Function unknown]; Region: COG5522 1220533011416 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533011417 MarR family; Region: MarR; pfam01047 1220533011418 T-box; B657_miscRNA59 1220533011419 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1220533011420 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1220533011421 active site 1220533011422 HIGH motif; other site 1220533011423 dimer interface [polypeptide binding]; other site 1220533011424 KMSKS motif; other site 1220533011425 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1220533011426 RNA binding surface [nucleotide binding]; other site 1220533011427 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1220533011428 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1220533011429 PA/protease domain interface [polypeptide binding]; other site 1220533011430 putative integrin binding motif; other site 1220533011431 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1220533011432 Peptidase family M28; Region: Peptidase_M28; pfam04389 1220533011433 metal binding site [ion binding]; metal-binding site 1220533011434 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1220533011435 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1220533011436 synthetase active site [active] 1220533011437 NTP binding site [chemical binding]; other site 1220533011438 metal binding site [ion binding]; metal-binding site 1220533011439 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1220533011440 UbiA prenyltransferase family; Region: UbiA; pfam01040 1220533011441 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1220533011442 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 1220533011443 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1220533011444 acyl-activating enzyme (AAE) consensus motif; other site 1220533011445 AMP binding site [chemical binding]; other site 1220533011446 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1220533011447 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1220533011448 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1220533011449 DltD N-terminal region; Region: DltD_N; pfam04915 1220533011450 DltD central region; Region: DltD_M; pfam04918 1220533011451 DltD C-terminal region; Region: DltD_C; pfam04914 1220533011452 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1220533011453 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1220533011454 putative NAD(P) binding site [chemical binding]; other site 1220533011455 active site 1220533011456 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1220533011457 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1220533011458 homodimer interface [polypeptide binding]; other site 1220533011459 substrate-cofactor binding pocket; other site 1220533011460 catalytic residue [active] 1220533011461 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1220533011462 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1220533011463 NAD binding site [chemical binding]; other site 1220533011464 sugar binding site [chemical binding]; other site 1220533011465 divalent metal binding site [ion binding]; other site 1220533011466 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1220533011467 dimer interface [polypeptide binding]; other site 1220533011468 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1220533011469 methionine cluster; other site 1220533011470 active site 1220533011471 phosphorylation site [posttranslational modification] 1220533011472 metal binding site [ion binding]; metal-binding site 1220533011473 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1220533011474 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1220533011475 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1220533011476 active site 1220533011477 P-loop; other site 1220533011478 phosphorylation site [posttranslational modification] 1220533011479 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1220533011480 HTH domain; Region: HTH_11; pfam08279 1220533011481 Mga helix-turn-helix domain; Region: Mga; pfam05043 1220533011482 PRD domain; Region: PRD; pfam00874 1220533011483 PRD domain; Region: PRD; pfam00874 1220533011484 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1220533011485 active site 1220533011486 P-loop; other site 1220533011487 phosphorylation site [posttranslational modification] 1220533011488 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1220533011489 active site 1220533011490 phosphorylation site [posttranslational modification] 1220533011491 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1220533011492 active site 1220533011493 DNA binding site [nucleotide binding] 1220533011494 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1220533011495 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1220533011496 tetramer interface [polypeptide binding]; other site 1220533011497 heme binding pocket [chemical binding]; other site 1220533011498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533011500 putative substrate translocation pore; other site 1220533011501 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1220533011502 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1220533011503 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1220533011504 Walker A/P-loop; other site 1220533011505 ATP binding site [chemical binding]; other site 1220533011506 Q-loop/lid; other site 1220533011507 ABC transporter signature motif; other site 1220533011508 Walker B; other site 1220533011509 D-loop; other site 1220533011510 H-loop/switch region; other site 1220533011511 Exoribonuclease II [Transcription]; Region: Rnb; COG4776 1220533011512 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1220533011513 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1220533011514 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533011515 DNA binding residues [nucleotide binding] 1220533011516 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1220533011517 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1220533011518 Na binding site [ion binding]; other site 1220533011519 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1220533011520 putative substrate binding site [chemical binding]; other site 1220533011521 putative ATP binding site [chemical binding]; other site 1220533011522 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1220533011523 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533011524 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1220533011525 Walker A/P-loop; other site 1220533011526 ATP binding site [chemical binding]; other site 1220533011527 Q-loop/lid; other site 1220533011528 ABC transporter signature motif; other site 1220533011529 Walker B; other site 1220533011530 D-loop; other site 1220533011531 H-loop/switch region; other site 1220533011532 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1220533011533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1220533011534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1220533011535 