-- dump date 20140618_223621 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1302650000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1302650000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1302650000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650000004 Walker A motif; other site 1302650000005 ATP binding site [chemical binding]; other site 1302650000006 Walker B motif; other site 1302650000007 arginine finger; other site 1302650000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1302650000009 DnaA box-binding interface [nucleotide binding]; other site 1302650000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1302650000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1302650000012 putative DNA binding surface [nucleotide binding]; other site 1302650000013 dimer interface [polypeptide binding]; other site 1302650000014 beta-clamp/clamp loader binding surface; other site 1302650000015 beta-clamp/translesion DNA polymerase binding surface; other site 1302650000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1302650000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1302650000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1302650000019 Walker A/P-loop; other site 1302650000020 ATP binding site [chemical binding]; other site 1302650000021 Q-loop/lid; other site 1302650000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650000023 ABC transporter signature motif; other site 1302650000024 Walker B; other site 1302650000025 D-loop; other site 1302650000026 H-loop/switch region; other site 1302650000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1302650000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650000029 ATP binding site [chemical binding]; other site 1302650000030 Mg2+ binding site [ion binding]; other site 1302650000031 G-X-G motif; other site 1302650000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1302650000033 anchoring element; other site 1302650000034 dimer interface [polypeptide binding]; other site 1302650000035 ATP binding site [chemical binding]; other site 1302650000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1302650000037 active site 1302650000038 putative metal-binding site [ion binding]; other site 1302650000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1302650000040 DNA gyrase subunit A; Validated; Region: PRK05560 1302650000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1302650000042 CAP-like domain; other site 1302650000043 active site 1302650000044 primary dimer interface [polypeptide binding]; other site 1302650000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650000051 YaaC-like Protein; Region: YaaC; pfam14175 1302650000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1302650000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1302650000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1302650000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1302650000056 active site 1302650000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1302650000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1302650000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1302650000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1302650000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1302650000062 active site 1302650000063 multimer interface [polypeptide binding]; other site 1302650000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1302650000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1302650000066 predicted active site [active] 1302650000067 catalytic triad [active] 1302650000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 1302650000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1302650000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1302650000071 dimer interface [polypeptide binding]; other site 1302650000072 active site 1302650000073 motif 1; other site 1302650000074 motif 2; other site 1302650000075 motif 3; other site 1302650000076 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1302650000077 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1302650000078 Substrate-binding site [chemical binding]; other site 1302650000079 Substrate specificity [chemical binding]; other site 1302650000080 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1302650000081 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1302650000082 Substrate-binding site [chemical binding]; other site 1302650000083 Substrate specificity [chemical binding]; other site 1302650000084 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1302650000085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650000087 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1302650000088 active site 1302650000089 Isochorismatase family; Region: Isochorismatase; pfam00857 1302650000090 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1302650000091 catalytic triad [active] 1302650000092 conserved cis-peptide bond; other site 1302650000093 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1302650000094 nucleoside/Zn binding site; other site 1302650000095 dimer interface [polypeptide binding]; other site 1302650000096 catalytic motif [active] 1302650000097 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1302650000098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650000099 Walker A motif; other site 1302650000100 ATP binding site [chemical binding]; other site 1302650000101 Walker B motif; other site 1302650000102 arginine finger; other site 1302650000103 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1302650000104 hypothetical protein; Validated; Region: PRK00153 1302650000105 recombination protein RecR; Reviewed; Region: recR; PRK00076 1302650000106 RecR protein; Region: RecR; pfam02132 1302650000107 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1302650000108 putative active site [active] 1302650000109 putative metal-binding site [ion binding]; other site 1302650000110 tetramer interface [polypeptide binding]; other site 1302650000111 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1302650000112 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 1302650000113 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1302650000114 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1302650000115 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1302650000116 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 1302650000117 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1302650000118 homodimer interface [polypeptide binding]; other site 1302650000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650000120 catalytic residue [active] 1302650000121 thymidylate kinase; Validated; Region: tmk; PRK00698 1302650000122 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1302650000123 TMP-binding site; other site 1302650000124 ATP-binding site [chemical binding]; other site 1302650000125 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1302650000126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 1302650000127 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1302650000128 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1302650000129 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1302650000130 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1302650000131 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1302650000132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650000133 S-adenosylmethionine binding site [chemical binding]; other site 1302650000134 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1302650000135 GIY-YIG motif/motif A; other site 1302650000136 putative active site [active] 1302650000137 putative metal binding site [ion binding]; other site 1302650000138 Predicted methyltransferases [General function prediction only]; Region: COG0313 1302650000139 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1302650000140 putative SAM binding site [chemical binding]; other site 1302650000141 putative homodimer interface [polypeptide binding]; other site 1302650000142 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1302650000143 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1302650000144 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1302650000145 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1302650000146 active site 1302650000147 HIGH motif; other site 1302650000148 KMSKS motif; other site 1302650000149 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1302650000150 tRNA binding surface [nucleotide binding]; other site 1302650000151 anticodon binding site; other site 1302650000152 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1302650000153 dimer interface [polypeptide binding]; other site 1302650000154 putative tRNA-binding site [nucleotide binding]; other site 1302650000155 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1302650000156 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1302650000157 active site 1302650000158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1302650000159 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1302650000160 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1302650000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1302650000162 G5 domain; Region: G5; pfam07501 1302650000163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1302650000164 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1302650000165 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1302650000166 putative active site [active] 1302650000167 putative metal binding site [ion binding]; other site 1302650000168 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1302650000169 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1302650000170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650000171 S-adenosylmethionine binding site [chemical binding]; other site 1302650000172 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1302650000173 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1302650000174 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1302650000175 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1302650000176 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1302650000177 pur operon repressor; Provisional; Region: PRK09213 1302650000178 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1302650000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650000180 active site 1302650000181 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1302650000182 homotrimer interaction site [polypeptide binding]; other site 1302650000183 putative active site [active] 1302650000184 regulatory protein SpoVG; Reviewed; Region: PRK13259 1302650000185 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1302650000186 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1302650000187 Substrate binding site; other site 1302650000188 Mg++ binding site; other site 1302650000189 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1302650000190 active site 1302650000191 substrate binding site [chemical binding]; other site 1302650000192 CoA binding site [chemical binding]; other site 1302650000193 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1302650000194 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1302650000195 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650000196 active site 1302650000197 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1302650000198 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1302650000199 5S rRNA interface [nucleotide binding]; other site 1302650000200 CTC domain interface [polypeptide binding]; other site 1302650000201 L16 interface [polypeptide binding]; other site 1302650000202 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1302650000203 putative active site [active] 1302650000204 catalytic residue [active] 1302650000205 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1302650000206 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1302650000207 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1302650000208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650000209 ATP binding site [chemical binding]; other site 1302650000210 putative Mg++ binding site [ion binding]; other site 1302650000211 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650000212 nucleotide binding region [chemical binding]; other site 1302650000213 ATP-binding site [chemical binding]; other site 1302650000214 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1302650000215 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1302650000216 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1302650000217 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1302650000218 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1302650000219 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1302650000220 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1302650000221 putative SAM binding site [chemical binding]; other site 1302650000222 putative homodimer interface [polypeptide binding]; other site 1302650000223 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1302650000224 homodimer interface [polypeptide binding]; other site 1302650000225 metal binding site [ion binding]; metal-binding site 1302650000226 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1302650000227 homodimer interface [polypeptide binding]; other site 1302650000228 active site 1302650000229 putative chemical substrate binding site [chemical binding]; other site 1302650000230 metal binding site [ion binding]; metal-binding site 1302650000231 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650000232 RNA binding surface [nucleotide binding]; other site 1302650000233 sporulation protein YabP; Region: spore_yabP; TIGR02892 1302650000234 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1302650000235 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1302650000236 Septum formation initiator; Region: DivIC; pfam04977 1302650000237 hypothetical protein; Provisional; Region: PRK08582 1302650000238 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1302650000239 RNA binding site [nucleotide binding]; other site 1302650000240 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1302650000241 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1302650000242 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1302650000243 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1302650000244 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1302650000245 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1302650000246 metal ion-dependent adhesion site (MIDAS); other site 1302650000247 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1302650000248 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1302650000249 active site 1302650000250 ATP binding site [chemical binding]; other site 1302650000251 substrate binding site [chemical binding]; other site 1302650000252 activation loop (A-loop); other site 1302650000253 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1302650000254 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1302650000255 Ligand Binding Site [chemical binding]; other site 1302650000256 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1302650000257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650000258 active site 1302650000259 FtsH Extracellular; Region: FtsH_ext; pfam06480 1302650000260 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1302650000261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650000262 Walker A motif; other site 1302650000263 ATP binding site [chemical binding]; other site 1302650000264 Walker B motif; other site 1302650000265 arginine finger; other site 1302650000266 Peptidase family M41; Region: Peptidase_M41; pfam01434 1302650000267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302650000268 nucleotide binding site [chemical binding]; other site 1302650000269 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1302650000270 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1302650000271 dimerization interface [polypeptide binding]; other site 1302650000272 domain crossover interface; other site 1302650000273 redox-dependent activation switch; other site 1302650000274 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1302650000275 SurA N-terminal domain; Region: SurA_N_3; cl07813 1302650000276 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1302650000277 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1302650000278 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1302650000279 dimer interface [polypeptide binding]; other site 1302650000280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650000281 catalytic residue [active] 1302650000282 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1302650000283 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1302650000284 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1302650000285 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1302650000286 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1302650000287 glutamine binding [chemical binding]; other site 1302650000288 catalytic triad [active] 1302650000289 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1302650000290 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1302650000291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650000292 catalytic residue [active] 1302650000293 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1302650000294 dihydropteroate synthase; Region: DHPS; TIGR01496 1302650000295 substrate binding pocket [chemical binding]; other site 1302650000296 dimer interface [polypeptide binding]; other site 1302650000297 inhibitor binding site; inhibition site 1302650000298 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1302650000299 homooctamer interface [polypeptide binding]; other site 1302650000300 active site 1302650000301 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1302650000302 catalytic center binding site [active] 1302650000303 ATP binding site [chemical binding]; other site 1302650000304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302650000305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650000306 non-specific DNA binding site [nucleotide binding]; other site 1302650000307 salt bridge; other site 1302650000308 sequence-specific DNA binding site [nucleotide binding]; other site 1302650000309 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1302650000310 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1302650000311 FMN binding site [chemical binding]; other site 1302650000312 active site 1302650000313 catalytic residues [active] 1302650000314 substrate binding site [chemical binding]; other site 1302650000315 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1302650000316 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1302650000317 dimer interface [polypeptide binding]; other site 1302650000318 putative anticodon binding site; other site 1302650000319 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1302650000320 motif 1; other site 1302650000321 active site 1302650000322 motif 2; other site 1302650000323 motif 3; other site 1302650000324 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1302650000325 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1302650000326 UvrB/uvrC motif; Region: UVR; pfam02151 1302650000327 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1302650000328 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1302650000329 ADP binding site [chemical binding]; other site 1302650000330 phosphagen binding site; other site 1302650000331 substrate specificity loop; other site 1302650000332 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1302650000333 Clp amino terminal domain; Region: Clp_N; pfam02861 1302650000334 Clp amino terminal domain; Region: Clp_N; pfam02861 1302650000335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650000336 Walker A motif; other site 1302650000337 ATP binding site [chemical binding]; other site 1302650000338 Walker B motif; other site 1302650000339 arginine finger; other site 1302650000340 UvrB/uvrC motif; Region: UVR; pfam02151 1302650000341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650000342 Walker A motif; other site 1302650000343 ATP binding site [chemical binding]; other site 1302650000344 Walker B motif; other site 1302650000345 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1302650000346 DNA repair protein RadA; Provisional; Region: PRK11823 1302650000347 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1302650000348 Walker A motif/ATP binding site; other site 1302650000349 ATP binding site [chemical binding]; other site 1302650000350 Walker B motif; other site 1302650000351 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1302650000352 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1302650000353 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1302650000354 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1302650000355 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1302650000356 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1302650000357 putative active site [active] 1302650000358 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1302650000359 substrate binding site; other site 1302650000360 dimer interface; other site 1302650000361 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1302650000362 homotrimer interaction site [polypeptide binding]; other site 1302650000363 zinc binding site [ion binding]; other site 1302650000364 CDP-binding sites; other site 1302650000365 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1302650000366 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1302650000367 active site 1302650000368 HIGH motif; other site 1302650000369 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1302650000370 active site 1302650000371 KMSKS motif; other site 1302650000372 serine O-acetyltransferase; Region: cysE; TIGR01172 1302650000373 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1302650000374 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1302650000375 trimer interface [polypeptide binding]; other site 1302650000376 active site 1302650000377 substrate binding site [chemical binding]; other site 1302650000378 CoA binding site [chemical binding]; other site 1302650000379 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1302650000380 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1302650000381 active site 1302650000382 HIGH motif; other site 1302650000383 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1302650000384 KMSKS motif; other site 1302650000385 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1302650000386 tRNA binding surface [nucleotide binding]; other site 1302650000387 anticodon binding site; other site 1302650000388 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1302650000389 active site 1302650000390 metal binding site [ion binding]; metal-binding site 1302650000391 dimerization interface [polypeptide binding]; other site 1302650000392 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1302650000393 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1302650000394 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1302650000395 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1302650000396 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1302650000397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650000398 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1302650000399 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1302650000400 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1302650000401 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1302650000402 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1302650000403 putative homodimer interface [polypeptide binding]; other site 1302650000404 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1302650000405 heterodimer interface [polypeptide binding]; other site 1302650000406 homodimer interface [polypeptide binding]; other site 1302650000407 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1302650000408 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1302650000409 23S rRNA interface [nucleotide binding]; other site 1302650000410 L7/L12 interface [polypeptide binding]; other site 1302650000411 putative thiostrepton binding site; other site 1302650000412 L25 interface [polypeptide binding]; other site 1302650000413 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1302650000414 mRNA/rRNA interface [nucleotide binding]; other site 1302650000415 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1302650000416 23S rRNA interface [nucleotide binding]; other site 1302650000417 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1302650000418 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1302650000419 core dimer interface [polypeptide binding]; other site 1302650000420 peripheral dimer interface [polypeptide binding]; other site 1302650000421 L10 interface [polypeptide binding]; other site 1302650000422 L11 interface [polypeptide binding]; other site 1302650000423 putative EF-Tu interaction site [polypeptide binding]; other site 1302650000424 putative EF-G interaction site [polypeptide binding]; other site 1302650000425 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1302650000426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650000427 S-adenosylmethionine binding site [chemical binding]; other site 1302650000428 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1302650000429 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1302650000430 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1302650000431 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1302650000432 RPB1 interaction site [polypeptide binding]; other site 1302650000433 RPB10 interaction site [polypeptide binding]; other site 1302650000434 RPB11 interaction site [polypeptide binding]; other site 1302650000435 RPB3 interaction site [polypeptide binding]; other site 1302650000436 RPB12 interaction site [polypeptide binding]; other site 1302650000437 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1302650000438 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1302650000439 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1302650000440 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1302650000441 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1302650000442 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1302650000443 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1302650000444 G-loop; other site 1302650000445 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1302650000446 DNA binding site [nucleotide binding] 1302650000447 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1302650000448 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1302650000449 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1302650000450 S17 interaction site [polypeptide binding]; other site 1302650000451 S8 interaction site; other site 1302650000452 16S rRNA interaction site [nucleotide binding]; other site 1302650000453 streptomycin interaction site [chemical binding]; other site 1302650000454 23S rRNA interaction site [nucleotide binding]; other site 1302650000455 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1302650000456 30S ribosomal protein S7; Validated; Region: PRK05302 1302650000457 elongation factor G; Reviewed; Region: PRK00007 1302650000458 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1302650000459 G1 box; other site 1302650000460 putative GEF interaction site [polypeptide binding]; other site 1302650000461 GTP/Mg2+ binding site [chemical binding]; other site 1302650000462 Switch I region; other site 1302650000463 G2 box; other site 1302650000464 G3 box; other site 1302650000465 Switch II region; other site 1302650000466 G4 box; other site 1302650000467 G5 box; other site 1302650000468 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1302650000469 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1302650000470 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1302650000471 elongation factor Tu; Reviewed; Region: PRK00049 1302650000472 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1302650000473 G1 box; other site 1302650000474 GEF interaction site [polypeptide binding]; other site 1302650000475 GTP/Mg2+ binding site [chemical binding]; other site 1302650000476 Switch I region; other site 1302650000477 G2 box; other site 1302650000478 G3 box; other site 1302650000479 Switch II region; other site 1302650000480 G4 box; other site 1302650000481 G5 box; other site 1302650000482 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1302650000483 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1302650000484 Antibiotic Binding Site [chemical binding]; other site 1302650000485 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650000486 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1302650000487 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1302650000488 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1302650000489 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1302650000490 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1302650000491 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1302650000492 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1302650000493 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1302650000494 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1302650000495 putative translocon binding site; other site 1302650000496 protein-rRNA interface [nucleotide binding]; other site 1302650000497 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1302650000498 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1302650000499 G-X-X-G motif; other site 1302650000500 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1302650000501 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1302650000502 23S rRNA interface [nucleotide binding]; other site 1302650000503 5S rRNA interface [nucleotide binding]; other site 1302650000504 putative antibiotic binding site [chemical binding]; other site 1302650000505 L25 interface [polypeptide binding]; other site 1302650000506 L27 interface [polypeptide binding]; other site 1302650000507 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1302650000508 23S rRNA interface [nucleotide binding]; other site 1302650000509 putative translocon interaction site; other site 1302650000510 signal recognition particle (SRP54) interaction site; other site 1302650000511 L23 interface [polypeptide binding]; other site 1302650000512 trigger factor interaction site; other site 1302650000513 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1302650000514 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1302650000515 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1302650000516 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1302650000517 RNA binding site [nucleotide binding]; other site 1302650000518 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1302650000519 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1302650000520 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1302650000521 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1302650000522 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1302650000523 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1302650000524 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1302650000525 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1302650000526 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1302650000527 5S rRNA interface [nucleotide binding]; other site 1302650000528 L27 interface [polypeptide binding]; other site 1302650000529 23S rRNA interface [nucleotide binding]; other site 1302650000530 L5 interface [polypeptide binding]; other site 1302650000531 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1302650000532 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1302650000533 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1302650000534 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1302650000535 23S rRNA binding site [nucleotide binding]; other site 1302650000536 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1302650000537 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1302650000538 SecY translocase; Region: SecY; pfam00344 1302650000539 adenylate kinase; Reviewed; Region: adk; PRK00279 1302650000540 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1302650000541 AMP-binding site [chemical binding]; other site 1302650000542 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1302650000543 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1302650000544 active site 1302650000545 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1302650000546 RNA binding site [nucleotide binding]; other site 1302650000547 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1302650000548 rRNA binding site [nucleotide binding]; other site 1302650000549 predicted 30S ribosome binding site; other site 1302650000550 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1302650000551 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1302650000552 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1302650000553 30S ribosomal protein S11; Validated; Region: PRK05309 1302650000554 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1302650000555 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1302650000556 alphaNTD homodimer interface [polypeptide binding]; other site 1302650000557 alphaNTD - beta interaction site [polypeptide binding]; other site 1302650000558 alphaNTD - beta' interaction site [polypeptide binding]; other site 1302650000559 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1302650000560 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1302650000561 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1302650000562 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1302650000563 Walker A/P-loop; other site 1302650000564 ATP binding site [chemical binding]; other site 1302650000565 Q-loop/lid; other site 1302650000566 ABC transporter signature motif; other site 1302650000567 Walker B; other site 1302650000568 D-loop; other site 1302650000569 H-loop/switch region; other site 1302650000570 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1302650000571 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1302650000572 Walker A/P-loop; other site 1302650000573 ATP binding site [chemical binding]; other site 1302650000574 Q-loop/lid; other site 1302650000575 ABC transporter signature motif; other site 1302650000576 Walker B; other site 1302650000577 D-loop; other site 1302650000578 H-loop/switch region; other site 1302650000579 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1302650000580 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1302650000581 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1302650000582 dimerization interface 3.5A [polypeptide binding]; other site 1302650000583 active site 1302650000584 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1302650000585 23S rRNA interface [nucleotide binding]; other site 1302650000586 L3 interface [polypeptide binding]; other site 1302650000587 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1302650000588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650000589 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1302650000590 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1302650000591 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1302650000592 active site 1302650000593 metal binding site [ion binding]; metal-binding site 1302650000594 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1302650000595 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1302650000596 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1302650000597 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1302650000598 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1302650000599 NodB motif; other site 1302650000600 putative active site [active] 1302650000601 putative catalytic site [active] 1302650000602 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1302650000603 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1302650000604 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1302650000605 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1302650000606 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1302650000607 Sodium Bile acid symporter family; Region: SBF; cl17470 1302650000608 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1302650000609 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1302650000610 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650000611 dimer interface [polypeptide binding]; other site 1302650000612 putative PBP binding regions; other site 1302650000613 ABC-ATPase subunit interface; other site 1302650000614 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1302650000615 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1302650000616 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650000617 ABC-ATPase subunit interface; other site 1302650000618 dimer interface [polypeptide binding]; other site 1302650000619 putative PBP binding regions; other site 1302650000620 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1302650000621 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1302650000622 putative ligand binding residues [chemical binding]; other site 1302650000623 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302650000624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650000625 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1302650000626 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1302650000627 putative ligand binding residues [chemical binding]; other site 1302650000628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 1302650000629 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1302650000630 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1302650000631 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1302650000632 putative periplasmic esterase; Provisional; Region: PRK03642 1302650000633 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1302650000634 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1302650000635 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302650000636 active site turn [active] 1302650000637 phosphorylation site [posttranslational modification] 1302650000638 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302650000639 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1302650000640 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1302650000641 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1302650000642 putative active site [active] 1302650000643 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 1302650000644 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1302650000645 putative active site [active] 1302650000646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1302650000647 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1302650000648 potential protein location (hypothetical protein I653_00875 [Bacillus subtilis subsp. subtilis str. BAB-1]) that overlaps RNA (tRNA-Q) 1302650000649 potential protein location (hypothetical protein I653_00875 [Bacillus subtilis subsp. subtilis str. BAB-1]) that overlaps RNA (tRNA-T) 1302650000650 potential protein location (hypothetical protein I653_00875 [Bacillus subtilis subsp. subtilis str. BAB-1]) that overlaps RNA (tRNA-Y) 1302650000651 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1302650000652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650000653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650000654 DNA binding residues [nucleotide binding] 1302650000655 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1302650000656 Putative zinc-finger; Region: zf-HC2; pfam13490 1302650000657 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1302650000658 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1302650000659 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1302650000660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1302650000661 YbbR-like protein; Region: YbbR; pfam07949 1302650000662 YbbR-like protein; Region: YbbR; pfam07949 1302650000663 YbbR-like protein; Region: YbbR; pfam07949 1302650000664 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1302650000665 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1302650000666 active site 1302650000667 substrate binding site [chemical binding]; other site 1302650000668 metal binding site [ion binding]; metal-binding site 1302650000669 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1302650000670 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1302650000671 glutaminase active site [active] 1302650000672 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1302650000673 dimer interface [polypeptide binding]; other site 1302650000674 active site 1302650000675 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1302650000676 dimer interface [polypeptide binding]; other site 1302650000677 active site 1302650000678 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1302650000679 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1302650000680 active site 1302650000681 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1302650000682 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1302650000683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1302650000684 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1302650000685 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1302650000686 zinc binding site [ion binding]; other site 1302650000687 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1302650000688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650000689 dimerization interface [polypeptide binding]; other site 1302650000690 putative DNA binding site [nucleotide binding]; other site 1302650000691 putative Zn2+ binding site [ion binding]; other site 1302650000692 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1302650000693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650000694 putative substrate translocation pore; other site 1302650000695 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1302650000696 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1302650000697 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1302650000698 DNA binding residues [nucleotide binding] 1302650000699 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1302650000700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650000701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650000702 active site 1302650000703 phosphorylation site [posttranslational modification] 1302650000704 intermolecular recognition site; other site 1302650000705 dimerization interface [polypeptide binding]; other site 1302650000706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650000707 DNA binding site [nucleotide binding] 1302650000708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650000709 HAMP domain; Region: HAMP; pfam00672 1302650000710 dimerization interface [polypeptide binding]; other site 1302650000711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650000712 dimer interface [polypeptide binding]; other site 1302650000713 phosphorylation site [posttranslational modification] 1302650000714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650000715 ATP binding site [chemical binding]; other site 1302650000716 Mg2+ binding site [ion binding]; other site 1302650000717 G-X-G motif; other site 1302650000718 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1302650000719 active site 1302650000720 ATP binding site [chemical binding]; other site 1302650000721 substrate binding site [chemical binding]; other site 1302650000722 activation loop (A-loop); other site 1302650000723 putative transport protein YifK; Provisional; Region: PRK10746 1302650000724 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1302650000725 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1302650000726 Cytochrome P450; Region: p450; cl12078 1302650000727 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1302650000728 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1302650000729 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1302650000730 active site 1302650000731 catalytic site [active] 1302650000732 metal binding site [ion binding]; metal-binding site 1302650000733 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1302650000734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650000735 putative substrate translocation pore; other site 1302650000736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650000737 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1302650000738 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650000739 MarR family; Region: MarR; pfam01047 1302650000740 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1302650000741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650000742 Coenzyme A binding pocket [chemical binding]; other site 1302650000743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650000744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650000745 putative substrate translocation pore; other site 1302650000746 EamA-like transporter family; Region: EamA; pfam00892 1302650000747 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1302650000748 EamA-like transporter family; Region: EamA; pfam00892 1302650000749 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1302650000750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650000751 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302650000752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650000753 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1302650000754 LXG domain of WXG superfamily; Region: LXG; pfam04740 1302650000755 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 1302650000756 active site 1302650000757 conformational flexibility of ligand binding pocket; other site 1302650000758 ADP-ribosylating toxin turn-turn motif; other site 1302650000759 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1302650000760 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1302650000761 ATP-grasp domain; Region: ATP-grasp; pfam02222 1302650000762 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1302650000763 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1302650000764 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650000765 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1302650000766 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1302650000767 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1302650000768 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1302650000769 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1302650000770 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1302650000771 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1302650000772 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1302650000773 active site residue [active] 1302650000774 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1302650000775 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1302650000776 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1302650000777 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302650000778 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1302650000779 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302650000780 active site turn [active] 1302650000781 phosphorylation site [posttranslational modification] 1302650000782 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1302650000783 HPr interaction site; other site 1302650000784 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1302650000785 active site 1302650000786 phosphorylation site [posttranslational modification] 1302650000787 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1302650000788 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1302650000789 active site 1302650000790 trimer interface [polypeptide binding]; other site 1302650000791 allosteric site; other site 1302650000792 active site lid [active] 1302650000793 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1302650000794 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1302650000795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650000796 DNA-binding site [nucleotide binding]; DNA binding site 1302650000797 UTRA domain; Region: UTRA; pfam07702 1302650000798 Predicted integral membrane protein [Function unknown]; Region: COG5658 1302650000799 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1302650000800 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1302650000801 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1302650000802 homodimer interface [polypeptide binding]; other site 1302650000803 substrate-cofactor binding pocket; other site 1302650000804 catalytic residue [active] 1302650000805 S-methylmethionine transporter; Provisional; Region: PRK11387 1302650000806 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1302650000807 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1302650000808 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1302650000809 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1302650000810 glutaminase; Reviewed; Region: PRK12357 1302650000811 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1302650000812 Chorismate mutase type II; Region: CM_2; cl00693 1302650000813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650000814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650000815 ATP binding site [chemical binding]; other site 1302650000816 Mg2+ binding site [ion binding]; other site 1302650000817 G-X-G motif; other site 1302650000818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650000819 Response regulator receiver domain; Region: Response_reg; pfam00072 1302650000820 active site 1302650000821 phosphorylation site [posttranslational modification] 1302650000822 intermolecular recognition site; other site 1302650000823 dimerization interface [polypeptide binding]; other site 1302650000824 YcbB domain; Region: YcbB; pfam08664 1302650000825 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1302650000826 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1302650000827 putative active site [active] 1302650000828 catalytic residue [active] 1302650000829 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1302650000830 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1302650000831 NAD(P) binding site [chemical binding]; other site 1302650000832 catalytic residues [active] 1302650000833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650000834 D-galactonate transporter; Region: 2A0114; TIGR00893 1302650000835 putative substrate translocation pore; other site 1302650000836 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1302650000837 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1302650000838 active site 1302650000839 tetramer interface [polypeptide binding]; other site 1302650000840 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1302650000841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650000842 DNA-binding site [nucleotide binding]; DNA binding site 1302650000843 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1302650000844 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1302650000845 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1302650000846 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1302650000847 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1302650000848 putative active site [active] 1302650000849 putative substrate binding site [chemical binding]; other site 1302650000850 Phosphotransferase enzyme family; Region: APH; pfam01636 1302650000851 ATP binding site [chemical binding]; other site 1302650000852 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1302650000853 dodecamer interface 1 [polypeptide binding]; other site 1302650000854 dodecamer interface 2 [polypeptide binding]; other site 1302650000855 trimer interface [polypeptide binding]; other site 1302650000856 TRAP binding interface [polypeptide binding]; other site 1302650000857 Zn binding site [ion binding]; other site 1302650000858 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1302650000859 EamA-like transporter family; Region: EamA; pfam00892 1302650000860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650000861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650000862 active site 1302650000863 phosphorylation site [posttranslational modification] 1302650000864 intermolecular recognition site; other site 1302650000865 dimerization interface [polypeptide binding]; other site 1302650000866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650000867 DNA binding site [nucleotide binding] 1302650000868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650000869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650000870 dimer interface [polypeptide binding]; other site 1302650000871 phosphorylation site [posttranslational modification] 1302650000872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650000873 ATP binding site [chemical binding]; other site 1302650000874 Mg2+ binding site [ion binding]; other site 1302650000875 G-X-G motif; other site 1302650000876 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302650000877 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1302650000878 Walker A/P-loop; other site 1302650000879 ATP binding site [chemical binding]; other site 1302650000880 Q-loop/lid; other site 1302650000881 ABC transporter signature motif; other site 1302650000882 Walker B; other site 1302650000883 D-loop; other site 1302650000884 H-loop/switch region; other site 1302650000885 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1302650000886 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1302650000887 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1302650000888 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1302650000889 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1302650000890 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1302650000891 metal ion-dependent adhesion site (MIDAS); other site 1302650000892 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1302650000893 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1302650000894 putative active site [active] 1302650000895 putative metal binding site [ion binding]; other site 1302650000896 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1302650000897 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1302650000898 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1302650000899 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1302650000900 putative substrate binding pocket [chemical binding]; other site 1302650000901 AC domain interface; other site 1302650000902 catalytic triad [active] 1302650000903 AB domain interface; other site 1302650000904 interchain disulfide; other site 1302650000905 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1302650000906 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1302650000907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302650000908 catalytic residue [active] 1302650000909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650000910 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650000911 putative substrate translocation pore; other site 1302650000912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650000913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650000914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650000915 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1302650000916 active site 1302650000917 homotetramer interface [polypeptide binding]; other site 1302650000918 homodimer interface [polypeptide binding]; other site 1302650000919 Lipase (class 2); Region: Lipase_2; pfam01674 1302650000920 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1302650000921 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1302650000922 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1302650000923 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1302650000924 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1302650000925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650000926 ATP binding site [chemical binding]; other site 1302650000927 Mg2+ binding site [ion binding]; other site 1302650000928 G-X-G motif; other site 1302650000929 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1302650000930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650000931 active site 1302650000932 phosphorylation site [posttranslational modification] 1302650000933 intermolecular recognition site; other site 1302650000934 dimerization interface [polypeptide binding]; other site 1302650000935 LytTr DNA-binding domain; Region: LytTR; pfam04397 1302650000936 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1302650000937 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 1302650000938 Walker A/P-loop; other site 1302650000939 ATP binding site [chemical binding]; other site 1302650000940 Q-loop/lid; other site 1302650000941 ABC transporter signature motif; other site 1302650000942 Walker B; other site 1302650000943 D-loop; other site 1302650000944 H-loop/switch region; other site 1302650000945 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1302650000946 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1302650000947 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302650000948 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302650000949 active site 1302650000950 catalytic tetrad [active] 1302650000951 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1302650000952 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1302650000953 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1302650000954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1302650000955 binding surface 1302650000956 TPR motif; other site 1302650000957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650000958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650000959 binding surface 1302650000960 TPR motif; other site 1302650000961 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1302650000962 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1302650000963 NAD binding site [chemical binding]; other site 1302650000964 homodimer interface [polypeptide binding]; other site 1302650000965 active site 1302650000966 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1302650000967 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1302650000968 Ca binding site [ion binding]; other site 1302650000969 active site 1302650000970 catalytic site [active] 1302650000971 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1302650000972 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1302650000973 metal binding site [ion binding]; metal-binding site 1302650000974 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1302650000975 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1302650000976 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1302650000977 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650000978 ABC-ATPase subunit interface; other site 1302650000979 dimer interface [polypeptide binding]; other site 1302650000980 putative PBP binding regions; other site 1302650000981 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1302650000982 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1302650000983 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1302650000984 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1302650000985 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1302650000986 putative metal binding site [ion binding]; other site 1302650000987 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1302650000988 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1302650000989 putative metal binding site [ion binding]; other site 1302650000990 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1302650000991 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1302650000992 putative metal binding site [ion binding]; other site 1302650000993 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1302650000994 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1302650000995 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1302650000996 benzoate transport; Region: 2A0115; TIGR00895 1302650000997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650000998 putative substrate translocation pore; other site 1302650000999 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1302650001000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001001 putative substrate translocation pore; other site 1302650001002 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650001003 dimerization interface [polypeptide binding]; other site 1302650001004 putative DNA binding site [nucleotide binding]; other site 1302650001005 putative Zn2+ binding site [ion binding]; other site 1302650001006 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1302650001007 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1302650001008 Walker A/P-loop; other site 1302650001009 ATP binding site [chemical binding]; other site 1302650001010 Q-loop/lid; other site 1302650001011 ABC transporter signature motif; other site 1302650001012 Walker B; other site 1302650001013 D-loop; other site 1302650001014 H-loop/switch region; other site 1302650001015 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1302650001016 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1302650001017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650001018 dimer interface [polypeptide binding]; other site 1302650001019 conserved gate region; other site 1302650001020 putative PBP binding loops; other site 1302650001021 ABC-ATPase subunit interface; other site 1302650001022 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1302650001023 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1302650001024 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1302650001025 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1302650001026 amidohydrolase; Region: amidohydrolases; TIGR01891 1302650001027 metal binding site [ion binding]; metal-binding site 1302650001028 putative dimer interface [polypeptide binding]; other site 1302650001029 Predicted membrane protein [Function unknown]; Region: COG1288 1302650001030 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1302650001031 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1302650001032 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1302650001033 active site 1302650001034 Ca binding site [ion binding]; other site 1302650001035 catalytic site [active] 1302650001036 Aamy_C domain; Region: Aamy_C; smart00632 1302650001037 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1302650001038 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1302650001039 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302650001040 NAD binding site [chemical binding]; other site 1302650001041 dimer interface [polypeptide binding]; other site 1302650001042 substrate binding site [chemical binding]; other site 1302650001043 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1302650001044 L-lactate permease; Region: Lactate_perm; pfam02652 1302650001045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001046 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650001047 putative substrate translocation pore; other site 1302650001048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001049 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650001050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650001051 putative DNA binding site [nucleotide binding]; other site 1302650001052 putative Zn2+ binding site [ion binding]; other site 1302650001053 LysE type translocator; Region: LysE; pfam01810 1302650001054 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1302650001055 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1302650001056 Spore germination protein; Region: Spore_permease; cl17796 1302650001057 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1302650001058 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1302650001059 NAD+ synthetase; Region: nadE; TIGR00552 1302650001060 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1302650001061 homodimer interface [polypeptide binding]; other site 1302650001062 NAD binding pocket [chemical binding]; other site 1302650001063 ATP binding pocket [chemical binding]; other site 1302650001064 Mg binding site [ion binding]; other site 1302650001065 active-site loop [active] 1302650001066 AAA domain; Region: AAA_17; cl17253 1302650001067 AAA domain; Region: AAA_18; pfam13238 1302650001068 shikimate kinase; Reviewed; Region: aroK; PRK00131 1302650001069 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1302650001070 ADP binding site [chemical binding]; other site 1302650001071 magnesium binding site [ion binding]; other site 1302650001072 putative shikimate binding site; other site 1302650001073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650001074 S-adenosylmethionine binding site [chemical binding]; other site 1302650001075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650001076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650001077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302650001078 dimerization interface [polypeptide binding]; other site 1302650001079 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1302650001080 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1302650001081 Proline dehydrogenase; Region: Pro_dh; pfam01619 1302650001082 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1302650001083 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1302650001084 Glutamate binding site [chemical binding]; other site 1302650001085 homodimer interface [polypeptide binding]; other site 1302650001086 NAD binding site [chemical binding]; other site 1302650001087 catalytic residues [active] 1302650001088 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1302650001089 Na binding site [ion binding]; other site 1302650001090 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1302650001091 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1302650001092 Predicted membrane protein [Function unknown]; Region: COG3689 1302650001093 Predicted permeases [General function prediction only]; Region: COG0701 1302650001094 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650001095 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1302650001096 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1302650001097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650001098 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1302650001099 active site 1302650001100 SAM binding site [chemical binding]; other site 1302650001101 homodimer interface [polypeptide binding]; other site 1302650001102 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1302650001103 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1302650001104 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1302650001105 [2Fe-2S] cluster binding site [ion binding]; other site 1302650001106 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1302650001107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650001108 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1302650001109 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1302650001110 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1302650001111 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1302650001112 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1302650001113 [4Fe-4S] binding site [ion binding]; other site 1302650001114 molybdopterin cofactor binding site; other site 1302650001115 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1302650001116 molybdopterin cofactor binding site; other site 1302650001117 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1302650001118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650001119 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1302650001120 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1302650001121 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1302650001122 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1302650001123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001124 putative substrate translocation pore; other site 1302650001125 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1302650001126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1302650001127 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1302650001128 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1302650001129 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1302650001130 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1302650001131 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1302650001132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650001133 dimer interface [polypeptide binding]; other site 1302650001134 conserved gate region; other site 1302650001135 putative PBP binding loops; other site 1302650001136 ABC-ATPase subunit interface; other site 1302650001137 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302650001138 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302650001139 substrate binding pocket [chemical binding]; other site 1302650001140 membrane-bound complex binding site; other site 1302650001141 hinge residues; other site 1302650001142 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1302650001143 RDD family; Region: RDD; pfam06271 1302650001144 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1302650001145 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1302650001146 beta-galactosidase; Region: BGL; TIGR03356 1302650001147 Competence protein J (ComJ); Region: ComJ; pfam11033 1302650001148 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1302650001149 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650001150 dimerization interface [polypeptide binding]; other site 1302650001151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650001152 dimer interface [polypeptide binding]; other site 1302650001153 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1302650001154 putative CheW interface [polypeptide binding]; other site 1302650001155 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1302650001156 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1302650001157 tetramer interface [polypeptide binding]; other site 1302650001158 active site 1302650001159 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1302650001160 active site 1302650001161 dimer interface [polypeptide binding]; other site 1302650001162 magnesium binding site [ion binding]; other site 1302650001163 Predicted transcriptional regulators [Transcription]; Region: COG1733 1302650001164 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1302650001165 potential frameshift: common BLAST hit: gi|321314020|ref|YP_004206307.1| surfactin synthetase 1302650001166 potential frameshift: common BLAST hit: gi|255767105|ref|NP_388230.2| surfactin synthetase 1302650001167 potential frameshift: common BLAST hit: gi|402774590|ref|YP_006628534.1| surfactin synthetase 1302650001168 Condensation domain; Region: Condensation; pfam00668 1302650001169 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650001170 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1302650001171 acyl-activating enzyme (AAE) consensus motif; other site 1302650001172 AMP binding site [chemical binding]; other site 1302650001173 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650001174 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1302650001175 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1302650001176 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1302650001177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650001179 putative substrate translocation pore; other site 1302650001180 YcxB-like protein; Region: YcxB; pfam14317 1302650001181 EamA-like transporter family; Region: EamA; pfam00892 1302650001182 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1302650001183 EamA-like transporter family; Region: EamA; pfam00892 1302650001184 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1302650001185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650001186 DNA-binding site [nucleotide binding]; DNA binding site 1302650001187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650001188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650001189 homodimer interface [polypeptide binding]; other site 1302650001190 catalytic residue [active] 1302650001191 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1302650001192 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1302650001193 Predicted membrane protein [Function unknown]; Region: COG2364 1302650001194 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650001195 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302650001196 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1302650001197 Walker A/P-loop; other site 1302650001198 ATP binding site [chemical binding]; other site 1302650001199 Q-loop/lid; other site 1302650001200 ABC transporter signature motif; other site 1302650001201 Walker B; other site 1302650001202 D-loop; other site 1302650001203 H-loop/switch region; other site 1302650001204 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1302650001205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650001206 dimer interface [polypeptide binding]; other site 1302650001207 conserved gate region; other site 1302650001208 putative PBP binding loops; other site 1302650001209 ABC-ATPase subunit interface; other site 1302650001210 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302650001211 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302650001212 substrate binding pocket [chemical binding]; other site 1302650001213 membrane-bound complex binding site; other site 1302650001214 hinge residues; other site 1302650001215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650001216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650001217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302650001218 dimerization interface [polypeptide binding]; other site 1302650001219 Flavoprotein; Region: Flavoprotein; pfam02441 1302650001220 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 1302650001221 UbiD family decarboxylase; Region: TIGR00148 1302650001222 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1302650001223 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650001224 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1302650001225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001226 putative substrate translocation pore; other site 1302650001227 POT family; Region: PTR2; pfam00854 1302650001228 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1302650001229 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1302650001230 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1302650001231 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1302650001232 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1302650001233 Spore germination protein; Region: Spore_permease; pfam03845 1302650001234 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302650001235 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302650001236 Walker A/P-loop; other site 1302650001237 ATP binding site [chemical binding]; other site 1302650001238 Q-loop/lid; other site 1302650001239 ABC transporter signature motif; other site 1302650001240 Walker B; other site 1302650001241 D-loop; other site 1302650001242 H-loop/switch region; other site 1302650001243 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1302650001244 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302650001245 FtsX-like permease family; Region: FtsX; pfam02687 1302650001246 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650001247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650001248 active site 1302650001249 phosphorylation site [posttranslational modification] 1302650001250 intermolecular recognition site; other site 1302650001251 dimerization interface [polypeptide binding]; other site 1302650001252 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650001253 DNA binding site [nucleotide binding] 1302650001254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650001255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650001256 dimerization interface [polypeptide binding]; other site 1302650001257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650001258 dimer interface [polypeptide binding]; other site 1302650001259 phosphorylation site [posttranslational modification] 1302650001260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650001261 ATP binding site [chemical binding]; other site 1302650001262 Mg2+ binding site [ion binding]; other site 1302650001263 G-X-G motif; other site 1302650001264 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650001265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650001266 TPR motif; other site 1302650001267 binding surface 1302650001268 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650001269 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1302650001270 aspartate kinase; Reviewed; Region: PRK09034 1302650001271 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1302650001272 putative catalytic residues [active] 1302650001273 putative nucleotide binding site [chemical binding]; other site 1302650001274 putative aspartate binding site [chemical binding]; other site 1302650001275 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1302650001276 allosteric regulatory residue; other site 1302650001277 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1302650001278 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1302650001279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650001280 ABC-ATPase subunit interface; other site 1302650001281 dimer interface [polypeptide binding]; other site 1302650001282 putative PBP binding regions; other site 1302650001283 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650001284 ABC-ATPase subunit interface; other site 1302650001285 dimer interface [polypeptide binding]; other site 1302650001286 putative PBP binding regions; other site 1302650001287 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1302650001288 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1302650001289 Walker A/P-loop; other site 1302650001290 ATP binding site [chemical binding]; other site 1302650001291 Q-loop/lid; other site 1302650001292 ABC transporter signature motif; other site 1302650001293 Walker B; other site 1302650001294 D-loop; other site 1302650001295 H-loop/switch region; other site 1302650001296 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1302650001297 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1302650001298 putative ligand binding residues [chemical binding]; other site 1302650001299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650001301 putative substrate translocation pore; other site 1302650001302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650001304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650001305 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1302650001306 dimer interface [polypeptide binding]; other site 1302650001307 FMN binding site [chemical binding]; other site 1302650001308 NADPH bind site [chemical binding]; other site 1302650001309 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1302650001310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650001311 dimerization interface [polypeptide binding]; other site 1302650001312 putative DNA binding site [nucleotide binding]; other site 1302650001313 putative Zn2+ binding site [ion binding]; other site 1302650001314 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1302650001315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650001316 DNA-binding site [nucleotide binding]; DNA binding site 1302650001317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650001318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650001319 homodimer interface [polypeptide binding]; other site 1302650001320 catalytic residue [active] 1302650001321 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1302650001322 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1302650001323 inhibitor-cofactor binding pocket; inhibition site 1302650001324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650001325 catalytic residue [active] 1302650001326 succinic semialdehyde dehydrogenase; Region: PLN02278 1302650001327 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1302650001328 tetramerization interface [polypeptide binding]; other site 1302650001329 NAD(P) binding site [chemical binding]; other site 1302650001330 catalytic residues [active] 1302650001331 Sugar transport protein; Region: Sugar_transport; pfam06800 1302650001332 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1302650001333 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1302650001334 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1302650001335 NAD binding site [chemical binding]; other site 1302650001336 homodimer interface [polypeptide binding]; other site 1302650001337 active site 1302650001338 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1302650001339 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1302650001340 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1302650001341 YtkA-like; Region: YtkA; pfam13115 1302650001342 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1302650001343 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1302650001344 NosL; Region: NosL; cl01769 1302650001345 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1302650001346 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1302650001347 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1302650001348 active site 1302650001349 P-loop; other site 1302650001350 phosphorylation site [posttranslational modification] 1302650001351 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1302650001352 active site 1302650001353 phosphorylation site [posttranslational modification] 1302650001354 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1302650001355 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1302650001356 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1302650001357 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1302650001358 tartrate dehydrogenase; Provisional; Region: PRK08194 1302650001359 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1302650001360 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1302650001361 Catalytic site [active] 1302650001362 Dienelactone hydrolase family; Region: DLH; pfam01738 1302650001363 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1302650001364 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1302650001365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650001366 active site 1302650001367 motif I; other site 1302650001368 motif II; other site 1302650001369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650001370 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1302650001371 putative active site [active] 1302650001372 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1302650001373 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1302650001374 hypothetical protein; Provisional; Region: PRK05463 1302650001375 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1302650001376 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1302650001377 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1302650001378 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1302650001379 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1302650001380 Bacterial transcriptional regulator; Region: IclR; pfam01614 1302650001381 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 1302650001382 active site 1302650001383 catalytic triad [active] 1302650001384 oxyanion hole [active] 1302650001385 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1302650001386 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1302650001387 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1302650001388 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1302650001389 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302650001390 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302650001391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302650001392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302650001393 active site 1302650001394 catalytic tetrad [active] 1302650001395 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1302650001396 HTH domain; Region: HTH_11; pfam08279 1302650001397 PRD domain; Region: PRD; pfam00874 1302650001398 PRD domain; Region: PRD; pfam00874 1302650001399 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1302650001400 active site 1302650001401 P-loop; other site 1302650001402 phosphorylation site [posttranslational modification] 1302650001403 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1302650001404 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1302650001405 acyl-activating enzyme (AAE) consensus motif; other site 1302650001406 putative AMP binding site [chemical binding]; other site 1302650001407 putative active site [active] 1302650001408 putative CoA binding site [chemical binding]; other site 1302650001409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650001410 S-adenosylmethionine binding site [chemical binding]; other site 1302650001411 short chain dehydrogenase; Provisional; Region: PRK06701 1302650001412 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1302650001413 NAD binding site [chemical binding]; other site 1302650001414 metal binding site [ion binding]; metal-binding site 1302650001415 active site 1302650001416 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1302650001417 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1302650001418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1302650001419 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1302650001420 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1302650001421 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1302650001422 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1302650001423 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1302650001424 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1302650001425 putative DNA binding site [nucleotide binding]; other site 1302650001426 putative Zn2+ binding site [ion binding]; other site 1302650001427 AsnC family; Region: AsnC_trans_reg; pfam01037 1302650001428 DNA topoisomerase III; Provisional; Region: PRK07726 1302650001429 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1302650001430 active site 1302650001431 putative interdomain interaction site [polypeptide binding]; other site 1302650001432 putative metal-binding site [ion binding]; other site 1302650001433 putative nucleotide binding site [chemical binding]; other site 1302650001434 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1302650001435 domain I; other site 1302650001436 DNA binding groove [nucleotide binding] 1302650001437 phosphate binding site [ion binding]; other site 1302650001438 domain II; other site 1302650001439 domain III; other site 1302650001440 nucleotide binding site [chemical binding]; other site 1302650001441 catalytic site [active] 1302650001442 domain IV; other site 1302650001443 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1302650001444 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1302650001445 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1302650001446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1302650001447 metal binding site [ion binding]; metal-binding site 1302650001448 active site 1302650001449 I-site; other site 1302650001450 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1302650001451 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1302650001452 NodB motif; other site 1302650001453 putative active site [active] 1302650001454 putative catalytic site [active] 1302650001455 putative Zn binding site [ion binding]; other site 1302650001456 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1302650001457 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1302650001458 DXD motif; other site 1302650001459 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1302650001460 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1302650001461 Amino acid permease; Region: AA_permease_2; pfam13520 1302650001462 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1302650001463 nudix motif; other site 1302650001464 pyruvate oxidase; Provisional; Region: PRK08611 1302650001465 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1302650001466 PYR/PP interface [polypeptide binding]; other site 1302650001467 tetramer interface [polypeptide binding]; other site 1302650001468 dimer interface [polypeptide binding]; other site 1302650001469 TPP binding site [chemical binding]; other site 1302650001470 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1302650001471 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1302650001472 TPP-binding site [chemical binding]; other site 1302650001473 manganese transport protein MntH; Reviewed; Region: PRK00701 1302650001474 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1302650001475 Predicted membrane protein [Function unknown]; Region: COG2261 1302650001476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1302650001477 EcsC protein family; Region: EcsC; pfam12787 1302650001478 General stress protein [General function prediction only]; Region: GsiB; COG3729 1302650001479 General stress protein [General function prediction only]; Region: GsiB; COG3729 1302650001480 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1302650001481 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1302650001482 dimanganese center [ion binding]; other site 1302650001483 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1302650001484 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1302650001485 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1302650001486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650001487 putative active site [active] 1302650001488 heme pocket [chemical binding]; other site 1302650001489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650001490 ATP binding site [chemical binding]; other site 1302650001491 Mg2+ binding site [ion binding]; other site 1302650001492 G-X-G motif; other site 1302650001493 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1302650001494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650001495 active site 1302650001496 phosphorylation site [posttranslational modification] 1302650001497 intermolecular recognition site; other site 1302650001498 dimerization interface [polypeptide binding]; other site 1302650001499 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1302650001500 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1302650001501 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1302650001502 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1302650001503 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1302650001504 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302650001505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650001506 Walker A/P-loop; other site 1302650001507 ATP binding site [chemical binding]; other site 1302650001508 Q-loop/lid; other site 1302650001509 ABC transporter signature motif; other site 1302650001510 Walker B; other site 1302650001511 D-loop; other site 1302650001512 H-loop/switch region; other site 1302650001513 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1302650001514 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1302650001515 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1302650001516 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1302650001517 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1302650001518 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1302650001519 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1302650001520 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1302650001521 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1302650001522 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302650001523 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302650001524 catalytic residues [active] 1302650001525 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1302650001526 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1302650001527 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1302650001528 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1302650001529 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1302650001530 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302650001531 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302650001532 helicase 45; Provisional; Region: PTZ00424 1302650001533 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1302650001534 ATP binding site [chemical binding]; other site 1302650001535 Mg++ binding site [ion binding]; other site 1302650001536 motif III; other site 1302650001537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650001538 nucleotide binding region [chemical