-- dump date 20140618_221217 -- class Genbank::misc_feature -- table misc_feature_note -- id note 361100000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 361100000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 361100000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100000004 Walker A motif; other site 361100000005 ATP binding site [chemical binding]; other site 361100000006 Walker B motif; other site 361100000007 arginine finger; other site 361100000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 361100000009 DnaA box-binding interface [nucleotide binding]; other site 361100000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 361100000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 361100000012 putative DNA binding surface [nucleotide binding]; other site 361100000013 dimer interface [polypeptide binding]; other site 361100000014 beta-clamp/clamp loader binding surface; other site 361100000015 beta-clamp/translesion DNA polymerase binding surface; other site 361100000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 361100000017 recombination protein F; Reviewed; Region: recF; PRK00064 361100000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 361100000019 Walker A/P-loop; other site 361100000020 ATP binding site [chemical binding]; other site 361100000021 Q-loop/lid; other site 361100000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100000023 ABC transporter signature motif; other site 361100000024 Walker B; other site 361100000025 D-loop; other site 361100000026 H-loop/switch region; other site 361100000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 361100000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100000029 Mg2+ binding site [ion binding]; other site 361100000030 G-X-G motif; other site 361100000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 361100000032 anchoring element; other site 361100000033 dimer interface [polypeptide binding]; other site 361100000034 ATP binding site [chemical binding]; other site 361100000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 361100000036 active site 361100000037 putative metal-binding site [ion binding]; other site 361100000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 361100000039 DNA gyrase subunit A; Validated; Region: PRK05560 361100000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 361100000041 CAP-like domain; other site 361100000042 active site 361100000043 primary dimer interface [polypeptide binding]; other site 361100000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100000050 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000051 YaaC-like Protein; Region: YaaC; pfam14175 361100000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 361100000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 361100000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 361100000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 361100000056 active site 361100000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 361100000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 361100000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 361100000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 361100000062 active site 361100000063 multimer interface [polypeptide binding]; other site 361100000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 361100000065 predicted active site [active] 361100000066 catalytic triad [active] 361100000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 361100000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 361100000069 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 361100000070 dimer interface [polypeptide binding]; other site 361100000071 active site 361100000072 motif 1; other site 361100000073 motif 2; other site 361100000074 motif 3; other site 361100000075 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 361100000076 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100000077 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 361100000078 DNA binding residues [nucleotide binding] 361100000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 361100000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 361100000081 Substrate-binding site [chemical binding]; other site 361100000082 Substrate specificity [chemical binding]; other site 361100000083 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 361100000084 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 361100000085 Substrate-binding site [chemical binding]; other site 361100000086 Substrate specificity [chemical binding]; other site 361100000087 Isochorismatase family; Region: Isochorismatase; pfam00857 361100000088 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 361100000089 catalytic triad [active] 361100000090 conserved cis-peptide bond; other site 361100000091 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 361100000092 nucleoside/Zn binding site; other site 361100000093 dimer interface [polypeptide binding]; other site 361100000094 catalytic motif [active] 361100000095 DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812 361100000096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100000097 Walker A motif; other site 361100000098 ATP binding site [chemical binding]; other site 361100000099 Walker B motif; other site 361100000100 arginine finger; other site 361100000101 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 361100000102 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 361100000103 hypothetical protein; Validated; Region: PRK00153 361100000104 recombination protein RecR; Reviewed; Region: recR; PRK00076 361100000105 RecR protein; Region: RecR; pfam02132 361100000106 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 361100000107 putative active site [active] 361100000108 putative metal-binding site [ion binding]; other site 361100000109 tetramer interface [polypeptide binding]; other site 361100000110 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 361100000111 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 361100000112 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000113 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 361100000114 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 361100000115 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 361100000116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100000117 catalytic residue [active] 361100000118 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 361100000119 thymidylate kinase; Validated; Region: tmk; PRK00698 361100000120 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 361100000121 TMP-binding site; other site 361100000122 ATP-binding site [chemical binding]; other site 361100000123 DNA polymerase III subunit delta'; Validated; Region: PRK08058 361100000124 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 361100000125 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 361100000126 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 361100000127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100000128 S-adenosylmethionine binding site [chemical binding]; other site 361100000129 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 361100000130 GIY-YIG motif/motif A; other site 361100000131 putative active site [active] 361100000132 putative metal binding site [ion binding]; other site 361100000133 Predicted methyltransferases [General function prediction only]; Region: COG0313 361100000134 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 361100000135 putative SAM binding site [chemical binding]; other site 361100000136 putative homodimer interface [polypeptide binding]; other site 361100000137 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 361100000138 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 361100000139 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 361100000140 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 361100000141 active site 361100000142 KMSKS motif; other site 361100000143 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 361100000144 tRNA binding surface [nucleotide binding]; other site 361100000145 anticodon binding site; other site 361100000146 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 361100000147 dimer interface [polypeptide binding]; other site 361100000148 putative tRNA-binding site [nucleotide binding]; other site 361100000149 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 361100000150 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 361100000151 active site 361100000152 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 361100000153 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 361100000154 putative active site [active] 361100000155 putative metal binding site [ion binding]; other site 361100000156 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 361100000157 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 361100000158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100000159 S-adenosylmethionine binding site [chemical binding]; other site 361100000160 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 361100000161 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 361100000162 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 361100000163 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 361100000164 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 361100000165 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 361100000166 pur operon repressor; Provisional; Region: PRK09213 361100000167 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 361100000168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100000169 active site 361100000170 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 361100000171 homotrimer interaction site [polypeptide binding]; other site 361100000172 putative active site [active] 361100000173 regulatory protein SpoVG; Reviewed; Region: PRK13259 361100000174 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 361100000175 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 361100000176 Substrate binding site; other site 361100000177 Mg++ binding site; other site 361100000178 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 361100000179 active site 361100000180 substrate binding site [chemical binding]; other site 361100000181 CoA binding site [chemical binding]; other site 361100000182 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 361100000183 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 361100000184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100000185 active site 361100000186 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 361100000187 putative active site [active] 361100000188 catalytic residue [active] 361100000189 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 361100000190 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 361100000191 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 361100000192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100000193 ATP binding site [chemical binding]; other site 361100000194 putative Mg++ binding site [ion binding]; other site 361100000195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100000196 nucleotide binding region [chemical binding]; other site 361100000197 ATP-binding site [chemical binding]; other site 361100000198 TRCF domain; Region: TRCF; pfam03461 361100000199 stage V sporulation protein T; Region: spore_V_T; TIGR02851 361100000200 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 361100000201 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 361100000202 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 361100000203 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 361100000204 putative SAM binding site [chemical binding]; other site 361100000205 putative homodimer interface [polypeptide binding]; other site 361100000206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 361100000207 homodimer interface [polypeptide binding]; other site 361100000208 metal binding site [ion binding]; metal-binding site 361100000209 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 361100000210 homodimer interface [polypeptide binding]; other site 361100000211 active site 361100000212 putative chemical substrate binding site [chemical binding]; other site 361100000213 metal binding site [ion binding]; metal-binding site 361100000214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100000215 RNA binding surface [nucleotide binding]; other site 361100000216 sporulation protein YabP; Region: spore_yabP; TIGR02892 361100000217 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 361100000218 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 361100000219 Septum formation initiator; Region: DivIC; pfam04977 361100000220 hypothetical protein; Provisional; Region: PRK08582 361100000221 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 361100000222 RNA binding site [nucleotide binding]; other site 361100000223 stage II sporulation protein E; Region: spore_II_E; TIGR02865 361100000224 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 361100000225 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 361100000226 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 361100000227 Ligand Binding Site [chemical binding]; other site 361100000228 TilS substrate binding domain; Region: TilS; pfam09179 361100000229 TilS substrate C-terminal domain; Region: TilS_C; smart00977 361100000230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100000231 active site 361100000232 FtsH Extracellular; Region: FtsH_ext; pfam06480 361100000233 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 361100000234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100000235 Walker A motif; other site 361100000236 ATP binding site [chemical binding]; other site 361100000237 Walker B motif; other site 361100000238 arginine finger; other site 361100000239 Peptidase family M41; Region: Peptidase_M41; pfam01434 361100000240 pantothenate kinase; Reviewed; Region: PRK13318 361100000241 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 361100000242 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 361100000243 dimerization interface [polypeptide binding]; other site 361100000244 domain crossover interface; other site 361100000245 redox-dependent activation switch; other site 361100000246 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 361100000247 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 361100000248 dimer interface [polypeptide binding]; other site 361100000249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100000250 catalytic residue [active] 361100000251 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 361100000252 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 361100000253 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 361100000254 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 361100000255 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 361100000256 glutamine binding [chemical binding]; other site 361100000257 catalytic triad [active] 361100000258 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 361100000259 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 361100000260 homodimer interface [polypeptide binding]; other site 361100000261 substrate-cofactor binding pocket; other site 361100000262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100000263 catalytic residue [active] 361100000264 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 361100000265 dihydropteroate synthase; Region: DHPS; TIGR01496 361100000266 substrate binding pocket [chemical binding]; other site 361100000267 dimer interface [polypeptide binding]; other site 361100000268 inhibitor binding site; inhibition site 361100000269 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 361100000270 homooctamer interface [polypeptide binding]; other site 361100000271 active site 361100000272 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 361100000273 catalytic center binding site [active] 361100000274 ATP binding site [chemical binding]; other site 361100000275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100000276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100000277 non-specific DNA binding site [nucleotide binding]; other site 361100000278 salt bridge; other site 361100000279 sequence-specific DNA binding site [nucleotide binding]; other site 361100000280 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 361100000281 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 361100000282 FMN binding site [chemical binding]; other site 361100000283 active site 361100000284 catalytic residues [active] 361100000285 substrate binding site [chemical binding]; other site 361100000286 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 361100000287 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 361100000288 dimer interface [polypeptide binding]; other site 361100000289 putative anticodon binding site; other site 361100000290 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 361100000291 motif 1; other site 361100000292 active site 361100000293 motif 2; other site 361100000294 motif 3; other site 361100000295 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000296 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 361100000297 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 361100000298 UvrB/uvrC motif; Region: UVR; pfam02151 361100000299 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 361100000300 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 361100000301 ADP binding site [chemical binding]; other site 361100000302 phosphagen binding site; other site 361100000303 substrate specificity loop; other site 361100000304 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 361100000305 Clp amino terminal domain; Region: Clp_N; pfam02861 361100000306 Clp amino terminal domain; Region: Clp_N; pfam02861 361100000307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100000308 Walker A motif; other site 361100000309 ATP binding site [chemical binding]; other site 361100000310 Walker B motif; other site 361100000311 arginine finger; other site 361100000312 UvrB/uvrC motif; Region: UVR; pfam02151 361100000313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100000314 Walker A motif; other site 361100000315 ATP binding site [chemical binding]; other site 361100000316 Walker B motif; other site 361100000317 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 361100000318 DNA repair protein RadA; Provisional; Region: PRK11823 361100000319 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 361100000320 Walker A motif/ATP binding site; other site 361100000321 ATP binding site [chemical binding]; other site 361100000322 Walker B motif; other site 361100000323 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 361100000324 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 361100000325 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 361100000326 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 361100000327 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 361100000328 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 361100000329 putative active site [active] 361100000330 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 361100000331 substrate binding site; other site 361100000332 dimer interface; other site 361100000333 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 361100000334 homotrimer interaction site [polypeptide binding]; other site 361100000335 zinc binding site [ion binding]; other site 361100000336 CDP-binding sites; other site 361100000337 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 361100000338 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 361100000339 active site 361100000340 HIGH motif; other site 361100000341 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 361100000342 active site 361100000343 KMSKS motif; other site 361100000344 serine O-acetyltransferase; Region: cysE; TIGR01172 361100000345 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 361100000346 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 361100000347 trimer interface [polypeptide binding]; other site 361100000348 active site 361100000349 substrate binding site [chemical binding]; other site 361100000350 CoA binding site [chemical binding]; other site 361100000351 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 361100000352 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 361100000353 active site 361100000354 HIGH motif; other site 361100000355 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 361100000356 KMSKS motif; other site 361100000357 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 361100000358 tRNA binding surface [nucleotide binding]; other site 361100000359 anticodon binding site; other site 361100000360 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 361100000361 active site 361100000362 metal binding site [ion binding]; metal-binding site 361100000363 dimerization interface [polypeptide binding]; other site 361100000364 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 361100000365 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 361100000366 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 361100000367 YacP-like NYN domain; Region: NYN_YacP; pfam05991 361100000368 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 361100000369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100000370 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 361100000371 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 361100000372 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 361100000373 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 361100000374 putative homodimer interface [polypeptide binding]; other site 361100000375 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 361100000376 heterodimer interface [polypeptide binding]; other site 361100000377 homodimer interface [polypeptide binding]; other site 361100000378 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 361100000379 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 361100000380 23S rRNA interface [nucleotide binding]; other site 361100000381 L7/L12 interface [polypeptide binding]; other site 361100000382 putative thiostrepton binding site; other site 361100000383 L25 interface [polypeptide binding]; other site 361100000384 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 361100000385 mRNA/rRNA interface [nucleotide binding]; other site 361100000386 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 361100000387 23S rRNA interface [nucleotide binding]; other site 361100000388 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 361100000389 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 361100000390 core dimer interface [polypeptide binding]; other site 361100000391 peripheral dimer interface [polypeptide binding]; other site 361100000392 L10 interface [polypeptide binding]; other site 361100000393 L11 interface [polypeptide binding]; other site 361100000394 putative EF-Tu interaction site [polypeptide binding]; other site 361100000395 putative EF-G interaction site [polypeptide binding]; other site 361100000396 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 361100000397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100000398 S-adenosylmethionine binding site [chemical binding]; other site 361100000399 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 361100000400 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 361100000401 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 361100000402 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 361100000403 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 361100000404 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 361100000405 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 361100000406 RPB10 interaction site [polypeptide binding]; other site 361100000407 RPB1 interaction site [polypeptide binding]; other site 361100000408 RPB11 interaction site [polypeptide binding]; other site 361100000409 RPB3 interaction site [polypeptide binding]; other site 361100000410 RPB12 interaction site [polypeptide binding]; other site 361100000411 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 361100000412 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 361100000413 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 361100000414 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 361100000415 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 361100000416 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 361100000417 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 361100000418 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 361100000419 G-loop; other site 361100000420 DNA binding site [nucleotide binding] 361100000421 hypothetical protein; Provisional; Region: PRK06683 361100000422 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 361100000423 S17 interaction site [polypeptide binding]; other site 361100000424 S8 interaction site; other site 361100000425 16S rRNA interaction site [nucleotide binding]; other site 361100000426 streptomycin interaction site [chemical binding]; other site 361100000427 23S rRNA interaction site [nucleotide binding]; other site 361100000428 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 361100000429 30S ribosomal protein S7; Validated; Region: PRK05302 361100000430 elongation factor G; Reviewed; Region: PRK00007 361100000431 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 361100000432 G1 box; other site 361100000433 putative GEF interaction site [polypeptide binding]; other site 361100000434 GTP/Mg2+ binding site [chemical binding]; other site 361100000435 Switch I region; other site 361100000436 G2 box; other site 361100000437 G3 box; other site 361100000438 Switch II region; other site 361100000439 G4 box; other site 361100000440 G5 box; other site 361100000441 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 361100000442 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 361100000443 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 361100000444 elongation factor Tu; Reviewed; Region: PRK00049 361100000445 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 361100000446 G1 box; other site 361100000447 GEF interaction site [polypeptide binding]; other site 361100000448 GTP/Mg2+ binding site [chemical binding]; other site 361100000449 Switch I region; other site 361100000450 G2 box; other site 361100000451 G3 box; other site 361100000452 Switch II region; other site 361100000453 G4 box; other site 361100000454 G5 box; other site 361100000455 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 361100000456 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 361100000457 Antibiotic Binding Site [chemical binding]; other site 361100000458 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 361100000459 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 361100000460 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 361100000461 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 361100000462 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 361100000463 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 361100000464 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 361100000465 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 361100000466 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 361100000467 putative translocon binding site; other site 361100000468 protein-rRNA interface [nucleotide binding]; other site 361100000469 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 361100000470 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 361100000471 G-X-X-G motif; other site 361100000472 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 361100000473 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 361100000474 23S rRNA interface [nucleotide binding]; other site 361100000475 5S rRNA interface [nucleotide binding]; other site 361100000476 putative antibiotic binding site [chemical binding]; other site 361100000477 L25 interface [polypeptide binding]; other site 361100000478 L27 interface [polypeptide binding]; other site 361100000479 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 361100000480 23S rRNA interface [nucleotide binding]; other site 361100000481 putative translocon interaction site; other site 361100000482 signal recognition particle (SRP54) interaction site; other site 361100000483 L23 interface [polypeptide binding]; other site 361100000484 trigger factor interaction site; other site 361100000485 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 361100000486 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 361100000487 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 361100000488 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 361100000489 RNA binding site [nucleotide binding]; other site 361100000490 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 361100000491 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 361100000492 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 361100000493 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 361100000494 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 361100000495 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 361100000496 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 361100000497 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 361100000498 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 361100000499 5S rRNA interface [nucleotide binding]; other site 361100000500 L27 interface [polypeptide binding]; other site 361100000501 23S rRNA interface [nucleotide binding]; other site 361100000502 L5 interface [polypeptide binding]; other site 361100000503 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 361100000504 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 361100000505 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 361100000506 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 361100000507 23S rRNA binding site [nucleotide binding]; other site 361100000508 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 361100000509 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 361100000510 SecY translocase; Region: SecY; pfam00344 361100000511 adenylate kinase; Reviewed; Region: adk; PRK00279 361100000512 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 361100000513 AMP-binding site [chemical binding]; other site 361100000514 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 361100000515 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 361100000516 active site 361100000517 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 361100000518 rRNA binding site [nucleotide binding]; other site 361100000519 predicted 30S ribosome binding site; other site 361100000520 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 361100000521 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 361100000522 30S ribosomal protein S13; Region: bact_S13; TIGR03631 361100000523 30S ribosomal protein S11; Validated; Region: PRK05309 361100000524 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 361100000525 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 361100000526 alphaNTD - beta interaction site [polypeptide binding]; other site 361100000527 alphaNTD homodimer interface [polypeptide binding]; other site 361100000528 alphaNTD - beta' interaction site [polypeptide binding]; other site 361100000529 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 361100000530 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 361100000531 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 361100000532 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 361100000533 Walker A/P-loop; other site 361100000534 ATP binding site [chemical binding]; other site 361100000535 Q-loop/lid; other site 361100000536 ABC transporter signature motif; other site 361100000537 Walker B; other site 361100000538 D-loop; other site 361100000539 H-loop/switch region; other site 361100000540 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 361100000541 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 361100000542 Walker A/P-loop; other site 361100000543 ATP binding site [chemical binding]; other site 361100000544 Q-loop/lid; other site 361100000545 ABC transporter signature motif; other site 361100000546 Walker B; other site 361100000547 D-loop; other site 361100000548 H-loop/switch region; other site 361100000549 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 361100000550 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 361100000551 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 361100000552 dimerization interface 3.5A [polypeptide binding]; other site 361100000553 active site 361100000554 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 361100000555 23S rRNA interface [nucleotide binding]; other site 361100000556 L3 interface [polypeptide binding]; other site 361100000557 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 361100000558 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 361100000559 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 361100000560 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 361100000561 active site 361100000562 metal binding site [ion binding]; metal-binding site 361100000563 Domain of unknown function DUF59; Region: DUF59; pfam01883 361100000564 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 361100000565 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 361100000566 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 361100000567 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 361100000568 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 361100000569 NodB motif; other site 361100000570 putative active site [active] 361100000571 putative catalytic site [active] 361100000572 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000573 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 361100000574 Arginase family; Region: Arginase; cd09989 361100000575 agmatinase; Region: agmatinase; TIGR01230 361100000576 active site 361100000577 Mn binding site [ion binding]; other site 361100000578 oligomer interface [polypeptide binding]; other site 361100000579 Uncharacterized conserved protein [Function unknown]; Region: COG1624 361100000580 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 361100000581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 361100000582 YbbR-like protein; Region: YbbR; pfam07949 361100000583 YbbR-like protein; Region: YbbR; pfam07949 361100000584 YbbR-like protein; Region: YbbR; pfam07949 361100000585 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 361100000586 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 361100000587 active site 361100000588 substrate binding site [chemical binding]; other site 361100000589 metal binding site [ion binding]; metal-binding site 361100000590 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 361100000591 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 361100000592 glutaminase active site [active] 361100000593 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 361100000594 dimer interface [polypeptide binding]; other site 361100000595 active site 361100000596 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 361100000597 dimer interface [polypeptide binding]; other site 361100000598 active site 361100000599 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100000600 Transcriptional regulators [Transcription]; Region: GntR; COG1802 361100000601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100000602 DNA-binding site [nucleotide binding]; DNA binding site 361100000603 FCD domain; Region: FCD; pfam07729 361100000604 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 361100000605 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 361100000606 N- and C-terminal domain interface [polypeptide binding]; other site 361100000607 active site 361100000608 catalytic site [active] 361100000609 metal binding site [ion binding]; metal-binding site 361100000610 carbohydrate binding site [chemical binding]; other site 361100000611 ATP binding site [chemical binding]; other site 361100000612 fructuronate transporter; Provisional; Region: PRK10034; cl15264 361100000613 gluconate transporter; Region: gntP; TIGR00791 361100000614 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 361100000615 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 361100000616 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 361100000617 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 361100000618 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 361100000619 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 361100000620 DoxX; Region: DoxX; cl17842 361100000621 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 361100000622 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 361100000623 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 361100000624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100000625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100000626 DNA binding residues [nucleotide binding] 361100000627 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 361100000628 classical (c) SDRs; Region: SDR_c; cd05233 361100000629 NAD(P) binding site [chemical binding]; other site 361100000630 active site 361100000631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100000632 ABC-ATPase subunit interface; other site 361100000633 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 361100000634 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 361100000635 Walker A/P-loop; other site 361100000636 ATP binding site [chemical binding]; other site 361100000637 Q-loop/lid; other site 361100000638 ABC transporter signature motif; other site 361100000639 Walker B; other site 361100000640 D-loop; other site 361100000641 H-loop/switch region; other site 361100000642 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 361100000643 NIL domain; Region: NIL; pfam09383 361100000644 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 361100000645 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 361100000646 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 361100000647 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 361100000648 putative NAD(P) binding site [chemical binding]; other site 361100000649 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 361100000650 FAD binding domain; Region: FAD_binding_4; pfam01565 361100000651 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 361100000652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100000653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100000654 putative substrate translocation pore; other site 361100000655 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 361100000656 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 361100000657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100000658 putative substrate translocation pore; other site 361100000659 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 361100000660 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 361100000661 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 361100000662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100000663 dimer interface [polypeptide binding]; other site 361100000664 conserved gate region; other site 361100000665 putative PBP binding loops; other site 361100000666 ABC-ATPase subunit interface; other site 361100000667 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 361100000668 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 361100000669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100000670 putative PBP binding loops; other site 361100000671 dimer interface [polypeptide binding]; other site 361100000672 ABC-ATPase subunit interface; other site 361100000673 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 361100000674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100000675 Walker A/P-loop; other site 361100000676 ATP binding site [chemical binding]; other site 361100000677 Q-loop/lid; other site 361100000678 ABC transporter signature motif; other site 361100000679 Walker B; other site 361100000680 D-loop; other site 361100000681 H-loop/switch region; other site 361100000682 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 361100000683 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 361100000684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100000685 Walker A/P-loop; other site 361100000686 ATP binding site [chemical binding]; other site 361100000687 Q-loop/lid; other site 361100000688 ABC transporter signature motif; other site 361100000689 Walker B; other site 361100000690 D-loop; other site 361100000691 H-loop/switch region; other site 361100000692 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 361100000693 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100000694 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100000695 peptide binding site [polypeptide binding]; other site 361100000696 YusW-like protein; Region: YusW; pfam14039 361100000697 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 361100000698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100000699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100000700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100000701 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 361100000702 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 361100000703 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100000704 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100000705 peptide binding site [polypeptide binding]; other site 361100000706 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100000707 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100000708 peptide binding site [polypeptide binding]; other site 361100000709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 361100000710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 361100000711 active site 361100000712 catalytic tetrad [active] 361100000713 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 361100000714 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 361100000715 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 361100000716 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 361100000717 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 361100000718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100000719 putative PBP binding loops; other site 361100000720 dimer interface [polypeptide binding]; other site 361100000721 ABC-ATPase subunit interface; other site 361100000722 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 361100000723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 361100000724 dimerization interface [polypeptide binding]; other site 361100000725 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 361100000726 membrane-bound complex binding site; other site 361100000727 hinge residues; other site 361100000728 PBP superfamily domain; Region: PBP_like; pfam12727 361100000729 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 361100000730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100000731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100000732 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 361100000733 putative dimerization interface [polypeptide binding]; other site 361100000734 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100000735 EamA-like transporter family; Region: EamA; pfam00892 361100000736 YrzO-like protein; Region: YrzO; pfam14142 361100000737 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 361100000738 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 361100000739 putative acyl-acceptor binding pocket; other site 361100000740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 361100000741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 361100000742 DNA binding site [nucleotide binding] 361100000743 domain linker motif; other site 361100000744 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 361100000745 putative ligand binding site [chemical binding]; other site 361100000746 putative dimerization interface [polypeptide binding]; other site 361100000747 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100000748 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100000749 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100000750 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100000751 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 361100000752 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 361100000753 active site 361100000754 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 361100000755 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 361100000756 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 361100000757 lysozyme catalytic site [active] 361100000758 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 361100000759 nucleotide binding site/active site [active] 361100000760 HIT family signature motif; other site 361100000761 catalytic residue [active] 361100000762 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 361100000763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100000764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100000765 ABC transporter; Region: ABC_tran_2; pfam12848 361100000766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100000767 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 361100000768 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 361100000769 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 361100000770 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 361100000771 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 361100000772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100000773 dimer interface [polypeptide binding]; other site 361100000774 conserved gate region; other site 361100000775 putative PBP binding loops; other site 361100000776 ABC-ATPase subunit interface; other site 361100000777 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 361100000778 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 361100000779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100000780 dimer interface [polypeptide binding]; other site 361100000781 conserved gate region; other site 361100000782 putative PBP binding loops; other site 361100000783 ABC-ATPase subunit interface; other site 361100000784 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 361100000785 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100000786 Walker A/P-loop; other site 361100000787 ATP binding site [chemical binding]; other site 361100000788 Q-loop/lid; other site 361100000789 ABC transporter signature motif; other site 361100000790 Walker B; other site 361100000791 D-loop; other site 361100000792 H-loop/switch region; other site 361100000793 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 361100000794 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 361100000795 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100000796 Walker A/P-loop; other site 361100000797 ATP binding site [chemical binding]; other site 361100000798 Q-loop/lid; other site 361100000799 ABC transporter signature motif; other site 361100000800 Walker B; other site 361100000801 D-loop; other site 361100000802 H-loop/switch region; other site 361100000803 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 361100000804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100000805 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 361100000806 active site 361100000807 motif I; other site 361100000808 motif II; other site 361100000809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100000810 motif II; other site 361100000811 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 361100000812 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 361100000813 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 361100000814 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 361100000815 dimer interface [polypeptide binding]; other site 361100000816 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 361100000817 active site 361100000818 Fe binding site [ion binding]; other site 361100000819 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 361100000820 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 361100000821 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 361100000822 amino acid transporter; Region: 2A0306; TIGR00909 361100000823 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 361100000824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100000825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100000826 putative substrate translocation pore; other site 361100000827 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 361100000828 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 361100000829 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 361100000830 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 361100000831 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 361100000832 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 361100000833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 361100000834 helicase 45; Provisional; Region: PTZ00424 361100000835 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 361100000836 ATP binding site [chemical binding]; other site 361100000837 Mg++ binding site [ion binding]; other site 361100000838 motif III; other site 361100000839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100000840 nucleotide binding region [chemical binding]; other site 361100000841 ATP-binding site [chemical binding]; other site 361100000842 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 361100000843 Rhomboid family; Region: Rhomboid; pfam01694 361100000844 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 361100000845 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 361100000846 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 361100000847 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 361100000848 alanine racemase; Reviewed; Region: alr; PRK00053 361100000849 active site 361100000850 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 361100000851 dimer interface [polypeptide binding]; other site 361100000852 substrate binding site [chemical binding]; other site 361100000853 catalytic residues [active] 361100000854 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 361100000855 PemK-like protein; Region: PemK; pfam02452 361100000856 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 361100000857 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 361100000858 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 361100000859 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 361100000860 RNA binding site [nucleotide binding]; other site 361100000861 SprT homologues; Region: SprT; cl01182 361100000862 SprT-like family; Region: SprT-like; pfam10263 361100000863 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000864 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 361100000865 Glycoprotease family; Region: Peptidase_M22; pfam00814 361100000866 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 361100000867 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 361100000868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100000869 Coenzyme A binding pocket [chemical binding]; other site 361100000870 UGMP family protein; Validated; Region: PRK09604 361100000871 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 361100000872 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 361100000873 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 361100000874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100000875 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100000876 ABC transporter; Region: ABC_tran_2; pfam12848 361100000877 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100000878 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 361100000879 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 361100000880 CoA binding domain; Region: CoA_binding; pfam02629 361100000881 CAAX protease self-immunity; Region: Abi; pfam02517 361100000882 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 361100000883 oligomerisation interface [polypeptide binding]; other site 361100000884 mobile loop; other site 361100000885 roof hairpin; other site 361100000886 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 361100000887 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 361100000888 ring oligomerisation interface [polypeptide binding]; other site 361100000889 ATP/Mg binding site [chemical binding]; other site 361100000890 stacking interactions; other site 361100000891 hinge regions; other site 361100000892 GMP synthase; Reviewed; Region: guaA; PRK00074 361100000893 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 361100000894 AMP/PPi binding site [chemical binding]; other site 361100000895 candidate oxyanion hole; other site 361100000896 catalytic triad [active] 361100000897 potential glutamine specificity residues [chemical binding]; other site 361100000898 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 361100000899 ATP Binding subdomain [chemical binding]; other site 361100000900 Ligand Binding sites [chemical binding]; other site 361100000901 Dimerization subdomain; other site 361100000902 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 361100000903 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100000904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100000905 active site 361100000906 phosphorylation site [posttranslational modification] 361100000907 intermolecular recognition site; other site 361100000908 dimerization interface [polypeptide binding]; other site 361100000909 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100000910 DNA binding site [nucleotide binding] 361100000911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100000912 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100000913 dimerization interface [polypeptide binding]; other site 361100000914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100000915 dimer interface [polypeptide binding]; other site 361100000916 phosphorylation site [posttranslational modification] 361100000917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100000918 ATP binding site [chemical binding]; other site 361100000919 Mg2+ binding site [ion binding]; other site 361100000920 G-X-G motif; other site 361100000921 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000922 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 361100000923 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 361100000924 catalytic residues [active] 361100000925 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000926 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 361100000927 putative ligand binding site [chemical binding]; other site 361100000928 putative catalytic site [active] 361100000929 Methyltransferase domain; Region: Methyltransf_31; pfam13847 361100000930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100000931 S-adenosylmethionine binding site [chemical binding]; other site 361100000932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100000933 S-adenosylmethionine binding site [chemical binding]; other site 361100000934 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 361100000935 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 361100000936 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 361100000937 putative NAD(P) binding site [chemical binding]; other site 361100000938 active site 361100000939 putative substrate binding site [chemical binding]; other site 361100000940 Methyltransferase domain; Region: Methyltransf_23; pfam13489 361100000941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100000942 S-adenosylmethionine binding site [chemical binding]; other site 361100000943 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 361100000944 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 361100000945 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 361100000946 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 361100000947 active site 361100000948 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000949 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 361100000950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100000951 DNA-binding site [nucleotide binding]; DNA binding site 361100000952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100000953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100000954 homodimer interface [polypeptide binding]; other site 361100000955 catalytic residue [active] 361100000956 Proline dehydrogenase; Region: Pro_dh; cl03282 361100000957 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000958 Probable transposase; Region: OrfB_IS605; pfam01385 361100000959 EamA-like transporter family; Region: EamA; pfam00892 361100000960 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 361100000961 EamA-like transporter family; Region: EamA; pfam00892 361100000962 Homeodomain-like domain; Region: HTH_23; cl17451 361100000963 putative transposase OrfB; Reviewed; Region: PHA02517 361100000964 HTH-like domain; Region: HTH_21; pfam13276 361100000965 Integrase core domain; Region: rve; pfam00665 361100000966 Integrase core domain; Region: rve_2; pfam13333 361100000967 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 361100000968 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100000969 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 361100000970 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 361100000971 ATP-grasp domain; Region: ATP-grasp; pfam02222 361100000972 adenylosuccinate lyase; Provisional; Region: PRK07492 361100000973 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 361100000974 tetramer interface [polypeptide binding]; other site 361100000975 active site 361100000976 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 361100000977 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 361100000978 ATP binding site [chemical binding]; other site 361100000979 active site 361100000980 substrate binding site [chemical binding]; other site 361100000981 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 361100000982 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 361100000983 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 361100000984 putative active site [active] 361100000985 catalytic triad [active] 361100000986 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 361100000987 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 361100000988 dimerization interface [polypeptide binding]; other site 361100000989 ATP binding site [chemical binding]; other site 361100000990 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 361100000991 dimerization interface [polypeptide binding]; other site 361100000992 ATP binding site [chemical binding]; other site 361100000993 amidophosphoribosyltransferase; Provisional; Region: PRK06781 361100000994 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 361100000995 active site 361100000996 tetramer interface [polypeptide binding]; other site 361100000997 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100000998 active site 361100000999 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 361100001000 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 361100001001 dimerization interface [polypeptide binding]; other site 361100001002 putative ATP binding site [chemical binding]; other site 361100001003 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 361100001004 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 361100001005 active site 361100001006 substrate binding site [chemical binding]; other site 361100001007 cosubstrate binding site; other site 361100001008 catalytic site [active] 361100001009 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 361100001010 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 361100001011 purine monophosphate binding site [chemical binding]; other site 361100001012 dimer interface [polypeptide binding]; other site 361100001013 putative catalytic residues [active] 361100001014 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 361100001015 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 361100001016 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 361100001017 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 361100001018 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 361100001019 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 361100001020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 361100001021 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 361100001022 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 361100001023 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 361100001024 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 361100001025 putative active site [active] 361100001026 dimer interface [polypeptide binding]; other site 361100001027 substrate binding site [chemical binding]; other site 361100001028 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 361100001029 Part of AAA domain; Region: AAA_19; pfam13245 361100001030 Family description; Region: UvrD_C_2; pfam13538 361100001031 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 361100001032 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 361100001033 nucleotide binding pocket [chemical binding]; other site 361100001034 K-X-D-G motif; other site 361100001035 catalytic site [active] 361100001036 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 361100001037 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 361100001038 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 361100001039 Dimer interface [polypeptide binding]; other site 361100001040 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 361100001041 putative dimer interface [polypeptide binding]; other site 361100001042 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 361100001043 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 361100001044 putative dimer interface [polypeptide binding]; other site 361100001045 hypothetical protein; Provisional; Region: PRK10621 361100001046 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 361100001047 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 361100001048 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 361100001049 Glutamate binding site [chemical binding]; other site 361100001050 homodimer interface [polypeptide binding]; other site 361100001051 NAD binding site [chemical binding]; other site 361100001052 catalytic residues [active] 361100001053 Isochorismatase family; Region: Isochorismatase; pfam00857 361100001054 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 361100001055 catalytic triad [active] 361100001056 conserved cis-peptide bond; other site 361100001057 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 361100001058 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 361100001059 Walker A/P-loop; other site 361100001060 ATP binding site [chemical binding]; other site 361100001061 Q-loop/lid; other site 361100001062 ABC transporter signature motif; other site 361100001063 Walker B; other site 361100001064 D-loop; other site 361100001065 H-loop/switch region; other site 361100001066 NIL domain; Region: NIL; pfam09383 361100001067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100001068 dimer interface [polypeptide binding]; other site 361100001069 conserved gate region; other site 361100001070 ABC-ATPase subunit interface; other site 361100001071 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 361100001072 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 361100001073 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 361100001074 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 361100001075 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 361100001076 P loop; other site 361100001077 Nucleotide binding site [chemical binding]; other site 361100001078 DTAP/Switch II; other site 361100001079 Switch I; other site 361100001080 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 361100001081 putative dimer interface [polypeptide binding]; other site 361100001082 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100001083 MarR family; Region: MarR; pfam01047 361100001084 MarR family; Region: MarR_2; cl17246 361100001085 yiaA/B two helix domain; Region: YiaAB; pfam05360 361100001086 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 361100001087 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 361100001088 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 361100001089 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 361100001090 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 361100001091 GatB domain; Region: GatB_Yqey; pfam02637 361100001092 putative lipid kinase; Reviewed; Region: PRK13337 361100001093 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 361100001094 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 361100001095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 361100001096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100001097 S-adenosylmethionine binding site [chemical binding]; other site 361100001098 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 361100001099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100001100 motif II; other site 361100001101 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 361100001102 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 361100001103 inhibitor-cofactor binding pocket; inhibition site 361100001104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100001105 catalytic residue [active] 361100001106 PAS domain; Region: PAS_9; pfam13426 361100001107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100001108 putative active site [active] 361100001109 heme pocket [chemical binding]; other site 361100001110 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 361100001111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100001112 Walker A motif; other site 361100001113 ATP binding site [chemical binding]; other site 361100001114 Walker B motif; other site 361100001115 arginine finger; other site 361100001116 succinic semialdehyde dehydrogenase; Region: PLN02278 361100001117 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 361100001118 tetramerization interface [polypeptide binding]; other site 361100001119 NAD(P) binding site [chemical binding]; other site 361100001120 catalytic residues [active] 361100001121 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 361100001122 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 361100001123 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 361100001124 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 361100001125 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 361100001126 putative active site [active] 361100001127 putative metal binding site [ion binding]; other site 361100001128 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 361100001129 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 361100001130 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 361100001131 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 361100001132 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 361100001133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100001134 S-adenosylmethionine binding site [chemical binding]; other site 361100001135 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 361100001136 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 361100001137 FMN binding site [chemical binding]; other site 361100001138 active site 361100001139 catalytic residues [active] 361100001140 substrate binding site [chemical binding]; other site 361100001141 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 361100001142 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 361100001143 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 361100001144 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 361100001145 PAS domain S-box; Region: sensory_box; TIGR00229 361100001146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100001147 putative active site [active] 361100001148 heme pocket [chemical binding]; other site 361100001149 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 361100001150 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 361100001151 metal binding site [ion binding]; metal-binding site 361100001152 active site 361100001153 I-site; other site 361100001154 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 361100001155 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 361100001156 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 361100001157 TPP binding site [chemical binding]; other site 361100001158 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 361100001159 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 361100001160 TPP-binding site [chemical binding]; other site 361100001161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 361100001162 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 361100001163 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 361100001164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100001165 FeS/SAM binding site; other site 361100001166 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 361100001167 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 361100001168 FAD binding domain; Region: FAD_binding_4; pfam01565 361100001169 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 361100001170 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 361100001171 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 361100001172 metal binding site [ion binding]; metal-binding site 361100001173 dimer interface [polypeptide binding]; other site 361100001174 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 361100001175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 361100001176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 361100001177 Integrase core domain; Region: rve; pfam00665 361100001178 transposase/IS protein; Provisional; Region: PRK09183 361100001179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100001180 Walker A motif; other site 361100001181 ATP binding site [chemical binding]; other site 361100001182 Walker B motif; other site 361100001183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100001184 non-specific DNA binding site [nucleotide binding]; other site 361100001185 salt bridge; other site 361100001186 sequence-specific DNA binding site [nucleotide binding]; other site 361100001187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 361100001188 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100001189 TPR motif; other site 361100001190 binding surface 361100001191 TPR repeat; Region: TPR_11; pfam13414 361100001192 seryl-tRNA synthetase; Provisional; Region: PRK05431 361100001193 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 361100001194 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 361100001195 dimer interface [polypeptide binding]; other site 361100001196 active site 361100001197 motif 1; other site 361100001198 motif 2; other site 361100001199 motif 3; other site 361100001200 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 361100001201 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 361100001202 catalytic triad [active] 361100001203 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 361100001204 AMP-binding enzyme; Region: AMP-binding; pfam00501 361100001205 acyl-activating enzyme (AAE) consensus motif; other site 361100001206 AMP binding site [chemical binding]; other site 361100001207 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 361100001208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100001209 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100001210 putative substrate translocation pore; other site 361100001211 putative transposase OrfB; Reviewed; Region: PHA02517 361100001212 HTH-like domain; Region: HTH_21; pfam13276 361100001213 Integrase core domain; Region: rve; pfam00665 361100001214 Integrase core domain; Region: rve_2; pfam13333 361100001215 Transposase; Region: HTH_Tnp_1; pfam01527 361100001216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 361100001217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 361100001218 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 361100001219 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 361100001220 Protein of unknown function DUF45; Region: DUF45; pfam01863 361100001221 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 361100001222 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 361100001223 active site 361100001224 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 361100001225 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 361100001226 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 361100001227 metal binding site [ion binding]; metal-binding site 361100001228 putative dimer interface [polypeptide binding]; other site 361100001229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100001230 S-adenosylmethionine binding site [chemical binding]; other site 361100001231 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 361100001232 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 361100001233 catalytic residue [active] 361100001234 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 361100001235 catalytic residues [active] 361100001236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 361100001237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100001238 peroxiredoxin; Region: AhpC; TIGR03137 361100001239 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 361100001240 dimer interface [polypeptide binding]; other site 361100001241 decamer (pentamer of dimers) interface [polypeptide binding]; other site 361100001242 catalytic triad [active] 361100001243 peroxidatic and resolving cysteines [active] 361100001244 5-methylribose kinase; Reviewed; Region: PRK12396 361100001245 Phosphotransferase enzyme family; Region: APH; pfam01636 361100001246 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 361100001247 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 361100001248 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 361100001249 intersubunit interface [polypeptide binding]; other site 361100001250 active site 361100001251 Zn2+ binding site [ion binding]; other site 361100001252 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 361100001253 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100001254 ABC-ATPase subunit interface; other site 361100001255 dimer interface [polypeptide binding]; other site 361100001256 putative PBP binding regions; other site 361100001257 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 361100001258 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100001259 ABC-ATPase subunit interface; other site 361100001260 dimer interface [polypeptide binding]; other site 361100001261 putative PBP binding regions; other site 361100001262 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 361100001263 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 361100001264 putative ligand binding residues [chemical binding]; other site 361100001265 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 361100001266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 361100001267 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 361100001268 DNA binding domain, excisionase family; Region: excise; TIGR01764 361100001269 Sm and related proteins; Region: Sm_like; cl00259 361100001270 Sm1 motif; other site 361100001271 RNA binding site [nucleotide binding]; other site 361100001272 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 361100001273 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 361100001274 hypothetical protein; Provisional; Region: PRK06851 361100001275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100001276 Walker A motif; other site 361100001277 ATP binding site [chemical binding]; other site 361100001278 NTPase; Region: NTPase_1; cl17478 361100001279 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 361100001280 benzoate transport; Region: 2A0115; TIGR00895 361100001281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100001282 putative substrate translocation pore; other site 361100001283 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 361100001284 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 361100001285 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 361100001286 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 361100001287 [2Fe-2S] cluster binding site [ion binding]; other site 361100001288 Fatty acid desaturase; Region: FA_desaturase; pfam00487 361100001289 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 361100001290 putative di-iron ligands [ion binding]; other site 361100001291 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 361100001292 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 361100001293 DXD motif; other site 361100001294 HEAT repeats; Region: HEAT_2; pfam13646 361100001295 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100001296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100001297 active site 361100001298 phosphorylation site [posttranslational modification] 361100001299 intermolecular recognition site; other site 361100001300 dimerization interface [polypeptide binding]; other site 361100001301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100001302 dimer interface [polypeptide binding]; other site 361100001303 conserved gate region; other site 361100001304 putative PBP binding loops; other site 361100001305 ABC-ATPase subunit interface; other site 361100001306 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 361100001307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 361100001308 substrate binding pocket [chemical binding]; other site 361100001309 membrane-bound complex binding site; other site 361100001310 hinge residues; other site 361100001311 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 361100001312 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 361100001313 Walker A/P-loop; other site 361100001314 ATP binding site [chemical binding]; other site 361100001315 Q-loop/lid; other site 361100001316 ABC transporter signature motif; other site 361100001317 Walker B; other site 361100001318 D-loop; other site 361100001319 H-loop/switch region; other site 361100001320 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 361100001321 HAMP domain; Region: HAMP; pfam00672 361100001322 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100001323 dimer interface [polypeptide binding]; other site 361100001324 putative CheW interface [polypeptide binding]; other site 361100001325 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 361100001326 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 361100001327 Ca binding site [ion binding]; other site 361100001328 active site 361100001329 catalytic site [active] 361100001330 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 361100001331 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 361100001332 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 361100001333 active site turn [active] 361100001334 phosphorylation site [posttranslational modification] 361100001335 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 361100001336 putative catalytic site [active] 361100001337 putative metal binding site [ion binding]; other site 361100001338 putative phosphate binding site [ion binding]; other site 361100001339 Predicted membrane protein [Function unknown]; Region: COG1511 361100001340 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 361100001341 Predicted membrane protein [Function unknown]; Region: COG1511 361100001342 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 361100001343 dinuclear metal binding motif [ion binding]; other site 361100001344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100001345 DNA topoisomerase III; Provisional; Region: PRK07726 361100001346 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 361100001347 active site 361100001348 putative interdomain interaction site [polypeptide binding]; other site 361100001349 putative metal-binding site [ion binding]; other site 361100001350 putative nucleotide binding site [chemical binding]; other site 361100001351 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 361100001352 domain I; other site 361100001353 DNA binding groove [nucleotide binding] 361100001354 phosphate binding site [ion binding]; other site 361100001355 domain II; other site 361100001356 domain III; other site 361100001357 nucleotide binding site [chemical binding]; other site 361100001358 catalytic site [active] 361100001359 domain IV; other site 361100001360 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100001361 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 361100001362 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 361100001363 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100001364 FtsX-like permease family; Region: FtsX; pfam02687 361100001365 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100001366 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100001367 Walker A/P-loop; other site 361100001368 ATP binding site [chemical binding]; other site 361100001369 Q-loop/lid; other site 361100001370 ABC transporter signature motif; other site 361100001371 Walker B; other site 361100001372 D-loop; other site 361100001373 H-loop/switch region; other site 361100001374 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 361100001375 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 361100001376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100001377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100001378 Walker A/P-loop; other site 361100001379 ATP binding site [chemical binding]; other site 361100001380 Q-loop/lid; other site 361100001381 ABC transporter signature motif; other site 361100001382 Walker B; other site 361100001383 D-loop; other site 361100001384 H-loop/switch region; other site 361100001385 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 361100001386 active site 361100001387 putative metal-binding site [ion binding]; other site 361100001388 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 361100001389 substrate binding site [chemical binding]; other site 361100001390 multimerization interface [polypeptide binding]; other site 361100001391 ATP binding site [chemical binding]; other site 361100001392 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 361100001393 thiamine phosphate binding site [chemical binding]; other site 361100001394 active site 361100001395 pyrophosphate binding site [ion binding]; other site 361100001396 Predicted esterase [General function prediction only]; Region: COG0400 361100001397 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 361100001398 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 361100001399 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 361100001400 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 361100001401 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100001402 dimerization interface [polypeptide binding]; other site 361100001403 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100001404 dimer interface [polypeptide binding]; other site 361100001405 putative CheW interface [polypeptide binding]; other site 361100001406 Domain of unknown function DUF77; Region: DUF77; pfam01910 361100001407 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 361100001408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100001409 dimer interface [polypeptide binding]; other site 361100001410 conserved gate region; other site 361100001411 putative PBP binding loops; other site 361100001412 ABC-ATPase subunit interface; other site 361100001413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 361100001414 NMT1/THI5 like; Region: NMT1; pfam09084 361100001415 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 361100001416 ABC transporter; Region: ABC_tran; pfam00005 361100001417 Q-loop/lid; other site 361100001418 ABC transporter signature motif; other site 361100001419 Walker B; other site 361100001420 D-loop; other site 361100001421 H-loop/switch region; other site 361100001422 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 361100001423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100001424 Walker A/P-loop; other site 361100001425 ATP binding site [chemical binding]; other site 361100001426 Q-loop/lid; other site 361100001427 ABC transporter signature motif; other site 361100001428 Walker B; other site 361100001429 D-loop; other site 361100001430 H-loop/switch region; other site 361100001431 ABC transporter; Region: ABC_tran_2; pfam12848 361100001432 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100001433 Glyco_18 domain; Region: Glyco_18; smart00636 361100001434 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 361100001435 active site 361100001436 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 361100001437 Interdomain contacts; other site 361100001438 Cytokine receptor motif; other site 361100001439 CBD_II domain; Region: CBD_II; smart00637 361100001440 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 361100001441 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 361100001442 catalytic residues [active] 361100001443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100001444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100001445 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 361100001446 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100001447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100001448 putative substrate translocation pore; other site 361100001449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100001450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100001451 non-specific DNA binding site [nucleotide binding]; other site 361100001452 salt bridge; other site 361100001453 sequence-specific DNA binding site [nucleotide binding]; other site 361100001454 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 361100001455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100001456 putative substrate translocation pore; other site 361100001457 Uncharacterized conserved protein [Function unknown]; Region: COG3379 361100001458 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 361100001459 YesK-like protein; Region: YesK; pfam14150 361100001460 prolyl-tRNA synthetase; Provisional; Region: PRK08661 361100001461 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 361100001462 dimer interface [polypeptide binding]; other site 361100001463 motif 1; other site 361100001464 active site 361100001465 motif 2; other site 361100001466 motif 3; other site 361100001467 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 361100001468 anticodon binding site; other site 361100001469 zinc-binding site [ion binding]; other site 361100001470 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 361100001471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 361100001472 nucleotide binding site [chemical binding]; other site 361100001473 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 361100001474 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 361100001475 putative metal binding site [ion binding]; other site 361100001476 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 361100001477 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 361100001478 putative metal binding site [ion binding]; other site 361100001479 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 361100001480 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 361100001481 putative metal binding site [ion binding]; other site 361100001482 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 361100001483 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 361100001484 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 361100001485 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 361100001486 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 361100001487 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 361100001488 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 361100001489 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 361100001490 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 361100001491 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 361100001492 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 361100001493 Low molecular weight phosphatase family; Region: LMWPc; cd00115 361100001494 active site 361100001495 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 361100001496 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 361100001497 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 361100001498 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 361100001499 Soluble P-type ATPase [General function prediction only]; Region: COG4087 361100001500 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100001501 EamA-like transporter family; Region: EamA; pfam00892 361100001502 EamA-like transporter family; Region: EamA; pfam00892 361100001503 YhhN-like protein; Region: YhhN; pfam07947 361100001504 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 361100001505 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 361100001506 Catalytic site [active] 361100001507 Tetratricopeptide repeat; Region: TPR_16; pfam13432 361100001508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100001509 binding surface 361100001510 TPR motif; other site 361100001511 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 361100001512 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 361100001513 Predicted membrane protein [Function unknown]; Region: COG2510 361100001514 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 361100001515 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 361100001516 calcium/proton exchanger (cax); Region: cax; TIGR00378 361100001517 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 361100001518 YfkD-like protein; Region: YfkD; pfam14167 361100001519 Radical SAM superfamily; Region: Radical_SAM; pfam04055 361100001520 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100001521 FeS/SAM binding site; other site 361100001522 YfkB-like domain; Region: YfkB; pfam08756 361100001523 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 361100001524 Fumarase C-terminus; Region: Fumerase_C; pfam05683 361100001525 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 361100001526 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 361100001527 NodB motif; other site 361100001528 active site 361100001529 catalytic site [active] 361100001530 Cd binding site [ion binding]; other site 361100001531 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 361100001532 endonuclease III; Region: ENDO3c; smart00478 361100001533 minor groove reading motif; other site 361100001534 helix-hairpin-helix signature motif; other site 361100001535 substrate binding pocket [chemical binding]; other site 361100001536 active site 361100001537 TRAM domain; Region: TRAM; pfam01938 361100001538 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 361100001539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100001540 S-adenosylmethionine binding site [chemical binding]; other site 361100001541 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 361100001542 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 361100001543 dimerization interface 3.5A [polypeptide binding]; other site 361100001544 active site 361100001545 HipA-like C-terminal domain; Region: HipA_C; pfam07804 361100001546 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 361100001547 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 361100001548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100001549 Walker A motif; other site 361100001550 ATP binding site [chemical binding]; other site 361100001551 Walker B motif; other site 361100001552 arginine finger; other site 361100001553 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 361100001554 hypothetical protein; Validated; Region: PRK06748 361100001555 S-methylmethionine transporter; Provisional; Region: PRK11387 361100001556 acetylornithine deacetylase; Validated; Region: PRK08596 361100001557 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 361100001558 metal binding site [ion binding]; metal-binding site 361100001559 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100001560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100001561 non-specific DNA binding site [nucleotide binding]; other site 361100001562 salt bridge; other site 361100001563 sequence-specific DNA binding site [nucleotide binding]; other site 361100001564 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 361100001565 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 361100001566 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 361100001567 glutaminase A; Region: Gln_ase; TIGR03814 361100001568 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 361100001569 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 361100001570 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 361100001571 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 361100001572 active site turn [active] 361100001573 phosphorylation site [posttranslational modification] 361100001574 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100001575 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100001576 Sm and related proteins; Region: Sm_like; cl00259 361100001577 heptamer interface [polypeptide binding]; other site 361100001578 Sm1 motif; other site 361100001579 hexamer interface [polypeptide binding]; other site 361100001580 RNA binding site [nucleotide binding]; other site 361100001581 Sm2 motif; other site 361100001582 Sm and related proteins; Region: Sm_like; cl00259 361100001583 heptamer interface [polypeptide binding]; other site 361100001584 Sm1 motif; other site 361100001585 hexamer interface [polypeptide binding]; other site 361100001586 RNA binding site [nucleotide binding]; other site 361100001587 Sm2 motif; other site 361100001588 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 361100001589 active site 361100001590 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 361100001591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 361100001592 active site 361100001593 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 361100001594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100001595 NAD(P) binding site [chemical binding]; other site 361100001596 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 361100001597 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 361100001598 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 361100001599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100001600 NAD(P) binding site [chemical binding]; other site 361100001601 active site 361100001602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 361100001603 active site 361100001604 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 361100001605 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 361100001606 active site 361100001607 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 361100001608 Pyruvate formate lyase 1; Region: PFL1; cd01678 361100001609 coenzyme A binding site [chemical binding]; other site 361100001610 active site 361100001611 catalytic residues [active] 361100001612 glycine loop; other site 361100001613 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 361100001614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100001615 FeS/SAM binding site; other site 361100001616 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 361100001617 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 361100001618 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 361100001619 YfhE-like protein; Region: YfhE; pfam14152 361100001620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100001621 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 361100001622 Amidohydrolase; Region: Amidohydro_4; pfam13147 361100001623 active site 361100001624 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 361100001625 TIGR01777 family protein; Region: yfcH 361100001626 putative NAD(P) binding site [chemical binding]; other site 361100001627 putative active site [active] 361100001628 recombination regulator RecX; Provisional; Region: recX; PRK14135 361100001629 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 361100001630 YpzG-like protein; Region: YpzG; pfam14139 361100001631 Small acid-soluble spore protein K family; Region: SspK; pfam08176 361100001632 WVELL protein; Region: WVELL; pfam14043 361100001633 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 361100001634 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 361100001635 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 361100001636 minor groove reading motif; other site 361100001637 helix-hairpin-helix signature motif; other site 361100001638 substrate binding pocket [chemical binding]; other site 361100001639 active site 361100001640 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 361100001641 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 361100001642 DNA binding and oxoG recognition site [nucleotide binding] 361100001643 YgaB-like protein; Region: YgaB; pfam14182 361100001644 hypothetical protein; Provisional; Region: PRK13662 361100001645 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 361100001646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100001647 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 361100001648 Walker A/P-loop; other site 361100001649 ATP binding site [chemical binding]; other site 361100001650 Q-loop/lid; other site 361100001651 ABC transporter signature motif; other site 361100001652 Walker B; other site 361100001653 D-loop; other site 361100001654 H-loop/switch region; other site 361100001655 Predicted membrane protein [Function unknown]; Region: COG4129 361100001656 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 361100001657 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 361100001658 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 361100001659 active site 361100001660 dimer interface [polypeptide binding]; other site 361100001661 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 361100001662 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 361100001663 active site 361100001664 FMN binding site [chemical binding]; other site 361100001665 substrate binding site [chemical binding]; other site 361100001666 3Fe-4S cluster binding site [ion binding]; other site 361100001667 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 361100001668 domain_subunit interface; other site 361100001669 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 361100001670 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 361100001671 inhibitor-cofactor binding pocket; inhibition site 361100001672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100001673 catalytic residue [active] 361100001674 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 361100001675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100001676 Walker A/P-loop; other site 361100001677 ATP binding site [chemical binding]; other site 361100001678 Q-loop/lid; other site 361100001679 ABC transporter signature motif; other site 361100001680 Walker B; other site 361100001681 D-loop; other site 361100001682 H-loop/switch region; other site 361100001683 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 361100001684 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 361100001685 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 361100001686 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 361100001687 Ion channel; Region: Ion_trans_2; pfam07885 361100001688 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 361100001689 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 361100001690 catalytic triad [active] 361100001691 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 361100001692 metal binding site 2 [ion binding]; metal-binding site 361100001693 putative DNA binding helix; other site 361100001694 metal binding site 1 [ion binding]; metal-binding site 361100001695 dimer interface [polypeptide binding]; other site 361100001696 structural Zn2+ binding site [ion binding]; other site 361100001697 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 361100001698 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100001699 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (5S ribosomal RNA) 361100001700 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 361100001701 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 361100001702 active site 361100001703 Int/Topo IB signature motif; other site 361100001704 DNA binding site [nucleotide binding] 361100001705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100001706 non-specific DNA binding site [nucleotide binding]; other site 361100001707 salt bridge; other site 361100001708 sequence-specific DNA binding site [nucleotide binding]; other site 361100001709 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100001710 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 361100001711 catalytic residues [active] 361100001712 catalytic nucleophile [active] 361100001713 Presynaptic Site I dimer interface [polypeptide binding]; other site 361100001714 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 361100001715 Synaptic Flat tetramer interface [polypeptide binding]; other site 361100001716 Synaptic Site I dimer interface [polypeptide binding]; other site 361100001717 DNA binding site [nucleotide binding] 361100001718 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 361100001719 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100001720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100001721 TPR motif; other site 361100001722 binding surface 361100001723 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 361100001724 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 361100001725 hypothetical protein; Provisional; Region: PRK12378 361100001726 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 361100001727 nudix motif; other site 361100001728 Transglycosylase; Region: Transgly; pfam00912 361100001729 Thioredoxin; Region: Thioredoxin_4; pfam13462 361100001730 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 361100001731 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 361100001732 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 361100001733 epoxyqueuosine reductase; Region: TIGR00276 361100001734 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 361100001735 Putative amidase domain; Region: Amidase_6; pfam12671 361100001736 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 361100001737 PAS fold; Region: PAS_4; pfam08448 361100001738 PAS domain S-box; Region: sensory_box; TIGR00229 361100001739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100001740 putative active site [active] 361100001741 heme pocket [chemical binding]; other site 361100001742 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 361100001743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 361100001744 metal binding site [ion binding]; metal-binding site 361100001745 active site 361100001746 I-site; other site 361100001747 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 361100001748 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 361100001749 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 361100001750 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 361100001751 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 361100001752 heme-binding site [chemical binding]; other site 361100001753 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 361100001754 Leucine-rich repeats; other site 361100001755 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100001756 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100001757 Substrate binding site [chemical binding]; other site 361100001758 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100001759 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100001760 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100001761 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100001762 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100001763 BCCT family transporter; Region: BCCT; pfam02028 361100001764 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 361100001765 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 361100001766 FOG: PKD repeat [General function prediction only]; Region: COG3291 361100001767 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 361100001768 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 361100001769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 361100001770 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 361100001771 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 361100001772 Cache domain; Region: Cache_1; pfam02743 361100001773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100001774 dimerization interface [polypeptide binding]; other site 361100001775 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 361100001776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100001777 dimer interface [polypeptide binding]; other site 361100001778 putative CheW interface [polypeptide binding]; other site 361100001779 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 361100001780 PAS domain; Region: PAS; smart00091 361100001781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100001782 ATP binding site [chemical binding]; other site 361100001783 Mg2+ binding site [ion binding]; other site 361100001784 G-X-G motif; other site 361100001785 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 361100001786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100001787 active site 361100001788 phosphorylation site [posttranslational modification] 361100001789 intermolecular recognition site; other site 361100001790 dimerization interface [polypeptide binding]; other site 361100001791 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 361100001792 Citrate transporter; Region: CitMHS; pfam03600 361100001793 hypothetical protein; Provisional; Region: PRK12784 361100001794 NosL; Region: NosL; cl01769 361100001795 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 361100001796 Ankyrin repeat; Region: Ank; pfam00023 361100001797 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 361100001798 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 361100001799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100001800 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 361100001801 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 361100001802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100001803 Walker A/P-loop; other site 361100001804 ATP binding site [chemical binding]; other site 361100001805 Q-loop/lid; other site 361100001806 ABC transporter signature motif; other site 361100001807 Walker B; other site 361100001808 D-loop; other site 361100001809 H-loop/switch region; other site 361100001810 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 361100001811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100001812 dimer interface [polypeptide binding]; other site 361100001813 putative PBP binding loops; other site 361100001814 ABC-ATPase subunit interface; other site 361100001815 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 361100001816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 361100001817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100001818 dimer interface [polypeptide binding]; other site 361100001819 conserved gate region; other site 361100001820 putative PBP binding loops; other site 361100001821 ABC-ATPase subunit interface; other site 361100001822 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 361100001823 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 361100001824 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100001825 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 361100001826 active site 361100001827 metal binding site [ion binding]; metal-binding site 361100001828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100001829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100001830 active site 361100001831 phosphorylation site [posttranslational modification] 361100001832 intermolecular recognition site; other site 361100001833 dimerization interface [polypeptide binding]; other site 361100001834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100001835 DNA binding site [nucleotide binding] 361100001836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100001837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100001838 dimer interface [polypeptide binding]; other site 361100001839 phosphorylation site [posttranslational modification] 361100001840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100001841 ATP binding site [chemical binding]; other site 361100001842 Mg2+ binding site [ion binding]; other site 361100001843 G-X-G motif; other site 361100001844 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 361100001845 putative active site [active] 361100001846 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 361100001847 Cache domain; Region: Cache_1; pfam02743 361100001848 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100001849 dimerization interface [polypeptide binding]; other site 361100001850 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 361100001851 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100001852 dimer interface [polypeptide binding]; other site 361100001853 putative CheW interface [polypeptide binding]; other site 361100001854 sensory histidine kinase DcuS; Provisional; Region: PRK11086 361100001855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100001856 ATP binding site [chemical binding]; other site 361100001857 Mg2+ binding site [ion binding]; other site 361100001858 G-X-G motif; other site 361100001859 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 361100001860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100001861 active site 361100001862 phosphorylation site [posttranslational modification] 361100001863 intermolecular recognition site; other site 361100001864 dimerization interface [polypeptide binding]; other site 361100001865 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 361100001866 