ATP binding site [chemical binding]; other site 1220533011536 Q-loop/lid; other site 1220533011537 ABC transporter signature motif; other site 1220533011538 Walker B; other site 1220533011539 D-loop; other site 1220533011540 H-loop/switch region; other site 1220533011541 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203 1220533011542 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1220533011543 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1220533011544 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1220533011545 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1220533011546 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1220533011547 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1220533011548 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1220533011549 putative active site [active] 1220533011550 putative metal binding site [ion binding]; other site 1220533011551 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1220533011552 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1220533011553 Walker A/P-loop; other site 1220533011554 ATP binding site [chemical binding]; other site 1220533011555 Q-loop/lid; other site 1220533011556 ABC transporter signature motif; other site 1220533011557 Walker B; other site 1220533011558 D-loop; other site 1220533011559 H-loop/switch region; other site 1220533011560 TOBE domain; Region: TOBE; pfam03459 1220533011561 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1220533011562 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1220533011563 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1220533011564 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1220533011565 NAD(P) binding site [chemical binding]; other site 1220533011566 catalytic residues [active] 1220533011567 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1220533011568 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533011569 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1220533011570 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1220533011571 ykkC-yxkD; B657_miscRNA60 1220533011572 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1220533011573 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1220533011574 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1220533011575 UDP-glucose 4-epimerase; Region: PLN02240 1220533011576 NAD binding site [chemical binding]; other site 1220533011577 homodimer interface [polypeptide binding]; other site 1220533011578 active site 1220533011579 substrate binding site [chemical binding]; other site 1220533011580 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1220533011581 substrate binding site [chemical binding]; other site 1220533011582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533011583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533011584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1220533011585 dimerization interface [polypeptide binding]; other site 1220533011586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1220533011587 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1220533011588 Histidine kinase; Region: HisKA_3; pfam07730 1220533011589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533011590 ATP binding site [chemical binding]; other site 1220533011591 Mg2+ binding site [ion binding]; other site 1220533011592 G-X-G motif; other site 1220533011593 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1220533011594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533011595 active site 1220533011596 phosphorylation site [posttranslational modification] 1220533011597 intermolecular recognition site; other site 1220533011598 dimerization interface [polypeptide binding]; other site 1220533011599 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1220533011600 DNA binding residues [nucleotide binding] 1220533011601 dimerization interface [polypeptide binding]; other site 1220533011602 peptidase T; Region: peptidase-T; TIGR01882 1220533011603 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1220533011604 metal binding site [ion binding]; metal-binding site 1220533011605 dimer interface [polypeptide binding]; other site 1220533011606 Uncharacterized conserved protein [Function unknown]; Region: COG4894 1220533011607 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1220533011608 substrate binding site [chemical binding]; other site 1220533011609 THF binding site; other site 1220533011610 zinc-binding site [ion binding]; other site 1220533011611 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1220533011612 substrate binding site [chemical binding]; other site 1220533011613 THF binding site; other site 1220533011614 zinc-binding site [ion binding]; other site 1220533011615 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1220533011616 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1220533011617 NAD binding site [chemical binding]; other site 1220533011618 homotetramer interface [polypeptide binding]; other site 1220533011619 homodimer interface [polypeptide binding]; other site 1220533011620 substrate binding site [chemical binding]; other site 1220533011621 active site 1220533011622 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1220533011623 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1220533011624 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1220533011625 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1220533011626 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1220533011627 S-adenosylmethionine binding site [chemical binding]; other site 1220533011628 nucleoside transporter; Region: nupC; TIGR00804 1220533011629 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1220533011630 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1220533011631 hydroperoxidase II; Provisional; Region: katE; PRK11249 1220533011632 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1220533011633 tetramer interface [polypeptide binding]; other site 1220533011634 heme binding pocket [chemical binding]; other site 1220533011635 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1220533011636 domain interactions; other site 1220533011637 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1220533011638 Citrate transporter; Region: CitMHS; pfam03600 1220533011639 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1220533011640 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1220533011641 active site 1220533011642 active site 1220533011643 catalytic residues [active] 1220533011644 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1220533011645 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1220533011646 PRD domain; Region: PRD; pfam00874 1220533011647 PRD domain; Region: PRD; pfam00874 1220533011648 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1220533011649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011650 