binding]; other site 1302650001539 ATP-binding site [chemical binding]; other site 1302650001540 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1302650001541 Predicted membrane protein [Function unknown]; Region: COG3428 1302650001542 Bacterial PH domain; Region: DUF304; pfam03703 1302650001543 Bacterial PH domain; Region: DUF304; pfam03703 1302650001544 Bacterial PH domain; Region: DUF304; pfam03703 1302650001545 Rhomboid family; Region: Rhomboid; pfam01694 1302650001546 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1302650001547 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1302650001548 alanine racemase; Region: alr; TIGR00492 1302650001549 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1302650001550 active site 1302650001551 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1302650001552 dimer interface [polypeptide binding]; other site 1302650001553 substrate binding site [chemical binding]; other site 1302650001554 catalytic residues [active] 1302650001555 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1302650001556 ribbon-helix-helix domain containing protein; Region: PHA00617 1302650001557 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1302650001558 Rsbr N terminal; Region: Rsbr_N; pfam08678 1302650001559 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1302650001560 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1302650001561 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1302650001562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650001563 ATP binding site [chemical binding]; other site 1302650001564 Mg2+ binding site [ion binding]; other site 1302650001565 G-X-G motif; other site 1302650001566 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1302650001567 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1302650001568 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1302650001569 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1302650001570 anti sigma factor interaction site; other site 1302650001571 regulatory phosphorylation site [posttranslational modification]; other site 1302650001572 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1302650001573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650001574 ATP binding site [chemical binding]; other site 1302650001575 Mg2+ binding site [ion binding]; other site 1302650001576 G-X-G motif; other site 1302650001577 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1302650001578 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650001579 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1302650001580 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650001581 DNA binding residues [nucleotide binding] 1302650001582 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1302650001583 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1302650001584 hydrophobic ligand binding site; other site 1302650001585 hypothetical protein; Provisional; Region: PRK02268 1302650001586 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650001587 MarR family; Region: MarR; pfam01047 1302650001588 MarR family; Region: MarR_2; cl17246 1302650001589 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1302650001590 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1302650001591 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1302650001592 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1302650001593 RNA binding site [nucleotide binding]; other site 1302650001594 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1302650001595 hypothetical protein; Provisional; Region: PRK04351 1302650001596 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1302650001597 active site 1302650001598 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1302650001599 active site 1302650001600 ATP binding site [chemical binding]; other site 1302650001601 substrate binding site [chemical binding]; other site 1302650001602 activation loop (A-loop); other site 1302650001603 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1302650001604 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1302650001605 active site 1302650001606 zinc binding site [ion binding]; other site 1302650001607 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1302650001608 active site 1302650001609 ATP binding site [chemical binding]; other site 1302650001610 substrate binding site [chemical binding]; other site 1302650001611 activation loop (A-loop); other site 1302650001612 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 1302650001613 active site 1302650001614 zinc binding site [ion binding]; other site 1302650001615 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302650001616 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650001617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650001618 Walker A/P-loop; other site 1302650001619 ATP binding site [chemical binding]; other site 1302650001620 Q-loop/lid; other site 1302650001621 ABC transporter signature motif; other site 1302650001622 Walker B; other site 1302650001623 D-loop; other site 1302650001624 H-loop/switch region; other site 1302650001625 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1302650001626 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302650001627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650001628 non-specific DNA binding site [nucleotide binding]; other site 1302650001629 salt bridge; other site 1302650001630 sequence-specific DNA binding site [nucleotide binding]; other site 1302650001631 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1302650001632 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1302650001633 putative di-iron ligands [ion binding]; other site 1302650001634 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1302650001635 DNA-binding site [nucleotide binding]; DNA binding site 1302650001636 RNA-binding motif; other site 1302650001637 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1302650001638 Cupin domain; Region: Cupin_2; pfam07883 1302650001639 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302650001640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650001641 EamA-like transporter family; Region: EamA; pfam00892 1302650001642 EamA-like transporter family; Region: EamA; pfam00892 1302650001643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302650001644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650001645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1302650001646 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1302650001647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650001648 DNA-binding site [nucleotide binding]; DNA binding site 1302650001649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650001650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650001651 homodimer interface [polypeptide binding]; other site 1302650001652 catalytic residue [active] 1302650001653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001654 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650001655 putative substrate translocation pore; other site 1302650001656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1302650001657 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1302650001658 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1302650001659 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1302650001660 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1302650001661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650001662 DNA-binding site [nucleotide binding]; DNA binding site 1302650001663 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650001664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650001665 homodimer interface [polypeptide binding]; other site 1302650001666 catalytic residue [active] 1302650001667 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1302650001668 putative active site [active] 1302650001669 putative catalytic site [active] 1302650001670 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1302650001671 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1302650001672 Predicted transcriptional regulators [Transcription]; Region: COG1733 1302650001673 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1302650001674 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1302650001675 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650001676 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1302650001677 Predicted transcriptional regulators [Transcription]; Region: COG1733 1302650001678 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1302650001679 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1302650001680 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1302650001681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650001683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650001684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650001685 dimerization interface [polypeptide binding]; other site 1302650001686 putative DNA binding site [nucleotide binding]; other site 1302650001687 putative Zn2+ binding site [ion binding]; other site 1302650001688 arsenical pump membrane protein; Provisional; Region: PRK15445 1302650001689 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1302650001690 transmembrane helices; other site 1302650001691 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1302650001692 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1302650001693 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1302650001694 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1302650001695 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1302650001696 NodB motif; other site 1302650001697 active site 1302650001698 catalytic site [active] 1302650001699 Zn binding site [ion binding]; other site 1302650001700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650001701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650001702 dimerization interface [polypeptide binding]; other site 1302650001703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650001704 dimer interface [polypeptide binding]; other site 1302650001705 phosphorylation site [posttranslational modification] 1302650001706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650001707 ATP binding site [chemical binding]; other site 1302650001708 Mg2+ binding site [ion binding]; other site 1302650001709 G-X-G motif; other site 1302650001710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650001711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650001712 active site 1302650001713 phosphorylation site [posttranslational modification] 1302650001714 intermolecular recognition site; other site 1302650001715 dimerization interface [polypeptide binding]; other site 1302650001716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650001717 DNA binding site [nucleotide binding] 1302650001718 EamA-like transporter family; Region: EamA; pfam00892 1302650001719 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1302650001720 EamA-like transporter family; Region: EamA; pfam00892 1302650001721 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1302650001722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650001723 DNA-binding site [nucleotide binding]; DNA binding site 1302650001724 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650001725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650001726 homodimer interface [polypeptide binding]; other site 1302650001727 catalytic residue [active] 1302650001728 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1302650001729 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650001730 putative DNA binding site [nucleotide binding]; other site 1302650001731 putative Zn2+ binding site [ion binding]; other site 1302650001732 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1302650001733 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1302650001734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302650001735 Histidine kinase; Region: HisKA_3; pfam07730 1302650001736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650001737 ATP binding site [chemical binding]; other site 1302650001738 Mg2+ binding site [ion binding]; other site 1302650001739 G-X-G motif; other site 1302650001740 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650001741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650001742 active site 1302650001743 phosphorylation site [posttranslational modification] 1302650001744 intermolecular recognition site; other site 1302650001745 dimerization interface [polypeptide binding]; other site 1302650001746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650001747 DNA binding residues [nucleotide binding] 1302650001748 dimerization interface [polypeptide binding]; other site 1302650001749 MMPL family; Region: MMPL; pfam03176 1302650001750 MMPL family; Region: MMPL; pfam03176 1302650001751 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650001752 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1302650001753 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1302650001754 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1302650001755 DNA binding residues [nucleotide binding] 1302650001756 drug binding residues [chemical binding]; other site 1302650001757 dimer interface [polypeptide binding]; other site 1302650001758 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1302650001759 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1302650001760 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1302650001761 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1302650001762 dimer interface [polypeptide binding]; other site 1302650001763 FMN binding site [chemical binding]; other site 1302650001764 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1302650001765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650001766 Zn binding site [ion binding]; other site 1302650001767 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1302650001768 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650001769 Zn binding site [ion binding]; other site 1302650001770 Predicted membrane protein [Function unknown]; Region: COG2259 1302650001771 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302650001772 catalytic residues [active] 1302650001773 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1302650001774 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1302650001775 Predicted membrane protein [Function unknown]; Region: COG2323 1302650001776 Predicted membrane protein [Function unknown]; Region: COG2323 1302650001777 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1302650001778 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1302650001779 putative dimer interface [polypeptide binding]; other site 1302650001780 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1302650001781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650001782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650001783 DoxX-like family; Region: DoxX_2; pfam13564 1302650001784 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302650001785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650001786 Coenzyme A binding pocket [chemical binding]; other site 1302650001787 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1302650001788 nucleotide binding site/active site [active] 1302650001789 HIT family signature motif; other site 1302650001790 catalytic residue [active] 1302650001791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001792 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650001793 putative substrate translocation pore; other site 1302650001794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650001795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650001796 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1302650001797 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650001798 ABC transporter; Region: ABC_tran_2; pfam12848 1302650001799 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650001800 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1302650001801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1302650001802 DinB superfamily; Region: DinB_2; pfam12867 1302650001803 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650001804 MarR family; Region: MarR; pfam01047 1302650001805 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1302650001806 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1302650001807 dimer interface [polypeptide binding]; other site 1302650001808 FMN binding site [chemical binding]; other site 1302650001809 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650001810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650001811 putative DNA binding site [nucleotide binding]; other site 1302650001812 putative Zn2+ binding site [ion binding]; other site 1302650001813 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1302650001814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001815 putative substrate translocation pore; other site 1302650001816 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1302650001817 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1302650001818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650001819 DNA-binding site [nucleotide binding]; DNA binding site 1302650001820 FCD domain; Region: FCD; pfam07729 1302650001821 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1302650001822 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650001823 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650001824 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1302650001825 active site 1302650001826 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1302650001827 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1302650001828 homodimer interface [polypeptide binding]; other site 1302650001829 active site 1302650001830 TDP-binding site; other site 1302650001831 acceptor substrate-binding pocket; other site 1302650001832 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1302650001833 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1302650001834 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1302650001835 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1302650001836 dimer interface [polypeptide binding]; other site 1302650001837 active site 1302650001838 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1302650001839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650001840 Coenzyme A binding pocket [chemical binding]; other site 1302650001841 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1302650001842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302650001843 Zn2+ binding site [ion binding]; other site 1302650001844 Mg2+ binding site [ion binding]; other site 1302650001845 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1302650001846 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1302650001847 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1302650001848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001849 putative substrate translocation pore; other site 1302650001850 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1302650001851 active site 1302650001852 P-loop; other site 1302650001853 phosphorylation site [posttranslational modification] 1302650001854 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1302650001855 active site 1302650001856 methionine cluster; other site 1302650001857 phosphorylation site [posttranslational modification] 1302650001858 metal binding site [ion binding]; metal-binding site 1302650001859 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1302650001860 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1302650001861 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1302650001862 beta-galactosidase; Region: BGL; TIGR03356 1302650001863 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1302650001864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650001865 DNA-binding site [nucleotide binding]; DNA binding site 1302650001866 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1302650001867 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1302650001868 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302650001869 nucleotide binding site [chemical binding]; other site 1302650001870 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1302650001871 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1302650001872 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1302650001873 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1302650001874 dimanganese center [ion binding]; other site 1302650001875 potential protein location (hypothetical protein I653_02965 [Bacillus subtilis subsp. subtilis str. BAB-1]) that overlaps RNA (tRNA-A) 1302650001876 potential protein location (hypothetical protein I653_02965 [Bacillus subtilis subsp. subtilis str. BAB-1]) that overlaps RNA (tRNA-M) 1302650001877 potential protein location (hypothetical protein I653_02965 [Bacillus subtilis subsp. subtilis str. BAB-1]) that overlaps RNA (tRNA-P) 1302650001878 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1302650001879 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1302650001880 ATP binding site [chemical binding]; other site 1302650001881 dimerization interface [polypeptide binding]; other site 1302650001882 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1302650001883 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1302650001884 Glycoprotease family; Region: Peptidase_M22; pfam00814 1302650001885 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1302650001886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650001887 Coenzyme A binding pocket [chemical binding]; other site 1302650001888 UGMP family protein; Validated; Region: PRK09604 1302650001889 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1302650001890 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1302650001891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650001892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650001893 ABC transporter; Region: ABC_tran_2; pfam12848 1302650001894 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650001895 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1302650001896 trimer interface [polypeptide binding]; other site 1302650001897 dimer interface [polypeptide binding]; other site 1302650001898 putative active site [active] 1302650001899 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1302650001900 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1302650001901 CoA binding domain; Region: CoA_binding; pfam02629 1302650001902 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1302650001903 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 1302650001904 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1302650001905 CAAX protease self-immunity; Region: Abi; pfam02517 1302650001906 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1302650001907 oligomerisation interface [polypeptide binding]; other site 1302650001908 mobile loop; other site 1302650001909 roof hairpin; other site 1302650001910 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1302650001911 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1302650001912 ring oligomerisation interface [polypeptide binding]; other site 1302650001913 ATP/Mg binding site [chemical binding]; other site 1302650001914 stacking interactions; other site 1302650001915 hinge regions; other site 1302650001916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1302650001917 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1302650001918 NB-ARC domain; Region: NB-ARC; pfam00931 1302650001919 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650001920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650001921 TPR motif; other site 1302650001922 TPR repeat; Region: TPR_11; pfam13414 1302650001923 binding surface 1302650001924 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1302650001925 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1302650001926 inhibitor binding site; inhibition site 1302650001927 catalytic Zn binding site [ion binding]; other site 1302650001928 structural Zn binding site [ion binding]; other site 1302650001929 NADP binding site [chemical binding]; other site 1302650001930 tetramer interface [polypeptide binding]; other site 1302650001931 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1302650001932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001933 putative substrate translocation pore; other site 1302650001934 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1302650001935 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1302650001936 putative substrate binding site [chemical binding]; other site 1302650001937 putative ATP binding site [chemical binding]; other site 1302650001938 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1302650001939 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1302650001940 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 1302650001941 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1302650001942 Repair protein; Region: Repair_PSII; pfam04536 1302650001943 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1302650001944 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1302650001945 Double zinc ribbon; Region: DZR; pfam12773 1302650001946 Ion channel; Region: Ion_trans_2; pfam07885 1302650001947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001948 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1302650001949 putative substrate translocation pore; other site 1302650001950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650001951 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1302650001952 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1302650001953 putative NAD(P) binding site [chemical binding]; other site 1302650001954 catalytic Zn binding site [ion binding]; other site 1302650001955 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1302650001956 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1302650001957 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650001958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1302650001959 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1302650001960 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1302650001961 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1302650001962 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1302650001963 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1302650001964 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1302650001965 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1302650001966 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1302650001967 MoxR-like ATPases [General function prediction only]; Region: COG0714 1302650001968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650001969 Walker A motif; other site 1302650001970 ATP binding site [chemical binding]; other site 1302650001971 Walker B motif; other site 1302650001972 arginine finger; other site 1302650001973 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1302650001974 Protein of unknown function DUF58; Region: DUF58; pfam01882 1302650001975 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1302650001976 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1302650001977 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1302650001978 GMP synthase; Reviewed; Region: guaA; PRK00074 1302650001979 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1302650001980 AMP/PPi binding site [chemical binding]; other site 1302650001981 candidate oxyanion hole; other site 1302650001982 catalytic triad [active] 1302650001983 potential glutamine specificity residues [chemical binding]; other site 1302650001984 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1302650001985 ATP Binding subdomain [chemical binding]; other site 1302650001986 Ligand Binding sites [chemical binding]; other site 1302650001987 Dimerization subdomain; other site 1302650001988 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1302650001989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650001990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650001991 DNA binding residues [nucleotide binding] 1302650001992 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1302650001993 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1302650001994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1302650001995 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1302650001996 NETI protein; Region: NETI; pfam14044 1302650001997 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1302650001998 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1302650001999 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1302650002000 NAD binding site [chemical binding]; other site 1302650002001 ATP-grasp domain; Region: ATP-grasp; pfam02222 1302650002002 adenylosuccinate lyase; Provisional; Region: PRK07492 1302650002003 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1302650002004 tetramer interface [polypeptide binding]; other site 1302650002005 active site 1302650002006 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1302650002007 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1302650002008 ATP binding site [chemical binding]; other site 1302650002009 active site 1302650002010 substrate binding site [chemical binding]; other site 1302650002011 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1302650002012 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1302650002013 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1302650002014 putative active site [active] 1302650002015 catalytic triad [active] 1302650002016 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1302650002017 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1302650002018 dimerization interface [polypeptide binding]; other site 1302650002019 ATP binding site [chemical binding]; other site 1302650002020 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1302650002021 dimerization interface [polypeptide binding]; other site 1302650002022 ATP binding site [chemical binding]; other site 1302650002023 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1302650002024 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1302650002025 active site 1302650002026 tetramer interface [polypeptide binding]; other site 1302650002027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650002028 active site 1302650002029 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1302650002030 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1302650002031 dimerization interface [polypeptide binding]; other site 1302650002032 putative ATP binding site [chemical binding]; other site 1302650002033 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1302650002034 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1302650002035 active site 1302650002036 substrate binding site [chemical binding]; other site 1302650002037 cosubstrate binding site; other site 1302650002038 catalytic site [active] 1302650002039 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1302650002040 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1302650002041 purine monophosphate binding site [chemical binding]; other site 1302650002042 dimer interface [polypeptide binding]; other site 1302650002043 putative catalytic residues [active] 1302650002044 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1302650002045 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1302650002046 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1302650002047 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1302650002048 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1302650002049 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1302650002050 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1302650002051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650002052 putative DNA binding site [nucleotide binding]; other site 1302650002053 putative Zn2+ binding site [ion binding]; other site 1302650002054 AsnC family; Region: AsnC_trans_reg; pfam01037 1302650002055 putative transporter; Provisional; Region: PRK11021 1302650002056 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1302650002057 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1302650002058 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1302650002059 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1302650002060 active site 1302650002061 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1302650002062 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1302650002063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1302650002064 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1302650002065 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1302650002066 active site 1302650002067 FMN binding site [chemical binding]; other site 1302650002068 substrate binding site [chemical binding]; other site 1302650002069 3Fe-4S cluster binding site [ion binding]; other site 1302650002070 PcrB family; Region: PcrB; pfam01884 1302650002071 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1302650002072 substrate binding site [chemical binding]; other site 1302650002073 putative active site [active] 1302650002074 dimer interface [polypeptide binding]; other site 1302650002075 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1302650002076 Part of AAA domain; Region: AAA_19; pfam13245 1302650002077 Family description; Region: UvrD_C_2; pfam13538 1302650002078 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1302650002079 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1302650002080 nucleotide binding pocket [chemical binding]; other site 1302650002081 K-X-D-G motif; other site 1302650002082 catalytic site [active] 1302650002083 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1302650002084 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1302650002085 Helix-hairpin-helix motif; Region: HHH; pfam00633 1302650002086 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1302650002087 Dimer interface [polypeptide binding]; other site 1302650002088 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1302650002089 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1302650002090 putative dimer interface [polypeptide binding]; other site 1302650002091 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1302650002092 putative dimer interface [polypeptide binding]; other site 1302650002093 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1302650002094 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1302650002095 active site 1302650002096 ATP binding site [chemical binding]; other site 1302650002097 substrate binding site [chemical binding]; other site 1302650002098 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1302650002099 MgtC family; Region: MgtC; pfam02308 1302650002100 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1302650002101 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1302650002102 Na binding site [ion binding]; other site 1302650002103 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1302650002104 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1302650002105 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1302650002106 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1302650002107 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1302650002108 GatB domain; Region: GatB_Yqey; pfam02637 1302650002109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650002110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650002111 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1302650002112 Protein export membrane protein; Region: SecD_SecF; cl14618 1302650002113 Protein export membrane protein; Region: SecD_SecF; cl14618 1302650002114 putative lipid kinase; Reviewed; Region: PRK13337 1302650002115 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1302650002116 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1302650002117 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1302650002118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650002119 S-adenosylmethionine binding site [chemical binding]; other site 1302650002120 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1302650002121 Predicted ATPase [General function prediction only]; Region: COG5293 1302650002122 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 1302650002123 potential frameshift: common BLAST hit: gi|386757344|ref|YP_006230560.1| McrA protein 1302650002124 Protein of unknown function, DUF600; Region: DUF600; cl04640 1302650002125 Protein of unknown function, DUF600; Region: DUF600; cl04640 1302650002126 Protein of unknown function, DUF600; Region: DUF600; cl04640 1302650002127 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1302650002128 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1302650002129 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1302650002130 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1302650002131 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1302650002132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650002133 binding surface 1302650002134 TPR motif; other site 1302650002135 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650002136 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650002137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650002138 TPR motif; other site 1302650002139 binding surface 1302650002140 hypothetical protein; Provisional; Region: PRK12378 1302650002141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650002142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650002143 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1302650002144 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1302650002145 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1302650002146 NADP binding site [chemical binding]; other site 1302650002147 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1302650002148 CotJB protein; Region: CotJB; pfam12652 1302650002149 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1302650002150 dimanganese center [ion binding]; other site 1302650002151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650002152 Coenzyme A binding pocket [chemical binding]; other site 1302650002153 YesK-like protein; Region: YesK; pfam14150 1302650002154 Predicted integral membrane protein [Function unknown]; Region: COG5578 1302650002155 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1302650002156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650002157 dimerization interface [polypeptide binding]; other site 1302650002158 Histidine kinase; Region: His_kinase; pfam06580 1302650002159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650002160 ATP binding site [chemical binding]; other site 1302650002161 Mg2+ binding site [ion binding]; other site 1302650002162 G-X-G motif; other site 1302650002163 Response regulator receiver domain; Region: Response_reg; pfam00072 1302650002164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650002165 active site 1302650002166 phosphorylation site [posttranslational modification] 1302650002167 intermolecular recognition site; other site 1302650002168 dimerization interface [polypeptide binding]; other site 1302650002169 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302650002170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650002171 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1302650002172 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302650002173 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1302650002174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650002175 dimer interface [polypeptide binding]; other site 1302650002176 conserved gate region; other site 1302650002177 putative PBP binding loops; other site 1302650002178 ABC-ATPase subunit interface; other site 1302650002179 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302650002180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650002181 dimer interface [polypeptide binding]; other site 1302650002182 conserved gate region; other site 1302650002183 putative PBP binding loops; other site 1302650002184 ABC-ATPase subunit interface; other site 1302650002185 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1302650002186 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302650002187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650002188 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1302650002189 active site 1302650002190 catalytic triad [active] 1302650002191 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1302650002192 Predicted integral membrane protein [Function unknown]; Region: COG5578 1302650002193 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1302650002194 metal binding site [ion binding]; metal-binding site 1302650002195 active site 1302650002196 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1302650002197 metal binding site [ion binding]; metal-binding site 1302650002198 active site 1302650002199 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1302650002200 active site 1302650002201 catalytic triad [active] 1302650002202 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1302650002203 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1302650002204 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1302650002205 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1302650002206 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1302650002207 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302650002208 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1302650002209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650002210 dimer interface [polypeptide binding]; other site 1302650002211 putative PBP binding loops; other site 1302650002212 ABC-ATPase subunit interface; other site 1302650002213 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302650002214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650002215 dimer interface [polypeptide binding]; other site 1302650002216 conserved gate region; other site 1302650002217 putative PBP binding loops; other site 1302650002218 ABC-ATPase subunit interface; other site 1302650002219 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1302650002220 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1302650002221 NAD(P) binding site [chemical binding]; other site 1302650002222 LDH/MDH dimer interface [polypeptide binding]; other site 1302650002223 substrate binding site [chemical binding]; other site 1302650002224 Predicted membrane protein [Function unknown]; Region: COG2323 1302650002225 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1302650002226 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650002227 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1302650002228 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1302650002229 Uncharacterized small protein [Function unknown]; Region: COG5583 1302650002230 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1302650002231 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1302650002232 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1302650002233 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1302650002234 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1302650002235 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1302650002236 Cytochrome P450; Region: p450; pfam00067 1302650002237 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1302650002238 Flavodoxin; Region: Flavodoxin_1; pfam00258 1302650002239 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1302650002240 FAD binding pocket [chemical binding]; other site 1302650002241 FAD binding motif [chemical binding]; other site 1302650002242 catalytic residues [active] 1302650002243 NAD binding pocket [chemical binding]; other site 1302650002244 phosphate binding motif [ion binding]; other site 1302650002245 beta-alpha-beta structure motif; other site 1302650002246 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1302650002247 Sulfatase; Region: Sulfatase; pfam00884 1302650002248 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1302650002249 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1302650002250 substrate binding site; other site 1302650002251 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1302650002252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1302650002253 NAD(P) binding site [chemical binding]; other site 1302650002254 active site 1302650002255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1302650002256 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650002257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650002258 active site 1302650002259 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1302650002260 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1302650002261 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650002262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650002263 putative substrate translocation pore; other site 1302650002264 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1302650002265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650002266 active site 1302650002267 motif I; other site 1302650002268 motif II; other site 1302650002269 amino acid transporter; Region: 2A0306; TIGR00909 1302650002270 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1302650002271 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1302650002272 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1302650002273 NAD(P) binding site [chemical binding]; other site 1302650002274 catalytic residues [active] 1302650002275 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1302650002276 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650002277 dimer interface [polypeptide binding]; other site 1302650002278 putative CheW interface [polypeptide binding]; other site 1302650002279 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1302650002280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650002281 Walker A/P-loop; other site 1302650002282 ATP binding site [chemical binding]; other site 1302650002283 Q-loop/lid; other site 1302650002284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650002285 ABC transporter signature motif; other site 1302650002286 Walker B; other site 1302650002287 D-loop; other site 1302650002288 ABC transporter; Region: ABC_tran_2; pfam12848 1302650002289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650002290 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1302650002291 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1302650002292 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1302650002293 DNA binding residues [nucleotide binding] 1302650002294 putative dimer interface [polypeptide binding]; other site 1302650002295 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1302650002296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650002297 putative substrate translocation pore; other site 1302650002298 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1302650002299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650002300 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650002301 ABC transporter; Region: ABC_tran_2; pfam12848 1302650002302 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650002303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1302650002304 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1302650002305 ATP binding site [chemical binding]; other site 1302650002306 putative Mg++ binding site [ion binding]; other site 1302650002307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650002308 nucleotide binding region [chemical binding]; other site 1302650002309 ATP-binding site [chemical binding]; other site 1302650002310 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1302650002311 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302650002312 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1302650002313 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1302650002314 NAD(P) binding site [chemical binding]; other site 1302650002315 substrate binding site [chemical binding]; other site 1302650002316 dimer interface [polypeptide binding]; other site 1302650002317 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1302650002318 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1302650002319 Walker A/P-loop; other site 1302650002320 ATP binding site [chemical binding]; other site 1302650002321 Q-loop/lid; other site 1302650002322 ABC transporter signature motif; other site 1302650002323 Walker B; other site 1302650002324 D-loop; other site 1302650002325 H-loop/switch region; other site 1302650002326 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1302650002327 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650002328 ABC-ATPase subunit interface; other site 1302650002329 dimer interface [polypeptide binding]; other site 1302650002330 putative PBP binding regions; other site 1302650002331 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1302650002332 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650002333 ABC-ATPase subunit interface; other site 1302650002334 dimer interface [polypeptide binding]; other site 1302650002335 putative PBP binding regions; other site 1302650002336 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1302650002337 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1302650002338 siderophore binding site; other site 1302650002339 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1302650002340 Heat induced stress protein YflT; Region: YflT; pfam11181 1302650002341 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1302650002342 Amb_all domain; Region: Amb_all; smart00656 1302650002343 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1302650002344 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1302650002345 transmembrane helices; other site 1302650002346 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1302650002347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650002348 ATP binding site [chemical binding]; other site 1302650002349 Mg2+ binding site [ion binding]; other site 1302650002350 G-X-G motif; other site 1302650002351 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1302650002352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650002353 active site 1302650002354 phosphorylation site [posttranslational modification] 1302650002355 intermolecular recognition site; other site 1302650002356 dimerization interface [polypeptide binding]; other site 1302650002357 Transcriptional regulator; Region: CitT; pfam12431 1302650002358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1302650002359 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1302650002360 Citrate transporter; Region: CitMHS; pfam03600 1302650002361 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302650002362 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1302650002363 active site 1302650002364 dimer interface [polypeptide binding]; other site 1302650002365 acylphosphatase; Provisional; Region: PRK14420 1302650002366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1302650002367 MOSC domain; Region: MOSC; pfam03473 1302650002368 3-alpha domain; Region: 3-alpha; pfam03475 1302650002369 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1302650002370 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1302650002371 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1302650002372 active site 1302650002373 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1302650002374 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302650002375 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302650002376 active site turn [active] 1302650002377 phosphorylation site [posttranslational modification] 1302650002378 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1302650002379 Sulfatase; Region: Sulfatase; pfam00884 1302650002380 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1302650002381 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1302650002382 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1302650002383 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 1302650002384 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1302650002385 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1302650002386 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1302650002387 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1302650002388 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302650002389 active site turn [active] 1302650002390 phosphorylation site [posttranslational modification] 1302650002391 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302650002392 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1302650002393 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1302650002394 Ca binding site [ion binding]; other site 1302650002395 active site 1302650002396 catalytic site [active] 1302650002397 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1302650002398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650002399 DNA-binding site [nucleotide binding]; DNA binding site 1302650002400 UTRA domain; Region: UTRA; pfam07702 1302650002401 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1302650002402 dimer interface [polypeptide binding]; other site 1302650002403 FMN binding site [chemical binding]; other site 1302650002404 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1302650002405 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1302650002406 active site 1302650002407 metal binding site [ion binding]; metal-binding site 1302650002408 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1302650002409 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1302650002410 active site 1302650002411 metal binding site [ion binding]; metal-binding site 1302650002412 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1302650002413 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1302650002414 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1302650002415 proposed catalytic triad [active] 1302650002416 conserved cys residue [active] 1302650002417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650002418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650002419 putative substrate translocation pore; other site 1302650002420 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1302650002421 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1302650002422 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1302650002423 active site 1302650002424 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 1302650002425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650002426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650002427 putative substrate translocation pore; other site 1302650002428 calcium/proton exchanger (cax); Region: cax; TIGR00378 1302650002429 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1302650002430 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1302650002431 YfkD-like protein; Region: YfkD; pfam14167 1302650002432 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1302650002433 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1302650002434 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1302650002435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650002436 FeS/SAM binding site; other site 1302650002437 YfkB-like domain; Region: YfkB; pfam08756 1302650002438 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1302650002439 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1302650002440 NodB motif; other site 1302650002441 active site 1302650002442 catalytic site [active] 1302650002443 Cd binding site [ion binding]; other site 1302650002444 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1302650002445 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1302650002446 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1302650002447 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1302650002448 oligomer interface [polypeptide binding]; other site 1302650002449 metal binding site [ion binding]; metal-binding site 1302650002450 metal binding site [ion binding]; metal-binding site 1302650002451 putative Cl binding site [ion binding]; other site 1302650002452 aspartate ring; other site 1302650002453 basic sphincter; other site 1302650002454 hydrophobic gate; other site 1302650002455 periplasmic entrance; other site 1302650002456 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1302650002457 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1302650002458 minor groove reading motif; other site 1302650002459 helix-hairpin-helix signature motif; other site 1302650002460 substrate binding pocket [chemical binding]; other site 1302650002461 active site 1302650002462 TRAM domain; Region: TRAM; pfam01938 1302650002463 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1302650002464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650002465 S-adenosylmethionine binding site [chemical binding]; other site 1302650002466 YfzA-like protein; Region: YfzA; pfam14118 1302650002467 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1302650002468 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1302650002469 FMN binding site [chemical binding]; other site 1302650002470 active site 1302650002471 catalytic residues [active] 1302650002472 substrate binding site [chemical binding]; other site 1302650002473 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1302650002474 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1302650002475 tetramer interface [polypeptide binding]; other site 1302650002476 TPP-binding site [chemical binding]; other site 1302650002477 heterodimer interface [polypeptide binding]; other site 1302650002478 phosphorylation loop region [posttranslational modification] 1302650002479 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1302650002480 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1302650002481 alpha subunit interface [polypeptide binding]; other site 1302650002482 TPP binding site [chemical binding]; other site 1302650002483 heterodimer interface [polypeptide binding]; other site 1302650002484 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1302650002485 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1302650002486 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1302650002487 E3 interaction surface; other site 1302650002488 lipoyl attachment site [posttranslational modification]; other site 1302650002489 e3 binding domain; Region: E3_binding; pfam02817 1302650002490 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1302650002491 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1302650002492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650002493 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1302650002494 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1302650002495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650002496 Walker A motif; other site 1302650002497 ATP binding site [chemical binding]; other site 1302650002498 Walker B motif; other site 1302650002499 arginine finger; other site 1302650002500 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1302650002501 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 1302650002502 hypothetical protein; Provisional; Region: PRK02237 1302650002503 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1302650002504 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1302650002505 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1302650002506 NAD binding site [chemical binding]; other site 1302650002507 sugar binding site [chemical binding]; other site 1302650002508 divalent metal binding site [ion binding]; other site 1302650002509 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302650002510 dimer interface [polypeptide binding]; other site 1302650002511 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1302650002512 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1302650002513 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1302650002514 putative active site [active] 1302650002515 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1302650002516 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1302650002517 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302650002518 active site turn [active] 1302650002519 phosphorylation site [posttranslational modification] 1302650002520 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302650002521 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650002522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650002523 Walker A/P-loop; other site 1302650002524 ATP binding site [chemical binding]; other site 1302650002525 Q-loop/lid; other site 1302650002526 ABC transporter signature motif; other site 1302650002527 Walker B; other site 1302650002528 D-loop; other site 1302650002529 H-loop/switch region; other site 1302650002530 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302650002531 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650002532 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1302650002533 Walker A/P-loop; other site 1302650002534 ATP binding site [chemical binding]; other site 1302650002535 Q-loop/lid; other site 1302650002536 ABC transporter signature motif; other site 1302650002537 Walker B; other site 1302650002538 D-loop; other site 1302650002539 H-loop/switch region; other site 1302650002540 Predicted membrane protein [Function unknown]; Region: COG2259 1302650002541 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1302650002542 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1302650002543 putative metal binding site [ion binding]; other site 1302650002544 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1302650002545 active site 1302650002546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302650002547 Histidine kinase; Region: HisKA_3; pfam07730 1302650002548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650002549 ATP binding site [chemical binding]; other site 1302650002550 Mg2+ binding site [ion binding]; other site 1302650002551 G-X-G motif; other site 1302650002552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650002553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650002554 active site 1302650002555 phosphorylation site [posttranslational modification] 1302650002556 intermolecular recognition site; other site 1302650002557 dimerization interface [polypeptide binding]; other site 1302650002558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650002559 DNA binding residues [nucleotide binding] 1302650002560 dimerization interface [polypeptide binding]; other site 1302650002561 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302650002562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650002563 Walker A/P-loop; other site 1302650002564 ATP binding site [chemical binding]; other site 1302650002565 Q-loop/lid; other site 1302650002566 ABC transporter signature motif; other site 1302650002567 Walker B; other site 1302650002568 D-loop; other site 1302650002569 H-loop/switch region; other site 1302650002570 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1302650002571 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1302650002572 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1302650002573 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1302650002574 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1302650002575 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1302650002576 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302650002577 Predicted transcriptional regulators [Transcription]; Region: COG1695 1302650002578 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1302650002579 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1302650002580 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1302650002581 Lipase (class 2); Region: Lipase_2; pfam01674 1302650002582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650002583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650002584 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1302650002585 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1302650002586 NAD binding site [chemical binding]; other site 1302650002587 substrate binding site [chemical binding]; other site 1302650002588 putative active site [active] 1302650002589 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1302650002590 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1302650002591 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1302650002592 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1302650002593 Walker A/P-loop; other site 1302650002594 ATP binding site [chemical binding]; other site 1302650002595 Q-loop/lid; other site 1302650002596 ABC transporter signature motif; other site 1302650002597 Walker B; other site 1302650002598 D-loop; other site 1302650002599 H-loop/switch region; other site 1302650002600 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1302650002601 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1302650002602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650002603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650002604 H+ Antiporter protein; Region: 2A0121; TIGR00900 1302650002605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650002606 putative substrate translocation pore; other site 1302650002607 metal-dependent hydrolase; Provisional; Region: PRK13291 1302650002608 DinB superfamily; Region: DinB_2; pfam12867 1302650002609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650002610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650002611 putative substrate translocation pore; other site 1302650002612 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650002613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650002614 putative Zn2+ binding site [ion binding]; other site 1302650002615 putative DNA binding site [nucleotide binding]; other site 1302650002616 Predicted integral membrane protein [Function unknown]; Region: COG0392 1302650002617 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1302650002618 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1302650002619 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1302650002620 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1302650002621 siderophore binding site; other site 1302650002622 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1302650002623 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650002624 ABC-ATPase subunit interface; other site 1302650002625 dimer interface [polypeptide binding]; other site 1302650002626 putative PBP binding regions; other site 1302650002627 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1302650002628 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650002629 ABC-ATPase subunit interface; other site 1302650002630 dimer interface [polypeptide binding]; other site 1302650002631 putative PBP binding regions; other site 1302650002632 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1302650002633 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1302650002634 putative FMN binding site [chemical binding]; other site 1302650002635 YfhD-like protein; Region: YfhD; pfam14151 1302650002636 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1302650002637 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1302650002638 putative NAD(P) binding site [chemical binding]; other site 1302650002639 putative active site [active] 1302650002640 recombination regulator RecX; Provisional; Region: recX; PRK14135 1302650002641 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1302650002642 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1302650002643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650002644 putative substrate translocation pore; other site 1302650002645 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1302650002646 WVELL protein; Region: WVELL; pfam14043 1302650002647 Bacterial SH3 domain; Region: SH3_3; pfam08239 1302650002648 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1302650002649 Predicted integral membrane protein [Function unknown]; Region: COG5658 1302650002650 SdpI/YhfL protein family; Region: SdpI; pfam13630 1302650002651 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650002652 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1302650002653 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1302650002654 catalytic site [active] 1302650002655 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1302650002656 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1302650002657 Ligand binding site; other site 1302650002658 Putative Catalytic site; other site 1302650002659 DXD motif; other site 1302650002660 Predicted membrane protein [Function unknown]; Region: COG4485 1302650002661 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1302650002662 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1302650002663 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1302650002664 minor groove reading motif; other site 1302650002665 helix-hairpin-helix signature motif; other site 1302650002666 substrate binding pocket [chemical binding]; other site 1302650002667 active site 1302650002668 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1302650002669 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1302650002670 DNA binding and oxoG recognition site [nucleotide binding] 1302650002671 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1302650002672 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1302650002673 putative NAD(P) binding site [chemical binding]; other site 1302650002674 active site 1302650002675 YgaB-like protein; Region: YgaB; pfam14182 1302650002676 hypothetical protein; Provisional; Region: PRK13662 1302650002677 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302650002678 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650002679 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1302650002680 Walker A/P-loop; other site 1302650002681 ATP binding site [chemical binding]; other site 1302650002682 Q-loop/lid; other site 1302650002683 ABC transporter signature motif; other site 1302650002684 Walker B; other site 1302650002685 D-loop; other site 1302650002686 H-loop/switch region; other site 1302650002687 Predicted membrane protein [Function unknown]; Region: COG4129 1302650002688 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1302650002689 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1302650002690 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1302650002691 inhibitor-cofactor binding pocket; inhibition site 1302650002692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650002693 catalytic residue [active] 1302650002694 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1302650002695 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1302650002696 catalytic triad [active] 1302650002697 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1302650002698 metal binding site 2 [ion binding]; metal-binding site 1302650002699 putative DNA binding helix; other site 1302650002700 metal binding site 1 [ion binding]; metal-binding site 1302650002701 dimer interface [polypeptide binding]; other site 1302650002702 structural Zn2+ binding site [ion binding]; other site 1302650002703 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1302650002704 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1302650002705 SpoOM protein; Region: Spo0M; pfam07070 1302650002706 Coat F domain; Region: Coat_F; pfam07875 1302650002707 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1302650002708 active site pocket [active] 1302650002709 oxyanion hole [active] 1302650002710 catalytic triad [active] 1302650002711 active site nucleophile [active] 1302650002712 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1302650002713 ThiC-associated domain; Region: ThiC-associated; pfam13667 1302650002714 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1302650002715 Berberine and berberine like; Region: BBE; pfam08031 1302650002716 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1302650002717 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1302650002718 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1302650002719 tetramer interface [polypeptide binding]; other site 1302650002720 heme binding pocket [chemical binding]; other site 1302650002721 NADPH binding site [chemical binding]; other site 1302650002722 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1302650002723 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1302650002724 Walker A/P-loop; other site 1302650002725 ATP binding site [chemical binding]; other site 1302650002726 Q-loop/lid; other site 1302650002727 ABC transporter signature motif; other site 1302650002728 Walker B; other site 1302650002729 D-loop; other site 1302650002730 H-loop/switch region; other site 1302650002731 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1302650002732 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302650002733 substrate binding pocket [chemical binding]; other site 1302650002734 membrane-bound complex binding site; other site 1302650002735 hinge residues; other site 1302650002736 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1302650002737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650002738 dimer interface [polypeptide binding]; other site 1302650002739 conserved gate region; other site 1302650002740 putative PBP binding loops; other site 1302650002741 ABC-ATPase subunit interface; other site 1302650002742 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1302650002743 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1302650002744 active site 1302650002745 dimer interface [polypeptide binding]; other site 1302650002746 non-prolyl cis peptide bond; other site 1302650002747 insertion regions; other site 1302650002748 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1302650002749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302650002750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650002751 non-specific DNA binding site [nucleotide binding]; other site 1302650002752 salt bridge; other site 1302650002753 sequence-specific DNA binding site [nucleotide binding]; other site 1302650002754 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1302650002755 B3/4 domain; Region: B3_4; pfam03483 1302650002756 epoxyqueuosine reductase; Region: TIGR00276 1302650002757 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1302650002758 Putative amidase domain; Region: Amidase_6; pfam12671 1302650002759 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1302650002760 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1302650002761 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1302650002762 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1302650002763 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1302650002764 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1302650002765 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1302650002766 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1302650002767 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650002768 MarR family; Region: MarR; pfam01047 1302650002769 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1302650002770 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1302650002771 carboxyltransferase (CT) interaction site; other site 1302650002772 biotinylation site [posttranslational modification]; other site 1302650002773 HlyD family secretion protein; Region: HlyD_3; pfam13437 1302650002774 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1302650002775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650002776 putative substrate translocation pore; other site 1302650002777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650002778 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1302650002779 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1302650002780 Predicted transcriptional regulators [Transcription]; Region: COG1725 1302650002781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650002782 DNA-binding site [nucleotide binding]; DNA binding site 1302650002783 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1302650002784 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302650002785 Walker A/P-loop; other site 1302650002786 ATP binding site [chemical binding]; other site 1302650002787 Q-loop/lid; other site 1302650002788 ABC transporter signature motif; other site 1302650002789 Walker B; other site 1302650002790 D-loop; other site 1302650002791 H-loop/switch region; other site 1302650002792 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302650002793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650002794 Walker A/P-loop; other site 1302650002795 ATP binding site [chemical binding]; other site 1302650002796 Q-loop/lid; other site 1302650002797 ABC transporter signature motif; other site 1302650002798 Walker B; other site 1302650002799 D-loop; other site 1302650002800 H-loop/switch region; other site 1302650002801 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1302650002802 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1302650002803 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1302650002804 DNA-binding site [nucleotide binding]; DNA binding site 1302650002805 RNA-binding motif; other site 1302650002806 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1302650002807 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1302650002808 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1302650002809 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1302650002810 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1302650002811 metal binding site [ion binding]; metal-binding site 1302650002812 active site 1302650002813 I-site; other site 1302650002814 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1302650002815 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1302650002816 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1302650002817 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1302650002818 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1302650002819 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1302650002820 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1302650002821 generic binding surface II; other site 1302650002822 generic binding surface I; other site 1302650002823 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1302650002824 generic binding surface II; other site 1302650002825 generic binding surface I; other site 1302650002826 Staphylococcal nuclease homologues; Region: SNc; smart00318 1302650002827 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1302650002828 Catalytic site; other site 1302650002829 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1302650002830 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1302650002831 putative active site [active] 1302650002832 putative metal binding site [ion binding]; other site 1302650002833 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1302650002834 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1302650002835 active site 1302650002836 catalytic site [active] 1302650002837 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1302650002838 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650002839 RNA binding surface [nucleotide binding]; other site 1302650002840 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1302650002841 active site 1302650002842 FOG: CBS domain [General function prediction only]; Region: COG0517 1302650002843 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1302650002844 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1302650002845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650002846 motif II; other site 1302650002847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650002848 Coenzyme A binding pocket [chemical binding]; other site 1302650002849 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1302650002850 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1302650002851 putative active site [active] 1302650002852 catalytic triad [active] 1302650002853 putative dimer interface [polypeptide binding]; other site 1302650002854 aminotransferase; Validated; Region: PRK07678 1302650002855 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1302650002856 inhibitor-cofactor binding pocket; inhibition site 1302650002857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650002858 catalytic residue [active] 1302650002859 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1302650002860 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1302650002861 amphipathic channel; other site 1302650002862 Asn-Pro-Ala signature motifs; other site 1302650002863 glycerol kinase; Provisional; Region: glpK; PRK00047 1302650002864 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1302650002865 N- and C-terminal domain interface [polypeptide binding]; other site 1302650002866 active site 1302650002867 MgATP binding site [chemical binding]; other site 1302650002868 catalytic site [active] 1302650002869 metal binding site [ion binding]; metal-binding site 1302650002870 glycerol binding site [chemical binding]; other site 1302650002871 homotetramer interface [polypeptide binding]; other site 1302650002872 homodimer interface [polypeptide binding]; other site 1302650002873 FBP binding site [chemical binding]; other site 1302650002874 protein IIAGlc interface [polypeptide binding]; other site 1302650002875 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1302650002876 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1302650002877 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1302650002878 active site 1302650002879 substrate binding site [chemical binding]; other site 1302650002880 metal binding site [ion binding]; metal-binding site 1302650002881 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1302650002882 GAF domain; Region: GAF; pfam01590 1302650002883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302650002884 Histidine kinase; Region: HisKA_3; pfam07730 1302650002885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650002886 ATP binding site [chemical binding]; other site 1302650002887 Mg2+ binding site [ion binding]; other site 1302650002888 G-X-G motif; other site 1302650002889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650002890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650002891 active site 1302650002892 phosphorylation site [posttranslational modification] 1302650002893 intermolecular recognition site; other site 1302650002894 dimerization interface [polypeptide binding]; other site 1302650002895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650002896 DNA binding residues [nucleotide binding] 1302650002897 dimerization interface [polypeptide binding]; other site 1302650002898 Predicted flavoprotein [General function prediction only]; Region: COG0431 1302650002899 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1302650002900 YhdB-like protein; Region: YhdB; pfam14148 1302650002901 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1302650002902 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650002903 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650002904 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650002905 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650002906 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650002907 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1302650002908 NlpC/P60 family; Region: NLPC_P60; pfam00877 1302650002909 Transcriptional regulator; Region: Rrf2; cl17282 1302650002910 Rrf2 family protein; Region: rrf2_super; TIGR00738 1302650002911 Transposase domain (DUF772); Region: DUF772; pfam05598 1302650002912 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1302650002913 Conserved TM helix; Region: TM_helix; pfam05552 1302650002914 Conserved TM helix; Region: TM_helix; pfam05552 1302650002915 Conserved TM helix; Region: TM_helix; pfam05552 1302650002916 Conserved TM helix; Region: TM_helix; pfam05552 1302650002917 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1302650002918 SpoVR like protein; Region: SpoVR; pfam04293 1302650002919 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1302650002920 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1302650002921 dimer interface [polypeptide binding]; other site 1302650002922 active site 1302650002923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650002924 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650002925 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650002926 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1302650002927 NlpC/P60 family; Region: NLPC_P60; pfam00877 1302650002928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650002929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650002930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302650002931 dimerization interface [polypeptide binding]; other site 1302650002932 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1302650002933 dimer interface [polypeptide binding]; other site 1302650002934 Citrate synthase; Region: Citrate_synt; pfam00285 1302650002935 active site 1302650002936 citrylCoA binding site [chemical binding]; other site 1302650002937 oxalacetate/citrate binding site [chemical binding]; other site 1302650002938 coenzyme A binding site [chemical binding]; other site 1302650002939 catalytic triad [active] 1302650002940 short chain dehydrogenase; Provisional; Region: PRK06701 1302650002941 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1302650002942 NAD binding site [chemical binding]; other site 1302650002943 metal binding site [ion binding]; metal-binding site 1302650002944 active site 1302650002945 amino acid transporter; Region: 2A0306; TIGR00909 1302650002946 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1302650002947 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1302650002948 Na2 binding site [ion binding]; other site 1302650002949 putative substrate binding site 1 [chemical binding]; other site 1302650002950 Na binding site 1 [ion binding]; other site 1302650002951 putative substrate binding site 2 [chemical binding]; other site 1302650002952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650002953 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1302650002954 homodimer interface [polypeptide binding]; other site 1302650002955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650002956 catalytic residue [active] 1302650002957 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1302650002958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650002959 DNA-binding site [nucleotide binding]; DNA binding site 1302650002960 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1302650002961 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302650002962 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1302650002963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650002964 Coenzyme A binding pocket [chemical binding]; other site 1302650002965 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1302650002966 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1302650002967 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1302650002968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650002969 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650002970 DNA binding residues [nucleotide binding] 1302650002971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302650002972 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302650002973 active site 1302650002974 catalytic tetrad [active] 1302650002975 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1302650002976 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1302650002977 putative acyl-acceptor binding pocket; other site 1302650002978 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1302650002979 Domain of unknown function DUF21; Region: DUF21; pfam01595 1302650002980 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1302650002981 Transporter associated domain; Region: CorC_HlyC; smart01091 1302650002982 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1302650002983 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1302650002984 DNA binding residues [nucleotide binding] 1302650002985 putative dimer interface [polypeptide binding]; other site 1302650002986 aspartate aminotransferase; Provisional; Region: PRK06836 1302650002987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650002988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650002989 homodimer interface [polypeptide binding]; other site 1302650002990 catalytic residue [active] 1302650002991 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1302650002992 Domain of unknown function DUF21; Region: DUF21; pfam01595 1302650002993 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1302650002994 Transporter associated domain; Region: CorC_HlyC; smart01091 1302650002995 camphor resistance protein CrcB; Provisional; Region: PRK14213 1302650002996 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1302650002997 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1302650002998 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1302650002999 active site 1302650003000 catalytic site [active] 1302650003001 metal binding site [ion binding]; metal-binding site 1302650003002 dimer interface [polypeptide binding]; other site 1302650003003 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1302650003004 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1302650003005 NAD-dependent deacetylase; Provisional; Region: PRK00481 1302650003006 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1302650003007 NAD+ binding site [chemical binding]; other site 1302650003008 substrate binding site [chemical binding]; other site 1302650003009 Zn binding site [ion binding]; other site 1302650003010 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1302650003011 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1302650003012 NodB motif; other site 1302650003013 active site 1302650003014 catalytic site [active] 1302650003015 Zn binding site [ion binding]; other site 1302650003016 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1302650003017 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1302650003018 homodimer interface [polypeptide binding]; other site 1302650003019 substrate-cofactor binding pocket; other site 1302650003020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650003021 catalytic residue [active] 1302650003022 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1302650003023 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1302650003024 Ligand Binding Site [chemical binding]; other site 1302650003025 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650003026 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1302650003027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650003028 Walker A/P-loop; other site 1302650003029 ATP binding site [chemical binding]; other site 1302650003030 Q-loop/lid; other site 1302650003031 ABC transporter signature motif; other site 1302650003032 Walker B; other site 1302650003033 D-loop; other site 1302650003034 H-loop/switch region; other site 1302650003035 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302650003036 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650003037 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1302650003038 Walker A/P-loop; other site 1302650003039 ATP binding site [chemical binding]; other site 1302650003040 Q-loop/lid; other site 1302650003041 ABC transporter signature motif; other site 1302650003042 Walker B; other site 1302650003043 D-loop; other site 1302650003044 H-loop/switch region; other site 1302650003045 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1302650003046 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1302650003047 NAD binding site [chemical binding]; other site 1302650003048 substrate binding site [chemical binding]; other site 1302650003049 putative active site [active] 1302650003050 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1302650003051 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1302650003052 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1302650003053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1302650003054 hypothetical protein; Provisional; Region: PRK13676 1302650003055 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1302650003056 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1302650003057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650003058 active site 1302650003059 motif I; other site 1302650003060 motif II; other site 1302650003061 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1302650003062 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1302650003063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650003064 FeS/SAM binding site; other site 1302650003065 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1302650003066 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1302650003067 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1302650003068 TrkA-C domain; Region: TrkA_C; pfam02080 1302650003069 enoyl-CoA hydratase; Provisional; Region: PRK07659 