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 361100001867 Malic enzyme, N-terminal domain; Region: malic; pfam00390 361100001868 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 361100001869 putative NAD(P) binding site [chemical binding]; other site 361100001870 EamA-like transporter family; Region: EamA; pfam00892 361100001871 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 361100001872 EamA-like transporter family; Region: EamA; pfam00892 361100001873 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 361100001874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100001875 DNA-binding site [nucleotide binding]; DNA binding site 361100001876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100001877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100001878 homodimer interface [polypeptide binding]; other site 361100001879 catalytic residue [active] 361100001880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 361100001881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100001882 Coenzyme A binding pocket [chemical binding]; other site 361100001883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100001884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100001885 dimerization interface [polypeptide binding]; other site 361100001886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100001887 dimer interface [polypeptide binding]; other site 361100001888 phosphorylation site [posttranslational modification] 361100001889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100001890 ATP binding site [chemical binding]; other site 361100001891 Mg2+ binding site [ion binding]; other site 361100001892 G-X-G motif; other site 361100001893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100001894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100001895 active site 361100001896 phosphorylation site [posttranslational modification] 361100001897 intermolecular recognition site; other site 361100001898 dimerization interface [polypeptide binding]; other site 361100001899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100001900 DNA binding site [nucleotide binding] 361100001901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 361100001902 Arrestin_N terminal like; Region: LDB19; pfam13002 361100001903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100001904 Coenzyme A binding pocket [chemical binding]; other site 361100001905 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 361100001906 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 361100001907 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 361100001908 catalytic loop [active] 361100001909 iron binding site [ion binding]; other site 361100001910 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 361100001911 4Fe-4S binding domain; Region: Fer4; pfam00037 361100001912 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 361100001913 [4Fe-4S] binding site [ion binding]; other site 361100001914 molybdopterin cofactor binding site; other site 361100001915 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 361100001916 molybdopterin cofactor binding site; other site 361100001917 Uncharacterized conserved protein [Function unknown]; Region: COG2427 361100001918 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 361100001919 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 361100001920 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 361100001921 putative active site [active] 361100001922 catalytic site [active] 361100001923 putative metal binding site [ion binding]; other site 361100001924 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 361100001925 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 361100001926 hexamer interface [polypeptide binding]; other site 361100001927 ligand binding site [chemical binding]; other site 361100001928 putative active site [active] 361100001929 NAD(P) binding site [chemical binding]; other site 361100001930 amino acid transporter; Region: 2A0306; TIGR00909 361100001931 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 361100001932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100001933 dimerization interface [polypeptide binding]; other site 361100001934 putative DNA binding site [nucleotide binding]; other site 361100001935 putative Zn2+ binding site [ion binding]; other site 361100001936 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 361100001937 metal-binding site [ion binding] 361100001938 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 361100001939 Heavy-metal-associated domain; Region: HMA; pfam00403 361100001940 metal-binding site [ion binding] 361100001941 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 361100001942 Soluble P-type ATPase [General function prediction only]; Region: COG4087 361100001943 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 361100001944 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 361100001945 active site 361100001946 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100001947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100001948 non-specific DNA binding site [nucleotide binding]; other site 361100001949 salt bridge; other site 361100001950 sequence-specific DNA binding site [nucleotide binding]; other site 361100001951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100001952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100001953 binding surface 361100001954 TPR motif; other site 361100001955 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 361100001956 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 361100001957 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 361100001958 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 361100001959 active site 361100001960 Zn binding site [ion binding]; other site 361100001961 Uncharacterized conserved protein [Function unknown]; Region: COG0398 361100001962 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 361100001963 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 361100001964 VanW like protein; Region: VanW; pfam04294 361100001965 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 361100001966 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 361100001967 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 361100001968 Nucleoside recognition; Region: Gate; pfam07670 361100001969 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 361100001970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100001971 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 361100001972 putative metal binding site [ion binding]; other site 361100001973 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 361100001974 Domain of unknown function DUF21; Region: DUF21; pfam01595 361100001975 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 361100001976 Transporter associated domain; Region: CorC_HlyC; smart01091 361100001977 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 361100001978 Aspartase; Region: Aspartase; cd01357 361100001979 active sites [active] 361100001980 tetramer interface [polypeptide binding]; other site 361100001981 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 361100001982 L-lactate permease; Region: Lactate_perm; cl00701 361100001983 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 361100001984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100001985 dimerization interface [polypeptide binding]; other site 361100001986 putative Zn2+ binding site [ion binding]; other site 361100001987 putative DNA binding site [nucleotide binding]; other site 361100001988 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 361100001989 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 361100001990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100001991 putative substrate translocation pore; other site 361100001992 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 361100001993 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 361100001994 siderophore binding site; other site 361100001995 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 361100001996 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100001997 ABC-ATPase subunit interface; other site 361100001998 dimer interface [polypeptide binding]; other site 361100001999 putative PBP binding regions; other site 361100002000 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 361100002001 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100002002 ABC-ATPase subunit interface; other site 361100002003 dimer interface [polypeptide binding]; other site 361100002004 putative PBP binding regions; other site 361100002005 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 361100002006 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 361100002007 Walker A/P-loop; other site 361100002008 ATP binding site [chemical binding]; other site 361100002009 Q-loop/lid; other site 361100002010 ABC transporter signature motif; other site 361100002011 Walker B; other site 361100002012 D-loop; other site 361100002013 H-loop/switch region; other site 361100002014 Methyltransferase domain; Region: Methyltransf_31; pfam13847 361100002015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100002016 S-adenosylmethionine binding site [chemical binding]; other site 361100002017 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 361100002018 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 361100002019 substrate-cofactor binding pocket; other site 361100002020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100002021 catalytic residue [active] 361100002022 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 361100002023 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 361100002024 NAD binding site [chemical binding]; other site 361100002025 homodimer interface [polypeptide binding]; other site 361100002026 active site 361100002027 putative substrate binding site [chemical binding]; other site 361100002028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100002029 active site 361100002030 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 361100002031 nudix motif; other site 361100002032 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 361100002033 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 361100002034 metal ion-dependent adhesion site (MIDAS); other site 361100002035 MoxR-like ATPases [General function prediction only]; Region: COG0714 361100002036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100002037 Walker A motif; other site 361100002038 ATP binding site [chemical binding]; other site 361100002039 Walker B motif; other site 361100002040 arginine finger; other site 361100002041 cardiolipin synthetase; Reviewed; Region: PRK12452 361100002042 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 361100002043 putative active site [active] 361100002044 catalytic site [active] 361100002045 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 361100002046 putative active site [active] 361100002047 catalytic site [active] 361100002048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100002049 PAS domain; Region: PAS_9; pfam13426 361100002050 putative active site [active] 361100002051 heme pocket [chemical binding]; other site 361100002052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 361100002053 metal binding site [ion binding]; metal-binding site 361100002054 active site 361100002055 I-site; other site 361100002056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 361100002057 Amino acid permease; Region: AA_permease_2; pfam13520 361100002058 Spore germination protein; Region: Spore_permease; cl17796 361100002059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100002060 DNA-binding site [nucleotide binding]; DNA binding site 361100002061 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 361100002062 UTRA domain; Region: UTRA; pfam07702 361100002063 potential frameshift: common BLAST hit: gi|218234137|ref|YP_002365427.1| PTS system, trehalose-specific IIBC component 361100002064 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 361100002065 active site turn [active] 361100002066 phosphorylation site [posttranslational modification] 361100002067 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 361100002068 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 361100002069 potential frameshift: common BLAST hit: gi|218234137|ref|YP_002365427.1| PTS system, trehalose-specific IIBC component 361100002070 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 361100002071 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 361100002072 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 361100002073 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 361100002074 Ca binding site [ion binding]; other site 361100002075 active site 361100002076 catalytic site [active] 361100002077 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100002078 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100002079 Spore germination protein; Region: Spore_permease; cl17796 361100002080 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100002081 CAAX protease self-immunity; Region: Abi; pfam02517 361100002082 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 361100002083 active site 361100002084 ATP binding site [chemical binding]; other site 361100002085 substrate binding site [chemical binding]; other site 361100002086 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 361100002087 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 361100002088 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 361100002089 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 361100002090 Walker A/P-loop; other site 361100002091 ATP binding site [chemical binding]; other site 361100002092 Q-loop/lid; other site 361100002093 ABC transporter signature motif; other site 361100002094 Walker B; other site 361100002095 D-loop; other site 361100002096 H-loop/switch region; other site 361100002097 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 361100002098 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 361100002099 substrate binding pocket [chemical binding]; other site 361100002100 membrane-bound complex binding site; other site 361100002101 hinge residues; other site 361100002102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002103 dimer interface [polypeptide binding]; other site 361100002104 conserved gate region; other site 361100002105 putative PBP binding loops; other site 361100002106 ABC-ATPase subunit interface; other site 361100002107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002108 dimer interface [polypeptide binding]; other site 361100002109 conserved gate region; other site 361100002110 putative PBP binding loops; other site 361100002111 ABC-ATPase subunit interface; other site 361100002112 S-methylmethionine transporter; Provisional; Region: PRK11387 361100002113 OsmC-like protein; Region: OsmC; pfam02566 361100002114 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 361100002115 nucleotide binding site/active site [active] 361100002116 HIT family signature motif; other site 361100002117 catalytic residue [active] 361100002118 RNA polymerase sigma factor; Provisional; Region: PRK12542 361100002119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100002120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100002121 DNA binding residues [nucleotide binding] 361100002122 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 361100002123 Predicted transcriptional regulator [Transcription]; Region: COG2378 361100002124 HTH domain; Region: HTH_11; pfam08279 361100002125 WYL domain; Region: WYL; pfam13280 361100002126 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 361100002127 RibD C-terminal domain; Region: RibD_C; cl17279 361100002128 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 361100002129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100002130 dimerization interface [polypeptide binding]; other site 361100002131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100002132 dimer interface [polypeptide binding]; other site 361100002133 phosphorylation site [posttranslational modification] 361100002134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100002135 ATP binding site [chemical binding]; other site 361100002136 Mg2+ binding site [ion binding]; other site 361100002137 G-X-G motif; other site 361100002138 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100002139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100002140 active site 361100002141 phosphorylation site [posttranslational modification] 361100002142 intermolecular recognition site; other site 361100002143 dimerization interface [polypeptide binding]; other site 361100002144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100002145 DNA binding site [nucleotide binding] 361100002146 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 361100002147 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 361100002148 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 361100002149 Sulfate transporter family; Region: Sulfate_transp; pfam00916 361100002150 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 361100002151 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 361100002152 Ligand Binding Site [chemical binding]; other site 361100002153 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 361100002154 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 361100002155 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 361100002156 peptide binding site [polypeptide binding]; other site 361100002157 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 361100002158 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 361100002159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002160 dimer interface [polypeptide binding]; other site 361100002161 conserved gate region; other site 361100002162 putative PBP binding loops; other site 361100002163 ABC-ATPase subunit interface; other site 361100002164 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 361100002165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002166 dimer interface [polypeptide binding]; other site 361100002167 conserved gate region; other site 361100002168 putative PBP binding loops; other site 361100002169 ABC-ATPase subunit interface; other site 361100002170 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 361100002171 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100002172 Walker A/P-loop; other site 361100002173 ATP binding site [chemical binding]; other site 361100002174 Q-loop/lid; other site 361100002175 ABC transporter signature motif; other site 361100002176 Walker B; other site 361100002177 D-loop; other site 361100002178 H-loop/switch region; other site 361100002179 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 361100002180 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 361100002181 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100002182 Walker A/P-loop; other site 361100002183 ATP binding site [chemical binding]; other site 361100002184 Q-loop/lid; other site 361100002185 ABC transporter signature motif; other site 361100002186 Walker B; other site 361100002187 D-loop; other site 361100002188 H-loop/switch region; other site 361100002189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 361100002190 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 361100002191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002192 putative substrate translocation pore; other site 361100002193 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100002194 MarR family; Region: MarR; pfam01047 361100002195 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 361100002196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002197 putative substrate translocation pore; other site 361100002198 Transcriptional regulators [Transcription]; Region: PurR; COG1609 361100002199 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 361100002200 DNA binding site [nucleotide binding] 361100002201 domain linker motif; other site 361100002202 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 361100002203 dimerization interface [polypeptide binding]; other site 361100002204 ligand binding site [chemical binding]; other site 361100002205 sodium binding site [ion binding]; other site 361100002206 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 361100002207 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 361100002208 substrate binding site [chemical binding]; other site 361100002209 dimer interface [polypeptide binding]; other site 361100002210 ATP binding site [chemical binding]; other site 361100002211 D-ribose pyranase; Provisional; Region: PRK11797 361100002212 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 361100002213 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 361100002214 Walker A/P-loop; other site 361100002215 ATP binding site [chemical binding]; other site 361100002216 Q-loop/lid; other site 361100002217 ABC transporter signature motif; other site 361100002218 Walker B; other site 361100002219 D-loop; other site 361100002220 H-loop/switch region; other site 361100002221 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 361100002222 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 361100002223 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 361100002224 TM-ABC transporter signature motif; other site 361100002225 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 361100002226 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 361100002227 ligand binding site [chemical binding]; other site 361100002228 dimerization interface [polypeptide binding]; other site 361100002229 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 361100002230 active site 361100002231 intersubunit interactions; other site 361100002232 catalytic residue [active] 361100002233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 361100002234 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 361100002235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100002237 putative substrate translocation pore; other site 361100002238 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 361100002239 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 361100002240 putative NAD(P) binding site [chemical binding]; other site 361100002241 catalytic Zn binding site [ion binding]; other site 361100002242 Ion channel; Region: Ion_trans_2; pfam07885 361100002243 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 361100002244 Zn binding site [ion binding]; other site 361100002245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 361100002246 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 361100002247 Probable transposase; Region: OrfB_IS605; pfam01385 361100002248 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 361100002249 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 361100002250 putative catalytic site [active] 361100002251 metal binding site A [ion binding]; metal-binding site 361100002252 phosphate binding site [ion binding]; other site 361100002253 metal binding site C [ion binding]; metal-binding site 361100002254 metal binding site B [ion binding]; metal-binding site 361100002255 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 361100002256 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 361100002257 dimer interface [polypeptide binding]; other site 361100002258 active site 361100002259 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 361100002260 substrate binding site [chemical binding]; other site 361100002261 catalytic residue [active] 361100002262 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 361100002263 FAD binding domain; Region: FAD_binding_4; pfam01565 361100002264 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 361100002265 VanZ like family; Region: VanZ; pfam04892 361100002266 RDD family; Region: RDD; pfam06271 361100002267 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 361100002268 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 361100002269 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100002270 dimer interface [polypeptide binding]; other site 361100002271 putative CheW interface [polypeptide binding]; other site 361100002272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 361100002273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 361100002274 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100002275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100002276 non-specific DNA binding site [nucleotide binding]; other site 361100002277 salt bridge; other site 361100002278 sequence-specific DNA binding site [nucleotide binding]; other site 361100002279 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 361100002280 active site 361100002281 catalytic site [active] 361100002282 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 361100002283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002284 putative substrate translocation pore; other site 361100002285 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 361100002286 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 361100002287 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 361100002288 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 361100002289 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 361100002290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100002291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100002292 non-specific DNA binding site [nucleotide binding]; other site 361100002293 salt bridge; other site 361100002294 sequence-specific DNA binding site [nucleotide binding]; other site 361100002295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100002296 Coenzyme A binding pocket [chemical binding]; other site 361100002297 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 361100002298 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 361100002299 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 361100002300 TrkA-N domain; Region: TrkA_N; pfam02254 361100002301 TrkA-C domain; Region: TrkA_C; pfam02080 361100002302 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 361100002303 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 361100002304 Subunit I/III interface [polypeptide binding]; other site 361100002305 Subunit III/IV interface [polypeptide binding]; other site 361100002306 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 361100002307 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 361100002308 D-pathway; other site 361100002309 Putative ubiquinol binding site [chemical binding]; other site 361100002310 Low-spin heme (heme b) binding site [chemical binding]; other site 361100002311 Putative water exit pathway; other site 361100002312 Binuclear center (heme o3/CuB) [ion binding]; other site 361100002313 K-pathway; other site 361100002314 Putative proton exit pathway; other site 361100002315 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 361100002316 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 361100002317 S-methylmethionine transporter; Provisional; Region: PRK11387 361100002318 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 361100002319 putative active site [active] 361100002320 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 361100002321 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 361100002322 metal binding site [ion binding]; metal-binding site 361100002323 dimer interface [polypeptide binding]; other site 361100002324 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 361100002325 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 361100002326 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 361100002327 Na binding site [ion binding]; other site 361100002328 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100002329 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 361100002330 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100002331 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100002332 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 361100002333 Nucleoside recognition; Region: Gate; pfam07670 361100002334 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 361100002335 Nucleoside recognition; Region: Gate; pfam07670 361100002336 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 361100002337 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 361100002338 G1 box; other site 361100002339 GTP/Mg2+ binding site [chemical binding]; other site 361100002340 Switch I region; other site 361100002341 G2 box; other site 361100002342 G3 box; other site 361100002343 Switch II region; other site 361100002344 G4 box; other site 361100002345 G5 box; other site 361100002346 FeoA domain; Region: FeoA; pfam04023 361100002347 phosphate binding protein; Region: ptsS_2; TIGR02136 361100002348 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 361100002349 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 361100002350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002351 dimer interface [polypeptide binding]; other site 361100002352 conserved gate region; other site 361100002353 putative PBP binding loops; other site 361100002354 ABC-ATPase subunit interface; other site 361100002355 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 361100002356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002357 dimer interface [polypeptide binding]; other site 361100002358 conserved gate region; other site 361100002359 putative PBP binding loops; other site 361100002360 ABC-ATPase subunit interface; other site 361100002361 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 361100002362 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100002363 FOG: CBS domain [General function prediction only]; Region: COG0517 361100002364 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 361100002365 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 361100002366 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 361100002367 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100002368 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100002369 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100002370 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 361100002371 Peptidase family M23; Region: Peptidase_M23; pfam01551 361100002372 Putative transcription activator [Transcription]; Region: TenA; COG0819 361100002373 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 361100002374 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 361100002375 Walker A/P-loop; other site 361100002376 ATP binding site [chemical binding]; other site 361100002377 Q-loop/lid; other site 361100002378 ABC transporter signature motif; other site 361100002379 Walker B; other site 361100002380 D-loop; other site 361100002381 H-loop/switch region; other site 361100002382 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 361100002383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002384 dimer interface [polypeptide binding]; other site 361100002385 conserved gate region; other site 361100002386 putative PBP binding loops; other site 361100002387 ABC-ATPase subunit interface; other site 361100002388 NMT1/THI5 like; Region: NMT1; pfam09084 361100002389 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 361100002390 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 361100002391 thiamine phosphate binding site [chemical binding]; other site 361100002392 active site 361100002393 pyrophosphate binding site [ion binding]; other site 361100002394 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 361100002395 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 361100002396 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 361100002397 thiS-thiF/thiG interaction site; other site 361100002398 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 361100002399 ThiS interaction site; other site 361100002400 putative active site [active] 361100002401 tetramer interface [polypeptide binding]; other site 361100002402 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 361100002403 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 361100002404 ATP binding site [chemical binding]; other site 361100002405 substrate interface [chemical binding]; other site 361100002406 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 361100002407 dimer interface [polypeptide binding]; other site 361100002408 substrate binding site [chemical binding]; other site 361100002409 ATP binding site [chemical binding]; other site 361100002410 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 361100002411 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 361100002412 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 361100002413 Soluble P-type ATPase [General function prediction only]; Region: COG4087 361100002414 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 361100002415 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 361100002416 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 361100002417 Ligand Binding Site [chemical binding]; other site 361100002418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100002420 putative substrate translocation pore; other site 361100002421 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100002422 MarR family; Region: MarR; pfam01047 361100002423 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 361100002424 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 361100002425 active site 361100002426 nucleophile elbow; other site 361100002427 FtsX-like permease family; Region: FtsX; pfam02687 361100002428 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 361100002429 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100002430 FtsX-like permease family; Region: FtsX; pfam02687 361100002431 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100002432 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100002433 Walker A/P-loop; other site 361100002434 ATP binding site [chemical binding]; other site 361100002435 Q-loop/lid; other site 361100002436 ABC transporter signature motif; other site 361100002437 Walker B; other site 361100002438 D-loop; other site 361100002439 H-loop/switch region; other site 361100002440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 361100002441 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 361100002442 TM-ABC transporter signature motif; other site 361100002443 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 361100002444 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 361100002445 Walker A/P-loop; other site 361100002446 ATP binding site [chemical binding]; other site 361100002447 Q-loop/lid; other site 361100002448 ABC transporter signature motif; other site 361100002449 Walker B; other site 361100002450 D-loop; other site 361100002451 H-loop/switch region; other site 361100002452 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 361100002453 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 361100002454 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 361100002455 putative ligand binding site [chemical binding]; other site 361100002456 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 361100002457 short chain dehydrogenase; Provisional; Region: PRK06701 361100002458 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 361100002459 NAD binding site [chemical binding]; other site 361100002460 metal binding site [ion binding]; metal-binding site 361100002461 active site 361100002462 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 361100002463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 361100002464 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 361100002465 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 361100002466 catalytic residues [active] 361100002467 putative disulfide oxidoreductase; Provisional; Region: PRK03113 361100002468 YhdB-like protein; Region: YhdB; pfam14148 361100002469 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 361100002470 Spore germination protein; Region: Spore_permease; cl17796 361100002471 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100002472 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100002473 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100002474 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 361100002475 putative FMN binding site [chemical binding]; other site 361100002476 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 361100002477 SpoVR like protein; Region: SpoVR; pfam04293 361100002478 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 361100002479 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 361100002480 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 361100002481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100002482 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 361100002483 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 361100002484 active site residue [active] 361100002485 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 361100002486 putative homodimer interface [polypeptide binding]; other site 361100002487 putative homotetramer interface [polypeptide binding]; other site 361100002488 putative metal binding site [ion binding]; other site 361100002489 putative homodimer-homodimer interface [polypeptide binding]; other site 361100002490 putative allosteric switch controlling residues; other site 361100002491 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 361100002492 CPxP motif; other site 361100002493 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 361100002494 active site residue [active] 361100002495 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 361100002496 active site residue [active] 361100002497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100002498 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 361100002499 CPxP motif; other site 361100002500 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 361100002501 CPxP motif; other site 361100002502 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 361100002503 active site residue [active] 361100002504 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 361100002505 active site residue [active] 361100002506 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 361100002507 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 361100002508 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 361100002509 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 361100002510 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 361100002511 NADP binding site [chemical binding]; other site 361100002512 dimer interface [polypeptide binding]; other site 361100002513 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 361100002514 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 361100002515 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 361100002516 PhoU domain; Region: PhoU; pfam01895 361100002517 PhoU domain; Region: PhoU; pfam01895 361100002518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100002520 putative substrate translocation pore; other site 361100002521 Uncharacterized conserved protein [Function unknown]; Region: COG3589 361100002522 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 361100002523 HTH domain; Region: HTH_11; pfam08279 361100002524 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 361100002525 Mga helix-turn-helix domain; Region: Mga; pfam05043 361100002526 PRD domain; Region: PRD; pfam00874 361100002527 PRD domain; Region: PRD; pfam00874 361100002528 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 361100002529 active site 361100002530 P-loop; other site 361100002531 phosphorylation site [posttranslational modification] 361100002532 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 361100002533 active site 361100002534 phosphorylation site [posttranslational modification] 361100002535 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 361100002536 active site 361100002537 methionine cluster; other site 361100002538 phosphorylation site [posttranslational modification] 361100002539 metal binding site [ion binding]; metal-binding site 361100002540 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 361100002541 active site 361100002542 P-loop; other site 361100002543 phosphorylation site [posttranslational modification] 361100002544 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 361100002545 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 361100002546 Uncharacterized conserved protein [Function unknown]; Region: COG3589 361100002547 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 361100002548 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100002549 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100002550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 361100002551 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 361100002552 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100002553 FtsX-like permease family; Region: FtsX; pfam02687 361100002554 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100002555 Walker A/P-loop; other site 361100002556 ATP binding site [chemical binding]; other site 361100002557 ABC transporter; Region: ABC_tran; pfam00005 361100002558 Q-loop/lid; other site 361100002559 ABC transporter signature motif; other site 361100002560 Walker B; other site 361100002561 D-loop; other site 361100002562 H-loop/switch region; other site 361100002563 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 361100002564 HlyD family secretion protein; Region: HlyD_3; pfam13437 361100002565 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 361100002566 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 361100002567 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 361100002568 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 361100002569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002570 dimer interface [polypeptide binding]; other site 361100002571 conserved gate region; other site 361100002572 ABC-ATPase subunit interface; other site 361100002573 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 361100002574 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 361100002575 dimanganese center [ion binding]; other site 361100002576 CotJB protein; Region: CotJB; pfam12652 361100002577 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 361100002578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100002579 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 361100002580 active site 361100002581 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 361100002582 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 361100002583 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 361100002584 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 361100002585 putative DNA binding site [nucleotide binding]; other site 361100002586 putative homodimer interface [polypeptide binding]; other site 361100002587 Uncharacterized conserved protein [Function unknown]; Region: COG3339 361100002588 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 361100002589 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 361100002590 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 361100002591 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 361100002592 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100002593 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 361100002594 active site 361100002595 metal binding site [ion binding]; metal-binding site 361100002596 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 361100002597 Interdomain contacts; other site 361100002598 Cytokine receptor motif; other site 361100002599 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 361100002600 amino acid transporter; Region: 2A0306; TIGR00909 361100002601 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 361100002602 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 361100002603 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 361100002604 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 361100002605 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 361100002606 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 361100002607 putative active site [active] 361100002608 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 361100002609 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 361100002610 putative active site [active] 361100002611 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 361100002612 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 361100002613 active site turn [active] 361100002614 phosphorylation site [posttranslational modification] 361100002615 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 361100002616 Uncharacterized conserved protein [Function unknown]; Region: COG3589 361100002617 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 361100002618 DoxX; Region: DoxX; pfam07681 361100002619 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 361100002620 hypothetical protein; Provisional; Region: PRK06770 361100002621 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100002622 EamA-like transporter family; Region: EamA; pfam00892 361100002623 EamA-like transporter family; Region: EamA; pfam00892 361100002624 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 361100002625 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 361100002626 AsnC family; Region: AsnC_trans_reg; pfam01037 361100002627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100002628 Coenzyme A binding pocket [chemical binding]; other site 361100002629 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 361100002630 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 361100002631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100002632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100002633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100002635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002636 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100002637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100002638 dimerization interface [polypeptide binding]; other site 361100002639 putative Zn2+ binding site [ion binding]; other site 361100002640 putative DNA binding site [nucleotide binding]; other site 361100002641 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 361100002642 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 361100002643 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 361100002644 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 361100002645 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 361100002646 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 361100002647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100002648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002649 putative substrate translocation pore; other site 361100002650 intracellular protease, PfpI family; Region: PfpI; TIGR01382 361100002651 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 361100002652 proposed catalytic triad [active] 361100002653 conserved cys residue [active] 361100002654 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 361100002655 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 361100002656 tetramer interface [polypeptide binding]; other site 361100002657 heme binding pocket [chemical binding]; other site 361100002658 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 361100002659 domain interactions; other site 361100002660 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 361100002661 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 361100002662 Spore germination protein; Region: Spore_permease; cl17796 361100002663 glutamate racemase; Provisional; Region: PRK00865 361100002664 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 361100002665 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 361100002666 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 361100002667 tetrameric interface [polypeptide binding]; other site 361100002668 activator binding site; other site 361100002669 NADP binding site [chemical binding]; other site 361100002670 substrate binding site [chemical binding]; other site 361100002671 catalytic residues [active] 361100002672 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100002673 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 361100002674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100002675 Walker A/P-loop; other site 361100002676 ATP binding site [chemical binding]; other site 361100002677 Q-loop/lid; other site 361100002678 ABC transporter signature motif; other site 361100002679 Walker B; other site 361100002680 D-loop; other site 361100002681 H-loop/switch region; other site 361100002682 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100002683 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 361100002684 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 361100002685 Walker A/P-loop; other site 361100002686 ATP binding site [chemical binding]; other site 361100002687 Q-loop/lid; other site 361100002688 ABC transporter signature motif; other site 361100002689 Walker B; other site 361100002690 D-loop; other site 361100002691 H-loop/switch region; other site 361100002692 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 361100002693 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 361100002694 substrate binding pocket [chemical binding]; other site 361100002695 membrane-bound complex binding site; other site 361100002696 hinge residues; other site 361100002697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002698 dimer interface [polypeptide binding]; other site 361100002699 conserved gate region; other site 361100002700 putative PBP binding loops; other site 361100002701 ABC-ATPase subunit interface; other site 361100002702 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 361100002703 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 361100002704 Walker A/P-loop; other site 361100002705 ATP binding site [chemical binding]; other site 361100002706 Q-loop/lid; other site 361100002707 ABC transporter signature motif; other site 361100002708 Walker B; other site 361100002709 D-loop; other site 361100002710 H-loop/switch region; other site 361100002711 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 361100002712 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 361100002713 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 361100002714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 361100002715 hypothetical protein; Provisional; Region: PRK13676 361100002716 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 361100002717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 361100002718 Histidine kinase; Region: HisKA_3; pfam07730 361100002719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100002720 ATP binding site [chemical binding]; other site 361100002721 Mg2+ binding site [ion binding]; other site 361100002722 G-X-G motif; other site 361100002723 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100002724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100002725 active site 361100002726 phosphorylation site [posttranslational modification] 361100002727 intermolecular recognition site; other site 361100002728 dimerization interface [polypeptide binding]; other site 361100002729 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100002730 dimerization interface [polypeptide binding]; other site 361100002731 DNA binding residues [nucleotide binding] 361100002732 WxL domain surface cell wall-binding; Region: WxL; pfam13731 361100002733 WxL domain surface cell wall-binding; Region: WxL; pfam13731 361100002734 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 361100002735 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 361100002736 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 361100002737 acetolactate synthase; Reviewed; Region: PRK08617 361100002738 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 361100002739 PYR/PP interface [polypeptide binding]; other site 361100002740 dimer interface [polypeptide binding]; other site 361100002741 TPP binding site [chemical binding]; other site 361100002742 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 361100002743 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 361100002744 TPP-binding site [chemical binding]; other site 361100002745 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 361100002746 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 361100002747 active site 361100002748 DNA binding site [nucleotide binding] 361100002749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 361100002750 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 361100002751 active site 361100002752 motif I; other site 361100002753 motif II; other site 361100002754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100002755 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 361100002756 amidase catalytic site [active] 361100002757 Zn binding residues [ion binding]; other site 361100002758 substrate binding site [chemical binding]; other site 361100002759 S-layer homology domain; Region: SLH; pfam00395 361100002760 S-layer homology domain; Region: SLH; pfam00395 361100002761 S-layer homology domain; Region: SLH; pfam00395 361100002762 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 361100002763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100002764 FeS/SAM binding site; other site 361100002765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 361100002766 Transposase; Region: HTH_Tnp_1; cl17663 361100002767 Helix-turn-helix domain; Region: HTH_28; pfam13518 361100002768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 361100002769 HTH-like domain; Region: HTH_21; pfam13276 361100002770 Integrase core domain; Region: rve; pfam00665 361100002771 Integrase core domain; Region: rve_2; pfam13333 361100002772 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 361100002773 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 361100002774 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 361100002775 acyl-activating enzyme (AAE) consensus motif; other site 361100002776 acyl-activating enzyme (AAE) consensus motif; other site 361100002777 putative AMP binding site [chemical binding]; other site 361100002778 putative active site [active] 361100002779 putative CoA binding site [chemical binding]; other site 361100002780 high affinity sulphate transporter 1; Region: sulP; TIGR00815 361100002781 Sulfate transporter family; Region: Sulfate_transp; pfam00916 361100002782 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 361100002783 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 361100002784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 361100002785 ATP binding site [chemical binding]; other site 361100002786 putative Mg++ binding site [ion binding]; other site 361100002787 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 361100002788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100002789 nucleotide binding region [chemical binding]; other site 361100002790 ATP-binding site [chemical binding]; other site 361100002791 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 361100002792 stage V sporulation protein B; Region: spore_V_B; TIGR02900 361100002793 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 361100002794 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 361100002795 S-layer homology domain; Region: SLH; pfam00395 361100002796 S-layer homology domain; Region: SLH; pfam00395 361100002797 S-layer homology domain; Region: SLH; pfam00395 361100002798 S-layer homology domain; Region: SLH; pfam00395 361100002799 S-layer homology domain; Region: SLH; pfam00395 361100002800 S-layer homology domain; Region: SLH; pfam00395 361100002801 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 361100002802 DHHW protein; Region: DHHW; pfam14286 361100002803 DHHW protein; Region: DHHW; pfam14286 361100002804 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 361100002805 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 361100002806 enoyl-CoA hydratase; Provisional; Region: PRK07659 361100002807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 361100002808 substrate binding site [chemical binding]; other site 361100002809 oxyanion hole (OAH) forming residues; other site 361100002810 trimer interface [polypeptide binding]; other site 361100002811 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 361100002812 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 361100002813 putative oligomer interface [polypeptide binding]; other site 361100002814 putative active site [active] 361100002815 metal binding site [ion binding]; metal-binding site 361100002816 S-layer homology domain; Region: SLH; pfam00395 361100002817 S-layer homology domain; Region: SLH; pfam00395 361100002818 S-layer homology domain; Region: SLH; pfam00395 361100002819 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 361100002820 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 361100002821 active site 361100002822 metal binding site [ion binding]; metal-binding site 361100002823 TIGR01177 family protein; Region: TIGR01177 361100002824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100002825 S-adenosylmethionine binding site [chemical binding]; other site 361100002826 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 361100002827 proline racemase; Provisional; Region: PRK13969 361100002828 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 361100002829 ornithine cyclodeaminase; Validated; Region: PRK08618 361100002830 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 361100002831 NAD(P) binding site [chemical binding]; other site 361100002832 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 361100002833 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 361100002834 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 361100002835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002836 dimer interface [polypeptide binding]; other site 361100002837 conserved gate region; other site 361100002838 putative PBP binding loops; other site 361100002839 ABC-ATPase subunit interface; other site 361100002840 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 361100002841 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 361100002842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100002843 dimer interface [polypeptide binding]; other site 361100002844 conserved gate region; other site 361100002845 putative PBP binding loops; other site 361100002846 ABC-ATPase subunit interface; other site 361100002847 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 361100002848 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100002849 Q-loop/lid; other site 361100002850 ABC transporter signature motif; other site 361100002851 Walker B; other site 361100002852 D-loop; other site 361100002853 H-loop/switch region; other site 361100002854 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 361100002855 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 361100002856 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100002857 Walker A/P-loop; other site 361100002858 ATP binding site [chemical binding]; other site 361100002859 Q-loop/lid; other site 361100002860 ABC transporter signature motif; other site 361100002861 Walker B; other site 361100002862 D-loop; other site 361100002863 H-loop/switch region; other site 361100002864 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 361100002865 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 361100002866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100002867 putative substrate translocation pore; other site 361100002868 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 361100002869 PAS domain; Region: PAS; smart00091 361100002870 putative active site [active] 361100002871 heme pocket [chemical binding]; other site 361100002872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100002873 ATP binding site [chemical binding]; other site 361100002874 Mg2+ binding site [ion binding]; other site 361100002875 G-X-G motif; other site 361100002876 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 361100002877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100002878 active site 361100002879 phosphorylation site [posttranslational modification] 361100002880 intermolecular recognition site; other site 361100002881 dimerization interface [polypeptide binding]; other site 361100002882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 361100002883 Restriction endonuclease; Region: Mrr_cat; pfam04471 361100002884 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 361100002885 Part of AAA domain; Region: AAA_19; pfam13245 361100002886 Family description; Region: UvrD_C_2; pfam13538 361100002887 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 361100002888 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 361100002889 putative metal binding site [ion binding]; other site 361100002890 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 361100002891 putative metal binding site [ion binding]; other site 361100002892 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 361100002893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 361100002894 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 361100002895 Protein of unknown function (DUF524); Region: DUF524; pfam04411 361100002896 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 361100002897 Domain of unknown function DUF87; Region: DUF87; pfam01935 361100002898 HerA helicase [Replication, recombination, and repair]; Region: COG0433 361100002899 Tic20-like protein; Region: Tic20; pfam09685 361100002900 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 361100002901 DNA binding residues [nucleotide binding] 361100002902 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100002903 dimer interface [polypeptide binding]; other site 361100002904 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 361100002905 heme uptake protein IsdB; Region: IsdB; TIGR03657 361100002906 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 361100002907 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 361100002908 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 361100002909 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 361100002910 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 361100002911 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 361100002912 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 361100002913 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 361100002914 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 361100002915 Walker A motif; other site 361100002916 ATP binding site [chemical binding]; other site 361100002917 Walker B motif; other site 361100002918 DNA binding loops [nucleotide binding] 361100002919 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 361100002920 Predicted transcriptional regulators [Transcription]; Region: COG1378 361100002921 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 361100002922 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 361100002923 C-terminal domain interface [polypeptide binding]; other site 361100002924 sugar binding site [chemical binding]; other site 361100002925 hypothetical protein; Provisional; Region: PRK10621 361100002926 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 361100002927 Predicted permease; Region: DUF318; cl17795 361100002928 Predicted permease; Region: DUF318; cl17795 361100002929 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100002930 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 361100002931 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 361100002932 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 361100002933 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 361100002934 CGNR zinc finger; Region: zf-CGNR; pfam11706 361100002935 HPP family; Region: HPP; pfam04982 361100002936 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 361100002937 Transcriptional regulators [Transcription]; Region: MarR; COG1846 361100002938 MarR family; Region: MarR_2; pfam12802 361100002939 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 361100002940 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 361100002941 ATP synthase I chain; Region: ATP_synt_I; pfam03899 361100002942 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 361100002943 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 361100002944 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 361100002945 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 361100002946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100002947 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 361100002948 dihydroxyacetone kinase; Provisional; Region: PRK14479 361100002949 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 361100002950 DAK2 domain; Region: Dak2; pfam02734 361100002951 CAAX protease self-immunity; Region: Abi; pfam02517 361100002952 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100002953 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100002954 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 361100002955 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100002956 Zn2+ binding site [ion binding]; other site 361100002957 Mg2+ binding site [ion binding]; other site 361100002958 S-layer homology domain; Region: SLH; pfam00395 361100002959 S-layer homology domain; Region: SLH; pfam00395 361100002960 S-layer homology domain; Region: SLH; pfam00395 361100002961 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 361100002962 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 361100002963 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100002964 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 361100002965 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 361100002966 S-layer homology domain; Region: SLH; pfam00395 361100002967 S-layer homology domain; Region: SLH; pfam00395 361100002968 S-layer homology domain; Region: SLH; pfam00395 361100002969 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100002970 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 361100002971 active site 361100002972 Heat induced stress protein YflT; Region: YflT; pfam11181 361100002973 CsbD-like; Region: CsbD; pfam05532 361100002974 Predicted membrane protein [Function unknown]; Region: COG2261 361100002975 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 361100002976 anti sigma factor interaction site; other site 361100002977 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 361100002978 regulatory phosphorylation site [posttranslational modification]; other site 361100002979 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 361100002980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100002981 ATP binding site [chemical binding]; other site 361100002982 Mg2+ binding site [ion binding]; other site 361100002983 G-X-G motif; other site 361100002984 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 361100002985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100002986 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 361100002987 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100002988 DNA binding residues [nucleotide binding] 361100002989 Ferritin-like domain; Region: Ferritin; pfam00210 361100002990 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 361100002991 dinuclear metal binding motif [ion binding]; other site 361100002992 Response regulator receiver domain; Region: Response_reg; pfam00072 361100002993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100002994 active site 361100002995 phosphorylation site [posttranslational modification] 361100002996 intermolecular recognition site; other site 361100002997 dimerization interface [polypeptide binding]; other site 361100002998 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 361100002999 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 361100003000 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 361100003001 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 361100003002 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 361100003003 CHASE3 domain; Region: CHASE3; pfam05227 361100003004 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 361100003005 GAF domain; Region: GAF; pfam01590 361100003006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100003007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100003008 dimer interface [polypeptide binding]; other site 361100003009 phosphorylation site [posttranslational modification] 361100003010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100003011 ATP binding site [chemical binding]; other site 361100003012 Mg2+ binding site [ion binding]; other site 361100003013 G-X-G motif; other site 361100003014 Response regulator receiver domain; Region: Response_reg; pfam00072 361100003015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100003016 active site 361100003017 phosphorylation site [posttranslational modification] 361100003018 intermolecular recognition site; other site 361100003019 dimerization interface [polypeptide binding]; other site 361100003020 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 361100003021 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 361100003022 hypothetical protein; Provisional; Region: PRK12856 361100003023 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 361100003024 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 361100003025 NADP binding site [chemical binding]; other site 361100003026 dimer interface [polypeptide binding]; other site 361100003027 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 361100003028 YhzD-like protein; Region: YhzD; pfam14120 361100003029 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 361100003030 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100003031 active site 361100003032 metal binding site [ion binding]; metal-binding site 361100003033 AAA domain; Region: AAA_27; pfam13514 361100003034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100003035 Q-loop/lid; other site 361100003036 ABC transporter signature motif; other site 361100003037 Walker B; other site 361100003038 D-loop; other site 361100003039 H-loop/switch region; other site 361100003040 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 361100003041 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 361100003042 generic binding surface II; other site 361100003043 generic binding surface I; other site 361100003044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100003045 Zn2+ binding site [ion binding]; other site 361100003046 Mg2+ binding site [ion binding]; other site 361100003047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100003048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100003049 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 361100003050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100003051 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 361100003052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100003053 Zn binding site [ion binding]; other site 361100003054 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 361100003055 Zn binding site [ion binding]; other site 361100003056 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 361100003057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100003058 Zn binding site [ion binding]; other site 361100003059 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 361100003060 Zn binding site [ion binding]; other site 361100003061 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; pfam09965 361100003062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100003063 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 361100003064 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 361100003065 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 361100003066 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 361100003067 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 361100003068 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 361100003069 amphipathic channel; other site 361100003070 Asn-Pro-Ala signature motifs; other site 361100003071 glycerol kinase; Provisional; Region: glpK; PRK00047 361100003072 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 361100003073 N- and C-terminal domain interface [polypeptide binding]; other site 361100003074 active site 361100003075 MgATP binding site [chemical binding]; other site 361100003076 catalytic site [active] 361100003077 metal binding site [ion binding]; metal-binding site 361100003078 glycerol binding site [chemical binding]; other site 361100003079 homotetramer interface [polypeptide binding]; other site 361100003080 homodimer interface [polypeptide binding]; other site 361100003081 FBP binding site [chemical binding]; other site 361100003082 protein IIAGlc interface [polypeptide binding]; other site 361100003083 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 361100003084 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 361100003085 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100003086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100003087 DNA binding residues [nucleotide binding] 361100003088 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 361100003089 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100003090 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 361100003091 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 361100003092 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 361100003093 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 361100003094 Part of AAA domain; Region: AAA_19; pfam13245 361100003095 Family description; Region: UvrD_C_2; pfam13538 361100003096 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 361100003097 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 361100003098 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 361100003099 transcriptional regulator Hpr; Provisional; Region: PRK13777 361100003100 MarR family; Region: MarR; pfam01047 361100003101 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 361100003102 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 361100003103 HIT family signature motif; other site 361100003104 catalytic residue [active] 361100003105 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 361100003106 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100003107 Walker A/P-loop; other site 361100003108 ATP binding site [chemical binding]; other site 361100003109 Q-loop/lid; other site 361100003110 ABC transporter signature motif; other site 361100003111 Walker B; other site 361100003112 D-loop; other site 361100003113 H-loop/switch region; other site 361100003114 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 361100003115 EcsC protein family; Region: EcsC; pfam12787 361100003116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100003117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100003118 Uncharacterized conserved protein [Function unknown]; Region: COG3402 361100003119 Predicted membrane protein [Function unknown]; Region: COG3428 361100003120 Bacterial PH domain; Region: DUF304; pfam03703 361100003121 Bacterial PH domain; Region: DUF304; cl01348 361100003122 Bacterial PH domain; Region: DUF304; pfam03703 361100003123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 361100003124 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 361100003125 MAEBL; Provisional; Region: PTZ00121 361100003126 Uncharacterized conserved protein [Function unknown]; Region: COG3402 361100003127 Predicted membrane protein [Function unknown]; Region: COG3428 361100003128 Bacterial PH domain; Region: DUF304; pfam03703 361100003129 Bacterial PH domain; Region: DUF304; pfam03703 361100003130 Bacterial PH domain; Region: DUF304; pfam03703 361100003131 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 361100003132 Transglycosylase; Region: Transgly; pfam00912 361100003133 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 361100003134 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100003135 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 361100003136 substrate binding site [chemical binding]; other site 361100003137 active site 361100003138 ferrochelatase; Provisional; Region: PRK12435 361100003139 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 361100003140 C-terminal domain interface [polypeptide binding]; other site 361100003141 active site 361100003142 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 361100003143 active site 361100003144 N-terminal domain interface [polypeptide binding]; other site 361100003145 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 361100003146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 361100003147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 361100003148 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 361100003149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 361100003150 Fn3 associated; Region: Fn3_assoc; pfam13287 361100003151 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 361100003152 generic binding surface II; other site 361100003153 generic binding surface I; other site 361100003154 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 361100003155 putative active site [active] 361100003156 putative catalytic site [active] 361100003157 putative Mg binding site IVb [ion binding]; other site 361100003158 putative phosphate binding site [ion binding]; other site 361100003159 putative DNA binding site [nucleotide binding]; other site 361100003160 putative Mg binding site IVa [ion binding]; other site 361100003161 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100003162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100003163 Predicted membrane protein [Function unknown]; Region: COG1511 361100003164 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 361100003165 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 361100003166 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 361100003167 trimer interface [polypeptide binding]; other site 361100003168 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 361100003169 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 361100003170 DinB superfamily; Region: DinB_2; pfam12867 361100003171 Predicted transcriptional regulator [Transcription]; Region: COG2378 361100003172 HTH domain; Region: HTH_11; pfam08279 361100003173 WYL domain; Region: WYL; pfam13280 361100003174 Transcriptional regulators [Transcription]; Region: PurR; COG1609 361100003175 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 361100003176 DNA binding site [nucleotide binding] 361100003177 domain linker motif; other site 361100003178 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 361100003179 putative dimerization interface [polypeptide binding]; other site 361100003180 putative ligand binding site [chemical binding]; other site 361100003181 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 361100003182 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 361100003183 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 361100003184 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 361100003185 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 361100003186 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 361100003187 acyl-activating enzyme (AAE) consensus motif; other site 361100003188 putative AMP binding site [chemical binding]; other site 361100003189 putative active site [active] 361100003190 putative CoA binding site [chemical binding]; other site 361100003191 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 361100003192 heme-binding site [chemical binding]; other site 361100003193 S-layer homology domain; Region: SLH; pfam00395 361100003194 S-layer homology domain; Region: SLH; pfam00395 361100003195 S-layer homology domain; Region: SLH; pfam00395 361100003196 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 361100003197 RHS Repeat; Region: RHS_repeat; pfam05593 361100003198 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 361100003199 RHS protein; Region: RHS; pfam03527 361100003200 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 361100003201 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 361100003202 RHS Repeat; Region: RHS_repeat; cl11982 361100003203 RHS protein; Region: RHS; pfam03527 361100003204 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 361100003205 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 361100003206 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 361100003207 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 361100003208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100003209 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 361100003210 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100003211 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 361100003212 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100003213 putative active site [active] 361100003214 putative metal binding site [ion binding]; other site 361100003215 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100003216 Zn2+ binding site [ion binding]; other site 361100003217 Mg2+ binding site [ion binding]; other site 361100003218 Putative zinc-finger; Region: zf-HC2; pfam13490 361100003219 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 361100003220 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 361100003221 RNA polymerase sigma factor; Provisional; Region: PRK12541 361100003222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100003223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100003224 DNA binding residues [nucleotide binding] 361100003225 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 361100003226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100003227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 361100003228 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 361100003229 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100003230 active site 361100003231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100003232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100003233 dimer interface [polypeptide binding]; other site 361100003234 phosphorylation site [posttranslational modification] 361100003235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100003236 ATP binding site [chemical binding]; other site 361100003237 Mg2+ binding site [ion binding]; other site 361100003238 G-X-G motif; other site 361100003239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100003240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100003241 active site 361100003242 phosphorylation site [posttranslational modification] 361100003243 intermolecular recognition site; other site 361100003244 dimerization interface [polypeptide binding]; other site 361100003245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100003246 DNA binding site [nucleotide binding] 361100003247 CAAX protease self-immunity; Region: Abi; pfam02517 361100003248 Peptidase family M48; Region: Peptidase_M48; pfam01435 361100003249 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 361100003250 EamA-like transporter family; Region: EamA; pfam00892 361100003251 EamA-like transporter family; Region: EamA; pfam00892 361100003252 S-layer homology domain; Region: SLH; pfam00395 361100003253 S-layer homology domain; Region: SLH; pfam00395 361100003254 S-layer homology domain; Region: SLH; pfam00395 361100003255 S-layer homology domain; Region: SLH; pfam00395 361100003256 S-layer homology domain; Region: SLH; pfam00395 361100003257 S-layer homology domain; Region: SLH; pfam00395 361100003258 S-layer homology domain; Region: SLH; pfam00395 361100003259 S-layer homology domain; Region: SLH; pfam00395 361100003260 S-layer homology domain; Region: SLH; pfam00395 361100003261 malate synthase A; Region: malate_syn_A; TIGR01344 361100003262 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 361100003263 active site 361100003264 isocitrate lyase; Provisional; Region: PRK15063 361100003265 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 361100003266 tetramer interface [polypeptide binding]; other site 361100003267 active site 361100003268 Mg2+/Mn2+ binding site [ion binding]; other site 361100003269 Phosphotransferase enzyme family; Region: APH; pfam01636 361100003270 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 361100003271 active site 361100003272 substrate binding site [chemical binding]; other site 361100003273 ATP binding site [chemical binding]; other site 361100003274 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 361100003275 DNA-binding site [nucleotide binding]; DNA binding site 361100003276 RNA-binding motif; other site 361100003277 ComK protein; Region: ComK; pfam06338 361100003278 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 361100003279 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 361100003280 Uncharacterized conserved protein [Function unknown]; Region: COG0398 361100003281 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 361100003282 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 361100003283 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 361100003284 Catalytic site [active] 361100003285 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 361100003286 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 361100003287 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 361100003288 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 361100003289 Part of AAA domain; Region: AAA_19; pfam13245 361100003290 Family description; Region: UvrD_C_2; pfam13538 361100003291 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 361100003292 hypothetical protein; Provisional; Region: PRK07758 361100003293 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 361100003294 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 361100003295 Spore germination protein GerPC; Region: GerPC; pfam10737 361100003296 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 361100003297 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 361100003298 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 361100003299 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 361100003300 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 361100003301 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 361100003302 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 361100003303 inhibitor-cofactor binding pocket; inhibition site 361100003304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100003305 catalytic residue [active] 361100003306 hypothetical protein; Provisional; Region: PRK13673 361100003307 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 361100003308 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 361100003309 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 361100003310 dimer interface [polypeptide binding]; other site 361100003311 active site 361100003312 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 361100003313 Ligand Binding Site [chemical binding]; other site 361100003314 Molecular Tunnel; other site 361100003315 ferrochelatase; Provisional; Region: PRK12435 361100003316 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 361100003317 C-terminal domain interface [polypeptide binding]; other site 361100003318 active site 361100003319 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 361100003320 active site 361100003321 N-terminal domain interface [polypeptide binding]; other site 361100003322 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 361100003323 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 361100003324 tetramer interface [polypeptide binding]; other site 361100003325 heme binding pocket [chemical binding]; other site 361100003326 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 361100003327 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 361100003328 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 361100003329 active site 361100003330 catalytic site [active] 361100003331 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100003332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100003333 non-specific DNA binding site [nucleotide binding]; other site 361100003334 salt bridge; other site 361100003335 sequence-specific DNA binding site [nucleotide binding]; other site 361100003336 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100003337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 361100003338 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 361100003339 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 361100003340 S1 domain; Region: S1_2; pfam13509 361100003341 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 361100003342 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 361100003343 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 361100003344 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 361100003345 RHS Repeat; Region: RHS_repeat; pfam05593 361100003346 RHS protein; Region: RHS; pfam03527 361100003347 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 361100003348 potential frameshift: common BLAST hit: gi|217958675|ref|YP_002337223.1| wall-associated protein 361100003349 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 361100003350 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 361100003351 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 361100003352 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100003353 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100003354 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100003355 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100003356 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 361100003357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100003358 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 361100003359 active site 361100003360 motif I; other site 361100003361 motif II; other site 361100003362 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 361100003363 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 361100003364 Clp amino terminal domain; Region: Clp_N; pfam02861 361100003365 Clp amino terminal domain; Region: Clp_N; pfam02861 361100003366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100003367 Walker A motif; other site 361100003368 ATP binding site [chemical binding]; other site 361100003369 Walker B motif; other site 361100003370 arginine finger; other site 361100003371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100003372 Walker A motif; other site 361100003373 ATP binding site [chemical binding]; other site 361100003374 Walker B motif; other site 361100003375 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 361100003376 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 361100003377 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 361100003378 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 361100003379 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 361100003380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100003381 NAD(P) binding site [chemical binding]; other site 361100003382 active site 361100003383 ComZ; Region: ComZ; pfam10815 361100003384 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 361100003385 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 361100003386 dimer interface [polypeptide binding]; other site 361100003387 active site 361100003388 CoA binding pocket [chemical binding]; other site 361100003389 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 361100003390 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 361100003391 dimer interface [polypeptide binding]; other site 361100003392 active site 361100003393 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 361100003394 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 361100003395 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 361100003396 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 361100003397 active site 361100003398 HIGH motif; other site 361100003399 dimer interface [polypeptide binding]; other site 361100003400 KMSKS motif; other site 361100003401 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 361100003402 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100003403 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100003404 peptide binding site [polypeptide binding]; other site 361100003405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 361100003406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100003407 dimer interface [polypeptide binding]; other site 361100003408 conserved gate region; other site 361100003409 putative PBP binding loops; other site 361100003410 ABC-ATPase subunit interface; other site 361100003411 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 361100003412 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 361100003413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100003414 dimer interface [polypeptide binding]; other site 361100003415 conserved gate region; other site 361100003416 putative PBP binding loops; other site 361100003417 ABC-ATPase subunit interface; other site 361100003418 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 361100003419 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100003420 Walker A/P-loop; other site 361100003421 ATP binding site [chemical binding]; other site 361100003422 Q-loop/lid; other site 361100003423 ABC transporter signature motif; other site 361100003424 Walker B; other site 361100003425 D-loop; other site 361100003426 H-loop/switch region; other site 361100003427 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 361100003428 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 361100003429 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 361100003430 Walker A/P-loop; other site 361100003431 ATP binding site [chemical binding]; other site 361100003432 Q-loop/lid; other site 361100003433 ABC transporter signature motif; other site 361100003434 Walker B; other site 361100003435 D-loop; other site 361100003436 H-loop/switch region; other site 361100003437 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 361100003438 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 361100003439 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 361100003440 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100003441 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100003442 peptide binding site [polypeptide binding]; other site 361100003443 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 361100003444 ArsC family; Region: ArsC; pfam03960 361100003445 putative catalytic residues [active] 361100003446 thiol/disulfide switch; other site 361100003447 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 361100003448 adaptor protein; Provisional; Region: PRK02315 361100003449 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 361100003450 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 361100003451 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 361100003452 putative active site [active] 361100003453 catalytic site [active] 361100003454 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 361100003455 putative active site [active] 361100003456 catalytic site [active] 361100003457 Competence protein CoiA-like family; Region: CoiA; cl11541 361100003458 oligoendopeptidase F; Region: pepF; TIGR00181 361100003459 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 361100003460 active site 361100003461 Zn binding site [ion binding]; other site 361100003462 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 361100003463 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 361100003464 catalytic residues [active] 361100003465 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 361100003466 apolar tunnel; other site 361100003467 heme binding site [chemical binding]; other site 361100003468 dimerization interface [polypeptide binding]; other site 361100003469 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 361100003470 putative active site [active] 361100003471 putative metal binding residues [ion binding]; other site 361100003472 signature motif; other site 361100003473 putative triphosphate binding site [ion binding]; other site 361100003474 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 361100003475 synthetase active site [active] 361100003476 NTP binding site [chemical binding]; other site 361100003477 metal binding site [ion binding]; metal-binding site 361100003478 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 361100003479 ATP-NAD kinase; Region: NAD_kinase; pfam01513 361100003480 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 361100003481 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 361100003482 active site 361100003483 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 361100003484 trimer interface [polypeptide binding]; other site 361100003485 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 361100003486 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 361100003487 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 361100003488 active site 361100003489 metal binding site [ion binding]; metal-binding site 361100003490 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 361100003491 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 361100003492 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 361100003493 active site 361100003494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100003495 S-adenosylmethionine binding site [chemical binding]; other site 361100003496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 361100003497 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 361100003498 putative metal binding site; other site 361100003499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100003500 binding surface 361100003501 TPR motif; other site 361100003502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 361100003503 binding surface 361100003504 TPR motif; other site 361100003505 Methyltransferase domain; Region: Methyltransf_23; pfam13489 361100003506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100003507 S-adenosylmethionine binding site [chemical binding]; other site 361100003508 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 361100003509 catalytic residues [active] 361100003510 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 361100003511 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 361100003512 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 361100003513 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 361100003514 active site 361100003515 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 361100003516 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 361100003517 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 361100003518 NAD binding site [chemical binding]; other site 361100003519 substrate binding site [chemical binding]; other site 361100003520 homodimer interface [polypeptide binding]; other site 361100003521 active site 361100003522 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 361100003523 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 361100003524 NADP binding site [chemical binding]; other site 361100003525 active site 361100003526 putative substrate binding site [chemical binding]; other site 361100003527 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 361100003528 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 361100003529 NAD binding site [chemical binding]; other site 361100003530 homotetramer interface [polypeptide binding]; other site 361100003531 homodimer interface [polypeptide binding]; other site 361100003532 substrate binding site [chemical binding]; other site 361100003533 active site 361100003534 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 361100003535 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 361100003536 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 361100003537 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 361100003538 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 361100003539 Part of AAA domain; Region: AAA_19; pfam13245 361100003540 Family description; Region: UvrD_C_2; pfam13538 361100003541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 361100003542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100003543 Coenzyme A binding pocket [chemical binding]; other site 361100003544 hypothetical protein; Provisional; Region: PRK13679 361100003545 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 361100003546 Putative esterase; Region: Esterase; pfam00756 361100003547 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 361100003548 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 361100003549 EamA-like transporter family; Region: EamA; pfam00892 361100003550 EamA-like transporter family; Region: EamA; pfam00892 361100003551 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 361100003552 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 361100003553 Pectate lyase; Region: Pectate_lyase; pfam03211 361100003554 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 361100003555 Na binding site [ion binding]; other site 361100003556 anthranilate synthase component I; Provisional; Region: PRK13570 361100003557 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 361100003558 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 361100003559 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 361100003560 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 361100003561 glutamine binding [chemical binding]; other site 361100003562 catalytic triad [active] 361100003563 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 361100003564 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 361100003565 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 361100003566 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 361100003567 active site 361100003568 ribulose/triose binding site [chemical binding]; other site 361100003569 phosphate binding site [ion binding]; other site 361100003570 substrate (anthranilate) binding pocket [chemical binding]; other site 361100003571 product (indole) binding pocket [chemical binding]; other site 361100003572 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 361100003573 active site 361100003574 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 361100003575 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 361100003576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100003577 catalytic residue [active] 361100003578 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 361100003579 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 361100003580 substrate binding site [chemical binding]; other site 361100003581 active site 361100003582 catalytic residues [active] 361100003583 heterodimer interface [polypeptide binding]; other site 361100003584 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 361100003585 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 361100003586 L-lactate permease; Region: Lactate_perm; cl00701 361100003587 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 361100003588 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 361100003589 catalytic residues [active] 361100003590 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 361100003591 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 361100003592 Double zinc ribbon; Region: DZR; pfam12773 361100003593 YARHG domain; Region: YARHG; pfam13308 361100003594 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 361100003595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 361100003596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100003597 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 361100003598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100003599 Coenzyme A binding pocket [chemical binding]; other site 361100003600 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 361100003601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100003602 S-adenosylmethionine binding site [chemical binding]; other site 361100003603 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 361100003604 NADPH bind site [chemical binding]; other site 361100003605 putative FMN binding site [chemical binding]; other site 361100003606 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 361100003607 putative FMN binding site [chemical binding]; other site 361100003608 NADPH bind site [chemical binding]; other site 361100003609 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 361100003610 YcaO-like family; Region: YcaO; pfam02624 361100003611 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 361100003612 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 361100003613 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 361100003614 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 361100003615 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 361100003616 E3 interaction surface; other site 361100003617 lipoyl attachment site [posttranslational modification]; other site 361100003618 e3 binding domain; Region: E3_binding; pfam02817 361100003619 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 361100003620 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 361100003621 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 361100003622 TPP-binding site [chemical binding]; other site 361100003623 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 361100003624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100003625 salt bridge; other site 361100003626 non-specific DNA binding site [nucleotide binding]; other site 361100003627 sequence-specific DNA binding site [nucleotide binding]; other site 361100003628 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 361100003629 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 361100003630 Probable transposase; Region: OrfB_IS605; pfam01385 361100003631 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 361100003632 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 361100003633 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 361100003634 active site 361100003635 catalytic residues [active] 361100003636 Int/Topo IB signature motif; other site 361100003637 DNA binding site [nucleotide binding] 361100003638 Protein of unknown function (DUF1411); Region: DUF1411; pfam07199 361100003639 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100003640 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 361100003641 Presynaptic Site I dimer interface [polypeptide binding]; other site 361100003642 catalytic residues [active] 361100003643 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 361100003644 Synaptic Flat tetramer interface [polypeptide binding]; other site 361100003645 Synaptic Site I dimer interface [polypeptide binding]; other site 361100003646 DNA binding site [nucleotide binding] 361100003647 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 361100003648 integrase; Provisional; Region: int; PHA02601 361100003649 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 361100003650 Int/Topo IB signature motif; other site 361100003651 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 361100003652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100003653 S-adenosylmethionine binding site [chemical binding]; other site 361100003654 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 361100003655 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100003656 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 361100003657 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 361100003658 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 361100003659 Catalytic site [active] 361100003660 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 361100003661 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 361100003662 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 361100003663 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100003664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100003665 non-specific DNA binding site [nucleotide binding]; other site 361100003666 salt bridge; other site 361100003667 sequence-specific DNA binding site [nucleotide binding]; other site 361100003668 Anti-repressor SinI; Region: SinI; pfam08671 361100003669 Anti-repressor SinI; Region: SinI; pfam08671 361100003670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 361100003671 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 361100003672 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 361100003673 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 361100003674 NAD(P) binding site [chemical binding]; other site 361100003675 catalytic residues [active] 361100003676 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 361100003677 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 361100003678 Walker A/P-loop; other site 361100003679 ATP binding site [chemical binding]; other site 361100003680 Q-loop/lid; other site 361100003681 ABC transporter signature motif; other site 361100003682 Walker B; other site 361100003683 D-loop; other site 361100003684 H-loop/switch region; other site 361100003685 TOBE domain; Region: TOBE_2; pfam08402 361100003686 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 361100003687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100003688 dimer interface [polypeptide binding]; other site 361100003689 conserved gate region; other site 361100003690 putative PBP binding loops; other site 361100003691 ABC-ATPase subunit interface; other site 361100003692 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 361100003693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100003694 dimer interface [polypeptide binding]; other site 361100003695 conserved gate region; other site 361100003696 putative PBP binding loops; other site 361100003697 ABC-ATPase subunit interface; other site 361100003698 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 361100003699 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 361100003700 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 361100003701 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 361100003702 active site 361100003703 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 361100003704 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 361100003705 ABC-2 type transporter; Region: ABC2_membrane; cl17235 361100003706 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 361100003707 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 361100003708 active site 361100003709 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 361100003710 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 361100003711 