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1220533011651 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1220533011652 ATP binding site [chemical binding]; other site 1220533011653 Mg++ binding site [ion binding]; other site 1220533011654 motif III; other site 1220533011655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1220533011656 nucleotide binding region [chemical binding]; other site 1220533011657 ATP-binding site [chemical binding]; other site 1220533011658 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1220533011659 RNA binding site [nucleotide binding]; other site 1220533011660 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1220533011661 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1220533011662 active site 1220533011663 catalytic triad [active] 1220533011664 YxiJ-like protein; Region: YxiJ; pfam14176 1220533011665 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1220533011666 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1220533011667 RHS Repeat; Region: RHS_repeat; pfam05593 1220533011668 RHS Repeat; Region: RHS_repeat; pfam05593 1220533011669 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1220533011670 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1220533011671 RHS Repeat; Region: RHS_repeat; pfam05593 1220533011672 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1220533011673 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1220533011674 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1220533011675 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1220533011676 EamA-like transporter family; Region: EamA; pfam00892 1220533011677 EamA-like transporter family; Region: EamA; pfam00892 1220533011678 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1220533011679 Ligand Binding Site [chemical binding]; other site 1220533011680 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1220533011681 beta-galactosidase; Region: BGL; TIGR03356 1220533011682 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1220533011683 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1220533011684 active site turn [active] 1220533011685 phosphorylation site [posttranslational modification] 1220533011686 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1220533011687 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1220533011688 HPr interaction site; other site 1220533011689 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1220533011690 active site 1220533011691 phosphorylation site [posttranslational modification] 1220533011692 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1220533011693 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1220533011694 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1220533011695 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1220533011696 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1220533011697 substrate binding site [chemical binding]; other site 1220533011698 active site 1220533011699 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1220533011700 hexamer interface [polypeptide binding]; other site 1220533011701 RNA binding site [nucleotide binding]; other site 1220533011702 Histidine-zinc binding site [chemical binding]; other site 1220533011703 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1220533011704 active sites [active] 1220533011705 tetramer interface [polypeptide binding]; other site 1220533011706 urocanate hydratase; Provisional; Region: PRK05414 1220533011707 imidazolonepropionase; Validated; Region: PRK09356 1220533011708 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1220533011709 active site 1220533011710 Agmatinase-like family; Region: Agmatinase-like; cd09990 1220533011711 agmatinase; Region: agmatinase; TIGR01230 1220533011712 active site 1220533011713 oligomer interface [polypeptide binding]; other site 1220533011714 Mn binding site [ion binding]; other site 1220533011715 S-methylmethionine transporter; Provisional; Region: PRK11387 1220533011716 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1220533011717 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1220533011718 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1220533011719 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1220533011720 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1220533011721 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1220533011722 Nucleoside recognition; Region: Gate; pfam07670 1220533011723 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1220533011724 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1220533011725 intersubunit interface [polypeptide binding]; other site 1220533011726 active site 1220533011727 catalytic residue [active] 1220533011728 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1220533011729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1220533011730 DNA binding residues [nucleotide binding] 1220533011731 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1220533011732 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1220533011733 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1220533011734 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1220533011735 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1220533011736 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 1220533011737 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1220533011738 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1220533011739 metal binding site [ion binding]; metal-binding site 1220533011740 dimer interface [polypeptide binding]; other site 1220533011741 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1220533011742 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1220533011743 Walker A/P-loop; other site 1220533011744 ATP binding site [chemical binding]; other site 1220533011745 Q-loop/lid; other site 1220533011746 ABC transporter signature motif; other site 1220533011747 Walker B; other site 1220533011748 D-loop; other site 1220533011749 H-loop/switch region; other site 1220533011750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1220533011751 dimer interface [polypeptide binding]; other site 1220533011752 conserved gate region; other site 1220533011753 putative PBP binding loops; other site 1220533011754 ABC-ATPase subunit interface; other site 1220533011755 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1220533011756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1220533011757 substrate binding pocket [chemical binding]; other site 1220533011758 membrane-bound complex binding site; other site 1220533011759 hinge residues; other site 1220533011760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533011761 Coenzyme A binding pocket [chemical binding]; other site 1220533011762 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1220533011763 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1220533011764 active site 1220533011765 non-prolyl cis peptide bond; other site 1220533011766 