1302650003070 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1302650003071 substrate binding site [chemical binding]; other site 1302650003072 oxyanion hole (OAH) forming residues; other site 1302650003073 trimer interface [polypeptide binding]; other site 1302650003074 YhzD-like protein; Region: YhzD; pfam14120 1302650003075 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1302650003076 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1302650003077 Walker A/P-loop; other site 1302650003078 ATP binding site [chemical binding]; other site 1302650003079 Q-loop/lid; other site 1302650003080 ABC transporter signature motif; other site 1302650003081 Walker B; other site 1302650003082 D-loop; other site 1302650003083 H-loop/switch region; other site 1302650003084 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1302650003085 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1302650003086 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1302650003087 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1302650003088 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1302650003089 active site 1302650003090 metal binding site [ion binding]; metal-binding site 1302650003091 DNA binding site [nucleotide binding] 1302650003092 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1302650003093 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1302650003094 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1302650003095 generic binding surface II; other site 1302650003096 generic binding surface I; other site 1302650003097 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302650003098 Zn2+ binding site [ion binding]; other site 1302650003099 Mg2+ binding site [ion binding]; other site 1302650003100 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1302650003101 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1302650003102 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1302650003103 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1302650003104 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1302650003105 transcriptional regulator Hpr; Provisional; Region: PRK13777 1302650003106 MarR family; Region: MarR; pfam01047 1302650003107 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1302650003108 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1302650003109 homodimer interface [polypeptide binding]; other site 1302650003110 substrate-cofactor binding pocket; other site 1302650003111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650003112 catalytic residue [active] 1302650003113 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1302650003114 HIT family signature motif; other site 1302650003115 catalytic residue [active] 1302650003116 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1302650003117 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302650003118 Walker A/P-loop; other site 1302650003119 ATP binding site [chemical binding]; other site 1302650003120 Q-loop/lid; other site 1302650003121 ABC transporter signature motif; other site 1302650003122 Walker B; other site 1302650003123 D-loop; other site 1302650003124 H-loop/switch region; other site 1302650003125 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1302650003126 EcsC protein family; Region: EcsC; pfam12787 1302650003127 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1302650003128 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1302650003129 metal binding site [ion binding]; metal-binding site 1302650003130 dimer interface [polypeptide binding]; other site 1302650003131 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1302650003132 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1302650003133 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1302650003134 Transglycosylase; Region: Transgly; pfam00912 1302650003135 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302650003136 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1302650003137 substrate binding site [chemical binding]; other site 1302650003138 active site 1302650003139 ferrochelatase; Provisional; Region: PRK12435 1302650003140 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1302650003141 C-terminal domain interface [polypeptide binding]; other site 1302650003142 active site 1302650003143 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1302650003144 active site 1302650003145 N-terminal domain interface [polypeptide binding]; other site 1302650003146 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1302650003147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1302650003148 SEA domain; Region: SEA; cl02507 1302650003149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650003150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650003151 Predicted membrane protein [Function unknown]; Region: COG1511 1302650003152 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1302650003153 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1302650003154 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1302650003155 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1302650003156 dimer interface [polypeptide binding]; other site 1302650003157 active site 1302650003158 CoA binding pocket [chemical binding]; other site 1302650003159 Predicted membrane protein [Function unknown]; Region: COG4377 1302650003160 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1302650003161 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1302650003162 putative oligomer interface [polypeptide binding]; other site 1302650003163 putative active site [active] 1302650003164 metal binding site [ion binding]; metal-binding site 1302650003165 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1302650003166 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1302650003167 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1302650003168 YhfH-like protein; Region: YhfH; pfam14149 1302650003169 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1302650003170 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1302650003171 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1302650003172 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1302650003173 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1302650003174 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1302650003175 NAD(P) binding site [chemical binding]; other site 1302650003176 putative active site [active] 1302650003177 potential frameshift: common BLAST hit: gi|449093727|ref|YP_007426218.1| acyl-CoA synthetase 1302650003178 potential frameshift: common BLAST hit: gi|402775251|ref|YP_006629195.1| protein YhfM 1302650003179 Peptidase family M48; Region: Peptidase_M48; pfam01435 1302650003180 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1302650003181 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1302650003182 active site 1302650003183 catalytic residues [active] 1302650003184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650003185 Coenzyme A binding pocket [chemical binding]; other site 1302650003186 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1302650003187 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1302650003188 putative NADP binding site [chemical binding]; other site 1302650003189 putative dimer interface [polypeptide binding]; other site 1302650003190 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1302650003191 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1302650003192 siderophore binding site; other site 1302650003193 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1302650003194 catalytic core [active] 1302650003195 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1302650003196 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1302650003197 dimer interface [polypeptide binding]; other site 1302650003198 active site 1302650003199 acyl-CoA synthetase; Validated; Region: PRK07638 1302650003200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1302650003201 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1302650003202 acyl-activating enzyme (AAE) consensus motif; other site 1302650003203 acyl-activating enzyme (AAE) consensus motif; other site 1302650003204 AMP binding site [chemical binding]; other site 1302650003205 active site 1302650003206 CoA binding site [chemical binding]; other site 1302650003207 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1302650003208 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1302650003209 heme-binding site [chemical binding]; other site 1302650003210 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1302650003211 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650003212 dimer interface [polypeptide binding]; other site 1302650003213 putative CheW interface [polypeptide binding]; other site 1302650003214 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1302650003215 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1302650003216 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1302650003217 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1302650003218 [2Fe-2S] cluster binding site [ion binding]; other site 1302650003219 short chain dehydrogenase; Provisional; Region: PRK06701 1302650003220 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1302650003221 NAD binding site [chemical binding]; other site 1302650003222 metal binding site [ion binding]; metal-binding site 1302650003223 active site 1302650003224 IDEAL domain; Region: IDEAL; pfam08858 1302650003225 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1302650003226 oxidoreductase; Provisional; Region: PRK07985 1302650003227 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1302650003228 NAD binding site [chemical binding]; other site 1302650003229 metal binding site [ion binding]; metal-binding site 1302650003230 active site 1302650003231 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1302650003232 Na binding site [ion binding]; other site 1302650003233 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1302650003234 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1302650003235 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1302650003236 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1302650003237 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1302650003238 Catalytic site [active] 1302650003239 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1302650003240 hypothetical protein; Provisional; Region: PRK08244 1302650003241 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1302650003242 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650003243 MarR family; Region: MarR; pfam01047 1302650003244 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1302650003245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650003246 putative substrate translocation pore; other site 1302650003247 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1302650003248 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1302650003249 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1302650003250 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1302650003251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650003252 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1302650003253 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1302650003254 inhibitor-cofactor binding pocket; inhibition site 1302650003255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650003256 catalytic residue [active] 1302650003257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650003258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650003259 DNA binding site [nucleotide binding] 1302650003260 domain linker motif; other site 1302650003261 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1302650003262 putative dimerization interface [polypeptide binding]; other site 1302650003263 putative ligand binding site [chemical binding]; other site 1302650003264 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1302650003265 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1302650003266 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1302650003267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650003268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650003269 putative substrate translocation pore; other site 1302650003270 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1302650003271 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1302650003272 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1302650003273 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1302650003274 dimerization interface [polypeptide binding]; other site 1302650003275 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1302650003276 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1302650003277 dinuclear metal binding motif [ion binding]; other site 1302650003278 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1302650003279 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1302650003280 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1302650003281 Part of AAA domain; Region: AAA_19; pfam13245 1302650003282 Family description; Region: UvrD_C_2; pfam13538 1302650003283 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1302650003284 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1302650003285 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1302650003286 active site 1302650003287 metal binding site [ion binding]; metal-binding site 1302650003288 DNA binding site [nucleotide binding] 1302650003289 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1302650003290 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1302650003291 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1302650003292 Walker A/P-loop; other site 1302650003293 ATP binding site [chemical binding]; other site 1302650003294 Q-loop/lid; other site 1302650003295 ABC transporter signature motif; other site 1302650003296 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1302650003297 ABC transporter signature motif; other site 1302650003298 Walker B; other site 1302650003299 D-loop; other site 1302650003300 H-loop/switch region; other site 1302650003301 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1302650003302 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1302650003303 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1302650003304 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1302650003305 Spore germination protein GerPC; Region: GerPC; pfam10737 1302650003306 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1302650003307 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1302650003308 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1302650003309 CotH protein; Region: CotH; pfam08757 1302650003310 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1302650003311 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1302650003312 hypothetical protein; Provisional; Region: PRK13673 1302650003313 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1302650003314 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1302650003315 active site 1302650003316 catalytic triad [active] 1302650003317 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1302650003318 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1302650003319 active site 1302650003320 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1302650003321 dimer interface [polypeptide binding]; other site 1302650003322 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1302650003323 Ligand Binding Site [chemical binding]; other site 1302650003324 Molecular Tunnel; other site 1302650003325 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1302650003326 substrate binding pocket [chemical binding]; other site 1302650003327 aspartate-rich region 2; other site 1302650003328 substrate-Mg2+ binding site; other site 1302650003329 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1302650003330 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1302650003331 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1302650003332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650003333 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302650003334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650003335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650003336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650003337 DNA binding site [nucleotide binding] 1302650003338 domain linker motif; other site 1302650003339 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1302650003340 dimerization interface [polypeptide binding]; other site 1302650003341 ligand binding site [chemical binding]; other site 1302650003342 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1302650003343 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1302650003344 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1302650003345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1302650003346 Lysine efflux permease [General function prediction only]; Region: COG1279 1302650003347 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1302650003348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650003349 DNA-binding site [nucleotide binding]; DNA binding site 1302650003350 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650003351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650003352 homodimer interface [polypeptide binding]; other site 1302650003353 catalytic residue [active] 1302650003354 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1302650003355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1302650003356 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1302650003357 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650003358 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1302650003359 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1302650003360 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1302650003361 ligand-binding site [chemical binding]; other site 1302650003362 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1302650003363 ATP-sulfurylase; Region: ATPS; cd00517 1302650003364 active site 1302650003365 HXXH motif; other site 1302650003366 flexible loop; other site 1302650003367 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1302650003368 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1302650003369 Active Sites [active] 1302650003370 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1302650003371 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1302650003372 (2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809 1302650003373 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1302650003374 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650003375 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1302650003376 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1302650003377 active site pocket [active] 1302650003378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650003379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650003380 putative substrate translocation pore; other site 1302650003381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1302650003382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650003383 Coenzyme A binding pocket [chemical binding]; other site 1302650003384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1302650003385 Coenzyme A binding pocket [chemical binding]; other site 1302650003386 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1302650003387 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1302650003388 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1302650003389 FAD binding site [chemical binding]; other site 1302650003390 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 1302650003391 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 1302650003392 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1302650003393 S1 domain; Region: S1_2; pfam13509 1302650003394 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1302650003395 RNA binding site [nucleotide binding]; other site 1302650003396 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1302650003397 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1302650003398 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1302650003399 Predicted transcriptional regulators [Transcription]; Region: COG1695 1302650003400 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1302650003401 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1302650003402 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1302650003403 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1302650003404 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1302650003405 active site 1302650003406 Zn binding site [ion binding]; other site 1302650003407 EDD domain protein, DegV family; Region: DegV; TIGR00762 1302650003408 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1302650003409 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1302650003410 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650003411 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650003412 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1302650003413 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1302650003414 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1302650003415 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1302650003416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650003417 motif II; other site 1302650003418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650003419 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1302650003420 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1302650003421 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1302650003422 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1302650003423 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1302650003424 FAD binding domain; Region: FAD_binding_4; pfam01565 1302650003425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650003426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650003427 putative substrate translocation pore; other site 1302650003428 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1302650003429 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1302650003430 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1302650003431 heterotetramer interface [polypeptide binding]; other site 1302650003432 active site pocket [active] 1302650003433 cleavage site 1302650003434 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1302650003435 nucleotide binding site [chemical binding]; other site 1302650003436 N-acetyl-L-glutamate binding site [chemical binding]; other site 1302650003437 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1302650003438 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1302650003439 inhibitor-cofactor binding pocket; inhibition site 1302650003440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650003441 catalytic residue [active] 1302650003442 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1302650003443 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1302650003444 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1302650003445 catalytic site [active] 1302650003446 subunit interface [polypeptide binding]; other site 1302650003447 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1302650003448 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1302650003449 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1302650003450 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1302650003451 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1302650003452 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1302650003453 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1302650003454 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1302650003455 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1302650003456 YjzC-like protein; Region: YjzC; pfam14168 1302650003457 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1302650003458 UDP-apiose/xylose synthase; Region: PLN02427 1302650003459 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1302650003460 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1302650003461 putative ligand binding site [chemical binding]; other site 1302650003462 ComZ; Region: ComZ; pfam10815 1302650003463 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1302650003464 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1302650003465 dimer interface [polypeptide binding]; other site 1302650003466 active site 1302650003467 CoA binding pocket [chemical binding]; other site 1302650003468 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1302650003469 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1302650003470 dimer interface [polypeptide binding]; other site 1302650003471 active site 1302650003472 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1302650003473 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1302650003474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1302650003475 Walker A/P-loop; other site 1302650003476 ATP binding site [chemical binding]; other site 1302650003477 Q-loop/lid; other site 1302650003478 ABC transporter signature motif; other site 1302650003479 Walker B; other site 1302650003480 D-loop; other site 1302650003481 H-loop/switch region; other site 1302650003482 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1302650003483 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1302650003484 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1302650003485 Walker A/P-loop; other site 1302650003486 ATP binding site [chemical binding]; other site 1302650003487 Q-loop/lid; other site 1302650003488 ABC transporter signature motif; other site 1302650003489 Walker B; other site 1302650003490 D-loop; other site 1302650003491 H-loop/switch region; other site 1302650003492 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1302650003493 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1302650003494 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1302650003495 peptide binding site [polypeptide binding]; other site 1302650003496 potential frameshift: common BLAST hit: gi|350265420|ref|YP_004876727.1| oligopeptide transport system permease AppB 1302650003497 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1302650003498 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1302650003499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650003500 dimer interface [polypeptide binding]; other site 1302650003501 conserved gate region; other site 1302650003502 putative PBP binding loops; other site 1302650003503 ABC-ATPase subunit interface; other site 1302650003504 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1302650003505 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1302650003506 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1302650003507 active site 1302650003508 HIGH motif; other site 1302650003509 dimer interface [polypeptide binding]; other site 1302650003510 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1302650003511 KMSKS motif; other site 1302650003512 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1302650003513 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1302650003514 peptide binding site [polypeptide binding]; other site 1302650003515 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1302650003516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650003517 dimer interface [polypeptide binding]; other site 1302650003518 conserved gate region; other site 1302650003519 putative PBP binding loops; other site 1302650003520 ABC-ATPase subunit interface; other site 1302650003521 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1302650003522 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1302650003523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650003524 dimer interface [polypeptide binding]; other site 1302650003525 conserved gate region; other site 1302650003526 putative PBP binding loops; other site 1302650003527 ABC-ATPase subunit interface; other site 1302650003528 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1302650003529 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1302650003530 Walker A/P-loop; other site 1302650003531 ATP binding site [chemical binding]; other site 1302650003532 Q-loop/lid; other site 1302650003533 ABC transporter signature motif; other site 1302650003534 Walker B; other site 1302650003535 D-loop; other site 1302650003536 H-loop/switch region; other site 1302650003537 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1302650003538 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1302650003539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1302650003540 Walker A/P-loop; other site 1302650003541 ATP binding site [chemical binding]; other site 1302650003542 Q-loop/lid; other site 1302650003543 ABC transporter signature motif; other site 1302650003544 Walker B; other site 1302650003545 D-loop; other site 1302650003546 H-loop/switch region; other site 1302650003547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1302650003548 H+ Antiporter protein; Region: 2A0121; TIGR00900 1302650003549 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1302650003550 ArsC family; Region: ArsC; pfam03960 1302650003551 putative catalytic residues [active] 1302650003552 thiol/disulfide switch; other site 1302650003553 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1302650003554 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1302650003555 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 1302650003556 oligoendopeptidase F; Region: pepF; TIGR00181 1302650003557 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1302650003558 active site 1302650003559 Zn binding site [ion binding]; other site 1302650003560 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1302650003561 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1302650003562 catalytic residues [active] 1302650003563 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1302650003564 apolar tunnel; other site 1302650003565 heme binding site [chemical binding]; other site 1302650003566 dimerization interface [polypeptide binding]; other site 1302650003567 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1302650003568 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1302650003569 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1302650003570 catalytic residue [active] 1302650003571 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1302650003572 putative active site [active] 1302650003573 putative metal binding residues [ion binding]; other site 1302650003574 signature motif; other site 1302650003575 putative triphosphate binding site [ion binding]; other site 1302650003576 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1302650003577 synthetase active site [active] 1302650003578 NTP binding site [chemical binding]; other site 1302650003579 metal binding site [ion binding]; metal-binding site 1302650003580 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1302650003581 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1302650003582 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1302650003583 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1302650003584 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1302650003585 active site 1302650003586 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1302650003587 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1302650003588 active site 1302650003589 metal binding site [ion binding]; metal-binding site 1302650003590 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1302650003591 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1302650003592 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1302650003593 TrkA-N domain; Region: TrkA_N; pfam02254 1302650003594 TrkA-C domain; Region: TrkA_C; pfam02080 1302650003595 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1302650003596 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1302650003597 thiamine phosphate binding site [chemical binding]; other site 1302650003598 active site 1302650003599 pyrophosphate binding site [ion binding]; other site 1302650003600 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1302650003601 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1302650003602 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1302650003603 thiS-thiF/thiG interaction site; other site 1302650003604 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1302650003605 ThiS interaction site; other site 1302650003606 putative active site [active] 1302650003607 tetramer interface [polypeptide binding]; other site 1302650003608 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1302650003609 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1302650003610 ATP binding site [chemical binding]; other site 1302650003611 substrate interface [chemical binding]; other site 1302650003612 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1302650003613 dimer interface [polypeptide binding]; other site 1302650003614 substrate binding site [chemical binding]; other site 1302650003615 ATP binding site [chemical binding]; other site 1302650003616 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1302650003617 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1302650003618 NAD binding site [chemical binding]; other site 1302650003619 homotetramer interface [polypeptide binding]; other site 1302650003620 homodimer interface [polypeptide binding]; other site 1302650003621 substrate binding site [chemical binding]; other site 1302650003622 active site 1302650003623 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1302650003624 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1302650003625 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1302650003626 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1302650003627 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1302650003628 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1302650003629 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1302650003630 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1302650003631 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1302650003632 Part of AAA domain; Region: AAA_19; pfam13245 1302650003633 Family description; Region: UvrD_C_2; pfam13538 1302650003634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650003635 Coenzyme A binding pocket [chemical binding]; other site 1302650003636 hypothetical protein; Provisional; Region: PRK13679 1302650003637 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1302650003638 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1302650003639 Putative esterase; Region: Esterase; pfam00756 1302650003640 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1302650003641 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1302650003642 homodimer interface [polypeptide binding]; other site 1302650003643 substrate-cofactor binding pocket; other site 1302650003644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650003645 catalytic residue [active] 1302650003646 cystathionine beta-lyase; Provisional; Region: PRK08064 1302650003647 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1302650003648 homodimer interface [polypeptide binding]; other site 1302650003649 substrate-cofactor binding pocket; other site 1302650003650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650003651 catalytic residue [active] 1302650003652 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1302650003653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1302650003654 Predicted integral membrane protein [Function unknown]; Region: COG5505 1302650003655 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1302650003656 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1302650003657 HTH domain; Region: HTH_11; pfam08279 1302650003658 Mga helix-turn-helix domain; Region: Mga; pfam05043 1302650003659 PRD domain; Region: PRD; pfam00874 1302650003660 PRD domain; Region: PRD; pfam00874 1302650003661 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1302650003662 active site 1302650003663 P-loop; other site 1302650003664 phosphorylation site [posttranslational modification] 1302650003665 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1302650003666 active site 1302650003667 phosphorylation site [posttranslational modification] 1302650003668 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1302650003669 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1302650003670 active site 1302650003671 P-loop; other site 1302650003672 phosphorylation site [posttranslational modification] 1302650003673 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1302650003674 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1302650003675 active site 1302650003676 phosphorylation site [posttranslational modification] 1302650003677 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1302650003678 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1302650003679 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1302650003680 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1302650003681 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302650003682 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1302650003683 putative deacylase active site [active] 1302650003684 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1302650003685 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1302650003686 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 1302650003687 UbiA prenyltransferase family; Region: UbiA; pfam01040 1302650003688 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1302650003689 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1302650003690 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1302650003691 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 1302650003692 NodB motif; other site 1302650003693 active site 1302650003694 catalytic site [active] 1302650003695 Zn binding site [ion binding]; other site 1302650003696 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1302650003697 Putative motility protein; Region: YjfB_motility; pfam14070 1302650003698 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1302650003699 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1302650003700 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1302650003701 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1302650003702 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1302650003703 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1302650003704 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1302650003705 4Fe-4S binding domain; Region: Fer4; pfam00037 1302650003706 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1302650003707 [4Fe-4S] binding site [ion binding]; other site 1302650003708 molybdopterin cofactor binding site; other site 1302650003709 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1302650003710 molybdopterin cofactor binding site; other site 1302650003711 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1302650003712 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1302650003713 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1302650003714 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1302650003715 nudix motif; other site 1302650003716 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1302650003717 Cytochrome P450; Region: p450; cl12078 1302650003718 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1302650003719 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1302650003720 active site 1302650003721 TDP-binding site; other site 1302650003722 acceptor substrate-binding pocket; other site 1302650003723 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1302650003724 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1302650003725 active site 1302650003726 TIGR00245 family protein; Region: TIGR00245 1302650003727 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1302650003728 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1302650003729 Walker A/P-loop; other site 1302650003730 ATP binding site [chemical binding]; other site 1302650003731 Q-loop/lid; other site 1302650003732 ABC transporter signature motif; other site 1302650003733 Walker B; other site 1302650003734 D-loop; other site 1302650003735 H-loop/switch region; other site 1302650003736 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1302650003737 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1302650003738 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1302650003739 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1302650003740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650003741 Glucuronate isomerase; Region: UxaC; pfam02614 1302650003742 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1302650003743 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1302650003744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650003745 putative substrate translocation pore; other site 1302650003746 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 1302650003747 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1302650003748 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1302650003749 putative NAD(P) binding site [chemical binding]; other site 1302650003750 catalytic Zn binding site [ion binding]; other site 1302650003751 structural Zn binding site [ion binding]; other site 1302650003752 mannonate dehydratase; Provisional; Region: PRK03906 1302650003753 mannonate dehydratase; Region: uxuA; TIGR00695 1302650003754 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1302650003755 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1302650003756 putative NAD(P) binding site [chemical binding]; other site 1302650003757 active site 1302650003758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650003759 D-galactonate transporter; Region: 2A0114; TIGR00893 1302650003760 putative substrate translocation pore; other site 1302650003761 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650003762 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650003763 DNA binding site [nucleotide binding] 1302650003764 domain linker motif; other site 1302650003765 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1302650003766 dimerization interface [polypeptide binding]; other site 1302650003767 ligand binding site [chemical binding]; other site 1302650003768 altronate oxidoreductase; Provisional; Region: PRK03643 1302650003769 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1302650003770 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1302650003771 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1302650003772 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1302650003773 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1302650003774 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1302650003775 DinB family; Region: DinB; pfam05163 1302650003776 DinB superfamily; Region: DinB_2; pfam12867 1302650003777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650003778 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302650003779 Walker A motif; other site 1302650003780 ATP binding site [chemical binding]; other site 1302650003781 Walker B motif; other site 1302650003782 arginine finger; other site 1302650003783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650003784 binding surface 1302650003785 TPR motif; other site 1302650003786 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650003787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650003788 binding surface 1302650003789 TPR motif; other site 1302650003790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1302650003791 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1302650003792 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1302650003793 amidase catalytic site [active] 1302650003794 Zn binding residues [ion binding]; other site 1302650003795 substrate binding site [chemical binding]; other site 1302650003796 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1302650003797 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650003798 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1302650003799 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1302650003800 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1302650003801 pentamer interface [polypeptide binding]; other site 1302650003802 dodecaamer interface [polypeptide binding]; other site 1302650003803 Phage-related replication protein [General function prediction only]; Region: COG4195 1302650003804 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1302650003805 dimanganese center [ion binding]; other site 1302650003806 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1302650003807 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302650003808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650003809 non-specific DNA binding site [nucleotide binding]; other site 1302650003810 salt bridge; other site 1302650003811 sequence-specific DNA binding site [nucleotide binding]; other site 1302650003812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1302650003813 putative Zn2+ binding site [ion binding]; other site 1302650003814 putative DNA binding site [nucleotide binding]; other site 1302650003815 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302650003816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650003817 Walker A motif; other site 1302650003818 ATP binding site [chemical binding]; other site 1302650003819 Walker B motif; other site 1302650003820 positive control sigma-like factor; Validated; Region: PRK06930 1302650003821 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650003822 DNA binding residues [nucleotide binding] 1302650003823 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1302650003824 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1302650003825 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1302650003826 Terminase-like family; Region: Terminase_6; pfam03237 1302650003827 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1302650003828 Phage capsid family; Region: Phage_capsid; pfam05065 1302650003829 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1302650003830 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1302650003831 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1302650003832 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1302650003833 Phage XkdN-like protein; Region: XkdN; pfam08890 1302650003834 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1302650003835 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1302650003836 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1302650003837 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1302650003838 catalytic residue [active] 1302650003839 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1302650003840 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650003841 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1302650003842 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1302650003843 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1302650003844 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1302650003845 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1302650003846 XkdW protein; Region: XkdW; pfam09636 1302650003847 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1302650003848 Haemolysin XhlA; Region: XhlA; pfam10779 1302650003849 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1302650003850 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1302650003851 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1302650003852 amidase catalytic site [active] 1302650003853 Zn binding residues [ion binding]; other site 1302650003854 substrate binding site [chemical binding]; other site 1302650003855 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1302650003856 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650003857 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1302650003858 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1302650003859 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1302650003860 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1302650003861 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1302650003862 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1302650003863 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1302650003864 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1302650003865 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650003866 Zn binding site [ion binding]; other site 1302650003867 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1302650003868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650003869 Zn binding site [ion binding]; other site 1302650003870 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1302650003871 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1302650003872 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1302650003873 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1302650003874 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1302650003875 Ligand binding site; other site 1302650003876 Putative Catalytic site; other site 1302650003877 DXD motif; other site 1302650003878 Trypsin; Region: Trypsin; pfam00089 1302650003879 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1302650003880 protein binding site [polypeptide binding]; other site 1302650003881 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 1302650003882 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1302650003883 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1302650003884 SxDxEG motif; other site 1302650003885 active site 1302650003886 metal binding site [ion binding]; metal-binding site 1302650003887 homopentamer interface [polypeptide binding]; other site 1302650003888 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1302650003889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650003890 dimer interface [polypeptide binding]; other site 1302650003891 conserved gate region; other site 1302650003892 putative PBP binding loops; other site 1302650003893 ABC-ATPase subunit interface; other site 1302650003894 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1302650003895 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1302650003896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650003897 dimer interface [polypeptide binding]; other site 1302650003898 conserved gate region; other site 1302650003899 putative PBP binding loops; other site 1302650003900 ABC-ATPase subunit interface; other site 1302650003901 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1302650003902 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1302650003903 Walker A/P-loop; other site 1302650003904 ATP binding site [chemical binding]; other site 1302650003905 Q-loop/lid; other site 1302650003906 ABC transporter signature motif; other site 1302650003907 Walker B; other site 1302650003908 D-loop; other site 1302650003909 H-loop/switch region; other site 1302650003910 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1302650003911 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1302650003912 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1302650003913 peptide binding site [polypeptide binding]; other site 1302650003914 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1302650003915 dimer interface [polypeptide binding]; other site 1302650003916 catalytic triad [active] 1302650003917 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1302650003918 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1302650003919 active site 1302650003920 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1302650003921 NlpC/P60 family; Region: NLPC_P60; pfam00877 1302650003922 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1302650003923 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1302650003924 Walker A/P-loop; other site 1302650003925 ATP binding site [chemical binding]; other site 1302650003926 Q-loop/lid; other site 1302650003927 ABC transporter signature motif; other site 1302650003928 Walker B; other site 1302650003929 D-loop; other site 1302650003930 H-loop/switch region; other site 1302650003931 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1302650003932 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1302650003933 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1302650003934 Amidinotransferase; Region: Amidinotransf; pfam02274 1302650003935 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1302650003936 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1302650003937 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1302650003938 heme-binding site [chemical binding]; other site 1302650003939 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1302650003940 FAD binding pocket [chemical binding]; other site 1302650003941 FAD binding motif [chemical binding]; other site 1302650003942 phosphate binding motif [ion binding]; other site 1302650003943 beta-alpha-beta structure motif; other site 1302650003944 NAD binding pocket [chemical binding]; other site 1302650003945 Heme binding pocket [chemical binding]; other site 1302650003946 Predicted membrane protein [Function unknown]; Region: COG2323 1302650003947 DinB superfamily; Region: DinB_2; pfam12867 1302650003948 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302650003949 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302650003950 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1302650003951 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1302650003952 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1302650003953 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1302650003954 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1302650003955 putative active site [active] 1302650003956 putative substrate binding site [chemical binding]; other site 1302650003957 putative cosubstrate binding site; other site 1302650003958 catalytic site [active] 1302650003959 glutamate 5-kinase; Region: proB; TIGR01027 1302650003960 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1302650003961 nucleotide binding site [chemical binding]; other site 1302650003962 homotetrameric interface [polypeptide binding]; other site 1302650003963 putative phosphate binding site [ion binding]; other site 1302650003964 putative allosteric binding site; other site 1302650003965 PUA domain; Region: PUA; pfam01472 1302650003966 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1302650003967 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1302650003968 putative catalytic cysteine [active] 1302650003969 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1302650003970 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1302650003971 MarR family; Region: MarR; pfam01047 1302650003972 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1302650003973 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1302650003974 nucleoside/Zn binding site; other site 1302650003975 dimer interface [polypeptide binding]; other site 1302650003976 catalytic motif [active] 1302650003977 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1302650003978 catalytic core [active] 1302650003979 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1302650003980 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1302650003981 THF binding site; other site 1302650003982 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1302650003983 substrate binding site [chemical binding]; other site 1302650003984 THF binding site; other site 1302650003985 zinc-binding site [ion binding]; other site 1302650003986 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1302650003987 active site 1302650003988 catalytic residues [active] 1302650003989 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1302650003990 Cobalt transport protein; Region: CbiQ; pfam02361 1302650003991 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1302650003992 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1302650003993 Walker A/P-loop; other site 1302650003994 ATP binding site [chemical binding]; other site 1302650003995 Q-loop/lid; other site 1302650003996 ABC transporter signature motif; other site 1302650003997 Walker B; other site 1302650003998 D-loop; other site 1302650003999 H-loop/switch region; other site 1302650004000 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1302650004001 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1302650004002 Walker A/P-loop; other site 1302650004003 ATP binding site [chemical binding]; other site 1302650004004 Q-loop/lid; other site 1302650004005 ABC transporter signature motif; other site 1302650004006 Walker B; other site 1302650004007 D-loop; other site 1302650004008 H-loop/switch region; other site 1302650004009 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1302650004010 YKOF-related Family; Region: Ykof; pfam07615 1302650004011 YKOF-related Family; Region: Ykof; pfam07615 1302650004012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650004013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650004014 active site 1302650004015 phosphorylation site [posttranslational modification] 1302650004016 intermolecular recognition site; other site 1302650004017 dimerization interface [polypeptide binding]; other site 1302650004018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650004019 DNA binding site [nucleotide binding] 1302650004020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650004021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650004022 dimerization interface [polypeptide binding]; other site 1302650004023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650004024 dimer interface [polypeptide binding]; other site 1302650004025 phosphorylation site [posttranslational modification] 1302650004026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650004027 ATP binding site [chemical binding]; other site 1302650004028 Mg2+ binding site [ion binding]; other site 1302650004029 G-X-G motif; other site 1302650004030 Predicted membrane protein [Function unknown]; Region: COG3212 1302650004031 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1302650004032 Predicted membrane protein [Function unknown]; Region: COG3212 1302650004033 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1302650004034 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1302650004035 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1302650004036 MgtE intracellular N domain; Region: MgtE_N; smart00924 1302650004037 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1302650004038 Divalent cation transporter; Region: MgtE; pfam01769 1302650004039 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1302650004040 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1302650004041 DNA binding residues [nucleotide binding] 1302650004042 putative dimer interface [polypeptide binding]; other site 1302650004043 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650004044 MarR family; Region: MarR; pfam01047 1302650004045 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1302650004046 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1302650004047 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1302650004048 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1302650004049 putative active site [active] 1302650004050 putative metal binding site [ion binding]; other site 1302650004051 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1302650004052 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650004053 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1302650004054 Ligand binding site; other site 1302650004055 Putative Catalytic site; other site 1302650004056 DXD motif; other site 1302650004057 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1302650004058 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1302650004059 active site 1302650004060 DNA binding site [nucleotide binding] 1302650004061 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1302650004062 nucleotide binding site [chemical binding]; other site 1302650004063 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1302650004064 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1302650004065 putative DNA binding site [nucleotide binding]; other site 1302650004066 putative homodimer interface [polypeptide binding]; other site 1302650004067 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1302650004068 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1302650004069 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1302650004070 PAS domain; Region: PAS_9; pfam13426 1302650004071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1302650004072 metal binding site [ion binding]; metal-binding site 1302650004073 active site 1302650004074 I-site; other site 1302650004075 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1302650004076 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1302650004077 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1302650004078 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1302650004079 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1302650004080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650004081 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1302650004082 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1302650004083 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1302650004084 heat shock protein HtpX; Provisional; Region: PRK05457 1302650004085 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1302650004086 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1302650004087 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1302650004088 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1302650004089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650004090 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1302650004091 putative active site [active] 1302650004092 heme pocket [chemical binding]; other site 1302650004093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650004094 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1302650004095 putative active site [active] 1302650004096 heme pocket [chemical binding]; other site 1302650004097 PAS domain; Region: PAS; smart00091 1302650004098 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1302650004099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650004100 putative active site [active] 1302650004101 heme pocket [chemical binding]; other site 1302650004102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650004103 dimer interface [polypeptide binding]; other site 1302650004104 phosphorylation site [posttranslational modification] 1302650004105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650004106 ATP binding site [chemical binding]; other site 1302650004107 Mg2+ binding site [ion binding]; other site 1302650004108 G-X-G motif; other site 1302650004109 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1302650004110 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1302650004111 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1302650004112 DNA binding site [nucleotide binding] 1302650004113 active site 1302650004114 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1302650004115 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1302650004116 Predicted kinase [General function prediction only]; Region: COG4857 1302650004117 Phosphotransferase enzyme family; Region: APH; pfam01636 1302650004118 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1302650004119 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1302650004120 putative active site [active] 1302650004121 catalytic triad [active] 1302650004122 putative dimer interface [polypeptide binding]; other site 1302650004123 transaminase; Reviewed; Region: PRK08068 1302650004124 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650004125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650004126 homodimer interface [polypeptide binding]; other site 1302650004127 catalytic residue [active] 1302650004128 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1302650004129 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1302650004130 dimer interface [polypeptide binding]; other site 1302650004131 active site 1302650004132 catalytic residue [active] 1302650004133 metal binding site [ion binding]; metal-binding site 1302650004134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650004135 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1302650004136 motif II; other site 1302650004137 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1302650004138 intersubunit interface [polypeptide binding]; other site 1302650004139 active site 1302650004140 Zn2+ binding site [ion binding]; other site 1302650004141 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1302650004142 Cupin domain; Region: Cupin_2; pfam07883 1302650004143 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1302650004144 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1302650004145 Cache domain; Region: Cache_1; pfam02743 1302650004146 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1302650004147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650004148 dimer interface [polypeptide binding]; other site 1302650004149 phosphorylation site [posttranslational modification] 1302650004150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650004151 ATP binding site [chemical binding]; other site 1302650004152 Mg2+ binding site [ion binding]; other site 1302650004153 G-X-G motif; other site 1302650004154 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650004155 MarR family; Region: MarR; pfam01047 1302650004156 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1302650004157 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1302650004158 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1302650004159 ligand binding site [chemical binding]; other site 1302650004160 flagellar motor protein MotA; Validated; Region: PRK08124 1302650004161 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1302650004162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650004163 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302650004164 Walker A motif; other site 1302650004165 ATP binding site [chemical binding]; other site 1302650004166 Walker B motif; other site 1302650004167 arginine finger; other site 1302650004168 UvrB/uvrC motif; Region: UVR; pfam02151 1302650004169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650004170 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302650004171 Walker A motif; other site 1302650004172 ATP binding site [chemical binding]; other site 1302650004173 Walker B motif; other site 1302650004174 arginine finger; other site 1302650004175 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1302650004176 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1302650004177 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1302650004178 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1302650004179 Ligand Binding Site [chemical binding]; other site 1302650004180 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1302650004181 active site 1302650004182 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1302650004183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650004184 FeS/SAM binding site; other site 1302650004185 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1302650004186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1302650004187 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1302650004188 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1302650004189 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1302650004190 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650004191 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1302650004192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650004193 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1302650004194 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1302650004195 active site 1302650004196 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1302650004197 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1302650004198 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1302650004199 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1302650004200 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1302650004201 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1302650004202 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302650004203 catalytic residues [active] 1302650004204 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1302650004205 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302650004206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650004207 motif II; other site 1302650004208 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1302650004209 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1302650004210 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1302650004211 active site 1302650004212 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650004213 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650004214 DNA binding site [nucleotide binding] 1302650004215 domain linker motif; other site 1302650004216 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1302650004217 putative dimerization interface [polypeptide binding]; other site 1302650004218 putative ligand binding site [chemical binding]; other site 1302650004219 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1302650004220 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1302650004221 PRD domain; Region: PRD; pfam00874 1302650004222 PRD domain; Region: PRD; pfam00874 1302650004223 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302650004224 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1302650004225 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302650004226 active site turn [active] 1302650004227 phosphorylation site [posttranslational modification] 1302650004228 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1302650004229 HPr interaction site; other site 1302650004230 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1302650004231 active site 1302650004232 phosphorylation site [posttranslational modification] 1302650004233 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1302650004234 dimerization domain swap beta strand [polypeptide binding]; other site 1302650004235 regulatory protein interface [polypeptide binding]; other site 1302650004236 active site 1302650004237 regulatory phosphorylation site [posttranslational modification]; other site 1302650004238 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1302650004239 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1302650004240 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1302650004241 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1302650004242 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1302650004243 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1302650004244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650004245 FeS/SAM binding site; other site 1302650004246 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302650004247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650004248 Coenzyme A binding pocket [chemical binding]; other site 1302650004249 Cache domain; Region: Cache_1; pfam02743 1302650004250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650004251 dimerization interface [polypeptide binding]; other site 1302650004252 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1302650004253 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650004254 dimer interface [polypeptide binding]; other site 1302650004255 putative CheW interface [polypeptide binding]; other site 1302650004256 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1302650004257 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1302650004258 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1302650004259 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1302650004260 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302650004261 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302650004262 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1302650004263 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302650004264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650004265 putative active site [active] 1302650004266 heme pocket [chemical binding]; other site 1302650004267 PAS fold; Region: PAS; pfam00989 1302650004268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650004269 putative active site [active] 1302650004270 heme pocket [chemical binding]; other site 1302650004271 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1302650004272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650004273 putative active site [active] 1302650004274 heme pocket [chemical binding]; other site 1302650004275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650004276 dimer interface [polypeptide binding]; other site 1302650004277 phosphorylation site [posttranslational modification] 1302650004278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650004279 ATP binding site [chemical binding]; other site 1302650004280 Mg2+ binding site [ion binding]; other site 1302650004281 G-X-G motif; other site 1302650004282 aminotransferase A; Validated; Region: PRK07683 1302650004283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650004284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650004285 homodimer interface [polypeptide binding]; other site 1302650004286 catalytic residue [active] 1302650004287 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1302650004288 putative CheA interaction surface; other site 1302650004289 Response regulator receiver domain; Region: Response_reg; pfam00072 1302650004290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650004291 active site 1302650004292 phosphorylation site [posttranslational modification] 1302650004293 intermolecular recognition site; other site 1302650004294 dimerization interface [polypeptide binding]; other site 1302650004295 YkyB-like protein; Region: YkyB; pfam14177 1302650004296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650004297 H+ Antiporter protein; Region: 2A0121; TIGR00900 1302650004298 putative substrate translocation pore; other site 1302650004299 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650004300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1302650004301 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1302650004302 phosphodiesterase YaeI; Provisional; Region: PRK11340 1302650004303 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1302650004304 putative active site [active] 1302650004305 putative metal binding site [ion binding]; other site 1302650004306 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1302650004307 short chain dehydrogenase; Provisional; Region: PRK07677 1302650004308 NAD(P) binding site [chemical binding]; other site 1302650004309 substrate binding site [chemical binding]; other site 1302650004310 homotetramer interface [polypeptide binding]; other site 1302650004311 active site 1302650004312 homodimer interface [polypeptide binding]; other site 1302650004313 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1302650004314 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1302650004315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1302650004316 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1302650004317 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1302650004318 FOG: CBS domain [General function prediction only]; Region: COG0517 1302650004319 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1302650004320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650004321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650004322 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302650004323 dimerization interface [polypeptide binding]; other site 1302650004324 flavodoxin; Provisional; Region: PRK06703 1302650004325 BNR repeat-like domain; Region: BNR_2; pfam13088 1302650004326 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1302650004327 flavodoxin, short chain; Region: flav_short; TIGR01753 1302650004328 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1302650004329 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1302650004330 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1302650004331 active site 1302650004332 trimer interface [polypeptide binding]; other site 1302650004333 substrate binding site [chemical binding]; other site 1302650004334 CoA binding site [chemical binding]; other site 1302650004335 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1302650004336 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1302650004337 metal binding site [ion binding]; metal-binding site 1302650004338 putative dimer interface [polypeptide binding]; other site 1302650004339 hypothetical protein; Provisional; Region: PRK03094 1302650004340 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1302650004341 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1302650004342 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1302650004343 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1302650004344 dimer interface [polypeptide binding]; other site 1302650004345 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1302650004346 catalytic triad [active] 1302650004347 peroxidatic and resolving cysteines [active] 1302650004348 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1302650004349 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302650004350 catalytic residues [active] 1302650004351 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1302650004352 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1302650004353 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1302650004354 GTP binding site; other site 1302650004355 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1302650004356 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1302650004357 ATP binding site [chemical binding]; other site 1302650004358 substrate interface [chemical binding]; other site 1302650004359 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1302650004360 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1302650004361 dimer interface [polypeptide binding]; other site 1302650004362 putative functional site; other site 1302650004363 putative MPT binding site; other site 1302650004364 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1302650004365 Walker A motif; other site 1302650004366 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1302650004367 MoaE homodimer interface [polypeptide binding]; other site 1302650004368 MoaD interaction [polypeptide binding]; other site 1302650004369 active site residues [active] 1302650004370 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1302650004371 MoaE interaction surface [polypeptide binding]; other site 1302650004372 MoeB interaction surface [polypeptide binding]; other site 1302650004373 thiocarboxylated glycine; other site 1302650004374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302650004375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650004376 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1302650004377 Walker A/P-loop; other site 1302650004378 ATP binding site [chemical binding]; other site 1302650004379 Q-loop/lid; other site 1302650004380 ABC transporter signature motif; other site 1302650004381 Walker B; other site 1302650004382 D-loop; other site 1302650004383 H-loop/switch region; other site 1302650004384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302650004385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650004386 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1302650004387 Walker A/P-loop; other site 1302650004388 ATP binding site [chemical binding]; other site 1302650004389 Q-loop/lid; other site 1302650004390 ABC transporter signature motif; other site 1302650004391 Walker B; other site 1302650004392 D-loop; other site 1302650004393 H-loop/switch region; other site 1302650004394 Yip1 domain; Region: Yip1; pfam04893 1302650004395 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1302650004396 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1302650004397 HlyD family secretion protein; Region: HlyD_3; pfam13437 1302650004398 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302650004399 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302650004400 Walker A/P-loop; other site 1302650004401 ATP binding site [chemical binding]; other site 1302650004402 Q-loop/lid; other site 1302650004403 ABC transporter signature motif; other site 1302650004404 Walker B; other site 1302650004405 D-loop; other site 1302650004406 H-loop/switch region; other site 1302650004407 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1302650004408 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302650004409 FtsX-like permease family; Region: FtsX; pfam02687 1302650004410 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1302650004411 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1302650004412 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1302650004413 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1302650004414 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1302650004415 putative substrate binding site [chemical binding]; other site 1302650004416 putative ATP binding site [chemical binding]; other site 1302650004417 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1302650004418 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1302650004419 active site 1302650004420 phosphorylation site [posttranslational modification] 1302650004421 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1302650004422 active site 1302650004423 P-loop; other site 1302650004424 phosphorylation site [posttranslational modification] 1302650004425 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1302650004426 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1302650004427 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1302650004428 Catalytic site [active] 1302650004429 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1302650004430 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650004431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650004432 ABC transporter; Region: ABC_tran_2; pfam12848 1302650004433 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302650004434 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1302650004435 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1302650004436 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1302650004437 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1302650004438 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1302650004439 rod-share determining protein MreBH; Provisional; Region: PRK13929 1302650004440 MreB and similar proteins; Region: MreB_like; cd10225 1302650004441 nucleotide binding site [chemical binding]; other site 1302650004442 Mg binding site [ion binding]; other site 1302650004443 putative protofilament interaction site [polypeptide binding]; other site 1302650004444 RodZ interaction site [polypeptide binding]; other site 1302650004445 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1302650004446 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1302650004447 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1302650004448 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650004449 putative active site [active] 1302650004450 heme pocket [chemical binding]; other site 1302650004451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650004452 dimer interface [polypeptide binding]; other site 1302650004453 phosphorylation site [posttranslational modification] 1302650004454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650004455 ATP binding site [chemical binding]; other site 1302650004456 Mg2+ binding site [ion binding]; other site 1302650004457 G-X-G motif; other site 1302650004458 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1302650004459 putative active site pocket [active] 1302650004460 dimerization interface [polypeptide binding]; other site 1302650004461 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1302650004462 putative active site pocket [active] 1302650004463 dimerization interface [polypeptide binding]; other site 1302650004464 putative catalytic residue [active] 1302650004465 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1302650004466 TrkA-N domain; Region: TrkA_N; pfam02254 1302650004467 TrkA-C domain; Region: TrkA_C; pfam02080 1302650004468 adenine deaminase; Region: ade; TIGR01178 1302650004469 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1302650004470 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1302650004471 active site 1302650004472 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1302650004473 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1302650004474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1302650004475 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1302650004476 hypothetical protein; Provisional; Region: PRK13667 1302650004477 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1302650004478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650004479 active site 1302650004480 motif I; other site 1302650004481 motif II; other site 1302650004482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650004483 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1302650004484 active site 1302650004485 catalytic residues [active] 1302650004486 metal binding site [ion binding]; metal-binding site 1302650004487 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1302650004488 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1302650004489 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1302650004490 TPP-binding site [chemical binding]; other site 1302650004491 tetramer interface [polypeptide binding]; other site 1302650004492 heterodimer interface [polypeptide binding]; other site 1302650004493 phosphorylation loop region [posttranslational modification] 1302650004494 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1302650004495 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1302650004496 alpha subunit interface [polypeptide binding]; other site 1302650004497 TPP binding site [chemical binding]; other site 1302650004498 heterodimer interface [polypeptide binding]; other site 1302650004499 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1302650004500 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1302650004501 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1302650004502 E3 interaction surface; other site 1302650004503 lipoyl attachment site [posttranslational modification]; other site 1302650004504 e3 binding domain; Region: E3_binding; pfam02817 1302650004505 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1302650004506 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1302650004507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1302650004508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650004509 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1302650004510 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1302650004511 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1302650004512 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1302650004513 homodimer interface [polypeptide binding]; other site 1302650004514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650004515 catalytic residue [active] 1302650004516 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1302650004517 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1302650004518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1302650004519 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1302650004520 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1302650004521 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1302650004522 active site 1302650004523 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1302650004524 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1302650004525 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1302650004526 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1302650004527 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1302650004528 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1302650004529 active site 1302650004530 Zn binding site [ion binding]; other site 1302650004531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650004532 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1302650004533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650004534 DNA binding residues [nucleotide binding] 1302650004535 Putative zinc-finger; Region: zf-HC2; pfam13490 1302650004536 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1302650004537 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1302650004538 G1 box; other site 1302650004539 putative GEF interaction site [polypeptide binding]; other site 1302650004540 GTP/Mg2+ binding site [chemical binding]; other site 1302650004541 Switch I region; other site 1302650004542 G2 box; other site 1302650004543 G3 box; other site 1302650004544 Switch II region; other site 1302650004545 G4 box; other site 1302650004546 G5 box; other site 1302650004547 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1302650004548 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1302650004549 YlaH-like protein; Region: YlaH; pfam14036 1302650004550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 1302650004551 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1302650004552 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1302650004553 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1302650004554 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1302650004555 putative active site [active] 1302650004556 PhoH-like protein; Region: PhoH; pfam02562 1302650004557 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1302650004558 glutaminase A; Region: Gln_ase; TIGR03814 1302650004559 hypothetical protein; Provisional; Region: PRK13666 1302650004560 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1302650004561 pyruvate carboxylase; Reviewed; Region: PRK12999 1302650004562 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1302650004563 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1302650004564 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1302650004565 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1302650004566 active site 1302650004567 catalytic residues [active] 1302650004568 metal binding site [ion binding]; metal-binding site 1302650004569 homodimer binding site [polypeptide binding]; other site 1302650004570 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1302650004571 carboxyltransferase (CT) interaction site; other site 1302650004572 biotinylation site [posttranslational modification]; other site 1302650004573 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1302650004574 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1302650004575 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1302650004576 UbiA prenyltransferase family; Region: UbiA; pfam01040 1302650004577 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1302650004578 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1302650004579 Cytochrome c; Region: Cytochrom_C; pfam00034 1302650004580 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1302650004581 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1302650004582 D-pathway; other site 1302650004583 Putative ubiquinol binding site [chemical binding]; other site 1302650004584 Low-spin heme (heme b) binding site [chemical binding]; other site 1302650004585 Putative water exit pathway; other site 1302650004586 Binuclear center (heme o3/CuB) [ion binding]; other site 1302650004587 K-pathway; other site 1302650004588 Putative proton exit pathway; other site 1302650004589 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1302650004590 Subunit I/III interface [polypeptide binding]; other site 1302650004591 Subunit III/IV interface [polypeptide binding]; other site 1302650004592 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1302650004593 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1302650004594 YugN-like family; Region: YugN; pfam08868 1302650004595 FOG: CBS domain [General function prediction only]; Region: COG0517 1302650004596 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1302650004597 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1302650004598 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1302650004599 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1302650004600 Putative coat protein; Region: YlbD_coat; pfam14071 1302650004601 YlbE-like protein; Region: YlbE; pfam14003 1302650004602 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1302650004603 hypothetical protein; Provisional; Region: PRK02886 1302650004604 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1302650004605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650004606 S-adenosylmethionine binding site [chemical binding]; other site 1302650004607 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1302650004608 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1302650004609 active site 1302650004610 (T/H)XGH