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 361100003712 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 361100003713 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 361100003714 Cysteine-rich domain; Region: CCG; pfam02754 361100003715 Cysteine-rich domain; Region: CCG; pfam02754 361100003716 FAD binding domain; Region: FAD_binding_4; pfam01565 361100003717 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 361100003718 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 361100003719 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 361100003720 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 361100003721 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 361100003722 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 361100003723 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100003724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100003725 active site 361100003726 phosphorylation site [posttranslational modification] 361100003727 intermolecular recognition site; other site 361100003728 dimerization interface [polypeptide binding]; other site 361100003729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100003730 DNA binding site [nucleotide binding] 361100003731 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 361100003732 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100003733 dimerization interface [polypeptide binding]; other site 361100003734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100003735 dimer interface [polypeptide binding]; other site 361100003736 phosphorylation site [posttranslational modification] 361100003737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100003738 ATP binding site [chemical binding]; other site 361100003739 Mg2+ binding site [ion binding]; other site 361100003740 G-X-G motif; other site 361100003741 Transcriptional regulators [Transcription]; Region: FadR; COG2186 361100003742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100003743 DNA-binding site [nucleotide binding]; DNA binding site 361100003744 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 361100003745 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 361100003746 Cysteine-rich domain; Region: CCG; pfam02754 361100003747 Cysteine-rich domain; Region: CCG; pfam02754 361100003748 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 361100003749 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 361100003750 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 361100003751 Uncharacterized conserved protein [Function unknown]; Region: COG1556 361100003752 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 361100003753 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 361100003754 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 361100003755 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 361100003756 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 361100003757 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 361100003758 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 361100003759 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 361100003760 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 361100003761 dimer interaction site [polypeptide binding]; other site 361100003762 substrate-binding tunnel; other site 361100003763 active site 361100003764 catalytic site [active] 361100003765 substrate binding site [chemical binding]; other site 361100003766 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 361100003767 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 361100003768 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100003769 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 361100003770 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 361100003771 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 361100003772 NAD(P) binding site [chemical binding]; other site 361100003773 homotetramer interface [polypeptide binding]; other site 361100003774 homodimer interface [polypeptide binding]; other site 361100003775 active site 361100003776 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 361100003777 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 361100003778 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 361100003779 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 361100003780 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 361100003781 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 361100003782 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 361100003783 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 361100003784 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 361100003785 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 361100003786 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 361100003787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100003788 Walker A/P-loop; other site 361100003789 ATP binding site [chemical binding]; other site 361100003790 Q-loop/lid; other site 361100003791 ABC transporter signature motif; other site 361100003792 Walker B; other site 361100003793 D-loop; other site 361100003794 H-loop/switch region; other site 361100003795 TOBE domain; Region: TOBE_2; pfam08402 361100003796 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 361100003797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100003798 dimer interface [polypeptide binding]; other site 361100003799 conserved gate region; other site 361100003800 putative PBP binding loops; other site 361100003801 ABC-ATPase subunit interface; other site 361100003802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100003803 dimer interface [polypeptide binding]; other site 361100003804 conserved gate region; other site 361100003805 putative PBP binding loops; other site 361100003806 ABC-ATPase subunit interface; other site 361100003807 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 361100003808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100003809 motif II; other site 361100003810 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 361100003811 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100003812 catalytic residue [active] 361100003813 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 361100003814 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 361100003815 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 361100003816 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 361100003817 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 361100003818 heme-binding site [chemical binding]; other site 361100003819 Leucine rich repeat; Region: LRR_8; pfam13855 361100003820 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 361100003821 Leucine-rich repeats; other site 361100003822 Leucine rich repeat; Region: LRR_8; pfam13855 361100003823 Substrate binding site [chemical binding]; other site 361100003824 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100003825 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100003826 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100003827 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 361100003828 S-layer homology domain; Region: SLH; pfam00395 361100003829 S-layer homology domain; Region: SLH; pfam00395 361100003830 S-layer homology domain; Region: SLH; pfam00395 361100003831 hypothetical protein; Validated; Region: PRK06755 361100003832 intersubunit interface [polypeptide binding]; other site 361100003833 active site 361100003834 Zn2+ binding site [ion binding]; other site 361100003835 FOG: CBS domain [General function prediction only]; Region: COG0517 361100003836 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 361100003837 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 361100003838 NodB motif; other site 361100003839 putative active site [active] 361100003840 putative catalytic site [active] 361100003841 Zn binding site [ion binding]; other site 361100003842 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 361100003843 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 361100003844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100003845 dimer interface [polypeptide binding]; other site 361100003846 phosphorylation site [posttranslational modification] 361100003847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100003848 ATP binding site [chemical binding]; other site 361100003849 Mg2+ binding site [ion binding]; other site 361100003850 G-X-G motif; other site 361100003851 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100003852 MarR family; Region: MarR; pfam01047 361100003853 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 361100003854 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 361100003855 active site 361100003856 Zn binding site [ion binding]; other site 361100003857 DinB superfamily; Region: DinB_2; pfam12867 361100003858 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 361100003859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100003860 dimer interface [polypeptide binding]; other site 361100003861 phosphorylation site [posttranslational modification] 361100003862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100003863 ATP binding site [chemical binding]; other site 361100003864 Mg2+ binding site [ion binding]; other site 361100003865 G-X-G motif; other site 361100003866 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 361100003867 Ligand Binding Site [chemical binding]; other site 361100003868 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 361100003869 active site 361100003870 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 361100003871 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 361100003872 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 361100003873 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 361100003874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100003875 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 361100003876 Coenzyme A binding pocket [chemical binding]; other site 361100003877 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 361100003878 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 361100003879 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 361100003880 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 361100003881 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 361100003882 dimer interface [polypeptide binding]; other site 361100003883 putative radical transfer pathway; other site 361100003884 diiron center [ion binding]; other site 361100003885 tyrosyl radical; other site 361100003886 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 361100003887 catalytic site [active] 361100003888 metal binding site [ion binding]; metal-binding site 361100003889 Homeodomain-like domain; Region: HTH_23; pfam13384 361100003890 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 361100003891 Predicted transcriptional regulators [Transcription]; Region: COG1725 361100003892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100003893 DNA-binding site [nucleotide binding]; DNA binding site 361100003894 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 361100003895 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100003896 Walker A/P-loop; other site 361100003897 ATP binding site [chemical binding]; other site 361100003898 Q-loop/lid; other site 361100003899 ABC transporter signature motif; other site 361100003900 Walker B; other site 361100003901 D-loop; other site 361100003902 H-loop/switch region; other site 361100003903 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100003904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100003905 Walker A/P-loop; other site 361100003906 ATP binding site [chemical binding]; other site 361100003907 Q-loop/lid; other site 361100003908 ABC transporter signature motif; other site 361100003909 Walker B; other site 361100003910 D-loop; other site 361100003911 H-loop/switch region; other site 361100003912 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 361100003913 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 361100003914 CAAX protease self-immunity; Region: Abi; pfam02517 361100003915 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 361100003916 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 361100003917 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 361100003918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100003919 putative DNA binding site [nucleotide binding]; other site 361100003920 putative Zn2+ binding site [ion binding]; other site 361100003921 AsnC family; Region: AsnC_trans_reg; pfam01037 361100003922 Uncharacterized conserved protein [Function unknown]; Region: COG2128 361100003923 Isochorismatase family; Region: Isochorismatase; pfam00857 361100003924 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 361100003925 catalytic triad [active] 361100003926 conserved cis-peptide bond; other site 361100003927 SseB protein; Region: SseB; cl06279 361100003928 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 361100003929 dimer interface [polypeptide binding]; other site 361100003930 catalytic triad [active] 361100003931 Nitronate monooxygenase; Region: NMO; pfam03060 361100003932 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 361100003933 FMN binding site [chemical binding]; other site 361100003934 substrate binding site [chemical binding]; other site 361100003935 putative catalytic residue [active] 361100003936 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 361100003937 DltD N-terminal region; Region: DltD_N; pfam04915 361100003938 DltD central region; Region: DltD_M; pfam04918 361100003939 DltD C-terminal region; Region: DltD_C; pfam04914 361100003940 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 361100003941 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 361100003942 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 361100003943 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 361100003944 acyl-activating enzyme (AAE) consensus motif; other site 361100003945 AMP binding site [chemical binding]; other site 361100003946 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 361100003947 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 361100003948 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 361100003949 metal binding site [ion binding]; metal-binding site 361100003950 dimer interface [polypeptide binding]; other site 361100003951 flavodoxin; Provisional; Region: PRK06756 361100003952 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 361100003953 Phosphotransferase enzyme family; Region: APH; pfam01636 361100003954 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 361100003955 active site 361100003956 substrate binding site [chemical binding]; other site 361100003957 ATP binding site [chemical binding]; other site 361100003958 multidrug efflux protein; Reviewed; Region: PRK01766 361100003959 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 361100003960 cation binding site [ion binding]; other site 361100003961 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 361100003962 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 361100003963 catalytic residues [active] 361100003964 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100003965 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 361100003966 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 361100003967 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 361100003968 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 361100003969 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 361100003970 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 361100003971 hypothetical protein; Provisional; Region: PRK03094 361100003972 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 361100003973 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 361100003974 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 361100003975 homodimer interface [polypeptide binding]; other site 361100003976 substrate-cofactor binding pocket; other site 361100003977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100003978 catalytic residue [active] 361100003979 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 361100003980 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 361100003981 PYR/PP interface [polypeptide binding]; other site 361100003982 dimer interface [polypeptide binding]; other site 361100003983 TPP binding site [chemical binding]; other site 361100003984 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 361100003985 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 361100003986 TPP-binding site [chemical binding]; other site 361100003987 dimer interface [polypeptide binding]; other site 361100003988 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 361100003989 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 361100003990 putative valine binding site [chemical binding]; other site 361100003991 dimer interface [polypeptide binding]; other site 361100003992 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 361100003993 ketol-acid reductoisomerase; Provisional; Region: PRK05479 361100003994 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 361100003995 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 361100003996 2-isopropylmalate synthase; Validated; Region: PRK00915 361100003997 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 361100003998 active site 361100003999 catalytic residues [active] 361100004000 metal binding site [ion binding]; metal-binding site 361100004001 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 361100004002 tartrate dehydrogenase; Region: TTC; TIGR02089 361100004003 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 361100004004 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 361100004005 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 361100004006 substrate binding site [chemical binding]; other site 361100004007 ligand binding site [chemical binding]; other site 361100004008 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 361100004009 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 361100004010 substrate binding site [chemical binding]; other site 361100004011 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 361100004012 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 361100004013 dimer interface [polypeptide binding]; other site 361100004014 motif 1; other site 361100004015 active site 361100004016 motif 2; other site 361100004017 motif 3; other site 361100004018 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 361100004019 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 361100004020 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 361100004021 histidinol dehydrogenase; Region: hisD; TIGR00069 361100004022 NAD binding site [chemical binding]; other site 361100004023 dimerization interface [polypeptide binding]; other site 361100004024 product binding site; other site 361100004025 substrate binding site [chemical binding]; other site 361100004026 zinc binding site [ion binding]; other site 361100004027 catalytic residues [active] 361100004028 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 361100004029 putative active site pocket [active] 361100004030 4-fold oligomerization interface [polypeptide binding]; other site 361100004031 metal binding residues [ion binding]; metal-binding site 361100004032 3-fold/trimer interface [polypeptide binding]; other site 361100004033 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 361100004034 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 361100004035 putative active site [active] 361100004036 oxyanion strand; other site 361100004037 catalytic triad [active] 361100004038 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 361100004039 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 361100004040 catalytic residues [active] 361100004041 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 361100004042 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 361100004043 substrate binding site [chemical binding]; other site 361100004044 glutamase interaction surface [polypeptide binding]; other site 361100004045 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 361100004046 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 361100004047 metal binding site [ion binding]; metal-binding site 361100004048 histidinol-phosphatase; Validated; Region: PRK06740 361100004049 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 361100004050 dimer interface [polypeptide binding]; other site 361100004051 active site 361100004052 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 361100004053 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 361100004054 NAD binding site [chemical binding]; other site 361100004055 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 361100004056 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 361100004057 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 361100004058 Sulfatase; Region: Sulfatase; pfam00884 361100004059 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 361100004060 diaminopimelate decarboxylase; Region: lysA; TIGR01048 361100004061 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 361100004062 active site 361100004063 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 361100004064 substrate binding site [chemical binding]; other site 361100004065 catalytic residues [active] 361100004066 dimer interface [polypeptide binding]; other site 361100004067 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 361100004068 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 361100004069 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 361100004070 Active Sites [active] 361100004071 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 361100004072 ATP-sulfurylase; Region: ATPS; cd00517 361100004073 active site 361100004074 HXXH motif; other site 361100004075 flexible loop; other site 361100004076 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 361100004077 AAA domain; Region: AAA_18; pfam13238 361100004078 ligand-binding site [chemical binding]; other site 361100004079 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 361100004080 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 361100004081 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 361100004082 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 361100004083 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 361100004084 diphthine synthase; Region: dph5; TIGR00522 361100004085 active site 361100004086 SAM binding site [chemical binding]; other site 361100004087 homodimer interface [polypeptide binding]; other site 361100004088 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 361100004089 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 361100004090 putative active site [active] 361100004091 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 361100004092 putative active site [active] 361100004093 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 361100004094 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 361100004095 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 361100004096 Na2 binding site [ion binding]; other site 361100004097 putative substrate binding site 1 [chemical binding]; other site 361100004098 Na binding site 1 [ion binding]; other site 361100004099 putative substrate binding site 2 [chemical binding]; other site 361100004100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 361100004101 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 361100004102 Peptidase family M23; Region: Peptidase_M23; pfam01551 361100004103 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 361100004104 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 361100004105 Protein of unknown function (DUF402); Region: DUF402; cl00979 361100004106 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 361100004107 Vpu protein; Region: Vpu; pfam00558 361100004108 PspA/IM30 family; Region: PspA_IM30; pfam04012 361100004109 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 361100004110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 361100004111 Histidine kinase; Region: HisKA_3; pfam07730 361100004112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100004113 ATP binding site [chemical binding]; other site 361100004114 Mg2+ binding site [ion binding]; other site 361100004115 G-X-G motif; other site 361100004116 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100004117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100004118 active site 361100004119 phosphorylation site [posttranslational modification] 361100004120 intermolecular recognition site; other site 361100004121 dimerization interface [polypeptide binding]; other site 361100004122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100004123 DNA binding residues [nucleotide binding] 361100004124 dimerization interface [polypeptide binding]; other site 361100004125 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 361100004126 E3 interaction surface; other site 361100004127 lipoyl attachment site [posttranslational modification]; other site 361100004128 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 361100004129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100004130 S-adenosylmethionine binding site [chemical binding]; other site 361100004131 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 361100004132 Peptidase family M50; Region: Peptidase_M50; pfam02163 361100004133 active site 361100004134 putative substrate binding region [chemical binding]; other site 361100004135 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 361100004136 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 361100004137 heme-binding site [chemical binding]; other site 361100004138 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 361100004139 FAD binding pocket [chemical binding]; other site 361100004140 FAD binding motif [chemical binding]; other site 361100004141 phosphate binding motif [ion binding]; other site 361100004142 beta-alpha-beta structure motif; other site 361100004143 NAD binding pocket [chemical binding]; other site 361100004144 Heme binding pocket [chemical binding]; other site 361100004145 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 361100004146 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 361100004147 ligand binding site [chemical binding]; other site 361100004148 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 361100004149 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 361100004150 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 361100004151 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 361100004152 Transglycosylase; Region: Transgly; pfam00912 361100004153 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 361100004154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100004155 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 361100004156 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 361100004157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100004158 putative active site [active] 361100004159 heme pocket [chemical binding]; other site 361100004160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100004161 dimer interface [polypeptide binding]; other site 361100004162 phosphorylation site [posttranslational modification] 361100004163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100004164 ATP binding site [chemical binding]; other site 361100004165 Mg2+ binding site [ion binding]; other site 361100004166 G-X-G motif; other site 361100004167 Protein of unknown function DUF72; Region: DUF72; pfam01904 361100004168 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 361100004169 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 361100004170 active site 361100004171 DNA binding site [nucleotide binding] 361100004172 Int/Topo IB signature motif; other site 361100004173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100004174 dimerization interface [polypeptide binding]; other site 361100004175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100004176 dimer interface [polypeptide binding]; other site 361100004177 phosphorylation site [posttranslational modification] 361100004178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100004179 ATP binding site [chemical binding]; other site 361100004180 Mg2+ binding site [ion binding]; other site 361100004181 G-X-G motif; other site 361100004182 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 361100004183 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 361100004184 Predicted integral membrane protein [Function unknown]; Region: COG0392 361100004185 Uncharacterized conserved protein [Function unknown]; Region: COG2898 361100004186 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 361100004187 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 361100004188 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 361100004189 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 361100004190 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 361100004191 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100004192 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 361100004193 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 361100004194 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 361100004195 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 361100004196 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100004197 RNA binding surface [nucleotide binding]; other site 361100004198 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 361100004199 active site 361100004200 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 361100004201 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 361100004202 catalytic residues [active] 361100004203 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 361100004204 ResB-like family; Region: ResB; pfam05140 361100004205 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 361100004206 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 361100004207 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100004208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100004209 active site 361100004210 phosphorylation site [posttranslational modification] 361100004211 intermolecular recognition site; other site 361100004212 dimerization interface [polypeptide binding]; other site 361100004213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100004214 DNA binding site [nucleotide binding] 361100004215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 361100004216 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100004217 dimerization interface [polypeptide binding]; other site 361100004218 PAS domain; Region: PAS; smart00091 361100004219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100004220 dimer interface [polypeptide binding]; other site 361100004221 phosphorylation site [posttranslational modification] 361100004222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100004223 ATP binding site [chemical binding]; other site 361100004224 Mg2+ binding site [ion binding]; other site 361100004225 G-X-G motif; other site 361100004226 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 361100004227 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 361100004228 Peptidase family M23; Region: Peptidase_M23; pfam01551 361100004229 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 361100004230 Predicted membrane protein [Function unknown]; Region: COG3601 361100004231 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 361100004232 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 361100004233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 361100004234 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 361100004235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100004236 putative Mg++ binding site [ion binding]; other site 361100004237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100004238 nucleotide binding region [chemical binding]; other site 361100004239 ATP-binding site [chemical binding]; other site 361100004240 CAAX protease self-immunity; Region: Abi; pfam02517 361100004241 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 361100004242 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 361100004243 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100004244 putative active site [active] 361100004245 putative metal binding site [ion binding]; other site 361100004246 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 361100004247 B12 binding domain; Region: B12-binding_2; pfam02607 361100004248 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 361100004249 adaptor protein; Provisional; Region: PRK02899 361100004250 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 361100004251 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 361100004252 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 361100004253 NAD(P) binding site [chemical binding]; other site 361100004254 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 361100004255 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 361100004256 amidase catalytic site [active] 361100004257 Zn binding residues [ion binding]; other site 361100004258 substrate binding site [chemical binding]; other site 361100004259 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 361100004260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 361100004261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100004262 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 361100004263 active site 361100004264 homodimer interface [polypeptide binding]; other site 361100004265 homotetramer interface [polypeptide binding]; other site 361100004266 cytidylate kinase; Provisional; Region: cmk; PRK00023 361100004267 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 361100004268 CMP-binding site; other site 361100004269 The sites determining sugar specificity; other site 361100004270 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 361100004271 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 361100004272 RNA binding site [nucleotide binding]; other site 361100004273 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 361100004274 RNA binding site [nucleotide binding]; other site 361100004275 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 361100004276 RNA binding site [nucleotide binding]; other site 361100004277 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 361100004278 RNA binding site [nucleotide binding]; other site 361100004279 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 361100004280 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 361100004281 homotetramer interface [polypeptide binding]; other site 361100004282 FMN binding site [chemical binding]; other site 361100004283 homodimer contacts [polypeptide binding]; other site 361100004284 putative active site [active] 361100004285 putative substrate binding site [chemical binding]; other site 361100004286 YIEGIA protein; Region: YIEGIA; pfam14045 361100004287 GTP-binding protein Der; Reviewed; Region: PRK00093 361100004288 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 361100004289 G1 box; other site 361100004290 GTP/Mg2+ binding site [chemical binding]; other site 361100004291 Switch I region; other site 361100004292 G2 box; other site 361100004293 Switch II region; other site 361100004294 G3 box; other site 361100004295 G4 box; other site 361100004296 G5 box; other site 361100004297 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 361100004298 G1 box; other site 361100004299 GTP/Mg2+ binding site [chemical binding]; other site 361100004300 Switch I region; other site 361100004301 G2 box; other site 361100004302 G3 box; other site 361100004303 Switch II region; other site 361100004304 G4 box; other site 361100004305 G5 box; other site 361100004306 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 361100004307 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 361100004308 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 361100004309 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 361100004310 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 361100004311 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 361100004312 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 361100004313 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 361100004314 IHF dimer interface [polypeptide binding]; other site 361100004315 IHF - DNA interface [nucleotide binding]; other site 361100004316 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 361100004317 homodecamer interface [polypeptide binding]; other site 361100004318 GTP cyclohydrolase I; Provisional; Region: PLN03044 361100004319 active site 361100004320 putative catalytic site residues [active] 361100004321 zinc binding site [ion binding]; other site 361100004322 GTP-CH-I/GFRP interaction surface; other site 361100004323 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 361100004324 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 361100004325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100004326 S-adenosylmethionine binding site [chemical binding]; other site 361100004327 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 361100004328 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 361100004329 substrate binding pocket [chemical binding]; other site 361100004330 chain length determination region; other site 361100004331 substrate-Mg2+ binding site; other site 361100004332 catalytic residues [active] 361100004333 aspartate-rich region 1; other site 361100004334 active site lid residues [active] 361100004335 aspartate-rich region 2; other site 361100004336 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 361100004337 active site 361100004338 multimer interface [polypeptide binding]; other site 361100004339 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 361100004340 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 361100004341 Tetramer interface [polypeptide binding]; other site 361100004342 active site 361100004343 FMN-binding site [chemical binding]; other site 361100004344 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 361100004345 active site 361100004346 dimer interface [polypeptide binding]; other site 361100004347 metal binding site [ion binding]; metal-binding site 361100004348 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 361100004349 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100004350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100004351 homodimer interface [polypeptide binding]; other site 361100004352 catalytic residue [active] 361100004353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100004354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100004355 binding surface 361100004356 TPR motif; other site 361100004357 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 361100004358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100004359 binding surface 361100004360 TPR motif; other site 361100004361 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100004362 TPR repeat; Region: TPR_11; pfam13414 361100004363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100004364 binding surface 361100004365 TPR motif; other site 361100004366 hypothetical protein; Provisional; Region: PRK03636 361100004367 UPF0302 domain; Region: UPF0302; pfam08864 361100004368 IDEAL domain; Region: IDEAL; pfam08858 361100004369 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 361100004370 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 361100004371 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 361100004372 iron-sulfur cluster [ion binding]; other site 361100004373 [2Fe-2S] cluster binding site [ion binding]; other site 361100004374 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 361100004375 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 361100004376 interchain domain interface [polypeptide binding]; other site 361100004377 intrachain domain interface; other site 361100004378 heme bH binding site [chemical binding]; other site 361100004379 Qi binding site; other site 361100004380 heme bL binding site [chemical binding]; other site 361100004381 Qo binding site; other site 361100004382 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 361100004383 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 361100004384 interchain domain interface [polypeptide binding]; other site 361100004385 intrachain domain interface; other site 361100004386 Qi binding site; other site 361100004387 Qo binding site; other site 361100004388 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 361100004389 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 361100004390 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 361100004391 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 361100004392 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 361100004393 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 361100004394 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 361100004395 active site 361100004396 Fe-S cluster binding site [ion binding]; other site 361100004397 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100004398 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100004399 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100004400 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100004401 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 361100004402 homodimer interface [polypeptide binding]; other site 361100004403 metal binding site [ion binding]; metal-binding site 361100004404 dihydrodipicolinate reductase; Provisional; Region: PRK00048 361100004405 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 361100004406 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 361100004407 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 361100004408 active site 361100004409 dimer interfaces [polypeptide binding]; other site 361100004410 catalytic residues [active] 361100004411 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 361100004412 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 361100004413 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 361100004414 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 361100004415 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 361100004416 active site 361100004417 NTP binding site [chemical binding]; other site 361100004418 metal binding triad [ion binding]; metal-binding site 361100004419 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 361100004420 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 361100004421 Biotin operon repressor [Transcription]; Region: BirA; COG1654 361100004422 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 361100004423 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 361100004424 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 361100004425 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 361100004426 active site 361100004427 oligomerization interface [polypeptide binding]; other site 361100004428 metal binding site [ion binding]; metal-binding site 361100004429 pantoate--beta-alanine ligase; Region: panC; TIGR00018 361100004430 Pantoate-beta-alanine ligase; Region: PanC; cd00560 361100004431 active site 361100004432 ATP-binding site [chemical binding]; other site 361100004433 pantoate-binding site; other site 361100004434 HXXH motif; other site 361100004435 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 361100004436 tetramerization interface [polypeptide binding]; other site 361100004437 active site 361100004438 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 361100004439 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 361100004440 active site 361100004441 catalytic site [active] 361100004442 substrate binding site [chemical binding]; other site 361100004443 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 361100004444 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 361100004445 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 361100004446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 361100004447 aspartate aminotransferase; Provisional; Region: PRK05764 361100004448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100004449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100004450 homodimer interface [polypeptide binding]; other site 361100004451 catalytic residue [active] 361100004452 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 361100004453 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 361100004454 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 361100004455 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 361100004456 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 361100004457 minor groove reading motif; other site 361100004458 helix-hairpin-helix signature motif; other site 361100004459 substrate binding pocket [chemical binding]; other site 361100004460 active site 361100004461 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 361100004462 Transglycosylase; Region: Transgly; pfam00912 361100004463 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 361100004464 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 361100004465 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 361100004466 Interdomain contacts; other site 361100004467 Cytokine receptor motif; other site 361100004468 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 361100004469 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 361100004470 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 361100004471 YppF-like protein; Region: YppF; pfam14178 361100004472 YppG-like protein; Region: YppG; pfam14179 361100004473 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 361100004474 hypothetical protein; Provisional; Region: PRK13660 361100004475 cell division protein GpsB; Provisional; Region: PRK14127 361100004476 DivIVA domain; Region: DivI1A_domain; TIGR03544 361100004477 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 361100004478 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 361100004479 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 361100004480 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 361100004481 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 361100004482 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 361100004483 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 361100004484 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 361100004485 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 361100004486 active site 361100004487 Zn binding site [ion binding]; other site 361100004488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100004489 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100004490 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 361100004491 active site 361100004492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100004493 active site 361100004494 xanthine permease; Region: pbuX; TIGR03173 361100004495 Predicted membrane protein [Function unknown]; Region: COG2311 361100004496 Protein of unknown function (DUF418); Region: DUF418; cl12135 361100004497 Protein of unknown function (DUF418); Region: DUF418; pfam04235 361100004498 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 361100004499 Dynamin family; Region: Dynamin_N; pfam00350 361100004500 G1 box; other site 361100004501 GTP/Mg2+ binding site [chemical binding]; other site 361100004502 G2 box; other site 361100004503 Switch I region; other site 361100004504 G3 box; other site 361100004505 Switch II region; other site 361100004506 G4 box; other site 361100004507 G5 box; other site 361100004508 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 361100004509 Dynamin family; Region: Dynamin_N; pfam00350 361100004510 G1 box; other site 361100004511 GTP/Mg2+ binding site [chemical binding]; other site 361100004512 G2 box; other site 361100004513 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 361100004514 G3 box; other site 361100004515 Switch II region; other site 361100004516 GTP/Mg2+ binding site [chemical binding]; other site 361100004517 G4 box; other site 361100004518 G5 box; other site 361100004519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100004520 Coenzyme A binding pocket [chemical binding]; other site 361100004521 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 361100004522 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 361100004523 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 361100004524 active site residue [active] 361100004525 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 361100004526 active site residue [active] 361100004527 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 361100004528 Predicted membrane protein [Function unknown]; Region: COG3766 361100004529 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 361100004530 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 361100004531 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 361100004532 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 361100004533 5'-3' exonuclease; Region: 53EXOc; smart00475 361100004534 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 361100004535 active site 361100004536 metal binding site 1 [ion binding]; metal-binding site 361100004537 putative 5' ssDNA interaction site; other site 361100004538 metal binding site 3; metal-binding site 361100004539 metal binding site 2 [ion binding]; metal-binding site 361100004540 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 361100004541 putative DNA binding site [nucleotide binding]; other site 361100004542 putative metal binding site [ion binding]; other site 361100004543 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 361100004544 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004545 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004546 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004547 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004548 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004549 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004550 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004551 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004552 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004553 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004554 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004555 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004556 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004557 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004558 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004559 Domain of unknown function DUF11; Region: DUF11; cl17728 361100004560 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004561 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004562 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004563 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004564 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004565 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004566 Domain of unknown function DUF11; Region: DUF11; cl17728 361100004567 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004568 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100004569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100004570 Coenzyme A binding pocket [chemical binding]; other site 361100004571 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 361100004572 Isochorismatase family; Region: Isochorismatase; pfam00857 361100004573 catalytic triad [active] 361100004574 conserved cis-peptide bond; other site 361100004575 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100004576 EamA-like transporter family; Region: EamA; pfam00892 361100004577 EamA-like transporter family; Region: EamA; pfam00892 361100004578 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 361100004579 RNA/DNA hybrid binding site [nucleotide binding]; other site 361100004580 active site 361100004581 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 361100004582 active site 361100004583 catalytic residues [active] 361100004584 QueT transporter; Region: QueT; pfam06177 361100004585 hypothetical protein; Validated; Region: PRK07708 361100004586 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 361100004587 RNA/DNA hybrid binding site [nucleotide binding]; other site 361100004588 active site 361100004589 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 361100004590 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 361100004591 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 361100004592 DNA-binding site [nucleotide binding]; DNA binding site 361100004593 RNA-binding motif; other site 361100004594 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 361100004595 LysE type translocator; Region: LysE; pfam01810 361100004596 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 361100004597 Protein of unknown function, DUF485; Region: DUF485; pfam04341 361100004598 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 361100004599 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 361100004600 Na binding site [ion binding]; other site 361100004601 aminotransferase; Validated; Region: PRK07678 361100004602 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 361100004603 inhibitor-cofactor binding pocket; inhibition site 361100004604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100004605 catalytic residue [active] 361100004606 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 361100004607 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 361100004608 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 361100004609 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 361100004610 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100004611 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 361100004612 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 361100004613 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 361100004614 DNA binding residues [nucleotide binding] 361100004615 drug binding residues [chemical binding]; other site 361100004616 dimer interface [polypeptide binding]; other site 361100004617 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 361100004618 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 361100004619 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 361100004620 Predicted membrane protein [Function unknown]; Region: COG2323 361100004621 Uncharacterized conserved protein [Function unknown]; Region: COG1434 361100004622 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 361100004623 putative active site [active] 361100004624 Tic20-like protein; Region: Tic20; pfam09685 361100004625 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 361100004626 dimer interface [polypeptide binding]; other site 361100004627 FMN binding site [chemical binding]; other site 361100004628 NADPH bind site [chemical binding]; other site 361100004629 DJ-1 family protein; Region: not_thiJ; TIGR01383 361100004630 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 361100004631 conserved cys residue [active] 361100004632 RNA polymerase factor sigma-70; Validated; Region: PRK06811 361100004633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100004634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100004635 DNA binding residues [nucleotide binding] 361100004636 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 361100004637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100004638 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100004639 putative substrate translocation pore; other site 361100004640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100004641 dimerization interface [polypeptide binding]; other site 361100004642 putative DNA binding site [nucleotide binding]; other site 361100004643 putative Zn2+ binding site [ion binding]; other site 361100004644 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100004645 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 361100004646 bacterial Hfq-like; Region: Hfq; cd01716 361100004647 hexamer interface [polypeptide binding]; other site 361100004648 Sm1 motif; other site 361100004649 RNA binding site [nucleotide binding]; other site 361100004650 Sm2 motif; other site 361100004651 HD domain; Region: HD_3; pfam13023 361100004652 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 361100004653 flagellar motor protein MotP; Reviewed; Region: PRK06743 361100004654 flagellar motor protein MotS; Reviewed; Region: PRK06742 361100004655 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 361100004656 ligand binding site [chemical binding]; other site 361100004657 Response regulator receiver domain; Region: Response_reg; pfam00072 361100004658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100004659 active site 361100004660 phosphorylation site [posttranslational modification] 361100004661 intermolecular recognition site; other site 361100004662 dimerization interface [polypeptide binding]; other site 361100004663 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 361100004664 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 361100004665 putative binding surface; other site 361100004666 active site 361100004667 P2 response regulator binding domain; Region: P2; pfam07194 361100004668 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 361100004669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100004670 ATP binding site [chemical binding]; other site 361100004671 Mg2+ binding site [ion binding]; other site 361100004672 G-X-G motif; other site 361100004673 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 361100004674 flagellar motor switch protein; Reviewed; Region: PRK06782 361100004675 CheC-like family; Region: CheC; pfam04509 361100004676 CheC-like family; Region: CheC; pfam04509 361100004677 CheC-like family; Region: CheC; pfam04509 361100004678 CheC-like family; Region: CheC; pfam04509 361100004679 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 361100004680 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 361100004681 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 361100004682 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 361100004683 Protein of unknown function (DUF327); Region: DUF327; pfam03885 361100004684 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 361100004685 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 361100004686 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 361100004687 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 361100004688 flagellar capping protein; Validated; Region: fliD; PRK06798 361100004689 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 361100004690 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 361100004691 Flagellar protein FliS; Region: FliS; cl00654 361100004692 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 361100004693 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 361100004694 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 361100004695 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 361100004696 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 361100004697 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 361100004698 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 361100004699 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 361100004700 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 361100004701 FliG C-terminal domain; Region: FliG_C; pfam01706 361100004702 flagellar assembly protein H; Validated; Region: fliH; PRK06800 361100004703 Flagellar assembly protein FliH; Region: FliH; pfam02108 361100004704 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 361100004705 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 361100004706 Walker A motif; other site 361100004707 ATP binding site [chemical binding]; other site 361100004708 Walker B motif; other site 361100004709 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 361100004710 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 361100004711 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 361100004712 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 361100004713 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 361100004714 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 361100004715 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 361100004716 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 361100004717 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 361100004718 Response regulator receiver domain; Region: Response_reg; pfam00072 361100004719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100004720 active site 361100004721 phosphorylation site [posttranslational modification] 361100004722 intermolecular recognition site; other site 361100004723 dimerization interface [polypeptide binding]; other site 361100004724 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 361100004725 flagellin; Provisional; Region: PRK12807 361100004726 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 361100004727 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 361100004728 flagellin; Provisional; Region: PRK12808 361100004729 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 361100004730 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 361100004731 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 361100004732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 361100004733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 361100004734 catalytic residue [active] 361100004735 flagellar motor switch protein; Validated; Region: PRK06789 361100004736 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 361100004737 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 361100004738 flagellar motor switch protein; Validated; Region: PRK06788 361100004739 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 361100004740 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 361100004741 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 361100004742 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 361100004743 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 361100004744 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 361100004745 FHIPEP family; Region: FHIPEP; pfam00771 361100004746 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 361100004747 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 361100004748 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 361100004749 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 361100004750 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 361100004751 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 361100004752 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 361100004753 C-terminal domain interface [polypeptide binding]; other site 361100004754 sugar binding site [chemical binding]; other site 361100004755 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 361100004756 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 361100004757 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 361100004758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100004759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100004760 Dienelactone hydrolase family; Region: DLH; pfam01738 361100004761 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 361100004762 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 361100004763 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 361100004764 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 361100004765 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 361100004766 Cna protein B-type domain; Region: Cna_B; pfam05738 361100004767 Cna protein B-type domain; Region: Cna_B; pfam05738 361100004768 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 361100004769 Cna protein B-type domain; Region: Cna_B; pfam05738 361100004770 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 361100004771 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 361100004772 active site 361100004773 catalytic site [active] 361100004774 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 361100004775 active site 361100004776 catalytic site [active] 361100004777 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 361100004778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100004779 non-specific DNA binding site [nucleotide binding]; other site 361100004780 salt bridge; other site 361100004781 sequence-specific DNA binding site [nucleotide binding]; other site 361100004782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100004783 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100004784 putative substrate translocation pore; other site 361100004785 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 361100004786 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100004787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100004788 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 361100004789 dimerization interface [polypeptide binding]; other site 361100004790 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 361100004791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100004792 Walker A/P-loop; other site 361100004793 ATP binding site [chemical binding]; other site 361100004794 Q-loop/lid; other site 361100004795 ABC transporter signature motif; other site 361100004796 Walker B; other site 361100004797 D-loop; other site 361100004798 H-loop/switch region; other site 361100004799 TOBE domain; Region: TOBE_2; pfam08402 361100004800 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 361100004801 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 361100004802 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 361100004803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100004804 dimer interface [polypeptide binding]; other site 361100004805 conserved gate region; other site 361100004806 putative PBP binding loops; other site 361100004807 ABC-ATPase subunit interface; other site 361100004808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100004809 dimer interface [polypeptide binding]; other site 361100004810 conserved gate region; other site 361100004811 putative PBP binding loops; other site 361100004812 ABC-ATPase subunit interface; other site 361100004813 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 361100004814 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 361100004815 Beta-Casp domain; Region: Beta-Casp; smart01027 361100004816 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 361100004817 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 361100004818 Cupin; Region: Cupin_1; smart00835 361100004819 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 361100004820 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 361100004821 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 361100004822 catalytic core [active] 361100004823 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100004824 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 361100004825 hypothetical protein; Provisional; Region: PRK09272 361100004826 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100004827 MarR family; Region: MarR_2; pfam12802 361100004828 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 361100004829 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 361100004830 active site 361100004831 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 361100004832 dimer interface [polypeptide binding]; other site 361100004833 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 361100004834 Ligand Binding Site [chemical binding]; other site 361100004835 Molecular Tunnel; other site 361100004836 RNA polymerase factor sigma-70; Validated; Region: PRK06811 361100004837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100004838 DNA binding residues [nucleotide binding] 361100004839 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 361100004840 VPS10 domain; Region: VPS10; smart00602 361100004841 VPS10 domain; Region: VPS10; smart00602 361100004842 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 361100004843 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 361100004844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100004845 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 361100004846 DNA-binding site [nucleotide binding]; DNA binding site 361100004847 FCD domain; Region: FCD; pfam07729 361100004848 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100004849 EamA-like transporter family; Region: EamA; pfam00892 361100004850 EamA-like transporter family; Region: EamA; pfam00892 361100004851 Methyltransferase domain; Region: Methyltransf_24; pfam13578 361100004852 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 361100004853 fumarate hydratase; Reviewed; Region: fumC; PRK00485 361100004854 Class II fumarases; Region: Fumarase_classII; cd01362 361100004855 active site 361100004856 tetramer interface [polypeptide binding]; other site 361100004857 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 361100004858 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 361100004859 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 361100004860 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 361100004861 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 361100004862 active site pocket [active] 361100004863 oxyanion hole [active] 361100004864 catalytic triad [active] 361100004865 active site nucleophile [active] 361100004866 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 361100004867 Penicillinase repressor; Region: Pencillinase_R; pfam03965 361100004868 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 361100004869 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 361100004870 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 361100004871 catalytic residues [active] 361100004872 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 361100004873 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 361100004874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100004875 non-specific DNA binding site [nucleotide binding]; other site 361100004876 salt bridge; other site 361100004877 sequence-specific DNA binding site [nucleotide binding]; other site 361100004878 Cupin domain; Region: Cupin_2; pfam07883 361100004879 D-serine dehydratase; Provisional; Region: PRK02991 361100004880 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 361100004881 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100004882 catalytic residue [active] 361100004883 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 361100004884 Protein of unknown function (DUF445); Region: DUF445; pfam04286 361100004885 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 361100004886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100004887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100004888 DNA binding residues [nucleotide binding] 361100004889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100004890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100004891 active site 361100004892 phosphorylation site [posttranslational modification] 361100004893 intermolecular recognition site; other site 361100004894 dimerization interface [polypeptide binding]; other site 361100004895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100004896 DNA binding residues [nucleotide binding] 361100004897 dimerization interface [polypeptide binding]; other site 361100004898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 361100004899 Histidine kinase; Region: HisKA_3; pfam07730 361100004900 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100004901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100004902 Walker A/P-loop; other site 361100004903 ATP binding site [chemical binding]; other site 361100004904 Q-loop/lid; other site 361100004905 ABC transporter signature motif; other site 361100004906 Walker B; other site 361100004907 D-loop; other site 361100004908 H-loop/switch region; other site 361100004909 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 361100004910 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 361100004911 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 361100004912 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 361100004913 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 361100004914 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 361100004915 PLD-like domain; Region: PLDc_2; pfam13091 361100004916 putative active site [active] 361100004917 catalytic site [active] 361100004918 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 361100004919 PLD-like domain; Region: PLDc_2; pfam13091 361100004920 putative active site [active] 361100004921 catalytic site [active] 361100004922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 361100004923 Histidine kinase; Region: HisKA_3; pfam07730 361100004924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100004925 ATP binding site [chemical binding]; other site 361100004926 Mg2+ binding site [ion binding]; other site 361100004927 G-X-G motif; other site 361100004928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100004929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100004930 active site 361100004931 phosphorylation site [posttranslational modification] 361100004932 intermolecular recognition site; other site 361100004933 dimerization interface [polypeptide binding]; other site 361100004934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100004935 DNA binding residues [nucleotide binding] 361100004936 dimerization interface [polypeptide binding]; other site 361100004937 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 361100004938 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 361100004939 putative sugar binding sites [chemical binding]; other site 361100004940 Q-X-W motif; other site 361100004941 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 361100004942 putative nucleotide binding site [chemical binding]; other site 361100004943 uridine monophosphate binding site [chemical binding]; other site 361100004944 homohexameric interface [polypeptide binding]; other site 361100004945 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 361100004946 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 361100004947 aspartate ammonia-lyase; Provisional; Region: PRK14515 361100004948 Aspartase; Region: Aspartase; cd01357 361100004949 active sites [active] 361100004950 tetramer interface [polypeptide binding]; other site 361100004951 malate dehydrogenase; Provisional; Region: PRK13529 361100004952 Malic enzyme, N-terminal domain; Region: malic; pfam00390 361100004953 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 361100004954 NAD(P) binding site [chemical binding]; other site 361100004955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100004956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100004957 ATP binding site [chemical binding]; other site 361100004958 Mg2+ binding site [ion binding]; other site 361100004959 G-X-G motif; other site 361100004960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100004961 Response regulator receiver domain; Region: Response_reg; pfam00072 361100004962 active site 361100004963 phosphorylation site [posttranslational modification] 361100004964 intermolecular recognition site; other site 361100004965 dimerization interface [polypeptide binding]; other site 361100004966 YcbB domain; Region: YcbB; pfam08664 361100004967 SWIM zinc finger; Region: SWIM; pfam04434 361100004968 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 361100004969 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 361100004970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100004971 ATP binding site [chemical binding]; other site 361100004972 putative Mg++ binding site [ion binding]; other site 361100004973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100004974 nucleotide binding region [chemical binding]; other site 361100004975 ATP-binding site [chemical binding]; other site 361100004976 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 361100004977 dimer interface [polypeptide binding]; other site 361100004978 active site 361100004979 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100004980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100004981 non-specific DNA binding site [nucleotide binding]; other site 361100004982 salt bridge; other site 361100004983 sequence-specific DNA binding site [nucleotide binding]; other site 361100004984 aspartate kinase; Reviewed; Region: PRK06635 361100004985 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 361100004986 putative nucleotide binding site [chemical binding]; other site 361100004987 putative catalytic residues [active] 361100004988 putative Mg ion binding site [ion binding]; other site 361100004989 putative aspartate binding site [chemical binding]; other site 361100004990 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 361100004991 putative allosteric regulatory site; other site 361100004992 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 361100004993 putative allosteric regulatory residue; other site 361100004994 DoxX-like family; Region: DoxX_3; pfam13781 361100004995 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 361100004996 YndJ-like protein; Region: YndJ; pfam14158 361100004997 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 361100004998 putative active site [active] 361100004999 nucleotide binding site [chemical binding]; other site 361100005000 nudix motif; other site 361100005001 putative metal binding site [ion binding]; other site 361100005002 S-layer homology domain; Region: SLH; pfam00395 361100005003 S-layer homology domain; Region: SLH; pfam00395 361100005004 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 361100005005 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 361100005006 active site 361100005007 metal binding site [ion binding]; metal-binding site 361100005008 S-layer homology domain; Region: SLH; pfam00395 361100005009 S-layer homology domain; Region: SLH; pfam00395 361100005010 S-layer homology domain; Region: SLH; pfam00395 361100005011 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 361100005012 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100005013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005014 putative substrate translocation pore; other site 361100005015 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 361100005016 Carbon starvation protein CstA; Region: CstA; pfam02554 361100005017 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 361100005018 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 361100005019 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100005020 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 361100005021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005022 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100005023 putative substrate translocation pore; other site 361100005024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005025 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100005026 putative substrate translocation pore; other site 361100005027 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 361100005028 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 361100005029 dimer interface [polypeptide binding]; other site 361100005030 active site 361100005031 CoA binding pocket [chemical binding]; other site 361100005032 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 361100005033 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 361100005034 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 361100005035 HflX GTPase family; Region: HflX; cd01878 361100005036 G1 box; other site 361100005037 GTP/Mg2+ binding site [chemical binding]; other site 361100005038 Switch I region; other site 361100005039 G2 box; other site 361100005040 G3 box; other site 361100005041 Switch II region; other site 361100005042 G4 box; other site 361100005043 G5 box; other site 361100005044 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100005045 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100005046 peptide binding site [polypeptide binding]; other site 361100005047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005048 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100005049 putative substrate translocation pore; other site 361100005050 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 361100005051 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 361100005052 dimer interface [polypeptide binding]; other site 361100005053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100005054 catalytic residue [active] 361100005055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005056 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100005057 Coenzyme A binding pocket [chemical binding]; other site 361100005058 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 361100005059 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 361100005060 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 361100005061 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 361100005062 Na2 binding site [ion binding]; other site 361100005063 putative substrate binding site 1 [chemical binding]; other site 361100005064 Na binding site 1 [ion binding]; other site 361100005065 putative substrate binding site 2 [chemical binding]; other site 361100005066 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 361100005067 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 361100005068 NodB motif; other site 361100005069 putative active site [active] 361100005070 putative catalytic site [active] 361100005071 putative Zn binding site [ion binding]; other site 361100005072 Mor transcription activator family; Region: Mor; cl02360 361100005073 Predicted membrane protein [Function unknown]; Region: COG2323 361100005074 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 361100005075 methionine sulfoxide reductase A; Provisional; Region: PRK14054 361100005076 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 361100005077 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 361100005078 homodimer interface [polypeptide binding]; other site 361100005079 substrate-cofactor binding pocket; other site 361100005080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100005081 catalytic residue [active] 361100005082 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 361100005083 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 361100005084 PYR/PP interface [polypeptide binding]; other site 361100005085 dimer interface [polypeptide binding]; other site 361100005086 TPP binding site [chemical binding]; other site 361100005087 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 361100005088 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 361100005089 TPP-binding site [chemical binding]; other site 361100005090 dimer interface [polypeptide binding]; other site 361100005091 acetolactate synthase 1 regulatory subunit; Validated; Region: PRK06737 361100005092 ketol-acid reductoisomerase; Provisional; Region: PRK05479 361100005093 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 361100005094 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 361100005095 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 361100005096 threonine dehydratase; Validated; Region: PRK08639 361100005097 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 361100005098 tetramer interface [polypeptide binding]; other site 361100005099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100005100 catalytic residue [active] 361100005101 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 361100005102 putative Ile/Val binding site [chemical binding]; other site 361100005103 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 361100005104 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 361100005105 putative active site [active] 361100005106 putative metal binding site [ion binding]; other site 361100005107 Protein of unknown function (DUF554); Region: DUF554; pfam04474 361100005108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005109 Coenzyme A binding pocket [chemical binding]; other site 361100005110 drug efflux system protein MdtG; Provisional; Region: PRK09874 361100005111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005112 putative substrate translocation pore; other site 361100005113 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 361100005114 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 361100005115 putative active site [active] 361100005116 metal binding site [ion binding]; metal-binding site 361100005117 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 361100005118 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 361100005119 LytTr DNA-binding domain; Region: LytTR; pfam04397 361100005120 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 361100005121 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 361100005122 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 361100005123 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 361100005124 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100005125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005126 Coenzyme A binding pocket [chemical binding]; other site 361100005127 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 361100005128 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 361100005129 active site 361100005130 putative substrate binding pocket [chemical binding]; other site 361100005131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100005132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100005133 ABC transporter signature motif; other site 361100005134 Walker B; other site 361100005135 D-loop; other site 361100005136 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100005137 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100005138 peptide binding site [polypeptide binding]; other site 361100005139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100005140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005141 Coenzyme A binding pocket [chemical binding]; other site 361100005142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100005143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100005144 active site 361100005145 phosphorylation site [posttranslational modification] 361100005146 intermolecular recognition site; other site 361100005147 dimerization interface [polypeptide binding]; other site 361100005148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100005149 DNA binding site [nucleotide binding] 361100005150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100005151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100005152 dimerization interface [polypeptide binding]; other site 361100005153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100005154 dimer interface [polypeptide binding]; other site 361100005155 phosphorylation site [posttranslational modification] 361100005156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100005157 ATP binding site [chemical binding]; other site 361100005158 Mg2+ binding site [ion binding]; other site 361100005159 G-X-G motif; other site 361100005160 Peptidase family M23; Region: Peptidase_M23; pfam01551 361100005161 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 361100005162 manganese transport protein MntH; Reviewed; Region: PRK00701 361100005163 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 361100005164 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 361100005165 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 361100005166 active site residue [active] 361100005167 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 361100005168 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 361100005169 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 361100005170 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 361100005171 Amino acid permease; Region: AA_permease_2; pfam13520 361100005172 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 361100005173 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 361100005174 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 361100005175 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 361100005176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100005177 DNA binding residues [nucleotide binding] 361100005178 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 361100005179 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 361100005180 intersubunit interface [polypeptide binding]; other site 361100005181 active site 361100005182 catalytic residue [active] 361100005183 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 361100005184 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 361100005185 Nucleoside recognition; Region: Gate; pfam07670 361100005186 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 361100005187 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 361100005188 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 361100005189 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 361100005190 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 361100005191 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 361100005192 active site 361100005193 catalytic motif [active] 361100005194 Zn binding site [ion binding]; other site 361100005195 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 361100005196 hypothetical protein; Provisional; Region: PRK01631 361100005197 proline aminopeptidase P II; Provisional; Region: PRK10879 361100005198 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 361100005199 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 361100005200 active site 361100005201 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 361100005202 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 361100005203 DNA topoisomerase III; Provisional; Region: PRK07726 361100005204 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 361100005205 active site 361100005206 putative interdomain interaction site [polypeptide binding]; other site 361100005207 putative metal-binding site [ion binding]; other site 361100005208 putative nucleotide binding site [chemical binding]; other site 361100005209 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 361100005210 domain I; other site 361100005211 DNA binding groove [nucleotide binding] 361100005212 phosphate binding site [ion binding]; other site 361100005213 domain II; other site 361100005214 domain III; other site 361100005215 nucleotide binding site [chemical binding]; other site 361100005216 catalytic site [active] 361100005217 domain IV; other site 361100005218 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 361100005219 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 361100005220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005221 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100005222 putative substrate translocation pore; other site 361100005223 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 361100005224 Sodium Bile acid symporter family; Region: SBF; cl17470 361100005225 azoreductase; Provisional; Region: PRK13555 361100005226 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 361100005227 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100005228 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 361100005229 dimer interface [polypeptide binding]; other site 361100005230 substrate binding site [chemical binding]; other site 361100005231 metal binding site [ion binding]; metal-binding site 361100005232 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 361100005233 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 361100005234 YtkA-like; Region: YtkA; pfam13115 361100005235 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 361100005236 Domain of unkown function (DUF1775); Region: DUF1775; pfam07987 361100005237 EamA-like transporter family; Region: EamA; pfam00892 361100005238 EamA-like transporter family; Region: EamA; pfam00892 361100005239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100005240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100005241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 361100005242 dimerization interface [polypeptide binding]; other site 361100005243 Predicted transcriptional regulator [Transcription]; Region: COG1959 361100005244 Transcriptional regulator; Region: Rrf2; pfam02082 361100005245 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 361100005246 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 361100005247 catalytic residues [active] 361100005248 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 361100005249 dimer interface [polypeptide binding]; other site 361100005250 FMN binding site [chemical binding]; other site 361100005251 amidase; Provisional; Region: PRK06707 361100005252 Amidase; Region: Amidase; cl11426 361100005253 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 361100005254 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 361100005255 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 361100005256 dimer interface [polypeptide binding]; other site 361100005257 tetramer (dimer of dimers) interface [polypeptide binding]; other site 361100005258 NAD binding site [chemical binding]; other site 361100005259 substrate binding site [chemical binding]; other site 361100005260 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 361100005261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 361100005262 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 361100005263 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 361100005264 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 361100005265 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 361100005266 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 361100005267 putative ligand binding site [chemical binding]; other site 361100005268 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 361100005269 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 361100005270 Walker A/P-loop; other site 361100005271 ATP binding site [chemical binding]; other site 361100005272 Q-loop/lid; other site 361100005273 ABC transporter signature motif; other site 361100005274 Walker B; other site 361100005275 D-loop; other site 361100005276 H-loop/switch region; other site 361100005277 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 361100005278 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 361100005279 Walker A/P-loop; other site 361100005280 ATP binding site [chemical binding]; other site 361100005281 Q-loop/lid; other site 361100005282 ABC transporter signature motif; other site 361100005283 Walker B; other site 361100005284 D-loop; other site 361100005285 H-loop/switch region; other site 361100005286 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 361100005287 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 361100005288 TM-ABC transporter signature motif; other site 361100005289 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 361100005290 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 361100005291 TM-ABC transporter signature motif; other site 361100005292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100005293 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 361100005294 LysR substrate binding domain; Region: LysR_substrate; pfam03466 361100005295 dimerization interface [polypeptide binding]; other site 361100005296 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 361100005297 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100005298 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100005299 putative Zn2+ binding site [ion binding]; other site 361100005300 putative DNA binding site [nucleotide binding]; other site 361100005301 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 361100005302 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 361100005303 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 361100005304 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 361100005305 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 361100005306 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 361100005307 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 361100005308 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100005309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100005310 Walker A/P-loop; other site 361100005311 ATP binding site [chemical binding]; other site 361100005312 Q-loop/lid; other site 361100005313 ABC transporter signature motif; other site 361100005314 Walker B; other site 361100005315 D-loop; other site 361100005316 H-loop/switch region; other site 361100005317 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 361100005318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100005319 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 361100005320 Walker A/P-loop; other site 361100005321 ATP binding site [chemical binding]; other site 361100005322 Q-loop/lid; other site 361100005323 ABC transporter signature motif; other site 361100005324 Walker B; other site 361100005325 D-loop; other site 361100005326 H-loop/switch region; other site 361100005327 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 361100005328 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 361100005329 active site 361100005330 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 361100005331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 361100005332 active site 361100005333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100005334 Methyltransferase domain; Region: Methyltransf_23; pfam13489 361100005335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 361100005336 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 361100005337 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 361100005338 inhibitor-cofactor binding pocket; inhibition site 361100005339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100005340 catalytic residue [active] 361100005341 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 361100005342 trimer interface [polypeptide binding]; other site 361100005343 active site 361100005344 substrate binding site [chemical binding]; other site 361100005345 CoA binding site [chemical binding]; other site 361100005346 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 361100005347 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 361100005348 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100005349 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 361100005350 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 361100005351 dimer interface [polypeptide binding]; other site 361100005352 FMN binding site [chemical binding]; other site 361100005353 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100005354 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100005355 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100005356 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 361100005357 NlpC/P60 family; Region: NLPC_P60; pfam00877 361100005358 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100005359 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 361100005360 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100005361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100005362 Walker A/P-loop; other site 361100005363 ATP binding site [chemical binding]; other site 361100005364 Q-loop/lid; other site 361100005365 ABC transporter signature motif; other site 361100005366 Walker B; other site 361100005367 D-loop; other site 361100005368 H-loop/switch region; other site 361100005369 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100005370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100005371 active site 361100005372 phosphorylation site [posttranslational modification] 361100005373 intermolecular recognition site; other site 361100005374 dimerization interface [polypeptide binding]; other site 361100005375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100005376 DNA binding site [nucleotide binding] 361100005377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100005378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100005379 dimerization interface [polypeptide binding]; other site 361100005380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100005381 dimer interface [polypeptide binding]; other site 361100005382 phosphorylation site [posttranslational modification] 361100005383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100005384 ATP binding site [chemical binding]; other site 361100005385 Mg2+ binding site [ion binding]; other site 361100005386 G-X-G motif; other site 361100005387 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 361100005388 classical (c) SDRs; Region: SDR_c; cd05233 361100005389 NAD(P) binding site [chemical binding]; other site 361100005390 active site 361100005391 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 361100005392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100005393 S-adenosylmethionine binding site [chemical binding]; other site 361100005394 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 361100005395 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 361100005396 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 361100005397 NodB motif; other site 361100005398 active site 361100005399 catalytic site [active] 361100005400 metal binding site [ion binding]; metal-binding site 361100005401 SdpI/YhfL protein family; Region: SdpI; pfam13630 361100005402 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 361100005403 nudix motif; other site 361100005404 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 361100005405 homoserine dehydrogenase; Provisional; Region: PRK06349 361100005406 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 361100005407 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 361100005408 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 361100005409 threonine synthase; Reviewed; Region: PRK06721 361100005410 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 361100005411 homodimer interface [polypeptide binding]; other site 361100005412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100005413 catalytic residue [active] 361100005414 homoserine kinase; Provisional; Region: PRK01212 361100005415 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 361100005416 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 361100005417 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 361100005418 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 361100005419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100005420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100005421 ATP binding site [chemical binding]; other site 361100005422 G-X-G motif; other site 361100005423 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 361100005424 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 361100005425 NodB motif; other site 361100005426 active site 361100005427 catalytic site [active] 361100005428 Zn binding site [ion binding]; other site 361100005429 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 361100005430 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 361100005431 MgtC family; Region: MgtC; pfam02308 361100005432 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100005433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005434 Coenzyme A binding pocket [chemical binding]; other site 361100005435 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 361100005436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100005438 putative substrate translocation pore; other site 361100005439 Lysine efflux permease [General function prediction only]; Region: COG1279 361100005440 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 361100005441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100005442 DNA-binding site [nucleotide binding]; DNA binding site 361100005443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100005444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100005445 homodimer interface [polypeptide binding]; other site 361100005446 catalytic residue [active] 361100005447 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 361100005448 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 361100005449 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 361100005450 active site 361100005451 nucleophile elbow; other site 361100005452 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 361100005453 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 361100005454 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 361100005455 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 361100005456 nudix motif; other site 361100005457 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 361100005458 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 361100005459 homodimer interface [polypeptide binding]; other site 361100005460 NAD binding pocket [chemical binding]; other site 361100005461 ATP binding pocket [chemical binding]; other site 361100005462 Mg binding site [ion binding]; other site 361100005463 active-site loop [active] 361100005464 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100005465 FtsX-like permease family; Region: FtsX; pfam02687 361100005466 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 361100005467 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 361100005468 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 361100005469 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 361100005470 active site 361100005471 catalytic residues [active] 361100005472 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 361100005473 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 361100005474 Walker A/P-loop; other site 361100005475 ATP binding site [chemical binding]; other site 361100005476 Q-loop/lid; other site 361100005477 ABC transporter signature motif; other site 361100005478 Walker B; other site 361100005479 D-loop; other site 361100005480 H-loop/switch region; other site 361100005481 TOBE domain; Region: TOBE_2; pfam08402 361100005482 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 361100005483 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 361100005484 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 361100005485 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 361100005486 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 361100005487 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 361100005488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100005489 dimer interface [polypeptide binding]; other site 361100005490 conserved gate region; other site 361100005491 putative PBP binding loops; other site 361100005492 ABC-ATPase subunit interface; other site 361100005493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 361100005494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100005495 dimer interface [polypeptide binding]; other site 361100005496 conserved gate region; other site 361100005497 putative PBP binding loops; other site 361100005498 ABC-ATPase subunit interface; other site 361100005499 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 361100005500 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 361100005501 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 361100005502 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 361100005503 nucleotide binding site [chemical binding]; other site 361100005504 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 361100005505 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 361100005506 dimer interface [polypeptide binding]; other site 361100005507 active site 361100005508 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 361100005509 putative active site [active] 361100005510 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 361100005511 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 361100005512 active site 361100005513 dimer interface [polypeptide binding]; other site 361100005514 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 361100005515 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 361100005516 putative substrate binding site [chemical binding]; other site 361100005517 putative ATP binding site [chemical binding]; other site 361100005518 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 361100005519 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 361100005520 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 361100005521 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 361100005522 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 361100005523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100005524 dimerization interface [polypeptide binding]; other site 361100005525 putative DNA binding site [nucleotide binding]; other site 361100005526 putative Zn2+ binding site [ion binding]; other site 361100005527 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 361100005528 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 361100005529 active site 361100005530 catalytic tetrad [active] 361100005531 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 361100005532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005533 putative substrate translocation pore; other site 361100005534 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 361100005535 DinB superfamily; Region: DinB_2; pfam12867 361100005536 Protein of unknown function (DUF664); Region: DUF664; pfam04978 361100005537 GTPase RsgA; Reviewed; Region: PRK01889 361100005538 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 361100005539 RNA binding site [nucleotide binding]; other site 361100005540 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 361100005541 GTPase/Zn-binding domain interface [polypeptide binding]; other site 361100005542 GTP/Mg2+ binding site [chemical binding]; other site 361100005543 G4 box; other site 361100005544 G5 box; other site 361100005545 G1 box; other site 361100005546 Switch I region; other site 361100005547 G2 box; other site 361100005548 G3 box; other site 361100005549 Switch II region; other site 361100005550 Tar ligand binding domain homologue; Region: TarH; pfam02203 361100005551 Cache domain; Region: Cache_1; pfam02743 361100005552 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 361100005553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100005554 dimerization interface [polypeptide binding]; other site 361100005555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100005556 dimer interface [polypeptide binding]; other site 361100005557 putative CheW interface [polypeptide binding]; other site 361100005558 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 361100005559 Uncharacterized membrane protein [Function unknown]; Region: COG3949 361100005560 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 361100005561 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 361100005562 dimerization interface [polypeptide binding]; other site 361100005563 DPS ferroxidase diiron center [ion binding]; other site 361100005564 ion pore; other site 361100005565 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 361100005566 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 361100005567 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 361100005568 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 361100005569 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 361100005570 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 361100005571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 361100005572 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100005573 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100005574 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 361100005575 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 361100005576 active site 361100005577 catalytic tetrad [active] 361100005578 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 361100005579 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 361100005580 P-loop, Walker A motif; other site 361100005581 Base recognition motif; other site 361100005582 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 361100005583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100005584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005585 Coenzyme A binding pocket [chemical binding]; other site 361100005586 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 361100005587 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 361100005588 metal binding site [ion binding]; metal-binding site 361100005589 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 361100005590 NADH(P)-binding; Region: NAD_binding_10; pfam13460 361100005591 NAD binding site [chemical binding]; other site 361100005592 active site 361100005593 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 361100005594 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 361100005595 active site 361100005596 FMN binding site [chemical binding]; other site 361100005597 substrate binding site [chemical binding]; other site 361100005598 homotetramer interface [polypeptide binding]; other site 361100005599 catalytic residue [active] 361100005600 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 361100005601 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 361100005602 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 361100005603 DNA binding site [nucleotide binding] 361100005604 active site 361100005605 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 361100005606 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100005607 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100005608 peptide binding site [polypeptide binding]; other site 361100005609 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 361100005610 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 361100005611 active site 361100005612 metal binding site [ion binding]; metal-binding site 361100005613 short chain dehydrogenase; Provisional; Region: PRK08309 361100005614 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 361100005615 catalytic core [active] 361100005616 CotH protein; Region: CotH; pfam08757 361100005617 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 361100005618 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 361100005619 nudix motif; other site 361100005620 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 361100005621 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 361100005622 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 361100005623 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 361100005624 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 361100005625 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 361100005626 Cl binding site [ion binding]; other site 361100005627 oligomer interface [polypeptide binding]; other site 361100005628 Predicted permeases [General function prediction only]; Region: COG0701 361100005629 Predicted membrane protein [Function unknown]; Region: COG3689 361100005630 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 361100005631 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 361100005632 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 361100005633 putative active site [active] 361100005634 catalytic site [active] 361100005635 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 361100005636 putative active site [active] 361100005637 catalytic site [active] 361100005638 Coat F domain; Region: Coat_F; pfam07875 361100005639 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 361100005640 NADH(P)-binding; Region: NAD_binding_10; pfam13460 361100005641 NAD binding site [chemical binding]; other site 361100005642 substrate binding site [chemical binding]; other site 361100005643 putative active site [active] 361100005644 Protein of unknown function (DUF456); Region: DUF456; pfam04306 361100005645 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 361100005646 Domain of unknown function DUF21; Region: DUF21; pfam01595 361100005647 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 361100005648 Transporter associated domain; Region: CorC_HlyC; smart01091 361100005649 FOG: CBS domain [General function prediction only]; Region: COG0517 361100005650 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 361100005651 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 361100005652 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 361100005653 dimer interface [polypeptide binding]; other site 361100005654 putative tRNA-binding site [nucleotide binding]; other site 361100005655 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 361100005656 DinB superfamily; Region: DinB_2; pfam12867 361100005657 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 361100005658 stage II sporulation protein P; Region: spore_II_P; TIGR02867 361100005659 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100005660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005661 Coenzyme A binding pocket [chemical binding]; other site 361100005662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100005663 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 361100005664 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 361100005665 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 361100005666 nudix motif; other site 361100005667 amidase; Provisional; Region: PRK06828 361100005668 Amidase; Region: Amidase; pfam01425 361100005669 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100005670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005671 putative substrate translocation pore; other site 361100005672 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 361100005673 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 361100005674 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 361100005675 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 361100005676 catalytic core [active] 361100005677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100005678 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 361100005679 active site 361100005680 motif I; other site 361100005681 motif II; other site 361100005682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100005683 DinB superfamily; Region: DinB_2; pfam12867 361100005684 DinB family; Region: DinB; cl17821 361100005685 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 361100005686 alanine racemase; Reviewed; Region: alr; PRK00053 361100005687 active site 361100005688 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 361100005689 dimer interface [polypeptide binding]; other site 361100005690 substrate binding site [chemical binding]; other site 361100005691 catalytic residues [active] 361100005692 Methyltransferase domain; Region: Methyltransf_31; pfam13847 361100005693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100005694 S-adenosylmethionine binding site [chemical binding]; other site 361100005695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005696 Coenzyme A binding pocket [chemical binding]; other site 361100005697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005698 Coenzyme A binding pocket [chemical binding]; other site 361100005699 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 361100005700 glycosyltransferase, MGT family; Region: MGT; TIGR01426 361100005701 active site 361100005702 TDP-binding site; other site 361100005703 acceptor substrate-binding pocket; other site 361100005704 homodimer interface [polypeptide binding]; other site 361100005705 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100005706 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100005707 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100005708 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 361100005709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100005710 DNA-binding site [nucleotide binding]; DNA binding site 361100005711 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100005712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100005713 homodimer interface [polypeptide binding]; other site 361100005714 catalytic residue [active] 361100005715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005716 Coenzyme A binding pocket [chemical binding]; other site 361100005717 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100005718 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 361100005719 active site 361100005720 metal binding site [ion binding]; metal-binding site 361100005721 Src Homology 3 domain superfamily; Region: SH3; cl17036 361100005722 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 361100005723 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100005724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005725 Coenzyme A binding pocket [chemical binding]; other site 361100005726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100005727 potential frameshift: common BLAST hit: gi|52143339|ref|YP_083488.1| group-specific protein 361100005728 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 361100005729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100005730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005731 Coenzyme A binding pocket [chemical binding]; other site 361100005732 Cupin domain; Region: Cupin_2; cl17218 361100005733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005734 Coenzyme A binding pocket [chemical binding]; other site 361100005735 Predicted acetyltransferase [General function prediction only]; Region: COG3393 361100005736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005737 Coenzyme A binding pocket [chemical binding]; other site 361100005738 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 361100005739 Methyltransferase domain; Region: Methyltransf_23; pfam13489 361100005740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100005741 S-adenosylmethionine binding site [chemical binding]; other site 361100005742 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 361100005743 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 361100005744 Potassium binding sites [ion binding]; other site 361100005745 Cesium cation binding sites [ion binding]; other site 361100005746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 361100005747 DEAD-like helicases superfamily; Region: DEXDc; smart00487 361100005748 ATP binding site [chemical binding]; other site 361100005749 putative Mg++ binding site [ion binding]; other site 361100005750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100005751 nucleotide binding region [chemical binding]; other site 361100005752 ATP-binding site [chemical binding]; other site 361100005753 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 361100005754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100005755 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 361100005756 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 361100005757 NADP binding site [chemical binding]; other site 361100005758 dimer interface [polypeptide binding]; other site 361100005759 RNA polymerase sigma factor; Provisional; Region: PRK12543 361100005760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100005761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100005762 DNA binding residues [nucleotide binding] 361100005763 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 361100005764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100005765 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 361100005766 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 361100005767 catalytic residues [active] 361100005768 dimer interface [polypeptide binding]; other site 361100005769 Sulfate transporter family; Region: Sulfate_transp; pfam00916 361100005770 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 361100005771 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 361100005772 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 361100005773 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 361100005774 Protein of unknown function DUF58; Region: DUF58; pfam01882 361100005775 MoxR-like ATPases [General function prediction only]; Region: COG0714 361100005776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100005777 Walker A motif; other site 361100005778 ATP binding site [chemical binding]; other site 361100005779 Walker B motif; other site 361100005780 arginine finger; other site 361100005781 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 361100005782 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 361100005783 [4Fe-4S] binding site [ion binding]; other site 361100005784 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 361100005785 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 361100005786 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 361100005787 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 361100005788 molybdopterin cofactor binding site; other site 361100005789 nitrate reductase, beta subunit; Region: narH; TIGR01660 361100005790 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 361100005791 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 361100005792 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 361100005793 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 361100005794 ligand binding site [chemical binding]; other site 361100005795 flexible hinge region; other site 361100005796 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 361100005797 putative switch regulator; other site 361100005798 non-specific DNA interactions [nucleotide binding]; other site 361100005799 DNA binding site [nucleotide binding] 361100005800 sequence specific DNA binding site [nucleotide binding]; other site 361100005801 putative cAMP binding site [chemical binding]; other site 361100005802 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 361100005803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100005804 FeS/SAM binding site; other site 361100005805 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 361100005806 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 361100005807 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 361100005808 ATP binding site [chemical binding]; other site 361100005809 substrate interface [chemical binding]; other site 361100005810 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 361100005811 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 361100005812 dimer interface [polypeptide binding]; other site 361100005813 putative functional site; other site 361100005814 putative MPT binding site; other site 361100005815 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 361100005816 MoaE homodimer interface [polypeptide binding]; other site 361100005817 MoaD interaction [polypeptide binding]; other site 361100005818 active site residues [active] 361100005819 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 361100005820 MoaE interaction surface [polypeptide binding]; other site 361100005821 MoeB interaction surface [polypeptide binding]; other site 361100005822 thiocarboxylated glycine; other site 361100005823 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 361100005824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100005825 putative substrate translocation pore; other site 361100005826 PspC domain; Region: PspC; pfam04024 361100005827 Predicted permeases [General function prediction only]; Region: COG0679 361100005828 precorrin-2 dehydrogenase; Validated; Region: PRK06719 361100005829 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 361100005830 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 361100005831 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 361100005832 putative active site [active] 361100005833 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 361100005834 putative active site [active] 361100005835 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 361100005836 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 361100005837 active site 361100005838 SAM binding site [chemical binding]; other site 361100005839 homodimer interface [polypeptide binding]; other site 361100005840 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 361100005841 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 361100005842 [2Fe-2S] cluster binding site [ion binding]; other site 361100005843 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 361100005844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 361100005845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100005846 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 361100005847 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 361100005848 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 361100005849 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 361100005850 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 361100005851 Hemerythrin-like domain; Region: Hr-like; cd12108 361100005852 Excalibur calcium-binding domain; Region: Excalibur; smart00894 361100005853 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 361100005854 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 361100005855 PGAP1-like protein; Region: PGAP1; pfam07819 361100005856 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 361100005857 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 361100005858 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 361100005859 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100005860 Zn2+ binding site [ion binding]; other site 361100005861 Mg2+ binding site [ion binding]; other site 361100005862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 361100005863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100005864 Walker A/P-loop; other site 361100005865 ATP binding site [chemical binding]; other site 361100005866 ABC transporter; Region: ABC_tran; pfam00005 361100005867 Q-loop/lid; other site 361100005868 ABC transporter signature motif; other site 361100005869 Walker B; other site 361100005870 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 361100005871 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 361100005872 putative active site [active] 361100005873 putative NTP binding site [chemical binding]; other site 361100005874 putative nucleic acid binding site [nucleotide binding]; other site 361100005875 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 361100005876 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 361100005877 Type II intron maturase; Region: Intron_maturas2; pfam01348 361100005878 ABC transporter; Region: ABC_tran_2; pfam12848 361100005879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100005880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100005881 Bax inhibitor 1 like; Region: BaxI_1; cl17691 361100005882 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 361100005883 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 361100005884 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 361100005885 dimer interface [polypeptide binding]; other site 361100005886 ssDNA binding site [nucleotide binding]; other site 361100005887 tetramer (dimer of dimers) interface [polypeptide binding]; other site 361100005888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100005889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100005890 hypothetical protein; Provisional; Region: PRK06753 361100005891 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 361100005892 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 361100005893 Virulence factor; Region: Virulence_fact; pfam13769 361100005894 HEAT repeats; Region: HEAT_2; pfam13646 361100005895 HEAT repeats; Region: HEAT_2; pfam13646 361100005896 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 361100005897 Protein of unknown function, DUF393; Region: DUF393; pfam04134 361100005898 Disulphide isomerase; Region: Disulph_isomer; pfam06491 361100005899 Brix domain; Region: Brix; cl00935 361100005900 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 361100005901 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 361100005902 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 361100005903 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 361100005904 active site 361100005905 HIGH motif; other site 361100005906 KMSK motif region; other site 361100005907 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 361100005908 tRNA binding surface [nucleotide binding]; other site 361100005909 anticodon binding site; other site 361100005910 Methyltransferase domain; Region: Methyltransf_12; pfam08242 361100005911 Methyltransferase domain; Region: Methyltransf_31; pfam13847 361100005912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100005913 binding surface 361100005914 TPR motif; other site 361100005915 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 361100005916 putative active site [active] 361100005917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100005918 binding surface 361100005919 TPR motif; other site 361100005920 TPR repeat; Region: TPR_11; pfam13414 361100005921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100005922 binding surface 361100005923 TPR motif; other site 361100005924 Tetratricopeptide repeat; Region: TPR_16; pfam13432 361100005925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100005926 binding surface 361100005927 TPR motif; other site 361100005928 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 361100005929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100005930 TPR motif; other site 361100005931 binding surface 361100005932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100005933 binding surface 361100005934 TPR motif; other site 361100005935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100005936 binding surface 361100005937 TPR motif; other site 361100005938 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 361100005939 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 361100005940 HIGH motif; other site 361100005941 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 361100005942 active site 361100005943 KMSKS motif; other site 361100005944 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 361100005945 tRNA binding surface [nucleotide binding]; other site 361100005946 anticodon binding site; other site 361100005947 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 361100005948 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 361100005949 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 361100005950 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 361100005951 Zn binding site [ion binding]; other site 361100005952 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 361100005953 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 361100005954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 361100005955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 361100005956 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 361100005957 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 361100005958 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 361100005959 homodimer interface [polypeptide binding]; other site 361100005960 motif 1; other site 361100005961 motif 2; other site 361100005962 active site 361100005963 motif 3; other site 361100005964 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 361100005965 Na2 binding site [ion binding]; other site 361100005966 putative substrate binding site 1 [chemical binding]; other site 361100005967 Na binding site 1 [ion binding]; other site 361100005968 putative substrate binding site 2 [chemical binding]; other site 361100005969 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100005970 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 361100005971 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 361100005972 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 361100005973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100005974 motif II; other site 361100005975 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 361100005976 fructuronate transporter; Provisional; Region: PRK10034; cl15264 361100005977 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 361100005978 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 361100005979 active site 361100005980 NAD binding site [chemical binding]; other site 361100005981 metal binding site [ion binding]; metal-binding site 361100005982 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 361100005983 aspartate racemase; Region: asp_race; TIGR00035 361100005984 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 361100005985 homodimer interaction site [polypeptide binding]; other site 361100005986 cofactor binding site; other site 361100005987 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100005988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005989 Coenzyme A binding pocket [chemical binding]; other site 361100005990 hypothetical protein; Validated; Region: PRK06769 361100005991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100005992 active site 361100005993 motif I; other site 361100005994 motif II; other site 361100005995 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 361100005996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100005997 Coenzyme A binding pocket [chemical binding]; other site 361100005998 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 361100005999 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100006000 Walker A/P-loop; other site 361100006001 ATP binding site [chemical binding]; other site 361100006002 Q-loop/lid; other site 361100006003 ABC transporter signature motif; other site 361100006004 Walker B; other site 361100006005 D-loop; other site 361100006006 H-loop/switch region; other site 361100006007 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 361100006008 YpjP-like protein; Region: YpjP; pfam14005 361100006009 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 361100006010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100006011 motif II; other site 361100006012 hypothetical protein; Provisional; Region: PRK06724 361100006013 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100006014 active site 361100006015 metal binding site [ion binding]; metal-binding site 361100006016 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 361100006017 Phosphotransferase enzyme family; Region: APH; pfam01636 361100006018 substrate binding site [chemical binding]; other site 361100006019 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100006020 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100006021 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 361100006022 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 361100006023 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 361100006024 thymidylate synthase; Region: thym_sym; TIGR03284 361100006025 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 361100006026 dimerization interface [polypeptide binding]; other site 361100006027 active site 361100006028 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 361100006029 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 361100006030 folate binding site [chemical binding]; other site 361100006031 NADP+ binding site [chemical binding]; other site 361100006032 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 361100006033 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100006034 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 361100006035 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100006036 azoreductase; Reviewed; Region: PRK00170 361100006037 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 361100006038 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 361100006039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 361100006040 putative acyl-acceptor binding pocket; other site 361100006041 Haemolysin-III related; Region: HlyIII; cl03831 361100006042 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 361100006043 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 361100006044 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 361100006045 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 361100006046 EDD domain protein, DegV family; Region: DegV; TIGR00762 361100006047 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 361100006048 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 361100006049 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 361100006050 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 361100006051 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 361100006052 Cu(I) binding site [ion binding]; other site 361100006053 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 361100006054 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 361100006055 putative dimer interface [polypeptide binding]; other site 361100006056 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 361100006057 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 361100006058 active site 361100006059 dimer interface [polypeptide binding]; other site 361100006060 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 361100006061 Ligand Binding Site [chemical binding]; other site 361100006062 Molecular Tunnel; other site 361100006063 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100006064 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 361100006065 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 361100006066 siderophore binding site; other site 361100006067 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 361100006068 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 361100006069 homodimer interface [polypeptide binding]; other site 361100006070 substrate-cofactor binding pocket; other site 361100006071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100006072 catalytic residue [active] 361100006073 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 361100006074 FMN binding site [chemical binding]; other site 361100006075 dimer interface [polypeptide binding]; other site 361100006076 Isochorismatase family; Region: Isochorismatase; pfam00857 361100006077 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 361100006078 catalytic triad [active] 361100006079 conserved cis-peptide bond; other site 361100006080 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 361100006081 nudix motif; other site 361100006082 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 361100006083 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 361100006084 putative dimer interface [polypeptide binding]; other site 361100006085 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 361100006086 Mechanosensitive ion channel; Region: MS_channel; pfam00924 361100006087 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 361100006088 GAF domain; Region: GAF; pfam01590 361100006089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 361100006090 Histidine kinase; Region: HisKA_3; pfam07730 361100006091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100006092 ATP binding site [chemical binding]; other site 361100006093 Mg2+ binding site [ion binding]; other site 361100006094 G-X-G motif; other site 361100006095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100006096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100006097 active site 361100006098 phosphorylation site [posttranslational modification] 361100006099 intermolecular recognition site; other site 361100006100 dimerization interface [polypeptide binding]; other site 361100006101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100006102 DNA binding residues [nucleotide binding] 361100006103 dimerization interface [polypeptide binding]; other site 361100006104 potential frameshift: common BLAST hit: gi|218897233|ref|YP_002445644.1| transcriptional regulator, RpiR family 361100006105 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 361100006106 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 361100006107 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 361100006108 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 361100006109 putative active site [active] 361100006110 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 361100006111 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 361100006112 NAD binding site [chemical binding]; other site 361100006113 substrate binding site [chemical binding]; other site 361100006114 catalytic Zn binding site [ion binding]; other site 361100006115 tetramer interface [polypeptide binding]; other site 361100006116 structural Zn binding site [ion binding]; other site 361100006117 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 361100006118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100006119 dimer interface [polypeptide binding]; other site 361100006120 conserved gate region; other site 361100006121 ABC-ATPase subunit interface; other site 361100006122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100006123 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 361100006124 dimer interface [polypeptide binding]; other site 361100006125 conserved gate region; other site 361100006126 putative PBP binding loops; other site 361100006127 ABC-ATPase subunit interface; other site 361100006128 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100006129 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100006130 Erythromycin esterase; Region: Erythro_esteras; pfam05139 361100006131 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 361100006132 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 361100006133 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 361100006134 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 361100006135 active site 361100006136 Predicted flavoprotein [General function prediction only]; Region: COG0431 361100006137 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 361100006138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006139 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100006140 putative substrate translocation pore; other site 361100006141 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 361100006142 Uncharacterized conserved protein [Function unknown]; Region: COG1434 361100006143 putative active site [active] 361100006144 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 361100006145 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 361100006146 Walker A/P-loop; other site 361100006147 ATP binding site [chemical binding]; other site 361100006148 Q-loop/lid; other site 361100006149 ABC transporter signature motif; other site 361100006150 Walker B; other site 361100006151 D-loop; other site 361100006152 H-loop/switch region; other site 361100006153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100006154 dimer interface [polypeptide binding]; other site 361100006155 conserved gate region; other site 361100006156 ABC-ATPase subunit interface; other site 361100006157 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 361100006158 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 361100006159 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 361100006160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 361100006161 Protein of unknown function (DUF524); Region: DUF524; pfam04411 361100006162 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 361100006163 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 361100006164 DNA binding residues [nucleotide binding] 361100006165 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 361100006166 Domain of unknown function DUF21; Region: DUF21; pfam01595 361100006167 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 361100006168 Transporter associated domain; Region: CorC_HlyC; smart01091 361100006169 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 361100006170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100006171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100006172 ATP binding site [chemical binding]; other site 361100006173 Mg2+ binding site [ion binding]; other site 361100006174 G-X-G motif; other site 361100006175 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 361100006176 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 361100006177 hypothetical protein; Provisional; Region: PRK06917 361100006178 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 361100006179 inhibitor-cofactor binding pocket; inhibition site 361100006180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100006181 catalytic residue [active] 361100006182 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 361100006183 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 361100006184 acetylornithine deacetylase; Validated; Region: PRK06915 361100006185 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 361100006186 metal binding site [ion binding]; metal-binding site 361100006187 dimer interface [polypeptide binding]; other site 361100006188 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 361100006189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100006190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 361100006191 PAS fold; Region: PAS_4; pfam08448 361100006192 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 361100006193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100006194 Walker A motif; other site 361100006195 ATP binding site [chemical binding]; other site 361100006196 Walker B motif; other site 361100006197 arginine finger; other site 361100006198 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 361100006199 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 361100006200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100006201 FeS/SAM binding site; other site 361100006202 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 361100006203 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 361100006204 toxin interface [polypeptide binding]; other site 361100006205 Zn binding site [ion binding]; other site 361100006206 hypothetical protein; Provisional; Region: PRK13672 361100006207 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 361100006208 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 361100006209 YozD-like protein; Region: YozD; pfam14162 361100006210 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 361100006211 Catalytic domain of Protein Kinases; Region: PKc; cd00180 361100006212 active site 361100006213 ATP binding site [chemical binding]; other site 361100006214 substrate binding site [chemical binding]; other site 361100006215 activation loop (A-loop); other site 361100006216 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 361100006217 SpoOM protein; Region: Spo0M; pfam07070 361100006218 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 361100006219 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 361100006220 active site 361100006221 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 361100006222 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 361100006223 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 361100006224 catalytic residues [active] 361100006225 Terminase small subunit; Region: Terminase_2; cl01513 361100006226 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 361100006227 CHRD domain; Region: CHRD; pfam07452 361100006228 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 361100006229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100006230 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 361100006231 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 361100006232 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 361100006233 C1q domain; Region: C1q; cl17543 361100006234 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 361100006235 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 361100006236 YolD-like protein; Region: YolD; pfam08863 361100006237 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 361100006238 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 361100006239 Transglycosylase; Region: Transgly; pfam00912 361100006240 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 361100006241 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100006242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100006244 putative substrate translocation pore; other site 361100006245 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 361100006246 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 361100006247 dimer interface [polypeptide binding]; other site 361100006248 Citrate synthase; Region: Citrate_synt; pfam00285 361100006249 active site 361100006250 coenzyme A binding site [chemical binding]; other site 361100006251 citrylCoA binding site [chemical binding]; other site 361100006252 oxalacetate/citrate binding site [chemical binding]; other site 361100006253 catalytic triad [active] 361100006254 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 361100006255 2-methylcitrate dehydratase; Region: prpD; TIGR02330 361100006256 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 361100006257 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 361100006258 tetramer interface [polypeptide binding]; other site 361100006259 active site 361100006260 Mg2+/Mn2+ binding site [ion binding]; other site 361100006261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 361100006262 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 361100006263 active site 361100006264 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 361100006265 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 361100006266 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 361100006267 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 361100006268 tetrameric interface [polypeptide binding]; other site 361100006269 NAD binding site [chemical binding]; other site 361100006270 catalytic residues [active] 361100006271 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 361100006272 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 361100006273 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 361100006274 substrate binding site [chemical binding]; other site 361100006275 oxyanion hole (OAH) forming residues; other site 361100006276 trimer interface [polypeptide binding]; other site 361100006277 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 361100006278 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 361100006279 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 361100006280 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 361100006281 active site 361100006282 metal binding site [ion binding]; metal-binding site 361100006283 DNA binding site [nucleotide binding] 361100006284 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 361100006285 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 361100006286 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 361100006287 Walker A/P-loop; other site 361100006288 ATP binding site [chemical binding]; other site 361100006289 Q-loop/lid; other site 361100006290 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 361100006291 ABC transporter signature motif; other site 361100006292 Walker B; other site 361100006293 D-loop; other site 361100006294 H-loop/switch region; other site 361100006295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100006296 dimerization interface [polypeptide binding]; other site 361100006297 putative DNA binding site [nucleotide binding]; other site 361100006298 putative Zn2+ binding site [ion binding]; other site 361100006299 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 361100006300 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 361100006301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006302 putative substrate translocation pore; other site 361100006303 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 361100006304 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 361100006305 putative NAD(P) binding site [chemical binding]; other site 361100006306 active site 361100006307 isochorismate synthase DhbC; Validated; Region: PRK06923 361100006308 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 361100006309 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 361100006310 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 361100006311 acyl-activating enzyme (AAE) consensus motif; other site 361100006312 active site 361100006313 AMP binding site [chemical binding]; other site 361100006314 substrate binding site [chemical binding]; other site 361100006315 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 361100006316 hydrophobic substrate binding pocket; other site 361100006317 Isochorismatase family; Region: Isochorismatase; pfam00857 361100006318 active site 361100006319 conserved cis-peptide bond; other site 361100006320 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 361100006321 Condensation domain; Region: Condensation; pfam00668 361100006322 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 361100006323 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 361100006324 acyl-activating enzyme (AAE) consensus motif; other site 361100006325 AMP binding site [chemical binding]; other site 361100006326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 361100006327 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 361100006328 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 361100006329 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 361100006330 acyl-activating enzyme (AAE) consensus motif; other site 361100006331 AMP binding site [chemical binding]; other site 361100006332 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 361100006333 MbtH-like protein; Region: MbtH; cl01279 361100006334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006335 putative transporter; Provisional; Region: PRK10504 361100006336 putative substrate translocation pore; other site 361100006337 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 361100006338 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 361100006339 Chorismate lyase; Region: Chor_lyase; cl01230 361100006340 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 361100006341 IHF dimer interface [polypeptide binding]; other site 361100006342 IHF - DNA interface [nucleotide binding]; other site 361100006343 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 361100006344 DinB family; Region: DinB; cl17821 361100006345 DinB superfamily; Region: DinB_2; pfam12867 361100006346 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 361100006347 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 361100006348 active site 361100006349 catalytic triad [active] 361100006350 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 361100006351 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 361100006352 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 361100006353 metal binding triad [ion binding]; metal-binding site 361100006354 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 361100006355 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 361100006356 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100006357 RNA binding surface [nucleotide binding]; other site 361100006358 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 361100006359 probable active site [active] 361100006360 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 361100006361 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 361100006362 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 361100006363 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 361100006364 active site 361100006365 dimer interface [polypeptide binding]; other site 361100006366 motif 1; other site 361100006367 motif 2; other site 361100006368 motif 3; other site 361100006369 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 361100006370 anticodon binding site; other site 361100006371 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100006372 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100006373 Walker A/P-loop; other site 361100006374 ATP binding site [chemical binding]; other site 361100006375 Q-loop/lid; other site 361100006376 ABC transporter signature motif; other site 361100006377 Walker B; other site 361100006378 D-loop; other site 361100006379 H-loop/switch region; other site 361100006380 FtsX-like permease family; Region: FtsX; pfam02687 361100006381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006382 Transposase IS200 like; Region: Y1_Tnp; pfam01797 361100006383 Probable transposase; Region: OrfB_IS605; pfam01385 361100006384 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 361100006385 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 361100006386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 361100006387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 361100006388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100006389 dimer interface [polypeptide binding]; other site 361100006390 conserved gate region; other site 361100006391 ABC-ATPase subunit interface; other site 361100006392 pyruvate oxidase; Provisional; Region: PRK08611 361100006393 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 361100006394 PYR/PP interface [polypeptide binding]; other site 361100006395 dimer interface [polypeptide binding]; other site 361100006396 tetramer interface [polypeptide binding]; other site 361100006397 TPP binding site [chemical binding]; other site 361100006398 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 361100006399 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 361100006400 TPP-binding site [chemical binding]; other site 361100006401 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 361100006402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100006403 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 361100006404 active site 361100006405 dimerization interface [polypeptide binding]; other site 361100006406 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 361100006407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 361100006408 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100006409 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100006410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100006411 MMPL family; Region: MMPL; pfam03176 361100006412 MMPL family; Region: MMPL; pfam03176 361100006413 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 361100006414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006415 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 361100006416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100006417 Coenzyme A binding pocket [chemical binding]; other site 361100006418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100006419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100006421 Coenzyme A binding pocket [chemical binding]; other site 361100006422 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 361100006423 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 361100006424 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 361100006425 putative acetyltransferase YhhY; Provisional; Region: PRK10140 361100006426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006427 Coenzyme A binding pocket [chemical binding]; other site 361100006428 EamA-like transporter family; Region: EamA; pfam00892 361100006429 EamA-like transporter family; Region: EamA; pfam00892 361100006430 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 361100006431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100006432 non-specific DNA binding site [nucleotide binding]; other site 361100006433 salt bridge; other site 361100006434 sequence-specific DNA binding site [nucleotide binding]; other site 361100006435 Cupin domain; Region: Cupin_2; pfam07883 361100006436 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 361100006437 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100006438 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 361100006439 protoporphyrinogen oxidase; Provisional; Region: PRK12416 361100006440 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 361100006441 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 361100006442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100006443 S-adenosylmethionine binding site [chemical binding]; other site 361100006444 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100006445 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100006446 Cold-inducible protein YdjO; Region: YdjO; pfam14169 361100006447 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 361100006448 DNA-binding site [nucleotide binding]; DNA binding site 361100006449 RNA-binding motif; other site 361100006450 CAAX protease self-immunity; Region: Abi; pfam02517 361100006451 AAA domain; Region: AAA_17; pfam13207 361100006452 AAA domain; Region: AAA_18; pfam13238 361100006453 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 361100006454 active site 361100006455 metal binding site [ion binding]; metal-binding site 361100006456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100006457 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 361100006458 active site 361100006459 motif I; other site 361100006460 motif II; other site 361100006461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100006462 hypothetical protein; Provisional; Region: PRK06770 361100006463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100006464 MarR family; Region: MarR_2; cl17246 361100006465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006466 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 361100006467 putative substrate translocation pore; other site 361100006468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100006469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100006470 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 361100006471 dimerization interface [polypeptide binding]; other site 361100006472 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 361100006473 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 361100006474 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 361100006475 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 361100006476 active site 361100006477 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 361100006478 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 361100006479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100006480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 361100006481 dimerization interface [polypeptide binding]; other site 361100006482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 361100006483 MOSC domain; Region: MOSC; pfam03473 361100006484 3-alpha domain; Region: 3-alpha; pfam03475 361100006485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006486 Coenzyme A binding pocket [chemical binding]; other site 361100006487 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 361100006488 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 361100006489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100006490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100006491 Walker A/P-loop; other site 361100006492 ATP binding site [chemical binding]; other site 361100006493 Q-loop/lid; other site 361100006494 ABC transporter signature motif; other site 361100006495 Walker B; other site 361100006496 D-loop; other site 361100006497 H-loop/switch region; other site 361100006498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 361100006499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100006500 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 361100006501 Walker A/P-loop; other site 361100006502 ATP binding site [chemical binding]; other site 361100006503 Q-loop/lid; other site 361100006504 ABC transporter signature motif; other site 361100006505 Walker B; other site 361100006506 D-loop; other site 361100006507 H-loop/switch region; other site 361100006508 LysE type translocator; Region: LysE; cl00565 361100006509 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 361100006510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100006511 non-specific DNA binding site [nucleotide binding]; other site 361100006512 salt bridge; other site 361100006513 sequence-specific DNA binding site [nucleotide binding]; other site 361100006514 Cupin domain; Region: Cupin_2; pfam07883 361100006515 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 361100006516 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 361100006517 BclB C-terminal domain; Region: exospore_TM; TIGR03721 361100006518 Cupin; Region: Cupin_1; smart00835 361100006519 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 361100006520 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 361100006521 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 361100006522 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 361100006523 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100006524 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 361100006525 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 361100006526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100006527 S-adenosylmethionine binding site [chemical binding]; other site 361100006528 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 361100006529 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 361100006530 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 361100006531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 361100006532 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 361100006533 active site 361100006534 P-loop; other site 361100006535 phosphorylation site [posttranslational modification] 361100006536 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 361100006537 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 361100006538 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 361100006539 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 361100006540 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 361100006541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 361100006542 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 361100006543 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100006544 catalytic residue [active] 361100006545 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 361100006546 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 361100006547 tetramer interface [polypeptide binding]; other site 361100006548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100006549 catalytic residue [active] 361100006550 Uncharacterized conserved protein [Function unknown]; Region: COG3339 361100006551 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100006552 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 361100006553 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 361100006554 ATP binding site [chemical binding]; other site 361100006555 Mg++ binding site [ion binding]; other site 361100006556 motif III; other site 361100006557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100006558 nucleotide binding region [chemical binding]; other site 361100006559 ATP-binding site [chemical binding]; other site 361100006560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100006561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100006562 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100006563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 361100006564 FtsX-like permease family; Region: FtsX; pfam02687 361100006565 FtsX-like permease family; Region: FtsX; pfam02687 361100006566 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100006567 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100006568 Walker A/P-loop; other site 361100006569 ATP binding site [chemical binding]; other site 361100006570 Q-loop/lid; other site 361100006571 ABC transporter signature motif; other site 361100006572 Walker B; other site 361100006573 D-loop; other site 361100006574 H-loop/switch region; other site 361100006575 Methyltransferase domain; Region: Methyltransf_23; pfam13489 361100006576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100006577 S-adenosylmethionine binding site [chemical binding]; other site 361100006578 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 361100006579 dimer interface [polypeptide binding]; other site 361100006580 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 361100006581 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 361100006582 dimer interface [polypeptide binding]; other site 361100006583 PYR/PP interface [polypeptide binding]; other site 361100006584 TPP binding site [chemical binding]; other site 361100006585 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 361100006586 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 361100006587 TPP-binding site [chemical binding]; other site 361100006588 dimer interface [polypeptide binding]; other site 361100006589 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100006590 MarR family; Region: MarR_2; pfam12802 361100006591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 361100006592 catalytic core [active] 361100006593 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 361100006594 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 361100006595 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 361100006596 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 361100006597 metal binding site [ion binding]; metal-binding site 361100006598 dimer interface [polypeptide binding]; other site 361100006599 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 361100006600 active site 361100006601 catalytic triad [active] 361100006602 oxyanion hole [active] 361100006603 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 361100006604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100006605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100006606 DNA binding residues [nucleotide binding] 361100006607 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 361100006608 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100006609 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100006610 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 361100006611 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100006612 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100006613 beta-lactamase TEM; Provisional; Region: PRK15442 361100006614 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 361100006615 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 361100006616 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100006617 putative active site [active] 361100006618 putative metal binding site [ion binding]; other site 361100006619 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100006620 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 361100006621 Walker A/P-loop; other site 361100006622 ATP binding site [chemical binding]; other site 361100006623 Q-loop/lid; other site 361100006624 ABC transporter signature motif; other site 361100006625 Walker B; other site 361100006626 D-loop; other site 361100006627 H-loop/switch region; other site 361100006628 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 361100006629 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 361100006630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100006631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100006632 Protein of unknown function (DUF523); Region: DUF523; pfam04463 361100006633 Uncharacterized conserved protein [Function unknown]; Region: COG3272 361100006634 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 361100006635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 361100006636 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 361100006637 FAD binding site [chemical binding]; other site 361100006638 homotetramer interface [polypeptide binding]; other site 361100006639 substrate binding pocket [chemical binding]; other site 361100006640 catalytic base [active] 361100006641 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 361100006642 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 361100006643 ATP-grasp domain; Region: ATP-grasp_4; cl17255 361100006644 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 361100006645 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 361100006646 carboxyltransferase (CT) interaction site; other site 361100006647 biotinylation site [posttranslational modification]; other site 361100006648 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 361100006649 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 361100006650 active site 361100006651 catalytic residues [active] 361100006652 metal binding site [ion binding]; metal-binding site 361100006653 enoyl-CoA hydratase; Provisional; Region: PRK07657 361100006654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 361100006655 substrate binding site [chemical binding]; other site 361100006656 oxyanion hole (OAH) forming residues; other site 361100006657 trimer interface [polypeptide binding]; other site 361100006658 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 361100006659 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 361100006660 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 361100006661 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 361100006662 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 361100006663 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 361100006664 acyl-activating enzyme (AAE) consensus motif; other site 361100006665 putative AMP binding site [chemical binding]; other site 361100006666 putative active site [active] 361100006667 putative CoA binding site [chemical binding]; other site 361100006668 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100006669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006670 Coenzyme A binding pocket [chemical binding]; other site 361100006671 hypothetical protein; Provisional; Region: PRK08233 361100006672 DinB family; Region: DinB; cl17821 361100006673 DinB superfamily; Region: DinB_2; pfam12867 361100006674 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 361100006675 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100006676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100006677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100006678 dimer interface [polypeptide binding]; other site 361100006679 phosphorylation site [posttranslational modification] 361100006680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100006681 ATP binding site [chemical binding]; other site 361100006682 Mg2+ binding site [ion binding]; other site 361100006683 G-X-G motif; other site 361100006684 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100006685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100006686 active site 361100006687 phosphorylation site [posttranslational modification] 361100006688 intermolecular recognition site; other site 361100006689 dimerization interface [polypeptide binding]; other site 361100006690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100006691 DNA binding site [nucleotide binding] 361100006692 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100006693 Zn2+ binding site [ion binding]; other site 361100006694 Mg2+ binding site [ion binding]; other site 361100006695 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 361100006696 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 361100006697 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 361100006698 NADH(P)-binding; Region: NAD_binding_10; pfam13460 361100006699 NAD binding site [chemical binding]; other site 361100006700 substrate binding site [chemical binding]; other site 361100006701 putative active site [active] 361100006702 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100006703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006704 Coenzyme A binding pocket [chemical binding]; other site 361100006705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006706 Coenzyme A binding pocket [chemical binding]; other site 361100006707 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 361100006708 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 361100006709 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 361100006710 active site 361100006711 Zn binding site [ion binding]; other site 361100006712 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 361100006713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 361100006714 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 361100006715 putative hydrophobic ligand binding site [chemical binding]; other site 361100006716 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100006717 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 361100006718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 361100006719 Integrase core domain; Region: rve; pfam00665 361100006720 transposase/IS protein; Provisional; Region: PRK09183 361100006721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100006722 Walker A motif; other site 361100006723 ATP binding site [chemical binding]; other site 361100006724 Walker B motif; other site 361100006725 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100006726 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100006727 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 361100006728 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100006729 DNA binding residues [nucleotide binding] 361100006730 drug binding residues [chemical binding]; other site 361100006731 dimer interface [polypeptide binding]; other site 361100006732 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 361100006733 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100006734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006735 putative substrate translocation pore; other site 361100006736 potential frameshift: common BLAST hit: gi|217960028|ref|YP_002338584.1| serine/threonine protein kinase 361100006737 Methyltransferase domain; Region: Methyltransf_31; pfam13847 361100006738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100006739 S-adenosylmethionine binding site [chemical binding]; other site 361100006740 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 361100006741 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 361100006742 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 361100006743 active site 361100006744 ATP binding site [chemical binding]; other site 361100006745 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 361100006746 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 361100006747 active site 361100006748 Zn binding site [ion binding]; other site 361100006749 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 361100006750 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 361100006751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100006752 DNA-binding site [nucleotide binding]; DNA binding site 361100006753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100006754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100006755 homodimer interface [polypeptide binding]; other site 361100006756 catalytic residue [active] 361100006757 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 361100006758 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 361100006759 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 361100006760 putative NAD(P) binding site [chemical binding]; other site 361100006761 Predicted membrane protein [Function unknown]; Region: COG2323 361100006762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100006763 S-adenosylmethionine binding site [chemical binding]; other site 361100006764 Methyltransferase domain; Region: Methyltransf_31; pfam13847 361100006765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100006766 S-adenosylmethionine binding site [chemical binding]; other site 361100006767 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 361100006768 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 361100006769 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 361100006770 active site 361100006771 HIGH motif; other site 361100006772 KMSKS motif; other site 361100006773 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 361100006774 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 361100006775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100006776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100006777 active site 361100006778 phosphorylation site [posttranslational modification] 361100006779 intermolecular recognition site; other site 361100006780 dimerization interface [polypeptide binding]; other site 361100006781 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100006782 DNA binding site [nucleotide binding] 361100006783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100006784 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 361100006785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100006786 ATP binding site [chemical binding]; other site 361100006787 Mg2+ binding site [ion binding]; other site 361100006788 G-X-G motif; other site 361100006789 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 361100006790 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100006791 ABC transporter; Region: ABC_tran_2; pfam12848 361100006792 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100006793 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100006794 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100006795 Walker A/P-loop; other site 361100006796 ATP binding site [chemical binding]; other site 361100006797 Q-loop/lid; other site 361100006798 ABC transporter signature motif; other site 361100006799 Walker B; other site 361100006800 D-loop; other site 361100006801 H-loop/switch region; other site 361100006802 FtsX-like permease family; Region: FtsX; pfam02687 361100006803 hypothetical protein; Provisional; Region: PRK06760 361100006804 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 361100006805 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 361100006806 homoserine dehydrogenase; Validated; Region: PRK06813 361100006807 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 361100006808 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 361100006809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100006810 DNA-binding site [nucleotide binding]; DNA binding site 361100006811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100006812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100006813 homodimer interface [polypeptide binding]; other site 361100006814 catalytic residue [active] 361100006815 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 361100006816 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 361100006817 ATP-grasp domain; Region: ATP-grasp_4; cl17255 361100006818 Putative transcription activator [Transcription]; Region: TenA; COG0819 361100006819 Helix-turn-helix domain; Region: HTH_38; pfam13936 361100006820 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 361100006821 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 361100006822 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 361100006823 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 361100006824 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 361100006825 Protein of unknown function; Region: DUF3658; pfam12395 361100006826 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 361100006827 Cytochrome P450; Region: p450; cl12078 361100006828 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100006829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006830 putative substrate translocation pore; other site 361100006831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006832 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 361100006833 trimer interface [polypeptide binding]; other site 361100006834 active site 361100006835 substrate binding site [chemical binding]; other site 361100006836 CoA binding site [chemical binding]; other site 361100006837 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 361100006838 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100006839 Transcriptional regulator PadR-like family; Region: PadR; cl17335 361100006840 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 361100006841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100006842 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 361100006843 active site 361100006844 motif I; other site 361100006845 motif II; other site 361100006846 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 361100006847 PAS domain S-box; Region: sensory_box; TIGR00229 361100006848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100006849 putative active site [active] 361100006850 heme pocket [chemical binding]; other site 361100006851 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 361100006852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100006853 dimer interface [polypeptide binding]; other site 361100006854 phosphorylation site [posttranslational modification] 361100006855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100006856 ATP binding site [chemical binding]; other site 361100006857 Mg2+ binding site [ion binding]; other site 361100006858 G-X-G motif; other site 361100006859 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 361100006860 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100006861 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100006862 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100006863 glycosyltransferase, MGT family; Region: MGT; TIGR01426 361100006864 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 361100006865 aspartate racemase; Region: asp_race; TIGR00035 361100006866 hypothetical protein; Provisional; Region: PRK13661 361100006867 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 361100006868 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 361100006869 Walker A/P-loop; other site 361100006870 ATP binding site [chemical binding]; other site 361100006871 Q-loop/lid; other site 361100006872 ABC transporter signature motif; other site 361100006873 Walker B; other site 361100006874 D-loop; other site 361100006875 H-loop/switch region; other site 361100006876 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 361100006877 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 361100006878 Walker A/P-loop; other site 361100006879 ATP binding site [chemical binding]; other site 361100006880 Q-loop/lid; other site 361100006881 ABC transporter signature motif; other site 361100006882 Walker B; other site 361100006883 D-loop; other site 361100006884 H-loop/switch region; other site 361100006885 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 361100006886 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 361100006887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100006888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100006889 dimer interface [polypeptide binding]; other site 361100006890 phosphorylation site [posttranslational modification] 361100006891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100006892 ATP binding site [chemical binding]; other site 361100006893 Mg2+ binding site [ion binding]; other site 361100006894 G-X-G motif; other site 361100006895 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 361100006896 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 361100006897 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 361100006898 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 361100006899 NAD(P) binding site [chemical binding]; other site 361100006900 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 361100006901 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 361100006902 active site 361100006903 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 361100006904 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100006905 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100006906 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 361100006907 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 361100006908 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 361100006909 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 361100006910 classical (c) SDRs; Region: SDR_c; cd05233 361100006911 NAD(P) binding site [chemical binding]; other site 361100006912 active site 361100006913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006914 putative substrate translocation pore; other site 361100006915 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100006916 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100006917 putative acetyltransferase; Provisional; Region: PRK03624 361100006918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006919 Coenzyme A binding pocket [chemical binding]; other site 361100006920 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 361100006921 EDD domain protein, DegV family; Region: DegV; TIGR00762 361100006922 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 361100006923 Putative amidotransferase; Region: DUF4066; pfam13278 361100006924 conserved cys residue [active] 361100006925 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 361100006926 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100006927 DNA binding residues [nucleotide binding] 361100006928 putative dimer interface [polypeptide binding]; other site 361100006929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100006930 S-adenosylmethionine binding site [chemical binding]; other site 361100006931 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100006932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006934 Coenzyme A binding pocket [chemical binding]; other site 361100006935 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 361100006936 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 361100006937 active site 361100006938 catalytic site [active] 361100006939 metal binding site [ion binding]; metal-binding site 361100006940 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 361100006941 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 361100006942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100006943 DNA-binding site [nucleotide binding]; DNA binding site 361100006944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100006945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100006946 homodimer interface [polypeptide binding]; other site 361100006947 catalytic residue [active] 361100006948 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100006949 EamA-like transporter family; Region: EamA; pfam00892 361100006950 EamA-like transporter family; Region: EamA; pfam00892 361100006951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006952 Coenzyme A binding pocket [chemical binding]; other site 361100006953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 361100006954 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 361100006955 nudix motif; other site 361100006956 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 361100006957 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100006958 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100006959 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 361100006960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100006961 putative substrate translocation pore; other site 361100006962 Cadmium resistance transporter; Region: Cad; pfam03596 361100006963 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 361100006964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100006965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100006966 Coenzyme A binding pocket [chemical binding]; other site 361100006967 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 361100006968 nudix motif; other site 361100006969 DNA polymerase III subunit beta; Validated; Region: PRK06673 361100006970 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 361100006971 putative DNA binding surface [nucleotide binding]; other site 361100006972 dimer interface [polypeptide binding]; other site 361100006973 beta-clamp/clamp loader binding surface; other site 361100006974 beta-clamp/translesion DNA polymerase binding surface; other site 361100006975 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 361100006976 putative active site [active] 361100006977 nucleotide binding site [chemical binding]; other site 361100006978 nudix motif; other site 361100006979 putative metal binding site [ion binding]; other site 361100006980 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100006981 DNA-directed RNA polymerase subunit A''; Provisional; Region: PRK14898 361100006982 translation initiation factor IF-2; Provisional; Region: PRK14845 361100006983 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 361100006984 homotrimer interaction site [polypeptide binding]; other site 361100006985 putative active site [active] 361100006986 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 361100006987 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 361100006988 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 361100006989 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cd02688 361100006990 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 361100006991 YxiJ-like protein; Region: YxiJ; pfam14176 361100006992 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 361100006993 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 361100006994 active site 361100006995 nucleophile elbow; other site 361100006996 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 361100006997 pentamer interface [polypeptide binding]; other site 361100006998 dodecaamer interface [polypeptide binding]; other site 361100006999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007000 Coenzyme A binding pocket [chemical binding]; other site 361100007001 metal-dependent hydrolase; Provisional; Region: PRK13291 361100007002 DinB superfamily; Region: DinB_2; pfam12867 361100007003 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100007004 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100007005 hypothetical protein; Provisional; Region: PRK06185 361100007006 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 361100007007 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 361100007008 GIY-YIG motif/motif A; other site 361100007009 active site 361100007010 catalytic site [active] 361100007011 putative DNA binding site [nucleotide binding]; other site 361100007012 metal binding site [ion binding]; metal-binding site 361100007013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007014 Coenzyme A binding pocket [chemical binding]; other site 361100007015 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 361100007016 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 361100007017 active site 361100007018 ATP binding site [chemical binding]; other site 361100007019 substrate binding site [chemical binding]; other site 361100007020 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 361100007021 nudix motif; other site 361100007022 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 361100007023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 361100007024 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 361100007025 N-acetyltransferase; Region: Acetyltransf_2; cl00949 361100007026 MepB protein; Region: MepB; pfam08877 361100007027 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 361100007028 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 361100007029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100007030 motif II; other site 361100007031 DinB superfamily; Region: DinB_2; pfam12867 361100007032 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 361100007033 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 361100007034 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 361100007035 active site 361100007036 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 361100007037 carbohydrate binding site [chemical binding]; other site 361100007038 pullulanase, type I; Region: pulA_typeI; TIGR02104 361100007039 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 361100007040 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 361100007041 Ca binding site [ion binding]; other site 361100007042 active site 361100007043 catalytic site [active] 361100007044 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 361100007045 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 361100007046 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 361100007047 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 361100007048 active site 361100007049 Zn binding site [ion binding]; other site 361100007050 Putative zinc-finger; Region: zf-HC2; pfam13490 361100007051 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 361100007052 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 361100007053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100007054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100007055 DNA binding residues [nucleotide binding] 361100007056 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 361100007057 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 361100007058 SecY translocase; Region: SecY; pfam00344 361100007059 hypothetical protein; Validated; Region: PRK06672 361100007060 DnaA N-terminal domain; Region: DnaA_N; pfam11638 361100007061 DnaA N-terminal domain; Region: DnaA_N; pfam11638 361100007062 DnaA N-terminal domain; Region: DnaA_N; pfam11638 361100007063 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100007064 TAP-like protein; Region: Abhydrolase_4; pfam08386 361100007065 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 361100007066 Mg binding site [ion binding]; other site 361100007067 nucleotide binding site [chemical binding]; other site 361100007068 putative protofilament interface [polypeptide binding]; other site 361100007069 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 361100007070 Predicted membrane protein [Function unknown]; Region: COG4129 361100007071 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 361100007072 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100007073 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 361100007074 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 361100007075 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 361100007076 germination protein YpeB; Region: spore_YpeB; TIGR02889 361100007077 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 361100007078 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 361100007079 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 361100007080 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 361100007081 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100007082 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100007083 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 361100007084 arylformamidase; Region: trp_arylform; TIGR03035 361100007085 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 361100007086 kynureninase; Region: kynureninase; TIGR01814 361100007087 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100007088 catalytic residue [active] 361100007089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100007090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100007091 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 361100007092 nudix motif; other site 361100007093 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 361100007094 hydrophobic ligand binding site; other site 361100007095 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 361100007096 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 361100007097 GAF domain; Region: GAF; pfam01590 361100007098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100007099 Walker A motif; other site 361100007100 ATP binding site [chemical binding]; other site 361100007101 Walker B motif; other site 361100007102 arginine finger; other site 361100007103 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 361100007104 NIPSNAP; Region: NIPSNAP; pfam07978 361100007105 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 361100007106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007107 Coenzyme A binding pocket [chemical binding]; other site 361100007108 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 361100007109 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 361100007110 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 361100007111 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 361100007112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 361100007113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100007114 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 361100007115 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 361100007116 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 361100007117 E3 interaction surface; other site 361100007118 lipoyl attachment site [posttranslational modification]; other site 361100007119 e3 binding domain; Region: E3_binding; pfam02817 361100007120 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 361100007121 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 361100007122 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 361100007123 alpha subunit interface [polypeptide binding]; other site 361100007124 TPP binding site [chemical binding]; other site 361100007125 heterodimer interface [polypeptide binding]; other site 361100007126 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 361100007127 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 361100007128 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 361100007129 tetramer interface [polypeptide binding]; other site 361100007130 TPP-binding site [chemical binding]; other site 361100007131 heterodimer interface [polypeptide binding]; other site 361100007132 phosphorylation loop region [posttranslational modification] 361100007133 DinB superfamily; Region: DinB_2; pfam12867 361100007134 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 361100007135 short chain dehydrogenase; Provisional; Region: PRK06914 361100007136 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 361100007137 NADP binding site [chemical binding]; other site 361100007138 active site 361100007139 steroid binding site; other site 361100007140 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 361100007141 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 361100007142 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 361100007143 nudix motif; other site 361100007144 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 361100007145 Protein phosphatase 2C; Region: PP2C_2; pfam13672 361100007146 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 361100007147 nucleotide binding site/active site [active] 361100007148 HIT family signature motif; other site 361100007149 catalytic residue [active] 361100007150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100007151 dimer interface [polypeptide binding]; other site 361100007152 conserved gate region; other site 361100007153 putative PBP binding loops; other site 361100007154 ABC-ATPase subunit interface; other site 361100007155 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 361100007156 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 361100007157 Walker A/P-loop; other site 361100007158 ATP binding site [chemical binding]; other site 361100007159 Q-loop/lid; other site 361100007160 ABC transporter signature motif; other site 361100007161 Walker B; other site 361100007162 D-loop; other site 361100007163 H-loop/switch region; other site 361100007164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 361100007165 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 361100007166 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 361100007167 Clp protease; Region: CLP_protease; pfam00574 361100007168 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 361100007169 oligomer interface [polypeptide binding]; other site 361100007170 active site residues [active] 361100007171 RNA polymerase factor sigma-70; Validated; Region: PRK06704 361100007172 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100007173 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 361100007174 DNA binding residues [nucleotide binding] 361100007175 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 361100007176 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 361100007177 catalytic loop [active] 361100007178 iron binding site [ion binding]; other site 361100007179 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 361100007180 tetramer (dimer of dimers) interface [polypeptide binding]; other site 361100007181 active site 361100007182 dimer interface [polypeptide binding]; other site 361100007183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007184 Coenzyme A binding pocket [chemical binding]; other site 361100007185 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 361100007186 glycosyltransferase, MGT family; Region: MGT; TIGR01426 361100007187 active site 361100007188 TDP-binding site; other site 361100007189 acceptor substrate-binding pocket; other site 361100007190 homodimer interface [polypeptide binding]; other site 361100007191 Uncharacterized conserved protein [Function unknown]; Region: COG1262 361100007192 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 361100007193 topology modulation protein; Reviewed; Region: PRK08118 361100007194 AAA domain; Region: AAA_17; pfam13207 361100007195 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 361100007196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100007197 S-adenosylmethionine binding site [chemical binding]; other site 361100007198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 361100007199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007200 Coenzyme A binding pocket [chemical binding]; other site 361100007201 S-layer homology domain; Region: SLH; pfam00395 361100007202 S-layer homology domain; Region: SLH; pfam00395 361100007203 S-layer homology domain; Region: SLH; pfam00395 361100007204 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 361100007205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100007206 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 361100007207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007208 Coenzyme A binding pocket [chemical binding]; other site 361100007209 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 361100007210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007211 Coenzyme A binding pocket [chemical binding]; other site 361100007212 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100007213 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 361100007214 Protein of unknown function (DUF952); Region: DUF952; pfam06108 361100007215 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 361100007216 Part of AAA domain; Region: AAA_19; pfam13245 361100007217 Family description; Region: UvrD_C_2; pfam13538 361100007218 CAAX protease self-immunity; Region: Abi; pfam02517 361100007219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100007220 S-adenosylmethionine binding site [chemical binding]; other site 361100007221 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 361100007222 putative active site pocket [active] 361100007223 dimerization interface [polypeptide binding]; other site 361100007224 putative catalytic residue [active] 361100007225 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 361100007226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100007227 ATP binding site [chemical binding]; other site 361100007228 putative Mg++ binding site [ion binding]; other site 361100007229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100007230 nucleotide binding region [chemical binding]; other site 361100007231 ATP-binding site [chemical binding]; other site 361100007232 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 361100007233 HRDC domain; Region: HRDC; pfam00570 361100007234 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 361100007235 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 361100007236 active site 361100007237 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 361100007238 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 361100007239 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 361100007240 active site 361100007241 metal binding site [ion binding]; metal-binding site 361100007242 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 361100007243 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 361100007244 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 361100007245 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 361100007246 active site 361100007247 Zn binding site [ion binding]; other site 361100007248 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 361100007249 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 361100007250 DHHA2 domain; Region: DHHA2; pfam02833 361100007251 Chitin binding domain; Region: Chitin_bind_3; pfam03067 361100007252 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100007253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007254 Coenzyme A binding pocket [chemical binding]; other site 361100007255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100007256 Zn2+ binding site [ion binding]; other site 361100007257 Mg2+ binding site [ion binding]; other site 361100007258 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 361100007259 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 361100007260 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 361100007261 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 361100007262 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 361100007263 NAD(P) binding site [chemical binding]; other site 361100007264 catalytic residues [active] 361100007265 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 361100007266 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 361100007267 inhibitor site; inhibition site 361100007268 active site 361100007269 dimer interface [polypeptide binding]; other site 361100007270 catalytic residue [active] 361100007271 Proline racemase; Region: Pro_racemase; pfam05544 361100007272 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 361100007273 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 361100007274 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 361100007275 hydroxyglutarate oxidase; Provisional; Region: PRK11728 361100007276 PAS domain; Region: PAS; smart00091 361100007277 PAS domain; Region: PAS_9; pfam13426 361100007278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100007279 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 361100007280 Walker A motif; other site 361100007281 ATP binding site [chemical binding]; other site 361100007282 Walker B motif; other site 361100007283 arginine finger; other site 361100007284 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 361100007285 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 361100007286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100007287 Walker A/P-loop; other site 361100007288 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 361100007289 catalytic loop [active] 361100007290 iron binding site [ion binding]; other site 361100007291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 361100007292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 361100007293 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 361100007294 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 361100007295 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 361100007296 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 361100007297 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 361100007298 DltD N-terminal region; Region: DltD_N; pfam04915 361100007299 DltD central region; Region: DltD_M; pfam04918 361100007300 DltD C-terminal region; Region: DltD_C; pfam04914 361100007301 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100007302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007303 Coenzyme A binding pocket [chemical binding]; other site 361100007304 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100007305 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100007306 peptide binding site [polypeptide binding]; other site 361100007307 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 361100007308 NlpC/P60 family; Region: NLPC_P60; pfam00877 361100007309 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 361100007310 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 361100007311 active site 361100007312 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 361100007313 Septum formation initiator; Region: DivIC; pfam04977 361100007314 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 361100007315 DJ-1 family protein; Region: not_thiJ; TIGR01383 361100007316 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 361100007317 conserved cys residue [active] 361100007318 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 361100007319 active site 361100007320 catalytic motif [active] 361100007321 Zn binding site [ion binding]; other site 361100007322 Methyltransferase domain; Region: Methyltransf_23; pfam13489 361100007323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100007324 S-adenosylmethionine binding site [chemical binding]; other site 361100007325 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 361100007326 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 361100007327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100007328 dimerization interface [polypeptide binding]; other site 361100007329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100007330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100007331 dimer interface [polypeptide binding]; other site 361100007332 phosphorylation site [posttranslational modification] 361100007333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100007334 ATP binding site [chemical binding]; other site 361100007335 Mg2+ binding site [ion binding]; other site 361100007336 G-X-G motif; other site 361100007337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100007338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100007339 active site 361100007340 phosphorylation site [posttranslational modification] 361100007341 intermolecular recognition site; other site 361100007342 dimerization interface [polypeptide binding]; other site 361100007343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100007344 DNA binding site [nucleotide binding] 361100007345 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 361100007346 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 361100007347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100007348 motif II; other site 361100007349 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 361100007350 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 361100007351 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 361100007352 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 361100007353 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 361100007354 Zn binding site [ion binding]; other site 361100007355 EDD domain protein, DegV family; Region: DegV; TIGR00762 361100007356 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 361100007357 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 361100007358 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 361100007359 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 361100007360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007361 Coenzyme A binding pocket [chemical binding]; other site 361100007362 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 361100007363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100007364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100007365 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100007366 putative substrate translocation pore; other site 361100007367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100007368 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 361100007369 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 361100007370 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 361100007371 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 361100007372 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 361100007373 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 361100007374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100007375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100007376 putative substrate translocation pore; other site 361100007377 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 361100007378 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 361100007379 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 361100007380 active site 361100007381 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 361100007382 Methyltransferase domain; Region: Methyltransf_31; pfam13847 361100007383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100007384 S-adenosylmethionine binding site [chemical binding]; other site 361100007385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100007386 putative substrate translocation pore; other site 361100007387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100007388 aspartate aminotransferase; Provisional; Region: PRK07681 361100007389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100007390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100007391 