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1220533011767 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1220533011768 active site 1220533011769 sugar phosphate phosphatase; Provisional; Region: PRK10513 1220533011770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533011771 active site 1220533011772 motif I; other site 1220533011773 motif II; other site 1220533011774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1220533011775 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1220533011776 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1220533011777 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1220533011778 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1220533011779 putative ligand binding residues [chemical binding]; other site 1220533011780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1220533011781 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1220533011782 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1220533011783 Walker A/P-loop; other site 1220533011784 ATP binding site [chemical binding]; other site 1220533011785 Q-loop/lid; other site 1220533011786 ABC transporter signature motif; other site 1220533011787 Walker B; other site 1220533011788 D-loop; other site 1220533011789 H-loop/switch region; other site 1220533011790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1220533011791 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1220533011792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533011793 ATP binding site [chemical binding]; other site 1220533011794 Mg2+ binding site [ion binding]; other site 1220533011795 G-X-G motif; other site 1220533011796 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533011797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533011798 active site 1220533011799 phosphorylation site [posttranslational modification] 1220533011800 intermolecular recognition site; other site 1220533011801 dimerization interface [polypeptide binding]; other site 1220533011802 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533011803 DNA binding site [nucleotide binding] 1220533011804 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1220533011805 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1220533011806 intersubunit interface [polypeptide binding]; other site 1220533011807 active site 1220533011808 zinc binding site [ion binding]; other site 1220533011809 Na+ binding site [ion binding]; other site 1220533011810 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1220533011811 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1220533011812 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1220533011813 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1220533011814 DNA interaction; other site 1220533011815 Metal-binding active site; metal-binding site 1220533011816 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1220533011817 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1220533011818 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1220533011819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533011821 putative substrate translocation pore; other site 1220533011822 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1220533011823 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1220533011824 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1220533011825 PYR/PP interface [polypeptide binding]; other site 1220533011826 dimer interface [polypeptide binding]; other site 1220533011827 TPP binding site [chemical binding]; other site 1220533011828 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1220533011829 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1220533011830 TPP-binding site; other site 1220533011831 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1220533011832 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1220533011833 substrate binding site [chemical binding]; other site 1220533011834 ATP binding site [chemical binding]; other site 1220533011835 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1220533011836 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1220533011837 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1220533011838 tetrameric interface [polypeptide binding]; other site 1220533011839 NAD binding site [chemical binding]; other site 1220533011840 catalytic residues [active] 1220533011841 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1220533011842 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1220533011843 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1220533011844 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1220533011845 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1220533011846 active site 1220533011847 catalytic tetrad [active] 1220533011848 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1220533011849 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1220533011850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011851 putative substrate translocation pore; other site 1220533011852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011853 heat shock protein 90; Provisional; Region: PRK05218 1220533011854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533011855 ATP binding site [chemical binding]; other site 1220533011856 Mg2+ binding site [ion binding]; other site 1220533011857 G-X-G motif; other site 1220533011858 short chain dehydrogenase; Validated; Region: PRK08589 1220533011859 classical (c) SDRs; Region: SDR_c; cd05233 1220533011860 NAD(P) binding site [chemical binding]; other site 1220533011861 active site 1220533011862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533011863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533011864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533011865 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1220533011866 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1220533011867 NAD(P) binding site [chemical binding]; other site 1220533011868 catalytic residues [active] 1220533011869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533011870 Coenzyme A binding pocket [chemical binding]; other site 1220533011871 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1220533011872 Cupin-like domain; Region: Cupin_8; pfam13621 1220533011873 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1220533011874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533011875 S-adenosylmethionine binding site [chemical binding]; other site 1220533011876 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1220533011877 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1220533011878 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1220533011879 active site 1220533011880 dimer interface [polypeptide binding]; other site 1220533011881 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1220533011882 Ligand Binding Site [chemical binding]; other site 1220533011883 Molecular Tunnel; other site 