motif; other site 1302650004611 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1302650004612 Nucleoside recognition; Region: Gate; pfam07670 1302650004613 Nucleoside recognition; Region: Gate; pfam07670 1302650004614 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1302650004615 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1302650004616 nucleophile elbow; other site 1302650004617 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1302650004618 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1302650004619 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1302650004620 protein binding site [polypeptide binding]; other site 1302650004621 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1302650004622 hypothetical protein; Provisional; Region: PRK13670 1302650004623 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1302650004624 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1302650004625 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1302650004626 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1302650004627 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1302650004628 hypothetical protein; Provisional; Region: PRK13688 1302650004629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650004630 Coenzyme A binding pocket [chemical binding]; other site 1302650004631 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1302650004632 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1302650004633 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1302650004634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1302650004635 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1302650004636 mraZ protein; Region: TIGR00242 1302650004637 MraZ protein; Region: MraZ; pfam02381 1302650004638 MraZ protein; Region: MraZ; pfam02381 1302650004639 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1302650004640 MraW methylase family; Region: Methyltransf_5; pfam01795 1302650004641 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1302650004642 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1302650004643 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302650004644 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302650004645 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1302650004646 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1302650004647 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1302650004648 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302650004649 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302650004650 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1302650004651 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1302650004652 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1302650004653 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302650004654 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302650004655 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1302650004656 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1302650004657 Mg++ binding site [ion binding]; other site 1302650004658 putative catalytic motif [active] 1302650004659 putative substrate binding site [chemical binding]; other site 1302650004660 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1302650004661 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302650004662 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302650004663 stage V sporulation protein E; Region: spoVE; TIGR02615 1302650004664 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1302650004665 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1302650004666 active site 1302650004667 homodimer interface [polypeptide binding]; other site 1302650004668 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1302650004669 FAD binding domain; Region: FAD_binding_4; pfam01565 1302650004670 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1302650004671 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1302650004672 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1302650004673 Cell division protein FtsQ; Region: FtsQ; pfam03799 1302650004674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1302650004675 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1302650004676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1302650004677 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1302650004678 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1302650004679 cell division protein FtsA; Region: ftsA; TIGR01174 1302650004680 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302650004681 nucleotide binding site [chemical binding]; other site 1302650004682 Cell division protein FtsA; Region: FtsA; pfam14450 1302650004683 cell division protein FtsZ; Validated; Region: PRK09330 1302650004684 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1302650004685 nucleotide binding site [chemical binding]; other site 1302650004686 SulA interaction site; other site 1302650004687 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1302650004688 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1302650004689 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1302650004690 active site 1302650004691 catalytic triad [active] 1302650004692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1302650004693 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1302650004694 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1302650004695 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1302650004696 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1302650004697 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1302650004698 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1302650004699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650004700 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650004701 DNA binding residues [nucleotide binding] 1302650004702 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1302650004703 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650004704 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1302650004705 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650004706 DNA binding residues [nucleotide binding] 1302650004707 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1302650004708 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1302650004709 Walker A/P-loop; other site 1302650004710 ATP binding site [chemical binding]; other site 1302650004711 Q-loop/lid; other site 1302650004712 ABC transporter signature motif; other site 1302650004713 Walker B; other site 1302650004714 D-loop; other site 1302650004715 H-loop/switch region; other site 1302650004716 acetylornithine deacetylase; Validated; Region: PRK08596 1302650004717 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1302650004718 metal binding site [ion binding]; metal-binding site 1302650004719 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1302650004720 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1302650004721 uncharacterized protein, YfiH family; Region: TIGR00726 1302650004722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1302650004723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1302650004724 catalytic residue [active] 1302650004725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1302650004726 YGGT family; Region: YGGT; pfam02325 1302650004727 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1302650004728 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650004729 RNA binding surface [nucleotide binding]; other site 1302650004730 DivIVA protein; Region: DivIVA; pfam05103 1302650004731 DivIVA domain; Region: DivI1A_domain; TIGR03544 1302650004732 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1302650004733 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1302650004734 HIGH motif; other site 1302650004735 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1302650004736 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1302650004737 active site 1302650004738 KMSKS motif; other site 1302650004739 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1302650004740 tRNA binding surface [nucleotide binding]; other site 1302650004741 anticodon binding site; other site 1302650004742 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1302650004743 lipoprotein signal peptidase; Region: lspA; TIGR00077 1302650004744 lipoprotein signal peptidase; Provisional; Region: PRK14787 1302650004745 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1302650004746 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650004747 RNA binding surface [nucleotide binding]; other site 1302650004748 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1302650004749 active site 1302650004750 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1302650004751 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650004752 active site 1302650004753 uracil-xanthine permease; Region: ncs2; TIGR00801 1302650004754 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1302650004755 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1302650004756 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1302650004757 dihydroorotase; Validated; Region: pyrC; PRK09357 1302650004758 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1302650004759 active site 1302650004760 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1302650004761 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1302650004762 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1302650004763 catalytic site [active] 1302650004764 subunit interface [polypeptide binding]; other site 1302650004765 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1302650004766 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1302650004767 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1302650004768 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1302650004769 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1302650004770 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1302650004771 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1302650004772 IMP binding site; other site 1302650004773 dimer interface [polypeptide binding]; other site 1302650004774 interdomain contacts; other site 1302650004775 partial ornithine binding site; other site 1302650004776 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1302650004777 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1302650004778 FAD binding pocket [chemical binding]; other site 1302650004779 FAD binding motif [chemical binding]; other site 1302650004780 phosphate binding motif [ion binding]; other site 1302650004781 beta-alpha-beta structure motif; other site 1302650004782 NAD binding pocket [chemical binding]; other site 1302650004783 Iron coordination center [ion binding]; other site 1302650004784 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1302650004785 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1302650004786 heterodimer interface [polypeptide binding]; other site 1302650004787 active site 1302650004788 FMN binding site [chemical binding]; other site 1302650004789 homodimer interface [polypeptide binding]; other site 1302650004790 substrate binding site [chemical binding]; other site 1302650004791 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1302650004792 active site 1302650004793 dimer interface [polypeptide binding]; other site 1302650004794 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650004795 active site 1302650004796 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1302650004797 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1302650004798 Active Sites [active] 1302650004799 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1302650004800 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1302650004801 ATP-sulfurylase; Region: ATPS; cd00517 1302650004802 active site 1302650004803 HXXH motif; other site 1302650004804 flexible loop; other site 1302650004805 AAA domain; Region: AAA_33; pfam13671 1302650004806 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1302650004807 ligand-binding site [chemical binding]; other site 1302650004808 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1302650004809 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1302650004810 active site 1302650004811 SAM binding site [chemical binding]; other site 1302650004812 homodimer interface [polypeptide binding]; other site 1302650004813 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1302650004814 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1302650004815 putative active site [active] 1302650004816 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1302650004817 putative active site [active] 1302650004818 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1302650004819 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1302650004820 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1302650004821 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1302650004822 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1302650004823 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1302650004824 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302650004825 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1302650004826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650004827 motif II; other site 1302650004828 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1302650004829 TIGR00255 family protein; Region: TIGR00255 1302650004830 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1302650004831 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1302650004832 hypothetical protein; Provisional; Region: PRK04323 1302650004833 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1302650004834 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1302650004835 catalytic site [active] 1302650004836 G-X2-G-X-G-K; other site 1302650004837 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1302650004838 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1302650004839 Flavoprotein; Region: Flavoprotein; pfam02441 1302650004840 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1302650004841 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1302650004842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650004843 ATP binding site [chemical binding]; other site 1302650004844 putative Mg++ binding site [ion binding]; other site 1302650004845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650004846 nucleotide binding region [chemical binding]; other site 1302650004847 ATP-binding site [chemical binding]; other site 1302650004848 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1302650004849 active site 1302650004850 catalytic residues [active] 1302650004851 metal binding site [ion binding]; metal-binding site 1302650004852 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1302650004853 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1302650004854 putative active site [active] 1302650004855 substrate binding site [chemical binding]; other site 1302650004856 putative cosubstrate binding site; other site 1302650004857 catalytic site [active] 1302650004858 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1302650004859 substrate binding site [chemical binding]; other site 1302650004860 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1302650004861 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1302650004862 putative RNA binding site [nucleotide binding]; other site 1302650004863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650004864 S-adenosylmethionine binding site [chemical binding]; other site 1302650004865 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1302650004866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650004867 FeS/SAM binding site; other site 1302650004868 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1302650004869 Protein phosphatase 2C; Region: PP2C; pfam00481 1302650004870 active site 1302650004871 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1302650004872 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1302650004873 active site 1302650004874 ATP binding site [chemical binding]; other site 1302650004875 substrate binding site [chemical binding]; other site 1302650004876 activation loop (A-loop); other site 1302650004877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1302650004878 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1302650004879 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1302650004880 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1302650004881 GTPase RsgA; Reviewed; Region: PRK00098 1302650004882 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1302650004883 RNA binding site [nucleotide binding]; other site 1302650004884 homodimer interface [polypeptide binding]; other site 1302650004885 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1302650004886 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1302650004887 GTP/Mg2+ binding site [chemical binding]; other site 1302650004888 G4 box; other site 1302650004889 G5 box; other site 1302650004890 G1 box; other site 1302650004891 Switch I region; other site 1302650004892 G2 box; other site 1302650004893 G3 box; other site 1302650004894 Switch II region; other site 1302650004895 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1302650004896 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1302650004897 substrate binding site [chemical binding]; other site 1302650004898 hexamer interface [polypeptide binding]; other site 1302650004899 metal binding site [ion binding]; metal-binding site 1302650004900 Thiamine pyrophosphokinase; Region: TPK; cd07995 1302650004901 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1302650004902 active site 1302650004903 dimerization interface [polypeptide binding]; other site 1302650004904 thiamine binding site [chemical binding]; other site 1302650004905 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1302650004906 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1302650004907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1302650004908 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1302650004909 DAK2 domain; Region: Dak2; pfam02734 1302650004910 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1302650004911 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1302650004912 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1302650004913 putative L-serine binding site [chemical binding]; other site 1302650004914 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 1302650004915 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1302650004916 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1302650004917 Pathogenicity locus; Region: Cdd1; pfam11731 1302650004918 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1302650004919 generic binding surface II; other site 1302650004920 ssDNA binding site; other site 1302650004921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650004922 ATP binding site [chemical binding]; other site 1302650004923 putative Mg++ binding site [ion binding]; other site 1302650004924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650004925 nucleotide binding region [chemical binding]; other site 1302650004926 ATP-binding site [chemical binding]; other site 1302650004927 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1302650004928 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1302650004929 putative phosphate acyltransferase; Provisional; Region: PRK05331 1302650004930 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1302650004931 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1302650004932 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1302650004933 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1302650004934 NAD(P) binding site [chemical binding]; other site 1302650004935 homotetramer interface [polypeptide binding]; other site 1302650004936 homodimer interface [polypeptide binding]; other site 1302650004937 active site 1302650004938 acyl carrier protein; Provisional; Region: acpP; PRK00982 1302650004939 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1302650004940 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1302650004941 dimerization interface [polypeptide binding]; other site 1302650004942 active site 1302650004943 metal binding site [ion binding]; metal-binding site 1302650004944 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1302650004945 dsRNA binding site [nucleotide binding]; other site 1302650004946 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1302650004947 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1302650004948 Walker A/P-loop; other site 1302650004949 ATP binding site [chemical binding]; other site 1302650004950 Q-loop/lid; other site 1302650004951 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1302650004952 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1302650004953 ABC transporter signature motif; other site 1302650004954 Walker B; other site 1302650004955 D-loop; other site 1302650004956 H-loop/switch region; other site 1302650004957 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1302650004958 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1302650004959 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1302650004960 GTP binding site [chemical binding]; other site 1302650004961 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1302650004962 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1302650004963 putative DNA-binding protein; Validated; Region: PRK00118 1302650004964 signal recognition particle protein; Provisional; Region: PRK10867 1302650004965 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1302650004966 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1302650004967 P loop; other site 1302650004968 GTP binding site [chemical binding]; other site 1302650004969 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1302650004970 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1302650004971 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1302650004972 KH domain; Region: KH_4; pfam13083 1302650004973 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1302650004974 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1302650004975 RimM N-terminal domain; Region: RimM; pfam01782 1302650004976 PRC-barrel domain; Region: PRC; pfam05239 1302650004977 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1302650004978 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1302650004979 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1302650004980 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1302650004981 GTP/Mg2+ binding site [chemical binding]; other site 1302650004982 G4 box; other site 1302650004983 G5 box; other site 1302650004984 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1302650004985 G1 box; other site 1302650004986 G1 box; other site 1302650004987 GTP/Mg2+ binding site [chemical binding]; other site 1302650004988 Switch I region; other site 1302650004989 G2 box; other site 1302650004990 G2 box; other site 1302650004991 G3 box; other site 1302650004992 G3 box; other site 1302650004993 Switch II region; other site 1302650004994 Switch II region; other site 1302650004995 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1302650004996 RNA/DNA hybrid binding site [nucleotide binding]; other site 1302650004997 active site 1302650004998 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1302650004999 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1302650005000 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1302650005001 CoA-ligase; Region: Ligase_CoA; pfam00549 1302650005002 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1302650005003 CoA binding domain; Region: CoA_binding; smart00881 1302650005004 CoA-ligase; Region: Ligase_CoA; pfam00549 1302650005005 DNA protecting protein DprA; Region: dprA; TIGR00732 1302650005006 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1302650005007 DNA topoisomerase I; Validated; Region: PRK05582 1302650005008 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1302650005009 active site 1302650005010 interdomain interaction site; other site 1302650005011 putative metal-binding site [ion binding]; other site 1302650005012 nucleotide binding site [chemical binding]; other site 1302650005013 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1302650005014 domain I; other site 1302650005015 DNA binding groove [nucleotide binding] 1302650005016 phosphate binding site [ion binding]; other site 1302650005017 domain II; other site 1302650005018 domain III; other site 1302650005019 nucleotide binding site [chemical binding]; other site 1302650005020 catalytic site [active] 1302650005021 domain IV; other site 1302650005022 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1302650005023 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1302650005024 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1302650005025 Glucose inhibited division protein A; Region: GIDA; pfam01134 1302650005026 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1302650005027 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1302650005028 active site 1302650005029 Int/Topo IB signature motif; other site 1302650005030 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1302650005031 active site 1302650005032 HslU subunit interaction site [polypeptide binding]; other site 1302650005033 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1302650005034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650005035 Walker A motif; other site 1302650005036 ATP binding site [chemical binding]; other site 1302650005037 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1302650005038 Walker B motif; other site 1302650005039 arginine finger; other site 1302650005040 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1302650005041 transcriptional repressor CodY; Validated; Region: PRK04158 1302650005042 CodY GAF-like domain; Region: CodY; pfam06018 1302650005043 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1302650005044 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1302650005045 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1302650005046 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1302650005047 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1302650005048 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1302650005049 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1302650005050 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1302650005051 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1302650005052 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1302650005053 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1302650005054 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1302650005055 MgtE intracellular N domain; Region: MgtE_N; smart00924 1302650005056 FliG C-terminal domain; Region: FliG_C; pfam01706 1302650005057 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1302650005058 Flagellar assembly protein FliH; Region: FliH; pfam02108 1302650005059 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1302650005060 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1302650005061 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1302650005062 Walker A motif/ATP binding site; other site 1302650005063 Walker B motif; other site 1302650005064 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1302650005065 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1302650005066 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1302650005067 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1302650005068 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1302650005069 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1302650005070 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1302650005071 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1302650005072 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1302650005073 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1302650005074 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 1302650005075 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1302650005076 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1302650005077 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1302650005078 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1302650005079 flagellar motor switch protein; Validated; Region: PRK08119 1302650005080 CheC-like family; Region: CheC; pfam04509 1302650005081 CheC-like family; Region: CheC; pfam04509 1302650005082 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1302650005083 Response regulator receiver domain; Region: Response_reg; pfam00072 1302650005084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650005085 active site 1302650005086 phosphorylation site [posttranslational modification] 1302650005087 intermolecular recognition site; other site 1302650005088 dimerization interface [polypeptide binding]; other site 1302650005089 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1302650005090 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1302650005091 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1302650005092 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1302650005093 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1302650005094 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1302650005095 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1302650005096 FHIPEP family; Region: FHIPEP; pfam00771 1302650005097 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1302650005098 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1302650005099 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1302650005100 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1302650005101 P-loop; other site 1302650005102 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1302650005103 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1302650005104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650005105 active site 1302650005106 phosphorylation site [posttranslational modification] 1302650005107 intermolecular recognition site; other site 1302650005108 dimerization interface [polypeptide binding]; other site 1302650005109 CheB methylesterase; Region: CheB_methylest; pfam01339 1302650005110 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1302650005111 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1302650005112 putative binding surface; other site 1302650005113 active site 1302650005114 P2 response regulator binding domain; Region: P2; pfam07194 1302650005115 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1302650005116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650005117 ATP binding site [chemical binding]; other site 1302650005118 Mg2+ binding site [ion binding]; other site 1302650005119 G-X-G motif; other site 1302650005120 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1302650005121 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1302650005122 putative CheA interaction surface; other site 1302650005123 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1302650005124 CheC-like family; Region: CheC; pfam04509 1302650005125 CheC-like family; Region: CheC; pfam04509 1302650005126 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1302650005127 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1302650005128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650005129 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1302650005130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650005131 DNA binding residues [nucleotide binding] 1302650005132 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1302650005133 rRNA interaction site [nucleotide binding]; other site 1302650005134 S8 interaction site; other site 1302650005135 putative laminin-1 binding site; other site 1302650005136 elongation factor Ts; Provisional; Region: tsf; PRK09377 1302650005137 UBA/TS-N domain; Region: UBA; pfam00627 1302650005138 Elongation factor TS; Region: EF_TS; pfam00889 1302650005139 Elongation factor TS; Region: EF_TS; pfam00889 1302650005140 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1302650005141 putative nucleotide binding site [chemical binding]; other site 1302650005142 uridine monophosphate binding site [chemical binding]; other site 1302650005143 homohexameric interface [polypeptide binding]; other site 1302650005144 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1302650005145 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1302650005146 hinge region; other site 1302650005147 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1302650005148 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1302650005149 catalytic residue [active] 1302650005150 putative FPP diphosphate binding site; other site 1302650005151 putative FPP binding hydrophobic cleft; other site 1302650005152 dimer interface [polypeptide binding]; other site 1302650005153 putative IPP diphosphate binding site; other site 1302650005154 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1302650005155 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1302650005156 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1302650005157 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1302650005158 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1302650005159 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1302650005160 RIP metalloprotease RseP; Region: TIGR00054 1302650005161 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1302650005162 active site 1302650005163 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1302650005164 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1302650005165 protein binding site [polypeptide binding]; other site 1302650005166 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1302650005167 putative substrate binding region [chemical binding]; other site 1302650005168 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1302650005169 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1302650005170 dimer interface [polypeptide binding]; other site 1302650005171 motif 1; other site 1302650005172 active site 1302650005173 motif 2; other site 1302650005174 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1302650005175 putative deacylase active site [active] 1302650005176 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1302650005177 active site 1302650005178 motif 3; other site 1302650005179 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1302650005180 anticodon binding site; other site 1302650005181 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1302650005182 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1302650005183 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1302650005184 generic binding surface II; other site 1302650005185 generic binding surface I; other site 1302650005186 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1302650005187 active site 1302650005188 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1302650005189 active site 1302650005190 catalytic site [active] 1302650005191 substrate binding site [chemical binding]; other site 1302650005192 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1302650005193 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1302650005194 Sm and related proteins; Region: Sm_like; cl00259 1302650005195 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1302650005196 putative oligomer interface [polypeptide binding]; other site 1302650005197 putative RNA binding site [nucleotide binding]; other site 1302650005198 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1302650005199 NusA N-terminal domain; Region: NusA_N; pfam08529 1302650005200 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1302650005201 RNA binding site [nucleotide binding]; other site 1302650005202 homodimer interface [polypeptide binding]; other site 1302650005203 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1302650005204 G-X-X-G motif; other site 1302650005205 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1302650005206 G-X-X-G motif; other site 1302650005207 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1302650005208 putative RNA binding cleft [nucleotide binding]; other site 1302650005209 hypothetical protein; Provisional; Region: PRK07714 1302650005210 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1302650005211 translation initiation factor IF-2; Region: IF-2; TIGR00487 1302650005212 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1302650005213 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1302650005214 G1 box; other site 1302650005215 putative GEF interaction site [polypeptide binding]; other site 1302650005216 GTP/Mg2+ binding site [chemical binding]; other site 1302650005217 Switch I region; other site 1302650005218 G2 box; other site 1302650005219 G3 box; other site 1302650005220 Switch II region; other site 1302650005221 G4 box; other site 1302650005222 G5 box; other site 1302650005223 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1302650005224 Translation-initiation factor 2; Region: IF-2; pfam11987 1302650005225 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1302650005226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1302650005227 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1302650005228 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1302650005229 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1302650005230 RNA binding site [nucleotide binding]; other site 1302650005231 active site 1302650005232 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1302650005233 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1302650005234 active site 1302650005235 Riboflavin kinase; Region: Flavokinase; smart00904 1302650005236 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1302650005237 16S/18S rRNA binding site [nucleotide binding]; other site 1302650005238 S13e-L30e interaction site [polypeptide binding]; other site 1302650005239 25S rRNA binding site [nucleotide binding]; other site 1302650005240 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1302650005241 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1302650005242 RNase E interface [polypeptide binding]; other site 1302650005243 trimer interface [polypeptide binding]; other site 1302650005244 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1302650005245 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1302650005246 RNase E interface [polypeptide binding]; other site 1302650005247 trimer interface [polypeptide binding]; other site 1302650005248 active site 1302650005249 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1302650005250 putative nucleic acid binding region [nucleotide binding]; other site 1302650005251 G-X-X-G motif; other site 1302650005252 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1302650005253 RNA binding site [nucleotide binding]; other site 1302650005254 domain interface; other site 1302650005255 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1302650005256 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1302650005257 NodB motif; other site 1302650005258 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1302650005259 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1302650005260 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1302650005261 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1302650005262 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1302650005263 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1302650005264 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1302650005265 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1302650005266 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1302650005267 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1302650005268 aspartate kinase I; Reviewed; Region: PRK08210 1302650005269 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1302650005270 putative catalytic residues [active] 1302650005271 putative nucleotide binding site [chemical binding]; other site 1302650005272 putative aspartate binding site [chemical binding]; other site 1302650005273 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1302650005274 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1302650005275 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1302650005276 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1302650005277 dimer interface [polypeptide binding]; other site 1302650005278 active site 1302650005279 catalytic residue [active] 1302650005280 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1302650005281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302650005282 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1302650005283 Clp protease; Region: CLP_protease; pfam00574 1302650005284 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1302650005285 active site 1302650005286 YlzJ-like protein; Region: YlzJ; pfam14035 1302650005287 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1302650005288 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1302650005289 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1302650005290 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1302650005291 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1302650005292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650005293 DNA-binding site [nucleotide binding]; DNA binding site 1302650005294 UTRA domain; Region: UTRA; pfam07702 1302650005295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650005296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650005297 putative substrate translocation pore; other site 1302650005298 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1302650005299 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1302650005300 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1302650005301 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1302650005302 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1302650005303 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1302650005304 classical (c) SDRs; Region: SDR_c; cd05233 1302650005305 NAD(P) binding site [chemical binding]; other site 1302650005306 active site 1302650005307 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1302650005308 ACT domain; Region: ACT; pfam01842 1302650005309 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1302650005310 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1302650005311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650005312 non-specific DNA binding site [nucleotide binding]; other site 1302650005313 salt bridge; other site 1302650005314 sequence-specific DNA binding site [nucleotide binding]; other site 1302650005315 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1302650005316 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1302650005317 competence damage-inducible protein A; Provisional; Region: PRK00549 1302650005318 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1302650005319 putative MPT binding site; other site 1302650005320 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 1302650005321 recombinase A; Provisional; Region: recA; PRK09354 1302650005322 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1302650005323 hexamer interface [polypeptide binding]; other site 1302650005324 Walker A motif; other site 1302650005325 ATP binding site [chemical binding]; other site 1302650005326 Walker B motif; other site 1302650005327 Beta-lactamase; Region: Beta-lactamase; pfam00144 1302650005328 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1302650005329 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1302650005330 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1302650005331 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302650005332 Zn2+ binding site [ion binding]; other site 1302650005333 Mg2+ binding site [ion binding]; other site 1302650005334 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1302650005335 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1302650005336 putative active site [active] 1302650005337 metal binding site [ion binding]; metal-binding site 1302650005338 homodimer binding site [polypeptide binding]; other site 1302650005339 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1302650005340 Threonine dehydrogenase; Region: TDH; cd05281 1302650005341 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 1302650005342 structural Zn binding site [ion binding]; other site 1302650005343 catalytic Zn binding site [ion binding]; other site 1302650005344 tetramer interface [polypeptide binding]; other site 1302650005345 NADP binding site [chemical binding]; other site 1302650005346 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1302650005347 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1302650005348 substrate-cofactor binding pocket; other site 1302650005349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650005350 catalytic residue [active] 1302650005351 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1302650005352 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1302650005353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650005354 FeS/SAM binding site; other site 1302650005355 TRAM domain; Region: TRAM; pfam01938 1302650005356 Predicted membrane protein [Function unknown]; Region: COG4550 1302650005357 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1302650005358 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1302650005359 MutS domain I; Region: MutS_I; pfam01624 1302650005360 MutS domain II; Region: MutS_II; pfam05188 1302650005361 MutS domain III; Region: MutS_III; pfam05192 1302650005362 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1302650005363 Walker A/P-loop; other site 1302650005364 ATP binding site [chemical binding]; other site 1302650005365 Q-loop/lid; other site 1302650005366 ABC transporter signature motif; other site 1302650005367 Walker B; other site 1302650005368 D-loop; other site 1302650005369 H-loop/switch region; other site 1302650005370 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1302650005371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650005372 ATP binding site [chemical binding]; other site 1302650005373 Mg2+ binding site [ion binding]; other site 1302650005374 G-X-G motif; other site 1302650005375 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1302650005376 ATP binding site [chemical binding]; other site 1302650005377 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1302650005378 Regulatory protein YrvL; Region: YrvL; pfam14184 1302650005379 transcriptional regulator BetI; Validated; Region: PRK00767 1302650005380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650005381 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1302650005382 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1302650005383 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1302650005384 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1302650005385 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1302650005386 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1302650005387 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1302650005388 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1302650005389 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1302650005390 FMN binding site [chemical binding]; other site 1302650005391 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1302650005392 substrate binding site [chemical binding]; other site 1302650005393 putative catalytic residue [active] 1302650005394 acyl carrier protein; Validated; Region: PRK07117 1302650005395 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1302650005396 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1302650005397 dimer interface [polypeptide binding]; other site 1302650005398 active site 1302650005399 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1302650005400 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1302650005401 dimer interface [polypeptide binding]; other site 1302650005402 active site 1302650005403 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1302650005404 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1302650005405 substrate binding site [chemical binding]; other site 1302650005406 oxyanion hole (OAH) forming residues; other site 1302650005407 trimer interface [polypeptide binding]; other site 1302650005408 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1302650005409 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1302650005410 substrate binding site [chemical binding]; other site 1302650005411 oxyanion hole (OAH) forming residues; other site 1302650005412 trimer interface [polypeptide binding]; other site 1302650005413 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1302650005414 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1302650005415 acyl-activating enzyme (AAE) consensus motif; other site 1302650005416 putative AMP binding site [chemical binding]; other site 1302650005417 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005418 Condensation domain; Region: Condensation; pfam00668 1302650005419 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005420 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1302650005421 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1302650005422 acyl-activating enzyme (AAE) consensus motif; other site 1302650005423 AMP binding site [chemical binding]; other site 1302650005424 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005425 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1302650005426 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005427 active site 1302650005428 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1302650005429 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1302650005430 KR domain; Region: KR; pfam08659 1302650005431 putative NADP binding site [chemical binding]; other site 1302650005432 active site 1302650005433 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1302650005434 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1302650005435 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1302650005436 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005437 active site 1302650005438 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1302650005439 putative NADP binding site [chemical binding]; other site 1302650005440 active site 1302650005441 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005442 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005443 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1302650005444 active site 1302650005445 potential frameshift: common BLAST hit: gi|384175461|ref|YP_005556846.1| KR domain family 1302650005446 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1302650005447 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1302650005448 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1302650005449 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005450 active site 1302650005451 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1302650005452 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1302650005453 putative NADP binding site [chemical binding]; other site 1302650005454 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1302650005455 active site 1302650005456 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1302650005457 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005458 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1302650005459 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005460 active site 1302650005461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1302650005462 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1302650005463 putative NADP binding site [chemical binding]; other site 1302650005464 active site 1302650005465 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005466 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005467 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1302650005468 active site 1302650005469 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005470 Condensation domain; Region: Condensation; pfam00668 1302650005471 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005472 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1302650005473 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1302650005474 acyl-activating enzyme (AAE) consensus motif; other site 1302650005475 AMP binding site [chemical binding]; other site 1302650005476 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005477 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1302650005478 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005479 active site 1302650005480 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1302650005481 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1302650005482 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1302650005483 putative NADP binding site [chemical binding]; other site 1302650005484 active site 1302650005485 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1302650005486 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1302650005487 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005488 active site 1302650005489 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1302650005490 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1302650005491 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1302650005492 putative NADP binding site [chemical binding]; other site 1302650005493 active site 1302650005494 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1302650005495 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1302650005496 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005497 active site 1302650005498 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1302650005499 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1302650005500 putative NADP binding site [chemical binding]; other site 1302650005501 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1302650005502 active site 1302650005503 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1302650005504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650005505 S-adenosylmethionine binding site [chemical binding]; other site 1302650005506 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1302650005507 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005508 active site 1302650005509 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005510 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1302650005511 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1302650005512 active site 1302650005513 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005514 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1302650005515 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1302650005516 Cytochrome P450; Region: p450; cl12078 1302650005517 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302650005518 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1302650005519 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1302650005520 active site 1302650005521 catalytic triad [active] 1302650005522 WYL domain; Region: WYL; cl14852 1302650005523 Phage-related replication protein [General function prediction only]; Region: COG4195 1302650005524 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1302650005525 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1302650005526 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1302650005527 YmaF family; Region: YmaF; pfam12788 1302650005528 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1302650005529 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1302650005530 bacterial Hfq-like; Region: Hfq; cd01716 1302650005531 hexamer interface [polypeptide binding]; other site 1302650005532 Sm1 motif; other site 1302650005533 RNA binding site [nucleotide binding]; other site 1302650005534 Sm2 motif; other site 1302650005535 YmzC-like protein; Region: YmzC; pfam14157 1302650005536 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1302650005537 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1302650005538 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1302650005539 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1302650005540 active site 1302650005541 dimer interface [polypeptide binding]; other site 1302650005542 catalytic residues [active] 1302650005543 effector binding site; other site 1302650005544 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1302650005545 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1302650005546 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1302650005547 dimer interface [polypeptide binding]; other site 1302650005548 putative radical transfer pathway; other site 1302650005549 diiron center [ion binding]; other site 1302650005550 tyrosyl radical; other site 1302650005551 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1302650005552 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1302650005553 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1302650005554 active site 1302650005555 metal binding site [ion binding]; metal-binding site 1302650005556 Sporulation related domain; Region: SPOR; pfam05036 1302650005557 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1302650005558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650005559 Walker A motif; other site 1302650005560 ATP binding site [chemical binding]; other site 1302650005561 Walker B motif; other site 1302650005562 arginine finger; other site 1302650005563 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1302650005564 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1302650005565 HflX GTPase family; Region: HflX; cd01878 1302650005566 G1 box; other site 1302650005567 GTP/Mg2+ binding site [chemical binding]; other site 1302650005568 Switch I region; other site 1302650005569 G2 box; other site 1302650005570 G3 box; other site 1302650005571 Switch II region; other site 1302650005572 G4 box; other site 1302650005573 G5 box; other site 1302650005574 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1302650005575 Aluminium resistance protein; Region: Alum_res; pfam06838 1302650005576 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1302650005577 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1302650005578 DNA binding residues [nucleotide binding] 1302650005579 putative dimer interface [polypeptide binding]; other site 1302650005580 glutamine synthetase, type I; Region: GlnA; TIGR00653 1302650005581 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1302650005582 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1302650005583 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1302650005584 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1302650005585 LXG domain of WXG superfamily; Region: LXG; pfam04740 1302650005586 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1302650005587 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1302650005588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650005589 Coenzyme A binding pocket [chemical binding]; other site 1302650005590 CAAX protease self-immunity; Region: Abi; cl00558 1302650005591 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1302650005592 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1302650005593 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1302650005594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650005595 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1302650005596 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1302650005597 inhibitor binding site; inhibition site 1302650005598 active site 1302650005599 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1302650005600 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1302650005601 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1302650005602 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302650005603 nucleotide binding site [chemical binding]; other site 1302650005604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1302650005605 xylose isomerase; Provisional; Region: PRK05474 1302650005606 xylose isomerase; Region: xylose_isom_A; TIGR02630 1302650005607 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1302650005608 N- and C-terminal domain interface [polypeptide binding]; other site 1302650005609 D-xylulose kinase; Region: XylB; TIGR01312 1302650005610 active site 1302650005611 MgATP binding site [chemical binding]; other site 1302650005612 catalytic site [active] 1302650005613 metal binding site [ion binding]; metal-binding site 1302650005614 xylulose binding site [chemical binding]; other site 1302650005615 homodimer interface [polypeptide binding]; other site 1302650005616 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1302650005617 Staphylococcal nuclease homologues; Region: SNc; smart00318 1302650005618 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1302650005619 Catalytic site; other site 1302650005620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650005621 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1302650005622 putative substrate translocation pore; other site 1302650005623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650005624 alanine racemase; Region: alr; TIGR00492 1302650005625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1302650005626 active site 1302650005627 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1302650005628 dimer interface [polypeptide binding]; other site 1302650005629 substrate binding site [chemical binding]; other site 1302650005630 catalytic residues [active] 1302650005631 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1302650005632 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1302650005633 trimer interface [polypeptide binding]; other site 1302650005634 active site 1302650005635 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1302650005636 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1302650005637 dimerization interface [polypeptide binding]; other site 1302650005638 active site 1302650005639 Transposase domain (DUF772); Region: DUF772; pfam05598 1302650005640 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1302650005641 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1302650005642 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1302650005643 putative binding site; other site 1302650005644 putative dimer interface [polypeptide binding]; other site 1302650005645 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1302650005646 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1302650005647 putative hydrophobic ligand binding site [chemical binding]; other site 1302650005648 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1302650005649 Spore germination protein; Region: Spore_permease; pfam03845 1302650005650 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1302650005651 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1302650005652 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1302650005653 YndJ-like protein; Region: YndJ; pfam14158 1302650005654 Phage-related replication protein [General function prediction only]; Region: COG4195 1302650005655 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1302650005656 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1302650005657 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1302650005658 putative active site [active] 1302650005659 putative Mg binding site [ion binding]; other site 1302650005660 LexA repressor; Validated; Region: PRK00215 1302650005661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650005662 putative DNA binding site [nucleotide binding]; other site 1302650005663 putative Zn2+ binding site [ion binding]; other site 1302650005664 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1302650005665 Catalytic site [active] 1302650005666 cell division suppressor protein YneA; Provisional; Region: PRK14125 1302650005667 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650005668 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1302650005669 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1302650005670 catalytic residues [active] 1302650005671 catalytic nucleophile [active] 1302650005672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1302650005673 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1302650005674 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1302650005675 TPP-binding site [chemical binding]; other site 1302650005676 dimer interface [polypeptide binding]; other site 1302650005677 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1302650005678 PYR/PP interface [polypeptide binding]; other site 1302650005679 dimer interface [polypeptide binding]; other site 1302650005680 TPP binding site [chemical binding]; other site 1302650005681 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1302650005682 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1302650005683 hypothetical protein; Provisional; Region: PRK01844 1302650005684 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1302650005685 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1302650005686 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1302650005687 Response regulator receiver domain; Region: Response_reg; pfam00072 1302650005688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650005689 active site 1302650005690 phosphorylation site [posttranslational modification] 1302650005691 intermolecular recognition site; other site 1302650005692 dimerization interface [polypeptide binding]; other site 1302650005693 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1302650005694 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1302650005695 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1302650005696 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1302650005697 putative dimer interface [polypeptide binding]; other site 1302650005698 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1302650005699 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1302650005700 aconitate hydratase; Validated; Region: PRK09277 1302650005701 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1302650005702 substrate binding site [chemical binding]; other site 1302650005703 ligand binding site [chemical binding]; other site 1302650005704 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1302650005705 substrate binding site [chemical binding]; other site 1302650005706 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1302650005707 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1302650005708 catalytic residues [active] 1302650005709 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1302650005710 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1302650005711 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1302650005712 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1302650005713 active site 1302650005714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1302650005715 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1302650005716 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1302650005717 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1302650005718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650005719 ATP binding site [chemical binding]; other site 1302650005720 Mg2+ binding site [ion binding]; other site 1302650005721 G-X-G motif; other site 1302650005722 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1302650005723 anchoring element; other site 1302650005724 dimer interface [polypeptide binding]; other site 1302650005725 ATP binding site [chemical binding]; other site 1302650005726 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1302650005727 active site 1302650005728 putative metal-binding site [ion binding]; other site 1302650005729 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1302650005730 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1302650005731 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1302650005732 CAP-like domain; other site 1302650005733 active site 1302650005734 primary dimer interface [polypeptide binding]; other site 1302650005735 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650005736 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650005737 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650005738 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302650005739 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1302650005740 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1302650005741 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1302650005742 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1302650005743 Cellulose binding domain; Region: CBM_3; pfam00942 1302650005744 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1302650005745 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1302650005746 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1302650005747 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1302650005748 substrate binding site [chemical binding]; other site 1302650005749 active site 1302650005750 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1302650005751 metal binding site [ion binding]; metal-binding site 1302650005752 ligand binding site [chemical binding]; other site 1302650005753 Predicted membrane protein [Function unknown]; Region: COG2246 1302650005754 GtrA-like protein; Region: GtrA; pfam04138 1302650005755 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1302650005756 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1302650005757 active site 1302650005758 tetramer interface; other site 1302650005759 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1302650005760 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1302650005761 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1302650005762 DHH family; Region: DHH; pfam01368 1302650005763 DHHA1 domain; Region: DHHA1; pfam02272 1302650005764 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1302650005765 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1302650005766 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1302650005767 enoyl-CoA hydratase; Provisional; Region: PRK07657 1302650005768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1302650005769 substrate binding site [chemical binding]; other site 1302650005770 oxyanion hole (OAH) forming residues; other site 1302650005771 trimer interface [polypeptide binding]; other site 1302650005772 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1302650005773 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1302650005774 active site 1302650005775 catalytic residues [active] 1302650005776 metal binding site [ion binding]; metal-binding site 1302650005777 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1302650005778 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1302650005779 carboxyltransferase (CT) interaction site; other site 1302650005780 biotinylation site [posttranslational modification]; other site 1302650005781 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1302650005782 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1302650005783 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1302650005784 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1302650005785 AMP-binding domain protein; Validated; Region: PRK08315 1302650005786 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1302650005787 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1302650005788 acyl-activating enzyme (AAE) consensus motif; other site 1302650005789 putative AMP binding site [chemical binding]; other site 1302650005790 putative active site [active] 1302650005791 putative CoA binding site [chemical binding]; other site 1302650005792 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1302650005793 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1302650005794 active site 1302650005795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1302650005796 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1302650005797 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1302650005798 Condensation domain; Region: Condensation; pfam00668 1302650005799 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005800 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1302650005801 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1302650005802 acyl-activating enzyme (AAE) consensus motif; other site 1302650005803 AMP binding site [chemical binding]; other site 1302650005804 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005805 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1302650005806 Condensation domain; Region: Condensation; pfam00668 1302650005807 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005808 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1302650005809 acyl-activating enzyme (AAE) consensus motif; other site 1302650005810 AMP binding site [chemical binding]; other site 1302650005811 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005812 Condensation domain; Region: Condensation; pfam00668 1302650005813 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005814 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1302650005815 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1302650005816 acyl-activating enzyme (AAE) consensus motif; other site 1302650005817 AMP binding site [chemical binding]; other site 1302650005818 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005819 Condensation domain; Region: Condensation; pfam00668 1302650005820 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005821 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1302650005822 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1302650005823 acyl-activating enzyme (AAE) consensus motif; other site 1302650005824 AMP binding site [chemical binding]; other site 1302650005825 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005826 Condensation domain; Region: Condensation; pfam00668 1302650005827 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1302650005828 potential frameshift: common BLAST hit: gi|384175601|ref|YP_005556986.1| amino acid adenylation domain protein 1302650005829 potential frameshift: common BLAST hit: gi|402776078|ref|YP_006630022.1| Plipastatin synthetase 1302650005830 Condensation domain; Region: Condensation; pfam00668 1302650005831 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005832 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1302650005833 acyl-activating enzyme (AAE) consensus motif; other site 1302650005834 AMP binding site [chemical binding]; other site 1302650005835 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005836 Condensation domain; Region: Condensation; pfam00668 1302650005837 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005838 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1302650005839 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1302650005840 acyl-activating enzyme (AAE) consensus motif; other site 1302650005841 AMP binding site [chemical binding]; other site 1302650005842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005843 Condensation domain; Region: Condensation; pfam00668 1302650005844 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005845 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1302650005846 Condensation domain; Region: Condensation; pfam00668 1302650005847 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005848 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1302650005849 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1302650005850 acyl-activating enzyme (AAE) consensus motif; other site 1302650005851 AMP binding site [chemical binding]; other site 1302650005852 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005853 Condensation domain; Region: Condensation; pfam00668 1302650005854 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005855 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1302650005856 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1302650005857 acyl-activating enzyme (AAE) consensus motif; other site 1302650005858 AMP binding site [chemical binding]; other site 1302650005859 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650005860 Condensation domain; Region: Condensation; pfam00668 1302650005861 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1302650005862 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1302650005863 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1302650005864 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1302650005865 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1302650005866 active site 1302650005867 catalytic residues [active] 1302650005868 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1302650005869 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1302650005870 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1302650005871 Int/Topo IB signature motif; other site 1302650005872 Helix-turn-helix domain; Region: HTH_17; cl17695 1302650005873 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1302650005874 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1302650005875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650005876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650005877 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1302650005878 putative dimerization interface [polypeptide binding]; other site 1302650005879 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1302650005880 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1302650005881 NAD(P) binding site [chemical binding]; other site 1302650005882 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1302650005883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1302650005884 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1302650005885 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1302650005886 active site 1302650005887 dimer interface [polypeptide binding]; other site 1302650005888 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1302650005889 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1302650005890 active site 1302650005891 FMN binding site [chemical binding]; other site 1302650005892 substrate binding site [chemical binding]; other site 1302650005893 3Fe-4S cluster binding site [ion binding]; other site 1302650005894 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1302650005895 domain interface; other site 1302650005896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650005897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650005898 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1302650005899 putative dimerization interface [polypeptide binding]; other site 1302650005900 gamma-glutamyl kinase; Provisional; Region: PRK13402 1302650005901 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1302650005902 nucleotide binding site [chemical binding]; other site 1302650005903 homotetrameric interface [polypeptide binding]; other site 1302650005904 putative phosphate binding site [ion binding]; other site 1302650005905 putative allosteric binding site; other site 1302650005906 PUA domain; Region: PUA; pfam01472 1302650005907 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1302650005908 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1302650005909 Replication terminator protein; Region: RTP; pfam02334 1302650005910 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1302650005911 classical (c) SDRs; Region: SDR_c; cd05233 1302650005912 NAD(P) binding site [chemical binding]; other site 1302650005913 active site 1302650005914 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1302650005915 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1302650005916 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302650005917 polyol permease family; Region: 2A0118; TIGR00897 1302650005918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650005919 putative substrate translocation pore; other site 1302650005920 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1302650005921 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1302650005922 putative N- and C-terminal domain interface [polypeptide binding]; other site 1302650005923 putative active site [active] 1302650005924 putative MgATP binding site [chemical binding]; other site 1302650005925 catalytic site [active] 1302650005926 metal binding site [ion binding]; metal-binding site 1302650005927 carbohydrate binding site [chemical binding]; other site 1302650005928 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1302650005929 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1302650005930 putative ligand binding site [chemical binding]; other site 1302650005931 putative NAD binding site [chemical binding]; other site 1302650005932 catalytic site [active] 1302650005933 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1302650005934 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1302650005935 putative [4Fe-4S] binding site [ion binding]; other site 1302650005936 putative molybdopterin cofactor binding site [chemical binding]; other site 1302650005937 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1302650005938 putative molybdopterin cofactor binding site; other site 1302650005939 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1302650005940 CHASE3 domain; Region: CHASE3; cl05000 1302650005941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650005942 dimerization interface [polypeptide binding]; other site 1302650005943 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1302650005944 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650005945 dimer interface [polypeptide binding]; other site 1302650005946 putative CheW interface [polypeptide binding]; other site 1302650005947 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1302650005948 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1302650005949 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1302650005950 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1302650005951 Predicted membrane protein [Function unknown]; Region: COG3619 1302650005952 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1302650005953 Amb_all domain; Region: Amb_all; smart00656 1302650005954 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1302650005955 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1302650005956 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1302650005957 Cupin; Region: Cupin_1; smart00835 1302650005958 Cupin; Region: Cupin_1; smart00835 1302650005959 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1302650005960 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1302650005961 VanW like protein; Region: VanW; pfam04294 1302650005962 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1302650005963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650005964 salt bridge; other site 1302650005965 non-specific DNA binding site [nucleotide binding]; other site 1302650005966 sequence-specific DNA binding site [nucleotide binding]; other site 1302650005967 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1302650005968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650005969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650005970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302650005971 dimerization interface [polypeptide binding]; other site 1302650005972 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1302650005973 EamA-like transporter family; Region: EamA; pfam00892 1302650005974 EamA-like transporter family; Region: EamA; pfam00892 1302650005975 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1302650005976 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1302650005977 conserved cys residue [active] 1302650005978 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1302650005979 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1302650005980 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1302650005981 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1302650005982 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1302650005983 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1302650005984 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1302650005985 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1302650005986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1302650005987 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302650005988 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1302650005989 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1302650005990 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302650005991 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1302650005992 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1302650005993 dimer interface [polypeptide binding]; other site 1302650005994 putative tRNA-binding site [nucleotide binding]; other site 1302650005995 Cupin domain; Region: Cupin_2; pfam07883 1302650005996 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302650005997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650005998 WHG domain; Region: WHG; pfam13305 1302650005999 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302650006000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1302650006001 Predicted transcriptional regulator [Transcription]; Region: COG2378 1302650006002 HTH domain; Region: HTH_11; pfam08279 1302650006003 WYL domain; Region: WYL; pfam13280 1302650006004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650006005 dimerization interface [polypeptide binding]; other site 1302650006006 putative DNA binding site [nucleotide binding]; other site 1302650006007 putative Zn2+ binding site [ion binding]; other site 1302650006008 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1302650006009 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1302650006010 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1302650006011 catalytic residue [active] 1302650006012 Predicted membrane protein [Function unknown]; Region: COG2322 1302650006013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1302650006014 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1302650006015 putative dimer interface [polypeptide binding]; other site 1302650006016 catalytic triad [active] 1302650006017 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1302650006018 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1302650006019 putative di-iron ligands [ion binding]; other site 1302650006020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302650006021 Histidine kinase; Region: HisKA_3; pfam07730 1302650006022 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1302650006023 ATP binding site [chemical binding]; other site 1302650006024 Mg2+ binding site [ion binding]; other site 1302650006025 G-X-G motif; other site 1302650006026 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650006027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650006028 active site 1302650006029 phosphorylation site [posttranslational modification] 1302650006030 intermolecular recognition site; other site 1302650006031 dimerization interface [polypeptide binding]; other site 1302650006032 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650006033 DNA binding residues [nucleotide binding] 1302650006034 dimerization interface [polypeptide binding]; other site 1302650006035 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650006036 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650006037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1302650006038 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1302650006039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650006040 ATP binding site [chemical binding]; other site 1302650006041 putative Mg++ binding site [ion binding]; other site 1302650006042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650006043 nucleotide binding region [chemical binding]; other site 1302650006044 ATP-binding site [chemical binding]; other site 1302650006045 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1302650006046 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1302650006047 azoreductase; Provisional; Region: PRK13556 1302650006048 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1302650006049 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1302650006050 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1302650006051 putative dimer interface [polypeptide binding]; other site 1302650006052 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1302650006053 pentamer interface [polypeptide binding]; other site 1302650006054 dodecaamer interface [polypeptide binding]; other site 1302650006055 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1302650006056 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1302650006057 NAD(P) binding site [chemical binding]; other site 1302650006058 catalytic residues [active] 1302650006059 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1302650006060 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1302650006061 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1302650006062 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1302650006063 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1302650006064 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1302650006065 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1302650006066 Na2 binding site [ion binding]; other site 1302650006067 putative substrate binding site 1 [chemical binding]; other site 1302650006068 Na binding site 1 [ion binding]; other site 1302650006069 putative substrate binding site 2 [chemical binding]; other site 1302650006070 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1302650006071 Sodium Bile acid symporter family; Region: SBF; pfam01758 1302650006072 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1302650006073 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1302650006074 E3 interaction surface; other site 1302650006075 lipoyl attachment site [posttranslational modification]; other site 1302650006076 e3 binding domain; Region: E3_binding; pfam02817 1302650006077 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1302650006078 2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239 1302650006079 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1302650006080 TPP-binding site [chemical binding]; other site 1302650006081 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1302650006082 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1302650006083 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1302650006084 metal ion-dependent adhesion site (MIDAS); other site 1302650006085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650006086 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302650006087 Walker A motif; other site 1302650006088 ATP binding site [chemical binding]; other site 1302650006089 Walker B motif; other site 1302650006090 arginine finger; other site 1302650006091 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1302650006092 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1302650006093 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1302650006094 E-class dimer interface [polypeptide binding]; other site 1302650006095 P-class dimer interface [polypeptide binding]; other site 1302650006096 active site 1302650006097 Cu2+ binding site [ion binding]; other site 1302650006098 Zn2+ binding site [ion binding]; other site 1302650006099 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650006100 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650006101 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650006102 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650006103 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1302650006104 NlpC/P60 family; Region: NLPC_P60; pfam00877 1302650006105 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1302650006106 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1302650006107 active site 1302650006108 TDP-binding site; other site 1302650006109 acceptor substrate-binding pocket; other site 1302650006110 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1302650006111 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1302650006112 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1302650006113 multidrug efflux protein; Reviewed; Region: PRK01766 1302650006114 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1302650006115 cation binding site [ion binding]; other site 1302650006116 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1302650006117 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1302650006118 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1302650006119 rarD protein; Region: rarD; TIGR00688 1302650006120 EamA-like transporter family; Region: EamA; pfam00892 1302650006121 GntP family permease; Region: GntP_permease; pfam02447 1302650006122 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1302650006123 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1302650006124 Predicted transcriptional regulators [Transcription]; Region: COG1733 1302650006125 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650006126 dimerization interface [polypeptide binding]; other site 1302650006127 putative DNA binding site [nucleotide binding]; other site 1302650006128 putative Zn2+ binding site [ion binding]; other site 1302650006129 