homodimer interface [polypeptide binding]; other site 361100007392 catalytic residue [active] 361100007393 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 361100007394 pantothenate kinase; Provisional; Region: PRK13317 361100007395 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 361100007396 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 361100007397 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 361100007398 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 361100007399 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 361100007400 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 361100007401 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 361100007402 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 361100007403 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 361100007404 Domain of unknown function DUF20; Region: UPF0118; pfam01594 361100007405 HNH endonuclease; Region: HNH_5; pfam14279 361100007406 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 361100007407 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 361100007408 active site 361100007409 dimer interface [polypeptide binding]; other site 361100007410 non-prolyl cis peptide bond; other site 361100007411 insertion regions; other site 361100007412 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 361100007413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 361100007414 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 361100007415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 361100007416 substrate binding pocket [chemical binding]; other site 361100007417 membrane-bound complex binding site; other site 361100007418 hinge residues; other site 361100007419 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 361100007420 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 361100007421 Walker A/P-loop; other site 361100007422 ATP binding site [chemical binding]; other site 361100007423 Q-loop/lid; other site 361100007424 ABC transporter signature motif; other site 361100007425 Walker B; other site 361100007426 D-loop; other site 361100007427 H-loop/switch region; other site 361100007428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100007429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100007430 Protein of unknown function (DUF402); Region: DUF402; pfam04167 361100007431 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 361100007432 nudix motif; other site 361100007433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 361100007434 binding surface 361100007435 TPR motif; other site 361100007436 hypothetical protein; Provisional; Region: PRK09620 361100007437 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 361100007438 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 361100007439 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 361100007440 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 361100007441 Coenzyme A binding pocket [chemical binding]; other site 361100007442 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 361100007443 DinB superfamily; Region: DinB_2; pfam12867 361100007444 Protein of unknown function (DUF664); Region: DUF664; pfam04978 361100007445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 361100007446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007447 Coenzyme A binding pocket [chemical binding]; other site 361100007448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100007449 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100007450 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 361100007451 active site 361100007452 NTP binding site [chemical binding]; other site 361100007453 metal binding triad [ion binding]; metal-binding site 361100007454 antibiotic binding site [chemical binding]; other site 361100007455 A new structural DNA glycosylase; Region: AlkD_like; cd06561 361100007456 active site 361100007457 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 361100007458 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 361100007459 NodB motif; other site 361100007460 active site 361100007461 catalytic site [active] 361100007462 Zn binding site [ion binding]; other site 361100007463 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 361100007464 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 361100007465 active site 361100007466 P-loop; other site 361100007467 phosphorylation site [posttranslational modification] 361100007468 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 361100007469 HTH domain; Region: HTH_11; pfam08279 361100007470 Mga helix-turn-helix domain; Region: Mga; pfam05043 361100007471 PRD domain; Region: PRD; pfam00874 361100007472 PRD domain; Region: PRD; pfam00874 361100007473 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 361100007474 active site 361100007475 P-loop; other site 361100007476 phosphorylation site [posttranslational modification] 361100007477 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 361100007478 active site 361100007479 phosphorylation site [posttranslational modification] 361100007480 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 361100007481 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 361100007482 Sulfatase; Region: Sulfatase; pfam00884 361100007483 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 361100007484 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100007485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100007486 ABC transporter; Region: ABC_tran_2; pfam12848 361100007487 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100007488 hypothetical protein; Provisional; Region: PRK06761 361100007489 MMPL family; Region: MMPL; pfam03176 361100007490 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 361100007491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100007492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100007493 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 361100007494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007495 Coenzyme A binding pocket [chemical binding]; other site 361100007496 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 361100007497 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 361100007498 active site 361100007499 hinge; other site 361100007500 prephenate dehydrogenase; Validated; Region: PRK06545 361100007501 prephenate dehydrogenase; Validated; Region: PRK08507 361100007502 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 361100007503 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 361100007504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100007505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100007506 homodimer interface [polypeptide binding]; other site 361100007507 catalytic residue [active] 361100007508 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 361100007509 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 361100007510 Tetramer interface [polypeptide binding]; other site 361100007511 active site 361100007512 FMN-binding site [chemical binding]; other site 361100007513 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 361100007514 Chorismate mutase type II; Region: CM_2; cl00693 361100007515 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 361100007516 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 361100007517 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 361100007518 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 361100007519 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100007520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007521 Coenzyme A binding pocket [chemical binding]; other site 361100007522 Isochorismatase family; Region: Isochorismatase; pfam00857 361100007523 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 361100007524 catalytic triad [active] 361100007525 conserved cis-peptide bond; other site 361100007526 YfzA-like protein; Region: YfzA; pfam14118 361100007527 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100007528 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100007529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 361100007530 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 361100007531 malate:quinone oxidoreductase; Validated; Region: PRK05257 361100007532 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 361100007533 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 361100007534 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 361100007535 ligand binding site [chemical binding]; other site 361100007536 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 361100007537 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 361100007538 TM-ABC transporter signature motif; other site 361100007539 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 361100007540 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 361100007541 TM-ABC transporter signature motif; other site 361100007542 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 361100007543 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 361100007544 Walker A/P-loop; other site 361100007545 ATP binding site [chemical binding]; other site 361100007546 Q-loop/lid; other site 361100007547 ABC transporter signature motif; other site 361100007548 Walker B; other site 361100007549 D-loop; other site 361100007550 H-loop/switch region; other site 361100007551 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 361100007552 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 361100007553 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 361100007554 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 361100007555 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 361100007556 putative N- and C-terminal domain interface [polypeptide binding]; other site 361100007557 putative active site [active] 361100007558 putative MgATP binding site [chemical binding]; other site 361100007559 catalytic site [active] 361100007560 metal binding site [ion binding]; metal-binding site 361100007561 putative carbohydrate binding site [chemical binding]; other site 361100007562 Cupin domain; Region: Cupin_2; pfam07883 361100007563 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 361100007564 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 361100007565 putative active site; other site 361100007566 catalytic residue [active] 361100007567 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 361100007568 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 361100007569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100007570 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100007571 putative substrate translocation pore; other site 361100007572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100007573 putative DNA binding site [nucleotide binding]; other site 361100007574 putative Zn2+ binding site [ion binding]; other site 361100007575 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 361100007576 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 361100007577 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 361100007578 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 361100007579 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 361100007580 putative catalytic cysteine [active] 361100007581 gamma-glutamyl kinase; Provisional; Region: PRK05429 361100007582 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 361100007583 nucleotide binding site [chemical binding]; other site 361100007584 homotetrameric interface [polypeptide binding]; other site 361100007585 putative phosphate binding site [ion binding]; other site 361100007586 putative allosteric binding site; other site 361100007587 PUA domain; Region: PUA; pfam01472 361100007588 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 361100007589 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 361100007590 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 361100007591 putative metal binding site [ion binding]; other site 361100007592 putative dimer interface [polypeptide binding]; other site 361100007593 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 361100007594 Transcriptional regulator [Transcription]; Region: IclR; COG1414 361100007595 Bacterial transcriptional regulator; Region: IclR; pfam01614 361100007596 S-methylmethionine transporter; Provisional; Region: PRK11387 361100007597 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 361100007598 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 361100007599 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 361100007600 putative di-iron ligands [ion binding]; other site 361100007601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 361100007602 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 361100007603 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 361100007604 dimer interface [polypeptide binding]; other site 361100007605 Alkaline phosphatase homologues; Region: alkPPc; smart00098 361100007606 active site 361100007607 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 361100007608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100007609 salt bridge; other site 361100007610 non-specific DNA binding site [nucleotide binding]; other site 361100007611 sequence-specific DNA binding site [nucleotide binding]; other site 361100007612 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 361100007613 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 361100007614 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 361100007615 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 361100007616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 361100007617 active site 361100007618 phosphorylation site [posttranslational modification] 361100007619 intermolecular recognition site; other site 361100007620 LytTr DNA-binding domain; Region: LytTR; pfam04397 361100007621 uridine kinase; Provisional; Region: PRK07667 361100007622 active site 361100007623 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100007624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100007626 Coenzyme A binding pocket [chemical binding]; other site 361100007627 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100007628 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 361100007629 active site 361100007630 metal binding site [ion binding]; metal-binding site 361100007631 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 361100007632 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100007633 Transcriptional regulator PadR-like family; Region: PadR; cl17335 361100007634 MoxR-like ATPases [General function prediction only]; Region: COG0714 361100007635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100007636 Walker A motif; other site 361100007637 ATP binding site [chemical binding]; other site 361100007638 Walker B motif; other site 361100007639 arginine finger; other site 361100007640 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 361100007641 Protein of unknown function DUF58; Region: DUF58; pfam01882 361100007642 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 361100007643 proline/glycine betaine transporter; Provisional; Region: PRK10642 361100007644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100007645 putative substrate translocation pore; other site 361100007646 acetylornithine aminotransferase; Provisional; Region: PRK02627 361100007647 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 361100007648 inhibitor-cofactor binding pocket; inhibition site 361100007649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100007650 catalytic residue [active] 361100007651 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 361100007652 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 361100007653 tetramer interface [polypeptide binding]; other site 361100007654 heme binding pocket [chemical binding]; other site 361100007655 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 361100007656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100007657 dimer interface [polypeptide binding]; other site 361100007658 conserved gate region; other site 361100007659 putative PBP binding loops; other site 361100007660 ABC-ATPase subunit interface; other site 361100007661 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 361100007662 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 361100007663 Walker A/P-loop; other site 361100007664 ATP binding site [chemical binding]; other site 361100007665 Q-loop/lid; other site 361100007666 ABC transporter signature motif; other site 361100007667 Walker B; other site 361100007668 D-loop; other site 361100007669 H-loop/switch region; other site 361100007670 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 361100007671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 361100007672 membrane-bound complex binding site; other site 361100007673 hinge residues; other site 361100007674 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 361100007675 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100007676 MarR family; Region: MarR_2; pfam12802 361100007677 adenine deaminase; Region: ade; TIGR01178 361100007678 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 361100007679 active site 361100007680 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 361100007681 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100007682 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100007683 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 361100007684 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 361100007685 Protein of unknown function DUF58; Region: DUF58; pfam01882 361100007686 MoxR-like ATPases [General function prediction only]; Region: COG0714 361100007687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100007688 Walker A motif; other site 361100007689 ATP binding site [chemical binding]; other site 361100007690 Walker B motif; other site 361100007691 arginine finger; other site 361100007692 Uncharacterized conserved protein [Function unknown]; Region: COG1359 361100007693 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 361100007694 dimer interface [polypeptide binding]; other site 361100007695 FMN binding site [chemical binding]; other site 361100007696 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100007697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100007698 putative DNA binding site [nucleotide binding]; other site 361100007699 putative Zn2+ binding site [ion binding]; other site 361100007700 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 361100007701 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 361100007702 G1 box; other site 361100007703 putative GEF interaction site [polypeptide binding]; other site 361100007704 GTP/Mg2+ binding site [chemical binding]; other site 361100007705 Switch I region; other site 361100007706 G2 box; other site 361100007707 G3 box; other site 361100007708 Switch II region; other site 361100007709 G4 box; other site 361100007710 G5 box; other site 361100007711 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 361100007712 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 361100007713 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 361100007714 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 361100007715 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 361100007716 nudix motif; other site 361100007717 YfzA-like protein; Region: YfzA; pfam14118 361100007718 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 361100007719 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100007720 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100007721 Walker A/P-loop; other site 361100007722 ATP binding site [chemical binding]; other site 361100007723 Q-loop/lid; other site 361100007724 ABC transporter signature motif; other site 361100007725 Walker B; other site 361100007726 D-loop; other site 361100007727 H-loop/switch region; other site 361100007728 Predicted transcriptional regulators [Transcription]; Region: COG1725 361100007729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100007730 DNA-binding site [nucleotide binding]; DNA binding site 361100007731 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 361100007732 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 361100007733 putative NAD(P) binding site [chemical binding]; other site 361100007734 active site 361100007735 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100007736 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100007737 Walker A/P-loop; other site 361100007738 ATP binding site [chemical binding]; other site 361100007739 Q-loop/lid; other site 361100007740 ABC transporter signature motif; other site 361100007741 Walker B; other site 361100007742 D-loop; other site 361100007743 H-loop/switch region; other site 361100007744 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 361100007745 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100007746 FtsX-like permease family; Region: FtsX; pfam02687 361100007747 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 361100007748 FtsX-like permease family; Region: FtsX; pfam02687 361100007749 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100007750 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100007751 Walker A/P-loop; other site 361100007752 ATP binding site [chemical binding]; other site 361100007753 Q-loop/lid; other site 361100007754 ABC transporter signature motif; other site 361100007755 Walker B; other site 361100007756 D-loop; other site 361100007757 H-loop/switch region; other site 361100007758 FtsX-like permease family; Region: FtsX; pfam02687 361100007759 FtsX-like permease family; Region: FtsX; pfam02687 361100007760 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100007761 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100007762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 361100007763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100007764 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 361100007765 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100007766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007767 Coenzyme A binding pocket [chemical binding]; other site 361100007768 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 361100007769 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 361100007770 nudix motif; other site 361100007771 EamA-like transporter family; Region: EamA; pfam00892 361100007772 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 361100007773 EamA-like transporter family; Region: EamA; pfam00892 361100007774 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 361100007775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100007776 DNA-binding site [nucleotide binding]; DNA binding site 361100007777 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100007778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100007779 homodimer interface [polypeptide binding]; other site 361100007780 catalytic residue [active] 361100007781 hypothetical protein; Validated; Region: PRK00124 361100007782 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 361100007783 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 361100007784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100007785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100007786 phosphorylation site [posttranslational modification] 361100007787 dimer interface [polypeptide binding]; other site 361100007788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100007789 ATP binding site [chemical binding]; other site 361100007790 Mg2+ binding site [ion binding]; other site 361100007791 G-X-G motif; other site 361100007792 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100007793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100007794 active site 361100007795 phosphorylation site [posttranslational modification] 361100007796 intermolecular recognition site; other site 361100007797 dimerization interface [polypeptide binding]; other site 361100007798 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100007799 DNA binding site [nucleotide binding] 361100007800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100007801 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 361100007802 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 361100007803 uridine kinase; Validated; Region: PRK06696 361100007804 AAA domain; Region: AAA_18; pfam13238 361100007805 active site 361100007806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100007807 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 361100007808 active site 361100007809 metal binding site [ion binding]; metal-binding site 361100007810 Phosphotransferase enzyme family; Region: APH; pfam01636 361100007811 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 361100007812 active site 361100007813 substrate binding site [chemical binding]; other site 361100007814 ATP binding site [chemical binding]; other site 361100007815 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 361100007816 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 361100007817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100007818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007819 Coenzyme A binding pocket [chemical binding]; other site 361100007820 lysine transporter; Provisional; Region: PRK10836 361100007821 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 361100007822 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 361100007823 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100007824 DNA binding residues [nucleotide binding] 361100007825 dimer interface [polypeptide binding]; other site 361100007826 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 361100007827 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 361100007828 Integrase core domain; Region: rve; pfam00665 361100007829 transposase/IS protein; Provisional; Region: PRK09183 361100007830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100007831 Walker A motif; other site 361100007832 ATP binding site [chemical binding]; other site 361100007833 Walker B motif; other site 361100007834 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 361100007835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100007836 S-adenosylmethionine binding site [chemical binding]; other site 361100007837 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 361100007838 FIC domain binding interface [polypeptide binding]; other site 361100007839 Cache domain; Region: Cache_2; cl07034 361100007840 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 361100007841 putative active site [active] 361100007842 nucleotide binding site [chemical binding]; other site 361100007843 nudix motif; other site 361100007844 putative metal binding site [ion binding]; other site 361100007845 Cephalosporin hydroxylase; Region: CmcI; pfam04989 361100007846 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 361100007847 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 361100007848 Catalytic site [active] 361100007849 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 361100007850 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100007851 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100007852 NAD-dependent deacetylase; Provisional; Region: PRK00481 361100007853 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 361100007854 NAD+ binding site [chemical binding]; other site 361100007855 substrate binding site [chemical binding]; other site 361100007856 Zn binding site [ion binding]; other site 361100007857 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 361100007858 putative substrate binding pocket [chemical binding]; other site 361100007859 AC domain interface; other site 361100007860 catalytic triad [active] 361100007861 AB domain interface; other site 361100007862 interchain disulfide; other site 361100007863 Predicted membrane protein [Function unknown]; Region: COG3817 361100007864 Protein of unknown function (DUF979); Region: DUF979; pfam06166 361100007865 Protein of unknown function (DUF969); Region: DUF969; pfam06149 361100007866 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 361100007867 putative active site [active] 361100007868 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 361100007869 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 361100007870 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 361100007871 Transcriptional regulator [Transcription]; Region: IclR; COG1414 361100007872 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 361100007873 Bacterial transcriptional regulator; Region: IclR; pfam01614 361100007874 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 361100007875 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 361100007876 Catalytic site [active] 361100007877 CutC family; Region: CutC; cl01218 361100007878 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 361100007879 stage II sporulation protein P; Region: spore_II_P; TIGR02867 361100007880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100007881 dimerization interface [polypeptide binding]; other site 361100007882 putative DNA binding site [nucleotide binding]; other site 361100007883 putative Zn2+ binding site [ion binding]; other site 361100007884 DinB superfamily; Region: DinB_2; pfam12867 361100007885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100007886 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100007887 putative substrate translocation pore; other site 361100007888 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 361100007889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 361100007890 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 361100007891 Uncharacterized conserved protein [Function unknown]; Region: COG1434 361100007892 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 361100007893 putative active site [active] 361100007894 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100007895 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100007896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 361100007897 Nucleoside recognition; Region: Gate; pfam07670 361100007898 S-layer homology domain; Region: SLH; pfam00395 361100007899 S-layer homology domain; Region: SLH; pfam00395 361100007900 S-layer homology domain; Region: SLH; pfam00395 361100007901 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 361100007902 putative active site [active] 361100007903 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 361100007904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100007905 Coenzyme A binding pocket [chemical binding]; other site 361100007906 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 361100007907 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 361100007908 Ferritin-like domain; Region: Ferritin; pfam00210 361100007909 dinuclear metal binding motif [ion binding]; other site 361100007910 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 361100007911 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 361100007912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100007913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100007914 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 361100007915 phosphoenolpyruvate synthase; Validated; Region: PRK06241 361100007916 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 361100007917 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 361100007918 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 361100007919 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100007920 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 361100007921 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 361100007922 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 361100007923 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 361100007924 LysE type translocator; Region: LysE; pfam01810 361100007925 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 361100007926 Spore germination protein; Region: Spore_permease; cl17796 361100007927 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 361100007928 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 361100007929 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 361100007930 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 361100007931 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 361100007932 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 361100007933 NAD binding site [chemical binding]; other site 361100007934 catalytic Zn binding site [ion binding]; other site 361100007935 structural Zn binding site [ion binding]; other site 361100007936 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 361100007937 dimanganese center [ion binding]; other site 361100007938 aspartate ammonia-lyase; Provisional; Region: PRK14515 361100007939 Aspartase; Region: Aspartase; cd01357 361100007940 active sites [active] 361100007941 tetramer interface [polypeptide binding]; other site 361100007942 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 361100007943 active site 361100007944 homodimer interface [polypeptide binding]; other site 361100007945 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100007946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100007947 non-specific DNA binding site [nucleotide binding]; other site 361100007948 salt bridge; other site 361100007949 sequence-specific DNA binding site [nucleotide binding]; other site 361100007950 Integrase core domain; Region: rve_3; cl15866 361100007951 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 361100007952 GIY-YIG motif/motif A; other site 361100007953 active site 361100007954 catalytic site [active] 361100007955 putative DNA binding site [nucleotide binding]; other site 361100007956 metal binding site [ion binding]; metal-binding site 361100007957 amino acid transporter; Region: 2A0306; TIGR00909 361100007958 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 361100007959 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 361100007960 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 361100007961 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100007962 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100007963 Spore germination protein; Region: Spore_permease; pfam03845 361100007964 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100007965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100007966 Response regulator receiver domain; Region: Response_reg; pfam00072 361100007967 active site 361100007968 phosphorylation site [posttranslational modification] 361100007969 intermolecular recognition site; other site 361100007970 dimerization interface [polypeptide binding]; other site 361100007971 YcbB domain; Region: YcbB; pfam08664 361100007972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100007973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100007974 ATP binding site [chemical binding]; other site 361100007975 Mg2+ binding site [ion binding]; other site 361100007976 G-X-G motif; other site 361100007977 glutaminase; Reviewed; Region: PRK12357 361100007978 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 361100007979 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 361100007980 amino acid carrier protein; Region: agcS; TIGR00835 361100007981 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 361100007982 transmembrane helices; other site 361100007983 Cytochrome P450; Region: p450; cl12078 361100007984 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100007985 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100007986 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 361100007987 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 361100007988 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 361100007989 [2Fe-2S] cluster binding site [ion binding]; other site 361100007990 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 361100007991 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 361100007992 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 361100007993 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 361100007994 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 361100007995 putative active site [active] 361100007996 putative metal binding site [ion binding]; other site 361100007997 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 361100007998 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 361100007999 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 361100008000 tetramer interface [polypeptide binding]; other site 361100008001 heme binding pocket [chemical binding]; other site 361100008002 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 361100008003 Cl binding site [ion binding]; other site 361100008004 oligomer interface [polypeptide binding]; other site 361100008005 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 361100008006 plasmid segregation protein ParM; Provisional; Region: PRK13917 361100008007 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 361100008008 Mg binding site [ion binding]; other site 361100008009 nucleotide binding site [chemical binding]; other site 361100008010 putative protofilament interface [polypeptide binding]; other site 361100008011 Heat induced stress protein YflT; Region: YflT; pfam11181 361100008012 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 361100008013 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 361100008014 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 361100008015 TspO/MBR family; Region: TspO_MBR; pfam03073 361100008016 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 361100008017 DNA photolyase; Region: DNA_photolyase; pfam00875 361100008018 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 361100008019 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 361100008020 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 361100008021 active site clefts [active] 361100008022 Carbonic anhydrase; Region: Pro_CA; pfam00484 361100008023 zinc binding site [ion binding]; other site 361100008024 dimer interface [polypeptide binding]; other site 361100008025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 361100008026 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 361100008027 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 361100008028 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 361100008029 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 361100008030 Spore germination protein; Region: Spore_permease; cl17796 361100008031 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100008032 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100008033 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100008034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100008035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100008036 Coenzyme A binding pocket [chemical binding]; other site 361100008037 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 361100008038 UbiA prenyltransferase family; Region: UbiA; pfam01040 361100008039 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 361100008040 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 361100008041 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100008042 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100008043 Walker A/P-loop; other site 361100008044 ATP binding site [chemical binding]; other site 361100008045 Q-loop/lid; other site 361100008046 ABC transporter signature motif; other site 361100008047 Walker B; other site 361100008048 D-loop; other site 361100008049 H-loop/switch region; other site 361100008050 FtsX-like permease family; Region: FtsX; pfam02687 361100008051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 361100008052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100008053 ATP binding site [chemical binding]; other site 361100008054 Mg2+ binding site [ion binding]; other site 361100008055 G-X-G motif; other site 361100008056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100008057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100008058 active site 361100008059 dimerization interface [polypeptide binding]; other site 361100008060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100008061 DNA binding residues [nucleotide binding] 361100008062 dimerization interface [polypeptide binding]; other site 361100008063 DJ-1 family protein; Region: not_thiJ; TIGR01383 361100008064 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 361100008065 conserved cys residue [active] 361100008066 Phosphotransferase enzyme family; Region: APH; pfam01636 361100008067 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 361100008068 active site 361100008069 ATP binding site [chemical binding]; other site 361100008070 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 361100008071 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 361100008072 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 361100008073 short chain dehydrogenase; Validated; Region: PRK08324 361100008074 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 361100008075 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 361100008076 putative NAD(P) binding site [chemical binding]; other site 361100008077 active site 361100008078 L-fucose isomerase; Provisional; Region: fucI; PRK10991 361100008079 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 361100008080 hexamer (dimer of trimers) interface [polypeptide binding]; other site 361100008081 trimer interface [polypeptide binding]; other site 361100008082 substrate binding site [chemical binding]; other site 361100008083 Mn binding site [ion binding]; other site 361100008084 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 361100008085 N- and C-terminal domain interface [polypeptide binding]; other site 361100008086 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 361100008087 active site 361100008088 putative catalytic site [active] 361100008089 metal binding site [ion binding]; metal-binding site 361100008090 ATP binding site [chemical binding]; other site 361100008091 carbohydrate binding site [chemical binding]; other site 361100008092 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 361100008093 active site 361100008094 intersubunit interface [polypeptide binding]; other site 361100008095 Zn2+ binding site [ion binding]; other site 361100008096 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 361100008097 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 361100008098 putative ligand binding site [chemical binding]; other site 361100008099 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 361100008100 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 361100008101 TM-ABC transporter signature motif; other site 361100008102 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 361100008103 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 361100008104 Walker A/P-loop; other site 361100008105 ATP binding site [chemical binding]; other site 361100008106 Q-loop/lid; other site 361100008107 ABC transporter signature motif; other site 361100008108 Walker B; other site 361100008109 D-loop; other site 361100008110 H-loop/switch region; other site 361100008111 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 361100008112 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 361100008113 Transcriptional regulators [Transcription]; Region: PurR; COG1609 361100008114 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 361100008115 DNA binding site [nucleotide binding] 361100008116 domain linker motif; other site 361100008117 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 361100008118 dimerization interface [polypeptide binding]; other site 361100008119 ligand binding site [chemical binding]; other site 361100008120 Protein of unknown function DUF262; Region: DUF262; pfam03235 361100008121 Uncharacterized conserved protein [Function unknown]; Region: COG1479 361100008122 Protein of unknown function DUF262; Region: DUF262; pfam03235 361100008123 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 361100008124 Low molecular weight phosphatase family; Region: LMWPc; cd00115 361100008125 active site 361100008126 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 361100008127 arsenical-resistance protein; Region: acr3; TIGR00832 361100008128 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100008129 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 361100008130 putative metal binding site [ion binding]; other site 361100008131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100008132 dimerization interface [polypeptide binding]; other site 361100008133 putative DNA binding site [nucleotide binding]; other site 361100008134 putative Zn2+ binding site [ion binding]; other site 361100008135 DinB superfamily; Region: DinB_2; pfam12867 361100008136 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 361100008137 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 361100008138 RibD C-terminal domain; Region: RibD_C; cl17279 361100008139 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 361100008140 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 361100008141 FtsX-like permease family; Region: FtsX; pfam02687 361100008142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 361100008143 FtsX-like permease family; Region: FtsX; pfam02687 361100008144 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100008145 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100008146 Walker A/P-loop; other site 361100008147 ATP binding site [chemical binding]; other site 361100008148 Q-loop/lid; other site 361100008149 ABC transporter signature motif; other site 361100008150 Walker B; other site 361100008151 D-loop; other site 361100008152 H-loop/switch region; other site 361100008153 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 361100008154 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 361100008155 active site 361100008156 NTP binding site [chemical binding]; other site 361100008157 metal binding triad [ion binding]; metal-binding site 361100008158 antibiotic binding site [chemical binding]; other site 361100008159 HEPN domain; Region: HEPN; cl00824 361100008160 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 361100008161 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 361100008162 putative NAD(P) binding site [chemical binding]; other site 361100008163 active site 361100008164 putative substrate binding site [chemical binding]; other site 361100008165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100008166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100008167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100008168 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 361100008169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008170 putative substrate translocation pore; other site 361100008171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100008172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100008173 short chain dehydrogenase; Provisional; Region: PRK12746 361100008174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100008175 NAD(P) binding site [chemical binding]; other site 361100008176 active site 361100008177 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 361100008178 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100008179 putative DNA binding site [nucleotide binding]; other site 361100008180 putative Zn2+ binding site [ion binding]; other site 361100008181 AsnC family; Region: AsnC_trans_reg; pfam01037 361100008182 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 361100008183 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 361100008184 metal binding site [ion binding]; metal-binding site 361100008185 AAA domain; Region: AAA_11; pfam13086 361100008186 Part of AAA domain; Region: AAA_19; pfam13245 361100008187 Erp protein C-terminus; Region: Erp_C; pfam06780 361100008188 AAA domain; Region: AAA_30; pfam13604 361100008189 AAA domain; Region: AAA_12; pfam13087 361100008190 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 361100008191 putative active site [active] 361100008192 catalytic site [active] 361100008193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100008194 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 361100008195 active site 361100008196 metal binding site [ion binding]; metal-binding site 361100008197 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 361100008198 putative monooxygenase; Provisional; Region: PRK11118 361100008199 DoxX-like family; Region: DoxX_2; pfam13564 361100008200 Transcriptional regulators [Transcription]; Region: MarR; COG1846 361100008201 MarR family; Region: MarR_2; pfam12802 361100008202 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 361100008203 Cytochrome P450; Region: p450; pfam00067 361100008204 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 361100008205 Flavodoxin; Region: Flavodoxin_1; pfam00258 361100008206 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 361100008207 FAD binding pocket [chemical binding]; other site 361100008208 FAD binding motif [chemical binding]; other site 361100008209 catalytic residues [active] 361100008210 NAD binding pocket [chemical binding]; other site 361100008211 phosphate binding motif [ion binding]; other site 361100008212 beta-alpha-beta structure motif; other site 361100008213 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 361100008214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008215 putative substrate translocation pore; other site 361100008216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008217 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 361100008218 ATP-grasp domain; Region: ATP-grasp_4; cl17255 361100008219 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100008220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008221 putative substrate translocation pore; other site 361100008222 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 361100008223 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 361100008224 D-cysteine desulfhydrase; Validated; Region: PRK03910 361100008225 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 361100008226 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100008227 catalytic residue [active] 361100008228 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 361100008229 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100008230 active site 361100008231 metal binding site [ion binding]; metal-binding site 361100008232 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 361100008233 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 361100008234 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 361100008235 CAAX protease self-immunity; Region: Abi; pfam02517 361100008236 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 361100008237 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100008238 DNA binding residues [nucleotide binding] 361100008239 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 361100008240 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 361100008241 hypothetical protein; Provisional; Region: PRK06762 361100008242 AAA domain; Region: AAA_33; pfam13671 361100008243 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 361100008244 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100008245 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100008246 Walker A/P-loop; other site 361100008247 ATP binding site [chemical binding]; other site 361100008248 Q-loop/lid; other site 361100008249 ABC transporter signature motif; other site 361100008250 Walker B; other site 361100008251 D-loop; other site 361100008252 H-loop/switch region; other site 361100008253 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 361100008254 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100008255 FtsX-like permease family; Region: FtsX; pfam02687 361100008256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100008257 dimerization interface [polypeptide binding]; other site 361100008258 putative DNA binding site [nucleotide binding]; other site 361100008259 putative Zn2+ binding site [ion binding]; other site 361100008260 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100008261 DinB superfamily; Region: DinB_2; pfam12867 361100008262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100008263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100008264 dimerization interface [polypeptide binding]; other site 361100008265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100008266 dimer interface [polypeptide binding]; other site 361100008267 phosphorylation site [posttranslational modification] 361100008268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100008269 ATP binding site [chemical binding]; other site 361100008270 Mg2+ binding site [ion binding]; other site 361100008271 G-X-G motif; other site 361100008272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100008273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100008274 active site 361100008275 phosphorylation site [posttranslational modification] 361100008276 intermolecular recognition site; other site 361100008277 dimerization interface [polypeptide binding]; other site 361100008278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100008279 DNA binding site [nucleotide binding] 361100008280 Predicted membrane protein [Function unknown]; Region: COG2364 361100008281 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100008282 Transcriptional regulators [Transcription]; Region: MarR; COG1846 361100008283 MarR family; Region: MarR; pfam01047 361100008284 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 361100008285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100008286 Coenzyme A binding pocket [chemical binding]; other site 361100008287 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 361100008288 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100008289 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100008290 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100008291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008292 D-galactonate transporter; Region: 2A0114; TIGR00893 361100008293 putative substrate translocation pore; other site 361100008294 Uncharacterized conserved protein [Function unknown]; Region: COG1556 361100008295 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 361100008296 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 361100008297 4Fe-4S binding domain; Region: Fer4; pfam00037 361100008298 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 361100008299 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 361100008300 Cysteine-rich domain; Region: CCG; pfam02754 361100008301 Cysteine-rich domain; Region: CCG; pfam02754 361100008302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100008303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100008304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 361100008305 dimerization interface [polypeptide binding]; other site 361100008306 2TM domain; Region: 2TM; pfam13239 361100008307 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 361100008308 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 361100008309 putative dimer interface [polypeptide binding]; other site 361100008310 catalytic triad [active] 361100008311 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 361100008312 Uncharacterized conserved protein [Function unknown]; Region: COG4198 361100008313 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 361100008314 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 361100008315 glyoxylate reductase; Reviewed; Region: PRK13243 361100008316 putative ligand binding site [chemical binding]; other site 361100008317 putative NAD binding site [chemical binding]; other site 361100008318 putative catalytic site [active] 361100008319 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 361100008320 L-serine binding site [chemical binding]; other site 361100008321 ACT domain interface; other site 361100008322 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 361100008323 homodimer interface [polypeptide binding]; other site 361100008324 substrate-cofactor binding pocket; other site 361100008325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100008326 catalytic residue [active] 361100008327 Cupin domain; Region: Cupin_2; cl17218 361100008328 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 361100008329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100008330 Penicillin amidase; Region: Penicil_amidase; pfam01804 361100008331 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 361100008332 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 361100008333 active site 361100008334 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 361100008335 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 361100008336 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 361100008337 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 361100008338 amidase catalytic site [active] 361100008339 Zn binding residues [ion binding]; other site 361100008340 substrate binding site [chemical binding]; other site 361100008341 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100008342 S-layer homology domain; Region: SLH; pfam00395 361100008343 S-layer homology domain; Region: SLH; pfam00395 361100008344 S-layer homology domain; Region: SLH; pfam00395 361100008345 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 361100008346 A new structural DNA glycosylase; Region: AlkD_like; cd06561 361100008347 active site 361100008348 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 361100008349 S-layer homology domain; Region: SLH; pfam00395 361100008350 S-layer homology domain; Region: SLH; pfam00395 361100008351 S-layer homology domain; Region: SLH; pfam00395 361100008352 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 361100008353 putative metal binding site [ion binding]; other site 361100008354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100008355 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 361100008356 NETI protein; Region: NETI; pfam14044 361100008357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100008359 putative substrate translocation pore; other site 361100008360 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100008361 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 361100008362 TAP-like protein; Region: Abhydrolase_4; pfam08386 361100008363 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100008364 MarR family; Region: MarR_2; pfam12802 361100008365 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100008366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008367 putative substrate translocation pore; other site 361100008368 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100008369 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100008370 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 361100008371 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100008372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100008373 Walker A/P-loop; other site 361100008374 ATP binding site [chemical binding]; other site 361100008375 Q-loop/lid; other site 361100008376 ABC transporter signature motif; other site 361100008377 Walker B; other site 361100008378 D-loop; other site 361100008379 H-loop/switch region; other site 361100008380 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 361100008381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100008382 putative DNA binding site [nucleotide binding]; other site 361100008383 putative Zn2+ binding site [ion binding]; other site 361100008384 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 361100008385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100008386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100008387 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 361100008388 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 361100008389 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 361100008390 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 361100008391 SWIM zinc finger; Region: SWIM; pfam04434 361100008392 YwiC-like protein; Region: YwiC; pfam14256 361100008393 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 361100008394 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 361100008395 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 361100008396 Walker A/P-loop; other site 361100008397 ATP binding site [chemical binding]; other site 361100008398 Q-loop/lid; other site 361100008399 ABC transporter signature motif; other site 361100008400 Walker B; other site 361100008401 D-loop; other site 361100008402 H-loop/switch region; other site 361100008403 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 361100008404 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 361100008405 Walker A/P-loop; other site 361100008406 ATP binding site [chemical binding]; other site 361100008407 Q-loop/lid; other site 361100008408 ABC transporter signature motif; other site 361100008409 Walker B; other site 361100008410 D-loop; other site 361100008411 H-loop/switch region; other site 361100008412 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 361100008413 Calreticulin family; Region: Calreticulin; pfam00262 361100008414 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 361100008415 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 361100008416 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 361100008417 Predicted membrane protein [Function unknown]; Region: COG1288 361100008418 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 361100008419 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 361100008420 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 361100008421 DNA binding residues [nucleotide binding] 361100008422 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100008423 dimer interface [polypeptide binding]; other site 361100008424 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 361100008425 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 361100008426 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 361100008427 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100008428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100008429 non-specific DNA binding site [nucleotide binding]; other site 361100008430 salt bridge; other site 361100008431 sequence-specific DNA binding site [nucleotide binding]; other site 361100008432 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 361100008433 nudix motif; other site 361100008434 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 361100008435 putative deacylase active site [active] 361100008436 histidyl-tRNA synthetase; Provisional; Region: PRK12420 361100008437 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 361100008438 dimer interface [polypeptide binding]; other site 361100008439 motif 1; other site 361100008440 active site 361100008441 motif 2; other site 361100008442 motif 3; other site 361100008443 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 361100008444 anticodon binding site; other site 361100008445 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100008446 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 361100008447 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 361100008448 dimer interface [polypeptide binding]; other site 361100008449 FMN binding site [chemical binding]; other site 361100008450 pyruvate kinase; Validated; Region: PRK06739 361100008451 active site 361100008452 domain interfaces; other site 361100008453 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 361100008454 classical (c) SDRs; Region: SDR_c; cd05233 361100008455 NAD(P) binding site [chemical binding]; other site 361100008456 active site 361100008457 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 361100008458 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100008459 Walker A/P-loop; other site 361100008460 ATP binding site [chemical binding]; other site 361100008461 Q-loop/lid; other site 361100008462 ABC transporter signature motif; other site 361100008463 Walker B; other site 361100008464 D-loop; other site 361100008465 H-loop/switch region; other site 361100008466 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 361100008467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100008468 non-specific DNA binding site [nucleotide binding]; other site 361100008469 salt bridge; other site 361100008470 sequence-specific DNA binding site [nucleotide binding]; other site 361100008471 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 361100008472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100008473 motif II; other site 361100008474 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 361100008475 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 361100008476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100008477 Coenzyme A binding pocket [chemical binding]; other site 361100008478 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 361100008479 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 361100008480 nudix motif; other site 361100008481 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 361100008482 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100008483 putative metal binding site [ion binding]; other site 361100008484 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 361100008485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 361100008486 maltose O-acetyltransferase; Provisional; Region: PRK10092 361100008487 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 361100008488 active site 361100008489 substrate binding site [chemical binding]; other site 361100008490 trimer interface [polypeptide binding]; other site 361100008491 CoA binding site [chemical binding]; other site 361100008492 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 361100008493 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 361100008494 active site 361100008495 HIGH motif; other site 361100008496 dimer interface [polypeptide binding]; other site 361100008497 KMSKS motif; other site 361100008498 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 361100008499 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 361100008500 Domain of unknown function DUF20; Region: UPF0118; pfam01594 361100008501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100008502 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 361100008503 Coenzyme A binding pocket [chemical binding]; other site 361100008504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100008505 S-adenosylmethionine binding site [chemical binding]; other site 361100008506 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 361100008507 CGNR zinc finger; Region: zf-CGNR; pfam11706 361100008508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100008510 putative substrate translocation pore; other site 361100008511 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 361100008512 hypothetical protein; Provisional; Region: PRK04164 361100008513 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100008514 ATP synthase I chain; Region: ATP_synt_I; cl09170 361100008515 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 361100008516 Domain of unknown function DUF21; Region: DUF21; pfam01595 361100008517 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 361100008518 Transporter associated domain; Region: CorC_HlyC; smart01091 361100008519 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 361100008520 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 361100008521 DNA binding residues [nucleotide binding] 361100008522 putative dimer interface [polypeptide binding]; other site 361100008523 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 361100008524 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 361100008525 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 361100008526 substrate binding site; other site 361100008527 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 361100008528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100008529 NAD(P) binding site [chemical binding]; other site 361100008530 active site 361100008531 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 361100008532 Methyltransferase domain; Region: Methyltransf_23; pfam13489 361100008533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100008534 S-adenosylmethionine binding site [chemical binding]; other site 361100008535 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 361100008536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100008537 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 361100008538 NAD(P) binding site [chemical binding]; other site 361100008539 active site 361100008540 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 361100008541 Variant SH3 domain; Region: SH3_2; pfam07653 361100008542 peptide ligand binding site [polypeptide binding]; other site 361100008543 Src Homology 3 domain superfamily; Region: SH3; cl17036 361100008544 EamA-like transporter family; Region: EamA; pfam00892 361100008545 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 361100008546 EamA-like transporter family; Region: EamA; pfam00892 361100008547 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 361100008548 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 361100008549 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 361100008550 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 361100008551 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 361100008552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 361100008553 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 361100008554 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 361100008555 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 361100008556 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 361100008557 N- and C-terminal domain interface [polypeptide binding]; other site 361100008558 active site 361100008559 catalytic site [active] 361100008560 metal binding site [ion binding]; metal-binding site 361100008561 carbohydrate binding site [chemical binding]; other site 361100008562 ATP binding site [chemical binding]; other site 361100008563 GntP family permease; Region: GntP_permease; pfam02447 361100008564 fructuronate transporter; Provisional; Region: PRK10034; cl15264 361100008565 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 361100008566 active site 361100008567 intersubunit interactions; other site 361100008568 catalytic residue [active] 361100008569 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 361100008570 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 361100008571 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 361100008572 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 361100008573 TPP-binding site [chemical binding]; other site 361100008574 dimer interface [polypeptide binding]; other site 361100008575 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 361100008576 PYR/PP interface [polypeptide binding]; other site 361100008577 dimer interface [polypeptide binding]; other site 361100008578 TPP binding site [chemical binding]; other site 361100008579 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 361100008580 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 361100008581 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 361100008582 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 361100008583 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 361100008584 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 361100008585 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 361100008586 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 361100008587 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 361100008588 putative NAD(P) binding site [chemical binding]; other site 361100008589 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 361100008590 classical (c) SDRs; Region: SDR_c; cd05233 361100008591 NAD(P) binding site [chemical binding]; other site 361100008592 active site 361100008593 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 361100008594 dimer interface [polypeptide binding]; other site 361100008595 FMN binding site [chemical binding]; other site 361100008596 BNR repeat-like domain; Region: BNR_2; pfam13088 361100008597 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 361100008598 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 361100008599 active site 361100008600 catalytic tetrad [active] 361100008601 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 361100008602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008603 putative substrate translocation pore; other site 361100008604 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 361100008605 active site 1 [active] 361100008606 dimer interface [polypeptide binding]; other site 361100008607 hexamer interface [polypeptide binding]; other site 361100008608 active site 2 [active] 361100008609 dimer interface [polypeptide binding]; other site 361100008610 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 361100008611 hexamer interface [polypeptide binding]; other site 361100008612 active site 2 [active] 361100008613 hypothetical protein; Provisional; Region: PRK02487 361100008614 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100008615 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 361100008616 active site 361100008617 metal binding site [ion binding]; metal-binding site 361100008618 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 361100008619 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 361100008620 IDEAL domain; Region: IDEAL; pfam08858 361100008621 Transcriptional regulator; Region: Rrf2; pfam02082 361100008622 Rrf2 family protein; Region: rrf2_super; TIGR00738 361100008623 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 361100008624 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 361100008625 ArsC family; Region: ArsC; pfam03960 361100008626 putative catalytic residues [active] 361100008627 thiol/disulfide switch; other site 361100008628 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100008629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100008630 dimerization interface [polypeptide binding]; other site 361100008631 putative DNA binding site [nucleotide binding]; other site 361100008632 putative Zn2+ binding site [ion binding]; other site 361100008633 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 361100008634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100008635 DNA-binding site [nucleotide binding]; DNA binding site 361100008636 UTRA domain; Region: UTRA; pfam07702 361100008637 putative oxidoreductase; Provisional; Region: PRK10206 361100008638 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 361100008639 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 361100008640 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 361100008641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 361100008642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100008643 S-adenosylmethionine binding site [chemical binding]; other site 361100008644 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100008645 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 361100008646 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100008647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100008648 dimerization interface [polypeptide binding]; other site 361100008649 putative DNA binding site [nucleotide binding]; other site 361100008650 putative Zn2+ binding site [ion binding]; other site 361100008651 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 361100008652 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 361100008653 active site 361100008654 catalytic tetrad [active] 361100008655 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 361100008656 putative hydrophobic ligand binding site [chemical binding]; other site 361100008657 protein interface [polypeptide binding]; other site 361100008658 gate; other site 361100008659 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 361100008660 catalytic triad [active] 361100008661 oxyanion hole [active] 361100008662 active site 361100008663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100008664 Phosphotransferase enzyme family; Region: APH; pfam01636 361100008665 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 361100008666 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 361100008667 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 361100008668 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 361100008669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100008670 Coenzyme A binding pocket [chemical binding]; other site 361100008671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100008672 short chain dehydrogenase; Provisional; Region: PRK12828 361100008673 NAD(P) binding site [chemical binding]; other site 361100008674 active site 361100008675 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100008676 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100008677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100008678 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100008679 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 361100008680 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 361100008681 acyl-activating enzyme (AAE) consensus motif; other site 361100008682 AMP binding site [chemical binding]; other site 361100008683 active site 361100008684 CoA binding site [chemical binding]; other site 361100008685 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 361100008686 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100008687 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100008688 dimerization interface [polypeptide binding]; other site 361100008689 putative DNA binding site [nucleotide binding]; other site 361100008690 putative Zn2+ binding site [ion binding]; other site 361100008691 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100008692 dimerization interface [polypeptide binding]; other site 361100008693 putative DNA binding site [nucleotide binding]; other site 361100008694 putative Zn2+ binding site [ion binding]; other site 361100008695 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 361100008696 active site 361100008697 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 361100008698 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 361100008699 NodB motif; other site 361100008700 putative active site [active] 361100008701 putative catalytic site [active] 361100008702 putative Zn binding site [ion binding]; other site 361100008703 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 361100008704 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 361100008705 DXD motif; other site 361100008706 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 361100008707 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 361100008708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100008709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 361100008710 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 361100008711 active site 361100008712 hypothetical protein; Provisional; Region: PRK12856 361100008713 CAAX protease self-immunity; Region: Abi; cl00558 361100008714 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100008715 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100008716 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 361100008717 Predicted transcriptional regulator [Transcription]; Region: COG2378 361100008718 HTH domain; Region: HTH_11; pfam08279 361100008719 WYL domain; Region: WYL; pfam13280 361100008720 ABC-2 type transporter; Region: ABC2_membrane; cl17235 361100008721 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 361100008722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100008723 Walker A/P-loop; other site 361100008724 ATP binding site [chemical binding]; other site 361100008725 Q-loop/lid; other site 361100008726 ABC transporter signature motif; other site 361100008727 Walker B; other site 361100008728 D-loop; other site 361100008729 H-loop/switch region; other site 361100008730 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 361100008731 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100008732 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 361100008733 hydroxylamine reductase; Provisional; Region: PRK12310 361100008734 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 361100008735 ACS interaction site; other site 361100008736 CODH interaction site; other site 361100008737 metal cluster binding site [ion binding]; other site 361100008738 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 361100008739 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100008740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100008741 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 361100008742 metal binding site [ion binding]; metal-binding site 361100008743 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 361100008744 hypothetical protein; Provisional; Region: PRK06771 361100008745 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100008746 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100008747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 361100008748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 361100008749 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 361100008750 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100008751 active site 361100008752 metal binding site [ion binding]; metal-binding site 361100008753 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 361100008754 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 361100008755 ligand binding site [chemical binding]; other site 361100008756 flexible hinge region; other site 361100008757 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 361100008758 Protein of unknown function, DUF606; Region: DUF606; pfam04657 361100008759 Protein of unknown function, DUF606; Region: DUF606; pfam04657 361100008760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100008761 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 361100008762 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 361100008763 putative NAD(P) binding site [chemical binding]; other site 361100008764 dimer interface [polypeptide binding]; other site 361100008765 putative transport protein YifK; Provisional; Region: PRK10746 361100008766 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 361100008767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008768 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 361100008769 putative substrate translocation pore; other site 361100008770 Haemolysin XhlA; Region: XhlA; pfam10779 361100008771 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 361100008772 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 361100008773 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 361100008774 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 361100008775 transmembrane helices; other site 361100008776 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 361100008777 putative ligand binding residues [chemical binding]; other site 361100008778 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 361100008779 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 361100008780 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100008781 ABC-ATPase subunit interface; other site 361100008782 dimer interface [polypeptide binding]; other site 361100008783 putative PBP binding regions; other site 361100008784 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 361100008785 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100008786 ABC-ATPase subunit interface; other site 361100008787 dimer interface [polypeptide binding]; other site 361100008788 putative PBP binding regions; other site 361100008789 Protein of unknown function (DUF817); Region: DUF817; pfam05675 361100008790 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 361100008791 DinB superfamily; Region: DinB_2; pfam12867 361100008792 DinB family; Region: DinB; cl17821 361100008793 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100008794 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100008795 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 361100008796 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 361100008797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100008798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100008799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 361100008800 dimerization interface [polypeptide binding]; other site 361100008801 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 361100008802 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 361100008803 NADP binding site [chemical binding]; other site 361100008804 dimer interface [polypeptide binding]; other site 361100008805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 361100008806 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 361100008807 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 361100008808 catalytic core [active] 361100008809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100008810 Coenzyme A binding pocket [chemical binding]; other site 361100008811 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 361100008812 MutS domain III; Region: MutS_III; pfam05192 361100008813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100008814 Walker A/P-loop; other site 361100008815 ATP binding site [chemical binding]; other site 361100008816 Q-loop/lid; other site 361100008817 ABC transporter signature motif; other site 361100008818 Walker B; other site 361100008819 D-loop; other site 361100008820 H-loop/switch region; other site 361100008821 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 361100008822 oligoendopeptidase F; Region: pepF; TIGR00181 361100008823 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 361100008824 active site 361100008825 Zn binding site [ion binding]; other site 361100008826 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100008827 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100008828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100008829 putative substrate translocation pore; other site 361100008830 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100008831 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100008832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100008833 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 361100008834 putative dimerization interface [polypeptide binding]; other site 361100008835 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 361100008836 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 361100008837 putative active site [active] 361100008838 Probable transposase; Region: OrfB_IS605; pfam01385 361100008839 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 361100008840 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 361100008841 Transposase IS200 like; Region: Y1_Tnp; pfam01797 361100008842 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100008843 dimerization interface [polypeptide binding]; other site 361100008844 putative DNA binding site [nucleotide binding]; other site 361100008845 putative Zn2+ binding site [ion binding]; other site 361100008846 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 361100008847 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 361100008848 putative NAD(P) binding site [chemical binding]; other site 361100008849 Uncharacterized conserved protein [Function unknown]; Region: COG0397 361100008850 hypothetical protein; Validated; Region: PRK00029 361100008851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100008852 binding surface 361100008853 TPR motif; other site 361100008854 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100008855 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100008856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100008857 TPR motif; other site 361100008858 binding surface 361100008859 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 361100008860 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 361100008861 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 361100008862 Sodium Bile acid symporter family; Region: SBF; cl17470 361100008863 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 361100008864 FAD binding domain; Region: FAD_binding_4; pfam01565 361100008865 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 361100008866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100008867 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100008868 potential frameshift: common BLAST hit: gi|67077952|ref|YP_245572.1| transposase 361100008869 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 361100008870 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 361100008871 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 361100008872 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 361100008873 FOG: PKD repeat [General function prediction only]; Region: COG3291 361100008874 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 361100008875 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 361100008876 MgtC family; Region: MgtC; pfam02308 361100008877 Predicted acetyltransferase [General function prediction only]; Region: COG3981 361100008878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100008879 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 361100008880 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 361100008881 putative metal binding site [ion binding]; other site 361100008882 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 361100008883 active site 361100008884 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 361100008885 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 361100008886 substrate binding pocket [chemical binding]; other site 361100008887 membrane-bound complex binding site; other site 361100008888 hinge residues; other site 361100008889 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 361100008890 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 361100008891 Walker A/P-loop; other site 361100008892 ATP binding site [chemical binding]; other site 361100008893 Q-loop/lid; other site 361100008894 ABC transporter signature motif; other site 361100008895 Walker B; other site 361100008896 D-loop; other site 361100008897 H-loop/switch region; other site 361100008898 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 361100008899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100008900 dimer interface [polypeptide binding]; other site 361100008901 conserved gate region; other site 361100008902 putative PBP binding loops; other site 361100008903 ABC-ATPase subunit interface; other site 361100008904 VanW like protein; Region: VanW; pfam04294 361100008905 Sensor protein DegS; Region: DegS; pfam05384 361100008906 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 361100008907 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 361100008908 exonuclease; Provisional; Region: PRK06722 361100008909 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 361100008910 active site 361100008911 substrate binding site [chemical binding]; other site 361100008912 catalytic site [active] 361100008913 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 361100008914 DNA-binding site [nucleotide binding]; DNA binding site 361100008915 RNA-binding motif; other site 361100008916 flavodoxin; Provisional; Region: PRK06703 361100008917 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 361100008918 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 361100008919 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 361100008920 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 361100008921 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 361100008922 catalytic residues [active] 361100008923 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 361100008924 nudix motif; other site 361100008925 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 361100008926 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 361100008927 trimer interface [polypeptide binding]; other site 361100008928 active site 361100008929 substrate binding site [chemical binding]; other site 361100008930 CoA binding site [chemical binding]; other site 361100008931 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008932 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008933 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008934 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008935 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008936 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008937 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008938 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008939 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008940 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008941 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008942 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008943 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008944 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100008945 short chain dehydrogenase; Provisional; Region: PRK06924 361100008946 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 361100008947 NADP binding site [chemical binding]; other site 361100008948 homodimer interface [polypeptide binding]; other site 361100008949 active site 361100008950 Predicted acetyltransferase [General function prediction only]; Region: COG3393 361100008951 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100008952 argininosuccinate lyase; Provisional; Region: PRK06705 361100008953 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 361100008954 active sites [active] 361100008955 tetramer interface [polypeptide binding]; other site 361100008956 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100008957 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100008958 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 361100008959 active site 361100008960 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 361100008961 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 361100008962 Na binding site [ion binding]; other site 361100008963 Protein of unknown function (DUF997); Region: DUF997; pfam06196 361100008964 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 361100008965 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 361100008966 NAD(P) binding site [chemical binding]; other site 361100008967 catalytic residues [active] 361100008968 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 361100008969 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 361100008970 NAD(P) binding site [chemical binding]; other site 361100008971 homotetramer interface [polypeptide binding]; other site 361100008972 homodimer interface [polypeptide binding]; other site 361100008973 active site 361100008974 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 361100008975 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 361100008976 Divergent PAP2 family; Region: DUF212; pfam02681 361100008977 Predicted permeases [General function prediction only]; Region: RarD; COG2962 361100008978 EamA-like transporter family; Region: EamA; pfam00892 361100008979 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 361100008980 Domain of unknown function DUF59; Region: DUF59; cl00941 361100008981 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 361100008982 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 361100008983 Walker A motif; other site 361100008984 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 361100008985 MoaE interaction surface [polypeptide binding]; other site 361100008986 MoeB interaction surface [polypeptide binding]; other site 361100008987 thiocarboxylated glycine; other site 361100008988 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 361100008989 MoaE homodimer interface [polypeptide binding]; other site 361100008990 MoaD interaction [polypeptide binding]; other site 361100008991 active site residues [active] 361100008992 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 361100008993 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 361100008994 dimer interface [polypeptide binding]; other site 361100008995 putative functional site; other site 361100008996 putative MPT binding site; other site 361100008997 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 361100008998 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 361100008999 ATP binding site [chemical binding]; other site 361100009000 substrate interface [chemical binding]; other site 361100009001 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 361100009002 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 361100009003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100009004 FeS/SAM binding site; other site 361100009005 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 361100009006 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 361100009007 Uncharacterized conserved protein [Function unknown]; Region: COG5609 361100009008 Uncharacterized conserved protein [Function unknown]; Region: COG2427 361100009009 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 361100009010 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 361100009011 catalytic loop [active] 361100009012 iron binding site [ion binding]; other site 361100009013 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 361100009014 4Fe-4S binding domain; Region: Fer4; pfam00037 361100009015 4Fe-4S binding domain; Region: Fer4; pfam00037 361100009016 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 361100009017 [4Fe-4S] binding site [ion binding]; other site 361100009018 molybdopterin cofactor binding site; other site 361100009019 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 361100009020 molybdopterin cofactor binding site; other site 361100009021 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100009022 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 361100009023 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100009024 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100009025 Tubulin like; Region: Tubulin_2; pfam13809 361100009026 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 361100009027 metal ion-dependent adhesion site (MIDAS); other site 361100009028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100009029 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 361100009030 active site 361100009031 metal binding site [ion binding]; metal-binding site 361100009032 Methyltransferase domain; Region: Methyltransf_31; pfam13847 361100009033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100009034 S-adenosylmethionine binding site [chemical binding]; other site 361100009035 O-methyltransferase; Region: Methyltransf_2; pfam00891 361100009036 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100009037 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100009038 peptide binding site [polypeptide binding]; other site 361100009039 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100009040 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100009041 peptide binding site [polypeptide binding]; other site 361100009042 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 361100009043 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 361100009044 peptide binding site [polypeptide binding]; other site 361100009045 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 361100009046 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 361100009047 Transcriptional regulator [Transcription]; Region: LytR; COG1316 361100009048 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 361100009049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100009050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100009051 DNA binding residues [nucleotide binding] 361100009052 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 361100009053 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100009054 active site 361100009055 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 361100009056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100009057 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100009058 Walker A/P-loop; other site 361100009059 ATP binding site [chemical binding]; other site 361100009060 Q-loop/lid; other site 361100009061 ABC transporter signature motif; other site 361100009062 Walker B; other site 361100009063 D-loop; other site 361100009064 H-loop/switch region; other site 361100009065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100009066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100009067 putative oxidoreductase; Provisional; Region: PRK11579 361100009068 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 361100009069 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 361100009070 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 361100009071 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 361100009072 CAP-like domain; other site 361100009073 active site 361100009074 primary dimer interface [polypeptide binding]; other site 361100009075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100009076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100009077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100009078 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 361100009079 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 361100009080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100009081 ATP binding site [chemical binding]; other site 361100009082 Mg2+ binding site [ion binding]; other site 361100009083 G-X-G motif; other site 361100009084 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 361100009085 anchoring element; other site 361100009086 dimer interface [polypeptide binding]; other site 361100009087 ATP binding site [chemical binding]; other site 361100009088 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 361100009089 active site 361100009090 putative metal-binding site [ion binding]; other site 361100009091 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 361100009092 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 361100009093 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 361100009094 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 361100009095 protein binding site [polypeptide binding]; other site 361100009096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100009097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100009098 active site 361100009099 phosphorylation site [posttranslational modification] 361100009100 intermolecular recognition site; other site 361100009101 dimerization interface [polypeptide binding]; other site 361100009102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100009103 DNA binding site [nucleotide binding] 361100009104 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 361100009105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100009106 FeS/SAM binding site; other site 361100009107 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 361100009108 Class III ribonucleotide reductase; Region: RNR_III; cd01675 361100009109 effector binding site; other site 361100009110 active site 361100009111 Zn binding site [ion binding]; other site 361100009112 glycine loop; other site 361100009113 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 361100009114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 361100009115 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 361100009116 active site 361100009117 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 361100009118 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 361100009119 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 361100009120 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 361100009121 active site 361100009122 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 361100009123 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 361100009124 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 361100009125 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 361100009126 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 361100009127 active site 361100009128 catalytic site [active] 361100009129 substrate binding site [chemical binding]; other site 361100009130 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 361100009131 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 361100009132 catalytic residues [active] 361100009133 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 361100009134 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100009135 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 361100009136 Walker A/P-loop; other site 361100009137 ATP binding site [chemical binding]; other site 361100009138 ABC transporter signature motif; other site 361100009139 Walker B; other site 361100009140 D-loop; other site 361100009141 H-loop/switch region; other site 361100009142 aconitate hydratase; Validated; Region: PRK09277 361100009143 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 361100009144 substrate binding site [chemical binding]; other site 361100009145 ligand binding site [chemical binding]; other site 361100009146 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 361100009147 substrate binding site [chemical binding]; other site 361100009148 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 361100009149 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 361100009150 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 361100009151 NodB motif; other site 361100009152 active site 361100009153 catalytic site [active] 361100009154 metal binding site [ion binding]; metal-binding site 361100009155 Small acid-soluble spore protein P family; Region: SspP; cl12105 361100009156 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 361100009157 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 361100009158 putative dimer interface [polypeptide binding]; other site 361100009159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100009160 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 361100009161 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 361100009162 active site 361100009163 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 361100009164 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 361100009165 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 361100009166 nudix motif; other site 361100009167 SAP domain; Region: SAP; pfam02037 361100009168 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100009169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100009170 non-specific DNA binding site [nucleotide binding]; other site 361100009171 salt bridge; other site 361100009172 sequence-specific DNA binding site [nucleotide binding]; other site 361100009173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100009174 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 361100009175 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 361100009176 dimer interface [polypeptide binding]; other site 361100009177 active site 361100009178 acyl-CoA synthetase; Validated; Region: PRK07638 361100009179 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 361100009180 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 361100009181 acyl-activating enzyme (AAE) consensus motif; other site 361100009182 acyl-activating enzyme (AAE) consensus motif; other site 361100009183 AMP binding site [chemical binding]; other site 361100009184 active site 361100009185 CoA binding site [chemical binding]; other site 361100009186 BioY family; Region: BioY; pfam02632 361100009187 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 361100009188 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 361100009189 dimer interface [polypeptide binding]; other site 361100009190 acyl-activating enzyme (AAE) consensus motif; other site 361100009191 putative active site [active] 361100009192 AMP binding site [chemical binding]; other site 361100009193 putative CoA binding site [chemical binding]; other site 361100009194 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 361100009195 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100009196 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100009197 Walker A/P-loop; other site 361100009198 ATP binding site [chemical binding]; other site 361100009199 Q-loop/lid; other site 361100009200 ABC transporter signature motif; other site 361100009201 Walker B; other site 361100009202 D-loop; other site 361100009203 H-loop/switch region; other site 361100009204 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100009205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100009206 non-specific DNA binding site [nucleotide binding]; other site 361100009207 salt bridge; other site 361100009208 sequence-specific DNA binding site [nucleotide binding]; other site 361100009209 S-layer homology domain; Region: SLH; pfam00395 361100009210 S-layer homology domain; Region: SLH; pfam00395 361100009211 S-layer homology domain; Region: SLH; pfam00395 361100009212 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 361100009213 active site 361100009214 catalytic motif [active] 361100009215 Zn binding site [ion binding]; other site 361100009216 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 361100009217 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 361100009218 amidase catalytic site [active] 361100009219 Zn binding residues [ion binding]; other site 361100009220 substrate binding site [chemical binding]; other site 361100009221 active site 361100009222 Protein phosphatase 2C; Region: PP2C_2; pfam13672 361100009223 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100009224 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100009225 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100009226 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 361100009227 dimer interface [polypeptide binding]; other site 361100009228 putative metal binding site [ion binding]; other site 361100009229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100009230 PAS domain; Region: PAS_9; pfam13426 361100009231 putative active site [active] 361100009232 heme pocket [chemical binding]; other site 361100009233 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 361100009234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100009235 putative active site [active] 361100009236 heme pocket [chemical binding]; other site 361100009237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100009238 dimer interface [polypeptide