1220533011884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533011885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533011886 putative substrate translocation pore; other site 1220533011887 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1220533011888 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1220533011889 active site 1220533011890 Trp docking motif [polypeptide binding]; other site 1220533011891 RDD family; Region: RDD; pfam06271 1220533011892 Predicted membrane protein [Function unknown]; Region: COG2311 1220533011893 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1220533011894 Cupin domain; Region: Cupin_2; pfam07883 1220533011895 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1220533011896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1220533011897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1220533011898 short chain dehydrogenase; Provisional; Region: PRK07109 1220533011899 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1220533011900 putative NAD(P) binding site [chemical binding]; other site 1220533011901 active site 1220533011902 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533011903 MarR family; Region: MarR; pfam01047 1220533011904 LrgA family; Region: LrgA; cl00608 1220533011905 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1220533011906 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1220533011907 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1220533011908 Glycerate kinase family; Region: Gly_kinase; pfam02595 1220533011909 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1220533011910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533011911 DNA-binding site [nucleotide binding]; DNA binding site 1220533011912 FCD domain; Region: FCD; pfam07729 1220533011913 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1220533011914 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1220533011915 N- and C-terminal domain interface [polypeptide binding]; other site 1220533011916 active site 1220533011917 catalytic site [active] 1220533011918 metal binding site [ion binding]; metal-binding site 1220533011919 carbohydrate binding site [chemical binding]; other site 1220533011920 ATP binding site [chemical binding]; other site 1220533011921 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1220533011922 gluconate transporter; Region: gntP; TIGR00791 1220533011923 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 1220533011924 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1220533011925 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1220533011926 peroxiredoxin; Region: AhpC; TIGR03137 1220533011927 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1220533011928 dimer interface [polypeptide binding]; other site 1220533011929 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1220533011930 catalytic triad [active] 1220533011931 peroxidatic and resolving cysteines [active] 1220533011932 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1220533011933 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1220533011934 catalytic residue [active] 1220533011935 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1220533011936 catalytic residues [active] 1220533011937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1220533011938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1220533011939 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1220533011940 beta-galactosidase; Region: BGL; TIGR03356 1220533011941 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1220533011942 HPr interaction site; other site 1220533011943 active site 1220533011944 phosphorylation site [posttranslational modification] 1220533011945 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1220533011946 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1220533011947 DNA-binding site [nucleotide binding]; DNA binding site 1220533011948 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1220533011949 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1220533011950 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1220533011951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1220533011952 Walker A/P-loop; other site 1220533011953 ATP binding site [chemical binding]; other site 1220533011954 Q-loop/lid; other site 1220533011955 ABC transporter signature motif; other site 1220533011956 Walker B; other site 1220533011957 D-loop; other site 1220533011958 H-loop/switch region; other site 1220533011959 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 1220533011960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1220533011961 FeS/SAM binding site; other site 1220533011962 exported signaling peptide, YydF/SAG_2028 family; Region: expor_sig_YdyF; TIGR04077 1220533011963 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 1220533011964 Predicted ATPase [General function prediction only]; Region: COG5293 1220533011965 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 1220533011966 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1220533011967 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1220533011968 putative active site [active] 1220533011969 putative metal binding site [ion binding]; other site 1220533011970 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1220533011971 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1220533011972 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1220533011973 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1220533011974 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1220533011975 NAD binding site [chemical binding]; other site 1220533011976 catalytic Zn binding site [ion binding]; other site 1220533011977 structural Zn binding site [ion binding]; other site 1220533011978 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1220533011979 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1220533011980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533011981 Coenzyme A binding pocket [chemical binding]; other site 1220533011982 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533011983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1220533011984 binding surface 1220533011985 TPR motif; other site 1220533011986 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1220533011987 Arginase family; Region: Arginase; cd09989 1220533011988 agmatinase; Region: agmatinase; TIGR01230 1220533011989 active site 1220533011990 Mn binding site [ion binding]; other site 1220533011991 oligomer interface [polypeptide binding]; other site 1220533011992 S-methylmethionine transporter; Provisional; Region: PRK11387 1220533011993 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1220533011994 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1220533011995 inhibitor-cofactor binding pocket; inhibition site 1220533011996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1220533011997 catalytic residue [active] 1220533011998 PAS domain; Region: PAS; smart00091 1220533011999 PAS domain; Region: PAS_9; pfam13426 1220533012000 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1220533012001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1220533012002 Walker A motif; other site 1220533012003 ATP binding site [chemical binding]; other site 1220533012004 Walker B motif; other site 1220533012005 arginine finger; other site 1220533012006 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1220533012007 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1220533012008 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1220533012009 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1220533012010 protein binding site [polypeptide binding]; other site 1220533012011 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1220533012012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 1220533012013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1220533012014 YycH protein; Region: YycH; pfam07435 1220533012015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1220533012016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1220533012017 dimerization interface [polypeptide binding]; other site 1220533012018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1220533012019 putative active site [active] 1220533012020 heme pocket [chemical binding]; other site 1220533012021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1220533012022 dimer interface [polypeptide binding]; other site 1220533012023 phosphorylation site [posttranslational modification] 1220533012024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1220533012025 ATP binding site [chemical binding]; other site 1220533012026 Mg2+ binding site [ion binding]; other site 1220533012027 G-X-G motif; other site 1220533012028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1220533012029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1220533012030 active site 1220533012031 phosphorylation site [posttranslational modification] 1220533012032 intermolecular recognition site; other site 1220533012033 dimerization interface [polypeptide binding]; other site 1220533012034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1220533012035 DNA binding site [nucleotide binding] 1220533012036 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1220533012037 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1220533012038 GDP-binding site [chemical binding]; other site 1220533012039 ACT binding site; other site 1220533012040 IMP binding site; other site 1220533012041 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533012042 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1220533012043 active site 1220533012044 replicative DNA helicase; Provisional; Region: PRK05748 1220533012045 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1220533012046 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1220533012047 Walker A motif; other site 1220533012048 ATP binding site [chemical binding]; other site 1220533012049 Walker B motif; other site 1220533012050 DNA binding loops [nucleotide binding] 1220533012051 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1220533012052 YycC-like protein; Region: YycC; pfam14174 1220533012053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533012054 cyanate transporter; Region: CynX; TIGR00896 1220533012055 putative substrate translocation pore; other site 1220533012056 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1220533012057 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1220533012058 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1220533012059 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1220533012060 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1220533012061 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1220533012062 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1220533012063 diguanylate cyclase; Region: GGDEF; smart00267 1220533012064 DHH family; Region: DHH; pfam01368 1220533012065 DHHA1 domain; Region: DHHA1; pfam02272 1220533012066 Predicted membrane protein [Function unknown]; Region: COG4241 1220533012067 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1220533012068 Predicted transcriptional regulators [Transcription]; Region: COG1733 1220533012069 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1220533012070 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1220533012071 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1220533012072 DHHA2 domain; Region: DHHA2; pfam02833 1220533012073 ANTAR domain; Region: ANTAR; cl04297 1220533012074 D-galactonate transporter; Region: 2A0114; TIGR00893 1220533012075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533012076 putative substrate translocation pore; other site 1220533012077 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 1220533012078 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 1220533012079 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1220533012080 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1220533012081 Walker A/P-loop; other site 1220533012082 ATP binding site [chemical binding]; other site 1220533012083 Q-loop/lid; other site 1220533012084 ABC transporter signature motif; other site 1220533012085 Walker B; other site 1220533012086 D-loop; other site 1220533012087 H-loop/switch region; other site 1220533012088 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 1220533012089 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1220533012090 SnoaL-like domain; Region: SnoaL_3; pfam13474 1220533012091 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1220533012092 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1220533012093 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1220533012094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533012095 putative substrate translocation pore; other site 1220533012096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1220533012097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1220533012098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1220533012099 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1220533012100 putative dimerization interface [polypeptide binding]; other site 1220533012101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533012102 Coenzyme A binding pocket [chemical binding]; other site 1220533012103 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1220533012104 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1220533012105 MarR family; Region: MarR; pfam01047 1220533012106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533012107 Coenzyme A binding pocket [chemical binding]; other site 1220533012108 Predicted membrane protein [Function unknown]; Region: COG2364 1220533012109 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1220533012110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1220533012111 Coenzyme A binding pocket [chemical binding]; other site 