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1302650006130 dimer interface [polypeptide binding]; other site 1302650006131 FMN binding site [chemical binding]; other site 1302650006132 Predicted esterase [General function prediction only]; Region: COG0400 1302650006133 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1302650006134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650006135 Zn binding site [ion binding]; other site 1302650006136 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1302650006137 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650006138 Zn binding site [ion binding]; other site 1302650006139 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1302650006140 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1302650006141 Na binding site [ion binding]; other site 1302650006142 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1302650006143 C-terminal peptidase (prc); Region: prc; TIGR00225 1302650006144 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1302650006145 protein binding site [polypeptide binding]; other site 1302650006146 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1302650006147 Catalytic dyad [active] 1302650006148 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1302650006149 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1302650006150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650006151 S-adenosylmethionine binding site [chemical binding]; other site 1302650006152 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1302650006153 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1302650006154 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1302650006155 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1302650006156 YodL-like; Region: YodL; pfam14191 1302650006157 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1302650006158 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1302650006159 active site 1302650006160 YozD-like protein; Region: YozD; pfam14162 1302650006161 hypothetical protein; Provisional; Region: PRK13672 1302650006162 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1302650006163 toxin interface [polypeptide binding]; other site 1302650006164 Zn binding site [ion binding]; other site 1302650006165 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1302650006166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650006167 FeS/SAM binding site; other site 1302650006168 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1302650006169 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1302650006170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650006171 Coenzyme A binding pocket [chemical binding]; other site 1302650006172 acetylornithine deacetylase; Validated; Region: PRK06915 1302650006173 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1302650006174 metal binding site [ion binding]; metal-binding site 1302650006175 dimer interface [polypeptide binding]; other site 1302650006176 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1302650006177 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1302650006178 hypothetical protein; Provisional; Region: PRK06917 1302650006179 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1302650006180 inhibitor-cofactor binding pocket; inhibition site 1302650006181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650006182 catalytic residue [active] 1302650006183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650006184 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302650006185 Coenzyme A binding pocket [chemical binding]; other site 1302650006186 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650006187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650006188 active site 1302650006189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1302650006190 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1302650006191 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1302650006192 Phytase; Region: Phytase; cl17685 1302650006193 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1302650006194 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1302650006195 NAD(P) binding site [chemical binding]; other site 1302650006196 homodimer interface [polypeptide binding]; other site 1302650006197 substrate binding site [chemical binding]; other site 1302650006198 active site 1302650006199 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1302650006200 SelR domain; Region: SelR; pfam01641 1302650006201 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1302650006202 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650006203 MarR family; Region: MarR; pfam01047 1302650006204 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1302650006205 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1302650006206 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1302650006207 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1302650006208 active site 1302650006209 catalytic triad [active] 1302650006210 oxyanion hole [active] 1302650006211 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1302650006212 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1302650006213 Cu(I) binding site [ion binding]; other site 1302650006214 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1302650006215 threonine dehydratase; Validated; Region: PRK08639 1302650006216 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1302650006217 tetramer interface [polypeptide binding]; other site 1302650006218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650006219 catalytic residue [active] 1302650006220 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1302650006221 putative Ile/Val binding site [chemical binding]; other site 1302650006222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650006223 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302650006224 Walker A motif; other site 1302650006225 ATP binding site [chemical binding]; other site 1302650006226 Walker B motif; other site 1302650006227 arginine finger; other site 1302650006228 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1302650006229 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1302650006230 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1302650006231 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1302650006232 putative acyl-acceptor binding pocket; other site 1302650006233 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1302650006234 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1302650006235 folate binding site [chemical binding]; other site 1302650006236 NADP+ binding site [chemical binding]; other site 1302650006237 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1302650006238 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1302650006239 dimerization interface [polypeptide binding]; other site 1302650006240 active site 1302650006241 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1302650006242 tetramer interfaces [polypeptide binding]; other site 1302650006243 binuclear metal-binding site [ion binding]; other site 1302650006244 YpjP-like protein; Region: YpjP; pfam14005 1302650006245 ribosomal biogenesis protein; Validated; Region: PRK00933 1302650006246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650006247 S-adenosylmethionine binding site [chemical binding]; other site 1302650006248 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1302650006249 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1302650006250 Transposase domain (DUF772); Region: DUF772; pfam05598 1302650006251 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1302650006252 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1302650006253 Virulence factor; Region: Virulence_fact; pfam13769 1302650006254 HEAT repeats; Region: HEAT_2; pfam13646 1302650006255 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1302650006256 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1302650006257 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1302650006258 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302650006259 Zn2+ binding site [ion binding]; other site 1302650006260 Mg2+ binding site [ion binding]; other site 1302650006261 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1302650006262 catalytic residues [active] 1302650006263 dimer interface [polypeptide binding]; other site 1302650006264 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1302650006265 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1302650006266 proposed active site lysine [active] 1302650006267 conserved cys residue [active] 1302650006268 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1302650006269 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1302650006270 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1302650006271 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1302650006272 DNA-binding site [nucleotide binding]; DNA binding site 1302650006273 RNA-binding motif; other site 1302650006274 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1302650006275 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1302650006276 hypothetical protein; Validated; Region: PRK07708 1302650006277 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1302650006278 RNA/DNA hybrid binding site [nucleotide binding]; other site 1302650006279 active site 1302650006280 conserved hypothetical integral membrane protein; Region: TIGR00697 1302650006281 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1302650006282 RNA/DNA hybrid binding site [nucleotide binding]; other site 1302650006283 active site 1302650006284 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1302650006285 5'-3' exonuclease; Region: 53EXOc; smart00475 1302650006286 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1302650006287 active site 1302650006288 metal binding site 1 [ion binding]; metal-binding site 1302650006289 putative 5' ssDNA interaction site; other site 1302650006290 metal binding site 3; metal-binding site 1302650006291 metal binding site 2 [ion binding]; metal-binding site 1302650006292 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1302650006293 putative DNA binding site [nucleotide binding]; other site 1302650006294 putative metal binding site [ion binding]; other site 1302650006295 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1302650006296 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1302650006297 Dynamin family; Region: Dynamin_N; pfam00350 1302650006298 G1 box; other site 1302650006299 GTP/Mg2+ binding site [chemical binding]; other site 1302650006300 G2 box; other site 1302650006301 Switch I region; other site 1302650006302 G3 box; other site 1302650006303 Switch II region; other site 1302650006304 G4 box; other site 1302650006305 G5 box; other site 1302650006306 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1302650006307 G1 box; other site 1302650006308 GTP/Mg2+ binding site [chemical binding]; other site 1302650006309 Dynamin family; Region: Dynamin_N; pfam00350 1302650006310 G2 box; other site 1302650006311 Switch I region; other site 1302650006312 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1302650006313 G3 box; other site 1302650006314 Switch II region; other site 1302650006315 GTP/Mg2+ binding site [chemical binding]; other site 1302650006316 G4 box; other site 1302650006317 G5 box; other site 1302650006318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1302650006319 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1302650006320 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1302650006321 malonyl-CoA binding site [chemical binding]; other site 1302650006322 dimer interface [polypeptide binding]; other site 1302650006323 active site 1302650006324 product binding site; other site 1302650006325 xanthine permease; Region: pbuX; TIGR03173 1302650006326 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1302650006327 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650006328 active site 1302650006329 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1302650006330 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1302650006331 active site 1302650006332 Zn binding site [ion binding]; other site 1302650006333 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1302650006334 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1302650006335 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1302650006336 active site 1302650006337 intersubunit interface [polypeptide binding]; other site 1302650006338 catalytic residue [active] 1302650006339 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1302650006340 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1302650006341 substrate binding site [chemical binding]; other site 1302650006342 ATP binding site [chemical binding]; other site 1302650006343 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650006344 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650006345 DNA binding site [nucleotide binding] 1302650006346 domain linker motif; other site 1302650006347 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1302650006348 putative dimerization interface [polypeptide binding]; other site 1302650006349 putative ligand binding site [chemical binding]; other site 1302650006350 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1302650006351 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1302650006352 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1302650006353 NADP binding site [chemical binding]; other site 1302650006354 homodimer interface [polypeptide binding]; other site 1302650006355 active site 1302650006356 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1302650006357 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1302650006358 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1302650006359 YpzG-like protein; Region: YpzG; pfam14139 1302650006360 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1302650006361 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1302650006362 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1302650006363 cell division protein GpsB; Provisional; Region: PRK14127 1302650006364 DivIVA domain; Region: DivI1A_domain; TIGR03544 1302650006365 hypothetical protein; Provisional; Region: PRK13660 1302650006366 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1302650006367 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1302650006368 RNase_H superfamily; Region: RNase_H_2; pfam13482 1302650006369 active site 1302650006370 substrate binding site [chemical binding]; other site 1302650006371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1302650006372 binding surface 1302650006373 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1302650006374 TPR motif; other site 1302650006375 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1302650006376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650006377 ATP binding site [chemical binding]; other site 1302650006378 putative Mg++ binding site [ion binding]; other site 1302650006379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650006380 nucleotide binding region [chemical binding]; other site 1302650006381 ATP-binding site [chemical binding]; other site 1302650006382 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1302650006383 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1302650006384 HPr interaction site; other site 1302650006385 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1302650006386 active site 1302650006387 phosphorylation site [posttranslational modification] 1302650006388 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1302650006389 YppG-like protein; Region: YppG; pfam14179 1302650006390 YppF-like protein; Region: YppF; pfam14178 1302650006391 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1302650006392 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1302650006393 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1302650006394 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1302650006395 Transglycosylase; Region: Transgly; pfam00912 1302650006396 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302650006397 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1302650006398 Interdomain contacts; other site 1302650006399 Cytokine receptor motif; other site 1302650006400 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1302650006401 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1302650006402 minor groove reading motif; other site 1302650006403 helix-hairpin-helix signature motif; other site 1302650006404 substrate binding pocket [chemical binding]; other site 1302650006405 active site 1302650006406 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1302650006407 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1302650006408 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1302650006409 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1302650006410 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1302650006411 putative dimer interface [polypeptide binding]; other site 1302650006412 putative anticodon binding site; other site 1302650006413 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1302650006414 homodimer interface [polypeptide binding]; other site 1302650006415 motif 1; other site 1302650006416 motif 2; other site 1302650006417 active site 1302650006418 motif 3; other site 1302650006419 aspartate aminotransferase; Provisional; Region: PRK05764 1302650006420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650006421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650006422 homodimer interface [polypeptide binding]; other site 1302650006423 catalytic residue [active] 1302650006424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1302650006425 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1302650006426 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1302650006427 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1302650006428 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1302650006429 active site 1302650006430 catalytic site [active] 1302650006431 substrate binding site [chemical binding]; other site 1302650006432 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1302650006433 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1302650006434 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1302650006435 tetramerization interface [polypeptide binding]; other site 1302650006436 active site 1302650006437 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1302650006438 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1302650006439 active site 1302650006440 ATP-binding site [chemical binding]; other site 1302650006441 pantoate-binding site; other site 1302650006442 HXXH motif; other site 1302650006443 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1302650006444 oligomerization interface [polypeptide binding]; other site 1302650006445 active site 1302650006446 metal binding site [ion binding]; metal-binding site 1302650006447 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1302650006448 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1302650006449 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1302650006450 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1302650006451 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1302650006452 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1302650006453 active site 1302650006454 NTP binding site [chemical binding]; other site 1302650006455 metal binding triad [ion binding]; metal-binding site 1302650006456 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1302650006457 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1302650006458 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1302650006459 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1302650006460 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1302650006461 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1302650006462 active site 1302650006463 dimer interfaces [polypeptide binding]; other site 1302650006464 catalytic residues [active] 1302650006465 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1302650006466 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1302650006467 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1302650006468 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1302650006469 homodimer interface [polypeptide binding]; other site 1302650006470 metal binding site [ion binding]; metal-binding site 1302650006471 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1302650006472 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650006473 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650006474 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1302650006475 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1302650006476 Predicted membrane protein [Function unknown]; Region: COG4347 1302650006477 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1302650006478 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1302650006479 intrachain domain interface; other site 1302650006480 Qi binding site; other site 1302650006481 Qo binding site; other site 1302650006482 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1302650006483 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1302650006484 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1302650006485 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1302650006486 interchain domain interface [polypeptide binding]; other site 1302650006487 intrachain domain interface; other site 1302650006488 heme bH binding site [chemical binding]; other site 1302650006489 Qi binding site; other site 1302650006490 heme bL binding site [chemical binding]; other site 1302650006491 Qo binding site; other site 1302650006492 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1302650006493 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1302650006494 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1302650006495 iron-sulfur cluster [ion binding]; other site 1302650006496 [2Fe-2S] cluster binding site [ion binding]; other site 1302650006497 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1302650006498 hypothetical protein; Provisional; Region: PRK03636 1302650006499 UPF0302 domain; Region: UPF0302; pfam08864 1302650006500 IDEAL domain; Region: IDEAL; pfam08858 1302650006501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650006502 TPR motif; other site 1302650006503 binding surface 1302650006504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650006505 binding surface 1302650006506 TPR motif; other site 1302650006507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650006508 TPR motif; other site 1302650006509 binding surface 1302650006510 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1302650006511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650006512 binding surface 1302650006513 TPR motif; other site 1302650006514 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1302650006515 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1302650006516 hinge; other site 1302650006517 active site 1302650006518 prephenate dehydrogenase; Validated; Region: PRK06545 1302650006519 prephenate dehydrogenase; Validated; Region: PRK08507 1302650006520 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1302650006521 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1302650006522 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650006523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650006524 homodimer interface [polypeptide binding]; other site 1302650006525 catalytic residue [active] 1302650006526 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1302650006527 substrate binding site [chemical binding]; other site 1302650006528 active site 1302650006529 catalytic residues [active] 1302650006530 heterodimer interface [polypeptide binding]; other site 1302650006531 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1302650006532 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1302650006533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650006534 catalytic residue [active] 1302650006535 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1302650006536 active site 1302650006537 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1302650006538 active site 1302650006539 ribulose/triose binding site [chemical binding]; other site 1302650006540 phosphate binding site [ion binding]; other site 1302650006541 substrate (anthranilate) binding pocket [chemical binding]; other site 1302650006542 product (indole) binding pocket [chemical binding]; other site 1302650006543 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1302650006544 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1302650006545 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1302650006546 anthranilate synthase component I; Provisional; Region: PRK13569 1302650006547 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1302650006548 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1302650006549 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1302650006550 homotrimer interaction site [polypeptide binding]; other site 1302650006551 active site 1302650006552 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1302650006553 active site 1302650006554 dimer interface [polypeptide binding]; other site 1302650006555 metal binding site [ion binding]; metal-binding site 1302650006556 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1302650006557 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1302650006558 Tetramer interface [polypeptide binding]; other site 1302650006559 active site 1302650006560 FMN-binding site [chemical binding]; other site 1302650006561 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1302650006562 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1302650006563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650006564 S-adenosylmethionine binding site [chemical binding]; other site 1302650006565 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1302650006566 active site 1302650006567 multimer interface [polypeptide binding]; other site 1302650006568 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1302650006569 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1302650006570 substrate binding pocket [chemical binding]; other site 1302650006571 chain length determination region; other site 1302650006572 substrate-Mg2+ binding site; other site 1302650006573 catalytic residues [active] 1302650006574 aspartate-rich region 1; other site 1302650006575 active site lid residues [active] 1302650006576 aspartate-rich region 2; other site 1302650006577 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1302650006578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650006579 S-adenosylmethionine binding site [chemical binding]; other site 1302650006580 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1302650006581 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1302650006582 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1302650006583 homodecamer interface [polypeptide binding]; other site 1302650006584 GTP cyclohydrolase I; Provisional; Region: PLN03044 1302650006585 active site 1302650006586 putative catalytic site residues [active] 1302650006587 zinc binding site [ion binding]; other site 1302650006588 GTP-CH-I/GFRP interaction surface; other site 1302650006589 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1302650006590 IHF dimer interface [polypeptide binding]; other site 1302650006591 IHF - DNA interface [nucleotide binding]; other site 1302650006592 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1302650006593 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1302650006594 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1302650006595 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1302650006596 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1302650006597 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1302650006598 GTP-binding protein Der; Reviewed; Region: PRK00093 1302650006599 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1302650006600 G1 box; other site 1302650006601 GTP/Mg2+ binding site [chemical binding]; other site 1302650006602 Switch I region; other site 1302650006603 G2 box; other site 1302650006604 Switch II region; other site 1302650006605 G3 box; other site 1302650006606 G4 box; other site 1302650006607 G5 box; other site 1302650006608 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1302650006609 G1 box; other site 1302650006610 GTP/Mg2+ binding site [chemical binding]; other site 1302650006611 Switch I region; other site 1302650006612 G2 box; other site 1302650006613 G3 box; other site 1302650006614 Switch II region; other site 1302650006615 G4 box; other site 1302650006616 G5 box; other site 1302650006617 YIEGIA protein; Region: YIEGIA; pfam14045 1302650006618 YpzI-like protein; Region: YpzI; pfam14140 1302650006619 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1302650006620 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1302650006621 homotetramer interface [polypeptide binding]; other site 1302650006622 FMN binding site [chemical binding]; other site 1302650006623 homodimer contacts [polypeptide binding]; other site 1302650006624 putative active site [active] 1302650006625 putative substrate binding site [chemical binding]; other site 1302650006626 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1302650006627 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1302650006628 RNA binding site [nucleotide binding]; other site 1302650006629 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1302650006630 RNA binding site [nucleotide binding]; other site 1302650006631 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1302650006632 RNA binding site [nucleotide binding]; other site 1302650006633 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1302650006634 RNA binding site [nucleotide binding]; other site 1302650006635 cytidylate kinase; Provisional; Region: cmk; PRK00023 1302650006636 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1302650006637 CMP-binding site; other site 1302650006638 The sites determining sugar specificity; other site 1302650006639 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1302650006640 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1302650006641 PilZ domain; Region: PilZ; pfam07238 1302650006642 germination protein YpeB; Region: spore_YpeB; TIGR02889 1302650006643 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1302650006644 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1302650006645 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1302650006646 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1302650006647 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1302650006648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650006649 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1302650006650 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1302650006651 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1302650006652 NAD(P) binding site [chemical binding]; other site 1302650006653 adaptor protein; Provisional; Region: PRK02899 1302650006654 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1302650006655 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1302650006656 putative active site [active] 1302650006657 putative metal binding site [ion binding]; other site 1302650006658 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1302650006659 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650006660 CAAX protease self-immunity; Region: Abi; pfam02517 1302650006661 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1302650006662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650006663 ATP binding site [chemical binding]; other site 1302650006664 putative Mg++ binding site [ion binding]; other site 1302650006665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650006666 nucleotide binding region [chemical binding]; other site 1302650006667 ATP-binding site [chemical binding]; other site 1302650006668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1302650006669 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1302650006670 Predicted membrane protein [Function unknown]; Region: COG3601 1302650006671 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1302650006672 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1302650006673 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1302650006674 ligand binding site [chemical binding]; other site 1302650006675 NAD binding site [chemical binding]; other site 1302650006676 dimerization interface [polypeptide binding]; other site 1302650006677 catalytic site [active] 1302650006678 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1302650006679 putative L-serine binding site [chemical binding]; other site 1302650006680 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1302650006681 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1302650006682 active site 1302650006683 catalytic residue [active] 1302650006684 dimer interface [polypeptide binding]; other site 1302650006685 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1302650006686 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650006687 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650006688 DNA binding residues [nucleotide binding] 1302650006689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1302650006690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650006691 dimerization interface [polypeptide binding]; other site 1302650006692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650006693 dimer interface [polypeptide binding]; other site 1302650006694 phosphorylation site [posttranslational modification] 1302650006695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650006696 ATP binding site [chemical binding]; other site 1302650006697 Mg2+ binding site [ion binding]; other site 1302650006698 G-X-G motif; other site 1302650006699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650006700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650006701 active site 1302650006702 phosphorylation site [posttranslational modification] 1302650006703 intermolecular recognition site; other site 1302650006704 dimerization interface [polypeptide binding]; other site 1302650006705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650006706 DNA binding site [nucleotide binding] 1302650006707 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1302650006708 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1302650006709 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1302650006710 ResB-like family; Region: ResB; pfam05140 1302650006711 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1302650006712 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302650006713 catalytic residues [active] 1302650006714 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1302650006715 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650006716 RNA binding surface [nucleotide binding]; other site 1302650006717 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1302650006718 active site 1302650006719 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1302650006720 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1302650006721 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1302650006722 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1302650006723 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1302650006724 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1302650006725 segregation and condensation protein B; Region: TIGR00281 1302650006726 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1302650006727 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1302650006728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650006729 Coenzyme A binding pocket [chemical binding]; other site 1302650006730 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1302650006731 homopentamer interface [polypeptide binding]; other site 1302650006732 active site 1302650006733 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1302650006734 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1302650006735 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1302650006736 dimerization interface [polypeptide binding]; other site 1302650006737 active site 1302650006738 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1302650006739 Lumazine binding domain; Region: Lum_binding; pfam00677 1302650006740 Lumazine binding domain; Region: Lum_binding; pfam00677 1302650006741 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1302650006742 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1302650006743 catalytic motif [active] 1302650006744 Zn binding site [ion binding]; other site 1302650006745 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1302650006746 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1302650006747 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1302650006748 Catalytic site [active] 1302650006749 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1302650006750 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1302650006751 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1302650006752 active site 1302650006753 Predicted secreted protein [Function unknown]; Region: COG4086 1302650006754 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1302650006755 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1302650006756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1302650006757 active site 1302650006758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1302650006759 substrate binding site [chemical binding]; other site 1302650006760 catalytic residues [active] 1302650006761 dimer interface [polypeptide binding]; other site 1302650006762 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1302650006763 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1302650006764 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1302650006765 stage V sporulation protein AD; Validated; Region: PRK08304 1302650006766 stage V sporulation protein AD; Provisional; Region: PRK12404 1302650006767 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1302650006768 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1302650006769 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1302650006770 sporulation sigma factor SigF; Validated; Region: PRK05572 1302650006771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650006772 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1302650006773 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650006774 DNA binding residues [nucleotide binding] 1302650006775 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1302650006776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650006777 ATP binding site [chemical binding]; other site 1302650006778 Mg2+ binding site [ion binding]; other site 1302650006779 G-X-G motif; other site 1302650006780 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1302650006781 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1302650006782 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1302650006783 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1302650006784 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1302650006785 phosphopentomutase; Provisional; Region: PRK05362 1302650006786 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1302650006787 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1302650006788 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1302650006789 active site 1302650006790 Int/Topo IB signature motif; other site 1302650006791 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1302650006792 ferric uptake regulator; Provisional; Region: fur; PRK09462 1302650006793 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1302650006794 metal binding site 2 [ion binding]; metal-binding site 1302650006795 putative DNA binding helix; other site 1302650006796 metal binding site 1 [ion binding]; metal-binding site 1302650006797 dimer interface [polypeptide binding]; other site 1302650006798 structural Zn2+ binding site [ion binding]; other site 1302650006799 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1302650006800 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1302650006801 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1302650006802 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1302650006803 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1302650006804 NAD(P) binding pocket [chemical binding]; other site 1302650006805 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1302650006806 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1302650006807 Aspartase; Region: Aspartase; cd01357 1302650006808 active sites [active] 1302650006809 tetramer interface [polypeptide binding]; other site 1302650006810 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1302650006811 active site 1302650006812 homodimer interface [polypeptide binding]; other site 1302650006813 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302650006814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650006815 non-specific DNA binding site [nucleotide binding]; other site 1302650006816 salt bridge; other site 1302650006817 sequence-specific DNA binding site [nucleotide binding]; other site 1302650006818 TIGR00375 family protein; Region: TIGR00375 1302650006819 PHP-associated; Region: PHP_C; pfam13263 1302650006820 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1302650006821 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1302650006822 dimer interface [polypeptide binding]; other site 1302650006823 ADP-ribose binding site [chemical binding]; other site 1302650006824 active site 1302650006825 nudix motif; other site 1302650006826 metal binding site [ion binding]; metal-binding site 1302650006827 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1302650006828 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302650006829 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302650006830 active site 1302650006831 catalytic tetrad [active] 1302650006832 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1302650006833 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1302650006834 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1302650006835 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1302650006836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1302650006837 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302650006838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650006839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1302650006840 Coenzyme A binding pocket [chemical binding]; other site 1302650006841 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1302650006842 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1302650006843 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1302650006844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650006845 Coenzyme A binding pocket [chemical binding]; other site 1302650006846 YolD-like protein; Region: YolD; pfam08863 1302650006847 DNA polymerase IV; Reviewed; Region: PRK03103 1302650006848 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1302650006849 active site 1302650006850 DNA binding site [nucleotide binding] 1302650006851 YqzH-like protein; Region: YqzH; pfam14164 1302650006852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650006853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650006854 putative substrate translocation pore; other site 1302650006855 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1302650006856 putative dimer interface [polypeptide binding]; other site 1302650006857 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650006858 ligand binding site [chemical binding]; other site 1302650006859 Zn binding site [ion binding]; other site 1302650006860 pantothenate kinase; Provisional; Region: PRK05439 1302650006861 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1302650006862 ATP-binding site [chemical binding]; other site 1302650006863 CoA-binding site [chemical binding]; other site 1302650006864 Mg2+-binding site [ion binding]; other site 1302650006865 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1302650006866 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1302650006867 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302650006868 catalytic residue [active] 1302650006869 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1302650006870 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1302650006871 NADP binding site [chemical binding]; other site 1302650006872 homodimer interface [polypeptide binding]; other site 1302650006873 substrate binding site [chemical binding]; other site 1302650006874 active site 1302650006875 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1302650006876 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1302650006877 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1302650006878 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1302650006879 putative metal binding site [ion binding]; other site 1302650006880 putative dimer interface [polypeptide binding]; other site 1302650006881 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1302650006882 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1302650006883 active site 1302650006884 FMN binding site [chemical binding]; other site 1302650006885 substrate binding site [chemical binding]; other site 1302650006886 homotetramer interface [polypeptide binding]; other site 1302650006887 catalytic residue [active] 1302650006888 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1302650006889 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1302650006890 putative hydrolase; Provisional; Region: PRK02113 1302650006891 ribonuclease Z; Region: RNase_Z; TIGR02651 1302650006892 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1302650006893 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1302650006894 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1302650006895 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1302650006896 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1302650006897 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1302650006898 DNA polymerase IV; Validated; Region: PRK01810 1302650006899 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1302650006900 active site 1302650006901 DNA binding site [nucleotide binding] 1302650006902 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1302650006903 OxaA-like protein precursor; Validated; Region: PRK01622 1302650006904 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 1302650006905 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1302650006906 peptidase T-like protein; Region: PepT-like; TIGR01883 1302650006907 metal binding site [ion binding]; metal-binding site 1302650006908 putative dimer interface [polypeptide binding]; other site 1302650006909 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1302650006910 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1302650006911 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1302650006912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650006913 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1302650006914 dimer interface [polypeptide binding]; other site 1302650006915 substrate binding site [chemical binding]; other site 1302650006916 metal binding site [ion binding]; metal-binding site 1302650006917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1302650006918 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1302650006919 Predicted membrane protein [Function unknown]; Region: COG4129 1302650006920 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1302650006921 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1302650006922 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302650006923 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1302650006924 Walker A/P-loop; other site 1302650006925 ATP binding site [chemical binding]; other site 1302650006926 Q-loop/lid; other site 1302650006927 ABC transporter signature motif; other site 1302650006928 Walker B; other site 1302650006929 D-loop; other site 1302650006930 H-loop/switch region; other site 1302650006931 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1302650006932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650006933 dimer interface [polypeptide binding]; other site 1302650006934 conserved gate region; other site 1302650006935 putative PBP binding loops; other site 1302650006936 ABC-ATPase subunit interface; other site 1302650006937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302650006938 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302650006939 substrate binding pocket [chemical binding]; other site 1302650006940 membrane-bound complex binding site; other site 1302650006941 hinge residues; other site 1302650006942 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1302650006943 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1302650006944 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1302650006945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650006946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650006947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1302650006948 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1302650006949 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1302650006950 DNA binding residues [nucleotide binding] 1302650006951 drug binding residues [chemical binding]; other site 1302650006952 dimer interface [polypeptide binding]; other site 1302650006953 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1302650006954 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1302650006955 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1302650006956 E3 interaction surface; other site 1302650006957 lipoyl attachment site [posttranslational modification]; other site 1302650006958 e3 binding domain; Region: E3_binding; pfam02817 1302650006959 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1302650006960 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1302650006961 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1302650006962 alpha subunit interface [polypeptide binding]; other site 1302650006963 TPP binding site [chemical binding]; other site 1302650006964 heterodimer interface [polypeptide binding]; other site 1302650006965 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1302650006966 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1302650006967 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1302650006968 tetramer interface [polypeptide binding]; other site 1302650006969 TPP-binding site [chemical binding]; other site 1302650006970 heterodimer interface [polypeptide binding]; other site 1302650006971 phosphorylation loop region [posttranslational modification] 1302650006972 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1302650006973 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1302650006974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650006975 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1302650006976 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302650006977 nucleotide binding site [chemical binding]; other site 1302650006978 Acetokinase family; Region: Acetate_kinase; cl17229 1302650006979 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1302650006980 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1302650006981 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1302650006982 NAD binding site [chemical binding]; other site 1302650006983 Phe binding site; other site 1302650006984 phosphate butyryltransferase; Validated; Region: PRK07742 1302650006985 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1302650006986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650006987 putative active site [active] 1302650006988 heme pocket [chemical binding]; other site 1302650006989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650006990 putative active site [active] 1302650006991 heme pocket [chemical binding]; other site 1302650006992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650006993 Walker A motif; other site 1302650006994 ATP binding site [chemical binding]; other site 1302650006995 Walker B motif; other site 1302650006996 arginine finger; other site 1302650006997 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1302650006998 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1302650006999 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1302650007000 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1302650007001 tetramer interface [polypeptide binding]; other site 1302650007002 active site 1302650007003 Mg2+/Mn2+ binding site [ion binding]; other site 1302650007004 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1302650007005 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1302650007006 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1302650007007 dimer interface [polypeptide binding]; other site 1302650007008 Citrate synthase; Region: Citrate_synt; pfam00285 1302650007009 active site 1302650007010 coenzyme A binding site [chemical binding]; other site 1302650007011 citrylCoA binding site [chemical binding]; other site 1302650007012 oxalacetate/citrate binding site [chemical binding]; other site 1302650007013 catalytic triad [active] 1302650007014 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1302650007015 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1302650007016 FAD binding site [chemical binding]; other site 1302650007017 homotetramer interface [polypeptide binding]; other site 1302650007018 substrate binding pocket [chemical binding]; other site 1302650007019 catalytic base [active] 1302650007020 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1302650007021 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1302650007022 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1302650007023 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1302650007024 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1302650007025 dimer interface [polypeptide binding]; other site 1302650007026 active site 1302650007027 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1302650007028 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1302650007029 active site 1302650007030 catalytic site [active] 1302650007031 metal binding site [ion binding]; metal-binding site 1302650007032 dimer interface [polypeptide binding]; other site 1302650007033 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1302650007034 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1302650007035 active site 1302650007036 metal binding site [ion binding]; metal-binding site 1302650007037 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1302650007038 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1302650007039 putative active site [active] 1302650007040 putative FMN binding site [chemical binding]; other site 1302650007041 putative substrate binding site [chemical binding]; other site 1302650007042 putative catalytic residue [active] 1302650007043 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1302650007044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650007045 active site 1302650007046 phosphorylation site [posttranslational modification] 1302650007047 intermolecular recognition site; other site 1302650007048 dimerization interface [polypeptide binding]; other site 1302650007049 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1302650007050 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1302650007051 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1302650007052 protein binding site [polypeptide binding]; other site 1302650007053 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1302650007054 DNA repair protein RecN; Region: recN; TIGR00634 1302650007055 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1302650007056 Walker A/P-loop; other site 1302650007057 ATP binding site [chemical binding]; other site 1302650007058 Q-loop/lid; other site 1302650007059 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1302650007060 ABC transporter signature motif; other site 1302650007061 Walker B; other site 1302650007062 D-loop; other site 1302650007063 H-loop/switch region; other site 1302650007064 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1302650007065 arginine repressor; Provisional; Region: PRK04280 1302650007066 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1302650007067 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1302650007068 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650007069 RNA binding surface [nucleotide binding]; other site 1302650007070 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1302650007071 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1302650007072 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1302650007073 TPP-binding site; other site 1302650007074 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1302650007075 PYR/PP interface [polypeptide binding]; other site 1302650007076 dimer interface [polypeptide binding]; other site 1302650007077 TPP binding site [chemical binding]; other site 1302650007078 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1302650007079 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1302650007080 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1302650007081 substrate binding pocket [chemical binding]; other site 1302650007082 chain length determination region; other site 1302650007083 substrate-Mg2+ binding site; other site 1302650007084 catalytic residues [active] 1302650007085 aspartate-rich region 1; other site 1302650007086 active site lid residues [active] 1302650007087 aspartate-rich region 2; other site 1302650007088 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1302650007089 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1302650007090 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1302650007091 generic binding surface II; other site 1302650007092 generic binding surface I; other site 1302650007093 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1302650007094 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1302650007095 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1302650007096 homodimer interface [polypeptide binding]; other site 1302650007097 NADP binding site [chemical binding]; other site 1302650007098 substrate binding site [chemical binding]; other site 1302650007099 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1302650007100 putative RNA binding site [nucleotide binding]; other site 1302650007101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1302650007102 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1302650007103 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1302650007104 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1302650007105 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1302650007106 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1302650007107 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1302650007108 carboxyltransferase (CT) interaction site; other site 1302650007109 biotinylation site [posttranslational modification]; other site 1302650007110 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1302650007111 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1302650007112 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1302650007113 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1302650007114 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1302650007115 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1302650007116 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1302650007117 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1302650007118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650007119 Walker A motif; other site 1302650007120 ATP binding site [chemical binding]; other site 1302650007121 Walker B motif; other site 1302650007122 arginine finger; other site 1302650007123 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1302650007124 elongation factor P; Validated; Region: PRK00529 1302650007125 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1302650007126 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1302650007127 RNA binding site [nucleotide binding]; other site 1302650007128 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1302650007129 RNA binding site [nucleotide binding]; other site 1302650007130 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1302650007131 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1302650007132 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1302650007133 active site 1302650007134 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1302650007135 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1302650007136 trimer interface [polypeptide binding]; other site 1302650007137 active site 1302650007138 dimer interface [polypeptide binding]; other site 1302650007139 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1302650007140 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1302650007141 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1302650007142 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1302650007143 active site 1302650007144 nucleophile elbow; other site 1302650007145 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1302650007146 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1302650007147 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1302650007148 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1302650007149 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1302650007150 active site residue [active] 1302650007151 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1302650007152 tetramer interface [polypeptide binding]; other site 1302650007153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650007154 catalytic residue [active] 1302650007155 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1302650007156 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1302650007157 tetramer interface [polypeptide binding]; other site 1302650007158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650007159 catalytic residue [active] 1302650007160 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1302650007161 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1302650007162 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1302650007163 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1302650007164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650007165 ATP binding site [chemical binding]; other site 1302650007166 putative Mg++ binding site [ion binding]; other site 1302650007167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650007168 nucleotide binding region [chemical binding]; other site 1302650007169 ATP-binding site [chemical binding]; other site 1302650007170 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1302650007171 Anti-repressor SinI; Region: SinI; pfam08671 1302650007172 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302650007173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650007174 non-specific DNA binding site [nucleotide binding]; other site 1302650007175 salt bridge; other site 1302650007176 sequence-specific DNA binding site [nucleotide binding]; other site 1302650007177 Anti-repressor SinI; Region: SinI; pfam08671 1302650007178 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1302650007179 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1302650007180 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1302650007181 Catalytic site [active] 1302650007182 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1302650007183 Merozoite surface protein (SPAM); Region: Merozoite_SPAM; pfam07133 1302650007184 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1302650007185 YqzE-like protein; Region: YqzE; pfam14038 1302650007186 ComG operon protein 7; Region: ComGG; pfam14173 1302650007187 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1302650007188 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1302650007189 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1302650007190 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1302650007191 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1302650007192 Type II/IV secretion system protein; Region: T2SE; pfam00437 1302650007193 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1302650007194 Walker A motif; other site 1302650007195 ATP binding site [chemical binding]; other site 1302650007196 Walker B motif; other site 1302650007197 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1302650007198 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1302650007199 Cl binding site [ion binding]; other site 1302650007200 oligomer interface [polypeptide binding]; other site 1302650007201 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1302650007202 Domain of unknown function DUF21; Region: DUF21; pfam01595 1302650007203 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1302650007204 Transporter associated domain; Region: CorC_HlyC; smart01091 1302650007205 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1302650007206 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1302650007207 ArsC family; Region: ArsC; pfam03960 1302650007208 putative catalytic residues [active] 1302650007209 thiol/disulfide switch; other site 1302650007210 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1302650007211 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302650007212 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1302650007213 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1302650007214 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1302650007215 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1302650007216 putative active site [active] 1302650007217 Zn binding site [ion binding]; other site 1302650007218 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1302650007219 Sulfatase; Region: Sulfatase; pfam00884 1302650007220 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1302650007221 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302650007222 nucleotide binding site [chemical binding]; other site 1302650007223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1302650007224 Rhomboid family; Region: Rhomboid; pfam01694 1302650007225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650007226 binding surface 1302650007227 TPR motif; other site 1302650007228 TPR repeat; Region: TPR_11; pfam13414 1302650007229 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1302650007230 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1302650007231 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1302650007232 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302650007233 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1302650007234 YceG-like family; Region: YceG; pfam02618 1302650007235 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1302650007236 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1302650007237 Walker A/P-loop; other site 1302650007238 ATP binding site [chemical binding]; other site 1302650007239 Q-loop/lid; other site 1302650007240 ABC transporter signature motif; other site 1302650007241 Walker B; other site 1302650007242 D-loop; other site 1302650007243 H-loop/switch region; other site 1302650007244 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1302650007245 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1302650007246 Walker A/P-loop; other site 1302650007247 ATP binding site [chemical binding]; other site 1302650007248 Q-loop/lid; other site 1302650007249 ABC transporter signature motif; other site 1302650007250 Walker B; other site 1302650007251 D-loop; other site 1302650007252 H-loop/switch region; other site 1302650007253 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1302650007254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650007255 dimer interface [polypeptide binding]; other site 1302650007256 conserved gate region; other site 1302650007257 ABC-ATPase subunit interface; other site 1302650007258 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1302650007259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650007260 dimer interface [polypeptide binding]; other site 1302650007261 conserved gate region; other site 1302650007262 putative PBP binding loops; other site 1302650007263 ABC-ATPase subunit interface; other site 1302650007264 PBP superfamily domain; Region: PBP_like_2; cl17296 1302650007265 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1302650007266 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1302650007267 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302650007268 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302650007269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650007270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650007271 putative substrate translocation pore; other site 1302650007272 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1302650007273 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1302650007274 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1302650007275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1302650007276 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1302650007277 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650007278 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1302650007279 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1302650007280 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1302650007281 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1302650007282 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1302650007283 ferric uptake regulator; Provisional; Region: fur; PRK09462 1302650007284 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1302650007285 metal binding site 2 [ion binding]; metal-binding site 1302650007286 putative DNA binding helix; other site 1302650007287 metal binding site 1 [ion binding]; metal-binding site 1302650007288 dimer interface [polypeptide binding]; other site 1302650007289 structural Zn2+ binding site [ion binding]; other site 1302650007290 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1302650007291 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650007292 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650007293 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1302650007294 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1302650007295 endonuclease IV; Provisional; Region: PRK01060 1302650007296 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1302650007297 AP (apurinic/apyrimidinic) site pocket; other site 1302650007298 DNA interaction; other site 1302650007299 Metal-binding active site; metal-binding site 1302650007300 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1302650007301 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1302650007302 ATP binding site [chemical binding]; other site 1302650007303 Mg++ binding site [ion binding]; other site 1302650007304 motif III; other site 1302650007305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650007306 nucleotide binding region [chemical binding]; other site 1302650007307 ATP-binding site [chemical binding]; other site 1302650007308 YqfQ-like protein; Region: YqfQ; pfam14181 1302650007309 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1302650007310 LytB protein; Region: LYTB; pfam02401 1302650007311 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1302650007312 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 1302650007313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1302650007314 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1302650007315 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1302650007316 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1302650007317 Family of unknown function (DUF633); Region: DUF633; pfam04816 1302650007318 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1302650007319 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1302650007320 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1302650007321 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1302650007322 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1302650007323 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650007324 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1302650007325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650007326 DNA binding residues [nucleotide binding] 1302650007327 DNA primase; Validated; Region: dnaG; PRK05667 1302650007328 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1302650007329 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1302650007330 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1302650007331 active site 1302650007332 metal binding site [ion binding]; metal-binding site 1302650007333 interdomain interaction site; other site 1302650007334 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1302650007335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1302650007336 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1302650007337 HTH domain; Region: HTH_11; pfam08279 1302650007338 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1302650007339 FOG: CBS domain [General function prediction only]; Region: COG0517 1302650007340 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1302650007341 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1302650007342 dimer interface [polypeptide binding]; other site 1302650007343 motif 1; other site 1302650007344 active site 1302650007345 motif 2; other site 1302650007346 motif 3; other site 1302650007347 Recombination protein O N terminal; Region: RecO_N; pfam11967 1302650007348 DNA repair protein RecO; Region: reco; TIGR00613 1302650007349 Recombination protein O C terminal; Region: RecO_C; pfam02565 1302650007350 YqzL-like protein; Region: YqzL; pfam14006 1302650007351 GTPase Era; Reviewed; Region: era; PRK00089 1302650007352 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1302650007353 G1 box; other site 1302650007354 GTP/Mg2+ binding site [chemical binding]; other site 1302650007355 Switch I region; other site 1302650007356 G2 box; other site 1302650007357 Switch II region; other site 1302650007358 G3 box; other site 1302650007359 G4 box; other site 1302650007360 G5 box; other site 1302650007361 KH domain; Region: KH_2; pfam07650 1302650007362 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1302650007363 active site 1302650007364 catalytic motif [active] 1302650007365 Zn binding site [ion binding]; other site 1302650007366 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1302650007367 metal-binding heat shock protein; Provisional; Region: PRK00016 1302650007368 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1302650007369 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1302650007370 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302650007371 Zn2+ binding site [ion binding]; other site 1302650007372 Mg2+ binding site [ion binding]; other site 1302650007373 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1302650007374 PhoH-like protein; Region: PhoH; pfam02562 1302650007375 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1302650007376 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1302650007377 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1302650007378 hypothetical protein; Provisional; Region: PRK13665 1302650007379 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1302650007380 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1302650007381 dimer interface [polypeptide binding]; other site 1302650007382 active site residues [active] 1302650007383 Yqey-like protein; Region: YqeY; pfam09424 1302650007384 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1302650007385 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1302650007386 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1302650007387 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1302650007388 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1302650007389 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1302650007390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650007391 FeS/SAM binding site; other site 1302650007392 TRAM domain; Region: TRAM; cl01282 1302650007393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1302650007394 RNA methyltransferase, RsmE family; Region: TIGR00046 1302650007395 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1302650007396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650007397 S-adenosylmethionine binding site [chemical binding]; other site 1302650007398 chaperone protein DnaJ; Provisional; Region: PRK14280 1302650007399 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1302650007400 HSP70 interaction site [polypeptide binding]; other site 1302650007401 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1302650007402 substrate binding site [polypeptide binding]; other site 1302650007403 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1302650007404 Zn binding sites [ion binding]; other site 1302650007405 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1302650007406 dimer interface [polypeptide binding]; other site 1302650007407 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1302650007408 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1302650007409 nucleotide binding site [chemical binding]; other site 1302650007410 NEF interaction site [polypeptide binding]; other site 1302650007411 SBD interface [polypeptide binding]; other site 1302650007412 GrpE; Region: GrpE; pfam01025 1302650007413 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1302650007414 dimer interface [polypeptide binding]; other site 1302650007415 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1302650007416 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1302650007417 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1302650007418 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1302650007419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650007420 FeS/SAM binding site; other site 1302650007421 HemN C-terminal domain; Region: HemN_C; pfam06969 1302650007422 GTP-binding protein LepA; Provisional; Region: PRK05433 1302650007423 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1302650007424 G1 box; other site 1302650007425 putative GEF interaction site [polypeptide binding]; other site 1302650007426 GTP/Mg2+ binding site [chemical binding]; other site 1302650007427 Switch I region; other site 1302650007428 G2 box; other site 1302650007429 G3 box; other site 1302650007430 Switch II region; other site 1302650007431 G4 box; other site 1302650007432 G5 box; other site 1302650007433 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1302650007434 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1302650007435 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1302650007436 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1302650007437 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1302650007438 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1302650007439 germination protease; Provisional; Region: PRK02858 1302650007440 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1302650007441 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1302650007442 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1302650007443 YqzM-like protein; Region: YqzM; pfam14141 1302650007444 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1302650007445 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1302650007446 Competence protein; Region: Competence; pfam03772 1302650007447 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302650007448 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1302650007449 catalytic motif [active] 1302650007450 Zn binding site [ion binding]; other site 1302650007451 SLBB domain; Region: SLBB; pfam10531 1302650007452 comEA protein; Region: comE; TIGR01259 1302650007453 Helix-hairpin-helix motif; Region: HHH; pfam00633 1302650007454 late competence protein ComER; Validated; Region: PRK07680 1302650007455 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1302650007456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650007457 S-adenosylmethionine binding site [chemical binding]; other site 1302650007458 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1302650007459 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302650007460 Zn2+ binding site [ion binding]; other site 1302650007461 Mg2+ binding site [ion binding]; other site 1302650007462 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1302650007463 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1302650007464 active site 1302650007465 (T/H)XGH motif; other site 1302650007466 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1302650007467 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1302650007468 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1302650007469 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1302650007470 shikimate binding site; other site 1302650007471 NAD(P) binding site [chemical binding]; other site 1302650007472 GTPase YqeH; Provisional; Region: PRK13796 1302650007473 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1302650007474 GTP/Mg2+ binding site [chemical binding]; other site 1302650007475 G4 box; other site 1302650007476 G5 box; other site 1302650007477 G1 box; other site 1302650007478 Switch I region; other site 1302650007479 G2 box; other site 1302650007480 G3 box; other site 1302650007481 Switch II region; other site 1302650007482 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1302650007483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650007484 active site 1302650007485 motif I; other site 1302650007486 motif II; other site 1302650007487 Sporulation inhibitor A; Region: Sda; pfam08970 1302650007488 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1302650007489 active site 1302650007490 catalytic triad [active] 1302650007491 oxyanion hole [active] 1302650007492 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1302650007493 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1302650007494 amidase catalytic site [active] 1302650007495 Zn binding residues [ion binding]; other site 1302650007496 substrate binding site [chemical binding]; other site 1302650007497 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1302650007498 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1302650007499 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1302650007500 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1302650007501 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1302650007502 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1302650007503 arginine decarboxylase; Provisional; Region: PRK15029 1302650007504 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1302650007505 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1302650007506 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650007507 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650007508 DNA binding residues [nucleotide binding] 1302650007509 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1302650007510 Predicted membrane protein [Function unknown]; Region: COG3223 1302650007511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650007512 HAMP domain; Region: HAMP; pfam00672 1302650007513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650007514 dimer interface [polypeptide binding]; other site 1302650007515 phosphorylation site [posttranslational modification] 1302650007516 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1302650007517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650007518 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1302650007519 active site 1302650007520 phosphorylation site [posttranslational modification] 1302650007521 intermolecular recognition site; other site 1302650007522 dimerization interface [polypeptide binding]; other site 1302650007523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650007524 DNA binding site [nucleotide binding] 1302650007525 Predicted membrane protein [Function unknown]; Region: COG2311 1302650007526 Protein of unknown function (DUF418); Region: DUF418; cl12135 1302650007527 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1302650007528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650007529 Coenzyme A binding pocket [chemical binding]; other site 1302650007530 Predicted transcriptional regulators [Transcription]; Region: COG1733 1302650007531 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1302650007532 short chain dehydrogenase; Provisional; Region: PRK06500 1302650007533 classical (c) SDRs; Region: SDR_c; cd05233 1302650007534 NAD(P) binding site [chemical binding]; other site 1302650007535 active site 1302650007536 EVE domain; Region: EVE; cl00728 1302650007537 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1302650007538 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302650007539 potential frameshift: common BLAST hit: gi|321312085|ref|YP_004204372.1| N-acetylmuramoyl-L-alanine amidase 1302650007540 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1302650007541 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1302650007542 Predicted transcriptional regulators [Transcription]; Region: COG1695 1302650007543 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1302650007544 hypothetical protein; Validated; Region: PRK06217 1302650007545 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1302650007546 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1302650007547 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1302650007548 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1302650007549 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650007550 MarR family; Region: MarR_2; pfam12802 1302650007551 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1302650007552 active site residue [active] 1302650007553 hypothetical protein; Provisional; Region: PRK02268 1302650007554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1302650007555 binding surface 1302650007556 TPR motif; other site 1302650007557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650007558 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650007559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650007560 binding surface 1302650007561 TPR motif; other site 1302650007562 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650007563 LXG domain of WXG superfamily; Region: LXG; pfam04740 1302650007564 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1302650007565 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302650007566 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 1302650007567 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1302650007568 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1302650007569 DNA binding residues [nucleotide binding] 1302650007570 dimer interface [polypeptide binding]; other site 1302650007571 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1302650007572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650007573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650007574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650007575 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302650007576 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1302650007577 Coenzyme A binding pocket [chemical binding]; other site 1302650007578 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1302650007579 Domain of unknown function DUF21; Region: DUF21; pfam01595 1302650007580 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1302650007581 Transporter associated domain; Region: CorC_HlyC; smart01091 1302650007582 YrzO-like protein; Region: YrzO; pfam14142 1302650007583 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1302650007584 EamA-like transporter family; Region: EamA; pfam00892 1302650007585 EamA-like transporter family; Region: EamA; pfam00892 1302650007586 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650007587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650007588 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1302650007589 putative dimerization interface [polypeptide binding]; other site 1302650007590 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1302650007591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1302650007592 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1302650007593 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1302650007594 Tautomerase enzyme; Region: Tautomerase; pfam01361 1302650007595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650007596 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1302650007597 putative dimerization interface [polypeptide binding]; other site 1302650007598 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1302650007599 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1302650007600 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1302650007601 4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346 1302650007602 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1302650007603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650007604 putative DNA binding site [nucleotide binding]; other site 1302650007605 putative Zn2+ binding site [ion binding]; other site 1302650007606 AsnC family; Region: AsnC_trans_reg; pfam01037 1302650007607 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1302650007608 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1302650007609 RNAase interaction site [polypeptide binding]; other site 1302650007610 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1302650007611 Cytochrome P450; Region: p450; cl12078 1302650007612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1302650007613 Coenzyme A binding pocket [chemical binding]; other site 1302650007614 Isochorismatase family; Region: Isochorismatase; pfam00857 1302650007615 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1302650007616 catalytic triad [active] 1302650007617 conserved cis-peptide bond; other site 1302650007618 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1302650007619 DinB family; Region: DinB; pfam05163 1302650007620 DinB superfamily; Region: DinB_2; pfam12867 1302650007621 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1302650007622 Nitronate monooxygenase; Region: NMO; pfam03060 1302650007623 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1302650007624 FMN binding site [chemical binding]; other site 1302650007625 substrate binding site [chemical binding]; other site 1302650007626 putative catalytic residue [active] 1302650007627 glutamate racemase; Region: glut_race; TIGR00067 1302650007628 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1302650007629 putative binding site; other site 1302650007630 putative dimer interface [polypeptide binding]; other site 1302650007631 YodA lipocalin-like domain; Region: YodA; pfam09223 1302650007632 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 1302650007633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650007634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650007635 DNA binding residues [nucleotide binding] 1302650007636 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302650007637 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302650007638 active site 1302650007639 catalytic tetrad [active] 1302650007640 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1302650007641 chitosan binding site [chemical binding]; other site 1302650007642 catalytic residues [active] 1302650007643 Mor transcription activator family; Region: Mor; cl02360 1302650007644 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1302650007645 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1302650007646 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1302650007647 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1302650007648 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1302650007649 Bacterial SH3 domain; Region: SH3_3; cl17532 1302650007650 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650007651 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1302650007652 active site 1302650007653 metal binding site [ion binding]; metal-binding site 1302650007654 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1302650007655 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1302650007656 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1302650007657 NAD binding site [chemical binding]; other site 1302650007658 catalytic Zn binding site [ion binding]; other site 1302650007659 structural Zn binding site [ion binding]; other site 1302650007660 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1302650007661 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1302650007662 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1302650007663 DNA binding residues [nucleotide binding] 1302650007664 putative dimer interface [polypeptide binding]; other site 1302650007665 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1302650007666 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1302650007667 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1302650007668 