binding]; other site 361100009239 phosphorylation site [posttranslational modification] 361100009240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100009241 ATP binding site [chemical binding]; other site 361100009242 Mg2+ binding site [ion binding]; other site 361100009243 G-X-G motif; other site 361100009244 Predicted esterase [General function prediction only]; Region: COG0400 361100009245 putative hydrolase; Provisional; Region: PRK11460 361100009246 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 361100009247 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100009248 Zn binding site [ion binding]; other site 361100009249 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 361100009250 Zn binding site [ion binding]; other site 361100009251 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 361100009252 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 361100009253 Na binding site [ion binding]; other site 361100009254 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 361100009255 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 361100009256 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 361100009257 active site 361100009258 FMN binding site [chemical binding]; other site 361100009259 substrate binding site [chemical binding]; other site 361100009260 3Fe-4S cluster binding site [ion binding]; other site 361100009261 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 361100009262 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 361100009263 FMN binding site [chemical binding]; other site 361100009264 active site 361100009265 substrate binding site [chemical binding]; other site 361100009266 catalytic residue [active] 361100009267 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 361100009268 agmatinase; Region: agmatinase; TIGR01230 361100009269 Agmatinase-like family; Region: Agmatinase-like; cd09990 361100009270 active site 361100009271 oligomer interface [polypeptide binding]; other site 361100009272 Mn binding site [ion binding]; other site 361100009273 imidazolonepropionase; Validated; Region: PRK09356 361100009274 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 361100009275 active site 361100009276 urocanate hydratase; Provisional; Region: PRK05414 361100009277 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 361100009278 active sites [active] 361100009279 tetramer interface [polypeptide binding]; other site 361100009280 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 361100009281 hexamer interface [polypeptide binding]; other site 361100009282 RNA binding site [nucleotide binding]; other site 361100009283 Histidine-zinc binding site [chemical binding]; other site 361100009284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100009285 S-adenosylmethionine binding site [chemical binding]; other site 361100009286 DJ-1 family protein; Region: not_thiJ; TIGR01383 361100009287 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 361100009288 conserved cys residue [active] 361100009289 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 361100009290 AAA domain; Region: AAA_28; pfam13521 361100009291 active site 361100009292 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 361100009293 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009294 Domain of unknown function DUF11; Region: DUF11; cl17728 361100009295 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009296 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009297 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009298 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009299 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009300 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009301 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009302 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009303 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009304 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009305 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009306 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009307 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009308 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009309 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 361100009310 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 361100009311 putative active site [active] 361100009312 putative NTP binding site [chemical binding]; other site 361100009313 putative nucleic acid binding site [nucleotide binding]; other site 361100009314 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 361100009315 active site 361100009316 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009317 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009318 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100009319 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 361100009320 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 361100009321 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 361100009322 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 361100009323 EamA-like transporter family; Region: EamA; pfam00892 361100009324 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 361100009325 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 361100009326 metal binding site [ion binding]; metal-binding site 361100009327 dimer interface [polypeptide binding]; other site 361100009328 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 361100009329 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 361100009330 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100009331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100009332 Walker A/P-loop; other site 361100009333 ATP binding site [chemical binding]; other site 361100009334 Q-loop/lid; other site 361100009335 ABC transporter signature motif; other site 361100009336 Walker B; other site 361100009337 D-loop; other site 361100009338 H-loop/switch region; other site 361100009339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100009340 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 361100009341 putative dimerization interface [polypeptide binding]; other site 361100009342 putative substrate binding pocket [chemical binding]; other site 361100009343 holin-like protein; Validated; Region: PRK01658 361100009344 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 361100009345 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 361100009346 nudix motif; other site 361100009347 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 361100009348 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 361100009349 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 361100009350 amidase catalytic site [active] 361100009351 Zn binding residues [ion binding]; other site 361100009352 substrate binding site [chemical binding]; other site 361100009353 S-layer homology domain; Region: SLH; pfam00395 361100009354 S-layer homology domain; Region: SLH; pfam00395 361100009355 S-layer homology domain; Region: SLH; pfam00395 361100009356 Nuclease-related domain; Region: NERD; pfam08378 361100009357 Bacterial SH3 domain; Region: SH3_3; cl17532 361100009358 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 361100009359 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100009360 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 361100009361 Walker A/P-loop; other site 361100009362 ATP binding site [chemical binding]; other site 361100009363 Q-loop/lid; other site 361100009364 ABC transporter signature motif; other site 361100009365 Walker B; other site 361100009366 D-loop; other site 361100009367 H-loop/switch region; other site 361100009368 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100009369 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 361100009370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100009371 Walker A/P-loop; other site 361100009372 ATP binding site [chemical binding]; other site 361100009373 Q-loop/lid; other site 361100009374 ABC transporter signature motif; other site 361100009375 Walker B; other site 361100009376 D-loop; other site 361100009377 H-loop/switch region; other site 361100009378 hypothetical protein; Provisional; Region: PRK01844 361100009379 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 361100009380 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 361100009381 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 361100009382 TPP-binding site [chemical binding]; other site 361100009383 dimer interface [polypeptide binding]; other site 361100009384 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 361100009385 PYR/PP interface [polypeptide binding]; other site 361100009386 dimer interface [polypeptide binding]; other site 361100009387 TPP binding site [chemical binding]; other site 361100009388 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 361100009389 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 361100009390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100009391 dimer interface [polypeptide binding]; other site 361100009392 conserved gate region; other site 361100009393 ABC-ATPase subunit interface; other site 361100009394 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 361100009395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100009396 dimer interface [polypeptide binding]; other site 361100009397 conserved gate region; other site 361100009398 ABC-ATPase subunit interface; other site 361100009399 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 361100009400 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 361100009401 Q-loop/lid; other site 361100009402 ABC transporter signature motif; other site 361100009403 Walker B; other site 361100009404 D-loop; other site 361100009405 H-loop/switch region; other site 361100009406 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 361100009407 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 361100009408 membrane-bound complex binding site; other site 361100009409 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 361100009410 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 361100009411 active site 361100009412 metal binding site [ion binding]; metal-binding site 361100009413 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 361100009414 hypothetical protein; Provisional; Region: PRK01546 361100009415 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100009416 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 361100009417 catalytic residues [active] 361100009418 catalytic nucleophile [active] 361100009419 LexA repressor; Validated; Region: PRK00215 361100009420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100009421 putative DNA binding site [nucleotide binding]; other site 361100009422 putative Zn2+ binding site [ion binding]; other site 361100009423 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 361100009424 Catalytic site [active] 361100009425 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 361100009426 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 361100009427 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 361100009428 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100009429 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 361100009430 glutamine synthetase, type I; Region: GlnA; TIGR00653 361100009431 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 361100009432 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 361100009433 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 361100009434 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100009435 DNA binding residues [nucleotide binding] 361100009436 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 361100009437 Aluminium resistance protein; Region: Alum_res; pfam06838 361100009438 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 361100009439 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 361100009440 HflX GTPase family; Region: HflX; cd01878 361100009441 G1 box; other site 361100009442 GTP/Mg2+ binding site [chemical binding]; other site 361100009443 Switch I region; other site 361100009444 G2 box; other site 361100009445 G3 box; other site 361100009446 Switch II region; other site 361100009447 G4 box; other site 361100009448 G5 box; other site 361100009449 Predicted membrane protein [Function unknown]; Region: COG2860 361100009450 UPF0126 domain; Region: UPF0126; pfam03458 361100009451 UPF0126 domain; Region: UPF0126; pfam03458 361100009452 stage V sporulation protein K; Region: spore_V_K; TIGR02881 361100009453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100009454 Walker A motif; other site 361100009455 ATP binding site [chemical binding]; other site 361100009456 Walker B motif; other site 361100009457 arginine finger; other site 361100009458 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 361100009459 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 361100009460 active site 361100009461 catalytic residues [active] 361100009462 DNA binding site [nucleotide binding] 361100009463 Int/Topo IB signature motif; other site 361100009464 potential frameshift: common BLAST hit: gi|49478336|ref|YP_037777.1| triple helix repeat-containing collagen 361100009465 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 361100009466 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 361100009467 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 361100009468 bacterial Hfq-like; Region: Hfq; cd01716 361100009469 hexamer interface [polypeptide binding]; other site 361100009470 Sm1 motif; other site 361100009471 RNA binding site [nucleotide binding]; other site 361100009472 Sm2 motif; other site 361100009473 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 361100009474 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 361100009475 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100009476 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100009477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 361100009478 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 361100009479 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 361100009480 active site 361100009481 phosphorylation site [posttranslational modification] 361100009482 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 361100009483 active site 361100009484 P-loop; other site 361100009485 phosphorylation site [posttranslational modification] 361100009486 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 361100009487 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 361100009488 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 361100009489 putative substrate binding site [chemical binding]; other site 361100009490 putative ATP binding site [chemical binding]; other site 361100009491 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 361100009492 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 361100009493 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 361100009494 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 361100009495 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 361100009496 dimer interface [polypeptide binding]; other site 361100009497 active site 361100009498 metal binding site [ion binding]; metal-binding site 361100009499 Predicted membrane protein [Function unknown]; Region: COG2322 361100009500 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 361100009501 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 361100009502 Glyco_18 domain; Region: Glyco_18; smart00636 361100009503 putative active site [active] 361100009504 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 361100009505 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100009506 putative active site [active] 361100009507 putative metal binding site [ion binding]; other site 361100009508 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 361100009509 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 361100009510 IHF dimer interface [polypeptide binding]; other site 361100009511 IHF - DNA interface [nucleotide binding]; other site 361100009512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100009513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100009514 Coenzyme A binding pocket [chemical binding]; other site 361100009515 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 361100009516 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 361100009517 metal-binding site [ion binding] 361100009518 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 361100009519 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 361100009520 metal-binding site [ion binding] 361100009521 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 361100009522 Soluble P-type ATPase [General function prediction only]; Region: COG4087 361100009523 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 361100009524 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 361100009525 metal-binding site [ion binding] 361100009526 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 361100009527 putative homodimer interface [polypeptide binding]; other site 361100009528 putative homotetramer interface [polypeptide binding]; other site 361100009529 allosteric switch controlling residues; other site 361100009530 putative metal binding site [ion binding]; other site 361100009531 putative homodimer-homodimer interface [polypeptide binding]; other site 361100009532 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 361100009533 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 361100009534 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 361100009535 Walker A/P-loop; other site 361100009536 ATP binding site [chemical binding]; other site 361100009537 Q-loop/lid; other site 361100009538 ABC transporter signature motif; other site 361100009539 Walker B; other site 361100009540 D-loop; other site 361100009541 H-loop/switch region; other site 361100009542 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 361100009543 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100009544 ABC-ATPase subunit interface; other site 361100009545 dimer interface [polypeptide binding]; other site 361100009546 putative PBP binding regions; other site 361100009547 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 361100009548 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100009549 ABC-ATPase subunit interface; other site 361100009550 dimer interface [polypeptide binding]; other site 361100009551 putative PBP binding regions; other site 361100009552 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 361100009553 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 361100009554 putative ligand binding residues [chemical binding]; other site 361100009555 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 361100009556 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 361100009557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100009558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100009559 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 361100009560 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 361100009561 DNA binding site [nucleotide binding] 361100009562 active site 361100009563 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 361100009564 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 361100009565 endonuclease III; Region: ENDO3c; smart00478 361100009566 minor groove reading motif; other site 361100009567 helix-hairpin-helix signature motif; other site 361100009568 substrate binding pocket [chemical binding]; other site 361100009569 active site 361100009570 peptidase T; Region: peptidase-T; TIGR01882 361100009571 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 361100009572 metal binding site [ion binding]; metal-binding site 361100009573 dimer interface [polypeptide binding]; other site 361100009574 Predicted membrane protein [Function unknown]; Region: COG2364 361100009575 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100009576 hypothetical protein; Provisional; Region: PRK06764 361100009577 PAS domain S-box; Region: sensory_box; TIGR00229 361100009578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100009579 putative active site [active] 361100009580 heme pocket [chemical binding]; other site 361100009581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 361100009582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 361100009583 metal binding site [ion binding]; metal-binding site 361100009584 active site 361100009585 I-site; other site 361100009586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 361100009587 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 361100009588 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 361100009589 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 361100009590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100009591 DNA-binding site [nucleotide binding]; DNA binding site 361100009592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100009593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100009594 homodimer interface [polypeptide binding]; other site 361100009595 catalytic residue [active] 361100009596 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 361100009597 active site 361100009598 catalytic site [active] 361100009599 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 361100009600 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 361100009601 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 361100009602 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 361100009603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 361100009604 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 361100009605 Sulfatase; Region: Sulfatase; pfam00884 361100009606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100009607 binding surface 361100009608 Tetratricopeptide repeat; Region: TPR_16; pfam13432 361100009609 TPR motif; other site 361100009610 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 361100009611 G1 box; other site 361100009612 GTP/Mg2+ binding site [chemical binding]; other site 361100009613 Switch I region; other site 361100009614 G3 box; other site 361100009615 Switch II region; other site 361100009616 G4 box; other site 361100009617 G5 box; other site 361100009618 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 361100009619 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 361100009620 active site 361100009621 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 361100009622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100009623 ATP binding site [chemical binding]; other site 361100009624 Mg2+ binding site [ion binding]; other site 361100009625 G-X-G motif; other site 361100009626 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 361100009627 ATP binding site [chemical binding]; other site 361100009628 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 361100009629 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 361100009630 MutS domain I; Region: MutS_I; pfam01624 361100009631 MutS domain II; Region: MutS_II; pfam05188 361100009632 MutS domain III; Region: MutS_III; pfam05192 361100009633 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 361100009634 Walker A/P-loop; other site 361100009635 ATP binding site [chemical binding]; other site 361100009636 Q-loop/lid; other site 361100009637 ABC transporter signature motif; other site 361100009638 Walker B; other site 361100009639 D-loop; other site 361100009640 H-loop/switch region; other site 361100009641 Outer spore coat protein E (CotE); Region: CotE; pfam10628 361100009642 Predicted membrane protein [Function unknown]; Region: COG4550 361100009643 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 361100009644 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 361100009645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100009646 FeS/SAM binding site; other site 361100009647 TRAM domain; Region: TRAM; pfam01938 361100009648 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 361100009649 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 361100009650 TPP-binding site [chemical binding]; other site 361100009651 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 361100009652 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 361100009653 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 361100009654 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 361100009655 dimer interface [polypeptide binding]; other site 361100009656 PYR/PP interface [polypeptide binding]; other site 361100009657 TPP binding site [chemical binding]; other site 361100009658 substrate binding site [chemical binding]; other site 361100009659 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 361100009660 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 361100009661 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 361100009662 active site 361100009663 dimer interface [polypeptide binding]; other site 361100009664 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 361100009665 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 361100009666 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 361100009667 putative active site [active] 361100009668 metal binding site [ion binding]; metal-binding site 361100009669 homodimer binding site [polypeptide binding]; other site 361100009670 phosphodiesterase; Provisional; Region: PRK12704 361100009671 Uncharacterized conserved protein [Function unknown]; Region: COG3334 361100009672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100009673 Zn2+ binding site [ion binding]; other site 361100009674 Mg2+ binding site [ion binding]; other site 361100009675 recA bacterial DNA recombination protein; Region: RecA; cl17211 361100009676 recA bacterial DNA recombination protein; Region: RecA; cl17211 361100009677 competence damage-inducible protein A; Provisional; Region: PRK00549 361100009678 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 361100009679 putative MPT binding site; other site 361100009680 Competence-damaged protein; Region: CinA; pfam02464 361100009681 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 361100009682 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 361100009683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100009684 non-specific DNA binding site [nucleotide binding]; other site 361100009685 salt bridge; other site 361100009686 sequence-specific DNA binding site [nucleotide binding]; other site 361100009687 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 361100009688 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 361100009689 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 361100009690 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 361100009691 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 361100009692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100009693 NAD(P) binding site [chemical binding]; other site 361100009694 active site 361100009695 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 361100009696 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 361100009697 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 361100009698 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 361100009699 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 361100009700 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 361100009701 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 361100009702 TM-ABC transporter signature motif; other site 361100009703 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 361100009704 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 361100009705 TM-ABC transporter signature motif; other site 361100009706 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 361100009707 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 361100009708 Walker A/P-loop; other site 361100009709 ATP binding site [chemical binding]; other site 361100009710 Q-loop/lid; other site 361100009711 ABC transporter signature motif; other site 361100009712 Walker B; other site 361100009713 D-loop; other site 361100009714 H-loop/switch region; other site 361100009715 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 361100009716 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 361100009717 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 361100009718 ligand binding site [chemical binding]; other site 361100009719 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 361100009720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100009721 DNA-binding site [nucleotide binding]; DNA binding site 361100009722 UTRA domain; Region: UTRA; pfam07702 361100009723 Tetraspanin family; Region: Tetraspannin; pfam00335 361100009724 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 361100009725 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 361100009726 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 361100009727 YlzJ-like protein; Region: YlzJ; pfam14035 361100009728 Clp protease; Region: CLP_protease; pfam00574 361100009729 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 361100009730 active site 361100009731 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 361100009732 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100009733 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 361100009734 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 361100009735 dihydrodipicolinate synthase; Region: dapA; TIGR00674 361100009736 dimer interface [polypeptide binding]; other site 361100009737 active site 361100009738 catalytic residue [active] 361100009739 aspartate kinase I; Reviewed; Region: PRK08210 361100009740 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 361100009741 nucleotide binding site [chemical binding]; other site 361100009742 substrate binding site [chemical binding]; other site 361100009743 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 361100009744 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 361100009745 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 361100009746 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 361100009747 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 361100009748 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 361100009749 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 361100009750 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 361100009751 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 361100009752 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 361100009753 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 361100009754 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 361100009755 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 361100009756 NodB motif; other site 361100009757 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 361100009758 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 361100009759 RNase E interface [polypeptide binding]; other site 361100009760 trimer interface [polypeptide binding]; other site 361100009761 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 361100009762 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 361100009763 RNase E interface [polypeptide binding]; other site 361100009764 trimer interface [polypeptide binding]; other site 361100009765 active site 361100009766 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 361100009767 putative nucleic acid binding region [nucleotide binding]; other site 361100009768 G-X-X-G motif; other site 361100009769 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 361100009770 RNA binding site [nucleotide binding]; other site 361100009771 domain interface; other site 361100009772 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 361100009773 16S/18S rRNA binding site [nucleotide binding]; other site 361100009774 S13e-L30e interaction site [polypeptide binding]; other site 361100009775 25S rRNA binding site [nucleotide binding]; other site 361100009776 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 361100009777 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 361100009778 active site 361100009779 Riboflavin kinase; Region: Flavokinase; smart00904 361100009780 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 361100009781 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 361100009782 RNA binding site [nucleotide binding]; other site 361100009783 active site 361100009784 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 361100009785 Protein of unknown function (DUF503); Region: DUF503; pfam04456 361100009786 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 361100009787 translation initiation factor IF-2; Region: IF-2; TIGR00487 361100009788 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 361100009789 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 361100009790 G1 box; other site 361100009791 putative GEF interaction site [polypeptide binding]; other site 361100009792 GTP/Mg2+ binding site [chemical binding]; other site 361100009793 Switch I region; other site 361100009794 G2 box; other site 361100009795 G3 box; other site 361100009796 Switch II region; other site 361100009797 G4 box; other site 361100009798 G5 box; other site 361100009799 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 361100009800 Translation-initiation factor 2; Region: IF-2; pfam11987 361100009801 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 361100009802 hypothetical protein; Provisional; Region: PRK07714 361100009803 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 361100009804 putative RNA binding cleft [nucleotide binding]; other site 361100009805 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 361100009806 NusA N-terminal domain; Region: NusA_N; pfam08529 361100009807 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 361100009808 RNA binding site [nucleotide binding]; other site 361100009809 homodimer interface [polypeptide binding]; other site 361100009810 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 361100009811 G-X-X-G motif; other site 361100009812 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 361100009813 G-X-X-G motif; other site 361100009814 ribosome maturation protein RimP; Reviewed; Region: PRK00092 361100009815 Sm and related proteins; Region: Sm_like; cl00259 361100009816 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 361100009817 putative oligomer interface [polypeptide binding]; other site 361100009818 putative RNA binding site [nucleotide binding]; other site 361100009819 DNA polymerase III PolC; Validated; Region: polC; PRK00448 361100009820 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 361100009821 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 361100009822 generic binding surface II; other site 361100009823 generic binding surface I; other site 361100009824 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 361100009825 active site 361100009826 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 361100009827 active site 361100009828 catalytic site [active] 361100009829 substrate binding site [chemical binding]; other site 361100009830 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 361100009831 prolyl-tRNA synthetase; Provisional; Region: PRK09194 361100009832 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 361100009833 dimer interface [polypeptide binding]; other site 361100009834 motif 1; other site 361100009835 active site 361100009836 motif 2; other site 361100009837 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 361100009838 putative deacylase active site [active] 361100009839 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 361100009840 active site 361100009841 motif 3; other site 361100009842 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 361100009843 anticodon binding site; other site 361100009844 RIP metalloprotease RseP; Region: TIGR00054 361100009845 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 361100009846 active site 361100009847 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 361100009848 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 361100009849 protein binding site [polypeptide binding]; other site 361100009850 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 361100009851 putative substrate binding region [chemical binding]; other site 361100009852 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 361100009853 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 361100009854 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 361100009855 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 361100009856 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 361100009857 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 361100009858 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 361100009859 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 361100009860 putative FPP binding hydrophobic cleft; other site 361100009861 dimer interface [polypeptide binding]; other site 361100009862 putative IPP diphosphate binding site; other site 361100009863 ribosome recycling factor; Reviewed; Region: frr; PRK00083 361100009864 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 361100009865 hinge region; other site 361100009866 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 361100009867 homohexameric interface [polypeptide binding]; other site 361100009868 uridine monophosphate binding site [chemical binding]; other site 361100009869 putative nucleotide binding site [chemical binding]; other site 361100009870 elongation factor Ts; Provisional; Region: tsf; PRK09377 361100009871 UBA/TS-N domain; Region: UBA; pfam00627 361100009872 Elongation factor TS; Region: EF_TS; pfam00889 361100009873 Elongation factor TS; Region: EF_TS; pfam00889 361100009874 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 361100009875 rRNA interaction site [nucleotide binding]; other site 361100009876 S8 interaction site; other site 361100009877 putative laminin-1 binding site; other site 361100009878 transcriptional repressor CodY; Validated; Region: PRK04158 361100009879 CodY GAF-like domain; Region: CodY; pfam06018 361100009880 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 361100009881 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 361100009882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100009883 Walker A motif; other site 361100009884 ATP binding site [chemical binding]; other site 361100009885 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 361100009886 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 361100009887 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 361100009888 active site 361100009889 HslU subunit interaction site [polypeptide binding]; other site 361100009890 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 361100009891 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 361100009892 active site 361100009893 Int/Topo IB signature motif; other site 361100009894 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 361100009895 Glucose inhibited division protein A; Region: GIDA; pfam01134 361100009896 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 361100009897 DNA topoisomerase; Region: Topoisom_bac; pfam01131 361100009898 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 361100009899 domain I; other site 361100009900 DNA binding groove [nucleotide binding] 361100009901 phosphate binding site [ion binding]; other site 361100009902 domain II; other site 361100009903 domain III; other site 361100009904 nucleotide binding site [chemical binding]; other site 361100009905 catalytic site [active] 361100009906 domain IV; other site 361100009907 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 361100009908 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 361100009909 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 361100009910 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 361100009911 DNA protecting protein DprA; Region: dprA; TIGR00732 361100009912 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 361100009913 CoA binding domain; Region: CoA_binding; smart00881 361100009914 CoA-ligase; Region: Ligase_CoA; pfam00549 361100009915 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 361100009916 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 361100009917 CoA-ligase; Region: Ligase_CoA; pfam00549 361100009918 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 361100009919 RNA/DNA hybrid binding site [nucleotide binding]; other site 361100009920 active site 361100009921 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 361100009922 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 361100009923 GTP/Mg2+ binding site [chemical binding]; other site 361100009924 G4 box; other site 361100009925 G5 box; other site 361100009926 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 361100009927 G1 box; other site 361100009928 G1 box; other site 361100009929 GTP/Mg2+ binding site [chemical binding]; other site 361100009930 Switch I region; other site 361100009931 G2 box; other site 361100009932 G2 box; other site 361100009933 G3 box; other site 361100009934 G3 box; other site 361100009935 Switch II region; other site 361100009936 Switch II region; other site 361100009937 G4 box; other site 361100009938 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 361100009939 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 361100009940 Catalytic site [active] 361100009941 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 361100009942 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 361100009943 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 361100009944 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 361100009945 RimM N-terminal domain; Region: RimM; pfam01782 361100009946 PRC-barrel domain; Region: PRC; pfam05239 361100009947 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 361100009948 KH domain; Region: KH_4; pfam13083 361100009949 G-X-X-G motif; other site 361100009950 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 361100009951 signal recognition particle protein; Provisional; Region: PRK10867 361100009952 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 361100009953 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 361100009954 P loop; other site 361100009955 GTP binding site [chemical binding]; other site 361100009956 Signal peptide binding domain; Region: SRP_SPB; pfam02978 361100009957 putative DNA-binding protein; Validated; Region: PRK00118 361100009958 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 361100009959 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 361100009960 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 361100009961 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 361100009962 P loop; other site 361100009963 GTP binding site [chemical binding]; other site 361100009964 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 361100009965 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 361100009966 Walker A/P-loop; other site 361100009967 ATP binding site [chemical binding]; other site 361100009968 Q-loop/lid; other site 361100009969 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 361100009970 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 361100009971 ABC transporter signature motif; other site 361100009972 Walker B; other site 361100009973 D-loop; other site 361100009974 H-loop/switch region; other site 361100009975 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 361100009976 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 361100009977 dimerization interface [polypeptide binding]; other site 361100009978 active site 361100009979 metal binding site [ion binding]; metal-binding site 361100009980 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 361100009981 dsRNA binding site [nucleotide binding]; other site 361100009982 acyl carrier protein; Provisional; Region: acpP; PRK00982 361100009983 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 361100009984 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 361100009985 NAD(P) binding site [chemical binding]; other site 361100009986 homotetramer interface [polypeptide binding]; other site 361100009987 homodimer interface [polypeptide binding]; other site 361100009988 active site 361100009989 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 361100009990 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 361100009991 putative phosphate acyltransferase; Provisional; Region: PRK05331 361100009992 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 361100009993 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 361100009994 active site 2 [active] 361100009995 active site 1 [active] 361100009996 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 361100009997 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 361100009998 generic binding surface II; other site 361100009999 ssDNA binding site; other site 361100010000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100010001 ATP binding site [chemical binding]; other site 361100010002 putative Mg++ binding site [ion binding]; other site 361100010003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100010004 nucleotide binding region [chemical binding]; other site 361100010005 ATP-binding site [chemical binding]; other site 361100010006 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 361100010007 DAK2 domain; Region: Dak2; pfam02734 361100010008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 361100010009 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 361100010010 Thiamine pyrophosphokinase; Region: TPK; cd07995 361100010011 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 361100010012 active site 361100010013 dimerization interface [polypeptide binding]; other site 361100010014 thiamine binding site [chemical binding]; other site 361100010015 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 361100010016 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 361100010017 substrate binding site [chemical binding]; other site 361100010018 hexamer interface [polypeptide binding]; other site 361100010019 metal binding site [ion binding]; metal-binding site 361100010020 GTPase RsgA; Reviewed; Region: PRK00098 361100010021 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 361100010022 RNA binding site [nucleotide binding]; other site 361100010023 homodimer interface [polypeptide binding]; other site 361100010024 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 361100010025 GTPase/Zn-binding domain interface [polypeptide binding]; other site 361100010026 GTP/Mg2+ binding site [chemical binding]; other site 361100010027 G4 box; other site 361100010028 G5 box; other site 361100010029 G1 box; other site 361100010030 Switch I region; other site 361100010031 G2 box; other site 361100010032 G3 box; other site 361100010033 Switch II region; other site 361100010034 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 361100010035 Catalytic domain of Protein Kinases; Region: PKc; cd00180 361100010036 active site 361100010037 ATP binding site [chemical binding]; other site 361100010038 substrate binding site [chemical binding]; other site 361100010039 activation loop (A-loop); other site 361100010040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 361100010041 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 361100010042 PASTA domain; Region: PASTA; pfam03793 361100010043 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 361100010044 Protein phosphatase 2C; Region: PP2C; pfam00481 361100010045 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 361100010046 active site 361100010047 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 361100010048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100010049 FeS/SAM binding site; other site 361100010050 16S rRNA methyltransferase B; Provisional; Region: PRK14902 361100010051 NusB family; Region: NusB; pfam01029 361100010052 putative RNA binding site [nucleotide binding]; other site 361100010053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100010054 S-adenosylmethionine binding site [chemical binding]; other site 361100010055 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 361100010056 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 361100010057 putative active site [active] 361100010058 substrate binding site [chemical binding]; other site 361100010059 putative cosubstrate binding site; other site 361100010060 catalytic site [active] 361100010061 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 361100010062 substrate binding site [chemical binding]; other site 361100010063 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 361100010064 active site 361100010065 catalytic residues [active] 361100010066 metal binding site [ion binding]; metal-binding site 361100010067 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100010068 primosomal protein N' Region: priA; TIGR00595 361100010069 ATP binding site [chemical binding]; other site 361100010070 putative Mg++ binding site [ion binding]; other site 361100010071 helicase superfamily c-terminal domain; Region: HELICc; smart00490 361100010072 nucleotide binding region [chemical binding]; other site 361100010073 ATP-binding site [chemical binding]; other site 361100010074 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 361100010075 Flavoprotein; Region: Flavoprotein; pfam02441 361100010076 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 361100010077 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 361100010078 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 361100010079 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 361100010080 catalytic site [active] 361100010081 G-X2-G-X-G-K; other site 361100010082 hypothetical protein; Provisional; Region: PRK04323 361100010083 hypothetical protein; Provisional; Region: PRK11820 361100010084 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 361100010085 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 361100010086 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 361100010087 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 361100010088 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 361100010089 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 361100010090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100010091 motif II; other site 361100010092 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 361100010093 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 361100010094 Domain of unknown function (DUF814); Region: DUF814; pfam05670 361100010095 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 361100010096 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 361100010097 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 361100010098 active site 361100010099 DinB family; Region: DinB; cl17821 361100010100 DinB superfamily; Region: DinB_2; pfam12867 361100010101 YoqO-like protein; Region: YoqO; pfam14037 361100010102 YoqO-like protein; Region: YoqO; pfam14037 361100010103 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 361100010104 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 361100010105 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 361100010106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100010107 motif II; other site 361100010108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100010109 active site 361100010110 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 361100010111 active site 361100010112 dimer interface [polypeptide binding]; other site 361100010113 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 361100010114 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 361100010115 heterodimer interface [polypeptide binding]; other site 361100010116 active site 361100010117 FMN binding site [chemical binding]; other site 361100010118 homodimer interface [polypeptide binding]; other site 361100010119 substrate binding site [chemical binding]; other site 361100010120 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 361100010121 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 361100010122 FAD binding pocket [chemical binding]; other site 361100010123 FAD binding motif [chemical binding]; other site 361100010124 phosphate binding motif [ion binding]; other site 361100010125 beta-alpha-beta structure motif; other site 361100010126 NAD binding pocket [chemical binding]; other site 361100010127 Iron coordination center [ion binding]; other site 361100010128 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 361100010129 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 361100010130 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 361100010131 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 361100010132 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 361100010133 ATP-grasp domain; Region: ATP-grasp_4; cl17255 361100010134 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 361100010135 IMP binding site; other site 361100010136 dimer interface [polypeptide binding]; other site 361100010137 interdomain contacts; other site 361100010138 partial ornithine binding site; other site 361100010139 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 361100010140 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 361100010141 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 361100010142 catalytic site [active] 361100010143 subunit interface [polypeptide binding]; other site 361100010144 dihydroorotase; Validated; Region: pyrC; PRK09357 361100010145 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 361100010146 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 361100010147 active site 361100010148 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 361100010149 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 361100010150 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 361100010151 uracil transporter; Provisional; Region: PRK10720 361100010152 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 361100010153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100010154 active site 361100010155 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 361100010156 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100010157 RNA binding surface [nucleotide binding]; other site 361100010158 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 361100010159 active site 361100010160 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 361100010161 lipoprotein signal peptidase; Provisional; Region: PRK14787 361100010162 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 361100010163 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 361100010164 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 361100010165 active site 361100010166 HIGH motif; other site 361100010167 nucleotide binding site [chemical binding]; other site 361100010168 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 361100010169 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 361100010170 active site 361100010171 KMSKS motif; other site 361100010172 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 361100010173 tRNA binding surface [nucleotide binding]; other site 361100010174 anticodon binding site; other site 361100010175 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 361100010176 DivIVA protein; Region: DivIVA; pfam05103 361100010177 DivIVA domain; Region: DivI1A_domain; TIGR03544 361100010178 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 361100010179 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 361100010180 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100010181 RNA binding surface [nucleotide binding]; other site 361100010182 YGGT family; Region: YGGT; pfam02325 361100010183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 361100010184 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 361100010185 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 361100010186 catalytic residue [active] 361100010187 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 361100010188 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 361100010189 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 361100010190 sporulation sigma factor SigG; Reviewed; Region: PRK08215 361100010191 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100010192 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100010193 DNA binding residues [nucleotide binding] 361100010194 sporulation sigma factor SigE; Reviewed; Region: PRK08301 361100010195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100010196 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100010197 DNA binding residues [nucleotide binding] 361100010198 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 361100010199 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 361100010200 cell division protein FtsZ; Validated; Region: PRK09330 361100010201 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 361100010202 nucleotide binding site [chemical binding]; other site 361100010203 SulA interaction site; other site 361100010204 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 361100010205 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 361100010206 nucleotide binding site [chemical binding]; other site 361100010207 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 361100010208 Cell division protein FtsA; Region: FtsA; pfam14450 361100010209 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 361100010210 Cell division protein FtsQ; Region: FtsQ; pfam03799 361100010211 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 361100010212 FAD binding domain; Region: FAD_binding_4; pfam01565 361100010213 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 361100010214 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 361100010215 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 361100010216 active site 361100010217 homodimer interface [polypeptide binding]; other site 361100010218 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 361100010219 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 361100010220 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 361100010221 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 361100010222 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 361100010223 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 361100010224 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 361100010225 Mg++ binding site [ion binding]; other site 361100010226 putative catalytic motif [active] 361100010227 putative substrate binding site [chemical binding]; other site 361100010228 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 361100010229 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 361100010230 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 361100010231 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 361100010232 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 361100010233 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100010234 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100010235 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 361100010236 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 361100010237 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100010238 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100010239 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 361100010240 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 361100010241 Cell division protein FtsL; Region: FtsL; cl11433 361100010242 MraW methylase family; Region: Methyltransf_5; pfam01795 361100010243 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 361100010244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 361100010245 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 361100010246 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 361100010247 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 361100010248 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 361100010249 hypothetical protein; Provisional; Region: PRK13688 361100010250 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 361100010251 Coenzyme A binding pocket [chemical binding]; other site 361100010252 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 361100010253 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 361100010254 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 361100010255 hypothetical protein; Provisional; Region: PRK13670 361100010256 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 361100010257 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 361100010258 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 361100010259 protein binding site [polypeptide binding]; other site 361100010260 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 361100010261 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 361100010262 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 361100010263 active site 361100010264 nucleophile elbow; other site 361100010265 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 361100010266 Nucleoside recognition; Region: Gate; pfam07670 361100010267 Nucleoside recognition; Region: Gate; pfam07670 361100010268 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 361100010269 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 361100010270 active site 361100010271 (T/H)XGH motif; other site 361100010272 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 361100010273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100010274 S-adenosylmethionine binding site [chemical binding]; other site 361100010275 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 361100010276 Protein of unknown function (DUF964); Region: DUF964; pfam06133 361100010277 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 361100010278 catalytic core [active] 361100010279 YlbE-like protein; Region: YlbE; pfam14003 361100010280 Putative coat protein; Region: YlbD_coat; pfam14071 361100010281 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 361100010282 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 361100010283 YugN-like family; Region: YugN; pfam08868 361100010284 formamidase; Provisional; Region: amiF; PRK13287 361100010285 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 361100010286 multimer interface [polypeptide binding]; other site 361100010287 active site 361100010288 catalytic triad [active] 361100010289 dimer interface [polypeptide binding]; other site 361100010290 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 361100010291 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 361100010292 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 361100010293 Subunit I/III interface [polypeptide binding]; other site 361100010294 Subunit III/IV interface [polypeptide binding]; other site 361100010295 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 361100010296 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 361100010297 D-pathway; other site 361100010298 Putative ubiquinol binding site [chemical binding]; other site 361100010299 Low-spin heme (heme b) binding site [chemical binding]; other site 361100010300 Putative water exit pathway; other site 361100010301 Binuclear center (heme o3/CuB) [ion binding]; other site 361100010302 K-pathway; other site 361100010303 Putative proton exit pathway; other site 361100010304 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 361100010305 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 361100010306 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 361100010307 Cytochrome c; Region: Cytochrom_C; pfam00034 361100010308 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 361100010309 UbiA prenyltransferase family; Region: UbiA; pfam01040 361100010310 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 361100010311 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 361100010312 pyruvate carboxylase; Reviewed; Region: PRK12999 361100010313 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 361100010314 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 361100010315 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 361100010316 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 361100010317 active site 361100010318 catalytic residues [active] 361100010319 metal binding site [ion binding]; metal-binding site 361100010320 homodimer binding site [polypeptide binding]; other site 361100010321 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 361100010322 carboxyltransferase (CT) interaction site; other site 361100010323 biotinylation site [posttranslational modification]; other site 361100010324 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 361100010325 hypothetical protein; Provisional; Region: PRK13666 361100010326 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 361100010327 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 361100010328 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 361100010329 putative active site [active] 361100010330 PhoH-like protein; Region: PhoH; pfam02562 361100010331 hypothetical protein; Provisional; Region: PRK06733 361100010332 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 361100010333 YlaH-like protein; Region: YlaH; pfam14036 361100010334 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 361100010335 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 361100010336 G1 box; other site 361100010337 putative GEF interaction site [polypeptide binding]; other site 361100010338 GTP/Mg2+ binding site [chemical binding]; other site 361100010339 Switch I region; other site 361100010340 G2 box; other site 361100010341 G3 box; other site 361100010342 Switch II region; other site 361100010343 G4 box; other site 361100010344 G5 box; other site 361100010345 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 361100010346 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 361100010347 potential frameshift: common BLAST hit: gi|217961444|ref|YP_002340012.1| inositol monophosphatase family protein 361100010348 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 361100010349 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 361100010350 active site 361100010351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 361100010352 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 361100010353 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 361100010354 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 361100010355 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 361100010356 homodimer interface [polypeptide binding]; other site 361100010357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100010358 catalytic residue [active] 361100010359 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 361100010360 transglutaminase; Provisional; Region: tgl; PRK03187 361100010361 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 361100010362 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 361100010363 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 361100010364 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 361100010365 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 361100010366 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 361100010367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100010368 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 361100010369 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 361100010370 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 361100010371 E3 interaction surface; other site 361100010372 lipoyl attachment site [posttranslational modification]; other site 361100010373 e3 binding domain; Region: E3_binding; pfam02817 361100010374 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 361100010375 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 361100010376 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 361100010377 alpha subunit interface [polypeptide binding]; other site 361100010378 TPP binding site [chemical binding]; other site 361100010379 heterodimer interface [polypeptide binding]; other site 361100010380 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 361100010381 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 361100010382 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 361100010383 TPP-binding site [chemical binding]; other site 361100010384 heterodimer interface [polypeptide binding]; other site 361100010385 tetramer interface [polypeptide binding]; other site 361100010386 phosphorylation loop region [posttranslational modification] 361100010387 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 361100010388 active site 361100010389 catalytic residues [active] 361100010390 metal binding site [ion binding]; metal-binding site 361100010391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100010392 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 361100010393 active site 361100010394 motif I; other site 361100010395 motif II; other site 361100010396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100010397 hypothetical protein; Provisional; Region: PRK13667 361100010398 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 361100010399 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100010400 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 361100010401 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 361100010402 TrkA-N domain; Region: TrkA_N; pfam02254 361100010403 TrkA-C domain; Region: TrkA_C; pfam02080 361100010404 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 361100010405 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 361100010406 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 361100010407 metal binding site [ion binding]; metal-binding site 361100010408 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 361100010409 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 361100010410 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 361100010411 trimer interface [polypeptide binding]; other site 361100010412 active site 361100010413 substrate binding site [chemical binding]; other site 361100010414 CoA binding site [chemical binding]; other site 361100010415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100010416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100010417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 361100010418 dimerization interface [polypeptide binding]; other site 361100010419 FOG: CBS domain [General function prediction only]; Region: COG0517 361100010420 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 361100010421 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 361100010422 Protein of unknown function (DUF458); Region: DUF458; pfam04308 361100010423 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 361100010424 catalytic residues [active] 361100010425 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 361100010426 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 361100010427 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 361100010428 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 361100010429 short chain dehydrogenase; Provisional; Region: PRK07677 361100010430 NAD(P) binding site [chemical binding]; other site 361100010431 substrate binding site [chemical binding]; other site 361100010432 homotetramer interface [polypeptide binding]; other site 361100010433 active site 361100010434 homodimer interface [polypeptide binding]; other site 361100010435 phosphodiesterase YaeI; Provisional; Region: PRK11340 361100010436 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 361100010437 putative active site [active] 361100010438 putative metal binding site [ion binding]; other site 361100010439 potential frameshift: common BLAST hit: gi|217961482|ref|YP_002340050.1| polyphosphate kinase 361100010440 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 361100010441 putative active site [active] 361100010442 catalytic site [active] 361100010443 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 361100010444 putative domain interface [polypeptide binding]; other site 361100010445 putative active site [active] 361100010446 catalytic site [active] 361100010447 polyphosphate kinase; Provisional; Region: PRK05443 361100010448 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 361100010449 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 361100010450 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 361100010451 exopolyphosphatase; Region: exo_poly_only; TIGR03706 361100010452 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 361100010453 YkyB-like protein; Region: YkyB; pfam14177 361100010454 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 361100010455 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 361100010456 I-site; other site 361100010457 active site 361100010458 metal binding site [ion binding]; metal-binding site 361100010459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100010460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100010461 putative substrate translocation pore; other site 361100010462 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 361100010463 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 361100010464 DNA binding residues [nucleotide binding] 361100010465 Probable transposase; Region: OrfB_IS605; pfam01385 361100010466 Transcriptional regulator PadR-like family; Region: PadR; cl17335 361100010467 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100010468 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 361100010469 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 361100010470 THF binding site; other site 361100010471 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 361100010472 substrate binding site [chemical binding]; other site 361100010473 THF binding site; other site 361100010474 zinc-binding site [ion binding]; other site 361100010475 Competence protein J (ComJ); Region: ComJ; pfam11033 361100010476 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 361100010477 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 361100010478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100010479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100010480 dimer interface [polypeptide binding]; other site 361100010481 phosphorylation site [posttranslational modification] 361100010482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100010483 ATP binding site [chemical binding]; other site 361100010484 Mg2+ binding site [ion binding]; other site 361100010485 G-X-G motif; other site 361100010486 aminotransferase A; Validated; Region: PRK07683 361100010487 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100010488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100010489 homodimer interface [polypeptide binding]; other site 361100010490 catalytic residue [active] 361100010491 Transcriptional regulators [Transcription]; Region: PurR; COG1609 361100010492 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 361100010493 DNA binding site [nucleotide binding] 361100010494 domain linker motif; other site 361100010495 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 361100010496 putative dimerization interface [polypeptide binding]; other site 361100010497 putative ligand binding site [chemical binding]; other site 361100010498 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 361100010499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100010500 dimer interface [polypeptide binding]; other site 361100010501 conserved gate region; other site 361100010502 putative PBP binding loops; other site 361100010503 ABC-ATPase subunit interface; other site 361100010504 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 361100010505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100010506 dimer interface [polypeptide binding]; other site 361100010507 conserved gate region; other site 361100010508 putative PBP binding loops; other site 361100010509 ABC-ATPase subunit interface; other site 361100010510 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 361100010511 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 361100010512 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 361100010513 homodimer interface [polypeptide binding]; other site 361100010514 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 361100010515 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 361100010516 active site 361100010517 homodimer interface [polypeptide binding]; other site 361100010518 catalytic site [active] 361100010519 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 361100010520 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 361100010521 Ca binding site [ion binding]; other site 361100010522 active site 361100010523 catalytic site [active] 361100010524 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 361100010525 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 361100010526 Walker A/P-loop; other site 361100010527 ATP binding site [chemical binding]; other site 361100010528 Q-loop/lid; other site 361100010529 ABC transporter signature motif; other site 361100010530 Walker B; other site 361100010531 D-loop; other site 361100010532 H-loop/switch region; other site 361100010533 TOBE domain; Region: TOBE_2; pfam08402 361100010534 hypothetical protein; Provisional; Region: PRK06720 361100010535 NAD(P) binding site [chemical binding]; other site 361100010536 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 361100010537 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 361100010538 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 361100010539 Predicted ATPase [General function prediction only]; Region: COG3910 361100010540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100010541 Walker A/P-loop; other site 361100010542 ATP binding site [chemical binding]; other site 361100010543 Q-loop/lid; other site 361100010544 ABC transporter signature motif; other site 361100010545 Walker B; other site 361100010546 D-loop; other site 361100010547 H-loop/switch region; other site 361100010548 putative acyltransferase; Provisional; Region: PRK05790 361100010549 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 361100010550 dimer interface [polypeptide binding]; other site 361100010551 active site 361100010552 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 361100010553 nudix motif; other site 361100010554 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 361100010555 hypothetical protein; Validated; Region: PRK07668 361100010556 hypothetical protein; Validated; Region: PRK07668 361100010557 Predicted transcriptional regulators [Transcription]; Region: COG1695 361100010558 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 361100010559 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 361100010560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100010561 NAD(P) binding site [chemical binding]; other site 361100010562 active site 361100010563 YvrJ protein family; Region: YvrJ; pfam12841 361100010564 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 361100010565 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 361100010566 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 361100010567 Phosphotransferase enzyme family; Region: APH; pfam01636 361100010568 Predicted amidohydrolase [General function prediction only]; Region: COG0388 361100010569 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 361100010570 putative active site [active] 361100010571 catalytic triad [active] 361100010572 putative dimer interface [polypeptide binding]; other site 361100010573 transaminase; Reviewed; Region: PRK08068 361100010574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100010575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100010576 homodimer interface [polypeptide binding]; other site 361100010577 catalytic residue [active] 361100010578 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 361100010579 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 361100010580 dimer interface [polypeptide binding]; other site 361100010581 active site 361100010582 catalytic residue [active] 361100010583 metal binding site [ion binding]; metal-binding site 361100010584 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 361100010585 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 361100010586 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 361100010587 intersubunit interface [polypeptide binding]; other site 361100010588 active site 361100010589 Zn2+ binding site [ion binding]; other site 361100010590 ARD/ARD' family; Region: ARD; pfam03079 361100010591 Cupin domain; Region: Cupin_2; pfam07883 361100010592 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 361100010593 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 361100010594 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 361100010595 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100010596 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100010597 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 361100010598 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 361100010599 metal binding site [ion binding]; metal-binding site 361100010600 active site 361100010601 I-site; other site 361100010602 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 361100010603 dimer interface [polypeptide binding]; other site 361100010604 FMN binding site [chemical binding]; other site 361100010605 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 361100010606 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 361100010607 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 361100010608 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 361100010609 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 361100010610 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 361100010611 dimerization domain swap beta strand [polypeptide binding]; other site 361100010612 regulatory protein interface [polypeptide binding]; other site 361100010613 active site 361100010614 regulatory phosphorylation site [posttranslational modification]; other site 361100010615 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 361100010616 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 361100010617 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 361100010618 active site turn [active] 361100010619 phosphorylation site [posttranslational modification] 361100010620 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 361100010621 HPr interaction site; other site 361100010622 glycerol kinase (GK) interaction site [polypeptide binding]; other site 361100010623 active site 361100010624 phosphorylation site [posttranslational modification] 361100010625 transcriptional antiterminator BglG; Provisional; Region: PRK09772 361100010626 CAT RNA binding domain; Region: CAT_RBD; smart01061 361100010627 PRD domain; Region: PRD; pfam00874 361100010628 PRD domain; Region: PRD; pfam00874 361100010629 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 361100010630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100010631 active site 361100010632 motif I; other site 361100010633 motif II; other site 361100010634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100010635 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 361100010636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100010637 DNA-binding site [nucleotide binding]; DNA binding site 361100010638 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 361100010639 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 361100010640 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 361100010641 active site 361100010642 trimer interface [polypeptide binding]; other site 361100010643 allosteric site; other site 361100010644 active site lid [active] 361100010645 hexamer (dimer of trimers) interface [polypeptide binding]; other site 361100010646 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 361100010647 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 361100010648 active site 361100010649 dimer interface [polypeptide binding]; other site 361100010650 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 361100010651 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100010652 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 361100010653 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 361100010654 Domain of unknown function (DUF309); Region: DUF309; pfam03745 361100010655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100010656 Coenzyme A binding pocket [chemical binding]; other site 361100010657 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 361100010658 active site 361100010659 Predicted secreted protein [Function unknown]; Region: COG4086 361100010660 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 361100010661 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 361100010662 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 361100010663 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 361100010664 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100010665 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 361100010666 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 361100010667 stage V sporulation protein AD; Validated; Region: PRK08304 361100010668 stage V sporulation protein AD; Provisional; Region: PRK12404 361100010669 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 361100010670 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 361100010671 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 361100010672 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 361100010673 Na2 binding site [ion binding]; other site 361100010674 putative substrate binding site 1 [chemical binding]; other site 361100010675 Na binding site 1 [ion binding]; other site 361100010676 putative substrate binding site 2 [chemical binding]; other site 361100010677 sporulation sigma factor SigF; Validated; Region: PRK05572 361100010678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100010679 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 361100010680 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100010681 DNA binding residues [nucleotide binding] 361100010682 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 361100010683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100010684 ATP binding site [chemical binding]; other site 361100010685 Mg2+ binding site [ion binding]; other site 361100010686 G-X-G motif; other site 361100010687 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 361100010688 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 361100010689 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100010690 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 361100010691 Predicted transcriptional regulators [Transcription]; Region: COG1725 361100010692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100010693 DNA-binding site [nucleotide binding]; DNA binding site 361100010694 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100010695 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100010696 Walker A/P-loop; other site 361100010697 ATP binding site [chemical binding]; other site 361100010698 Q-loop/lid; other site 361100010699 ABC transporter signature motif; other site 361100010700 Walker B; other site 361100010701 D-loop; other site 361100010702 H-loop/switch region; other site 361100010703 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 361100010704 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100010705 MarR family; Region: MarR; pfam01047 361100010706 MarR family; Region: MarR_2; cl17246 361100010707 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 361100010708 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 361100010709 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 361100010710 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 361100010711 oligomer interface [polypeptide binding]; other site 361100010712 metal binding site [ion binding]; metal-binding site 361100010713 metal binding site [ion binding]; metal-binding site 361100010714 putative Cl binding site [ion binding]; other site 361100010715 aspartate ring; other site 361100010716 basic sphincter; other site 361100010717 hydrophobic gate; other site 361100010718 periplasmic entrance; other site 361100010719 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 361100010720 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 361100010721 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 361100010722 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 361100010723 purine nucleoside phosphorylase; Provisional; Region: PRK08202 361100010724 phosphopentomutase; Provisional; Region: PRK05362 361100010725 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 361100010726 YtkA-like; Region: YtkA; pfam13115 361100010727 YtkA-like; Region: YtkA; pfam13115 361100010728 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 361100010729 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 361100010730 active site 361100010731 Int/Topo IB signature motif; other site 361100010732 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 361100010733 ferric uptake regulator; Provisional; Region: fur; PRK09462 361100010734 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 361100010735 metal binding site 2 [ion binding]; metal-binding site 361100010736 putative DNA binding helix; other site 361100010737 metal binding site 1 [ion binding]; metal-binding site 361100010738 dimer interface [polypeptide binding]; other site 361100010739 structural Zn2+ binding site [ion binding]; other site 361100010740 stage II sporulation protein M; Region: spo_II_M; TIGR02831 361100010741 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100010742 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100010743 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 361100010744 dimer interface [polypeptide binding]; other site 361100010745 ADP-ribose binding site [chemical binding]; other site 361100010746 active site 361100010747 nudix motif; other site 361100010748 metal binding site [ion binding]; metal-binding site 361100010749 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 361100010750 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 361100010751 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 361100010752 active site 361100010753 catalytic tetrad [active] 361100010754 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 361100010755 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 361100010756 active site 361100010757 catalytic tetrad [active] 361100010758 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 361100010759 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 361100010760 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 361100010761 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 361100010762 putative active site [active] 361100010763 putative metal binding site [ion binding]; other site 361100010764 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 361100010765 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 361100010766 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100010767 Predicted permease [General function prediction only]; Region: COG2056 361100010768 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 361100010769 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 361100010770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 361100010771 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 361100010772 DNA binding site [nucleotide binding] 361100010773 domain linker motif; other site 361100010774 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 361100010775 dimerization interface [polypeptide binding]; other site 361100010776 ligand binding site [chemical binding]; other site 361100010777 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 361100010778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100010779 Coenzyme A binding pocket [chemical binding]; other site 361100010780 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 361100010781 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 361100010782 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 361100010783 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 361100010784 catalytic motif [active] 361100010785 Zn binding site [ion binding]; other site 361100010786 RibD C-terminal domain; Region: RibD_C; cl17279 361100010787 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 361100010788 Lumazine binding domain; Region: Lum_binding; pfam00677 361100010789 Lumazine binding domain; Region: Lum_binding; pfam00677 361100010790 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 361100010791 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 361100010792 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 361100010793 dimerization interface [polypeptide binding]; other site 361100010794 active site 361100010795 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 361100010796 homopentamer interface [polypeptide binding]; other site 361100010797 active site 361100010798 biotin synthase; Validated; Region: PRK06256 361100010799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100010800 FeS/SAM binding site; other site 361100010801 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 361100010802 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 361100010803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100010804 S-adenosylmethionine binding site [chemical binding]; other site 361100010805 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 361100010806 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 361100010807 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 361100010808 substrate-cofactor binding pocket; other site 361100010809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100010810 catalytic residue [active] 361100010811 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 361100010812 AAA domain; Region: AAA_26; pfam13500 361100010813 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 361100010814 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 361100010815 inhibitor-cofactor binding pocket; inhibition site 361100010816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100010817 catalytic residue [active] 361100010818 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 361100010819 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 361100010820 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 361100010821 active site 361100010822 metal binding site [ion binding]; metal-binding site 361100010823 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 361100010824 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 361100010825 active site 361100010826 catalytic triad [active] 361100010827 oxyanion hole [active] 361100010828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100010829 dimerization interface [polypeptide binding]; other site 361100010830 putative DNA binding site [nucleotide binding]; other site 361100010831 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100010832 putative Zn2+ binding site [ion binding]; other site 361100010833 ornithine carbamoyltransferase; Provisional; Region: PRK00779 361100010834 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 361100010835 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 361100010836 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 361100010837 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 361100010838 inhibitor-cofactor binding pocket; inhibition site 361100010839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100010840 catalytic residue [active] 361100010841 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 361100010842 nucleotide binding site [chemical binding]; other site 361100010843 N-acetyl-L-glutamate binding site [chemical binding]; other site 361100010844 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 361100010845 heterotetramer interface [polypeptide binding]; other site 361100010846 active site pocket [active] 361100010847 cleavage site 361100010848 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 361100010849 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 361100010850 YqzH-like protein; Region: YqzH; pfam14164 361100010851 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 361100010852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100010853 NAD(P) binding site [chemical binding]; other site 361100010854 active site 361100010855 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100010856 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 361100010857 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 361100010858 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 361100010859 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 361100010860 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 361100010861 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 361100010862 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 361100010863 putative L-serine binding site [chemical binding]; other site 361100010864 ribonuclease Z; Region: RNase_Z; TIGR02651 361100010865 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 361100010866 DNA polymerase IV; Validated; Region: PRK01810 361100010867 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 361100010868 active site 361100010869 DNA binding site [nucleotide binding] 361100010870 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 361100010871 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 361100010872 peptidase T-like protein; Region: PepT-like; TIGR01883 361100010873 metal binding site [ion binding]; metal-binding site 361100010874 putative dimer interface [polypeptide binding]; other site 361100010875 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100010876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100010877 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 361100010878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 361100010879 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 361100010880 Predicted membrane protein [Function unknown]; Region: COG4129 361100010881 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 361100010882 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 361100010883 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 361100010884 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 361100010885 Walker A/P-loop; other site 361100010886 ATP binding site [chemical binding]; other site 361100010887 Q-loop/lid; other site 361100010888 ABC transporter signature motif; other site 361100010889 Walker B; other site 361100010890 D-loop; other site 361100010891 H-loop/switch region; other site 361100010892 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 361100010893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100010894 dimer interface [polypeptide binding]; other site 361100010895 conserved gate region; other site 361100010896 putative PBP binding loops; other site 361100010897 ABC-ATPase subunit interface; other site 361100010898 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 361100010899 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 361100010900 substrate binding pocket [chemical binding]; other site 361100010901 membrane-bound complex binding site; other site 361100010902 hinge residues; other site 361100010903 Disulphide isomerase; Region: Disulph_isomer; pfam06491 361100010904 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 361100010905 nudix motif; other site 361100010906 Predicted membrane protein [Function unknown]; Region: COG2323 361100010907 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 361100010908 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 361100010909 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 361100010910 E3 interaction surface; other site 361100010911 lipoyl attachment site [posttranslational modification]; other site 361100010912 e3 binding domain; Region: E3_binding; pfam02817 361100010913 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 361100010914 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 361100010915 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 361100010916 alpha subunit interface [polypeptide binding]; other site 361100010917 TPP binding site [chemical binding]; other site 361100010918 heterodimer interface [polypeptide binding]; other site 361100010919 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 361100010920 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 361100010921 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 361100010922 tetramer interface [polypeptide binding]; other site 361100010923 TPP-binding site [chemical binding]; other site 361100010924 heterodimer interface [polypeptide binding]; other site 361100010925 phosphorylation loop region [posttranslational modification] 361100010926 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 361100010927 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 361100010928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100010929 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 361100010930 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 361100010931 nucleotide binding site [chemical binding]; other site 361100010932 Acetokinase family; Region: Acetate_kinase; cl17229 361100010933 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 361100010934 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 361100010935 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 361100010936 NAD binding site [chemical binding]; other site 361100010937 Phe binding site; other site 361100010938 phosphate butyryltransferase; Validated; Region: PRK07742 361100010939 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 361100010940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100010941 putative active site [active] 361100010942 heme pocket [chemical binding]; other site 361100010943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100010944 putative active site [active] 361100010945 heme pocket [chemical binding]; other site 361100010946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100010947 Walker A motif; other site 361100010948 ATP binding site [chemical binding]; other site 361100010949 Walker B motif; other site 361100010950 arginine finger; other site 361100010951 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 361100010952 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 361100010953 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 361100010954 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 361100010955 active site 361100010956 catalytic site [active] 361100010957 metal binding site [ion binding]; metal-binding site 361100010958 dimer interface [polypeptide binding]; other site 361100010959 YycC-like protein; Region: YycC; pfam14174 361100010960 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 361100010961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100010962 active site 361100010963 phosphorylation site [posttranslational modification] 361100010964 intermolecular recognition site; other site 361100010965 dimerization interface [polypeptide binding]; other site 361100010966 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 361100010967 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 361100010968 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 361100010969 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 361100010970 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 361100010971 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 361100010972 Walker A/P-loop; other site 361100010973 ATP binding site [chemical binding]; other site 361100010974 Q-loop/lid; other site 361100010975 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 361100010976 ABC transporter signature motif; other site 361100010977 Walker B; other site 361100010978 D-loop; other site 361100010979 H-loop/switch region; other site 361100010980 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 361100010981 arginine repressor; Provisional; Region: PRK04280 361100010982 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 361100010983 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 361100010984 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 361100010985 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 361100010986 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 361100010987 TPP-binding site; other site 361100010988 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 361100010989 PYR/PP interface [polypeptide binding]; other site 361100010990 dimer interface [polypeptide binding]; other site 361100010991 TPP binding site [chemical binding]; other site 361100010992 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 361100010993 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 361100010994 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 361100010995 substrate binding pocket [chemical binding]; other site 361100010996 chain length determination region; other site 361100010997 substrate-Mg2+ binding site; other site 361100010998 catalytic residues [active] 361100010999 aspartate-rich region 1; other site 361100011000 active site lid residues [active] 361100011001 aspartate-rich region 2; other site 361100011002 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 361100011003 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 361100011004 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 361100011005 generic binding surface II; other site 361100011006 generic binding surface I; other site 361100011007 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 361100011008 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 361100011009 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 361100011010 homodimer interface [polypeptide binding]; other site 361100011011 NADP binding site [chemical binding]; other site 361100011012 substrate binding site [chemical binding]; other site 361100011013 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 361100011014 putative RNA binding site [nucleotide binding]; other site 361100011015 Asp23 family; Region: Asp23; pfam03780 361100011016 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 361100011017 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 361100011018 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 361100011019 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 361100011020 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 361100011021 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 361100011022 carboxyltransferase (CT) interaction site; other site 361100011023 biotinylation site [posttranslational modification]; other site 361100011024 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 361100011025 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 361100011026 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 361100011027 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 361100011028 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 361100011029 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 361100011030 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 361100011031 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 361100011032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100011033 Walker A motif; other site 361100011034 ATP binding site [chemical binding]; other site 361100011035 Walker B motif; other site 361100011036 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 361100011037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100011038 elongation factor P; Validated; Region: PRK00529 361100011039 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 361100011040 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 361100011041 RNA binding site [nucleotide binding]; other site 361100011042 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 361100011043 RNA binding site [nucleotide binding]; other site 361100011044 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 361100011045 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 361100011046 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 361100011047 active site 361100011048 Dehydroquinase class II; Region: DHquinase_II; pfam01220 361100011049 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 361100011050 trimer interface [polypeptide binding]; other site 361100011051 active site 361100011052 dimer interface [polypeptide binding]; other site 361100011053 Conserved membrane protein YqhR; Region: YqhR; pfam11085 361100011054 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 361100011055 manganese transport transcriptional regulator; Provisional; Region: PRK03902 361100011056 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 361100011057 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 361100011058 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 361100011059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100011060 FeS/SAM binding site; other site 361100011061 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 361100011062 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 361100011063 active site residue [active] 361100011064 Transcriptional regulators [Transcription]; Region: PurR; COG1609 361100011065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 361100011066 DNA binding site [nucleotide binding] 361100011067 domain linker motif; other site 361100011068 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 361100011069 putative dimerization interface [polypeptide binding]; other site 361100011070 putative ligand binding site [chemical binding]; other site 361100011071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100011072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100011073 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 361100011074 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 361100011075 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 361100011076 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 361100011077 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 361100011078 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 361100011079 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 361100011080 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100011081 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100011082 Walker A/P-loop; other site 361100011083 ATP binding site [chemical binding]; other site 361100011084 Q-loop/lid; other site 361100011085 ABC transporter signature motif; other site 361100011086 Walker B; other site 361100011087 D-loop; other site 361100011088 H-loop/switch region; other site 361100011089 Predicted transcriptional regulators [Transcription]; Region: COG1725 361100011090 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100011091 