1220533012112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1220533012113 RibD C-terminal domain; Region: RibD_C; cl17279 1220533012114 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1220533012115 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1220533012116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533012117 putative substrate translocation pore; other site 1220533012118 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1220533012119 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1220533012120 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1220533012121 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1220533012122 DNA binding residues [nucleotide binding] 1220533012123 putative dimer interface [polypeptide binding]; other site 1220533012124 EamA-like transporter family; Region: EamA; pfam00892 1220533012125 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1220533012126 EamA-like transporter family; Region: EamA; pfam00892 1220533012127 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1220533012128 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1220533012129 catalytic residues [active] 1220533012130 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1220533012131 CAAX protease self-immunity; Region: Abi; pfam02517 1220533012132 benzoate transport; Region: 2A0115; TIGR00895 1220533012133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533012134 putative substrate translocation pore; other site 1220533012135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1220533012136 maltose O-acetyltransferase; Provisional; Region: PRK10092 1220533012137 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1220533012138 active site 1220533012139 substrate binding site [chemical binding]; other site 1220533012140 trimer interface [polypeptide binding]; other site 1220533012141 CoA binding site [chemical binding]; other site 1220533012142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1220533012143 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1220533012144 putative metal binding site [ion binding]; other site 1220533012145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1220533012146 DNA binding site [nucleotide binding] 1220533012147 domain linker motif; other site 1220533012148 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1220533012149 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1220533012150 putative dimerization interface [polypeptide binding]; other site 1220533012151 putative ligand binding site [chemical binding]; other site 1220533012152 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1220533012153 active site 1220533012154 putative catalytic site [active] 1220533012155 DNA binding site [nucleotide binding] 1220533012156 putative phosphate binding site [ion binding]; other site 1220533012157 metal binding site A [ion binding]; metal-binding site 1220533012158 AP binding site [nucleotide binding]; other site 1220533012159 metal binding site B [ion binding]; metal-binding site 1220533012160 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1220533012161 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1220533012162 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1220533012163 dimer interface [polypeptide binding]; other site 1220533012164 ssDNA binding site [nucleotide binding]; other site 1220533012165 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1220533012166 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1220533012167 GTP-binding protein YchF; Reviewed; Region: PRK09601 1220533012168 YchF GTPase; Region: YchF; cd01900 1220533012169 G1 box; other site 1220533012170 GTP/Mg2+ binding site [chemical binding]; other site 1220533012171 Switch I region; other site 1220533012172 G2 box; other site 1220533012173 Switch II region; other site 1220533012174 G3 box; other site 1220533012175 G4 box; other site 1220533012176 G5 box; other site 1220533012177 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1220533012178 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1220533012179 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1220533012180 putative [4Fe-4S] binding site [ion binding]; other site 1220533012181 putative molybdopterin cofactor binding site [chemical binding]; other site 1220533012182 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1220533012183 molybdopterin cofactor binding site; other site 1220533012184 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1220533012185 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1220533012186 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1220533012187 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1220533012188 ParB-like nuclease domain; Region: ParB; smart00470 1220533012189 KorB domain; Region: KorB; pfam08535 1220533012190 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1220533012191 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1220533012192 P-loop; other site 1220533012193 Magnesium ion binding site [ion binding]; other site 1220533012194 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1220533012195 Magnesium ion binding site [ion binding]; other site 1220533012196 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1220533012197 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1220533012198 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1220533012199 ParB-like nuclease domain; Region: ParB; smart00470 1220533012200 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1220533012201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1220533012202 S-adenosylmethionine binding site [chemical binding]; other site 1220533012203 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1220533012204 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1220533012205 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1220533012206 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1220533012207 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1220533012208 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1220533012209 G1 box; other site 1220533012210 GTP/Mg2+ binding site [chemical binding]; other site 1220533012211 Switch I region; other site 1220533012212 G2 box; other site 1220533012213 Switch II region; other site 1220533012214 G3 box; other site 1220533012215 G4 box; other site 1220533012216 G5 box; other site 1220533012217 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1220533012218 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1220533012219 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1220533012220 G-X-X-G motif; other site 1220533012221 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1220533012222 RxxxH motif; other site 1220533012223 OxaA-like protein precursor; Validated; Region: PRK02944 1220533012224 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1220533012225 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1220533012226 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399