putative NAD(P) binding site [chemical binding]; other site 1302650007669 putative substrate binding site [chemical binding]; other site 1302650007670 catalytic Zn binding site [ion binding]; other site 1302650007671 structural Zn binding site [ion binding]; other site 1302650007672 dimer interface [polypeptide binding]; other site 1302650007673 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1302650007674 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1302650007675 proposed catalytic triad [active] 1302650007676 conserved cys residue [active] 1302650007677 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1302650007678 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1302650007679 substrate binding [chemical binding]; other site 1302650007680 active site 1302650007681 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1302650007682 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1302650007683 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1302650007684 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1302650007685 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1302650007686 active site 1302650007687 phosphorylation site [posttranslational modification] 1302650007688 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1302650007689 active pocket/dimerization site; other site 1302650007690 active site 1302650007691 phosphorylation site [posttranslational modification] 1302650007692 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1302650007693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650007694 Walker A motif; other site 1302650007695 ATP binding site [chemical binding]; other site 1302650007696 Walker B motif; other site 1302650007697 arginine finger; other site 1302650007698 Transcriptional antiterminator [Transcription]; Region: COG3933 1302650007699 PRD domain; Region: PRD; pfam00874 1302650007700 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1302650007701 active pocket/dimerization site; other site 1302650007702 active site 1302650007703 phosphorylation site [posttranslational modification] 1302650007704 PRD domain; Region: PRD; pfam00874 1302650007705 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1302650007706 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1302650007707 Predicted transcriptional regulators [Transcription]; Region: COG1378 1302650007708 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1302650007709 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1302650007710 C-terminal domain interface [polypeptide binding]; other site 1302650007711 sugar binding site [chemical binding]; other site 1302650007712 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1302650007713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650007714 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650007715 DNA binding residues [nucleotide binding] 1302650007716 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1302650007717 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1302650007718 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1302650007719 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1302650007720 catalytic triad [active] 1302650007721 catalytic triad [active] 1302650007722 oxyanion hole [active] 1302650007723 YrhK-like protein; Region: YrhK; pfam14145 1302650007724 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1302650007725 Cytochrome P450; Region: p450; pfam00067 1302650007726 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1302650007727 Flavodoxin; Region: Flavodoxin_1; pfam00258 1302650007728 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1302650007729 FAD binding pocket [chemical binding]; other site 1302650007730 FAD binding motif [chemical binding]; other site 1302650007731 catalytic residues [active] 1302650007732 NAD binding pocket [chemical binding]; other site 1302650007733 phosphate binding motif [ion binding]; other site 1302650007734 beta-alpha-beta structure motif; other site 1302650007735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650007736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650007737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650007738 S-adenosylmethionine binding site [chemical binding]; other site 1302650007739 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1302650007740 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1302650007741 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1302650007742 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1302650007743 catalytic loop [active] 1302650007744 iron binding site [ion binding]; other site 1302650007745 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1302650007746 4Fe-4S binding domain; Region: Fer4; pfam00037 1302650007747 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1302650007748 [4Fe-4S] binding site [ion binding]; other site 1302650007749 molybdopterin cofactor binding site; other site 1302650007750 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1302650007751 molybdopterin cofactor binding site; other site 1302650007752 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1302650007753 YrhC-like protein; Region: YrhC; pfam14143 1302650007754 cystathionine beta-lyase; Provisional; Region: PRK07671 1302650007755 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1302650007756 homodimer interface [polypeptide binding]; other site 1302650007757 substrate-cofactor binding pocket; other site 1302650007758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650007759 catalytic residue [active] 1302650007760 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1302650007761 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1302650007762 dimer interface [polypeptide binding]; other site 1302650007763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650007764 catalytic residue [active] 1302650007765 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1302650007766 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1302650007767 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1302650007768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650007769 S-adenosylmethionine binding site [chemical binding]; other site 1302650007770 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1302650007771 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1302650007772 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1302650007773 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302650007774 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302650007775 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1302650007776 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1302650007777 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1302650007778 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1302650007779 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1302650007780 ATP-binding site [chemical binding]; other site 1302650007781 Sugar specificity; other site 1302650007782 Pyrimidine base specificity; other site 1302650007783 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1302650007784 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1302650007785 Peptidase family U32; Region: Peptidase_U32; pfam01136 1302650007786 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1302650007787 Peptidase family U32; Region: Peptidase_U32; pfam01136 1302650007788 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1302650007789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650007790 S-adenosylmethionine binding site [chemical binding]; other site 1302650007791 conserved hypothetical protein, YceG family; Region: TIGR00247 1302650007792 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1302650007793 dimerization interface [polypeptide binding]; other site 1302650007794 hypothetical protein; Provisional; Region: PRK13678 1302650007795 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1302650007796 hypothetical protein; Provisional; Region: PRK05473 1302650007797 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1302650007798 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1302650007799 motif 1; other site 1302650007800 active site 1302650007801 motif 2; other site 1302650007802 motif 3; other site 1302650007803 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1302650007804 DHHA1 domain; Region: DHHA1; pfam02272 1302650007805 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1302650007806 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1302650007807 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302650007808 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1302650007809 Walker A/P-loop; other site 1302650007810 ATP binding site [chemical binding]; other site 1302650007811 Q-loop/lid; other site 1302650007812 ABC transporter signature motif; other site 1302650007813 Walker B; other site 1302650007814 D-loop; other site 1302650007815 H-loop/switch region; other site 1302650007816 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1302650007817 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302650007818 substrate binding pocket [chemical binding]; other site 1302650007819 membrane-bound complex binding site; other site 1302650007820 hinge residues; other site 1302650007821 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1302650007822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650007823 dimer interface [polypeptide binding]; other site 1302650007824 conserved gate region; other site 1302650007825 putative PBP binding loops; other site 1302650007826 ABC-ATPase subunit interface; other site 1302650007827 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1302650007828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650007829 dimer interface [polypeptide binding]; other site 1302650007830 ABC-ATPase subunit interface; other site 1302650007831 putative PBP binding loops; other site 1302650007832 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1302650007833 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1302650007834 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1302650007835 AAA domain; Region: AAA_30; pfam13604 1302650007836 Family description; Region: UvrD_C_2; pfam13538 1302650007837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650007838 binding surface 1302650007839 TPR motif; other site 1302650007840 TPR repeat; Region: TPR_11; pfam13414 1302650007841 TPR repeat; Region: TPR_11; pfam13414 1302650007842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650007843 binding surface 1302650007844 TPR motif; other site 1302650007845 TPR repeat; Region: TPR_11; pfam13414 1302650007846 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1302650007847 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1302650007848 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1302650007849 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1302650007850 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302650007851 catalytic residue [active] 1302650007852 Predicted transcriptional regulator [Transcription]; Region: COG1959 1302650007853 Transcriptional regulator; Region: Rrf2; pfam02082 1302650007854 recombination factor protein RarA; Reviewed; Region: PRK13342 1302650007855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650007856 Walker A motif; other site 1302650007857 ATP binding site [chemical binding]; other site 1302650007858 Walker B motif; other site 1302650007859 arginine finger; other site 1302650007860 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1302650007861 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1302650007862 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1302650007863 putative ATP binding site [chemical binding]; other site 1302650007864 putative substrate interface [chemical binding]; other site 1302650007865 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1302650007866 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1302650007867 dimer interface [polypeptide binding]; other site 1302650007868 anticodon binding site; other site 1302650007869 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1302650007870 homodimer interface [polypeptide binding]; other site 1302650007871 motif 1; other site 1302650007872 active site 1302650007873 motif 2; other site 1302650007874 GAD domain; Region: GAD; pfam02938 1302650007875 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1302650007876 motif 3; other site 1302650007877 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1302650007878 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1302650007879 dimer interface [polypeptide binding]; other site 1302650007880 motif 1; other site 1302650007881 active site 1302650007882 motif 2; other site 1302650007883 motif 3; other site 1302650007884 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1302650007885 anticodon binding site; other site 1302650007886 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1302650007887 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1302650007888 Bacterial SH3 domain; Region: SH3_3; pfam08239 1302650007889 Bacterial SH3 domain; Region: SH3_3; pfam08239 1302650007890 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1302650007891 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1302650007892 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1302650007893 active site 1302650007894 metal binding site [ion binding]; metal-binding site 1302650007895 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1302650007896 putative active site [active] 1302650007897 dimerization interface [polypeptide binding]; other site 1302650007898 putative tRNAtyr binding site [nucleotide binding]; other site 1302650007899 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1302650007900 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302650007901 Zn2+ binding site [ion binding]; other site 1302650007902 Mg2+ binding site [ion binding]; other site 1302650007903 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1302650007904 synthetase active site [active] 1302650007905 NTP binding site [chemical binding]; other site 1302650007906 metal binding site [ion binding]; metal-binding site 1302650007907 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1302650007908 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1302650007909 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650007910 active site 1302650007911 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1302650007912 DHH family; Region: DHH; pfam01368 1302650007913 DHHA1 domain; Region: DHHA1; pfam02272 1302650007914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1302650007915 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1302650007916 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1302650007917 TrkA-C domain; Region: TrkA_C; pfam02080 1302650007918 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1302650007919 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1302650007920 Protein export membrane protein; Region: SecD_SecF; pfam02355 1302650007921 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1302650007922 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1302650007923 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1302650007924 Predicted membrane protein [Function unknown]; Region: COG2323 1302650007925 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1302650007926 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1302650007927 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1302650007928 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1302650007929 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1302650007930 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1302650007931 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1302650007932 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1302650007933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650007934 Walker A motif; other site 1302650007935 ATP binding site [chemical binding]; other site 1302650007936 Walker B motif; other site 1302650007937 arginine finger; other site 1302650007938 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1302650007939 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1302650007940 RuvA N terminal domain; Region: RuvA_N; pfam01330 1302650007941 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1302650007942 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1302650007943 BofC C-terminal domain; Region: BofC_C; pfam08955 1302650007944 polyol permease family; Region: 2A0118; TIGR00897 1302650007945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650007946 putative substrate translocation pore; other site 1302650007947 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1302650007948 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1302650007949 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1302650007950 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1302650007951 active site 1302650007952 substrate binding site [chemical binding]; other site 1302650007953 ATP binding site [chemical binding]; other site 1302650007954 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1302650007955 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1302650007956 hypothetical protein; Validated; Region: PRK00110 1302650007957 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1302650007958 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650007959 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1302650007960 quinolinate synthetase complex, A subunit; Region: nadA; TIGR00550 1302650007961 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1302650007962 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1302650007963 dimerization interface [polypeptide binding]; other site 1302650007964 active site 1302650007965 L-aspartate oxidase; Provisional; Region: PRK08071 1302650007966 L-aspartate oxidase; Provisional; Region: PRK06175 1302650007967 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1302650007968 cysteine desulfurase; Provisional; Region: PRK02948 1302650007969 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1302650007970 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302650007971 catalytic residue [active] 1302650007972 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1302650007973 HTH domain; Region: HTH_11; pfam08279 1302650007974 3H domain; Region: 3H; pfam02829 1302650007975 prephenate dehydratase; Provisional; Region: PRK11898 1302650007976 Prephenate dehydratase; Region: PDT; pfam00800 1302650007977 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1302650007978 putative L-Phe binding site [chemical binding]; other site 1302650007979 hypothetical protein; Provisional; Region: PRK04435 1302650007980 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1302650007981 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1302650007982 GTP1/OBG; Region: GTP1_OBG; pfam01018 1302650007983 Obg GTPase; Region: Obg; cd01898 1302650007984 G1 box; other site 1302650007985 GTP/Mg2+ binding site [chemical binding]; other site 1302650007986 Switch I region; other site 1302650007987 G2 box; other site 1302650007988 G3 box; other site 1302650007989 Switch II region; other site 1302650007990 G4 box; other site 1302650007991 G5 box; other site 1302650007992 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1302650007993 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1302650007994 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1302650007995 hypothetical protein; Provisional; Region: PRK14553 1302650007996 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1302650007997 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1302650007998 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1302650007999 active site 1302650008000 Peptidase family M50; Region: Peptidase_M50; pfam02163 1302650008001 putative substrate binding region [chemical binding]; other site 1302650008002 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1302650008003 Peptidase family M23; Region: Peptidase_M23; pfam01551 1302650008004 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1302650008005 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1302650008006 Switch I; other site 1302650008007 Switch II; other site 1302650008008 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1302650008009 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1302650008010 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1302650008011 rod shape-determining protein MreC; Region: mreC; TIGR00219 1302650008012 rod shape-determining protein MreC; Region: MreC; pfam04085 1302650008013 rod shape-determining protein MreB; Provisional; Region: PRK13927 1302650008014 MreB and similar proteins; Region: MreB_like; cd10225 1302650008015 nucleotide binding site [chemical binding]; other site 1302650008016 Mg binding site [ion binding]; other site 1302650008017 putative protofilament interaction site [polypeptide binding]; other site 1302650008018 RodZ interaction site [polypeptide binding]; other site 1302650008019 hypothetical protein; Reviewed; Region: PRK00024 1302650008020 Helix-hairpin-helix motif; Region: HHH; pfam00633 1302650008021 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1302650008022 MPN+ (JAMM) motif; other site 1302650008023 Zinc-binding site [ion binding]; other site 1302650008024 Maf-like protein; Region: Maf; pfam02545 1302650008025 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1302650008026 active site 1302650008027 dimer interface [polypeptide binding]; other site 1302650008028 Sporulation related domain; Region: SPOR; pfam05036 1302650008029 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1302650008030 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1302650008031 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1302650008032 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1302650008033 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302650008034 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302650008035 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1302650008036 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1302650008037 active site 1302650008038 HIGH motif; other site 1302650008039 nucleotide binding site [chemical binding]; other site 1302650008040 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1302650008041 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1302650008042 active site 1302650008043 KMSKS motif; other site 1302650008044 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1302650008045 tRNA binding surface [nucleotide binding]; other site 1302650008046 anticodon binding site; other site 1302650008047 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1302650008048 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1302650008049 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1302650008050 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302650008051 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1302650008052 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1302650008053 inhibitor-cofactor binding pocket; inhibition site 1302650008054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650008055 catalytic residue [active] 1302650008056 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1302650008057 dimer interface [polypeptide binding]; other site 1302650008058 active site 1302650008059 Schiff base residues; other site 1302650008060 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1302650008061 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1302650008062 active site 1302650008063 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1302650008064 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1302650008065 domain interfaces; other site 1302650008066 active site 1302650008067 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1302650008068 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1302650008069 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1302650008070 tRNA; other site 1302650008071 putative tRNA binding site [nucleotide binding]; other site 1302650008072 putative NADP binding site [chemical binding]; other site 1302650008073 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1302650008074 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1302650008075 G1 box; other site 1302650008076 GTP/Mg2+ binding site [chemical binding]; other site 1302650008077 Switch I region; other site 1302650008078 G2 box; other site 1302650008079 G3 box; other site 1302650008080 Switch II region; other site 1302650008081 G4 box; other site 1302650008082 G5 box; other site 1302650008083 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1302650008084 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1302650008085 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1302650008086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650008087 Walker A motif; other site 1302650008088 ATP binding site [chemical binding]; other site 1302650008089 Walker B motif; other site 1302650008090 arginine finger; other site 1302650008091 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1302650008092 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1302650008093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650008094 Walker A motif; other site 1302650008095 ATP binding site [chemical binding]; other site 1302650008096 Walker B motif; other site 1302650008097 arginine finger; other site 1302650008098 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1302650008099 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1302650008100 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1302650008101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650008102 Walker A motif; other site 1302650008103 ATP binding site [chemical binding]; other site 1302650008104 Walker B motif; other site 1302650008105 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1302650008106 trigger factor; Provisional; Region: tig; PRK01490 1302650008107 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1302650008108 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1302650008109 TPR repeat; Region: TPR_11; pfam13414 1302650008110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650008111 binding surface 1302650008112 TPR motif; other site 1302650008113 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1302650008114 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1302650008115 substrate binding site [chemical binding]; other site 1302650008116 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1302650008117 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1302650008118 substrate binding site [chemical binding]; other site 1302650008119 ligand binding site [chemical binding]; other site 1302650008120 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1302650008121 tartrate dehydrogenase; Region: TTC; TIGR02089 1302650008122 2-isopropylmalate synthase; Validated; Region: PRK00915 1302650008123 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1302650008124 active site 1302650008125 catalytic residues [active] 1302650008126 metal binding site [ion binding]; metal-binding site 1302650008127 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1302650008128 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1302650008129 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1302650008130 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1302650008131 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1302650008132 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1302650008133 putative valine binding site [chemical binding]; other site 1302650008134 dimer interface [polypeptide binding]; other site 1302650008135 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1302650008136 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1302650008137 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1302650008138 PYR/PP interface [polypeptide binding]; other site 1302650008139 dimer interface [polypeptide binding]; other site 1302650008140 TPP binding site [chemical binding]; other site 1302650008141 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1302650008142 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1302650008143 TPP-binding site [chemical binding]; other site 1302650008144 dimer interface [polypeptide binding]; other site 1302650008145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1302650008146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650008147 Coenzyme A binding pocket [chemical binding]; other site 1302650008148 Heat induced stress protein YflT; Region: YflT; pfam11181 1302650008149 conserved domain; Region: TIGR02271 1302650008150 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1302650008151 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1302650008152 active site 1302650008153 metal binding site [ion binding]; metal-binding site 1302650008154 homotetramer interface [polypeptide binding]; other site 1302650008155 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1302650008156 active site 1302650008157 dimerization interface [polypeptide binding]; other site 1302650008158 ribonuclease PH; Reviewed; Region: rph; PRK00173 1302650008159 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1302650008160 hexamer interface [polypeptide binding]; other site 1302650008161 active site 1302650008162 Spore germination protein [General function prediction only]; Region: COG5401 1302650008163 Sporulation and spore germination; Region: Germane; pfam10646 1302650008164 Sporulation and spore germination; Region: Germane; pfam10646 1302650008165 glutamate racemase; Region: glut_race; TIGR00067 1302650008166 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650008167 MarR family; Region: MarR; pfam01047 1302650008168 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650008169 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650008170 DNA binding residues [nucleotide binding] 1302650008171 dimerization interface [polypeptide binding]; other site 1302650008172 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1302650008173 active site 1302650008174 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1302650008175 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1302650008176 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1302650008177 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1302650008178 L-aspartate oxidase; Provisional; Region: PRK06175 1302650008179 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1302650008180 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1302650008181 putative Iron-sulfur protein interface [polypeptide binding]; other site 1302650008182 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1302650008183 proximal heme binding site [chemical binding]; other site 1302650008184 distal heme binding site [chemical binding]; other site 1302650008185 putative dimer interface [polypeptide binding]; other site 1302650008186 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1302650008187 aspartate kinase; Reviewed; Region: PRK06635 1302650008188 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1302650008189 putative nucleotide binding site [chemical binding]; other site 1302650008190 putative catalytic residues [active] 1302650008191 putative Mg ion binding site [ion binding]; other site 1302650008192 putative aspartate binding site [chemical binding]; other site 1302650008193 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1302650008194 putative allosteric regulatory site; other site 1302650008195 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1302650008196 putative allosteric regulatory residue; other site 1302650008197 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1302650008198 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1302650008199 GIY-YIG motif/motif A; other site 1302650008200 active site 1302650008201 catalytic site [active] 1302650008202 putative DNA binding site [nucleotide binding]; other site 1302650008203 metal binding site [ion binding]; metal-binding site 1302650008204 UvrB/uvrC motif; Region: UVR; pfam02151 1302650008205 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1302650008206 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302650008207 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302650008208 catalytic residues [active] 1302650008209 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1302650008210 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1302650008211 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1302650008212 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1302650008213 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1302650008214 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1302650008215 Ligand binding site [chemical binding]; other site 1302650008216 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1302650008217 enoyl-CoA hydratase; Provisional; Region: PRK07658 1302650008218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1302650008219 substrate binding site [chemical binding]; other site 1302650008220 oxyanion hole (OAH) forming residues; other site 1302650008221 trimer interface [polypeptide binding]; other site 1302650008222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650008223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650008224 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1302650008225 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1302650008226 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1302650008227 acyl-activating enzyme (AAE) consensus motif; other site 1302650008228 putative AMP binding site [chemical binding]; other site 1302650008229 putative active site [active] 1302650008230 putative CoA binding site [chemical binding]; other site 1302650008231 Predicted membrane protein [Function unknown]; Region: COG3766 1302650008232 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1302650008233 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1302650008234 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1302650008235 MutS domain III; Region: MutS_III; pfam05192 1302650008236 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1302650008237 Walker A/P-loop; other site 1302650008238 ATP binding site [chemical binding]; other site 1302650008239 Q-loop/lid; other site 1302650008240 ABC transporter signature motif; other site 1302650008241 Walker B; other site 1302650008242 D-loop; other site 1302650008243 H-loop/switch region; other site 1302650008244 Smr domain; Region: Smr; pfam01713 1302650008245 hypothetical protein; Provisional; Region: PRK08609 1302650008246 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1302650008247 active site 1302650008248 primer binding site [nucleotide binding]; other site 1302650008249 NTP binding site [chemical binding]; other site 1302650008250 metal binding triad [ion binding]; metal-binding site 1302650008251 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1302650008252 active site 1302650008253 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1302650008254 Colicin V production protein; Region: Colicin_V; pfam02674 1302650008255 cell division protein ZapA; Provisional; Region: PRK14126 1302650008256 ribonuclease HIII; Provisional; Region: PRK00996 1302650008257 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1302650008258 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1302650008259 RNA/DNA hybrid binding site [nucleotide binding]; other site 1302650008260 active site 1302650008261 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1302650008262 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1302650008263 putative tRNA-binding site [nucleotide binding]; other site 1302650008264 B3/4 domain; Region: B3_4; pfam03483 1302650008265 tRNA synthetase B5 domain; Region: B5; smart00874 1302650008266 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1302650008267 dimer interface [polypeptide binding]; other site 1302650008268 motif 1; other site 1302650008269 motif 3; other site 1302650008270 motif 2; other site 1302650008271 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1302650008272 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1302650008273 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1302650008274 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1302650008275 dimer interface [polypeptide binding]; other site 1302650008276 motif 1; other site 1302650008277 active site 1302650008278 motif 2; other site 1302650008279 motif 3; other site 1302650008280 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1302650008281 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1302650008282 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1302650008283 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1302650008284 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1302650008285 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1302650008286 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1302650008287 FAD binding domain; Region: FAD_binding_4; pfam01565 1302650008288 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1302650008289 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1302650008290 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1302650008291 Cysteine-rich domain; Region: CCG; pfam02754 1302650008292 Cysteine-rich domain; Region: CCG; pfam02754 1302650008293 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1302650008294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650008295 active site 1302650008296 metal binding site [ion binding]; metal-binding site 1302650008297 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1302650008298 Carbon starvation protein CstA; Region: CstA; pfam02554 1302650008299 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1302650008300 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1302650008301 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1302650008302 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302650008303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650008304 putative PBP binding loops; other site 1302650008305 dimer interface [polypeptide binding]; other site 1302650008306 ABC-ATPase subunit interface; other site 1302650008307 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1302650008308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650008309 dimer interface [polypeptide binding]; other site 1302650008310 conserved gate region; other site 1302650008311 putative PBP binding loops; other site 1302650008312 ABC-ATPase subunit interface; other site 1302650008313 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1302650008314 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302650008315 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1302650008316 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1302650008317 active site 1302650008318 metal binding site [ion binding]; metal-binding site 1302650008319 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1302650008320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650008321 active site 1302650008322 motif I; other site 1302650008323 motif II; other site 1302650008324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650008325 motif II; other site 1302650008326 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1302650008327 L-ribulose-5-phosphate 4-epimerase; Region: araD; TIGR00760 1302650008328 intersubunit interface [polypeptide binding]; other site 1302650008329 active site 1302650008330 Zn2+ binding site [ion binding]; other site 1302650008331 L-ribulokinase; Region: L-ribulokinase; TIGR01234 1302650008332 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1302650008333 N- and C-terminal domain interface [polypeptide binding]; other site 1302650008334 active site 1302650008335 MgATP binding site [chemical binding]; other site 1302650008336 catalytic site [active] 1302650008337 metal binding site [ion binding]; metal-binding site 1302650008338 carbohydrate binding site [chemical binding]; other site 1302650008339 homodimer interface [polypeptide binding]; other site 1302650008340 L-arabinose isomerase; Provisional; Region: PRK02929 1302650008341 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1302650008342 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1302650008343 trimer interface [polypeptide binding]; other site 1302650008344 putative substrate binding site [chemical binding]; other site 1302650008345 putative metal binding site [ion binding]; other site 1302650008346 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1302650008347 substrate binding site [chemical binding]; other site 1302650008348 active site 1302650008349 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1302650008350 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1302650008351 oligomer interface [polypeptide binding]; other site 1302650008352 active site 1302650008353 metal binding site [ion binding]; metal-binding site 1302650008354 Predicted membrane protein [Function unknown]; Region: COG3326 1302650008355 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1302650008356 23S rRNA binding site [nucleotide binding]; other site 1302650008357 L21 binding site [polypeptide binding]; other site 1302650008358 L13 binding site [polypeptide binding]; other site 1302650008359 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1302650008360 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1302650008361 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1302650008362 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1302650008363 antiholin-like protein LrgB; Provisional; Region: PRK04288 1302650008364 LrgA family; Region: LrgA; cl00608 1302650008365 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1302650008366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650008367 active site 1302650008368 phosphorylation site [posttranslational modification] 1302650008369 intermolecular recognition site; other site 1302650008370 dimerization interface [polypeptide binding]; other site 1302650008371 LytTr DNA-binding domain; Region: LytTR; pfam04397 1302650008372 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1302650008373 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1302650008374 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1302650008375 Histidine kinase; Region: His_kinase; pfam06580 1302650008376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650008377 ATP binding site [chemical binding]; other site 1302650008378 Mg2+ binding site [ion binding]; other site 1302650008379 G-X-G motif; other site 1302650008380 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1302650008381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650008382 motif II; other site 1302650008383 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1302650008384 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1302650008385 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1302650008386 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1302650008387 active site 1302650008388 dimer interface [polypeptide binding]; other site 1302650008389 motif 1; other site 1302650008390 motif 2; other site 1302650008391 motif 3; other site 1302650008392 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1302650008393 anticodon binding site; other site 1302650008394 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 1302650008395 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1302650008396 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1302650008397 primosomal protein DnaI; Reviewed; Region: PRK08939 1302650008398 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1302650008399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650008400 Walker A motif; other site 1302650008401 ATP binding site [chemical binding]; other site 1302650008402 Walker B motif; other site 1302650008403 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1302650008404 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1302650008405 transcriptional regulator NrdR; Region: TIGR00244 1302650008406 ATP cone domain; Region: ATP-cone; pfam03477 1302650008407 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1302650008408 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1302650008409 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1302650008410 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1302650008411 Predicted transcriptional regulators [Transcription]; Region: COG1733 1302650008412 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1302650008413 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1302650008414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650008415 putative substrate translocation pore; other site 1302650008416 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302650008417 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302650008418 active site 1302650008419 catalytic tetrad [active] 1302650008420 dephospho-CoA kinase; Region: TIGR00152 1302650008421 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1302650008422 CoA-binding site [chemical binding]; other site 1302650008423 ATP-binding [chemical binding]; other site 1302650008424 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1302650008425 Domain of unknown function DUF; Region: DUF204; pfam02659 1302650008426 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1302650008427 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1302650008428 DNA binding site [nucleotide binding] 1302650008429 catalytic residue [active] 1302650008430 H2TH interface [polypeptide binding]; other site 1302650008431 putative catalytic residues [active] 1302650008432 turnover-facilitating residue; other site 1302650008433 intercalation triad [nucleotide binding]; other site 1302650008434 8OG recognition residue [nucleotide binding]; other site 1302650008435 putative reading head residues; other site 1302650008436 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1302650008437 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1302650008438 DNA polymerase I; Provisional; Region: PRK05755 1302650008439 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1302650008440 active site 1302650008441 metal binding site 1 [ion binding]; metal-binding site 1302650008442 putative 5' ssDNA interaction site; other site 1302650008443 metal binding site 3; metal-binding site 1302650008444 metal binding site 2 [ion binding]; metal-binding site 1302650008445 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1302650008446 putative DNA binding site [nucleotide binding]; other site 1302650008447 putative metal binding site [ion binding]; other site 1302650008448 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1302650008449 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1302650008450 active site 1302650008451 DNA binding site [nucleotide binding] 1302650008452 catalytic site [active] 1302650008453 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1302650008454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650008455 putative active site [active] 1302650008456 heme pocket [chemical binding]; other site 1302650008457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650008458 dimer interface [polypeptide binding]; other site 1302650008459 phosphorylation site [posttranslational modification] 1302650008460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650008461 ATP binding site [chemical binding]; other site 1302650008462 Mg2+ binding site [ion binding]; other site 1302650008463 G-X-G motif; other site 1302650008464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650008465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650008466 active site 1302650008467 phosphorylation site [posttranslational modification] 1302650008468 intermolecular recognition site; other site 1302650008469 dimerization interface [polypeptide binding]; other site 1302650008470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650008471 DNA binding site [nucleotide binding] 1302650008472 malate dehydrogenase; Reviewed; Region: PRK06223 1302650008473 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1302650008474 NAD(P) binding site [chemical binding]; other site 1302650008475 dimer interface [polypeptide binding]; other site 1302650008476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302650008477 substrate binding site [chemical binding]; other site 1302650008478 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1302650008479 isocitrate dehydrogenase; Validated; Region: PRK07362 1302650008480 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1302650008481 dimer interface [polypeptide binding]; other site 1302650008482 Citrate synthase; Region: Citrate_synt; pfam00285 1302650008483 active site 1302650008484 citrylCoA binding site [chemical binding]; other site 1302650008485 oxalacetate/citrate binding site [chemical binding]; other site 1302650008486 coenzyme A binding site [chemical binding]; other site 1302650008487 catalytic triad [active] 1302650008488 Predicted membrane protein [Function unknown]; Region: COG2707 1302650008489 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1302650008490 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1302650008491 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1302650008492 pyruvate kinase; Provisional; Region: PRK06354 1302650008493 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1302650008494 domain interfaces; other site 1302650008495 active site 1302650008496 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1302650008497 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1302650008498 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1302650008499 active site 1302650008500 ADP/pyrophosphate binding site [chemical binding]; other site 1302650008501 dimerization interface [polypeptide binding]; other site 1302650008502 allosteric effector site; other site 1302650008503 fructose-1,6-bisphosphate binding site; other site 1302650008504 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1302650008505 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1302650008506 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1302650008507 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1302650008508 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1302650008509 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1302650008510 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1302650008511 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1302650008512 putative NAD(P) binding site [chemical binding]; other site 1302650008513 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1302650008514 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1302650008515 active site 1302650008516 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1302650008517 generic binding surface I; other site 1302650008518 generic binding surface II; other site 1302650008519 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1302650008520 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1302650008521 DHH family; Region: DHH; pfam01368 1302650008522 DHHA1 domain; Region: DHHA1; pfam02272 1302650008523 YtpI-like protein; Region: YtpI; pfam14007 1302650008524 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1302650008525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650008526 DNA-binding site [nucleotide binding]; DNA binding site 1302650008527 DRTGG domain; Region: DRTGG; pfam07085 1302650008528 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1302650008529 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1302650008530 active site 2 [active] 1302650008531 active site 1 [active] 1302650008532 Predicted permeases [General function prediction only]; Region: COG0730 1302650008533 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1302650008534 amidohydrolase; Region: amidohydrolases; TIGR01891 1302650008535 metal binding site [ion binding]; metal-binding site 1302650008536 dimer interface [polypeptide binding]; other site 1302650008537 Riboflavin kinase; Region: Flavokinase; pfam01687 1302650008538 Riboflavin kinase; Region: Flavokinase; cl03312 1302650008539 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1302650008540 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1302650008541 active site 1302650008542 non-prolyl cis peptide bond; other site 1302650008543 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1302650008544 catalytic residues [active] 1302650008545 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1302650008546 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1302650008547 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1302650008548 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302650008549 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1302650008550 Walker A/P-loop; other site 1302650008551 ATP binding site [chemical binding]; other site 1302650008552 Q-loop/lid; other site 1302650008553 ABC transporter signature motif; other site 1302650008554 Walker B; other site 1302650008555 D-loop; other site 1302650008556 H-loop/switch region; other site 1302650008557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650008558 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1302650008559 dimer interface [polypeptide binding]; other site 1302650008560 conserved gate region; other site 1302650008561 putative PBP binding loops; other site 1302650008562 ABC-ATPase subunit interface; other site 1302650008563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650008564 dimer interface [polypeptide binding]; other site 1302650008565 conserved gate region; other site 1302650008566 putative PBP binding loops; other site 1302650008567 ABC-ATPase subunit interface; other site 1302650008568 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302650008569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302650008570 substrate binding pocket [chemical binding]; other site 1302650008571 membrane-bound complex binding site; other site 1302650008572 hinge residues; other site 1302650008573 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1302650008574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302650008575 substrate binding pocket [chemical binding]; other site 1302650008576 membrane-bound complex binding site; other site 1302650008577 hinge residues; other site 1302650008578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1302650008579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650008580 Coenzyme A binding pocket [chemical binding]; other site 1302650008581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650008582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650008583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302650008584 dimerization interface [polypeptide binding]; other site 1302650008585 metal-dependent hydrolase; Provisional; Region: PRK00685 1302650008586 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1302650008587 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1302650008588 classical (c) SDRs; Region: SDR_c; cd05233 1302650008589 NAD(P) binding site [chemical binding]; other site 1302650008590 active site 1302650008591 argininosuccinate lyase; Provisional; Region: PRK00855 1302650008592 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1302650008593 active sites [active] 1302650008594 tetramer interface [polypeptide binding]; other site 1302650008595 argininosuccinate synthase; Provisional; Region: PRK13820 1302650008596 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1302650008597 ANP binding site [chemical binding]; other site 1302650008598 Substrate Binding Site II [chemical binding]; other site 1302650008599 Substrate Binding Site I [chemical binding]; other site 1302650008600 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1302650008601 MPT binding site; other site 1302650008602 trimer interface [polypeptide binding]; other site 1302650008603 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1302650008604 propionate/acetate kinase; Provisional; Region: PRK12379 1302650008605 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1302650008606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650008607 S-adenosylmethionine binding site [chemical binding]; other site 1302650008608 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1302650008609 dimer interface [polypeptide binding]; other site 1302650008610 catalytic triad [active] 1302650008611 peroxidatic and resolving cysteines [active] 1302650008612 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1302650008613 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1302650008614 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1302650008615 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1302650008616 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1302650008617 tandem repeat interface [polypeptide binding]; other site 1302650008618 oligomer interface [polypeptide binding]; other site 1302650008619 active site residues [active] 1302650008620 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1302650008621 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1302650008622 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1302650008623 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1302650008624 active site 1302650008625 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1302650008626 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1302650008627 active site 1302650008628 acyl-activating enzyme (AAE) consensus motif; other site 1302650008629 putative CoA binding site [chemical binding]; other site 1302650008630 AMP binding site [chemical binding]; other site 1302650008631 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1302650008632 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1302650008633 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1302650008634 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1302650008635 Ligand Binding Site [chemical binding]; other site 1302650008636 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1302650008637 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1302650008638 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302650008639 catalytic residue [active] 1302650008640 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1302650008641 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1302650008642 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1302650008643 oligomer interface [polypeptide binding]; other site 1302650008644 TMPIT-like protein; Region: TMPIT; pfam07851 1302650008645 histidinol-phosphatase; Reviewed; Region: PRK08123 1302650008646 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1302650008647 active site 1302650008648 dimer interface [polypeptide binding]; other site 1302650008649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650008650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650008651 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1302650008652 GAF domain; Region: GAF_2; pfam13185 1302650008653 GAF domain; Region: GAF; cl17456 1302650008654 GAF domain; Region: GAF; cl17456 1302650008655 GAF domain; Region: GAF_2; pfam13185 1302650008656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1302650008657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1302650008658 metal binding site [ion binding]; metal-binding site 1302650008659 active site 1302650008660 I-site; other site 1302650008661 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1302650008662 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1302650008663 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650008664 RNA binding surface [nucleotide binding]; other site 1302650008665 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1302650008666 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1302650008667 active site 1302650008668 HIGH motif; other site 1302650008669 dimer interface [polypeptide binding]; other site 1302650008670 KMSKS motif; other site 1302650008671 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650008672 RNA binding surface [nucleotide binding]; other site 1302650008673 acetyl-CoA synthetase; Provisional; Region: PRK04319 1302650008674 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1302650008675 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1302650008676 active site 1302650008677 acyl-activating enzyme (AAE) consensus motif; other site 1302650008678 putative CoA binding site [chemical binding]; other site 1302650008679 AMP binding site [chemical binding]; other site 1302650008680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650008681 Coenzyme A binding pocket [chemical binding]; other site 1302650008682 FOG: CBS domain [General function prediction only]; Region: COG0517 1302650008683 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1302650008684 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1302650008685 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1302650008686 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1302650008687 active site 1302650008688 Zn binding site [ion binding]; other site 1302650008689 flagellar motor protein MotS; Reviewed; Region: PRK06925 1302650008690 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1302650008691 ligand binding site [chemical binding]; other site 1302650008692 flagellar motor protein MotP; Reviewed; Region: PRK06926 1302650008693 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1302650008694 catabolite control protein A; Region: ccpA; TIGR01481 1302650008695 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650008696 DNA binding site [nucleotide binding] 1302650008697 domain linker motif; other site 1302650008698 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1302650008699 dimerization interface [polypeptide binding]; other site 1302650008700 effector binding site; other site 1302650008701 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1302650008702 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 1302650008703 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1302650008704 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302650008705 catalytic residues [active] 1302650008706 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1302650008707 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1302650008708 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1302650008709 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1302650008710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302650008711 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302650008712 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1302650008713 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302650008714 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1302650008715 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1302650008716 putative tRNA-binding site [nucleotide binding]; other site 1302650008717 hypothetical protein; Provisional; Region: PRK13668 1302650008718 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302650008719 catalytic residues [active] 1302650008720 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1302650008721 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1302650008722 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1302650008723 oligomer interface [polypeptide binding]; other site 1302650008724 active site 1302650008725 metal binding site [ion binding]; metal-binding site 1302650008726 Predicted small secreted protein [Function unknown]; Region: COG5584 1302650008727 malate dehydrogenase; Provisional; Region: PRK13529 1302650008728 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1302650008729 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1302650008730 NAD(P) binding site [chemical binding]; other site 1302650008731 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1302650008732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650008733 S-adenosylmethionine binding site [chemical binding]; other site 1302650008734 YtzH-like protein; Region: YtzH; pfam14165 1302650008735 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1302650008736 active site 1302650008737 ATP binding site [chemical binding]; other site 1302650008738 Phosphotransferase enzyme family; Region: APH; pfam01636 1302650008739 substrate binding site [chemical binding]; other site 1302650008740 pullulanase, type I; Region: pulA_typeI; TIGR02104 1302650008741 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1302650008742 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1302650008743 Ca binding site [ion binding]; other site 1302650008744 active site 1302650008745 catalytic site [active] 1302650008746 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1302650008747 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1302650008748 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1302650008749 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1302650008750 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1302650008751 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1302650008752 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1302650008753 dimer interface [polypeptide binding]; other site 1302650008754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650008755 catalytic residue [active] 1302650008756 dipeptidase PepV; Reviewed; Region: PRK07318 1302650008757 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1302650008758 active site 1302650008759 metal binding site [ion binding]; metal-binding site 1302650008760 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1302650008761 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1302650008762 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1302650008763 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302650008764 Walker A/P-loop; other site 1302650008765 ATP binding site [chemical binding]; other site 1302650008766 Q-loop/lid; other site 1302650008767 ABC transporter signature motif; other site 1302650008768 Walker B; other site 1302650008769 D-loop; other site 1302650008770 H-loop/switch region; other site 1302650008771 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1302650008772 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1302650008773 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1302650008774 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650008775 RNA binding surface [nucleotide binding]; other site 1302650008776 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1302650008777 active site 1302650008778 uracil binding [chemical binding]; other site 1302650008779 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1302650008780 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1302650008781 Predicted flavoproteins [General function prediction only]; Region: COG2081 1302650008782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1302650008783 BCCT family transporter; Region: BCCT; pfam02028 1302650008784 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1302650008785 Predicted integral membrane protein [Function unknown]; Region: COG5578 1302650008786 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1302650008787 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1302650008788 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1302650008789 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1302650008790 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1302650008791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650008792 dimer interface [polypeptide binding]; other site 1302650008793 conserved gate region; other site 1302650008794 ABC-ATPase subunit interface; other site 1302650008795 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1302650008796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650008797 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302650008798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302650008799 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1302650008800 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302650008801 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302650008802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650008803 dimer interface [polypeptide binding]; other site 1302650008804 conserved gate region; other site 1302650008805 putative PBP binding loops; other site 1302650008806 ABC-ATPase subunit interface; other site 1302650008807 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1302650008808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1302650008809 NAD(P) binding site [chemical binding]; other site 1302650008810 active site 1302650008811 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1302650008812 Cytochrome P450; Region: p450; cl12078 1302650008813 biotin synthase; Validated; Region: PRK06256 1302650008814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650008815 FeS/SAM binding site; other site 1302650008816 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1302650008817 AAA domain; Region: AAA_26; pfam13500 1302650008818 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1302650008819 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1302650008820 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1302650008821 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1302650008822 substrate-cofactor binding pocket; other site 1302650008823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650008824 catalytic residue [active] 1302650008825 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1302650008826 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1302650008827 inhibitor-cofactor binding pocket; inhibition site 1302650008828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650008829 catalytic residue [active] 1302650008830 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1302650008831 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1302650008832 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1302650008833 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650008834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650008835 DNA binding site [nucleotide binding] 1302650008836 domain linker motif; other site 1302650008837 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1302650008838 putative ligand binding site [chemical binding]; other site 1302650008839 putative dimerization interface [polypeptide binding]; other site 1302650008840 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302650008841 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1302650008842 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1302650008843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650008844 dimer interface [polypeptide binding]; other site 1302650008845 conserved gate region; other site 1302650008846 putative PBP binding loops; other site 1302650008847 ABC-ATPase subunit interface; other site 1302650008848 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302650008849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650008850 dimer interface [polypeptide binding]; other site 1302650008851 conserved gate region; other site 1302650008852 putative PBP binding loops; other site 1302650008853 ABC-ATPase subunit interface; other site 1302650008854 alpha-galactosidase; Provisional; Region: PRK15076 1302650008855 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1302650008856 NAD binding site [chemical binding]; other site 1302650008857 sugar binding site [chemical binding]; other site 1302650008858 divalent metal binding site [ion binding]; other site 1302650008859 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302650008860 dimer interface [polypeptide binding]; other site 1302650008861 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1302650008862 active site residue [active] 1302650008863 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1302650008864 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1302650008865 HIGH motif; other site 1302650008866 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1302650008867 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1302650008868 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1302650008869 active site 1302650008870 KMSKS motif; other site 1302650008871 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1302650008872 tRNA binding surface [nucleotide binding]; other site 1302650008873 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1302650008874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650008875 PAS domain; Region: PAS_9; pfam13426 1302650008876 putative active site [active] 1302650008877 heme pocket [chemical binding]; other site 1302650008878 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1302650008879 potential frameshift: common BLAST hit: gi|449095477|ref|YP_007427968.1| putative efflux transporter 1302650008880 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1302650008881 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1302650008882 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302650008883 FtsX-like permease family; Region: FtsX; pfam02687 1302650008884 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302650008885 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302650008886 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302650008887 Walker A/P-loop; other site 1302650008888 ATP binding site [chemical binding]; other site 1302650008889 Q-loop/lid; other site 1302650008890 ABC transporter signature motif; other site 1302650008891 Walker B; other site 1302650008892 D-loop; other site 1302650008893 H-loop/switch region; other site 1302650008894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650008895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650008896 ATP binding site [chemical binding]; other site 1302650008897 Mg2+ binding site [ion binding]; other site 1302650008898 G-X-G motif; other site 1302650008899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650008900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650008901 active site 1302650008902 phosphorylation site [posttranslational modification] 1302650008903 intermolecular recognition site; other site 1302650008904 dimerization interface [polypeptide binding]; other site 1302650008905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650008906 DNA binding site [nucleotide binding] 1302650008907 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1302650008908 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302650008909 FtsX-like permease family; Region: FtsX; pfam02687 1302650008910 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302650008911 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302650008912 Walker A/P-loop; other site 1302650008913 ATP binding site [chemical binding]; other site 1302650008914 Q-loop/lid; other site 1302650008915 ABC transporter signature motif; other site 1302650008916 Walker B; other site 1302650008917 D-loop; other site 1302650008918 H-loop/switch region; other site 1302650008919 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1302650008920 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1302650008921 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1302650008922 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302650008923 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302650008924 Walker A/P-loop; other site 1302650008925 ATP binding site [chemical binding]; other site 1302650008926 Q-loop/lid; other site 1302650008927 ABC transporter signature motif; other site 1302650008928 Walker B; other site 1302650008929 D-loop; other site 1302650008930 H-loop/switch region; other site 1302650008931 Predicted transcriptional regulators [Transcription]; Region: COG1725 1302650008932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650008933 DNA-binding site [nucleotide binding]; DNA binding site 1302650008934 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1302650008935 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1302650008936 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1302650008937 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1302650008938 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1302650008939 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1302650008940 PGAP1-like protein; Region: PGAP1; pfam07819 1302650008941 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1302650008942 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1302650008943 trimer interface [polypeptide binding]; other site 1302650008944 putative metal binding site [ion binding]; other site 1302650008945 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1302650008946 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1302650008947 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1302650008948 active site 1302650008949 dimer interface [polypeptide binding]; other site 1302650008950 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1302650008951 Ligand Binding Site [chemical binding]; other site 1302650008952 Molecular Tunnel; other site 1302650008953 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1302650008954 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1302650008955 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1302650008956 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1302650008957 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1302650008958 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1302650008959 active site 1302650008960 substrate-binding site [chemical binding]; other site 1302650008961 metal-binding site [ion binding] 1302650008962 ATP binding site [chemical binding]; other site 1302650008963 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1302650008964 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1302650008965 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1302650008966 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1302650008967 NMT1-like family; Region: NMT1_2; pfam13379 1302650008968 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1302650008969 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1302650008970 Walker A/P-loop; other site 1302650008971 ATP binding site [chemical binding]; other site 1302650008972 Q-loop/lid; other site 1302650008973 ABC transporter signature motif; other site 1302650008974 Walker B; other site 1302650008975 D-loop; other site 1302650008976 H-loop/switch region; other site 1302650008977 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1302650008978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650008979 dimer interface [polypeptide binding]; other site 1302650008980 conserved gate region; other site 1302650008981 putative PBP binding loops; other site 1302650008982 ABC-ATPase subunit interface; other site 1302650008983 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1302650008984 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1302650008985 nudix motif; other site 1302650008986 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1302650008987 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1302650008988 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1302650008989 dimerization interface [polypeptide binding]; other site 1302650008990 DPS ferroxidase diiron center [ion binding]; other site 1302650008991 ion pore; other site 1302650008992 YtkA-like; Region: YtkA; pfam13115 1302650008993 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 1302650008994 Haemolytic domain; Region: Haemolytic; pfam01809 1302650008995 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1302650008996 active site clefts [active] 1302650008997 zinc binding site [ion binding]; other site 1302650008998 dimer interface [polypeptide binding]; other site 1302650008999 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1302650009000 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1302650009001 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1302650009002 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1302650009003 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1302650009004 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650009005 ABC-ATPase subunit interface; other site 1302650009006 dimer interface [polypeptide binding]; other site 1302650009007 putative PBP binding regions; other site 1302650009008 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1302650009009 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650009010 ABC-ATPase subunit interface; other site 1302650009011 dimer interface [polypeptide binding]; other site 1302650009012 putative PBP binding regions; other site 1302650009013 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1302650009014 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1302650009015 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1302650009016 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1302650009017 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1302650009018 metal binding site [ion binding]; metal-binding site 1302650009019 intersubunit interface [polypeptide binding]; other site 1302650009020 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1302650009021 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1302650009022 active site 1302650009023 octamer interface [polypeptide binding]; other site 1302650009024 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1302650009025 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1302650009026 acyl-activating enzyme (AAE) consensus motif; other site 1302650009027 putative AMP binding site [chemical binding]; other site 1302650009028 putative active site [active] 1302650009029 putative CoA binding site [chemical binding]; other site 1302650009030 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1302650009031 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1302650009032 substrate binding site [chemical binding]; other site 1302650009033 oxyanion hole (OAH) forming residues; other site 1302650009034 trimer interface [polypeptide binding]; other site 1302650009035 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1302650009036 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1302650009037 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1302650009038 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1302650009039 dimer interface [polypeptide binding]; other site 1302650009040 tetramer interface [polypeptide binding]; other site 1302650009041 PYR/PP interface [polypeptide binding]; other site 1302650009042 TPP binding site [chemical binding]; other site 1302650009043 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1302650009044 TPP-binding site; other site 1302650009045 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1302650009046 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1302650009047 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1302650009048 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1302650009049 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1302650009050 active site 1302650009051 tetramer interface; other site 1302650009052 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1302650009053 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1302650009054 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1302650009055 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1302650009056 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1302650009057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1302650009058 NAD(P) binding site [chemical binding]; other site 1302650009059 active site 1302650009060 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302650009061 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1302650009062 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1302650009063 spore coat protein YutH; Region: spore_yutH; TIGR02905 1302650009064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302650009065 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1302650009066 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1302650009067 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1302650009068 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1302650009069 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1302650009070 homodimer interface [polypeptide binding]; other site 1302650009071 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1302650009072 active site pocket [active] 1302650009073 glycogen synthase; Provisional; Region: glgA; PRK00654 1302650009074 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1302650009075 ADP-binding pocket [chemical binding]; other site 1302650009076 homodimer interface [polypeptide binding]; other site 1302650009077 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1302650009078 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1302650009079 ligand binding site; other site 1302650009080 oligomer interface; other site 1302650009081 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1302650009082 dimer interface [polypeptide binding]; other site 1302650009083 N-terminal domain interface [polypeptide binding]; other site 1302650009084 sulfate 1 binding site; other site 1302650009085 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1302650009086 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1302650009087 ligand binding site; other site 1302650009088 oligomer interface; other site 1302650009089 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1302650009090 dimer interface [polypeptide binding]; other site 1302650009091 N-terminal domain interface [polypeptide binding]; other site 1302650009092 sulfate 1 binding site; other site 1302650009093 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 1302650009094 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1302650009095 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1302650009096 active site 1302650009097 catalytic site [active] 1302650009098 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1302650009099 potential protein location (hypothetical protein I653_14865 [Bacillus subtilis subsp. subtilis str. BAB-1]) that overlaps RNA (tRNA-A) 1302650009100 potential protein location (hypothetical protein I653_14865 [Bacillus subtilis subsp. subtilis str. BAB-1]) that overlaps RNA (tRNA-M) 1302650009101 potential protein location (hypothetical protein I653_14865 [Bacillus subtilis subsp. subtilis str. BAB-1]) that overlaps RNA (tRNA-P) 1302650009102 Predicted membrane protein [Function unknown]; Region: COG3859 1302650009103 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1302650009104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1302650009105 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1302650009106 DinB superfamily; Region: DinB_2; pfam12867 1302650009107 MOSC domain; Region: MOSC; pfam03473 1302650009108 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1302650009109 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1302650009110 active site 1302650009111 NAD binding site [chemical binding]; other site 1302650009112 metal binding site [ion binding]; metal-binding site 1302650009113 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1302650009114 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1302650009115 tetramerization interface [polypeptide binding]; other site 1302650009116 NAD(P) binding site [chemical binding]; other site 1302650009117 catalytic residues [active] 1302650009118 Predicted transcriptional regulators [Transcription]; Region: COG1510 1302650009119 MarR family; Region: MarR_2; pfam12802 1302650009120 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1302650009121 TrkA-N domain; Region: TrkA_N; pfam02254 1302650009122 TrkA-C domain; Region: TrkA_C; pfam02080 1302650009123 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1302650009124 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1302650009125 Predicted membrane protein [Function unknown]; Region: COG4682 1302650009126 yiaA/B two helix domain; Region: YiaAB; pfam05360 1302650009127 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1302650009128 SH3-like domain; Region: SH3_8; pfam13457 1302650009129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650009130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650009131 putative substrate translocation pore; other site 1302650009132 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1302650009133 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1302650009134 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1302650009135 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1302650009136 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1302650009137 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1302650009138 L-rhamnose isomerase (RhaA); Region: RhaA; pfam06134 1302650009139 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1302650009140 Domain of unknown function (DUF718); Region: DUF718; cl01281 1302650009141 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1302650009142 N- and C-terminal domain interface [polypeptide binding]; other site 1302650009143 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1302650009144 active site 1302650009145 putative catalytic site [active] 1302650009146 metal binding site [ion binding]; metal-binding site 1302650009147 ATP binding site [chemical binding]; other site 1302650009148 carbohydrate binding site [chemical binding]; other site 1302650009149 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1302650009150 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1302650009151 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1302650009152 short chain dehydrogenase; Validated; Region: PRK08324 1302650009153 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1302650009154 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1302650009155 putative NAD(P) binding site [chemical binding]; other site 1302650009156 active site 1302650009157 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1302650009158 Cache domain; Region: Cache_1; pfam02743 1302650009159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650009160 dimerization interface [polypeptide binding]; other site 1302650009161 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1302650009162 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650009163 dimer interface [polypeptide binding]; other site 1302650009164 putative CheW interface [polypeptide binding]; other site 1302650009165 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650009166 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1302650009167 Cache domain; Region: Cache_1; pfam02743 1302650009168 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650009169 dimerization interface [polypeptide binding]; other site 1302650009170 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650009171 dimer interface [polypeptide binding]; other site 1302650009172 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1302650009173 putative CheW interface [polypeptide binding]; other site 1302650009174 Tar ligand binding domain homologue; Region: TarH; pfam02203 1302650009175 Cache domain; Region: Cache_1; pfam02743 1302650009176 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1302650009177 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650009178 dimerization interface [polypeptide binding]; other site 1302650009179 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650009180 dimer interface [polypeptide binding]; other site 1302650009181 putative CheW interface [polypeptide binding]; other site 1302650009182 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1302650009183 Cache domain; Region: Cache_1; pfam02743 1302650009184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650009185 dimerization interface [polypeptide binding]; other site 1302650009186 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1302650009187 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650009188 dimer interface [polypeptide binding]; other site 1302650009189 putative CheW interface [polypeptide binding]; other site 1302650009190 transglutaminase; Provisional; Region: tgl; PRK03187 1302650009191 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1302650009192 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1302650009193 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1302650009194 Ca binding site [ion binding]; other site 1302650009195 active site 1302650009196 catalytic site [active] 1302650009197 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1302650009198 Domain of unknown function DUF21; Region: DUF21; pfam01595 1302650009199 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1302650009200 Transporter associated domain; Region: CorC_HlyC; smart01091 1302650009201 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1302650009202 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1302650009203 Ion channel; Region: Ion_trans_2; pfam07885 1302650009204 TrkA-N domain; Region: TrkA_N; pfam02254 1302650009205 YugN-like family; Region: YugN; pfam08868 1302650009206 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1302650009207 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1302650009208 active site 1302650009209 