DNA-binding site [nucleotide binding]; DNA binding site 361100011092 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 361100011093 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 361100011094 tetramer interface [polypeptide binding]; other site 361100011095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100011096 catalytic residue [active] 361100011097 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 361100011098 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 361100011099 tetramer interface [polypeptide binding]; other site 361100011100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100011101 catalytic residue [active] 361100011102 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 361100011103 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 361100011104 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 361100011105 DEAD-like helicases superfamily; Region: DEXDc; smart00487 361100011106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100011107 ATP binding site [chemical binding]; other site 361100011108 putative Mg++ binding site [ion binding]; other site 361100011109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100011110 nucleotide binding region [chemical binding]; other site 361100011111 ATP-binding site [chemical binding]; other site 361100011112 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 361100011113 YqzE-like protein; Region: YqzE; pfam14038 361100011114 shikimate kinase; Reviewed; Region: aroK; PRK00131 361100011115 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 361100011116 ADP binding site [chemical binding]; other site 361100011117 magnesium binding site [ion binding]; other site 361100011118 putative shikimate binding site; other site 361100011119 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 361100011120 ComG operon protein 7; Region: ComGG; pfam14173 361100011121 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 361100011122 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 361100011123 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 361100011124 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 361100011125 Type II/IV secretion system protein; Region: T2SE; pfam00437 361100011126 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 361100011127 Walker A motif; other site 361100011128 ATP binding site [chemical binding]; other site 361100011129 Walker B motif; other site 361100011130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100011131 putative DNA binding site [nucleotide binding]; other site 361100011132 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 361100011133 putative Zn2+ binding site [ion binding]; other site 361100011134 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 361100011135 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 361100011136 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 361100011137 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 361100011138 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 361100011139 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 361100011140 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 361100011141 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 361100011142 active site 361100011143 homodimer interface [polypeptide binding]; other site 361100011144 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 361100011145 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 361100011146 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 361100011147 substrate binding pocket [chemical binding]; other site 361100011148 dimer interface [polypeptide binding]; other site 361100011149 inhibitor binding site; inhibition site 361100011150 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 361100011151 B12 binding site [chemical binding]; other site 361100011152 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 361100011153 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 361100011154 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 361100011155 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 361100011156 FAD binding site [chemical binding]; other site 361100011157 cystathionine gamma-synthase; Reviewed; Region: PRK08247 361100011158 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 361100011159 homodimer interface [polypeptide binding]; other site 361100011160 substrate-cofactor binding pocket; other site 361100011161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100011162 catalytic residue [active] 361100011163 cystathionine beta-lyase; Provisional; Region: PRK08064 361100011164 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 361100011165 homodimer interface [polypeptide binding]; other site 361100011166 substrate-cofactor binding pocket; other site 361100011167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100011168 catalytic residue [active] 361100011169 Isochorismatase family; Region: Isochorismatase; pfam00857 361100011170 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 361100011171 catalytic triad [active] 361100011172 conserved cis-peptide bond; other site 361100011173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100011174 dimerization interface [polypeptide binding]; other site 361100011175 putative DNA binding site [nucleotide binding]; other site 361100011176 putative Zn2+ binding site [ion binding]; other site 361100011177 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 361100011178 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 361100011179 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 361100011180 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 361100011181 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 361100011182 nucleotide binding site [chemical binding]; other site 361100011183 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 361100011184 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 361100011185 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 361100011186 potential frameshift: common BLAST hit: gi|217961758|ref|YP_002340328.1| nucleotidyl transferase family protein 361100011187 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 361100011188 active site 361100011189 metal binding site [ion binding]; metal-binding site 361100011190 substrate binding site [chemical binding]; other site 361100011191 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 361100011192 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 361100011193 active site 361100011194 Substrate binding site; other site 361100011195 Mg++ binding site; other site 361100011196 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 361100011197 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 361100011198 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 361100011199 PhoU domain; Region: PhoU; pfam01895 361100011200 PhoU domain; Region: PhoU; pfam01895 361100011201 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 361100011202 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 361100011203 Walker A/P-loop; other site 361100011204 ATP binding site [chemical binding]; other site 361100011205 Q-loop/lid; other site 361100011206 ABC transporter signature motif; other site 361100011207 Walker B; other site 361100011208 D-loop; other site 361100011209 H-loop/switch region; other site 361100011210 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 361100011211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100011212 dimer interface [polypeptide binding]; other site 361100011213 conserved gate region; other site 361100011214 putative PBP binding loops; other site 361100011215 ABC-ATPase subunit interface; other site 361100011216 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 361100011217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100011218 dimer interface [polypeptide binding]; other site 361100011219 conserved gate region; other site 361100011220 putative PBP binding loops; other site 361100011221 ABC-ATPase subunit interface; other site 361100011222 PBP superfamily domain; Region: PBP_like_2; cl17296 361100011223 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 361100011224 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100011225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100011226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100011227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100011228 putative substrate translocation pore; other site 361100011229 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 361100011230 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 361100011231 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 361100011232 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 361100011233 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 361100011234 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 361100011235 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 361100011236 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 361100011237 metal binding site 2 [ion binding]; metal-binding site 361100011238 putative DNA binding helix; other site 361100011239 metal binding site 1 [ion binding]; metal-binding site 361100011240 dimer interface [polypeptide binding]; other site 361100011241 structural Zn2+ binding site [ion binding]; other site 361100011242 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 361100011243 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100011244 ABC-ATPase subunit interface; other site 361100011245 dimer interface [polypeptide binding]; other site 361100011246 putative PBP binding regions; other site 361100011247 potential frameshift: common BLAST hit: gi|217961772|ref|YP_002340342.1| cation ABC transporter, ATP-binding protein 361100011248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100011249 ABC transporter signature motif; other site 361100011250 Walker B; other site 361100011251 D-loop; other site 361100011252 H-loop/switch region; other site 361100011253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100011254 Walker A/P-loop; other site 361100011255 ATP binding site [chemical binding]; other site 361100011256 Q-loop/lid; other site 361100011257 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100011258 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100011259 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100011260 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 361100011261 endonuclease IV; Provisional; Region: PRK01060 361100011262 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 361100011263 AP (apurinic/apyrimidinic) site pocket; other site 361100011264 DNA interaction; other site 361100011265 Metal-binding active site; metal-binding site 361100011266 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 361100011267 DEAD-like helicases superfamily; Region: DEXDc; smart00487 361100011268 ATP binding site [chemical binding]; other site 361100011269 Mg++ binding site [ion binding]; other site 361100011270 motif III; other site 361100011271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100011272 nucleotide binding region [chemical binding]; other site 361100011273 ATP-binding site [chemical binding]; other site 361100011274 YqfQ-like protein; Region: YqfQ; pfam14181 361100011275 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 361100011276 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 361100011277 Uncharacterized conserved protein [Function unknown]; Region: COG0327 361100011278 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 361100011279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 361100011280 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 361100011281 Uncharacterized conserved protein [Function unknown]; Region: COG0327 361100011282 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 361100011283 Family of unknown function (DUF633); Region: DUF633; pfam04816 361100011284 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 361100011285 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 361100011286 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 361100011287 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 361100011288 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 361100011289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100011290 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 361100011291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100011292 DNA binding residues [nucleotide binding] 361100011293 DNA primase; Validated; Region: dnaG; PRK05667 361100011294 CHC2 zinc finger; Region: zf-CHC2; pfam01807 361100011295 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 361100011296 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 361100011297 active site 361100011298 metal binding site [ion binding]; metal-binding site 361100011299 interdomain interaction site; other site 361100011300 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 361100011301 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 361100011302 PEP synthetase regulatory protein; Provisional; Region: PRK05339 361100011303 HTH domain; Region: HTH_11; pfam08279 361100011304 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 361100011305 FOG: CBS domain [General function prediction only]; Region: COG0517 361100011306 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 361100011307 Recombination protein O N terminal; Region: RecO_N; pfam11967 361100011308 Recombination protein O C terminal; Region: RecO_C; pfam02565 361100011309 YqzL-like protein; Region: YqzL; pfam14006 361100011310 GTPase Era; Reviewed; Region: era; PRK00089 361100011311 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 361100011312 G1 box; other site 361100011313 GTP/Mg2+ binding site [chemical binding]; other site 361100011314 Switch I region; other site 361100011315 G2 box; other site 361100011316 Switch II region; other site 361100011317 G3 box; other site 361100011318 G4 box; other site 361100011319 G5 box; other site 361100011320 KH domain; Region: KH_2; pfam07650 361100011321 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 361100011322 active site 361100011323 catalytic motif [active] 361100011324 Zn binding site [ion binding]; other site 361100011325 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 361100011326 metal-binding heat shock protein; Provisional; Region: PRK00016 361100011327 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 361100011328 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 361100011329 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100011330 Zn2+ binding site [ion binding]; other site 361100011331 Mg2+ binding site [ion binding]; other site 361100011332 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 361100011333 PhoH-like protein; Region: PhoH; pfam02562 361100011334 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 361100011335 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 361100011336 Yqey-like protein; Region: YqeY; pfam09424 361100011337 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 361100011338 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 361100011339 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 361100011340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100011341 FeS/SAM binding site; other site 361100011342 TRAM domain; Region: TRAM; cl01282 361100011343 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 361100011344 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 361100011345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100011346 S-adenosylmethionine binding site [chemical binding]; other site 361100011347 chaperone protein DnaJ; Provisional; Region: PRK14280 361100011348 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 361100011349 HSP70 interaction site [polypeptide binding]; other site 361100011350 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 361100011351 substrate binding site [polypeptide binding]; other site 361100011352 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 361100011353 Zn binding sites [ion binding]; other site 361100011354 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 361100011355 dimer interface [polypeptide binding]; other site 361100011356 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 361100011357 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 361100011358 nucleotide binding site [chemical binding]; other site 361100011359 NEF interaction site [polypeptide binding]; other site 361100011360 SBD interface [polypeptide binding]; other site 361100011361 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 361100011362 GrpE; Region: GrpE; pfam01025 361100011363 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 361100011364 dimer interface [polypeptide binding]; other site 361100011365 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 361100011366 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 361100011367 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 361100011368 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 361100011369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100011370 FeS/SAM binding site; other site 361100011371 HemN C-terminal domain; Region: HemN_C; pfam06969 361100011372 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100011373 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 361100011374 GTP-binding protein LepA; Provisional; Region: PRK05433 361100011375 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 361100011376 G1 box; other site 361100011377 putative GEF interaction site [polypeptide binding]; other site 361100011378 GTP/Mg2+ binding site [chemical binding]; other site 361100011379 Switch I region; other site 361100011380 G2 box; other site 361100011381 G3 box; other site 361100011382 Switch II region; other site 361100011383 G4 box; other site 361100011384 G5 box; other site 361100011385 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 361100011386 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 361100011387 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 361100011388 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 361100011389 germination protease; Provisional; Region: PRK02858 361100011390 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 361100011391 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 361100011392 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 361100011393 YqzM-like protein; Region: YqzM; pfam14141 361100011394 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 361100011395 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 361100011396 Competence protein; Region: Competence; pfam03772 361100011397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100011398 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 361100011399 catalytic motif [active] 361100011400 Zn binding site [ion binding]; other site 361100011401 SLBB domain; Region: SLBB; pfam10531 361100011402 comEA protein; Region: comE; TIGR01259 361100011403 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 361100011404 late competence protein ComER; Validated; Region: PRK07680 361100011405 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 361100011406 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 361100011407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100011408 S-adenosylmethionine binding site [chemical binding]; other site 361100011409 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 361100011410 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100011411 Zn2+ binding site [ion binding]; other site 361100011412 Mg2+ binding site [ion binding]; other site 361100011413 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 361100011414 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 361100011415 active site 361100011416 (T/H)XGH motif; other site 361100011417 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 361100011418 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 361100011419 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 361100011420 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 361100011421 shikimate binding site; other site 361100011422 NAD(P) binding site [chemical binding]; other site 361100011423 GTPase YqeH; Provisional; Region: PRK13796 361100011424 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 361100011425 GTP/Mg2+ binding site [chemical binding]; other site 361100011426 G4 box; other site 361100011427 G5 box; other site 361100011428 G1 box; other site 361100011429 Switch I region; other site 361100011430 G2 box; other site 361100011431 G3 box; other site 361100011432 Switch II region; other site 361100011433 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 361100011434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100011435 active site 361100011436 motif I; other site 361100011437 motif II; other site 361100011438 Sporulation inhibitor A; Region: Sda; pfam08970 361100011439 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 361100011440 sporulation sigma factor SigK; Reviewed; Region: PRK05803 361100011441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100011442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100011443 DNA binding residues [nucleotide binding] 361100011444 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 361100011445 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 361100011446 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 361100011447 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 361100011448 synthetase active site [active] 361100011449 NTP binding site [chemical binding]; other site 361100011450 metal binding site [ion binding]; metal-binding site 361100011451 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 361100011452 dimer interface [polypeptide binding]; other site 361100011453 Alkaline phosphatase homologues; Region: alkPPc; smart00098 361100011454 active site 361100011455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100011456 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 361100011457 Coenzyme A binding pocket [chemical binding]; other site 361100011458 PGAP1-like protein; Region: PGAP1; pfam07819 361100011459 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100011460 DoxX; Region: DoxX; cl17842 361100011461 CHAT domain; Region: CHAT; cl17868 361100011462 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 361100011463 catalytic core [active] 361100011464 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 361100011465 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 361100011466 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 361100011467 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 361100011468 putative active site [active] 361100011469 catalytic triad [active] 361100011470 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 361100011471 putative integrin binding motif; other site 361100011472 PA/protease domain interface [polypeptide binding]; other site 361100011473 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 361100011474 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 361100011475 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 361100011476 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 361100011477 cofactor binding site; other site 361100011478 metal binding site [ion binding]; metal-binding site 361100011479 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 361100011480 aromatic arch; other site 361100011481 DCoH dimer interaction site [polypeptide binding]; other site 361100011482 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 361100011483 DCoH tetramer interaction site [polypeptide binding]; other site 361100011484 substrate binding site [chemical binding]; other site 361100011485 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 361100011486 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 361100011487 putative metal binding site [ion binding]; other site 361100011488 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 361100011489 active site 361100011490 metal binding site [ion binding]; metal-binding site 361100011491 Predicted membrane protein [Function unknown]; Region: COG2259 361100011492 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 361100011493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100011494 non-specific DNA binding site [nucleotide binding]; other site 361100011495 salt bridge; other site 361100011496 sequence-specific DNA binding site [nucleotide binding]; other site 361100011497 Cupin domain; Region: Cupin_2; pfam07883 361100011498 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 361100011499 active site 2 [active] 361100011500 active site 1 [active] 361100011501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100011502 Coenzyme A binding pocket [chemical binding]; other site 361100011503 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100011504 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100011505 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 361100011506 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 361100011507 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 361100011508 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 361100011509 Walker A/P-loop; other site 361100011510 ATP binding site [chemical binding]; other site 361100011511 Q-loop/lid; other site 361100011512 ABC transporter signature motif; other site 361100011513 Walker B; other site 361100011514 D-loop; other site 361100011515 H-loop/switch region; other site 361100011516 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 361100011517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100011518 ABC-ATPase subunit interface; other site 361100011519 dimer interface [polypeptide binding]; other site 361100011520 putative PBP binding regions; other site 361100011521 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 361100011522 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 361100011523 intersubunit interface [polypeptide binding]; other site 361100011524 YrhC-like protein; Region: YrhC; pfam14143 361100011525 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 361100011526 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 361100011527 putative catalytic cysteine [active] 361100011528 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 361100011529 putative active site [active] 361100011530 metal binding site [ion binding]; metal-binding site 361100011531 cystathionine beta-lyase; Provisional; Region: PRK07671 361100011532 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 361100011533 homodimer interface [polypeptide binding]; other site 361100011534 substrate-cofactor binding pocket; other site 361100011535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100011536 catalytic residue [active] 361100011537 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 361100011538 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 361100011539 dimer interface [polypeptide binding]; other site 361100011540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100011541 catalytic residue [active] 361100011542 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 361100011543 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 361100011544 Methyltransferase domain; Region: Methyltransf_23; pfam13489 361100011545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100011546 S-adenosylmethionine binding site [chemical binding]; other site 361100011547 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 361100011548 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 361100011549 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 361100011550 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 361100011551 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100011552 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 361100011553 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 361100011554 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 361100011555 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 361100011556 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 361100011557 ATP-binding site [chemical binding]; other site 361100011558 Sugar specificity; other site 361100011559 Pyrimidine base specificity; other site 361100011560 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 361100011561 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 361100011562 Peptidase family U32; Region: Peptidase_U32; pfam01136 361100011563 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 361100011564 Peptidase family U32; Region: Peptidase_U32; pfam01136 361100011565 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 361100011566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100011567 S-adenosylmethionine binding site [chemical binding]; other site 361100011568 YceG-like family; Region: YceG; pfam02618 361100011569 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 361100011570 dimerization interface [polypeptide binding]; other site 361100011571 hypothetical protein; Provisional; Region: PRK13678 361100011572 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 361100011573 hypothetical protein; Provisional; Region: PRK05473 361100011574 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 361100011575 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 361100011576 motif 1; other site 361100011577 active site 361100011578 motif 2; other site 361100011579 motif 3; other site 361100011580 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 361100011581 DHHA1 domain; Region: DHHA1; pfam02272 361100011582 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 361100011583 Domain of unknown function DUF20; Region: UPF0118; pfam01594 361100011584 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 361100011585 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 361100011586 AAA domain; Region: AAA_30; pfam13604 361100011587 Family description; Region: UvrD_C_2; pfam13538 361100011588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100011589 TPR motif; other site 361100011590 TPR repeat; Region: TPR_11; pfam13414 361100011591 binding surface 361100011592 TPR repeat; Region: TPR_11; pfam13414 361100011593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100011594 binding surface 361100011595 TPR motif; other site 361100011596 TPR repeat; Region: TPR_11; pfam13414 361100011597 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 361100011598 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 361100011599 Ligand Binding Site [chemical binding]; other site 361100011600 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 361100011601 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 361100011602 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100011603 catalytic residue [active] 361100011604 Predicted transcriptional regulator [Transcription]; Region: COG1959 361100011605 Transcriptional regulator; Region: Rrf2; pfam02082 361100011606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100011607 Walker A motif; other site 361100011608 ATP binding site [chemical binding]; other site 361100011609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 361100011610 Walker B motif; other site 361100011611 recombination factor protein RarA; Provisional; Region: PRK14700 361100011612 arginine finger; other site 361100011613 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 361100011614 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 361100011615 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 361100011616 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 361100011617 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 361100011618 putative ATP binding site [chemical binding]; other site 361100011619 putative substrate interface [chemical binding]; other site 361100011620 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 361100011621 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 361100011622 dimer interface [polypeptide binding]; other site 361100011623 anticodon binding site; other site 361100011624 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 361100011625 homodimer interface [polypeptide binding]; other site 361100011626 motif 1; other site 361100011627 active site 361100011628 motif 2; other site 361100011629 GAD domain; Region: GAD; pfam02938 361100011630 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 361100011631 motif 3; other site 361100011632 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 361100011633 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 361100011634 dimer interface [polypeptide binding]; other site 361100011635 motif 1; other site 361100011636 active site 361100011637 motif 2; other site 361100011638 motif 3; other site 361100011639 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 361100011640 anticodon binding site; other site 361100011641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100011642 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 361100011643 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 361100011644 putative active site [active] 361100011645 dimerization interface [polypeptide binding]; other site 361100011646 putative tRNAtyr binding site [nucleotide binding]; other site 361100011647 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 361100011648 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100011649 Zn2+ binding site [ion binding]; other site 361100011650 Mg2+ binding site [ion binding]; other site 361100011651 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 361100011652 synthetase active site [active] 361100011653 NTP binding site [chemical binding]; other site 361100011654 metal binding site [ion binding]; metal-binding site 361100011655 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 361100011656 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 361100011657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100011658 active site 361100011659 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 361100011660 DHH family; Region: DHH; pfam01368 361100011661 DHHA1 domain; Region: DHHA1; pfam02272 361100011662 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 361100011663 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 361100011664 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 361100011665 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 361100011666 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 361100011667 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 361100011668 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 361100011669 Protein export membrane protein; Region: SecD_SecF; pfam02355 361100011670 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 361100011671 stage V sporulation protein B; Region: spore_V_B; TIGR02900 361100011672 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 361100011673 Predicted membrane protein [Function unknown]; Region: COG2323 361100011674 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 361100011675 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 361100011676 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 361100011677 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 361100011678 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 361100011679 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 361100011680 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 361100011681 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 361100011682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100011683 Walker A motif; other site 361100011684 ATP binding site [chemical binding]; other site 361100011685 Walker B motif; other site 361100011686 arginine finger; other site 361100011687 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 361100011688 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 361100011689 RuvA N terminal domain; Region: RuvA_N; pfam01330 361100011690 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 361100011691 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 361100011692 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 361100011693 putative ligand binding residues [chemical binding]; other site 361100011694 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 361100011695 BofC C-terminal domain; Region: BofC_C; pfam08955 361100011696 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100011697 EamA-like transporter family; Region: EamA; pfam00892 361100011698 EamA-like transporter family; Region: EamA; pfam00892 361100011699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100011700 dimerization interface [polypeptide binding]; other site 361100011701 putative DNA binding site [nucleotide binding]; other site 361100011702 putative Zn2+ binding site [ion binding]; other site 361100011703 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 361100011704 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 361100011705 quinolinate synthetase; Provisional; Region: PRK09375 361100011706 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 361100011707 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 361100011708 dimerization interface [polypeptide binding]; other site 361100011709 active site 361100011710 L-aspartate oxidase; Provisional; Region: PRK08071 361100011711 L-aspartate oxidase; Provisional; Region: PRK06175 361100011712 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 361100011713 cysteine desulfurase; Provisional; Region: PRK02948 361100011714 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 361100011715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100011716 catalytic residue [active] 361100011717 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 361100011718 HTH domain; Region: HTH_11; pfam08279 361100011719 3H domain; Region: 3H; pfam02829 361100011720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 361100011721 MOSC domain; Region: MOSC; pfam03473 361100011722 3-alpha domain; Region: 3-alpha; pfam03475 361100011723 prephenate dehydratase; Provisional; Region: PRK11898 361100011724 Prephenate dehydratase; Region: PDT; pfam00800 361100011725 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 361100011726 putative L-Phe binding site [chemical binding]; other site 361100011727 FtsX-like permease family; Region: FtsX; pfam02687 361100011728 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100011729 FtsX-like permease family; Region: FtsX; pfam02687 361100011730 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100011731 FtsX-like permease family; Region: FtsX; pfam02687 361100011732 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100011733 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100011734 Walker A/P-loop; other site 361100011735 ATP binding site [chemical binding]; other site 361100011736 Q-loop/lid; other site 361100011737 ABC transporter signature motif; other site 361100011738 Walker B; other site 361100011739 D-loop; other site 361100011740 H-loop/switch region; other site 361100011741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100011742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 361100011743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100011744 ATP binding site [chemical binding]; other site 361100011745 Mg2+ binding site [ion binding]; other site 361100011746 G-X-G motif; other site 361100011747 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100011748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100011749 active site 361100011750 phosphorylation site [posttranslational modification] 361100011751 intermolecular recognition site; other site 361100011752 dimerization interface [polypeptide binding]; other site 361100011753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100011754 DNA binding site [nucleotide binding] 361100011755 GTPase CgtA; Reviewed; Region: obgE; PRK12297 361100011756 GTP1/OBG; Region: GTP1_OBG; pfam01018 361100011757 Obg GTPase; Region: Obg; cd01898 361100011758 G1 box; other site 361100011759 GTP/Mg2+ binding site [chemical binding]; other site 361100011760 Switch I region; other site 361100011761 G2 box; other site 361100011762 G3 box; other site 361100011763 Switch II region; other site 361100011764 G4 box; other site 361100011765 G5 box; other site 361100011766 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 361100011767 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 361100011768 hypothetical protein; Provisional; Region: PRK14553 361100011769 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 361100011770 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 361100011771 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 361100011772 homodimer interface [polypeptide binding]; other site 361100011773 oligonucleotide binding site [chemical binding]; other site 361100011774 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 361100011775 Peptidase family M50; Region: Peptidase_M50; pfam02163 361100011776 active site 361100011777 putative substrate binding region [chemical binding]; other site 361100011778 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 361100011779 Peptidase family M23; Region: Peptidase_M23; pfam01551 361100011780 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 361100011781 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 361100011782 Switch I; other site 361100011783 Switch II; other site 361100011784 septum formation inhibitor; Reviewed; Region: minC; PRK00513 361100011785 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 361100011786 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 361100011787 rod shape-determining protein MreC; Provisional; Region: PRK13922 361100011788 rod shape-determining protein MreC; Region: MreC; pfam04085 361100011789 rod shape-determining protein MreB; Provisional; Region: PRK13927 361100011790 MreB and similar proteins; Region: MreB_like; cd10225 361100011791 nucleotide binding site [chemical binding]; other site 361100011792 Mg binding site [ion binding]; other site 361100011793 putative protofilament interaction site [polypeptide binding]; other site 361100011794 RodZ interaction site [polypeptide binding]; other site 361100011795 hypothetical protein; Reviewed; Region: PRK00024 361100011796 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 361100011797 MPN+ (JAMM) motif; other site 361100011798 Zinc-binding site [ion binding]; other site 361100011799 Maf-like protein; Region: Maf; pfam02545 361100011800 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 361100011801 active site 361100011802 dimer interface [polypeptide binding]; other site 361100011803 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 361100011804 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 361100011805 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 361100011806 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 361100011807 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 361100011808 active site 361100011809 HIGH motif; other site 361100011810 nucleotide binding site [chemical binding]; other site 361100011811 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 361100011812 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 361100011813 active site 361100011814 KMSKS motif; other site 361100011815 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 361100011816 tRNA binding surface [nucleotide binding]; other site 361100011817 anticodon binding site; other site 361100011818 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 361100011819 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 361100011820 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 361100011821 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 361100011822 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 361100011823 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 361100011824 inhibitor-cofactor binding pocket; inhibition site 361100011825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100011826 catalytic residue [active] 361100011827 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 361100011828 dimer interface [polypeptide binding]; other site 361100011829 active site 361100011830 Schiff base residues; other site 361100011831 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 361100011832 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 361100011833 active site 361100011834 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 361100011835 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 361100011836 domain interfaces; other site 361100011837 active site 361100011838 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 361100011839 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 361100011840 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 361100011841 tRNA; other site 361100011842 putative tRNA binding site [nucleotide binding]; other site 361100011843 putative NADP binding site [chemical binding]; other site 361100011844 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 361100011845 Transcriptional regulators [Transcription]; Region: MarR; COG1846 361100011846 MarR family; Region: MarR; pfam01047 361100011847 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 361100011848 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 361100011849 G1 box; other site 361100011850 GTP/Mg2+ binding site [chemical binding]; other site 361100011851 Switch I region; other site 361100011852 G2 box; other site 361100011853 G3 box; other site 361100011854 Switch II region; other site 361100011855 G4 box; other site 361100011856 G5 box; other site 361100011857 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 361100011858 Found in ATP-dependent protease La (LON); Region: LON; smart00464 361100011859 Found in ATP-dependent protease La (LON); Region: LON; smart00464 361100011860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100011861 Walker A motif; other site 361100011862 ATP binding site [chemical binding]; other site 361100011863 Walker B motif; other site 361100011864 arginine finger; other site 361100011865 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 361100011866 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 361100011867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100011868 Walker A motif; other site 361100011869 ATP binding site [chemical binding]; other site 361100011870 Walker B motif; other site 361100011871 arginine finger; other site 361100011872 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 361100011873 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 361100011874 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 361100011875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100011876 Walker A motif; other site 361100011877 ATP binding site [chemical binding]; other site 361100011878 Walker B motif; other site 361100011879 arginine finger; other site 361100011880 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 361100011881 trigger factor; Provisional; Region: tig; PRK01490 361100011882 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 361100011883 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 361100011884 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 361100011885 pentamer interface [polypeptide binding]; other site 361100011886 dodecaamer interface [polypeptide binding]; other site 361100011887 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 361100011888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100011889 non-specific DNA binding site [nucleotide binding]; other site 361100011890 salt bridge; other site 361100011891 sequence-specific DNA binding site [nucleotide binding]; other site 361100011892 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 361100011893 Helix-turn-helix domain; Region: HTH_36; pfam13730 361100011894 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100011895 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 361100011896 catalytic residues [active] 361100011897 catalytic nucleophile [active] 361100011898 Presynaptic Site I dimer interface [polypeptide binding]; other site 361100011899 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 361100011900 Synaptic Flat tetramer interface [polypeptide binding]; other site 361100011901 Synaptic Site I dimer interface [polypeptide binding]; other site 361100011902 DNA binding site [nucleotide binding] 361100011903 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 361100011904 trimer interface [polypeptide binding]; other site 361100011905 active site 361100011906 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 361100011907 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 361100011908 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 361100011909 active site 361100011910 catalytic residues [active] 361100011911 DNA binding site [nucleotide binding] 361100011912 Int/Topo IB signature motif; other site 361100011913 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 361100011914 active site 361100011915 metal binding site [ion binding]; metal-binding site 361100011916 homotetramer interface [polypeptide binding]; other site 361100011917 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 361100011918 active site 361100011919 dimerization interface [polypeptide binding]; other site 361100011920 ribonuclease PH; Reviewed; Region: rph; PRK00173 361100011921 Ribonuclease PH; Region: RNase_PH_bact; cd11362 361100011922 hexamer interface [polypeptide binding]; other site 361100011923 active site 361100011924 Sporulation and spore germination; Region: Germane; pfam10646 361100011925 Spore germination protein [General function prediction only]; Region: COG5401 361100011926 Sporulation and spore germination; Region: Germane; pfam10646 361100011927 glutamate racemase; Provisional; Region: PRK00865 361100011928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100011929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100011930 putative substrate translocation pore; other site 361100011931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100011932 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 361100011933 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 361100011934 potential catalytic triad [active] 361100011935 conserved cys residue [active] 361100011936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100011937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100011938 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 361100011939 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 361100011940 potential catalytic triad [active] 361100011941 conserved cys residue [active] 361100011942 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100011943 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 361100011944 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100011945 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 361100011946 catalytic residues [active] 361100011947 catalytic nucleophile [active] 361100011948 Recombinase; Region: Recombinase; pfam07508 361100011949 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 361100011950 AAA domain; Region: AAA_21; pfam13304 361100011951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100011952 ABC transporter signature motif; other site 361100011953 Walker B; other site 361100011954 D-loop; other site 361100011955 H-loop/switch region; other site 361100011956 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100011957 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 361100011958 catalytic residues [active] 361100011959 catalytic nucleophile [active] 361100011960 Recombinase; Region: Recombinase; pfam07508 361100011961 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100011962 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 361100011963 catalytic residues [active] 361100011964 catalytic nucleophile [active] 361100011965 Recombinase; Region: Recombinase; pfam07508 361100011966 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 361100011967 DHH family; Region: DHH; pfam01368 361100011968 DHHA1 domain; Region: DHHA1; pfam02272 361100011969 Helix-turn-helix domain; Region: HTH_17; pfam12728 361100011970 putative uracil/xanthine transporter; Provisional; Region: PRK11412 361100011971 putative deaminase; Validated; Region: PRK06846 361100011972 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 361100011973 active site 361100011974 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 361100011975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100011976 non-specific DNA binding site [nucleotide binding]; other site 361100011977 salt bridge; other site 361100011978 sequence-specific DNA binding site [nucleotide binding]; other site 361100011979 Cupin domain; Region: Cupin_2; pfam07883 361100011980 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 361100011981 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 361100011982 amphipathic channel; other site 361100011983 Asn-Pro-Ala signature motifs; other site 361100011984 Predicted transcriptional regulator [Transcription]; Region: COG1959 361100011985 Transcriptional regulator; Region: Rrf2; pfam02082 361100011986 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 361100011987 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 361100011988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100011989 Walker A/P-loop; other site 361100011990 ATP binding site [chemical binding]; other site 361100011991 Q-loop/lid; other site 361100011992 ABC transporter signature motif; other site 361100011993 Walker B; other site 361100011994 D-loop; other site 361100011995 H-loop/switch region; other site 361100011996 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 361100011997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100011998 active site 361100011999 motif I; other site 361100012000 motif II; other site 361100012001 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 361100012002 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 361100012003 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 361100012004 ligand binding site [chemical binding]; other site 361100012005 flagellar motor protein MotA; Validated; Region: PRK08124 361100012006 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 361100012007 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 361100012008 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 361100012009 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 361100012010 active site 361100012011 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 361100012012 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 361100012013 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 361100012014 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 361100012015 L-aspartate oxidase; Provisional; Region: PRK06175 361100012016 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 361100012017 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 361100012018 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 361100012019 putative Iron-sulfur protein interface [polypeptide binding]; other site 361100012020 proximal heme binding site [chemical binding]; other site 361100012021 distal heme binding site [chemical binding]; other site 361100012022 putative dimer interface [polypeptide binding]; other site 361100012023 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 361100012024 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 361100012025 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 361100012026 GIY-YIG motif/motif A; other site 361100012027 active site 361100012028 catalytic site [active] 361100012029 putative DNA binding site [nucleotide binding]; other site 361100012030 metal binding site [ion binding]; metal-binding site 361100012031 UvrB/uvrC motif; Region: UVR; pfam02151 361100012032 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 361100012033 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 361100012034 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 361100012035 catalytic residues [active] 361100012036 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 361100012037 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 361100012038 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 361100012039 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 361100012040 Ligand binding site [chemical binding]; other site 361100012041 Electron transfer flavoprotein domain; Region: ETF; pfam01012 361100012042 enoyl-CoA hydratase; Provisional; Region: PRK07658 361100012043 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 361100012044 substrate binding site [chemical binding]; other site 361100012045 oxyanion hole (OAH) forming residues; other site 361100012046 trimer interface [polypeptide binding]; other site 361100012047 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 361100012048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100012049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100012050 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 361100012051 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 361100012052 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 361100012053 acyl-activating enzyme (AAE) consensus motif; other site 361100012054 putative AMP binding site [chemical binding]; other site 361100012055 putative active site [active] 361100012056 putative CoA binding site [chemical binding]; other site 361100012057 DinB family; Region: DinB; pfam05163 361100012058 DinB superfamily; Region: DinB_2; pfam12867 361100012059 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 361100012060 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 361100012061 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 361100012062 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 361100012063 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100012064 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 361100012065 Walker A/P-loop; other site 361100012066 ATP binding site [chemical binding]; other site 361100012067 Q-loop/lid; other site 361100012068 ABC transporter signature motif; other site 361100012069 Walker B; other site 361100012070 D-loop; other site 361100012071 H-loop/switch region; other site 361100012072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100012073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100012074 dimer interface [polypeptide binding]; other site 361100012075 phosphorylation site [posttranslational modification] 361100012076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100012077 ATP binding site [chemical binding]; other site 361100012078 Mg2+ binding site [ion binding]; other site 361100012079 G-X-G motif; other site 361100012080 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100012081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100012082 active site 361100012083 phosphorylation site [posttranslational modification] 361100012084 intermolecular recognition site; other site 361100012085 dimerization interface [polypeptide binding]; other site 361100012086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100012087 DNA binding site [nucleotide binding] 361100012088 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 361100012089 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 361100012090 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 361100012091 putative RNA binding site [nucleotide binding]; other site 361100012092 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 361100012093 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 361100012094 TrkA-N domain; Region: TrkA_N; pfam02254 361100012095 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 361100012096 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 361100012097 active site 361100012098 catalytic site [active] 361100012099 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 361100012100 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 361100012101 Walker A/P-loop; other site 361100012102 ATP binding site [chemical binding]; other site 361100012103 Q-loop/lid; other site 361100012104 ABC transporter signature motif; other site 361100012105 Walker B; other site 361100012106 D-loop; other site 361100012107 H-loop/switch region; other site 361100012108 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100012109 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 361100012110 dimer interface [polypeptide binding]; other site 361100012111 putative PBP binding regions; other site 361100012112 ABC-ATPase subunit interface; other site 361100012113 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 361100012114 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 361100012115 intersubunit interface [polypeptide binding]; other site 361100012116 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 361100012117 heme-binding site [chemical binding]; other site 361100012118 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 361100012119 heme-binding site [chemical binding]; other site 361100012120 CD99 antigen like protein 2; Region: CD99L2; pfam12301 361100012121 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 361100012122 heme-binding site [chemical binding]; other site 361100012123 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 361100012124 heme-binding site [chemical binding]; other site 361100012125 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 361100012126 heme-binding site [chemical binding]; other site 361100012127 heme uptake protein IsdC; Region: IsdC; TIGR03656 361100012128 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 361100012129 heme-binding site [chemical binding]; other site 361100012130 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 361100012131 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 361100012132 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 361100012133 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100012134 RNA binding surface [nucleotide binding]; other site 361100012135 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 361100012136 probable active site [active] 361100012137 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 361100012138 MutS domain III; Region: MutS_III; pfam05192 361100012139 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 361100012140 Walker A/P-loop; other site 361100012141 ATP binding site [chemical binding]; other site 361100012142 Q-loop/lid; other site 361100012143 ABC transporter signature motif; other site 361100012144 Walker B; other site 361100012145 D-loop; other site 361100012146 H-loop/switch region; other site 361100012147 Smr domain; Region: Smr; pfam01713 361100012148 hypothetical protein; Provisional; Region: PRK08609 361100012149 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 361100012150 active site 361100012151 primer binding site [nucleotide binding]; other site 361100012152 NTP binding site [chemical binding]; other site 361100012153 metal binding triad [ion binding]; metal-binding site 361100012154 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 361100012155 active site 361100012156 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 361100012157 Colicin V production protein; Region: Colicin_V; pfam02674 361100012158 cell division protein ZapA; Provisional; Region: PRK14126 361100012159 ribonuclease HIII; Provisional; Region: PRK00996 361100012160 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 361100012161 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 361100012162 RNA/DNA hybrid binding site [nucleotide binding]; other site 361100012163 active site 361100012164 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 361100012165 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 361100012166 putative dimer interface [polypeptide binding]; other site 361100012167 putative anticodon binding site; other site 361100012168 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 361100012169 homodimer interface [polypeptide binding]; other site 361100012170 motif 1; other site 361100012171 motif 2; other site 361100012172 active site 361100012173 motif 3; other site 361100012174 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 361100012175 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 361100012176 putative tRNA-binding site [nucleotide binding]; other site 361100012177 B3/4 domain; Region: B3_4; pfam03483 361100012178 tRNA synthetase B5 domain; Region: B5; smart00874 361100012179 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 361100012180 dimer interface [polypeptide binding]; other site 361100012181 motif 1; other site 361100012182 motif 3; other site 361100012183 motif 2; other site 361100012184 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 361100012185 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 361100012186 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 361100012187 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 361100012188 dimer interface [polypeptide binding]; other site 361100012189 motif 1; other site 361100012190 active site 361100012191 motif 2; other site 361100012192 motif 3; other site 361100012193 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 361100012194 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 361100012195 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 361100012196 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 361100012197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100012198 Zn2+ binding site [ion binding]; other site 361100012199 Mg2+ binding site [ion binding]; other site 361100012200 CAAX protease self-immunity; Region: Abi; pfam02517 361100012201 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 361100012202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100012203 putative substrate translocation pore; other site 361100012204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100012205 HlyD family secretion protein; Region: HlyD_3; pfam13437 361100012206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100012207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100012208 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 361100012209 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 361100012210 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 361100012211 oligomer interface [polypeptide binding]; other site 361100012212 active site 361100012213 metal binding site [ion binding]; metal-binding site 361100012214 dUTPase; Region: dUTPase_2; pfam08761 361100012215 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 361100012216 active site 361100012217 homodimer interface [polypeptide binding]; other site 361100012218 metal binding site [ion binding]; metal-binding site 361100012219 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 361100012220 23S rRNA binding site [nucleotide binding]; other site 361100012221 L21 binding site [polypeptide binding]; other site 361100012222 L13 binding site [polypeptide binding]; other site 361100012223 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 361100012224 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 361100012225 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 361100012226 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 361100012227 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 361100012228 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 361100012229 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 361100012230 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 361100012231 active site 361100012232 dimer interface [polypeptide binding]; other site 361100012233 motif 1; other site 361100012234 motif 2; other site 361100012235 motif 3; other site 361100012236 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 361100012237 anticodon binding site; other site 361100012238 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 361100012239 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 361100012240 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 361100012241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100012242 Walker A motif; other site 361100012243 ATP binding site [chemical binding]; other site 361100012244 Walker B motif; other site 361100012245 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 361100012246 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 361100012247 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 361100012248 ATP cone domain; Region: ATP-cone; pfam03477 361100012249 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 361100012250 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 361100012251 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 361100012252 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 361100012253 dephospho-CoA kinase; Region: TIGR00152 361100012254 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 361100012255 CoA-binding site [chemical binding]; other site 361100012256 ATP-binding [chemical binding]; other site 361100012257 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 361100012258 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 361100012259 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 361100012260 DNA binding site [nucleotide binding] 361100012261 catalytic residue [active] 361100012262 H2TH interface [polypeptide binding]; other site 361100012263 putative catalytic residues [active] 361100012264 turnover-facilitating residue; other site 361100012265 intercalation triad [nucleotide binding]; other site 361100012266 8OG recognition residue [nucleotide binding]; other site 361100012267 putative reading head residues; other site 361100012268 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 361100012269 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 361100012270 DNA polymerase I; Provisional; Region: PRK05755 361100012271 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 361100012272 active site 361100012273 metal binding site 1 [ion binding]; metal-binding site 361100012274 putative 5' ssDNA interaction site; other site 361100012275 metal binding site 3; metal-binding site 361100012276 metal binding site 2 [ion binding]; metal-binding site 361100012277 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 361100012278 putative DNA binding site [nucleotide binding]; other site 361100012279 putative metal binding site [ion binding]; other site 361100012280 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 361100012281 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 361100012282 active site 361100012283 DNA binding site [nucleotide binding] 361100012284 catalytic site [active] 361100012285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100012286 dimerization interface [polypeptide binding]; other site 361100012287 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 361100012288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100012289 putative active site [active] 361100012290 heme pocket [chemical binding]; other site 361100012291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100012292 dimer interface [polypeptide binding]; other site 361100012293 phosphorylation site [posttranslational modification] 361100012294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100012295 ATP binding site [chemical binding]; other site 361100012296 Mg2+ binding site [ion binding]; other site 361100012297 G-X-G motif; other site 361100012298 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100012299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100012300 active site 361100012301 phosphorylation site [posttranslational modification] 361100012302 intermolecular recognition site; other site 361100012303 dimerization interface [polypeptide binding]; other site 361100012304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100012305 DNA binding site [nucleotide binding] 361100012306 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 361100012307 active site 2 [active] 361100012308 active site 1 [active] 361100012309 malate dehydrogenase; Reviewed; Region: PRK06223 361100012310 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 361100012311 NAD(P) binding site [chemical binding]; other site 361100012312 dimer interface [polypeptide binding]; other site 361100012313 tetramer (dimer of dimers) interface [polypeptide binding]; other site 361100012314 substrate binding site [chemical binding]; other site 361100012315 isocitrate dehydrogenase; Reviewed; Region: PRK07006 361100012316 isocitrate dehydrogenase; Validated; Region: PRK07362 361100012317 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 361100012318 dimer interface [polypeptide binding]; other site 361100012319 Citrate synthase; Region: Citrate_synt; pfam00285 361100012320 active site 361100012321 citrylCoA binding site [chemical binding]; other site 361100012322 oxalacetate/citrate binding site [chemical binding]; other site 361100012323 coenzyme A binding site [chemical binding]; other site 361100012324 catalytic triad [active] 361100012325 Protein of unknown function (DUF441); Region: DUF441; pfam04284 361100012326 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 361100012327 Domain of unknown function DUF20; Region: UPF0118; pfam01594 361100012328 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 361100012329 pyruvate kinase; Provisional; Region: PRK06354 361100012330 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 361100012331 domain interfaces; other site 361100012332 active site 361100012333 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 361100012334 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 361100012335 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 361100012336 active site 361100012337 ADP/pyrophosphate binding site [chemical binding]; other site 361100012338 dimerization interface [polypeptide binding]; other site 361100012339 allosteric effector site; other site 361100012340 fructose-1,6-bisphosphate binding site; other site 361100012341 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 361100012342 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 361100012343 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 361100012344 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 361100012345 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 361100012346 Transcriptional regulators [Transcription]; Region: FadR; COG2186 361100012347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100012348 DNA-binding site [nucleotide binding]; DNA binding site 361100012349 Malic enzyme, N-terminal domain; Region: malic; pfam00390 361100012350 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 361100012351 putative NAD(P) binding site [chemical binding]; other site 361100012352 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 361100012353 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 361100012354 active site 361100012355 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 361100012356 generic binding surface II; other site 361100012357 generic binding surface I; other site 361100012358 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 361100012359 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 361100012360 DHH family; Region: DHH; pfam01368 361100012361 DHHA1 domain; Region: DHHA1; pfam02272 361100012362 YtpI-like protein; Region: YtpI; pfam14007 361100012363 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 361100012364 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 361100012365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100012366 DNA-binding site [nucleotide binding]; DNA binding site 361100012367 DRTGG domain; Region: DRTGG; pfam07085 361100012368 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 361100012369 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 361100012370 active site 2 [active] 361100012371 active site 1 [active] 361100012372 metal-dependent hydrolase; Provisional; Region: PRK00685 361100012373 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 361100012374 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 361100012375 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 361100012376 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 361100012377 active site 361100012378 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 361100012379 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 361100012380 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 361100012381 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 361100012382 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 361100012383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100012384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 361100012385 DNA binding residues [nucleotide binding] 361100012386 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 361100012387 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100012388 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 361100012389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 361100012390 Transposase; Region: HTH_Tnp_1; cl17663 361100012391 Helix-turn-helix domain; Region: HTH_28; pfam13518 361100012392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 361100012393 HTH-like domain; Region: HTH_21; pfam13276 361100012394 Integrase core domain; Region: rve; pfam00665 361100012395 Integrase core domain; Region: rve_2; pfam13333 361100012396 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 361100012397 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 361100012398 hexamer interface [polypeptide binding]; other site 361100012399 ligand binding site [chemical binding]; other site 361100012400 putative active site [active] 361100012401 NAD(P) binding site [chemical binding]; other site 361100012402 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 361100012403 classical (c) SDRs; Region: SDR_c; cd05233 361100012404 NAD(P) binding site [chemical binding]; other site 361100012405 active site 361100012406 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 361100012407 Ligand Binding Site [chemical binding]; other site 361100012408 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100012409 dimerization interface [polypeptide binding]; other site 361100012410 putative DNA binding site [nucleotide binding]; other site 361100012411 putative Zn2+ binding site [ion binding]; other site 361100012412 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100012413 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 361100012414 active site 361100012415 substrate binding site [chemical binding]; other site 361100012416 ATP binding site [chemical binding]; other site 361100012417 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 361100012418 activation loop (A-loop); other site 361100012419 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 361100012420 active site 361100012421 zinc binding site [ion binding]; other site 361100012422 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100012423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 361100012424 Integrase core domain; Region: rve; pfam00665 361100012425 transposase/IS protein; Provisional; Region: PRK09183 361100012426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100012427 Walker A motif; other site 361100012428 ATP binding site [chemical binding]; other site 361100012429 Walker B motif; other site 361100012430 DinB superfamily; Region: DinB_2; pfam12867 361100012431 argininosuccinate lyase; Provisional; Region: PRK00855 361100012432 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 361100012433 active sites [active] 361100012434 tetramer interface [polypeptide binding]; other site 361100012435 argininosuccinate synthase; Provisional; Region: PRK13820 361100012436 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 361100012437 ANP binding site [chemical binding]; other site 361100012438 Substrate Binding Site II [chemical binding]; other site 361100012439 Substrate Binding Site I [chemical binding]; other site 361100012440 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100012441 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100012442 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100012443 EcsC protein family; Region: EcsC; pfam12787 361100012444 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 361100012445 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 361100012446 nudix motif; other site 361100012447 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 361100012448 propionate/acetate kinase; Provisional; Region: PRK12379 361100012449 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 361100012450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100012451 S-adenosylmethionine binding site [chemical binding]; other site 361100012452 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 361100012453 dimer interface [polypeptide binding]; other site 361100012454 catalytic triad [active] 361100012455 peroxidatic and resolving cysteines [active] 361100012456 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 361100012457 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 361100012458 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 361100012459 ATP-NAD kinase; Region: NAD_kinase; pfam01513 361100012460 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 361100012461 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 361100012462 active site 361100012463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100012464 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 361100012465 dimer interface [polypeptide binding]; other site 361100012466 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 361100012467 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 361100012468 active site 361100012469 acyl-activating enzyme (AAE) consensus motif; other site 361100012470 putative CoA binding site [chemical binding]; other site 361100012471 AMP binding site [chemical binding]; other site 361100012472 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 361100012473 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 361100012474 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 361100012475 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 361100012476 Ligand Binding Site [chemical binding]; other site 361100012477 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 361100012478 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 361100012479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100012480 catalytic residue [active] 361100012481 septation ring formation regulator EzrA; Provisional; Region: PRK04778 361100012482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100012483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100012484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 361100012485 dimerization interface [polypeptide binding]; other site 361100012486 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100012487 EamA-like transporter family; Region: EamA; pfam00892 361100012488 EamA-like transporter family; Region: EamA; pfam00892 361100012489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100012490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100012491 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 361100012492 GAF domain; Region: GAF_2; pfam13185 361100012493 methionine gamma-lyase; Provisional; Region: PRK06767 361100012494 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 361100012495 homodimer interface [polypeptide binding]; other site 361100012496 substrate-cofactor binding pocket; other site 361100012497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100012498 catalytic residue [active] 361100012499 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 361100012500 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 361100012501 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100012502 RNA binding surface [nucleotide binding]; other site 361100012503 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 361100012504 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 361100012505 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 361100012506 active site 361100012507 HIGH motif; other site 361100012508 dimer interface [polypeptide binding]; other site 361100012509 KMSKS motif; other site 361100012510 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100012511 RNA binding surface [nucleotide binding]; other site 361100012512 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 361100012513 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100012514 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100012515 DNA binding residues [nucleotide binding] 361100012516 acetyl-CoA synthetase; Provisional; Region: PRK04319 361100012517 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 361100012518 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 361100012519 active site 361100012520 acyl-activating enzyme (AAE) consensus motif; other site 361100012521 putative CoA binding site [chemical binding]; other site 361100012522 AMP binding site [chemical binding]; other site 361100012523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100012524 Coenzyme A binding pocket [chemical binding]; other site 361100012525 FOG: CBS domain [General function prediction only]; Region: COG0517 361100012526 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 361100012527 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 361100012528 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 361100012529 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 361100012530 active site 361100012531 Zn binding site [ion binding]; other site 361100012532 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 361100012533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100012534 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100012535 active site 361100012536 phosphorylation site [posttranslational modification] 361100012537 intermolecular recognition site; other site 361100012538 dimerization interface [polypeptide binding]; other site 361100012539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100012540 DNA binding site [nucleotide binding] 361100012541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100012542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100012543 dimerization interface [polypeptide binding]; other site 361100012544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100012545 dimer interface [polypeptide binding]; other site 361100012546 phosphorylation site [posttranslational modification] 361100012547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100012548 ATP binding site [chemical binding]; other site 361100012549 Mg2+ binding site [ion binding]; other site 361100012550 G-X-G motif; other site 361100012551 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 361100012552 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 361100012553 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 361100012554 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 361100012555 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 361100012556 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 361100012557 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 361100012558 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 361100012559 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 361100012560 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 361100012561 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 361100012562 catabolite control protein A; Region: ccpA; TIGR01481 361100012563 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 361100012564 DNA binding site [nucleotide binding] 361100012565 domain linker motif; other site 361100012566 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 361100012567 dimerization interface [polypeptide binding]; other site 361100012568 effector binding site; other site 361100012569 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 361100012570 putative dimer interface [polypeptide binding]; other site 361100012571 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 361100012572 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 361100012573 putative dimer interface [polypeptide binding]; other site 361100012574 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 361100012575 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 361100012576 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 361100012577 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 361100012578 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 361100012579 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 361100012580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100012581 Coenzyme A binding pocket [chemical binding]; other site 361100012582 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100012583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100012584 Coenzyme A binding pocket [chemical binding]; other site 361100012585 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 361100012586 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 361100012587 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 361100012588 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 361100012589 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 361100012590 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 361100012591 active site 361100012592 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 361100012593 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 361100012594 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 361100012595 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 361100012596 putative tRNA-binding site [nucleotide binding]; other site 361100012597 hypothetical protein; Provisional; Region: PRK13668 361100012598 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 361100012599 catalytic residues [active] 361100012600 NTPase; Reviewed; Region: PRK03114 361100012601 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 361100012602 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 361100012603 oligomer interface [polypeptide binding]; other site 361100012604 active site 361100012605 metal binding site [ion binding]; metal-binding site 361100012606 Predicted small secreted protein [Function unknown]; Region: COG5584 361100012607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100012608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100012609 S-adenosylmethionine binding site [chemical binding]; other site 361100012610 YtzH-like protein; Region: YtzH; pfam14165 361100012611 Phosphotransferase enzyme family; Region: APH; pfam01636 361100012612 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 361100012613 active site 361100012614 substrate binding site [chemical binding]; other site 361100012615 ATP binding site [chemical binding]; other site 361100012616 pullulanase, type I; Region: pulA_typeI; TIGR02104 361100012617 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 361100012618 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 361100012619 Ca binding site [ion binding]; other site 361100012620 active site 361100012621 catalytic site [active] 361100012622 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 361100012623 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 361100012624 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 361100012625 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 361100012626 dipeptidase PepV; Reviewed; Region: PRK07318 361100012627 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 361100012628 active site 361100012629 metal binding site [ion binding]; metal-binding site 361100012630 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 361100012631 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 361100012632 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 361100012633 RNA binding surface [nucleotide binding]; other site 361100012634 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 361100012635 active site 361100012636 uracil binding [chemical binding]; other site 361100012637 stage V sporulation protein B; Region: spore_V_B; TIGR02900 361100012638 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 361100012639 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 361100012640 HI0933-like protein; Region: HI0933_like; pfam03486 361100012641 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100012642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100012643 putative substrate translocation pore; other site 361100012644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100012645 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100012646 dimerization interface [polypeptide binding]; other site 361100012647 putative DNA binding site [nucleotide binding]; other site 361100012648 putative Zn2+ binding site [ion binding]; other site 361100012649 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 361100012650 putative hydrophobic ligand binding site [chemical binding]; other site 361100012651 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 361100012652 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 361100012653 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 361100012654 glucose-1-dehydrogenase; Provisional; Region: PRK08936 361100012655 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 361100012656 NAD binding site [chemical binding]; other site 361100012657 homodimer interface [polypeptide binding]; other site 361100012658 active site 361100012659 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 361100012660 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 361100012661 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 361100012662 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 361100012663 MoaE interaction surface [polypeptide binding]; other site 361100012664 MoeB interaction surface [polypeptide binding]; other site 361100012665 thiocarboxylated glycine; other site 361100012666 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 361100012667 MoaE homodimer interface [polypeptide binding]; other site 361100012668 MoaD interaction [polypeptide binding]; other site 361100012669 active site residues [active] 361100012670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 361100012671 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 361100012672 Probable transposase; Region: OrfB_IS605; pfam01385 361100012673 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 361100012674 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 361100012675 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100012676 DNA binding residues [nucleotide binding] 361100012677 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 361100012678 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 361100012679 Walker A motif; other site 361100012680 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 361100012681 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 361100012682 dimer interface [polypeptide binding]; other site 361100012683 putative functional site; other site 361100012684 putative MPT binding site; other site 361100012685 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 361100012686 trimer interface [polypeptide binding]; other site 361100012687 dimer interface [polypeptide binding]; other site 361100012688 putative active site [active] 361100012689 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 361100012690 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 361100012691 ATP binding site [chemical binding]; other site 361100012692 substrate interface [chemical binding]; other site 361100012693 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 361100012694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100012695 FeS/SAM binding site; other site 361100012696 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 361100012697 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 361100012698 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 361100012699 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 361100012700 active site residue [active] 361100012701 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 361100012702 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 361100012703 Vicilin N terminal region; Region: Vicilin_N; pfam04702 361100012704 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100012705 Spore germination protein; Region: Spore_permease; pfam03845 361100012706 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100012707 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100012708 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 361100012709 putative nucleotide binding site [chemical binding]; other site 361100012710 putative metal binding site [ion binding]; other site 361100012711 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 361100012712 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 361100012713 HIGH motif; other site 361100012714 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 361100012715 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 361100012716 active site 361100012717 KMSKS motif; other site 361100012718 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 361100012719 tRNA binding surface [nucleotide binding]; other site 361100012720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100012721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100012722 putative substrate translocation pore; other site 361100012723 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 361100012724 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 361100012725 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 361100012726 TrkA-C domain; Region: TrkA_C; pfam02080 361100012727 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 361100012728 Int/Topo IB signature motif; other site 361100012729 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100012730 FtsX-like permease family; Region: FtsX; pfam02687 361100012731 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100012732 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100012733 Walker A/P-loop; other site 361100012734 ATP binding site [chemical binding]; other site 361100012735 Q-loop/lid; other site 361100012736 ABC transporter signature motif; other site 361100012737 Walker B; other site 361100012738 D-loop; other site 361100012739 H-loop/switch region; other site 361100012740 Protein of unknown function (DUF418); Region: DUF418; cl12135 361100012741 Protein of unknown function (DUF418); Region: DUF418; pfam04235 361100012742 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 361100012743 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 361100012744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100012745 FeS/SAM binding site; other site 361100012746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100012747 S-adenosylmethionine binding site [chemical binding]; other site 361100012748 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 361100012749 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100012750 Walker A/P-loop; other site 361100012751 ATP binding site [chemical binding]; other site 361100012752 Q-loop/lid; other site 361100012753 ABC transporter signature motif; other site 361100012754 Walker B; other site 361100012755 D-loop; other site 361100012756 H-loop/switch region; other site 361100012757 aspartate racemase; Region: asp_race; TIGR00035 361100012758 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 361100012759 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 361100012760 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 361100012761 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 361100012762 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 361100012763 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 361100012764 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100012765 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 361100012766 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 361100012767 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 361100012768 trimer interface [polypeptide binding]; other site 361100012769 putative metal binding site [ion binding]; other site 361100012770 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 361100012771 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 361100012772 active site 361100012773 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 361100012774 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 361100012775 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 361100012776 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 361100012777 GTP binding site; other site 361100012778 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 361100012779 MPT binding site; other site 361100012780 trimer interface [polypeptide binding]; other site 361100012781 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100012782 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100012783 S-adenosylmethionine synthetase; Validated; Region: PRK05250 361100012784 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 361100012785 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 361100012786 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 361100012787 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 361100012788 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 361100012789 active site 361100012790 substrate-binding site [chemical binding]; other site 361100012791 metal-binding site [ion binding] 361100012792 ATP binding site [chemical binding]; other site 361100012793 ATP synthase I chain; Region: ATP_synt_I; pfam03899 361100012794 EamA-like transporter family; Region: EamA; pfam00892 361100012795 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 361100012796 EamA-like transporter family; Region: EamA; pfam00892 361100012797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 361100012798 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100012799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100012800 ATP binding site [chemical binding]; other site 361100012801 Mg2+ binding site [ion binding]; other site 361100012802 G-X-G motif; other site 361100012803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100012804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100012805 dimer interface [polypeptide binding]; other site 361100012806 phosphorylation site [posttranslational modification] 361100012807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100012808 ATP binding site [chemical binding]; other site 361100012809 Mg2+ binding site [ion binding]; other site 361100012810 G-X-G motif; other site 361100012811 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100012812 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 361100012813 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 361100012814 Sulfatase; Region: Sulfatase; pfam00884 361100012815 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 361100012816 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 361100012817 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 361100012818 NMT1-like family; Region: NMT1_2; pfam13379 361100012819 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 361100012820 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 361100012821 Walker A/P-loop; other site 361100012822 ATP binding site [chemical binding]; other site 361100012823 Q-loop/lid; other site 361100012824 ABC transporter signature motif; other site 361100012825 Walker B; other site 361100012826 D-loop; other site 361100012827 H-loop/switch region; other site 361100012828 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 361100012829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100012830 dimer interface [polypeptide binding]; other site 361100012831 conserved gate region; other site 361100012832 putative PBP binding loops; other site 361100012833 ABC-ATPase subunit interface; other site 361100012834 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 361100012835 active site 361100012836 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 361100012837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100012838 motif II; other site 361100012839 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 361100012840 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 361100012841 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 361100012842 nudix motif; other site 361100012843 S-ribosylhomocysteinase; Provisional; Region: PRK02260 361100012844 Haemolytic domain; Region: Haemolytic; pfam01809 361100012845 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 361100012846 active site clefts [active] 361100012847 zinc binding site [ion binding]; other site 361100012848 dimer interface [polypeptide binding]; other site 361100012849 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 361100012850 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 361100012851 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 361100012852 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 361100012853 S-layer homology domain; Region: SLH; pfam00395 361100012854 S-layer homology domain; Region: SLH; pfam00395 361100012855 S-layer homology domain; Region: SLH; pfam00395 361100012856 Excalibur calcium-binding domain; Region: Excalibur; smart00894 361100012857 Uncharacterized conserved protein [Function unknown]; Region: COG1434 361100012858 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 361100012859 putative active site [active] 361100012860 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100012861 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100012862 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100012863 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100012864 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 361100012865 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 361100012866 Predicted membrane protein [Function unknown]; Region: COG3766 361100012867 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 361100012868 hypothetical protein; Provisional; Region: PRK12473 361100012869 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 361100012870 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 361100012871 G1 box; other site 361100012872 GTP/Mg2+ binding site [chemical binding]; other site 361100012873 Switch I region; other site 361100012874 G2 box; other site 361100012875 G3 box; other site 361100012876 Switch II region; other site 361100012877 G4 box; other site 361100012878 G5 box; other site 361100012879 Nucleoside recognition; Region: Gate; pfam07670 361100012880 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 361100012881 Nucleoside recognition; Region: Gate; pfam07670 361100012882 FeoA domain; Region: FeoA; pfam04023 361100012883 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 361100012884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100012885 dimerization interface [polypeptide binding]; other site 361100012886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100012887 dimer interface [polypeptide binding]; other site 361100012888 phosphorylation site [posttranslational modification] 361100012889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100012890 ATP binding site [chemical binding]; other site 361100012891 Mg2+ binding site [ion binding]; other site 361100012892 G-X-G motif; other site 361100012893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100012894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100012895 active site 361100012896 phosphorylation site [posttranslational modification] 361100012897 intermolecular recognition site; other site 361100012898 dimerization interface [polypeptide binding]; other site 361100012899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100012900 DNA binding site [nucleotide binding] 361100012901 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 361100012902 active site 361100012903 catalytic site [active] 361100012904 S-layer homology domain; Region: SLH; pfam00395 361100012905 S-layer homology domain; Region: SLH; pfam00395 361100012906 S-layer homology domain; Region: SLH; pfam00395 361100012907 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 361100012908 putative active site [active] 361100012909 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 361100012910 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100012911 active site 361100012912 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 361100012913 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 361100012914 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 361100012915 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 361100012916 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100012917 FtsX-like permease family; Region: FtsX; pfam02687 361100012918 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100012919 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100012920 Walker A/P-loop; other site 361100012921 ATP binding site [chemical binding]; other site 361100012922 Q-loop/lid; other site 361100012923 ABC transporter signature motif; other site 361100012924 Walker B; other site 361100012925 D-loop; other site 361100012926 H-loop/switch region; other site 361100012927 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 361100012928 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 361100012929 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 361100012930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100012931 S-adenosylmethionine binding site [chemical binding]; other site 361100012932 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 361100012933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100012934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100012935 YolD-like protein; Region: YolD; pfam08863 361100012936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 361100012937 HTH-like domain; Region: HTH_21; pfam13276 361100012938 Integrase core domain; Region: rve; pfam00665 361100012939 Integrase core domain; Region: rve_2; pfam13333 361100012940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 361100012941 Transposase; Region: HTH_Tnp_1; cl17663 361100012942 Helix-turn-helix domain; Region: HTH_28; pfam13518 361100012943 FtsX-like permease family; Region: FtsX; pfam02687 361100012944 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100012945 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100012946 Walker A/P-loop; other site 361100012947 ATP binding site [chemical binding]; other site 361100012948 Q-loop/lid; other site 361100012949 ABC transporter signature motif; other site 361100012950 Walker B; other site 