dimer interface [polypeptide binding]; other site 1302650009210 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1302650009211 dimer interface [polypeptide binding]; other site 1302650009212 active site 1302650009213 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1302650009214 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1302650009215 dimer interface [polypeptide binding]; other site 1302650009216 active site 1302650009217 metal binding site [ion binding]; metal-binding site 1302650009218 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1302650009219 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1302650009220 dimer interface [polypeptide binding]; other site 1302650009221 active site 1302650009222 metal binding site [ion binding]; metal-binding site 1302650009223 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1302650009224 general stress protein 13; Validated; Region: PRK08059 1302650009225 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1302650009226 RNA binding site [nucleotide binding]; other site 1302650009227 hypothetical protein; Validated; Region: PRK07682 1302650009228 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650009229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650009230 homodimer interface [polypeptide binding]; other site 1302650009231 catalytic residue [active] 1302650009232 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1302650009233 AsnC family; Region: AsnC_trans_reg; pfam01037 1302650009234 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650009235 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1302650009236 nucleophilic elbow; other site 1302650009237 catalytic triad; other site 1302650009238 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1302650009239 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1302650009240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650009241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650009242 homodimer interface [polypeptide binding]; other site 1302650009243 catalytic residue [active] 1302650009244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650009245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650009246 dimer interface [polypeptide binding]; other site 1302650009247 phosphorylation site [posttranslational modification] 1302650009248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650009249 ATP binding site [chemical binding]; other site 1302650009250 Mg2+ binding site [ion binding]; other site 1302650009251 G-X-G motif; other site 1302650009252 Kinase associated protein B; Region: KapB; pfam08810 1302650009253 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1302650009254 active site 1302650009255 catalytic site [active] 1302650009256 substrate binding site [chemical binding]; other site 1302650009257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650009258 putative substrate translocation pore; other site 1302650009259 Transglycosylase; Region: Transgly; pfam00912 1302650009260 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1302650009261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1302650009262 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1302650009263 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1302650009264 PAS domain; Region: PAS; smart00091 1302650009265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650009266 ATP binding site [chemical binding]; other site 1302650009267 G-X-G motif; other site 1302650009268 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1302650009269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650009270 active site 1302650009271 phosphorylation site [posttranslational modification] 1302650009272 intermolecular recognition site; other site 1302650009273 dimerization interface [polypeptide binding]; other site 1302650009274 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1302650009275 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1302650009276 ligand binding site [chemical binding]; other site 1302650009277 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1302650009278 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1302650009279 Walker A/P-loop; other site 1302650009280 ATP binding site [chemical binding]; other site 1302650009281 Q-loop/lid; other site 1302650009282 ABC transporter signature motif; other site 1302650009283 Walker B; other site 1302650009284 D-loop; other site 1302650009285 H-loop/switch region; other site 1302650009286 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1302650009287 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1302650009288 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1302650009289 TM-ABC transporter signature motif; other site 1302650009290 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1302650009291 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1302650009292 TM-ABC transporter signature motif; other site 1302650009293 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1302650009294 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1302650009295 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1302650009296 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1302650009297 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1302650009298 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1302650009299 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1302650009300 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1302650009301 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1302650009302 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1302650009303 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1302650009304 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1302650009305 CoenzymeA binding site [chemical binding]; other site 1302650009306 subunit interaction site [polypeptide binding]; other site 1302650009307 PHB binding site; other site 1302650009308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650009309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650009310 active site 1302650009311 phosphorylation site [posttranslational modification] 1302650009312 intermolecular recognition site; other site 1302650009313 dimerization interface [polypeptide binding]; other site 1302650009314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650009315 DNA binding residues [nucleotide binding] 1302650009316 dimerization interface [polypeptide binding]; other site 1302650009317 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1302650009318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302650009319 Histidine kinase; Region: HisKA_3; pfam07730 1302650009320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650009321 ATP binding site [chemical binding]; other site 1302650009322 Mg2+ binding site [ion binding]; other site 1302650009323 G-X-G motif; other site 1302650009324 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1302650009325 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1302650009326 substrate binding pocket [chemical binding]; other site 1302650009327 substrate-Mg2+ binding site; other site 1302650009328 aspartate-rich region 1; other site 1302650009329 aspartate-rich region 2; other site 1302650009330 DegQ (SacQ) family; Region: DegQ; pfam08181 1302650009331 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1302650009332 EAL domain; Region: EAL; pfam00563 1302650009333 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1302650009334 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1302650009335 active site 1302650009336 Isochorismatase family; Region: Isochorismatase; pfam00857 1302650009337 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1302650009338 catalytic triad [active] 1302650009339 conserved cis-peptide bond; other site 1302650009340 Uncharacterized conserved protein [Function unknown]; Region: COG5506 1302650009341 YueH-like protein; Region: YueH; pfam14166 1302650009342 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1302650009343 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1302650009344 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1302650009345 Uncharacterized conserved small protein [Function unknown]; Region: COG5428 1302650009346 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1302650009347 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1302650009348 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302650009349 Zn2+ binding site [ion binding]; other site 1302650009350 Mg2+ binding site [ion binding]; other site 1302650009351 short chain dehydrogenase; Provisional; Region: PRK06924 1302650009352 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1302650009353 NADP binding site [chemical binding]; other site 1302650009354 homodimer interface [polypeptide binding]; other site 1302650009355 active site 1302650009356 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1302650009357 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1302650009358 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1302650009359 Predicted membrane protein [Function unknown]; Region: COG1511 1302650009360 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1302650009361 potential frameshift: common BLAST hit: gi|449095630|ref|YP_007428121.1| putative cell division protein 1302650009362 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1302650009363 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1302650009364 Uncharacterized small protein [Function unknown]; Region: COG5417 1302650009365 Ubiquitin homologues; Region: UBQ; smart00213 1302650009366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1302650009367 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1302650009368 CodY GAF-like domain; Region: CodY; pfam06018 1302650009369 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1302650009370 alanine dehydrogenase; Region: alaDH; TIGR00518 1302650009371 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1302650009372 hexamer interface [polypeptide binding]; other site 1302650009373 ligand binding site [chemical binding]; other site 1302650009374 putative active site [active] 1302650009375 NAD(P) binding site [chemical binding]; other site 1302650009376 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1302650009377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1302650009378 Condensation domain; Region: Condensation; pfam00668 1302650009379 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1302650009380 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1302650009381 acyl-activating enzyme (AAE) consensus motif; other site 1302650009382 AMP binding site [chemical binding]; other site 1302650009383 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650009384 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1302650009385 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1302650009386 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1302650009387 acyl-activating enzyme (AAE) consensus motif; other site 1302650009388 AMP binding site [chemical binding]; other site 1302650009389 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1302650009390 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1302650009391 hydrophobic substrate binding pocket; other site 1302650009392 Isochorismatase family; Region: Isochorismatase; pfam00857 1302650009393 active site 1302650009394 conserved cis-peptide bond; other site 1302650009395 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1302650009396 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1302650009397 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1302650009398 acyl-activating enzyme (AAE) consensus motif; other site 1302650009399 active site 1302650009400 AMP binding site [chemical binding]; other site 1302650009401 substrate binding site [chemical binding]; other site 1302650009402 isochorismate synthase DhbC; Validated; Region: PRK06923 1302650009403 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1302650009404 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1302650009405 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1302650009406 putative NAD(P) binding site [chemical binding]; other site 1302650009407 active site 1302650009408 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1302650009409 Putative esterase; Region: Esterase; pfam00756 1302650009410 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1302650009411 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1302650009412 Moco binding site; other site 1302650009413 metal coordination site [ion binding]; other site 1302650009414 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1302650009415 Predicted permease [General function prediction only]; Region: COG2056 1302650009416 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1302650009417 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1302650009418 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1302650009419 interface (dimer of trimers) [polypeptide binding]; other site 1302650009420 Substrate-binding/catalytic site; other site 1302650009421 Zn-binding sites [ion binding]; other site 1302650009422 Divergent PAP2 family; Region: DUF212; pfam02681 1302650009423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1302650009424 Putative membrane protein; Region: YuiB; pfam14068 1302650009425 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1302650009426 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1302650009427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650009428 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1302650009429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1302650009430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650009431 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1302650009432 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1302650009433 active site 1302650009434 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1302650009435 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302650009436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650009437 Coenzyme A binding pocket [chemical binding]; other site 1302650009438 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1302650009439 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1302650009440 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1302650009441 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1302650009442 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1302650009443 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1302650009444 Nucleoside recognition; Region: Gate; pfam07670 1302650009445 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1302650009446 hypothetical protein; Provisional; Region: PRK13669 1302650009447 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1302650009448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650009449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1302650009450 NifU-like domain; Region: NifU; pfam01106 1302650009451 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1302650009452 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1302650009453 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1302650009454 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1302650009455 homoserine kinase; Region: thrB; TIGR00191 1302650009456 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1302650009457 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1302650009458 threonine synthase; Reviewed; Region: PRK06721 1302650009459 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1302650009460 homodimer interface [polypeptide binding]; other site 1302650009461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650009462 catalytic residue [active] 1302650009463 homoserine dehydrogenase; Provisional; Region: PRK06349 1302650009464 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1302650009465 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1302650009466 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1302650009467 spore coat protein YutH; Region: spore_yutH; TIGR02905 1302650009468 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1302650009469 tetramer interfaces [polypeptide binding]; other site 1302650009470 binuclear metal-binding site [ion binding]; other site 1302650009471 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1302650009472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650009473 active site 1302650009474 motif I; other site 1302650009475 motif II; other site 1302650009476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650009477 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1302650009478 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1302650009479 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1302650009480 lipoyl synthase; Provisional; Region: PRK05481 1302650009481 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650009482 FeS/SAM binding site; other site 1302650009483 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1302650009484 Peptidase family M23; Region: Peptidase_M23; pfam01551 1302650009485 sporulation protein YunB; Region: spo_yunB; TIGR02832 1302650009486 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1302650009487 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1302650009488 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1302650009489 active site 1302650009490 metal binding site [ion binding]; metal-binding site 1302650009491 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1302650009492 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1302650009493 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1302650009494 allantoinase; Provisional; Region: PRK06189 1302650009495 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1302650009496 active site 1302650009497 DRTGG domain; Region: DRTGG; pfam07085 1302650009498 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1302650009499 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1302650009500 xanthine permease; Region: pbuX; TIGR03173 1302650009501 xanthine permease; Region: pbuX; TIGR03173 1302650009502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1302650009503 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1302650009504 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1302650009505 active site 1302650009506 Transthyretin-like protein [General function prediction only]; Region: COG2351 1302650009507 active site 1302650009508 homotetramer interface [polypeptide binding]; other site 1302650009509 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1302650009510 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1302650009511 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1302650009512 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1302650009513 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1302650009514 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1302650009515 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1302650009516 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1302650009517 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1302650009518 Ligand binding site; other site 1302650009519 metal-binding site 1302650009520 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1302650009521 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1302650009522 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1302650009523 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1302650009524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302650009525 catalytic residue [active] 1302650009526 allantoate amidohydrolase; Reviewed; Region: PRK09290 1302650009527 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1302650009528 active site 1302650009529 metal binding site [ion binding]; metal-binding site 1302650009530 dimer interface [polypeptide binding]; other site 1302650009531 Endonuclease I; Region: Endonuclease_1; cl01003 1302650009532 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1302650009533 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1302650009534 Walker A/P-loop; other site 1302650009535 ATP binding site [chemical binding]; other site 1302650009536 Q-loop/lid; other site 1302650009537 ABC transporter signature motif; other site 1302650009538 Walker B; other site 1302650009539 D-loop; other site 1302650009540 H-loop/switch region; other site 1302650009541 TOBE domain; Region: TOBE_2; pfam08402 1302650009542 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1302650009543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650009544 DNA-binding site [nucleotide binding]; DNA binding site 1302650009545 UTRA domain; Region: UTRA; pfam07702 1302650009546 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1302650009547 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1302650009548 substrate binding site [chemical binding]; other site 1302650009549 ATP binding site [chemical binding]; other site 1302650009550 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302650009551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650009552 dimer interface [polypeptide binding]; other site 1302650009553 conserved gate region; other site 1302650009554 putative PBP binding loops; other site 1302650009555 ABC-ATPase subunit interface; other site 1302650009556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650009557 dimer interface [polypeptide binding]; other site 1302650009558 conserved gate region; other site 1302650009559 putative PBP binding loops; other site 1302650009560 ABC-ATPase subunit interface; other site 1302650009561 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1302650009562 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302650009563 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1302650009564 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1302650009565 putative active site [active] 1302650009566 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1302650009567 dimer interface [polypeptide binding]; other site 1302650009568 active site 1302650009569 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1302650009570 GIY-YIG motif/motif A; other site 1302650009571 active site 1302650009572 catalytic site [active] 1302650009573 putative DNA binding site [nucleotide binding]; other site 1302650009574 metal binding site [ion binding]; metal-binding site 1302650009575 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1302650009576 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1302650009577 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650009578 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1302650009579 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650009580 dimerization interface [polypeptide binding]; other site 1302650009581 putative DNA binding site [nucleotide binding]; other site 1302650009582 putative Zn2+ binding site [ion binding]; other site 1302650009583 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1302650009584 FeS assembly protein SufB; Region: sufB; TIGR01980 1302650009585 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1302650009586 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1302650009587 trimerization site [polypeptide binding]; other site 1302650009588 active site 1302650009589 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1302650009590 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1302650009591 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302650009592 catalytic residue [active] 1302650009593 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1302650009594 FeS assembly protein SufD; Region: sufD; TIGR01981 1302650009595 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1302650009596 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1302650009597 Walker A/P-loop; other site 1302650009598 ATP binding site [chemical binding]; other site 1302650009599 Q-loop/lid; other site 1302650009600 ABC transporter signature motif; other site 1302650009601 Walker B; other site 1302650009602 D-loop; other site 1302650009603 H-loop/switch region; other site 1302650009604 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1302650009605 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1302650009606 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1302650009607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650009608 conserved gate region; other site 1302650009609 ABC-ATPase subunit interface; other site 1302650009610 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1302650009611 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1302650009612 Walker A/P-loop; other site 1302650009613 ATP binding site [chemical binding]; other site 1302650009614 Q-loop/lid; other site 1302650009615 ABC transporter signature motif; other site 1302650009616 Walker B; other site 1302650009617 D-loop; other site 1302650009618 H-loop/switch region; other site 1302650009619 NIL domain; Region: NIL; pfam09383 1302650009620 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1302650009621 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302650009622 catalytic residues [active] 1302650009623 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1302650009624 putative active site [active] 1302650009625 putative metal binding site [ion binding]; other site 1302650009626 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1302650009627 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1302650009628 lipoyl attachment site [posttranslational modification]; other site 1302650009629 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1302650009630 ArsC family; Region: ArsC; pfam03960 1302650009631 putative ArsC-like catalytic residues; other site 1302650009632 putative TRX-like catalytic residues [active] 1302650009633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1302650009634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1302650009635 active site 1302650009636 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1302650009637 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1302650009638 dimer interface [polypeptide binding]; other site 1302650009639 active site 1302650009640 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1302650009641 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1302650009642 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1302650009643 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1302650009644 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1302650009645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1302650009646 substrate binding site [chemical binding]; other site 1302650009647 oxyanion hole (OAH) forming residues; other site 1302650009648 trimer interface [polypeptide binding]; other site 1302650009649 Proline dehydrogenase; Region: Pro_dh; pfam01619 1302650009650 Coat F domain; Region: Coat_F; pfam07875 1302650009651 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650009652 MarR family; Region: MarR; pfam01047 1302650009653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650009654 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650009655 putative substrate translocation pore; other site 1302650009656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650009657 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1302650009658 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1302650009659 classical (c) SDRs; Region: SDR_c; cd05233 1302650009660 NAD(P) binding site [chemical binding]; other site 1302650009661 active site 1302650009662 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650009663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650009664 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1302650009665 putative dimerization interface [polypeptide binding]; other site 1302650009666 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1302650009667 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1302650009668 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1302650009669 Walker A/P-loop; other site 1302650009670 ATP binding site [chemical binding]; other site 1302650009671 Q-loop/lid; other site 1302650009672 ABC transporter signature motif; other site 1302650009673 Walker B; other site 1302650009674 D-loop; other site 1302650009675 H-loop/switch region; other site 1302650009676 YusW-like protein; Region: YusW; pfam14039 1302650009677 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1302650009678 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1302650009679 active site 1302650009680 Zn binding site [ion binding]; other site 1302650009681 short chain dehydrogenase; Provisional; Region: PRK06914 1302650009682 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1302650009683 NADP binding site [chemical binding]; other site 1302650009684 active site 1302650009685 steroid binding site; other site 1302650009686 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1302650009687 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1302650009688 dimerization interface [polypeptide binding]; other site 1302650009689 DPS ferroxidase diiron center [ion binding]; other site 1302650009690 ion pore; other site 1302650009691 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1302650009692 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1302650009693 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1302650009694 protein binding site [polypeptide binding]; other site 1302650009695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650009696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650009697 active site 1302650009698 phosphorylation site [posttranslational modification] 1302650009699 intermolecular recognition site; other site 1302650009700 dimerization interface [polypeptide binding]; other site 1302650009701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650009702 DNA binding site [nucleotide binding] 1302650009703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650009704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650009705 dimerization interface [polypeptide binding]; other site 1302650009706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650009707 dimer interface [polypeptide binding]; other site 1302650009708 phosphorylation site [posttranslational modification] 1302650009709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650009710 ATP binding site [chemical binding]; other site 1302650009711 Mg2+ binding site [ion binding]; other site 1302650009712 G-X-G motif; other site 1302650009713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650009714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650009715 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1302650009716 Class II fumarases; Region: Fumarase_classII; cd01362 1302650009717 active site 1302650009718 tetramer interface [polypeptide binding]; other site 1302650009719 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1302650009720 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1302650009721 Spore germination protein; Region: Spore_permease; pfam03845 1302650009722 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1302650009723 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1302650009724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650009725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650009726 active site 1302650009727 phosphorylation site [posttranslational modification] 1302650009728 intermolecular recognition site; other site 1302650009729 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650009730 DNA binding residues [nucleotide binding] 1302650009731 dimerization interface [polypeptide binding]; other site 1302650009732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302650009733 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650009734 dimerization interface [polypeptide binding]; other site 1302650009735 Histidine kinase; Region: HisKA_3; pfam07730 1302650009736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650009737 ATP binding site [chemical binding]; other site 1302650009738 Mg2+ binding site [ion binding]; other site 1302650009739 G-X-G motif; other site 1302650009740 Predicted membrane protein [Function unknown]; Region: COG4758 1302650009741 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1302650009742 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1302650009743 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1302650009744 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1302650009745 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1302650009746 PspA/IM30 family; Region: PspA_IM30; pfam04012 1302650009747 potential frameshift: common BLAST hit: gi|16080367|ref|NP_391194.1| efflux protein 1302650009748 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 1302650009749 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1302650009750 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1302650009751 Walker A/P-loop; other site 1302650009752 ATP binding site [chemical binding]; other site 1302650009753 Q-loop/lid; other site 1302650009754 ABC transporter signature motif; other site 1302650009755 Walker B; other site 1302650009756 D-loop; other site 1302650009757 H-loop/switch region; other site 1302650009758 Adenosylcobinamide amidohydrolase [Coenzyme metabolism]; Region: cbiZ; COG1865 1302650009759 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1302650009760 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650009761 ABC-ATPase subunit interface; other site 1302650009762 dimer interface [polypeptide binding]; other site 1302650009763 putative PBP binding regions; other site 1302650009764 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1302650009765 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1302650009766 putative binding site residues; other site 1302650009767 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1302650009768 classical (c) SDRs; Region: SDR_c; cd05233 1302650009769 NAD(P) binding site [chemical binding]; other site 1302650009770 active site 1302650009771 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1302650009772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650009773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650009774 dimer interface [polypeptide binding]; other site 1302650009775 phosphorylation site [posttranslational modification] 1302650009776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650009777 ATP binding site [chemical binding]; other site 1302650009778 Mg2+ binding site [ion binding]; other site 1302650009779 G-X-G motif; other site 1302650009780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650009781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650009782 active site 1302650009783 phosphorylation site [posttranslational modification] 1302650009784 intermolecular recognition site; other site 1302650009785 dimerization interface [polypeptide binding]; other site 1302650009786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650009787 DNA binding site [nucleotide binding] 1302650009788 hypothetical protein; Provisional; Region: PRK14082 1302650009789 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1302650009790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650009791 DNA binding residues [nucleotide binding] 1302650009792 YvrJ protein family; Region: YvrJ; pfam12841 1302650009793 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1302650009794 Cupin; Region: Cupin_1; smart00835 1302650009795 Cupin; Region: Cupin_1; smart00835 1302650009796 Regulatory protein YrvL; Region: YrvL; pfam14184 1302650009797 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1302650009798 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302650009799 FtsX-like permease family; Region: FtsX; pfam02687 1302650009800 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302650009801 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302650009802 Walker A/P-loop; other site 1302650009803 ATP binding site [chemical binding]; other site 1302650009804 Q-loop/lid; other site 1302650009805 ABC transporter signature motif; other site 1302650009806 Walker B; other site 1302650009807 D-loop; other site 1302650009808 H-loop/switch region; other site 1302650009809 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1302650009810 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1302650009811 HlyD family secretion protein; Region: HlyD_3; pfam13437 1302650009812 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1302650009813 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1302650009814 Walker A/P-loop; other site 1302650009815 ATP binding site [chemical binding]; other site 1302650009816 Q-loop/lid; other site 1302650009817 ABC transporter signature motif; other site 1302650009818 Walker B; other site 1302650009819 D-loop; other site 1302650009820 H-loop/switch region; other site 1302650009821 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1302650009822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650009823 ABC-ATPase subunit interface; other site 1302650009824 dimer interface [polypeptide binding]; other site 1302650009825 putative PBP binding regions; other site 1302650009826 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1302650009827 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302650009828 ABC-ATPase subunit interface; other site 1302650009829 dimer interface [polypeptide binding]; other site 1302650009830 putative PBP binding regions; other site 1302650009831 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1302650009832 putative ligand binding residues [chemical binding]; other site 1302650009833 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1302650009834 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1302650009835 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 1302650009836 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1302650009837 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1302650009838 Sulfatase; Region: Sulfatase; pfam00884 1302650009839 DNA binding domain, excisionase family; Region: excise; TIGR01764 1302650009840 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1302650009841 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1302650009842 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1302650009843 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1302650009844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650009845 dimer interface [polypeptide binding]; other site 1302650009846 conserved gate region; other site 1302650009847 putative PBP binding loops; other site 1302650009848 ABC-ATPase subunit interface; other site 1302650009849 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302650009850 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302650009851 active site 1302650009852 catalytic tetrad [active] 1302650009853 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1302650009854 sulfite reductase subunit beta; Provisional; Region: PRK13504 1302650009855 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1302650009856 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1302650009857 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1302650009858 Flavodoxin; Region: Flavodoxin_1; pfam00258 1302650009859 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1302650009860 FAD binding pocket [chemical binding]; other site 1302650009861 FAD binding motif [chemical binding]; other site 1302650009862 catalytic residues [active] 1302650009863 NAD binding pocket [chemical binding]; other site 1302650009864 phosphate binding motif [ion binding]; other site 1302650009865 beta-alpha-beta structure motif; other site 1302650009866 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1302650009867 Part of AAA domain; Region: AAA_19; pfam13245 1302650009868 Family description; Region: UvrD_C_2; pfam13538 1302650009869 Predicted membrane protein [Function unknown]; Region: COG2860 1302650009870 UPF0126 domain; Region: UPF0126; pfam03458 1302650009871 UPF0126 domain; Region: UPF0126; pfam03458 1302650009872 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1302650009873 Thioredoxin; Region: Thioredoxin_4; pfam13462 1302650009874 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1302650009875 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1302650009876 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1302650009877 metal-binding site [ion binding] 1302650009878 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302650009879 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1302650009880 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1302650009881 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1302650009882 metal-binding site [ion binding] 1302650009883 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1302650009884 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1302650009885 metal-binding site [ion binding] 1302650009886 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302650009887 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1302650009888 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1302650009889 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1302650009890 metal-binding site [ion binding] 1302650009891 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1302650009892 putative homodimer interface [polypeptide binding]; other site 1302650009893 putative homotetramer interface [polypeptide binding]; other site 1302650009894 allosteric switch controlling residues; other site 1302650009895 putative metal binding site [ion binding]; other site 1302650009896 putative homodimer-homodimer interface [polypeptide binding]; other site 1302650009897 putative oxidoreductase; Provisional; Region: PRK11579 1302650009898 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1302650009899 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1302650009900 azoreductase; Reviewed; Region: PRK00170 1302650009901 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1302650009902 Predicted membrane protein [Function unknown]; Region: COG1289 1302650009903 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1302650009904 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1302650009905 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1302650009906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650009907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650009908 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1302650009909 classical (c) SDRs; Region: SDR_c; cd05233 1302650009910 NAD(P) binding site [chemical binding]; other site 1302650009911 active site 1302650009912 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1302650009913 SmpB-tmRNA interface; other site 1302650009914 ribonuclease R; Region: RNase_R; TIGR02063 1302650009915 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1302650009916 Cold shock protein domain; Region: CSP; smart00357 1302650009917 RNB domain; Region: RNB; pfam00773 1302650009918 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1302650009919 RNA binding site [nucleotide binding]; other site 1302650009920 Esterase/lipase [General function prediction only]; Region: COG1647 1302650009921 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1302650009922 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650009923 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1302650009924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650009925 salt bridge; other site 1302650009926 non-specific DNA binding site [nucleotide binding]; other site 1302650009927 sequence-specific DNA binding site [nucleotide binding]; other site 1302650009928 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302650009929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650009930 non-specific DNA binding site [nucleotide binding]; other site 1302650009931 salt bridge; other site 1302650009932 sequence-specific DNA binding site [nucleotide binding]; other site 1302650009933 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302650009934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650009935 non-specific DNA binding site [nucleotide binding]; other site 1302650009936 salt bridge; other site 1302650009937 sequence-specific DNA binding site [nucleotide binding]; other site 1302650009938 Predicted transcriptional regulators [Transcription]; Region: COG1733 1302650009939 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650009940 dimerization interface [polypeptide binding]; other site 1302650009941 putative DNA binding site [nucleotide binding]; other site 1302650009942 putative Zn2+ binding site [ion binding]; other site 1302650009943 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1302650009944 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 1302650009945 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1302650009946 active site 1302650009947 catalytic residues [active] 1302650009948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650009949 dimer interface [polypeptide binding]; other site 1302650009950 conserved gate region; other site 1302650009951 putative PBP binding loops; other site 1302650009952 ABC-ATPase subunit interface; other site 1302650009953 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1302650009954 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1302650009955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650009956 dimer interface [polypeptide binding]; other site 1302650009957 conserved gate region; other site 1302650009958 putative PBP binding loops; other site 1302650009959 ABC-ATPase subunit interface; other site 1302650009960 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1302650009961 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1302650009962 Walker A/P-loop; other site 1302650009963 ATP binding site [chemical binding]; other site 1302650009964 Q-loop/lid; other site 1302650009965 ABC transporter signature motif; other site 1302650009966 Walker B; other site 1302650009967 D-loop; other site 1302650009968 H-loop/switch region; other site 1302650009969 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1302650009970 Predicted transcriptional regulators [Transcription]; Region: COG1510 1302650009971 MarR family; Region: MarR_2; pfam12802 1302650009972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650009973 dimer interface [polypeptide binding]; other site 1302650009974 conserved gate region; other site 1302650009975 putative PBP binding loops; other site 1302650009976 ABC-ATPase subunit interface; other site 1302650009977 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1302650009978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650009979 dimer interface [polypeptide binding]; other site 1302650009980 conserved gate region; other site 1302650009981 putative PBP binding loops; other site 1302650009982 ABC-ATPase subunit interface; other site 1302650009983 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1302650009984 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1302650009985 Walker A/P-loop; other site 1302650009986 ATP binding site [chemical binding]; other site 1302650009987 Q-loop/lid; other site 1302650009988 ABC transporter signature motif; other site 1302650009989 Walker B; other site 1302650009990 D-loop; other site 1302650009991 H-loop/switch region; other site 1302650009992 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1302650009993 Predicted transcriptional regulators [Transcription]; Region: COG1510 1302650009994 MarR family; Region: MarR_2; pfam12802 1302650009995 membrane protein, MarC family; Region: TIGR00427 1302650009996 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1302650009997 pentamer interface [polypeptide binding]; other site 1302650009998 dodecaamer interface [polypeptide binding]; other site 1302650009999 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1302650010000 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1302650010001 Double zinc ribbon; Region: DZR; pfam12773 1302650010002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1302650010003 Predicted membrane protein [Function unknown]; Region: COG4640 1302650010004 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1302650010005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650010006 Coenzyme A binding pocket [chemical binding]; other site 1302650010007 H+ Antiporter protein; Region: 2A0121; TIGR00900 1302650010008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650010009 putative substrate translocation pore; other site 1302650010010 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1302650010011 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1302650010012 WbqC-like protein family; Region: WbqC; pfam08889 1302650010013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1302650010014 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1302650010015 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1302650010016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302650010017 catalytic residue [active] 1302650010018 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1302650010019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1302650010020 NAD(P) binding site [chemical binding]; other site 1302650010021 active site 1302650010022 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1302650010023 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1302650010024 inhibitor-cofactor binding pocket; inhibition site 1302650010025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650010026 catalytic residue [active] 1302650010027 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1302650010028 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1302650010029 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1302650010030 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1302650010031 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1302650010032 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1302650010033 putative integrin binding motif; other site 1302650010034 PA/protease domain interface [polypeptide binding]; other site 1302650010035 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1302650010036 Peptidase family M28; Region: Peptidase_M28; pfam04389 1302650010037 metal binding site [ion binding]; metal-binding site 1302650010038 enolase; Provisional; Region: eno; PRK00077 1302650010039 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1302650010040 dimer interface [polypeptide binding]; other site 1302650010041 metal binding site [ion binding]; metal-binding site 1302650010042 substrate binding pocket [chemical binding]; other site 1302650010043 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1302650010044 phosphoglyceromutase; Provisional; Region: PRK05434 1302650010045 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1302650010046 triosephosphate isomerase; Provisional; Region: PRK14565 1302650010047 substrate binding site [chemical binding]; other site 1302650010048 dimer interface [polypeptide binding]; other site 1302650010049 catalytic triad [active] 1302650010050 Phosphoglycerate kinase; Region: PGK; pfam00162 1302650010051 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1302650010052 substrate binding site [chemical binding]; other site 1302650010053 hinge regions; other site 1302650010054 ADP binding site [chemical binding]; other site 1302650010055 catalytic site [active] 1302650010056 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1302650010057 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1302650010058 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1302650010059 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1302650010060 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1302650010061 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1302650010062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650010063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650010064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650010065 DNA-binding site [nucleotide binding]; DNA binding site 1302650010066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650010067 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1302650010068 putative dimerization interface [polypeptide binding]; other site 1302650010069 putative ligand binding site [chemical binding]; other site 1302650010070 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1302650010071 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1302650010072 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1302650010073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650010074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650010075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302650010076 dimerization interface [polypeptide binding]; other site 1302650010077 EamA-like transporter family; Region: EamA; pfam00892 1302650010078 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1302650010079 EamA-like transporter family; Region: EamA; pfam00892 1302650010080 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1302650010081 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1302650010082 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1302650010083 active site 1302650010084 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1302650010085 iron-sulfur cluster-binding protein; Region: TIGR00273 1302650010086 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1302650010087 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1302650010088 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1302650010089 Cysteine-rich domain; Region: CCG; pfam02754 1302650010090 Cysteine-rich domain; Region: CCG; pfam02754 1302650010091 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650010092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650010093 active site 1302650010094 phosphorylation site [posttranslational modification] 1302650010095 intermolecular recognition site; other site 1302650010096 dimerization interface [polypeptide binding]; other site 1302650010097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650010098 DNA binding residues [nucleotide binding] 1302650010099 dimerization interface [polypeptide binding]; other site 1302650010100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302650010101 Histidine kinase; Region: HisKA_3; pfam07730 1302650010102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650010103 ATP binding site [chemical binding]; other site 1302650010104 Mg2+ binding site [ion binding]; other site 1302650010105 G-X-G motif; other site 1302650010106 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1302650010107 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1302650010108 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302650010109 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302650010110 Walker A/P-loop; other site 1302650010111 ATP binding site [chemical binding]; other site 1302650010112 Q-loop/lid; other site 1302650010113 ABC transporter signature motif; other site 1302650010114 Walker B; other site 1302650010115 D-loop; other site 1302650010116 H-loop/switch region; other site 1302650010117 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302650010118 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1302650010119 catalytic site [active] 1302650010120 PAS domain S-box; Region: sensory_box; TIGR00229 1302650010121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650010122 putative active site [active] 1302650010123 heme pocket [chemical binding]; other site 1302650010124 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1302650010125 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1302650010126 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1302650010127 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1302650010128 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1302650010129 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1302650010130 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1302650010131 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302650010132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650010133 dimer interface [polypeptide binding]; other site 1302650010134 conserved gate region; other site 1302650010135 putative PBP binding loops; other site 1302650010136 ABC-ATPase subunit interface; other site 1302650010137 TM2 domain; Region: TM2; pfam05154 1302650010138 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1302650010139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650010140 dimer interface [polypeptide binding]; other site 1302650010141 conserved gate region; other site 1302650010142 ABC-ATPase subunit interface; other site 1302650010143 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1302650010144 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302650010145 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650010146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650010147 DNA binding site [nucleotide binding] 1302650010148 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1302650010149 putative dimerization interface [polypeptide binding]; other site 1302650010150 putative ligand binding site [chemical binding]; other site 1302650010151 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1302650010152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650010153 DNA-binding site [nucleotide binding]; DNA binding site 1302650010154 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1302650010155 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1302650010156 L-lactate permease; Region: Lactate_perm; pfam02652 1302650010157 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1302650010158 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1302650010159 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1302650010160 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1302650010161 YvfG protein; Region: YvfG; pfam09628 1302650010162 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1302650010163 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1302650010164 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1302650010165 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1302650010166 inhibitor-cofactor binding pocket; inhibition site 1302650010167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650010168 catalytic residue [active] 1302650010169 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1302650010170 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1302650010171 putative trimer interface [polypeptide binding]; other site 1302650010172 putative CoA binding site [chemical binding]; other site 1302650010173 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1302650010174 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1302650010175 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1302650010176 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650010177 active site 1302650010178 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1302650010179 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1302650010180 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650010181 active site 1302650010182 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302650010183 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1302650010184 putative ADP-binding pocket [chemical binding]; other site 1302650010185 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650010186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1302650010187 active site 1302650010188 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1302650010189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302650010190 putative ADP-binding pocket [chemical binding]; other site 1302650010191 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1302650010192 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1302650010193 NAD(P) binding site [chemical binding]; other site 1302650010194 homodimer interface [polypeptide binding]; other site 1302650010195 substrate binding site [chemical binding]; other site 1302650010196 active site 1302650010197 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1302650010198 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1302650010199 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1302650010200 Chain length determinant protein; Region: Wzz; cl15801 1302650010201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302650010202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650010203 non-specific DNA binding site [nucleotide binding]; other site 1302650010204 salt bridge; other site 1302650010205 sequence-specific DNA binding site [nucleotide binding]; other site 1302650010206 Anti-repressor SinI; Region: SinI; pfam08671 1302650010207 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1302650010208 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1302650010209 substrate binding pocket [chemical binding]; other site 1302650010210 catalytic triad [active] 1302650010211 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1302650010212 hypothetical protein; Provisional; Region: PRK00872 1302650010213 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1302650010214 aspartate racemase; Region: asp_race; TIGR00035 1302650010215 potential frameshift: common BLAST hit: gi|430758155|ref|YP_007208052.1| Penicillin-binding protein PbpE 1302650010216 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1302650010217 active site 1302650010218 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1302650010219 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1302650010220 substrate binding [chemical binding]; other site 1302650010221 active site 1302650010222 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1302650010223 amino acid transporter; Region: 2A0306; TIGR00909 1302650010224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650010225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650010226 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1302650010227 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1302650010228 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1302650010229 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1302650010230 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 1302650010231 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1302650010232 Clp protease; Region: CLP_protease; pfam00574 1302650010233 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1302650010234 oligomer interface [polypeptide binding]; other site 1302650010235 active site residues [active] 1302650010236 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1302650010237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650010238 motif II; other site 1302650010239 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1302650010240 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1302650010241 Ca binding site [ion binding]; other site 1302650010242 active site 1302650010243 catalytic site [active] 1302650010244 maltose phosphorylase; Provisional; Region: PRK13807 1302650010245 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1302650010246 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1302650010247 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1302650010248 Predicted integral membrane protein [Function unknown]; Region: COG5521 1302650010249 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302650010250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650010251 dimer interface [polypeptide binding]; other site 1302650010252 conserved gate region; other site 1302650010253 ABC-ATPase subunit interface; other site 1302650010254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650010255 dimer interface [polypeptide binding]; other site 1302650010256 conserved gate region; other site 1302650010257 putative PBP binding loops; other site 1302650010258 ABC-ATPase subunit interface; other site 1302650010259 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1302650010260 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302650010261 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1302650010262 homodimer interface [polypeptide binding]; other site 1302650010263 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1302650010264 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1302650010265 active site 1302650010266 homodimer interface [polypeptide binding]; other site 1302650010267 catalytic site [active] 1302650010268 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650010269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650010270 DNA binding site [nucleotide binding] 1302650010271 domain linker motif; other site 1302650010272 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1302650010273 ligand binding site [chemical binding]; other site 1302650010274 dimerization interface [polypeptide binding]; other site 1302650010275 TIGR00730 family protein; Region: TIGR00730 1302650010276 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1302650010277 metal binding site [ion binding]; metal-binding site 1302650010278 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1302650010279 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1302650010280 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1302650010281 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1302650010282 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1302650010283 active site clefts [active] 1302650010284 zinc binding site [ion binding]; other site 1302650010285 dimer interface [polypeptide binding]; other site 1302650010286 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1302650010287 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1302650010288 dimerization interface [polypeptide binding]; other site 1302650010289 ligand binding site [chemical binding]; other site 1302650010290 NADP binding site [chemical binding]; other site 1302650010291 catalytic site [active] 1302650010292 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302650010293 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302650010294 Walker A/P-loop; other site 1302650010295 ATP binding site [chemical binding]; other site 1302650010296 Q-loop/lid; other site 1302650010297 ABC transporter signature motif; other site 1302650010298 Walker B; other site 1302650010299 D-loop; other site 1302650010300 H-loop/switch region; other site 1302650010301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650010302 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1302650010303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650010304 ATP binding site [chemical binding]; other site 1302650010305 Mg2+ binding site [ion binding]; other site 1302650010306 G-X-G motif; other site 1302650010307 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650010308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650010309 active site 1302650010310 phosphorylation site [posttranslational modification] 1302650010311 intermolecular recognition site; other site 1302650010312 dimerization interface [polypeptide binding]; other site 1302650010313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650010314 DNA binding site [nucleotide binding] 1302650010315 Lysis protein; Region: Lysis_col; pfam02402 1302650010316 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1302650010317 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1302650010318 dimerization domain swap beta strand [polypeptide binding]; other site 1302650010319 regulatory protein interface [polypeptide binding]; other site 1302650010320 active site 1302650010321 regulatory phosphorylation site [posttranslational modification]; other site 1302650010322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1302650010323 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1302650010324 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1302650010325 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1302650010326 phosphate binding site [ion binding]; other site 1302650010327 putative substrate binding pocket [chemical binding]; other site 1302650010328 dimer interface [polypeptide binding]; other site 1302650010329 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1302650010330 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1302650010331 putative active site [active] 1302650010332 nucleotide binding site [chemical binding]; other site 1302650010333 nudix motif; other site 1302650010334 putative metal binding site [ion binding]; other site 1302650010335 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1302650010336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1302650010337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650010338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1302650010339 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1302650010340 NlpC/P60 family; Region: NLPC_P60; pfam00877 1302650010341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650010342 binding surface 1302650010343 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1302650010344 TPR motif; other site 1302650010345 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1302650010346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650010347 TPR motif; other site 1302650010348 binding surface 1302650010349 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302650010350 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650010351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650010352 Walker A/P-loop; other site 1302650010353 ATP binding site [chemical binding]; other site 1302650010354 Q-loop/lid; other site 1302650010355 ABC transporter signature motif; other site 1302650010356 Walker B; other site 1302650010357 D-loop; other site 1302650010358 H-loop/switch region; other site 1302650010359 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1302650010360 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1302650010361 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1302650010362 metal binding site [ion binding]; metal-binding site 1302650010363 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1302650010364 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1302650010365 substrate binding site [chemical binding]; other site 1302650010366 glutamase interaction surface [polypeptide binding]; other site 1302650010367 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1302650010368 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1302650010369 catalytic residues [active] 1302650010370 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1302650010371 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1302650010372 putative active site [active] 1302650010373 oxyanion strand; other site 1302650010374 catalytic triad [active] 1302650010375 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1302650010376 putative active site pocket [active] 1302650010377 4-fold oligomerization interface [polypeptide binding]; other site 1302650010378 metal binding residues [ion binding]; metal-binding site 1302650010379 3-fold/trimer interface [polypeptide binding]; other site 1302650010380 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1302650010381 histidinol dehydrogenase; Region: hisD; TIGR00069 1302650010382 NAD binding site [chemical binding]; other site 1302650010383 dimerization interface [polypeptide binding]; other site 1302650010384 product binding site; other site 1302650010385 substrate binding site [chemical binding]; other site 1302650010386 zinc binding site [ion binding]; other site 1302650010387 catalytic residues [active] 1302650010388 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1302650010389 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1302650010390 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1302650010391 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1302650010392 dimer interface [polypeptide binding]; other site 1302650010393 motif 1; other site 1302650010394 active site 1302650010395 motif 2; other site 1302650010396 motif 3; other site 1302650010397 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1302650010398 putative active site [active] 1302650010399 Pectate lyase; Region: Pectate_lyase; pfam03211 1302650010400 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1302650010401 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1302650010402 trimer interface [polypeptide binding]; other site 1302650010403 active site 1302650010404 substrate binding site [chemical binding]; other site 1302650010405 CoA binding site [chemical binding]; other site 1302650010406 pyrophosphatase PpaX; Provisional; Region: PRK13288 1302650010407 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1302650010408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650010409 motif II; other site 1302650010410 Nucleoside recognition; Region: Gate; pfam07670 1302650010411 Nucleoside recognition; Region: Gate; pfam07670 1302650010412 potential frameshift: common BLAST hit: gi|430758212|ref|YP_007207995.1| Spore germination protein GerF 1302650010413 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1302650010414 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1302650010415 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1302650010416 Hpr binding site; other site 1302650010417 active site 1302650010418 homohexamer subunit interaction site [polypeptide binding]; other site 1302650010419 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1302650010420 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1302650010421 active site 1302650010422 dimer interface [polypeptide binding]; other site 1302650010423 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1302650010424 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1302650010425 active site 1302650010426 trimer interface [polypeptide binding]; other site 1302650010427 allosteric site; other site 1302650010428 active site lid [active] 1302650010429 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1302650010430 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1302650010431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650010432 DNA-binding site [nucleotide binding]; DNA binding site 1302650010433 UTRA domain; Region: UTRA; pfam07702 1302650010434 Lamin Tail Domain; Region: LTD; pfam00932 1302650010435 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1302650010436 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1302650010437 putative active site [active] 1302650010438 putative metal binding site [ion binding]; other site 1302650010439 Predicted membrane protein [Function unknown]; Region: COG1950 1302650010440 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1302650010441 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1302650010442 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1302650010443 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1302650010444 flagellin; Provisional; Region: PRK12804 1302650010445 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1302650010446 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1302650010447 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1302650010448 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1302650010449 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1302650010450 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1302650010451 excinuclease ABC subunit B; Provisional; Region: PRK05298 1302650010452 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650010453 ATP binding site [chemical binding]; other site 1302650010454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650010455 nucleotide binding region [chemical binding]; other site 1302650010456 ATP-binding site [chemical binding]; other site 1302650010457 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1302650010458 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1302650010459 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1302650010460 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 1302650010461 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1302650010462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650010463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650010464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650010465 putative substrate translocation pore; other site 1302650010466 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1302650010467 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1302650010468 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1302650010469 C-terminal peptidase (prc); Region: prc; TIGR00225 1302650010470 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1302650010471 protein binding site [polypeptide binding]; other site 1302650010472 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1302650010473 Catalytic dyad [active] 1302650010474 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1302650010475 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1302650010476 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1302650010477 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1302650010478 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 1302650010479 Walker A/P-loop; other site 1302650010480 ATP binding site [chemical binding]; other site 1302650010481 Q-loop/lid; other site 1302650010482 ABC transporter signature motif; other site 1302650010483 Walker B; other site 1302650010484 D-loop; other site 1302650010485 H-loop/switch region; other site 1302650010486 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1302650010487 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1302650010488 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1302650010489 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650010490 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650010491 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1302650010492 peptide chain release factor 2; Provisional; Region: PRK06746 1302650010493 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1302650010494 RF-1 domain; Region: RF-1; pfam00472 1302650010495 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1302650010496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1302650010497 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1302650010498 nucleotide binding region [chemical binding]; other site 1302650010499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1302650010500 ATP-binding site [chemical binding]; other site 1302650010501 SEC-C motif; Region: SEC-C; pfam02810 1302650010502 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1302650010503 30S subunit binding site; other site 1302650010504 Flagellar protein FliT; Region: FliT; pfam05400 1302650010505 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 1302650010506 flagellar capping protein; Validated; Region: fliD; PRK07737 1302650010507 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1302650010508 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1302650010509 flagellar protein FlaG; Provisional; Region: PRK07738 1302650010510 flagellin; Provisional; Region: PRK12804 1302650010511 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1302650010512 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1302650010513 carbon storage regulator; Provisional; Region: PRK01712 1302650010514 flagellar assembly protein FliW; Provisional; Region: PRK13285 1302650010515 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1302650010516 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1302650010517 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1302650010518 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1302650010519 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1302650010520 FlgN protein; Region: FlgN; pfam05130 1302650010521 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 1302650010522 flagellar operon protein TIGR03826; Region: YvyF 1302650010523 comF family protein; Region: comF; TIGR00201 1302650010524 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650010525 active site 1302650010526 Late competence development protein ComFB; Region: ComFB; pfam10719 1302650010527 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1302650010528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650010529 ATP binding site [chemical binding]; other site 1302650010530 putative Mg++ binding site [ion binding]; other site 1302650010531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650010532 nucleotide binding region [chemical binding]; other site 1302650010533 ATP-binding site [chemical binding]; other site 1302650010534 EDD domain protein, DegV family; Region: DegV; TIGR00762 1302650010535 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1302650010536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650010537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650010538 active site 1302650010539 phosphorylation site [posttranslational modification] 1302650010540 intermolecular recognition site; other site 1302650010541 dimerization interface [polypeptide binding]; other site 1302650010542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650010543 DNA binding residues [nucleotide binding] 1302650010544 dimerization interface [polypeptide binding]; other site 1302650010545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302650010546 Histidine kinase; Region: HisKA_3; pfam07730 1302650010547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650010548 ATP binding site [chemical binding]; other site 1302650010549 Mg2+ binding site [ion binding]; other site 1302650010550 G-X-G motif; other site 1302650010551 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1302650010552 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1302650010553 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1302650010554 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1302650010555 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1302650010556 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1302650010557 Mg++ binding site [ion binding]; other site 1302650010558 putative catalytic motif [active] 1302650010559 substrate binding site [chemical binding]; other site 1302650010560 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1302650010561 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302650010562 putative homodimer interface [polypeptide binding]; other site 1302650010563 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650010564 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650010565 active site 1302650010566 Chain length determinant protein; Region: Wzz; pfam02706 1302650010567 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1302650010568 O-Antigen ligase; Region: Wzy_C; pfam04932 1302650010569 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1302650010570 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1302650010571 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1302650010572 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1302650010573 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302650010574 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1302650010575 colanic acid exporter; Provisional; Region: PRK10459 1302650010576 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1302650010577 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1302650010578 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1302650010579 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650010580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650010581 active site 1302650010582 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1302650010583 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1302650010584 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1302650010585 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1302650010586 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1302650010587 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1302650010588 active site 1302650010589 metal binding site [ion binding]; metal-binding site 1302650010590 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1302650010591 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1302650010592 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1302650010593 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1302650010594 Stage II sporulation protein; Region: SpoIID; pfam08486 1302650010595 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1302650010596 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1302650010597 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1302650010598 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1302650010599 active site 1302650010600 homodimer interface [polypeptide binding]; other site 1302650010601 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650010602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650010603 active site 1302650010604 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1302650010605 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1302650010606 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302650010607 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1302650010608 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1302650010609 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1302650010610 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1302650010611 active site 1302650010612 tetramer interface; other site 1302650010613 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1302650010614 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1302650010615 Walker A/P-loop; other site 1302650010616 ATP binding site [chemical binding]; other site 1302650010617 Q-loop/lid; other site 1302650010618 ABC transporter signature motif; other site 1302650010619 Walker B; other site 1302650010620 D-loop; other site 1302650010621 H-loop/switch region; other site 1302650010622 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1302650010623 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1302650010624 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1302650010625 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650010626 active site 1302650010627 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650010628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650010629 active site 1302650010630 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1302650010631 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1302650010632 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1302650010633 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1302650010634 active site 1302650010635 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1302650010636 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1302650010637 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1302650010638 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1302650010639 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1302650010640 substrate binding site; other site 1302650010641 dimer interface; other site 1302650010642 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1302650010643 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1302650010644 putative NAD(P) binding site [chemical binding]; other site 1302650010645 putative catalytic Zn binding site [ion binding]; other site 1302650010646 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1302650010647 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1302650010648 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1302650010649 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1302650010650 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1302650010651 Bacterial SH3 domain; Region: SH3_3; pfam08239 1302650010652 Lysozyme subfamily 2; Region: LYZ2; smart00047 1302650010653 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1302650010654 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1302650010655 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1302650010656 Spore germination protein; Region: Spore_permease; pfam03845 1302650010657 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1302650010658 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1302650010659 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1302650010660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650010661 putative substrate translocation pore; other site 1302650010662 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1302650010663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650010664 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1302650010665 active site 1302650010666 motif I; other site 1302650010667 motif II; other site 1302650010668 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1302650010669 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1302650010670 NlpC/P60 family; Region: NLPC_P60; pfam00877 1302650010671 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1302650010672 NlpC/P60 family; Region: NLPC_P60; pfam00877 1302650010673 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1302650010674 NlpC/P60 family; Region: NLPC_P60; pfam00877 1302650010675 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1302650010676 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1302650010677 putative active site [active] 1302650010678 putative metal binding site [ion binding]; other site 1302650010679 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1302650010680 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1302650010681 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302650010682 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302650010683 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650010684 DNA binding site [nucleotide binding] 1302650010685 domain linker motif; other site 1302650010686 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1302650010687 dimerization interface [polypeptide binding]; other site 1302650010688 ligand binding site [chemical binding]; other site 1302650010689 sodium binding site [ion binding]; other site 1302650010690 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1302650010691 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1302650010692 substrate binding site [chemical binding]; other site 1302650010693 dimer interface [polypeptide binding]; other site 1302650010694 ATP binding site [chemical binding]; other site 1302650010695 D-ribose pyranase; Provisional; Region: PRK11797 1302650010696 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1302650010697 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1302650010698 Walker A/P-loop; other site 1302650010699 ATP binding site [chemical binding]; other site 1302650010700 Q-loop/lid; other site 1302650010701 ABC transporter signature motif; other site 1302650010702 Walker B; other site 1302650010703 D-loop; other site 1302650010704 H-loop/switch region; other site 1302650010705 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1302650010706 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1302650010707 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1302650010708 TM-ABC transporter signature motif; other site 1302650010709 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1302650010710 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1302650010711 ligand binding site [chemical binding]; other site 1302650010712 dimerization interface [polypeptide binding]; other site 1302650010713 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1302650010714 Bacterial SH3 domain; Region: SH3_3; cl17532 1302650010715 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1302650010716 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1302650010717 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1302650010718 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1302650010719 acetolactate synthase; Reviewed; Region: PRK08617 1302650010720 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1302650010721 PYR/PP interface [polypeptide binding]; other site 1302650010722 dimer interface [polypeptide binding]; other site 1302650010723 TPP binding site [chemical binding]; other site 1302650010724 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1302650010725 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1302650010726 TPP-binding site [chemical binding]; other site 1302650010727 dimer interface [polypeptide binding]; other site 1302650010728 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1302650010729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650010730 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1302650010731 putative dimerization interface [polypeptide binding]; other site 1302650010732 putative substrate binding pocket [chemical binding]; other site 1302650010733 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1302650010734 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1302650010735 transmembrane helices; other site 1302650010736 CotH protein; Region: CotH; pfam08757 1302650010737 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1302650010738 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1302650010739 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1302650010740 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1302650010741 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1302650010742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650010743 putative DNA binding site [nucleotide binding]; other site 1302650010744 putative Zn2+ binding site [ion binding]; other site 1302650010745 AsnC family; Region: AsnC_trans_reg; pfam01037 1302650010746 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1302650010747 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1302650010748 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1302650010749 Active_site [active] 1302650010750 potential frameshift: common BLAST hit: gi|430756663|ref|YP_007207870.1| transposase YwqJ 1302650010751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1302650010752 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1302650010753 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1302650010754 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1302650010755 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1302650010756 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1302650010757 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1302650010758 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1302650010759 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1302650010760 Chain length determinant protein; Region: Wzz; cl15801 1302650010761 SWIM zinc finger; Region: SWIM; pfam04434 1302650010762 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1302650010763 SNF2 Helicase protein; Region: DUF3670; pfam12419 1302650010764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650010765 ATP binding site [chemical binding]; other site 1302650010766 putative Mg++ binding site [ion binding]; other site 1302650010767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650010768 nucleotide binding region [chemical binding]; other site 1302650010769 ATP-binding site [chemical binding]; other site 1302650010770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650010771 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1302650010772 active site 1302650010773 motif I; other site 1302650010774 motif II; other site 1302650010775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650010776 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1302650010777 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1302650010778 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1302650010779 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1302650010780 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1302650010781 dimer interface [polypeptide binding]; other site 1302650010782 ssDNA binding site [nucleotide binding]; other site 1302650010783 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302650010784 YwpF-like protein; Region: YwpF; pfam14183 1302650010785 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1302650010786 active site 1302650010787 catalytic site [active] 1302650010788 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1302650010789 Collagen binding domain; Region: Collagen_bind; pfam05737 1302650010790 Collagen binding domain; Region: Collagen_bind; pfam05737 1302650010791 Collagen binding domain; Region: Collagen_bind; pfam05737 1302650010792 Cna protein B-type domain; Region: Cna_B; pfam05738 1302650010793 Cna protein B-type domain; Region: Cna_B; pfam05738 1302650010794 Cna protein B-type domain; Region: Cna_B; pfam05738 1302650010795 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1302650010796 Cna protein B-type domain; Region: Cna_B; pfam05738 1302650010797 Cna protein B-type domain; Region: Cna_B; pfam05738 1302650010798 Cna protein B-type domain; Region: Cna_B; pfam05738 1302650010799 Cna protein B-type domain; Region: Cna_B; pfam05738 1302650010800 Cna protein B-type domain; Region: Cna_B; pfam05738 1302650010801 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1302650010802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650010803 active site 1302650010804 phosphorylation site [posttranslational modification] 1302650010805 intermolecular recognition site; other site 1302650010806 dimerization interface [polypeptide binding]; other site 1302650010807 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1302650010808 DNA binding site [nucleotide binding] 1302650010809 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1302650010810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650010811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650010812 dimer interface [polypeptide binding]; other site 1302650010813 phosphorylation site [posttranslational modification] 1302650010814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650010815 ATP binding site [chemical binding]; other site 1302650010816 Mg2+ binding site [ion binding]; other site 1302650010817 G-X-G motif; other site 1302650010818 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1302650010819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650010820 active site 1302650010821 phosphorylation site [posttranslational modification] 1302650010822 intermolecular recognition site; other site 1302650010823 dimerization interface [polypeptide binding]; other site 1302650010824 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1302650010825 Histidine kinase; Region: His_kinase; pfam06580 1302650010826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650010827 ATP binding site [chemical binding]; other site 1302650010828 Mg2+ binding site [ion binding]; other site 1302650010829 G-X-G motif; other site 1302650010830 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1302650010831 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1302650010832 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1302650010833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650010834 binding surface 1302650010835 TPR motif; other site 1302650010836 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1302650010837 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1302650010838 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1302650010839 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1302650010840 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1302650010841 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1302650010842 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1302650010843 MreB and similar proteins; Region: MreB_like; cd10225 1302650010844 nucleotide binding site [chemical binding]; other site 1302650010845 Mg binding site [ion binding]; other site 1302650010846 putative protofilament interaction site [polypeptide binding]; other site 1302650010847 RodZ interaction site [polypeptide binding]; other site 1302650010848 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1302650010849 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650010850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650010851 putative Zn2+ binding site [ion binding]; other site 1302650010852 putative DNA binding site [nucleotide binding]; other site 1302650010853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650010854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650010855 putative substrate translocation pore; other site 1302650010856 Right handed beta helix region; Region: Beta_helix; pfam13229 1302650010857 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1302650010858 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1302650010859 Na binding site [ion binding]; other site 1302650010860 putative substrate binding site [chemical binding]; other site 1302650010861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650010862 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650010863 putative substrate translocation pore; other site 1302650010864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650010865 Isochorismatase family; Region: Isochorismatase; pfam00857 1302650010866 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1302650010867 catalytic triad [active] 1302650010868 conserved cis-peptide bond; other site 1302650010869 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1302650010870 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1302650010871 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1302650010872 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1302650010873 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1302650010874 active site 1302650010875 VanZ like family; Region: VanZ; pfam04892 1302650010876 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1302650010877 Peptidase family M23; Region: Peptidase_M23; pfam01551 1302650010878 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1302650010879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650010880 Coenzyme A binding pocket [chemical binding]; other site 1302650010881 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1302650010882 NeuB family; Region: NeuB; pfam03102 1302650010883 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1302650010884 NeuB binding interface [polypeptide binding]; other site 1302650010885 putative substrate binding site [chemical binding]; other site 1302650010886 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1302650010887 ligand binding site; other site 1302650010888 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1302650010889 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1302650010890 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1302650010891 putative active site [active] 1302650010892 catalytic site [active] 1302650010893 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1302650010894 putative active site [active] 1302650010895 catalytic site [active] 1302650010896 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1302650010897 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1302650010898 DNA binding residues [nucleotide binding] 1302650010899 dimer interface [polypeptide binding]; other site 1302650010900 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1302650010901 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1302650010902 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1302650010903 NAD binding site [chemical binding]; other site 1302650010904 substrate binding site [chemical binding]; other site 1302650010905 putative active site [active] 1302650010906 Predicted transcriptional regulator [Transcription]; Region: COG1959 1302650010907 Transcriptional regulator; Region: Rrf2; pfam02082 1302650010908 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1302650010909 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1302650010910 subunit interactions [polypeptide binding]; other site 1302650010911 active site 1302650010912 flap region; other site 1302650010913 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1302650010914 gamma-beta subunit interface [polypeptide binding]; other site 1302650010915 alpha-beta subunit interface [polypeptide binding]; other site 1302650010916 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1302650010917 alpha-gamma subunit interface [polypeptide binding]; other site 1302650010918 beta-gamma subunit interface [polypeptide binding]; other site 1302650010919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650010920 Walker B; other site 1302650010921 D-loop; other site 1302650010922 H-loop/switch region; other site 1302650010923 CsbD-like; Region: CsbD; pfam05532 1302650010924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1302650010925 binding surface 1302650010926 TPR motif; other site 1302650010927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650010928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650010929 binding surface 1302650010930 TPR motif; other site 1302650010931 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1302650010932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650010933 FeS/SAM binding site; other site 1302650010934 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1302650010935 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1302650010936 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1302650010937 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1302650010938 metal ion-dependent adhesion site (MIDAS); other site 1302650010939 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1302650010940 metal ion-dependent adhesion site (MIDAS); other site 1302650010941 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1302650010942 Stage II sporulation protein; Region: SpoIID; pfam08486 1302650010943 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1302650010944 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1302650010945 hinge; other site 1302650010946 active site 1302650010947 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1302650010948 Predicted membrane protein [Function unknown]; Region: COG4836 1302650010949 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1302650010950 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1302650010951 gamma subunit interface [polypeptide binding]; other site 1302650010952 epsilon subunit interface [polypeptide binding]; other site 1302650010953 LBP interface [polypeptide binding]; other site 1302650010954 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1302650010955 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1302650010956 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1302650010957 alpha subunit interaction interface [polypeptide binding]; other site 1302650010958 Walker A motif; other site 1302650010959 ATP binding site [chemical binding]; other site 1302650010960 Walker B motif; other site 1302650010961 inhibitor binding site; inhibition site 1302650010962 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1302650010963 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1302650010964 core domain interface [polypeptide binding]; other site 1302650010965 delta subunit interface [polypeptide binding]; other site 1302650010966 epsilon subunit interface [polypeptide binding]; other site 1302650010967 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1302650010968 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1302650010969 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1302650010970 beta subunit interaction interface [polypeptide binding]; other site 1302650010971 Walker A motif; other site 1302650010972 ATP binding site [chemical binding]; other site 1302650010973 Walker B motif; other site 1302650010974 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1302650010975 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1302650010976 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1302650010977 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1302650010978 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1302650010979 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1302650010980 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1302650010981 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1302650010982 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1302650010983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302650010984 active site 1302650010985 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1302650010986 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1302650010987 dimer interface [polypeptide binding]; other site 1302650010988 active site 1302650010989 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1302650010990 folate binding site [chemical binding]; other site 1302650010991 hypothetical protein; Provisional; Region: PRK13690 1302650010992 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1302650010993 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1302650010994 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1302650010995 active site 1302650010996 Predicted membrane protein [Function unknown]; Region: COG1971 1302650010997 Domain of unknown function DUF; Region: DUF204; pfam02659 1302650010998 Domain of unknown function DUF; Region: DUF204; pfam02659 1302650010999 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1302650011000 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1302650011001 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 1302650011002 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1302650011003 HemK family putative methylases; Region: hemK_fam; TIGR00536 1302650011004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650011005 S-adenosylmethionine binding site [chemical binding]; other site 1302650011006 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1302650011007 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1302650011008 RF-1 domain; Region: RF-1; pfam00472 1302650011009 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1302650011010 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650011011 putative metal binding site [ion binding]; other site 1302650011012 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1302650011013 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1302650011014 DNA binding residues [nucleotide binding] 1302650011015 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1302650011016 malate dehydrogenase; Provisional; Region: PRK13529 1302650011017 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1302650011018 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1302650011019 NAD(P) binding site [chemical binding]; other site 1302650011020 thymidine kinase; Provisional; Region: PRK04296 1302650011021 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1302650011022 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1302650011023 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1302650011024 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1302650011025 RNA binding site [nucleotide binding]; other site 1302650011026 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1302650011027 multimer interface [polypeptide binding]; other site 1302650011028 Walker A motif; other site 1302650011029 ATP binding site [chemical binding]; other site 1302650011030 Walker B motif; other site 1302650011031 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1302650011032 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1302650011033 putative active site [active] 1302650011034 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1302650011035 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1302650011036 hinge; other site 1302650011037 active site 1302650011038 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1302650011039 active site 1302650011040 intersubunit interactions; other site 1302650011041 catalytic residue [active] 1302650011042 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1302650011043 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1302650011044 intersubunit interface [polypeptide binding]; other site 1302650011045 active site 1302650011046 zinc binding site [ion binding]; other site 1302650011047 Na+ binding site [ion binding]; other site 1302650011048 Response regulator receiver domain; Region: Response_reg; pfam00072 1302650011049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650011050 active site 1302650011051 phosphorylation site [posttranslational modification] 1302650011052 intermolecular recognition site; other site 1302650011053 dimerization interface [polypeptide binding]; other site 1302650011054 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1302650011055 CTP synthetase; Validated; Region: pyrG; PRK05380 1302650011056 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1302650011057 Catalytic site [active] 1302650011058 active site 1302650011059 UTP binding site [chemical binding]; other site 1302650011060 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1302650011061 active site 1302650011062 putative oxyanion hole; other site 1302650011063 catalytic triad [active] 1302650011064 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1302650011065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1302650011066 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1302650011067 FAD binding site [chemical binding]; other site 1302650011068 homotetramer interface [polypeptide binding]; other site 1302650011069 substrate binding pocket [chemical binding]; other site 1302650011070 catalytic base [active] 1302650011071 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1302650011072 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1302650011073 Cysteine-rich domain; Region: CCG; pfam02754 1302650011074 Cysteine-rich domain; Region: CCG; pfam02754 1302650011075 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1302650011076 putative active site [active] 1302650011077 catalytic site [active] 1302650011078 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1302650011079 PLD-like domain; Region: PLDc_2; pfam13091 1302650011080 putative active site [active] 1302650011081 catalytic site [active] 1302650011082 UV-endonuclease UvdE; Region: UvdE; cl10036 1302650011083 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1302650011084 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1302650011085 folate binding site [chemical binding]; other site 1302650011086 NADP+ binding site [chemical binding]; other site 1302650011087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302650011088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650011089 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1302650011090 Walker A/P-loop; other site 1302650011091 ATP binding site [chemical binding]; other site 1302650011092 Q-loop/lid; other site 1302650011093 ABC transporter signature motif; other site 1302650011094 Walker B; other site 1302650011095 D-loop; other site 1302650011096 H-loop/switch region; other site 1302650011097 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1302650011098 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1302650011099 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1302650011100 putative active site [active] 1302650011101 catalytic site [active] 1302650011102 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1302650011103 putative active site [active] 1302650011104 catalytic site [active] 1302650011105 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1302650011106 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1302650011107 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1302650011108 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1302650011109 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1302650011110 [4Fe-4S] binding site [ion binding]; other site 1302650011111 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1302650011112 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1302650011113 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1302650011114 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1302650011115 molybdopterin cofactor binding site; other site 1302650011116 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1302650011117 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1302650011118 ligand binding site [chemical binding]; other site 1302650011119 flexible hinge region; other site 1302650011120 YwiC-like protein; Region: YwiC; pfam14256 1302650011121 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1302650011122 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1302650011123 ligand binding site [chemical binding]; other site 1302650011124 flexible hinge region; other site 1302650011125 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1302650011126 putative switch regulator; other site 1302650011127 non-specific DNA interactions [nucleotide binding]; other site 1302650011128 DNA binding site [nucleotide binding] 1302650011129 sequence specific DNA binding site [nucleotide binding]; other site 1302650011130 putative cAMP binding site [chemical binding]; other site 1302650011131 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1302650011132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650011133 putative substrate translocation pore; other site 1302650011134 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1302650011135 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1302650011136 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1302650011137 active site 1302650011138 HIGH motif; other site 1302650011139 KMSK motif region; other site 1302650011140 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1302650011141 tRNA binding surface [nucleotide binding]; other site 1302650011142 anticodon binding site; other site 1302650011143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1302650011144 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 1302650011145 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1302650011146 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1302650011147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302650011148 FeS/SAM binding site; other site 1302650011149 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1302650011150 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1302650011151 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302650011152 Walker A/P-loop; other site 1302650011153 ATP binding site [chemical binding]; other site 1302650011154 Q-loop/lid; other site 1302650011155 ABC transporter signature motif; other site 1302650011156 Walker B; other site 1302650011157 D-loop; other site 1302650011158 H-loop/switch region; other site 1302650011159 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1302650011160 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1302650011161 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1302650011162 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1302650011163 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1302650011164 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1302650011165 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1302650011166 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1302650011167 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1302650011168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1302650011169 binding surface 1302650011170 TPR motif; other site 1302650011171 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1302650011172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650011173 TPR motif; other site 1302650011174 binding surface 1302650011175 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650011176 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1302650011177 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1302650011178 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302650011179 Walker A/P-loop; other site 1302650011180 ATP binding site [chemical binding]; other site 1302650011181 Q-loop/lid; other site 1302650011182 ABC transporter signature motif; other site 1302650011183 Walker B; other site 1302650011184 D-loop; other site 1302650011185 H-loop/switch region; other site 1302650011186 agmatinase; Region: agmatinase; TIGR01230 1302650011187 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1302650011188 putative active site [active] 1302650011189 Mn binding site [ion binding]; other site 1302650011190 spermidine synthase; Provisional; Region: PRK00811 1302650011191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650011192 Transglycosylase; Region: Transgly; pfam00912 1302650011193 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1302650011194 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1302650011195 YwhD family; Region: YwhD; pfam08741 1302650011196 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1302650011197 Peptidase family M50; Region: Peptidase_M50; pfam02163 1302650011198 active site 1302650011199 putative substrate binding region [chemical binding]; other site 1302650011200 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1302650011201 active site 1 [active] 1302650011202 dimer interface [polypeptide binding]; other site 1302650011203 hexamer interface [polypeptide binding]; other site 1302650011204 active site 2 [active] 1302650011205 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650011206 MarR family; Region: MarR; pfam01047 1302650011207 MarR family; Region: MarR_2; cl17246 1302650011208 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1302650011209 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1302650011210 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1302650011211 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1302650011212 active site 1302650011213 dimer interface [polypeptide binding]; other site 1302650011214 motif 1; other site 1302650011215 motif 2; other site 1302650011216 motif 3; other site 1302650011217 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1302650011218 anticodon binding site; other site 1302650011219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650011220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650011221 putative substrate translocation pore; other site 1302650011222 Rrf2 family protein; Region: rrf2_super; TIGR00738 1302650011223 Transcriptional regulator; Region: Rrf2; pfam02082 1302650011224 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1302650011225 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1302650011226 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302650011227 Zn2+ binding site [ion binding]; other site 1302650011228 Mg2+ binding site [ion binding]; other site 1302650011229 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1302650011230 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1302650011231 EamA-like transporter family; Region: EamA; pfam00892 1302650011232 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1302650011233 EamA-like transporter family; Region: EamA; pfam00892 1302650011234 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1302650011235 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650011236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650011237 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1302650011238 putative dimerization interface [polypeptide binding]; other site 1302650011239 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1302650011240 putative heme peroxidase; Provisional; Region: PRK12276 1302650011241 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1302650011242 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1302650011243 putative NAD(P) binding site [chemical binding]; other site 1302650011244 putative active site [active] 1302650011245 transaminase; Reviewed; Region: PRK08068 1302650011246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302650011247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650011248 homodimer interface [polypeptide binding]; other site 1302650011249 catalytic residue [active] 1302650011250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1302650011251 H+ Antiporter protein; Region: 2A0121; TIGR00900 1302650011252 putative substrate translocation pore; other site 1302650011253 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1302650011254 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1302650011255 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1302650011256 classical (c) SDRs; Region: SDR_c; cd05233 1302650011257 NAD(P) binding site [chemical binding]; other site 1302650011258 active site 1302650011259 Cupin domain; Region: Cupin_2; pfam07883 1302650011260 Cupin domain; Region: Cupin_2; pfam07883 1302650011261 Prephenate dehydratase; Region: PDT; pfam00800 1302650011262 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1302650011263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650011264 putative substrate translocation pore; other site 1302650011265 S-methylmethionine transporter; Provisional; Region: PRK11387 1302650011266 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1302650011267 putative metal binding site [ion binding]; other site 1302650011268 putative dimer interface [polypeptide binding]; other site 1302650011269 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1302650011270 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1302650011271 Glutamate binding site [chemical binding]; other site 1302650011272 homodimer interface [polypeptide binding]; other site 1302650011273 NAD binding site [chemical binding]; other site 1302650011274 catalytic residues [active] 1302650011275 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1302650011276 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1302650011277 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1302650011278 NAD(P) binding site [chemical binding]; other site 1302650011279 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1302650011280 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1302650011281 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1302650011282 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1302650011283 NADP binding site [chemical binding]; other site 1302650011284 active site 1302650011285 putative substrate binding site [chemical binding]; other site 1302650011286 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1302650011287 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1302650011288 NAD binding site [chemical binding]; other site 1302650011289 substrate binding site [chemical binding]; other site 1302650011290 homodimer interface [polypeptide binding]; other site 1302650011291 active site 1302650011292 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1302650011293 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1302650011294 substrate binding site; other site 1302650011295 tetramer interface; other site 1302650011296 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1302650011297 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1302650011298 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1302650011299 ligand binding site; other site 1302650011300 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1302650011301 NeuB family; Region: NeuB; pfam03102 1302650011302 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1302650011303 NeuB binding interface [polypeptide binding]; other site 1302650011304 putative substrate binding site [chemical binding]; other site 1302650011305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302650011306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650011307 Coenzyme A binding pocket [chemical binding]; other site 1302650011308 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1302650011309 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1302650011310 inhibitor-cofactor binding pocket; inhibition site 1302650011311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650011312 catalytic residue [active] 1302650011313 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1302650011314 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1302650011315 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650011316 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650011317 active site 1302650011318 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1302650011319 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1302650011320 Permease family; Region: Xan_ur_permease; pfam00860 1302650011321 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1302650011322 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1302650011323 NAD(P) binding site [chemical binding]; other site 1302650011324 catalytic residues [active] 1302650011325 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1302650011326 ligand binding site [chemical binding]; other site 1302650011327 active site 1302650011328 UGI interface [polypeptide binding]; other site 1302650011329 catalytic site [active] 1302650011330 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302650011331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302650011332 active site 1302650011333 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1302650011334 dimer interface [polypeptide binding]; other site 1302650011335 substrate binding site [chemical binding]; other site 1302650011336 ATP binding site [chemical binding]; other site 1302650011337 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1302650011338 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1302650011339 substrate binding [chemical binding]; other site 1302650011340 active site 1302650011341 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1302650011342 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1302650011343 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302650011344 active site turn [active] 1302650011345 phosphorylation site [posttranslational modification] 1302650011346 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302650011347 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1302650011348 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1302650011349 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1302650011350 CAT RNA binding domain; Region: CAT_RBD; smart01061 1302650011351 PRD domain; Region: PRD; pfam00874 1302650011352 PRD domain; Region: PRD; pfam00874 1302650011353 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1302650011354 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1302650011355 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1302650011356 putative active site [active] 1302650011357 catalytic triad [active] 1302650011358 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1302650011359 PA/protease domain interface [polypeptide binding]; other site 1302650011360 putative integrin binding motif; other site 1302650011361 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1302650011362 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1302650011363 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1302650011364 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1302650011365 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1302650011366 dimer interface [polypeptide binding]; other site 1302650011367 FMN binding site [chemical binding]; other site 1302650011368 NADPH bind site [chemical binding]; other site 1302650011369 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1302650011370 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1302650011371 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1302650011372 Subunit I/III interface [polypeptide binding]; other site 1302650011373 Subunit III/IV interface [polypeptide binding]; other site 1302650011374 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1302650011375 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1302650011376 D-pathway; other site 1302650011377 Putative ubiquinol binding site [chemical binding]; other site 1302650011378 Low-spin heme (heme b) binding site [chemical binding]; other site 1302650011379 Putative water exit pathway; other site 1302650011380 Binuclear center (heme o3/CuB) [ion binding]; other site 1302650011381 K-pathway; other site 1302650011382 Putative proton exit pathway; other site 1302650011383 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1302650011384 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1302650011385 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1302650011386 Predicted membrane protein [Function unknown]; Region: COG2261 1302650011387 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 1302650011388 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1302650011389 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1302650011390 galactokinase; Provisional; Region: PRK05322 1302650011391 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1302650011392 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1302650011393 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1302650011394 Predicted membrane protein [Function unknown]; Region: COG2246 1302650011395 GtrA-like protein; Region: GtrA; pfam04138 1302650011396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650011397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650011398 Anti-repressor SinI; Region: SinI; pfam08671 1302650011399 Predicted membrane protein [Function unknown]; Region: COG3162 1302650011400 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1302650011401 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1302650011402 Na binding site [ion binding]; other site 1302650011403 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1302650011404 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1302650011405 catalytic residues [active] 1302650011406 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1302650011407 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1302650011408 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1302650011409 Imelysin; Region: Peptidase_M75; pfam09375 1302650011410 FTR1 family protein; Region: TIGR00145 1302650011411 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1302650011412 thiamine phosphate binding site [chemical binding]; other site 1302650011413 active site 1302650011414 pyrophosphate binding site [ion binding]; other site 1302650011415 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1302650011416 substrate binding site [chemical binding]; other site 1302650011417 multimerization interface [polypeptide binding]; other site 1302650011418 ATP binding site [chemical binding]; other site 1302650011419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650011420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650011421 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1302650011422 putative dimerization interface [polypeptide binding]; other site 1302650011423 holin-like protein; Validated; Region: PRK01658 1302650011424 TIGR00659 family protein; Region: TIGR00659 1302650011425 sugar efflux transporter; Region: 2A0120; TIGR00899 1302650011426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650011427 putative substrate translocation pore; other site 1302650011428 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1302650011429 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1302650011430 PUA domain; Region: PUA; cl00607 1302650011431 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1302650011432 putative RNA binding site [nucleotide binding]; other site 1302650011433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650011434 S-adenosylmethionine binding site [chemical binding]; other site 1302650011435 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650011436 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1302650011437 active site 1302650011438 metal binding site [ion binding]; metal-binding site 1302650011439 potential frameshift: common BLAST hit: gi|402778002|ref|YP_006631946.1| protein YwbB 1302650011440 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1302650011441 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1302650011442 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1302650011443 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1302650011444 active site 1302650011445 catalytic residues [active] 1302650011446 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1302650011447 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302650011448 active site turn [active] 1302650011449 phosphorylation site [posttranslational modification] 1302650011450 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302650011451 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1302650011452 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1302650011453 PRD domain; Region: PRD; pfam00874 1302650011454 PRD domain; Region: PRD; pfam00874 1302650011455 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1302650011456 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1302650011457 Ligand binding site; other site 1302650011458 metal-binding site 1302650011459 Predicted integral membrane protein [Function unknown]; Region: COG5522 1302650011460 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650011461 MarR family; Region: MarR; pfam01047 1302650011462 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1302650011463 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1302650011464 active site 1302650011465 HIGH motif; other site 1302650011466 dimer interface [polypeptide binding]; other site 1302650011467 KMSKS motif; other site 1302650011468 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302650011469 RNA binding surface [nucleotide binding]; other site 1302650011470 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1302650011471 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1302650011472 PA/protease domain interface [polypeptide binding]; other site 1302650011473 putative integrin binding motif; other site 1302650011474 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1302650011475 Peptidase family M28; Region: Peptidase_M28; pfam04389 1302650011476 metal binding site [ion binding]; metal-binding site 1302650011477 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1302650011478 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1302650011479 synthetase active site [active] 1302650011480 NTP binding site [chemical binding]; other site 1302650011481 metal binding site [ion binding]; metal-binding site 1302650011482 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1302650011483 UbiA prenyltransferase family; Region: UbiA; pfam01040 1302650011484 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1302650011485 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1302650011486 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1302650011487 acyl-activating enzyme (AAE) consensus motif; other site 1302650011488 AMP binding site [chemical binding]; other site 1302650011489 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1302650011490 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1302650011491 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1302650011492 DltD N-terminal region; Region: DltD_N; pfam04915 1302650011493 DltD central region; Region: DltD_M; pfam04918 1302650011494 DltD C-terminal region; Region: DltD_C; pfam04914 1302650011495 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1302650011496 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1302650011497 putative NAD(P) binding site [chemical binding]; other site 1302650011498 active site 1302650011499 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1302650011500 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1302650011501 homodimer interface [polypeptide binding]; other site 1302650011502 substrate-cofactor binding pocket; other site 1302650011503 catalytic residue [active] 1302650011504 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1302650011505 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1302650011506 NAD binding site [chemical binding]; other site 1302650011507 sugar binding site [chemical binding]; other site 1302650011508 divalent metal binding site [ion binding]; other site 1302650011509 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302650011510 dimer interface [polypeptide binding]; other site 1302650011511 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1302650011512 methionine cluster; other site 1302650011513 active site 1302650011514 phosphorylation site [posttranslational modification] 1302650011515 metal binding site [ion binding]; metal-binding site 1302650011516 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1302650011517 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1302650011518 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1302650011519 active site 1302650011520 P-loop; other site 1302650011521 phosphorylation site [posttranslational modification] 1302650011522 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1302650011523 HTH domain; Region: HTH_11; pfam08279 1302650011524 Mga helix-turn-helix domain; Region: Mga; pfam05043 1302650011525 PRD domain; Region: PRD; pfam00874 1302650011526 PRD domain; Region: PRD; pfam00874 1302650011527 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1302650011528 active site 1302650011529 P-loop; other site 1302650011530 phosphorylation site [posttranslational modification] 1302650011531 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1302650011532 active site 1302650011533 phosphorylation site [posttranslational modification] 1302650011534 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1302650011535 active site 1302650011536 DNA binding site [nucleotide binding] 1302650011537 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1302650011538 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1302650011539 tetramer interface [polypeptide binding]; other site 1302650011540 heme binding pocket [chemical binding]; other site 1302650011541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650011542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650011543 putative substrate translocation pore; other site 1302650011544 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1302650011545 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302650011546 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302650011547 Walker A/P-loop; other site 1302650011548 ATP binding site [chemical binding]; other site 1302650011549 Q-loop/lid; other site 1302650011550 ABC transporter signature motif; other site 1302650011551 Walker B; other site 1302650011552 D-loop; other site 1302650011553 H-loop/switch region; other site 1302650011554 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1302650011555 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1302650011556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302650011557 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302650011558 DNA binding residues [nucleotide binding] 1302650011559 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1302650011560 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1302650011561 Na binding site [ion binding]; other site 1302650011562 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1302650011563 putative substrate binding site [chemical binding]; other site 1302650011564 putative ATP binding site [chemical binding]; other site 1302650011565 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1302650011566 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650011567 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1302650011568 Walker A/P-loop; other site 1302650011569 ATP binding site [chemical binding]; other site 1302650011570 Q-loop/lid; other site 1302650011571 ABC transporter signature motif; other site 1302650011572 Walker B; other site 1302650011573 D-loop; other site 1302650011574 H-loop/switch region; other site 1302650011575 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1302650011576 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302650011577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650011578 ATP binding site [chemical binding]; other site 1302650011579 Q-loop/lid; other site 1302650011580 ABC transporter signature motif; other site 1302650011581 Walker B; other site 1302650011582 D-loop; other site 1302650011583 H-loop/switch region; other site 1302650011584 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1302650011585 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1302650011586 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1302650011587 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1302650011588 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1302650011589 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1302650011590 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1302650011591 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1302650011592 putative active site [active] 1302650011593 putative metal binding site [ion binding]; other site 1302650011594 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1302650011595 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1302650011596 Walker A/P-loop; other site 1302650011597 ATP binding site [chemical binding]; other site 1302650011598 Q-loop/lid; other site 1302650011599 ABC transporter signature motif; other site 1302650011600 Walker B; other site 1302650011601 D-loop; other site 1302650011602 H-loop/switch region; other site 1302650011603 TOBE domain; Region: TOBE; pfam03459 1302650011604 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1302650011605 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1302650011606 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1302650011607 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1302650011608 NAD(P) binding site [chemical binding]; other site 1302650011609 catalytic residues [active] 1302650011610 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1302650011611 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650011612 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302650011613 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1302650011614 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1302650011615 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1302650011616 UDP-glucose 4-epimerase; Region: PLN02240 1302650011617 NAD binding site [chemical binding]; other site 1302650011618 homodimer interface [polypeptide binding]; other site 1302650011619 active site 1302650011620 substrate binding site [chemical binding]; other site 1302650011621 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1302650011622 substrate binding site [chemical binding]; other site 1302650011623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650011624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650011625 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302650011626 dimerization interface [polypeptide binding]; other site 1302650011627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302650011628 Histidine kinase; Region: HisKA_3; pfam07730 1302650011629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650011630 ATP binding site [chemical binding]; other site 1302650011631 Mg2+ binding site [ion binding]; other site 1302650011632 G-X-G motif; other site 1302650011633 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302650011634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650011635 active site 1302650011636 phosphorylation site [posttranslational modification] 1302650011637 intermolecular recognition site; other site 1302650011638 dimerization interface [polypeptide binding]; other site 1302650011639 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302650011640 DNA binding residues [nucleotide binding] 1302650011641 dimerization interface [polypeptide binding]; other site 1302650011642 peptidase T; Region: peptidase-T; TIGR01882 1302650011643 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1302650011644 metal binding site [ion binding]; metal-binding site 1302650011645 dimer interface [polypeptide binding]; other site 1302650011646 Tubby C 2; Region: Tub_2; cl02043 1302650011647 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1302650011648 substrate binding site [chemical binding]; other site 1302650011649 THF binding site; other site 1302650011650 zinc-binding site [ion binding]; other site 1302650011651 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1302650011652 substrate binding site [chemical binding]; other site 1302650011653 THF binding site; other site 1302650011654 zinc-binding site [ion binding]; other site 1302650011655 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1302650011656 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1302650011657 NAD binding site [chemical binding]; other site 1302650011658 homotetramer interface [polypeptide binding]; other site 1302650011659 homodimer interface [polypeptide binding]; other site 1302650011660 substrate binding site [chemical binding]; other site 1302650011661 active site 1302650011662 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1302650011663 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1302650011664 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1302650011665 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1302650011666 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1302650011667 S-adenosylmethionine binding site [chemical binding]; other site 1302650011668 nucleoside transporter; Region: nupC; TIGR00804 1302650011669 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1302650011670 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1302650011671 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1302650011672 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1302650011673 hydroperoxidase II; Provisional; Region: katE; PRK11249 1302650011674 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1302650011675 tetramer interface [polypeptide binding]; other site 1302650011676 heme binding pocket [chemical binding]; other site 1302650011677 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1302650011678 domain interactions; other site 1302650011679 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1302650011680 Citrate transporter; Region: CitMHS; pfam03600 1302650011681 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1302650011682 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1302650011683 active site 1302650011684 active site 1302650011685 catalytic residues [active] 1302650011686 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1302650011687 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1302650011688 PRD domain; Region: PRD; pfam00874 1302650011689 PRD domain; Region: PRD; pfam00874 1302650011690 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1302650011691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650011692 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1302650011693 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1302650011694 ATP binding site [chemical binding]; other site 1302650011695 Mg++ binding site [ion binding]; other site 1302650011696 motif III; other site 1302650011697 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650011698 nucleotide binding region [chemical binding]; other site 1302650011699 ATP-binding site [chemical binding]; other site 1302650011700 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1302650011701 RNA binding site [nucleotide binding]; other site 1302650011702 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1302650011703 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1302650011704 active site 1302650011705 catalytic triad [active] 1302650011706 RHS Repeat; Region: RHS_repeat; pfam05593 1302650011707 RHS Repeat; Region: RHS_repeat; pfam05593 1302650011708 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1302650011709 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1302650011710 RHS Repeat; Region: RHS_repeat; pfam05593 1302650011711 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1302650011712 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1302650011713 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1302650011714 EamA-like transporter family; Region: EamA; pfam00892 1302650011715 EamA-like transporter family; Region: EamA; pfam00892 1302650011716 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1302650011717 Ligand Binding Site [chemical binding]; other site 1302650011718 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1302650011719 beta-galactosidase; Region: BGL; TIGR03356 1302650011720 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1302650011721 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302650011722 active site turn [active] 1302650011723 phosphorylation site [posttranslational modification] 1302650011724 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302650011725 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1302650011726 HPr interaction site; other site 1302650011727 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1302650011728 active site 1302650011729 phosphorylation site [posttranslational modification] 1302650011730 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 1302650011731 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 1302650011732 LXG domain of WXG superfamily; Region: LXG; pfam04740 1302650011733 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1302650011734 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 1302650011735 PLD-like domain; Region: PLDc_2; pfam13091 1302650011736 putative homodimer interface [polypeptide binding]; other site 1302650011737 putative active site [active] 1302650011738 catalytic site [active] 1302650011739 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1302650011740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650011741 ATP binding site [chemical binding]; other site 1302650011742 putative Mg++ binding site [ion binding]; other site 1302650011743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302650011744 nucleotide binding region [chemical binding]; other site 1302650011745 ATP-binding site [chemical binding]; other site 1302650011746 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1302650011747 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1302650011748 active site 1302650011749 8-oxo-dGMP binding site [chemical binding]; other site 1302650011750 nudix motif; other site 1302650011751 metal binding site [ion binding]; metal-binding site 1302650011752 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1302650011753 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1302650011754 substrate binding site [chemical binding]; other site 1302650011755 active site 1302650011756 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1302650011757 hexamer interface [polypeptide binding]; other site 1302650011758 RNA binding site [nucleotide binding]; other site 1302650011759 Histidine-zinc binding site [chemical binding]; other site 1302650011760 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1302650011761 active sites [active] 1302650011762 tetramer interface [polypeptide binding]; other site 1302650011763 urocanate hydratase; Provisional; Region: PRK05414 1302650011764 imidazolonepropionase; Validated; Region: PRK09356 1302650011765 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1302650011766 active site 1302650011767 Agmatinase-like family; Region: Agmatinase-like; cd09990 1302650011768 agmatinase; Region: agmatinase; TIGR01230 1302650011769 active site 1302650011770 oligomer interface [polypeptide binding]; other site 1302650011771 Mn binding site [ion binding]; other site 1302650011772 S-methylmethionine transporter; Provisional; Region: PRK11387 1302650011773 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1302650011774 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1302650011775 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1302650011776 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1302650011777 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1302650011778 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1302650011779 Nucleoside recognition; Region: Gate; pfam07670 1302650011780 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1302650011781 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1302650011782 intersubunit interface [polypeptide binding]; other site 1302650011783 active site 1302650011784 catalytic residue [active] 1302650011785 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1302650011786 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1302650011787 DNA binding residues [nucleotide binding] 1302650011788 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1302650011789 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1302650011790 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1302650011791 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1302650011792 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1302650011793 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 1302650011794 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1302650011795 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1302650011796 metal binding site [ion binding]; metal-binding site 1302650011797 dimer interface [polypeptide binding]; other site 1302650011798 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302650011799 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1302650011800 Walker A/P-loop; other site 1302650011801 ATP binding site [chemical binding]; other site 1302650011802 Q-loop/lid; other site 1302650011803 ABC transporter signature motif; other site 1302650011804 Walker B; other site 1302650011805 D-loop; other site 1302650011806 H-loop/switch region; other site 1302650011807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302650011808 dimer interface [polypeptide binding]; other site 1302650011809 conserved gate region; other site 1302650011810 putative PBP binding loops; other site 1302650011811 ABC-ATPase subunit interface; other site 1302650011812 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302650011813 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302650011814 substrate binding pocket [chemical binding]; other site 1302650011815 membrane-bound complex binding site; other site 1302650011816 hinge residues; other site 1302650011817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650011818 Coenzyme A binding pocket [chemical binding]; other site 1302650011819 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1302650011820 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1302650011821 active site 1302650011822 non-prolyl cis peptide bond; other site 1302650011823 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1302650011824 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1302650011825 active site 1302650011826 sugar phosphate phosphatase; Provisional; Region: PRK10513 1302650011827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650011828 active site 1302650011829 motif I; other site 1302650011830 motif II; other site 1302650011831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302650011832 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1302650011833 proteasome-activating nucleotidase; Provisional; Region: PRK03992 1302650011834 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1302650011835 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1302650011836 putative ligand binding residues [chemical binding]; other site 1302650011837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1302650011838 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302650011839 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302650011840 Walker A/P-loop; other site 1302650011841 ATP binding site [chemical binding]; other site 1302650011842 Q-loop/lid; other site 1302650011843 ABC transporter signature motif; other site 1302650011844 Walker B; other site 1302650011845 D-loop; other site 1302650011846 H-loop/switch region; other site 1302650011847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302650011848 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1302650011849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650011850 ATP binding site [chemical binding]; other site 1302650011851 Mg2+ binding site [ion binding]; other site 1302650011852 G-X-G motif; other site 1302650011853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650011854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650011855 active site 1302650011856 phosphorylation site [posttranslational modification] 1302650011857 intermolecular recognition site; other site 1302650011858 dimerization interface [polypeptide binding]; other site 1302650011859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650011860 DNA binding site [nucleotide binding] 1302650011861 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1302650011862 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1302650011863 intersubunit interface [polypeptide binding]; other site 1302650011864 active site 1302650011865 zinc binding site [ion binding]; other site 1302650011866 Na+ binding site [ion binding]; other site 1302650011867 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1302650011868 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1302650011869 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1302650011870 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1302650011871 DNA interaction; other site 1302650011872 Metal-binding active site; metal-binding site 1302650011873 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1302650011874 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1302650011875 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1302650011876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650011877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650011878 putative substrate translocation pore; other site 1302650011879 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1302650011880 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1302650011881 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1302650011882 PYR/PP interface [polypeptide binding]; other site 1302650011883 dimer interface [polypeptide binding]; other site 1302650011884 TPP binding site [chemical binding]; other site 1302650011885 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1302650011886 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1302650011887 TPP-binding site; other site 1302650011888 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1302650011889 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1302650011890 substrate binding site [chemical binding]; other site 1302650011891 ATP binding site [chemical binding]; other site 1302650011892 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1302650011893 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1302650011894 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1302650011895 tetrameric interface [polypeptide binding]; other site 1302650011896 NAD binding site [chemical binding]; other site 1302650011897 catalytic residues [active] 1302650011898 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1302650011899 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1302650011900 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1302650011901 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302650011902 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302650011903 active site 1302650011904 catalytic tetrad [active] 1302650011905 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1302650011906 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1302650011907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650011908 putative substrate translocation pore; other site 1302650011909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650011910 heat shock protein 90; Provisional; Region: PRK05218 1302650011911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650011912 ATP binding site [chemical binding]; other site 1302650011913 Mg2+ binding site [ion binding]; other site 1302650011914 G-X-G motif; other site 1302650011915 short chain dehydrogenase; Validated; Region: PRK08589 1302650011916 classical (c) SDRs; Region: SDR_c; cd05233 1302650011917 NAD(P) binding site [chemical binding]; other site 1302650011918 active site 1302650011919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650011920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650011921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650011922 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1302650011923 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1302650011924 NAD(P) binding site [chemical binding]; other site 1302650011925 catalytic residues [active] 1302650011926 RDD family; Region: RDD; pfam06271 1302650011927 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1302650011928 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1302650011929 active site 1302650011930 Trp docking motif [polypeptide binding]; other site 1302650011931 RDD family; Region: RDD; pfam06271 1302650011932 Predicted membrane protein [Function unknown]; Region: COG2311 1302650011933 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1302650011934 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1302650011935 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1302650011936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302650011937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302650011938 short chain dehydrogenase; Provisional; Region: PRK07109 1302650011939 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1302650011940 putative NAD(P) binding site [chemical binding]; other site 1302650011941 active site 1302650011942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650011943 MarR family; Region: MarR; pfam01047 1302650011944 LrgA family; Region: LrgA; cl00608 1302650011945 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1302650011946 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1302650011947 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1302650011948 Glycerate kinase family; Region: Gly_kinase; pfam02595 1302650011949 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1302650011950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650011951 DNA-binding site [nucleotide binding]; DNA binding site 1302650011952 FCD domain; Region: FCD; pfam07729 1302650011953 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1302650011954 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1302650011955 N- and C-terminal domain interface [polypeptide binding]; other site 1302650011956 active site 1302650011957 catalytic site [active] 1302650011958 metal binding site [ion binding]; metal-binding site 1302650011959 carbohydrate binding site [chemical binding]; other site 1302650011960 ATP binding site [chemical binding]; other site 1302650011961 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1302650011962 gluconate transporter; Region: gntP; TIGR00791 1302650011963 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 1302650011964 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1302650011965 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1302650011966 peroxiredoxin; Region: AhpC; TIGR03137 1302650011967 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1302650011968 dimer interface [polypeptide binding]; other site 1302650011969 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1302650011970 catalytic triad [active] 1302650011971 peroxidatic and resolving cysteines [active] 1302650011972 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1302650011973 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1302650011974 catalytic residue [active] 1302650011975 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1302650011976 catalytic residues [active] 1302650011977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1302650011978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302650011979 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1302650011980 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1302650011981 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1302650011982 beta-galactosidase; Region: BGL; TIGR03356 1302650011983 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1302650011984 active site turn [active] 1302650011985 phosphorylation site [posttranslational modification] 1302650011986 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1302650011987 HPr interaction site; other site 1302650011988 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1302650011989 active site 1302650011990 phosphorylation site [posttranslational modification] 1302650011991 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1302650011992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302650011993 DNA-binding site [nucleotide binding]; DNA binding site 1302650011994 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1302650011995 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1302650011996 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1302650011997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302650011998 Walker A/P-loop; other site 1302650011999 ATP binding site [chemical binding]; other site 1302650012000 ABC transporter signature motif; other site 1302650012001 Walker B; other site 1302650012002 D-loop; other site 1302650012003 H-loop/switch region; other site 1302650012004 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1302650012005 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1302650012006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302650012007 ATP binding site [chemical binding]; other site 1302650012008 putative Mg++ binding site [ion binding]; other site 1302650012009 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1302650012010 DNA methylase; Region: N6_N4_Mtase; pfam01555 1302650012011 DNA methylase; Region: N6_N4_Mtase; cl17433 1302650012012 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1302650012013 Part of AAA domain; Region: AAA_19; pfam13245 1302650012014 Family description; Region: UvrD_C_2; pfam13538 1302650012015 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1302650012016 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1302650012017 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1302650012018 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1302650012019 NAD binding site [chemical binding]; other site 1302650012020 catalytic Zn binding site [ion binding]; other site 1302650012021 structural Zn binding site [ion binding]; other site 1302650012022 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1302650012023 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1302650012024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302650012025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650012026 Coenzyme A binding pocket [chemical binding]; other site 1302650012027 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650012028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302650012029 binding surface 1302650012030 TPR motif; other site 1302650012031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302650012032 Arginase family; Region: Arginase; cd09989 1302650012033 agmatinase; Region: agmatinase; TIGR01230 1302650012034 active site 1302650012035 Mn binding site [ion binding]; other site 1302650012036 oligomer interface [polypeptide binding]; other site 1302650012037 S-methylmethionine transporter; Provisional; Region: PRK11387 1302650012038 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1302650012039 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1302650012040 inhibitor-cofactor binding pocket; inhibition site 1302650012041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302650012042 catalytic residue [active] 1302650012043 PAS domain; Region: PAS; smart00091 1302650012044 PAS domain; Region: PAS_9; pfam13426 1302650012045 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1302650012046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302650012047 Walker A motif; other site 1302650012048 ATP binding site [chemical binding]; other site 1302650012049 Walker B motif; other site 1302650012050 arginine finger; other site 1302650012051 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1302650012052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650012053 ATP binding site [chemical binding]; other site 1302650012054 G-X-G motif; other site 1302650012055 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1302650012056 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1302650012057 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1302650012058 protein binding site [polypeptide binding]; other site 1302650012059 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1302650012060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 1302650012061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1302650012062 YycH protein; Region: YycH; pfam07435 1302650012063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1302650012064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302650012065 dimerization interface [polypeptide binding]; other site 1302650012066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302650012067 putative active site [active] 1302650012068 heme pocket [chemical binding]; other site 1302650012069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302650012070 dimer interface [polypeptide binding]; other site 1302650012071 phosphorylation site [posttranslational modification] 1302650012072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302650012073 ATP binding site [chemical binding]; other site 1302650012074 Mg2+ binding site [ion binding]; other site 1302650012075 G-X-G motif; other site 1302650012076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302650012077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302650012078 active site 1302650012079 phosphorylation site [posttranslational modification] 1302650012080 intermolecular recognition site; other site 1302650012081 dimerization interface [polypeptide binding]; other site 1302650012082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302650012083 DNA binding site [nucleotide binding] 1302650012084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1302650012085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1302650012086 GDP-binding site [chemical binding]; other site 1302650012087 ACT binding site; other site 1302650012088 IMP binding site; other site 1302650012089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650012090 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1302650012091 active site 1302650012092 replicative DNA helicase; Provisional; Region: PRK05748 1302650012093 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1302650012094 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1302650012095 Walker A motif; other site 1302650012096 ATP binding site [chemical binding]; other site 1302650012097 Walker B motif; other site 1302650012098 DNA binding loops [nucleotide binding] 1302650012099 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1302650012100 YycC-like protein; Region: YycC; pfam14174 1302650012101 cyanate transporter; Region: CynX; TIGR00896 1302650012102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650012103 putative substrate translocation pore; other site 1302650012104 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1302650012105 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1302650012106 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1302650012107 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1302650012108 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1302650012109 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1302650012110 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1302650012111 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1302650012112 DHH family; Region: DHH; pfam01368 1302650012113 DHHA1 domain; Region: DHHA1; pfam02272 1302650012114 Predicted membrane protein [Function unknown]; Region: COG4241 1302650012115 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1302650012116 Predicted transcriptional regulators [Transcription]; Region: COG1733 1302650012117 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1302650012118 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1302650012119 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1302650012120 DHHA2 domain; Region: DHHA2; pfam02833 1302650012121 ANTAR domain; Region: ANTAR; cl04297 1302650012122 D-galactonate transporter; Region: 2A0114; TIGR00893 1302650012123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650012124 putative substrate translocation pore; other site 1302650012125 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1302650012126 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1302650012127 DNA binding residues [nucleotide binding] 1302650012128 dimer interface [polypeptide binding]; other site 1302650012129 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1302650012130 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1302650012131 SnoaL-like domain; Region: SnoaL_3; pfam13474 1302650012132 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1302650012133 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1302650012134 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1302650012135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650012136 putative substrate translocation pore; other site 1302650012137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302650012138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650012139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650012140 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1302650012141 putative dimerization interface [polypeptide binding]; other site 1302650012142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650012143 Coenzyme A binding pocket [chemical binding]; other site 1302650012144 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302650012145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302650012146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302650012147 dimerization interface [polypeptide binding]; other site 1302650012148 LysE type translocator; Region: LysE; cl00565 1302650012149 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1302650012150 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650012151 active site 1302650012152 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1302650012153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302650012154 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302650012155 MarR family; Region: MarR; pfam01047 1302650012156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650012157 Coenzyme A binding pocket [chemical binding]; other site 1302650012158 Predicted membrane protein [Function unknown]; Region: COG2364 1302650012159 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1302650012160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302650012161 Coenzyme A binding pocket [chemical binding]; other site 1302650012162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1302650012163 RibD C-terminal domain; Region: RibD_C; cl17279 1302650012164 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1302650012165 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1302650012166 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1302650012167 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1302650012168 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1302650012169 active site 1302650012170 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1302650012171 arsenical-resistance protein; Region: acr3; TIGR00832 1302650012172 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1302650012173 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650012174 putative metal binding site [ion binding]; other site 1302650012175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302650012176 dimerization interface [polypeptide binding]; other site 1302650012177 putative DNA binding site [nucleotide binding]; other site 1302650012178 putative Zn2+ binding site [ion binding]; other site 1302650012179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302650012180 salt bridge; other site 1302650012181 non-specific DNA binding site [nucleotide binding]; other site 1302650012182 sequence-specific DNA binding site [nucleotide binding]; other site 1302650012183 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1302650012184 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1302650012185 dimer interface [polypeptide binding]; other site 1302650012186 active site 1302650012187 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1302650012188 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1302650012189 catalytic residues [active] 1302650012190 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1302650012191 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1302650012192 CAAX protease self-immunity; Region: Abi; pfam02517 1302650012193 benzoate transport; Region: 2A0115; TIGR00895 1302650012194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650012195 putative substrate translocation pore; other site 1302650012196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302650012197 maltose O-acetyltransferase; Provisional; Region: PRK10092 1302650012198 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1302650012199 active site 1302650012200 substrate binding site [chemical binding]; other site 1302650012201 trimer interface [polypeptide binding]; other site 1302650012202 CoA binding site [chemical binding]; other site 1302650012203 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302650012204 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1302650012205 putative metal binding site [ion binding]; other site 1302650012206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302650012207 DNA binding site [nucleotide binding] 1302650012208 domain linker motif; other site 1302650012209 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1302650012210 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1302650012211 putative dimerization interface [polypeptide binding]; other site 1302650012212 putative ligand binding site [chemical binding]; other site 1302650012213 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1302650012214 active site 1302650012215 putative catalytic site [active] 1302650012216 DNA binding site [nucleotide binding] 1302650012217 putative phosphate binding site [ion binding]; other site 1302650012218 metal binding site A [ion binding]; metal-binding site 1302650012219 AP binding site [nucleotide binding]; other site 1302650012220 metal binding site B [ion binding]; metal-binding site 1302650012221 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1302650012222 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1302650012223 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1302650012224 dimer interface [polypeptide binding]; other site 1302650012225 ssDNA binding site [nucleotide binding]; other site 1302650012226 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302650012227 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1302650012228 GTP-binding protein YchF; Reviewed; Region: PRK09601 1302650012229 YchF GTPase; Region: YchF; cd01900 1302650012230 G1 box; other site 1302650012231 GTP/Mg2+ binding site [chemical binding]; other site 1302650012232 Switch I region; other site 1302650012233 G2 box; other site 1302650012234 Switch II region; other site 1302650012235 G3 box; other site 1302650012236 G4 box; other site 1302650012237 G5 box; other site 1302650012238 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1302650012239 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1302650012240 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1302650012241 putative [4Fe-4S] binding site [ion binding]; other site 1302650012242 putative molybdopterin cofactor binding site [chemical binding]; other site 1302650012243 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1302650012244 molybdopterin cofactor binding site; other site 1302650012245 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1302650012246 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1302650012247 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1302650012248 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1302650012249 ParB-like nuclease domain; Region: ParB; smart00470 1302650012250 KorB domain; Region: KorB; pfam08535 1302650012251 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1302650012252 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1302650012253 P-loop; other site 1302650012254 Magnesium ion binding site [ion binding]; other site 1302650012255 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1302650012256 Magnesium ion binding site [ion binding]; other site 1302650012257 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1302650012258 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1302650012259 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1302650012260 ParB-like nuclease domain; Region: ParB; smart00470 1302650012261 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1302650012262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302650012263 S-adenosylmethionine binding site [chemical binding]; other site 1302650012264 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1302650012265 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1302650012266 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1302650012267 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1302650012268 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1302650012269 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1302650012270 G1 box; other site 1302650012271 GTP/Mg2+ binding site [chemical binding]; other site 1302650012272 Switch I region; other site 1302650012273 G2 box; other site 1302650012274 Switch II region; other site 1302650012275 G3 box; other site 1302650012276 G4 box; other site 1302650012277 G5 box; other site 1302650012278 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1302650012279 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1302650012280 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1302650012281 G-X-X-G motif; other site 1302650012282 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1302650012283 RxxxH motif; other site 1302650012284 OxaA-like protein precursor; Validated; Region: PRK02944 1302650012285 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1302650012286 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1302650012287 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399