361100012951 D-loop; other site 361100012952 H-loop/switch region; other site 361100012953 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 361100012954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100012955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 361100012956 Predicted integral membrane protein [Function unknown]; Region: COG5658 361100012957 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 361100012958 SdpI/YhfL protein family; Region: SdpI; pfam13630 361100012959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100012960 dimerization interface [polypeptide binding]; other site 361100012961 putative DNA binding site [nucleotide binding]; other site 361100012962 putative Zn2+ binding site [ion binding]; other site 361100012963 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100012964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100012965 active site 361100012966 phosphorylation site [posttranslational modification] 361100012967 intermolecular recognition site; other site 361100012968 dimerization interface [polypeptide binding]; other site 361100012969 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100012970 DNA binding site [nucleotide binding] 361100012971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100012972 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 361100012973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100012974 ATP binding site [chemical binding]; other site 361100012975 Mg2+ binding site [ion binding]; other site 361100012976 G-X-G motif; other site 361100012977 FtsX-like permease family; Region: FtsX; pfam02687 361100012978 FtsX-like permease family; Region: FtsX; pfam02687 361100012979 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100012980 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100012981 Walker A/P-loop; other site 361100012982 ATP binding site [chemical binding]; other site 361100012983 Q-loop/lid; other site 361100012984 ABC transporter signature motif; other site 361100012985 Walker B; other site 361100012986 D-loop; other site 361100012987 H-loop/switch region; other site 361100012988 FtsX-like permease family; Region: FtsX; pfam02687 361100012989 GntP family permease; Region: GntP_permease; pfam02447 361100012990 fructuronate transporter; Provisional; Region: PRK10034; cl15264 361100012991 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 361100012992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100012993 DNA-binding site [nucleotide binding]; DNA binding site 361100012994 UTRA domain; Region: UTRA; pfam07702 361100012995 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 361100012996 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 361100012997 substrate binding site [chemical binding]; other site 361100012998 ATP binding site [chemical binding]; other site 361100012999 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 361100013000 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 361100013001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100013002 catalytic residue [active] 361100013003 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 361100013004 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 361100013005 active site 361100013006 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 361100013007 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 361100013008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100013009 dimerization interface [polypeptide binding]; other site 361100013010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100013011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100013012 dimer interface [polypeptide binding]; other site 361100013013 phosphorylation site [posttranslational modification] 361100013014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100013015 ATP binding site [chemical binding]; other site 361100013016 Mg2+ binding site [ion binding]; other site 361100013017 G-X-G motif; other site 361100013018 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100013019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100013020 active site 361100013021 phosphorylation site [posttranslational modification] 361100013022 intermolecular recognition site; other site 361100013023 dimerization interface [polypeptide binding]; other site 361100013024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100013025 DNA binding site [nucleotide binding] 361100013026 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 361100013027 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 361100013028 active site 361100013029 octamer interface [polypeptide binding]; other site 361100013030 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 361100013031 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 361100013032 acyl-activating enzyme (AAE) consensus motif; other site 361100013033 putative AMP binding site [chemical binding]; other site 361100013034 putative active site [active] 361100013035 putative CoA binding site [chemical binding]; other site 361100013036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 361100013037 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 361100013038 substrate binding site [chemical binding]; other site 361100013039 oxyanion hole (OAH) forming residues; other site 361100013040 trimer interface [polypeptide binding]; other site 361100013041 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 361100013042 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 361100013043 nucleophilic elbow; other site 361100013044 catalytic triad; other site 361100013045 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 361100013046 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 361100013047 dimer interface [polypeptide binding]; other site 361100013048 tetramer interface [polypeptide binding]; other site 361100013049 PYR/PP interface [polypeptide binding]; other site 361100013050 TPP binding site [chemical binding]; other site 361100013051 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 361100013052 TPP-binding site; other site 361100013053 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 361100013054 chorismate binding enzyme; Region: Chorismate_bind; cl10555 361100013055 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 361100013056 UbiA prenyltransferase family; Region: UbiA; pfam01040 361100013057 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 361100013058 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 361100013059 DNA-binding site [nucleotide binding]; DNA binding site 361100013060 RNA-binding motif; other site 361100013061 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 361100013062 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 361100013063 active site flap/lid [active] 361100013064 nucleophilic elbow; other site 361100013065 catalytic triad [active] 361100013066 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 361100013067 homodimer interface [polypeptide binding]; other site 361100013068 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 361100013069 active site pocket [active] 361100013070 glycogen synthase; Provisional; Region: glgA; PRK00654 361100013071 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 361100013072 ADP-binding pocket [chemical binding]; other site 361100013073 homodimer interface [polypeptide binding]; other site 361100013074 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 361100013075 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 361100013076 ligand binding site; other site 361100013077 oligomer interface; other site 361100013078 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 361100013079 dimer interface [polypeptide binding]; other site 361100013080 N-terminal domain interface [polypeptide binding]; other site 361100013081 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 361100013082 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 361100013083 ligand binding site; other site 361100013084 oligomer interface; other site 361100013085 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 361100013086 dimer interface [polypeptide binding]; other site 361100013087 N-terminal domain interface [polypeptide binding]; other site 361100013088 sulfate 1 binding site; other site 361100013089 glycogen branching enzyme; Provisional; Region: PRK12313 361100013090 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 361100013091 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 361100013092 active site 361100013093 catalytic site [active] 361100013094 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 361100013095 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 361100013096 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 361100013097 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 361100013098 putative active site [active] 361100013099 catalytic triad [active] 361100013100 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 361100013101 PA/protease domain interface [polypeptide binding]; other site 361100013102 putative integrin binding motif; other site 361100013103 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 361100013104 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 361100013105 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 361100013106 dockerin binding interface; other site 361100013107 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 361100013108 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 361100013109 tetramer (dimer of dimers) interface [polypeptide binding]; other site 361100013110 NAD binding site [chemical binding]; other site 361100013111 dimer interface [polypeptide binding]; other site 361100013112 substrate binding site [chemical binding]; other site 361100013113 potential protein location (conserved hypothetical protein [Bacillus cereus Q1]) that overlaps RNA (23S ribosomal RNA) 361100013114 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 361100013115 MgtC family; Region: MgtC; pfam02308 361100013116 Ion channel; Region: Ion_trans_2; pfam07885 361100013117 TrkA-N domain; Region: TrkA_N; pfam02254 361100013118 YugN-like family; Region: YugN; pfam08868 361100013119 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 361100013120 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 361100013121 active site 361100013122 dimer interface [polypeptide binding]; other site 361100013123 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 361100013124 dimer interface [polypeptide binding]; other site 361100013125 active site 361100013126 Domain of unknown function (DUF378); Region: DUF378; pfam04070 361100013127 general stress protein 13; Validated; Region: PRK08059 361100013128 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 361100013129 RNA binding site [nucleotide binding]; other site 361100013130 hypothetical protein; Validated; Region: PRK07682 361100013131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100013132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100013133 homodimer interface [polypeptide binding]; other site 361100013134 catalytic residue [active] 361100013135 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 361100013136 AsnC family; Region: AsnC_trans_reg; pfam01037 361100013137 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 361100013138 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 361100013139 dimerization interface [polypeptide binding]; other site 361100013140 ligand binding site [chemical binding]; other site 361100013141 NADP binding site [chemical binding]; other site 361100013142 catalytic site [active] 361100013143 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 361100013144 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 361100013145 nucleophilic elbow; other site 361100013146 catalytic triad; other site 361100013147 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 361100013148 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 361100013149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 361100013150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100013151 homodimer interface [polypeptide binding]; other site 361100013152 catalytic residue [active] 361100013153 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 361100013154 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 361100013155 E-class dimer interface [polypeptide binding]; other site 361100013156 P-class dimer interface [polypeptide binding]; other site 361100013157 active site 361100013158 Cu2+ binding site [ion binding]; other site 361100013159 Zn2+ binding site [ion binding]; other site 361100013160 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 361100013161 Kinase associated protein B; Region: KapB; pfam08810 361100013162 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 361100013163 active site 361100013164 catalytic site [active] 361100013165 substrate binding site [chemical binding]; other site 361100013166 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 361100013167 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 361100013168 transmembrane helices; other site 361100013169 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 361100013170 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 361100013171 active site 361100013172 glycyl-tRNA synthetase; Provisional; Region: PRK04173 361100013173 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 361100013174 motif 1; other site 361100013175 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 361100013176 active site 361100013177 motif 2; other site 361100013178 motif 3; other site 361100013179 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 361100013180 anticodon binding site; other site 361100013181 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 361100013182 CoenzymeA binding site [chemical binding]; other site 361100013183 subunit interaction site [polypeptide binding]; other site 361100013184 PHB binding site; other site 361100013185 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 361100013186 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 361100013187 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 361100013188 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 361100013189 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 361100013190 active site 361100013191 tetramer interface; other site 361100013192 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 361100013193 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 361100013194 active site 361100013195 substrate binding site [chemical binding]; other site 361100013196 metal binding site [ion binding]; metal-binding site 361100013197 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 361100013198 Uncharacterized conserved protein [Function unknown]; Region: COG1624 361100013199 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 361100013200 multifunctional aminopeptidase A; Provisional; Region: PRK00913 361100013201 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 361100013202 interface (dimer of trimers) [polypeptide binding]; other site 361100013203 Substrate-binding/catalytic site; other site 361100013204 Zn-binding sites [ion binding]; other site 361100013205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 361100013206 Putative membrane protein; Region: YuiB; pfam14068 361100013207 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 361100013208 nudix motif; other site 361100013209 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 361100013210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100013211 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 361100013212 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 361100013213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100013214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 361100013215 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100013216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100013217 putative substrate translocation pore; other site 361100013218 Helix-turn-helix domain; Region: HTH_36; pfam13730 361100013219 Uncharacterized conserved protein [Function unknown]; Region: COG1683 361100013220 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 361100013221 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100013222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100013223 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 361100013224 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 361100013225 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 361100013226 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 361100013227 hypothetical protein; Provisional; Region: PRK13669 361100013228 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 361100013229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100013230 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100013231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100013232 Walker A/P-loop; other site 361100013233 ATP binding site [chemical binding]; other site 361100013234 Q-loop/lid; other site 361100013235 ABC transporter signature motif; other site 361100013236 Walker B; other site 361100013237 D-loop; other site 361100013238 H-loop/switch region; other site 361100013239 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 361100013240 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 361100013241 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 361100013242 PhnA protein; Region: PhnA; pfam03831 361100013243 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 361100013244 PQQ-like domain; Region: PQQ_2; pfam13360 361100013245 PQQ-like domain; Region: PQQ_2; pfam13360 361100013246 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 361100013247 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 361100013248 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 361100013249 CAAX protease self-immunity; Region: Abi; pfam02517 361100013250 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 361100013251 active site 361100013252 NTP binding site [chemical binding]; other site 361100013253 metal binding triad [ion binding]; metal-binding site 361100013254 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 361100013255 NifU-like domain; Region: NifU; pfam01106 361100013256 spore coat protein YutH; Region: spore_yutH; TIGR02905 361100013257 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 361100013258 tetramer interfaces [polypeptide binding]; other site 361100013259 binuclear metal-binding site [ion binding]; other site 361100013260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100013261 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 361100013262 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 361100013263 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 361100013264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100013265 active site 361100013266 motif I; other site 361100013267 motif II; other site 361100013268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100013269 Predicted transcriptional regulator [Transcription]; Region: COG2345 361100013270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100013271 putative Zn2+ binding site [ion binding]; other site 361100013272 putative DNA binding site [nucleotide binding]; other site 361100013273 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 361100013274 Uncharacterized conserved protein [Function unknown]; Region: COG2445 361100013275 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 361100013276 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 361100013277 putative active site [active] 361100013278 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 361100013279 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 361100013280 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100013281 RNA binding surface [nucleotide binding]; other site 361100013282 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 361100013283 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 361100013284 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 361100013285 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 361100013286 DNA binding residues [nucleotide binding] 361100013287 dimer interface [polypeptide binding]; other site 361100013288 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 361100013289 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 361100013290 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 361100013291 catalytic core [active] 361100013292 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 361100013293 putative deacylase active site [active] 361100013294 lipoyl synthase; Provisional; Region: PRK05481 361100013295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100013296 FeS/SAM binding site; other site 361100013297 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 361100013298 Peptidase family M23; Region: Peptidase_M23; pfam01551 361100013299 sporulation protein YunB; Region: spo_yunB; TIGR02832 361100013300 Uncharacterized conserved protein [Function unknown]; Region: COG3377 361100013301 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 361100013302 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 361100013303 active site 361100013304 metal binding site [ion binding]; metal-binding site 361100013305 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 361100013306 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 361100013307 FeS assembly protein SufB; Region: sufB; TIGR01980 361100013308 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 361100013309 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 361100013310 trimerization site [polypeptide binding]; other site 361100013311 active site 361100013312 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 361100013313 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 361100013314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 361100013315 catalytic residue [active] 361100013316 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 361100013317 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 361100013318 FeS assembly protein SufD; Region: sufD; TIGR01981 361100013319 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 361100013320 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 361100013321 Walker A/P-loop; other site 361100013322 ATP binding site [chemical binding]; other site 361100013323 Q-loop/lid; other site 361100013324 ABC transporter signature motif; other site 361100013325 Walker B; other site 361100013326 D-loop; other site 361100013327 H-loop/switch region; other site 361100013328 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 361100013329 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 361100013330 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 361100013331 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 361100013332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 361100013333 ABC-ATPase subunit interface; other site 361100013334 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 361100013335 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 361100013336 Walker A/P-loop; other site 361100013337 ATP binding site [chemical binding]; other site 361100013338 Q-loop/lid; other site 361100013339 ABC transporter signature motif; other site 361100013340 Walker B; other site 361100013341 D-loop; other site 361100013342 H-loop/switch region; other site 361100013343 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 361100013344 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 361100013345 catalytic residues [active] 361100013346 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 361100013347 putative active site [active] 361100013348 putative metal binding site [ion binding]; other site 361100013349 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 361100013350 lipoyl attachment site [posttranslational modification]; other site 361100013351 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 361100013352 ArsC family; Region: ArsC; pfam03960 361100013353 putative ArsC-like catalytic residues; other site 361100013354 putative TRX-like catalytic residues [active] 361100013355 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 361100013356 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 361100013357 active site 361100013358 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 361100013359 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 361100013360 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 361100013361 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 361100013362 tetramer (dimer of dimers) interface [polypeptide binding]; other site 361100013363 NAD binding site [chemical binding]; other site 361100013364 dimer interface [polypeptide binding]; other site 361100013365 substrate binding site [chemical binding]; other site 361100013366 Coat F domain; Region: Coat_F; pfam07875 361100013367 CAAX protease self-immunity; Region: Abi; pfam02517 361100013368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100013369 salt bridge; other site 361100013370 non-specific DNA binding site [nucleotide binding]; other site 361100013371 sequence-specific DNA binding site [nucleotide binding]; other site 361100013372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100013373 WHG domain; Region: WHG; pfam13305 361100013374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 361100013375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 361100013376 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 361100013377 active site 361100013378 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 361100013379 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 361100013380 dimer interface [polypeptide binding]; other site 361100013381 active site 361100013382 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 361100013383 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 361100013384 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 361100013385 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 361100013386 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 361100013387 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 361100013388 substrate binding site [chemical binding]; other site 361100013389 oxyanion hole (OAH) forming residues; other site 361100013390 YuzL-like protein; Region: YuzL; pfam14115 361100013391 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100013392 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 361100013393 Proline dehydrogenase; Region: Pro_dh; cl03282 361100013394 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 361100013395 Domain of unknown function DUF77; Region: DUF77; pfam01910 361100013396 Cache domain; Region: Cache_1; pfam02743 361100013397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100013398 dimerization interface [polypeptide binding]; other site 361100013399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100013400 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 361100013401 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100013402 dimer interface [polypeptide binding]; other site 361100013403 putative CheW interface [polypeptide binding]; other site 361100013404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 361100013405 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 361100013406 Probable transposase; Region: OrfB_IS605; pfam01385 361100013407 Predicted transcriptional regulators [Transcription]; Region: COG1378 361100013408 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 361100013409 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 361100013410 C-terminal domain interface [polypeptide binding]; other site 361100013411 sugar binding site [chemical binding]; other site 361100013412 TQXA domain; Region: TQXA_dom; TIGR03934 361100013413 Cna protein B-type domain; Region: Cna_B; pfam05738 361100013414 Cna protein B-type domain; Region: Cna_B; pfam05738 361100013415 Cna protein B-type domain; Region: Cna_B; pfam05738 361100013416 Cna protein B-type domain; Region: Cna_B; pfam05738 361100013417 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 361100013418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100013419 putative substrate translocation pore; other site 361100013420 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 361100013421 Spore germination protein; Region: Spore_permease; cl17796 361100013422 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 361100013423 OxaA-like protein precursor; Validated; Region: PRK01622 361100013424 Uncharacterized conserved protein [Function unknown]; Region: COG1284 361100013425 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 361100013426 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 361100013427 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 361100013428 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100013429 hypothetical protein; Provisional; Region: PRK06758 361100013430 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 361100013431 active site 361100013432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100013433 non-specific DNA binding site [nucleotide binding]; other site 361100013434 salt bridge; other site 361100013435 sequence-specific DNA binding site [nucleotide binding]; other site 361100013436 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 361100013437 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 361100013438 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 361100013439 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 361100013440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 361100013441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100013442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100013443 active site 361100013444 phosphorylation site [posttranslational modification] 361100013445 intermolecular recognition site; other site 361100013446 dimerization interface [polypeptide binding]; other site 361100013447 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100013448 DNA binding site [nucleotide binding] 361100013449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100013450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100013451 dimer interface [polypeptide binding]; other site 361100013452 phosphorylation site [posttranslational modification] 361100013453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100013454 ATP binding site [chemical binding]; other site 361100013455 Mg2+ binding site [ion binding]; other site 361100013456 G-X-G motif; other site 361100013457 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100013458 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 361100013459 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 361100013460 active site 361100013461 HIGH motif; other site 361100013462 KMSKS motif; other site 361100013463 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 361100013464 tRNA binding surface [nucleotide binding]; other site 361100013465 anticodon binding site; other site 361100013466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100013467 S-adenosylmethionine binding site [chemical binding]; other site 361100013468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100013469 dimerization interface [polypeptide binding]; other site 361100013470 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 361100013471 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100013472 dimer interface [polypeptide binding]; other site 361100013473 putative CheW interface [polypeptide binding]; other site 361100013474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100013475 dimerization interface [polypeptide binding]; other site 361100013476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100013477 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 361100013478 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100013479 dimer interface [polypeptide binding]; other site 361100013480 putative CheW interface [polypeptide binding]; other site 361100013481 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 361100013482 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 361100013483 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 361100013484 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 361100013485 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 361100013486 active site 361100013487 Zn binding site [ion binding]; other site 361100013488 Pirin-related protein [General function prediction only]; Region: COG1741 361100013489 Pirin; Region: Pirin; pfam02678 361100013490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 361100013491 MarR family; Region: MarR_2; pfam12802 361100013492 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 361100013493 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 361100013494 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 361100013495 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 361100013496 TrkA-C domain; Region: TrkA_C; pfam02080 361100013497 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 361100013498 amino acid carrier protein; Region: agcS; TIGR00835 361100013499 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 361100013500 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 361100013501 dimerization interface [polypeptide binding]; other site 361100013502 DPS ferroxidase diiron center [ion binding]; other site 361100013503 ion pore; other site 361100013504 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 361100013505 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 361100013506 metal binding site [ion binding]; metal-binding site 361100013507 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 361100013508 Ferritin-like domain; Region: Ferritin; pfam00210 361100013509 ferroxidase diiron center [ion binding]; other site 361100013510 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 361100013511 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 361100013512 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 361100013513 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 361100013514 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 361100013515 Nucleoside recognition; Region: Gate; pfam07670 361100013516 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 361100013517 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 361100013518 amino acid carrier protein; Region: agcS; TIGR00835 361100013519 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 361100013520 amino acid carrier protein; Region: agcS; TIGR00835 361100013521 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 361100013522 NADH(P)-binding; Region: NAD_binding_10; pfam13460 361100013523 NAD binding site [chemical binding]; other site 361100013524 substrate binding site [chemical binding]; other site 361100013525 putative active site [active] 361100013526 Peptidase M60-like family; Region: M60-like; pfam13402 361100013527 TQXA domain; Region: TQXA_dom; TIGR03934 361100013528 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 361100013529 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 361100013530 active site 361100013531 catalytic tetrad [active] 361100013532 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 361100013533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100013534 putative substrate translocation pore; other site 361100013535 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100013536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100013537 dimerization interface [polypeptide binding]; other site 361100013538 putative DNA binding site [nucleotide binding]; other site 361100013539 putative Zn2+ binding site [ion binding]; other site 361100013540 Uncharacterized conserved protein [Function unknown]; Region: COG2427 361100013541 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 361100013542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100013543 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 361100013544 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 361100013545 active site 361100013546 HIGH motif; other site 361100013547 dimer interface [polypeptide binding]; other site 361100013548 KMSKS motif; other site 361100013549 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 361100013550 RNA binding surface [nucleotide binding]; other site 361100013551 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 361100013552 FAD binding domain; Region: FAD_binding_4; pfam01565 361100013553 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 361100013554 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 361100013555 SET domain; Region: SET; pfam00856 361100013556 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 361100013557 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 361100013558 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100013559 dimer interface [polypeptide binding]; other site 361100013560 putative CheW interface [polypeptide binding]; other site 361100013561 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 361100013562 putative phosphate binding site [ion binding]; other site 361100013563 camphor resistance protein CrcB; Provisional; Region: PRK14219 361100013564 camphor resistance protein CrcB; Provisional; Region: PRK14205 361100013565 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 361100013566 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 361100013567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100013568 H+ Antiporter protein; Region: 2A0121; TIGR00900 361100013569 putative substrate translocation pore; other site 361100013570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100013571 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 361100013572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100013573 Walker A/P-loop; other site 361100013574 ATP binding site [chemical binding]; other site 361100013575 Q-loop/lid; other site 361100013576 Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098 361100013577 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100013578 ABC transporter; Region: ABC_tran_2; pfam12848 361100013579 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100013580 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100013581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 361100013582 Coenzyme A binding pocket [chemical binding]; other site 361100013583 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 361100013584 Nuclease-related domain; Region: NERD; pfam08378 361100013585 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 361100013586 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 361100013587 Walker A/P-loop; other site 361100013588 ATP binding site [chemical binding]; other site 361100013589 Q-loop/lid; other site 361100013590 ABC transporter signature motif; other site 361100013591 Walker B; other site 361100013592 D-loop; other site 361100013593 H-loop/switch region; other site 361100013594 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100013595 ABC-ATPase subunit interface; other site 361100013596 dimer interface [polypeptide binding]; other site 361100013597 putative PBP binding regions; other site 361100013598 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 361100013599 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100013600 ABC-ATPase subunit interface; other site 361100013601 dimer interface [polypeptide binding]; other site 361100013602 putative PBP binding regions; other site 361100013603 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 361100013604 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 361100013605 putative ligand binding residues [chemical binding]; other site 361100013606 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100013607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100013608 active site 361100013609 phosphorylation site [posttranslational modification] 361100013610 intermolecular recognition site; other site 361100013611 dimerization interface [polypeptide binding]; other site 361100013612 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100013613 DNA binding site [nucleotide binding] 361100013614 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100013615 FtsX-like permease family; Region: FtsX; pfam02687 361100013616 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100013617 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 361100013618 Walker A/P-loop; other site 361100013619 ATP binding site [chemical binding]; other site 361100013620 Q-loop/lid; other site 361100013621 ABC transporter signature motif; other site 361100013622 Walker B; other site 361100013623 D-loop; other site 361100013624 H-loop/switch region; other site 361100013625 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 361100013626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 361100013627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100013628 dimerization interface [polypeptide binding]; other site 361100013629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100013630 dimer interface [polypeptide binding]; other site 361100013631 phosphorylation site [posttranslational modification] 361100013632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100013633 ATP binding site [chemical binding]; other site 361100013634 Mg2+ binding site [ion binding]; other site 361100013635 G-X-G motif; other site 361100013636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100013637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100013638 active site 361100013639 phosphorylation site [posttranslational modification] 361100013640 intermolecular recognition site; other site 361100013641 dimerization interface [polypeptide binding]; other site 361100013642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100013643 DNA binding site [nucleotide binding] 361100013644 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 361100013645 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 361100013646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100013647 S-adenosylmethionine binding site [chemical binding]; other site 361100013648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100013649 Walker A/P-loop; other site 361100013650 ATP binding site [chemical binding]; other site 361100013651 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 361100013652 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 361100013653 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 361100013654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 361100013655 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 361100013656 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100013657 dimerization interface [polypeptide binding]; other site 361100013658 putative DNA binding site [nucleotide binding]; other site 361100013659 putative Zn2+ binding site [ion binding]; other site 361100013660 hypothetical protein; Validated; Region: PRK08223 361100013661 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 361100013662 ATP binding site [chemical binding]; other site 361100013663 substrate interface [chemical binding]; other site 361100013664 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 361100013665 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 361100013666 substrate binding site [chemical binding]; other site 361100013667 active site 361100013668 cosubstrate binding site; other site 361100013669 catalytic site [active] 361100013670 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cd08370 361100013671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100013672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100013673 putative substrate translocation pore; other site 361100013674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100013675 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 361100013676 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 361100013677 tetramer interface [polypeptide binding]; other site 361100013678 active site 361100013679 Mg2+/Mn2+ binding site [ion binding]; other site 361100013680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100013681 putative DNA binding site [nucleotide binding]; other site 361100013682 putative Zn2+ binding site [ion binding]; other site 361100013683 Predicted membrane protein [Function unknown]; Region: COG2311 361100013684 Protein of unknown function (DUF418); Region: DUF418; cl12135 361100013685 Protein of unknown function (DUF418); Region: DUF418; pfam04235 361100013686 CAAX protease self-immunity; Region: Abi; pfam02517 361100013687 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 361100013688 SmpB-tmRNA interface; other site 361100013689 ribonuclease R; Region: RNase_R; TIGR02063 361100013690 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 361100013691 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 361100013692 RNB domain; Region: RNB; pfam00773 361100013693 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 361100013694 RNA binding site [nucleotide binding]; other site 361100013695 Esterase/lipase [General function prediction only]; Region: COG1647 361100013696 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 361100013697 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 361100013698 holin-like protein; Validated; Region: PRK01658 361100013699 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 361100013700 active site 361100013701 enolase; Provisional; Region: eno; PRK00077 361100013702 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 361100013703 dimer interface [polypeptide binding]; other site 361100013704 metal binding site [ion binding]; metal-binding site 361100013705 substrate binding pocket [chemical binding]; other site 361100013706 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 361100013707 phosphoglyceromutase; Provisional; Region: PRK05434 361100013708 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 361100013709 triosephosphate isomerase; Provisional; Region: PRK14565 361100013710 substrate binding site [chemical binding]; other site 361100013711 dimer interface [polypeptide binding]; other site 361100013712 catalytic triad [active] 361100013713 Phosphoglycerate kinase; Region: PGK; pfam00162 361100013714 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 361100013715 substrate binding site [chemical binding]; other site 361100013716 hinge regions; other site 361100013717 ADP binding site [chemical binding]; other site 361100013718 catalytic site [active] 361100013719 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 361100013720 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 361100013721 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 361100013722 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 361100013723 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 361100013724 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 361100013725 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 361100013726 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 361100013727 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 361100013728 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 361100013729 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 361100013730 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 361100013731 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 361100013732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100013733 Walker A/P-loop; other site 361100013734 ATP binding site [chemical binding]; other site 361100013735 Q-loop/lid; other site 361100013736 ABC transporter signature motif; other site 361100013737 Walker B; other site 361100013738 D-loop; other site 361100013739 H-loop/switch region; other site 361100013740 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 361100013741 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 361100013742 active site 361100013743 catalytic triad [active] 361100013744 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 361100013745 Peptidase C39 family; Region: Peptidase_C39; pfam03412 361100013746 putative active site [active] 361100013747 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100013748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100013749 Walker A/P-loop; other site 361100013750 ATP binding site [chemical binding]; other site 361100013751 Q-loop/lid; other site 361100013752 ABC transporter signature motif; other site 361100013753 Walker B; other site 361100013754 D-loop; other site 361100013755 H-loop/switch region; other site 361100013756 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100013757 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100013758 DNA binding residues [nucleotide binding] 361100013759 dimerization interface [polypeptide binding]; other site 361100013760 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 361100013761 substrate-Mg2+ binding site; other site 361100013762 aspartate-rich region 2; other site 361100013763 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 361100013764 protein binding site [polypeptide binding]; other site 361100013765 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 361100013766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100013767 ATP binding site [chemical binding]; other site 361100013768 Mg2+ binding site [ion binding]; other site 361100013769 G-X-G motif; other site 361100013770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100013771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100013772 active site 361100013773 phosphorylation site [posttranslational modification] 361100013774 intermolecular recognition site; other site 361100013775 dimerization interface [polypeptide binding]; other site 361100013776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100013777 DNA binding residues [nucleotide binding] 361100013778 dimerization interface [polypeptide binding]; other site 361100013779 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 361100013780 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 361100013781 active site 361100013782 zinc binding site [ion binding]; other site 361100013783 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 361100013784 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 361100013785 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 361100013786 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 361100013787 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 361100013788 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 361100013789 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 361100013790 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 361100013791 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 361100013792 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 361100013793 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 361100013794 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 361100013795 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 361100013796 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 361100013797 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 361100013798 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 361100013799 stage V sporulation protein AD; Provisional; Region: PRK12404 361100013800 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 361100013801 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 361100013802 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 361100013803 Predicted membrane protein [Function unknown]; Region: COG2323 361100013804 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 361100013805 Clp protease; Region: CLP_protease; pfam00574 361100013806 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 361100013807 oligomer interface [polypeptide binding]; other site 361100013808 active site residues [active] 361100013809 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 361100013810 dimerization domain swap beta strand [polypeptide binding]; other site 361100013811 regulatory protein interface [polypeptide binding]; other site 361100013812 active site 361100013813 regulatory phosphorylation site [posttranslational modification]; other site 361100013814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 361100013815 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 361100013816 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 361100013817 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 361100013818 phosphate binding site [ion binding]; other site 361100013819 putative substrate binding pocket [chemical binding]; other site 361100013820 dimer interface [polypeptide binding]; other site 361100013821 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 361100013822 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 361100013823 putative active site [active] 361100013824 nucleotide binding site [chemical binding]; other site 361100013825 nudix motif; other site 361100013826 putative metal binding site [ion binding]; other site 361100013827 Domain of unknown function (DUF368); Region: DUF368; pfam04018 361100013828 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 361100013829 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 361100013830 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 361100013831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100013832 binding surface 361100013833 TPR motif; other site 361100013834 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100013835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100013836 binding surface 361100013837 Tetratricopeptide repeat; Region: TPR_16; pfam13432 361100013838 TPR motif; other site 361100013839 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 361100013840 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 361100013841 trimer interface [polypeptide binding]; other site 361100013842 active site 361100013843 substrate binding site [chemical binding]; other site 361100013844 CoA binding site [chemical binding]; other site 361100013845 pyrophosphatase PpaX; Provisional; Region: PRK13288 361100013846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100013847 active site 361100013848 motif I; other site 361100013849 motif II; other site 361100013850 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 361100013851 HPr kinase/phosphorylase; Provisional; Region: PRK05428 361100013852 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 361100013853 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 361100013854 Hpr binding site; other site 361100013855 active site 361100013856 homohexamer subunit interaction site [polypeptide binding]; other site 361100013857 Predicted membrane protein [Function unknown]; Region: COG1950 361100013858 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 361100013859 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 361100013860 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 361100013861 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 361100013862 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 361100013863 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 361100013864 excinuclease ABC subunit B; Provisional; Region: PRK05298 361100013865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100013866 ATP binding site [chemical binding]; other site 361100013867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100013868 nucleotide binding region [chemical binding]; other site 361100013869 ATP-binding site [chemical binding]; other site 361100013870 Ultra-violet resistance protein B; Region: UvrB; pfam12344 361100013871 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 361100013872 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100013873 DNA binding residues [nucleotide binding] 361100013874 dimer interface [polypeptide binding]; other site 361100013875 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 361100013876 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100013877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100013878 non-specific DNA binding site [nucleotide binding]; other site 361100013879 salt bridge; other site 361100013880 sequence-specific DNA binding site [nucleotide binding]; other site 361100013881 Predicted membrane protein [Function unknown]; Region: COG2855 361100013882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100013883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100013884 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 361100013885 putative dimerization interface [polypeptide binding]; other site 361100013886 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 361100013887 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 361100013888 DNA binding residues [nucleotide binding] 361100013889 putative dimer interface [polypeptide binding]; other site 361100013890 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 361100013891 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 361100013892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100013893 H-loop/switch region; other site 361100013894 hypothetical protein; Provisional; Region: PRK12855 361100013895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 361100013896 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100013897 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 361100013898 Walker A/P-loop; other site 361100013899 ATP binding site [chemical binding]; other site 361100013900 Q-loop/lid; other site 361100013901 ABC transporter signature motif; other site 361100013902 Walker B; other site 361100013903 D-loop; other site 361100013904 H-loop/switch region; other site 361100013905 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 361100013906 protein binding site [polypeptide binding]; other site 361100013907 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 361100013908 C-terminal peptidase (prc); Region: prc; TIGR00225 361100013909 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 361100013910 protein binding site [polypeptide binding]; other site 361100013911 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 361100013912 Catalytic dyad [active] 361100013913 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 361100013914 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 361100013915 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 361100013916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100013917 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 361100013918 Walker A/P-loop; other site 361100013919 ATP binding site [chemical binding]; other site 361100013920 Q-loop/lid; other site 361100013921 ABC transporter signature motif; other site 361100013922 Walker B; other site 361100013923 D-loop; other site 361100013924 H-loop/switch region; other site 361100013925 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 361100013926 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 361100013927 peptide chain release factor 2; Provisional; Region: PRK06746 361100013928 This domain is found in peptide chain release factors; Region: PCRF; smart00937 361100013929 RF-1 domain; Region: RF-1; pfam00472 361100013930 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 361100013931 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 361100013932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 361100013933 nucleotide binding region [chemical binding]; other site 361100013934 ATP-binding site [chemical binding]; other site 361100013935 SEC-C motif; Region: SEC-C; pfam02810 361100013936 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 361100013937 30S subunit binding site; other site 361100013938 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 361100013939 DNA-binding site [nucleotide binding]; DNA binding site 361100013940 RNA-binding motif; other site 361100013941 comF family protein; Region: comF; TIGR00201 361100013942 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100013943 active site 361100013944 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 361100013945 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100013946 ATP binding site [chemical binding]; other site 361100013947 putative Mg++ binding site [ion binding]; other site 361100013948 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100013949 nucleotide binding region [chemical binding]; other site 361100013950 ATP-binding site [chemical binding]; other site 361100013951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 361100013952 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 361100013953 NlpC/P60 family; Region: NLPC_P60; pfam00877 361100013954 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100013955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100013956 dimerization interface [polypeptide binding]; other site 361100013957 putative DNA binding site [nucleotide binding]; other site 361100013958 putative Zn2+ binding site [ion binding]; other site 361100013959 EDD domain protein, DegV family; Region: DegV; TIGR00762 361100013960 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 361100013961 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 361100013962 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 361100013963 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 361100013964 Transcriptional regulator [Transcription]; Region: LytR; COG1316 361100013965 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 361100013966 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 361100013967 active site 361100013968 homodimer interface [polypeptide binding]; other site 361100013969 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 361100013970 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 361100013971 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 361100013972 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 361100013973 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 361100013974 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 361100013975 Mg++ binding site [ion binding]; other site 361100013976 putative catalytic motif [active] 361100013977 substrate binding site [chemical binding]; other site 361100013978 potential frameshift: common BLAST hit: gi|42784357|ref|NP_981604.1| polysaccharide deacetylase 361100013979 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 361100013980 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 361100013981 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 361100013982 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 361100013983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100013984 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 361100013985 Walker A motif; other site 361100013986 ATP binding site [chemical binding]; other site 361100013987 Walker B motif; other site 361100013988 arginine finger; other site 361100013989 Transcriptional antiterminator [Transcription]; Region: COG3933 361100013990 PRD domain; Region: PRD; pfam00874 361100013991 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 361100013992 active pocket/dimerization site; other site 361100013993 active site 361100013994 phosphorylation site [posttranslational modification] 361100013995 PRD domain; Region: PRD; pfam00874 361100013996 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 361100013997 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 361100013998 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 361100013999 Chromate transporter; Region: Chromate_transp; pfam02417 361100014000 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 361100014001 putative active site [active] 361100014002 YdjC motif; other site 361100014003 Mg binding site [ion binding]; other site 361100014004 putative homodimer interface [polypeptide binding]; other site 361100014005 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 361100014006 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 361100014007 NAD binding site [chemical binding]; other site 361100014008 sugar binding site [chemical binding]; other site 361100014009 divalent metal binding site [ion binding]; other site 361100014010 tetramer (dimer of dimers) interface [polypeptide binding]; other site 361100014011 dimer interface [polypeptide binding]; other site 361100014012 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 361100014013 active site 361100014014 methionine cluster; other site 361100014015 phosphorylation site [posttranslational modification] 361100014016 metal binding site [ion binding]; metal-binding site 361100014017 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 361100014018 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 361100014019 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 361100014020 active site 361100014021 P-loop; other site 361100014022 phosphorylation site [posttranslational modification] 361100014023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100014024 S-adenosylmethionine binding site [chemical binding]; other site 361100014025 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 361100014026 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 361100014027 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 361100014028 LytTr DNA-binding domain; Region: LytTR; smart00850 361100014029 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 361100014030 methionine cluster; other site 361100014031 active site 361100014032 phosphorylation site [posttranslational modification] 361100014033 metal binding site [ion binding]; metal-binding site 361100014034 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 361100014035 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 361100014036 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 361100014037 active site 361100014038 P-loop; other site 361100014039 phosphorylation site [posttranslational modification] 361100014040 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 361100014041 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 361100014042 Acyltransferase family; Region: Acyl_transf_3; pfam01757 361100014043 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 361100014044 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 361100014045 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 361100014046 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 361100014047 active site 361100014048 catalytic site [active] 361100014049 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014050 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014051 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 361100014052 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 361100014053 Domain of unknown function DUF11; Region: DUF11; pfam01345 361100014054 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 361100014055 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100014056 Domain of unknown function DUF11; Region: DUF11; cl17728 361100014057 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014058 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 361100014059 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 361100014060 Predicted membrane protein [Function unknown]; Region: COG1511 361100014061 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 361100014062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 361100014063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 361100014064 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 361100014065 putative dimerization interface [polypeptide binding]; other site 361100014066 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 361100014067 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 361100014068 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 361100014069 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 361100014070 transmembrane helices; other site 361100014071 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 361100014072 ThiC-associated domain; Region: ThiC-associated; pfam13667 361100014073 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 361100014074 L-lactate permease; Region: Lactate_perm; cl00701 361100014075 glycolate transporter; Provisional; Region: PRK09695 361100014076 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 361100014077 Uncharacterized conserved protein [Function unknown]; Region: COG3339 361100014078 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 361100014079 Sulfatase; Region: Sulfatase; pfam00884 361100014080 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 361100014081 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 361100014082 homodimer interface [polypeptide binding]; other site 361100014083 substrate-cofactor binding pocket; other site 361100014084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100014085 catalytic residue [active] 361100014086 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100014087 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100014088 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100014089 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100014090 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100014091 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 361100014092 NlpC/P60 family; Region: NLPC_P60; pfam00877 361100014093 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 361100014094 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 361100014095 Nucleoside recognition; Region: Gate; pfam07670 361100014096 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 361100014097 rod shape-determining protein MreC; Provisional; Region: PRK13922 361100014098 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 361100014099 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 361100014100 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 361100014101 DXD motif; other site 361100014102 BCCT family transporter; Region: BCCT; pfam02028 361100014103 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100014104 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100014105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 361100014106 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 361100014107 Predicted membrane protein [Function unknown]; Region: COG4640 361100014108 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 361100014109 Double zinc ribbon; Region: DZR; pfam12773 361100014110 Double zinc ribbon; Region: DZR; pfam12773 361100014111 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 361100014112 SNF2 Helicase protein; Region: DUF3670; pfam12419 361100014113 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 361100014114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 361100014115 ATP binding site [chemical binding]; other site 361100014116 putative Mg++ binding site [ion binding]; other site 361100014117 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 361100014118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100014119 nucleotide binding region [chemical binding]; other site 361100014120 ATP-binding site [chemical binding]; other site 361100014121 Predicted integral membrane protein [Function unknown]; Region: COG5652 361100014122 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 361100014123 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 361100014124 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 361100014125 ComK protein; Region: ComK; pfam06338 361100014126 RNA polymerase factor sigma-70; Validated; Region: PRK06759 361100014127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100014128 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 361100014129 DNA binding residues [nucleotide binding] 361100014130 Yip1 domain; Region: Yip1; cl17815 361100014131 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 361100014132 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 361100014133 FtsX-like permease family; Region: FtsX; pfam02687 361100014134 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 361100014135 Walker A/P-loop; other site 361100014136 ATP binding site [chemical binding]; other site 361100014137 ABC transporter; Region: ABC_tran; pfam00005 361100014138 Q-loop/lid; other site 361100014139 ABC transporter signature motif; other site 361100014140 Walker B; other site 361100014141 D-loop; other site 361100014142 H-loop/switch region; other site 361100014143 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 361100014144 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 361100014145 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 361100014146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100014147 putative substrate translocation pore; other site 361100014148 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 361100014149 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 361100014150 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 361100014151 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 361100014152 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100014153 dimerization interface [polypeptide binding]; other site 361100014154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100014155 dimer interface [polypeptide binding]; other site 361100014156 phosphorylation site [posttranslational modification] 361100014157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100014158 ATP binding site [chemical binding]; other site 361100014159 Mg2+ binding site [ion binding]; other site 361100014160 G-X-G motif; other site 361100014161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100014162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100014163 active site 361100014164 phosphorylation site [posttranslational modification] 361100014165 intermolecular recognition site; other site 361100014166 dimerization interface [polypeptide binding]; other site 361100014167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100014168 DNA binding site [nucleotide binding] 361100014169 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 361100014170 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 361100014171 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 361100014172 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 361100014173 active site 361100014174 P-loop; other site 361100014175 phosphorylation site [posttranslational modification] 361100014176 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 361100014177 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 361100014178 active site 361100014179 phosphorylation site [posttranslational modification] 361100014180 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 361100014181 HTH domain; Region: HTH_11; pfam08279 361100014182 HTH domain; Region: HTH_11; pfam08279 361100014183 PRD domain; Region: PRD; pfam00874 361100014184 PRD domain; Region: PRD; pfam00874 361100014185 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 361100014186 active site 361100014187 P-loop; other site 361100014188 phosphorylation site [posttranslational modification] 361100014189 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 361100014190 active site 361100014191 phosphorylation site [posttranslational modification] 361100014192 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 361100014193 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 361100014194 active site 361100014195 substrate binding site [chemical binding]; other site 361100014196 metal binding site [ion binding]; metal-binding site 361100014197 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 361100014198 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 361100014199 NAD binding site [chemical binding]; other site 361100014200 homodimer interface [polypeptide binding]; other site 361100014201 active site 361100014202 substrate binding site [chemical binding]; other site 361100014203 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 361100014204 UDP-glucose 4-epimerase; Region: PLN02240 361100014205 NAD binding site [chemical binding]; other site 361100014206 homodimer interface [polypeptide binding]; other site 361100014207 active site 361100014208 substrate binding site [chemical binding]; other site 361100014209 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 361100014210 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 361100014211 active site 361100014212 metal-binding site 361100014213 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100014214 EamA-like transporter family; Region: EamA; cl17759 361100014215 EamA-like transporter family; Region: EamA; cl17759 361100014216 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 361100014217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 361100014218 active site 361100014219 Phosphotransferase enzyme family; Region: APH; pfam01636 361100014220 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 361100014221 active site 361100014222 substrate binding site [chemical binding]; other site 361100014223 ATP binding site [chemical binding]; other site 361100014224 dimer interface [polypeptide binding]; other site 361100014225 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 361100014226 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 361100014227 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 361100014228 LicD family; Region: LicD; pfam04991 361100014229 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 361100014230 catalytic triad [active] 361100014231 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 361100014232 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 361100014233 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 361100014234 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 361100014235 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 361100014236 active site 361100014237 Cupin domain; Region: Cupin_2; cl17218 361100014238 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 361100014239 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 361100014240 putative ADP-binding pocket [chemical binding]; other site 361100014241 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 361100014242 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 361100014243 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 361100014244 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 361100014245 active site 361100014246 Bacterial sugar transferase; Region: Bac_transf; pfam02397 361100014247 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 361100014248 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 361100014249 active site 361100014250 tetramer interface; other site 361100014251 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 361100014252 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 361100014253 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 361100014254 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 361100014255 Chain length determinant protein; Region: Wzz; cl15801 361100014256 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 361100014257 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 361100014258 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 361100014259 rod shape-determining protein Mbl; Provisional; Region: PRK13928 361100014260 MreB and similar proteins; Region: MreB_like; cd10225 361100014261 nucleotide binding site [chemical binding]; other site 361100014262 Mg binding site [ion binding]; other site 361100014263 putative protofilament interaction site [polypeptide binding]; other site 361100014264 RodZ interaction site [polypeptide binding]; other site 361100014265 Stage III sporulation protein D; Region: SpoIIID; pfam12116 361100014266 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 361100014267 Peptidase family M23; Region: Peptidase_M23; pfam01551 361100014268 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 361100014269 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 361100014270 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100014271 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100014272 Walker A/P-loop; other site 361100014273 ATP binding site [chemical binding]; other site 361100014274 Q-loop/lid; other site 361100014275 ABC transporter signature motif; other site 361100014276 Walker B; other site 361100014277 D-loop; other site 361100014278 H-loop/switch region; other site 361100014279 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 361100014280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100014281 Walker A/P-loop; other site 361100014282 ATP binding site [chemical binding]; other site 361100014283 Q-loop/lid; other site 361100014284 ABC transporter signature motif; other site 361100014285 Walker B; other site 361100014286 D-loop; other site 361100014287 H-loop/switch region; other site 361100014288 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 361100014289 LytTr DNA-binding domain; Region: LytTR; pfam04397 361100014290 Stage II sporulation protein; Region: SpoIID; pfam08486 361100014291 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 361100014292 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 361100014293 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 361100014294 hinge; other site 361100014295 active site 361100014296 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 361100014297 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 361100014298 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 361100014299 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 361100014300 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 361100014301 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 361100014302 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 361100014303 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 361100014304 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 361100014305 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 361100014306 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 361100014307 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 361100014308 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 361100014309 4Fe-4S binding domain; Region: Fer4; cl02805 361100014310 4Fe-4S binding domain; Region: Fer4; pfam00037 361100014311 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 361100014312 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 361100014313 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 361100014314 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 361100014315 NADH dehydrogenase subunit C; Validated; Region: PRK07735 361100014316 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 361100014317 NADH dehydrogenase subunit B; Validated; Region: PRK06411 361100014318 NADH dehydrogenase subunit A; Validated; Region: PRK07756 361100014319 PAS domain S-box; Region: sensory_box; TIGR00229 361100014320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100014321 putative active site [active] 361100014322 heme pocket [chemical binding]; other site 361100014323 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 361100014324 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 361100014325 metal binding site [ion binding]; metal-binding site 361100014326 active site 361100014327 I-site; other site 361100014328 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 361100014329 Protein of unknown function (DUF975); Region: DUF975; cl10504 361100014330 Protein of unknown function (DUF975); Region: DUF975; cl10504 361100014331 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 361100014332 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 361100014333 gamma subunit interface [polypeptide binding]; other site 361100014334 epsilon subunit interface [polypeptide binding]; other site 361100014335 LBP interface [polypeptide binding]; other site 361100014336 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 361100014337 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 361100014338 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 361100014339 alpha subunit interaction interface [polypeptide binding]; other site 361100014340 Walker A motif; other site 361100014341 ATP binding site [chemical binding]; other site 361100014342 Walker B motif; other site 361100014343 inhibitor binding site; inhibition site 361100014344 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 361100014345 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 361100014346 core domain interface [polypeptide binding]; other site 361100014347 delta subunit interface [polypeptide binding]; other site 361100014348 epsilon subunit interface [polypeptide binding]; other site 361100014349 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 361100014350 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 361100014351 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 361100014352 beta subunit interaction interface [polypeptide binding]; other site 361100014353 Walker A motif; other site 361100014354 ATP binding site [chemical binding]; other site 361100014355 Walker B motif; other site 361100014356 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 361100014357 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 361100014358 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 361100014359 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 361100014360 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 361100014361 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 361100014362 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 361100014363 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 361100014364 ATP synthase I chain; Region: ATP_synt_I; pfam03899 361100014365 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 361100014366 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 361100014367 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 361100014368 active site 361100014369 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 361100014370 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 361100014371 dimer interface [polypeptide binding]; other site 361100014372 active site 361100014373 glycine-pyridoxal phosphate binding site [chemical binding]; other site 361100014374 folate binding site [chemical binding]; other site 361100014375 hypothetical protein; Provisional; Region: PRK13690 361100014376 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 361100014377 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 361100014378 Low molecular weight phosphatase family; Region: LMWPc; cd00115 361100014379 active site 361100014380 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 361100014381 HPr interaction site; other site 361100014382 glycerol kinase (GK) interaction site [polypeptide binding]; other site 361100014383 active site 361100014384 phosphorylation site [posttranslational modification] 361100014385 Predicted membrane protein [Function unknown]; Region: COG2259 361100014386 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 361100014387 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 361100014388 Predicted membrane protein [Function unknown]; Region: COG1971 361100014389 Domain of unknown function DUF; Region: DUF204; pfam02659 361100014390 Domain of unknown function DUF; Region: DUF204; pfam02659 361100014391 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 361100014392 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 361100014393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 361100014394 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 361100014395 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 361100014396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100014397 S-adenosylmethionine binding site [chemical binding]; other site 361100014398 peptide chain release factor 1; Validated; Region: prfA; PRK00591 361100014399 This domain is found in peptide chain release factors; Region: PCRF; smart00937 361100014400 RF-1 domain; Region: RF-1; pfam00472 361100014401 thymidine kinase; Provisional; Region: PRK04296 361100014402 transcription termination factor Rho; Provisional; Region: rho; PRK09376 361100014403 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 361100014404 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 361100014405 RNA binding site [nucleotide binding]; other site 361100014406 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 361100014407 multimer interface [polypeptide binding]; other site 361100014408 Walker A motif; other site 361100014409 ATP binding site [chemical binding]; other site 361100014410 Walker B motif; other site 361100014411 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 361100014412 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 361100014413 putative active site [active] 361100014414 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 361100014415 active site 361100014416 hinge; other site 361100014417 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 361100014418 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 361100014419 intersubunit interface [polypeptide binding]; other site 361100014420 active site 361100014421 zinc binding site [ion binding]; other site 361100014422 Na+ binding site [ion binding]; other site 361100014423 Response regulator receiver domain; Region: Response_reg; pfam00072 361100014424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100014425 active site 361100014426 phosphorylation site [posttranslational modification] 361100014427 intermolecular recognition site; other site 361100014428 dimerization interface [polypeptide binding]; other site 361100014429 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 361100014430 CTP synthetase; Validated; Region: pyrG; PRK05380 361100014431 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 361100014432 Catalytic site [active] 361100014433 active site 361100014434 UTP binding site [chemical binding]; other site 361100014435 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 361100014436 active site 361100014437 putative oxyanion hole; other site 361100014438 catalytic triad [active] 361100014439 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 361100014440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100014441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100014442 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 361100014443 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 361100014444 FAD binding site [chemical binding]; other site 361100014445 homotetramer interface [polypeptide binding]; other site 361100014446 substrate binding pocket [chemical binding]; other site 361100014447 catalytic base [active] 361100014448 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 361100014449 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 361100014450 FAD binding site [chemical binding]; other site 361100014451 homotetramer interface [polypeptide binding]; other site 361100014452 substrate binding pocket [chemical binding]; other site 361100014453 catalytic base [active] 361100014454 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 361100014455 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 361100014456 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 361100014457 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 361100014458 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 361100014459 dimer interface [polypeptide binding]; other site 361100014460 active site 361100014461 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 361100014462 4Fe-4S binding domain; Region: Fer4; cl02805 361100014463 Cysteine-rich domain; Region: CCG; pfam02754 361100014464 Cysteine-rich domain; Region: CCG; pfam02754 361100014465 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 361100014466 PLD-like domain; Region: PLDc_2; pfam13091 361100014467 putative active site [active] 361100014468 catalytic site [active] 361100014469 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 361100014470 PLD-like domain; Region: PLDc_2; pfam13091 361100014471 putative active site [active] 361100014472 catalytic site [active] 361100014473 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 361100014474 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 361100014475 PAS domain S-box; Region: sensory_box; TIGR00229 361100014476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100014477 putative active site [active] 361100014478 heme pocket [chemical binding]; other site 361100014479 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 361100014480 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 361100014481 metal binding site [ion binding]; metal-binding site 361100014482 active site 361100014483 I-site; other site 361100014484 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 361100014485 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 361100014486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100014487 non-specific DNA binding site [nucleotide binding]; other site 361100014488 salt bridge; other site 361100014489 sequence-specific DNA binding site [nucleotide binding]; other site 361100014490 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100014491 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 361100014492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100014493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100014494 active site 361100014495 phosphorylation site [posttranslational modification] 361100014496 intermolecular recognition site; other site 361100014497 dimerization interface [polypeptide binding]; other site 361100014498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100014499 DNA binding residues [nucleotide binding] 361100014500 dimerization interface [polypeptide binding]; other site 361100014501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 361100014502 Histidine kinase; Region: HisKA_3; pfam07730 361100014503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100014504 ATP binding site [chemical binding]; other site 361100014505 Mg2+ binding site [ion binding]; other site 361100014506 G-X-G motif; other site 361100014507 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 361100014508 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 361100014509 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100014510 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100014511 Walker A/P-loop; other site 361100014512 ATP binding site [chemical binding]; other site 361100014513 Q-loop/lid; other site 361100014514 ABC transporter signature motif; other site 361100014515 Walker B; other site 361100014516 D-loop; other site 361100014517 H-loop/switch region; other site 361100014518 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 361100014519 active site 361100014520 MARCKS family; Region: MARCKS; pfam02063 361100014521 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 361100014522 Collagen binding domain; Region: Collagen_bind; pfam05737 361100014523 Collagen binding domain; Region: Collagen_bind; pfam05737 361100014524 Collagen binding domain; Region: Collagen_bind; pfam05737 361100014525 Collagen binding domain; Region: Collagen_bind; pfam05737 361100014526 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014527 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014528 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014529 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014530 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014531 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014532 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014533 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 361100014534 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014535 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014536 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014537 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014538 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 361100014539 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014540 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014541 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014542 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014543 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014544 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014545 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014546 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 361100014547 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014548 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014549 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014550 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014551 Cna protein B-type domain; Region: Cna_B; pfam05738 361100014552 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 361100014553 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 361100014554 PA/protease or protease-like domain interface [polypeptide binding]; other site 361100014555 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 361100014556 Peptidase family M28; Region: Peptidase_M28; pfam04389 361100014557 metal binding site [ion binding]; metal-binding site 361100014558 RNA polymerase sigma factor; Provisional; Region: PRK12522 361100014559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 361100014560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100014561 DNA binding residues [nucleotide binding] 361100014562 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 361100014563 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 361100014564 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 361100014565 active site 361100014566 HIGH motif; other site 361100014567 KMSK motif region; other site 361100014568 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 361100014569 tRNA binding surface [nucleotide binding]; other site 361100014570 anticodon binding site; other site 361100014571 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 361100014572 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 361100014573 putative dimer interface [polypeptide binding]; other site 361100014574 catalytic triad [active] 361100014575 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 361100014576 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 361100014577 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 361100014578 agmatinase; Region: agmatinase; TIGR01230 361100014579 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 361100014580 putative active site [active] 361100014581 Mn binding site [ion binding]; other site 361100014582 spermidine synthase; Provisional; Region: PRK00811 361100014583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100014584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100014585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100014586 putative substrate translocation pore; other site 361100014587 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 361100014588 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 361100014589 DNA binding residues [nucleotide binding] 361100014590 putative dimer interface [polypeptide binding]; other site 361100014591 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 361100014592 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 361100014593 active site 361100014594 catalytic site [active] 361100014595 metal binding site [ion binding]; metal-binding site 361100014596 dimer interface [polypeptide binding]; other site 361100014597 Transglycosylase; Region: Transgly; pfam00912 361100014598 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 361100014599 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 361100014600 YwhD family; Region: YwhD; pfam08741 361100014601 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 361100014602 Peptidase family M50; Region: Peptidase_M50; pfam02163 361100014603 active site 361100014604 putative substrate binding region [chemical binding]; other site 361100014605 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 361100014606 active site 1 [active] 361100014607 dimer interface [polypeptide binding]; other site 361100014608 hexamer interface [polypeptide binding]; other site 361100014609 active site 2 [active] 361100014610 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 361100014611 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 361100014612 Zn2+ binding site [ion binding]; other site 361100014613 Mg2+ binding site [ion binding]; other site 361100014614 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 361100014615 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 361100014616 intersubunit interface [polypeptide binding]; other site 361100014617 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 361100014618 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 361100014619 Walker A/P-loop; other site 361100014620 ATP binding site [chemical binding]; other site 361100014621 Q-loop/lid; other site 361100014622 ABC transporter signature motif; other site 361100014623 Walker B; other site 361100014624 D-loop; other site 361100014625 H-loop/switch region; other site 361100014626 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 361100014627 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100014628 ABC-ATPase subunit interface; other site 361100014629 dimer interface [polypeptide binding]; other site 361100014630 putative PBP binding regions; other site 361100014631 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 361100014632 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 361100014633 ABC-ATPase subunit interface; other site 361100014634 dimer interface [polypeptide binding]; other site 361100014635 putative PBP binding regions; other site 361100014636 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 361100014637 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 361100014638 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 361100014639 hypothetical protein; Provisional; Region: PRK12473 361100014640 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 361100014641 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 361100014642 putative heme peroxidase; Provisional; Region: PRK12276 361100014643 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 361100014644 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 361100014645 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 361100014646 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 361100014647 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 361100014648 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 361100014649 Ion channel; Region: Ion_trans_2; pfam07885 361100014650 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 361100014651 TrkA-N domain; Region: TrkA_N; pfam02254 361100014652 TrkA-C domain; Region: TrkA_C; pfam02080 361100014653 putative uracil/xanthine transporter; Provisional; Region: PRK11412 361100014654 potential frameshift: common BLAST hit: gi|42784570|ref|NP_981817.1| HAD superfamily hydrolase 361100014655 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 361100014656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100014657 motif II; other site 361100014658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100014659 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 361100014660 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 361100014661 ligand binding site [chemical binding]; other site 361100014662 active site 361100014663 UGI interface [polypeptide binding]; other site 361100014664 catalytic site [active] 361100014665 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 361100014666 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 361100014667 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 361100014668 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100014669 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 361100014670 Walker A/P-loop; other site 361100014671 ATP binding site [chemical binding]; other site 361100014672 Q-loop/lid; other site 361100014673 ABC transporter signature motif; other site 361100014674 Walker B; other site 361100014675 D-loop; other site 361100014676 H-loop/switch region; other site 361100014677 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 361100014678 active site 361100014679 catalytic triad [active] 361100014680 oxyanion hole [active] 361100014681 Transcriptional regulators [Transcription]; Region: PurR; COG1609 361100014682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 361100014683 DNA binding site [nucleotide binding] 361100014684 domain linker motif; other site 361100014685 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 361100014686 putative dimerization interface [polypeptide binding]; other site 361100014687 putative ligand binding site [chemical binding]; other site 361100014688 Predicted membrane protein [Function unknown]; Region: COG2364 361100014689 homoserine dehydrogenase; Provisional; Region: PRK06349 361100014690 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 361100014691 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 361100014692 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 361100014693 Homoserine O-succinyltransferase; Region: HTS; pfam04204 361100014694 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 361100014695 proposed active site lysine [active] 361100014696 conserved cys residue [active] 361100014697 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 361100014698 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 361100014699 homodimer interface [polypeptide binding]; other site 361100014700 substrate-cofactor binding pocket; other site 361100014701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 361100014702 catalytic residue [active] 361100014703 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 361100014704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100014705 active site 361100014706 motif I; other site 361100014707 motif II; other site 361100014708 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 361100014709 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 361100014710 ligand binding site [chemical binding]; other site 361100014711 flexible hinge region; other site 361100014712 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 361100014713 azoreductase; Provisional; Region: PRK13556 361100014714 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 361100014715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100014716 active site 361100014717 phosphorylation site [posttranslational modification] 361100014718 intermolecular recognition site; other site 361100014719 dimerization interface [polypeptide binding]; other site 361100014720 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 361100014721 DNA binding residues [nucleotide binding] 361100014722 dimerization interface [polypeptide binding]; other site 361100014723 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 361100014724 GAF domain; Region: GAF; pfam01590 361100014725 GAF domain; Region: GAF_3; pfam13492 361100014726 GAF domain; Region: GAF_2; pfam13185 361100014727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 361100014728 Histidine kinase; Region: HisKA_3; pfam07730 361100014729 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 361100014730 ATP binding site [chemical binding]; other site 361100014731 Mg2+ binding site [ion binding]; other site 361100014732 G-X-G motif; other site 361100014733 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 361100014734 dimer interface [polypeptide binding]; other site 361100014735 substrate binding site [chemical binding]; other site 361100014736 ATP binding site [chemical binding]; other site 361100014737 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 361100014738 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 361100014739 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 361100014740 metal binding site [ion binding]; metal-binding site 361100014741 active site 361100014742 I-site; other site 361100014743 Protein of unknown function (DUF466); Region: DUF466; pfam04328 361100014744 carbon starvation protein A; Provisional; Region: PRK15015 361100014745 Carbon starvation protein CstA; Region: CstA; pfam02554 361100014746 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 361100014747 two-component response regulator; Provisional; Region: PRK14084 361100014748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100014749 active site 361100014750 phosphorylation site [posttranslational modification] 361100014751 intermolecular recognition site; other site 361100014752 dimerization interface [polypeptide binding]; other site 361100014753 LytTr DNA-binding domain; Region: LytTR; pfam04397 361100014754 benzoate transport; Region: 2A0115; TIGR00895 361100014755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100014756 putative substrate translocation pore; other site 361100014757 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 361100014758 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 361100014759 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 361100014760 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 361100014761 Predicted membrane protein [Function unknown]; Region: COG2860 361100014762 UPF0126 domain; Region: UPF0126; pfam03458 361100014763 UPF0126 domain; Region: UPF0126; pfam03458 361100014764 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 361100014765 heme-binding site [chemical binding]; other site 361100014766 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 361100014767 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100014768 dimer interface [polypeptide binding]; other site 361100014769 putative CheW interface [polypeptide binding]; other site 361100014770 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 361100014771 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 361100014772 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 361100014773 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 361100014774 Ligand binding site; other site 361100014775 Putative Catalytic site; other site 361100014776 DXD motif; other site 361100014777 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 361100014778 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 361100014779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 361100014780 active site 361100014781 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 361100014782 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 361100014783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100014784 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 361100014785 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100014786 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100014787 ABC transporter; Region: ABC_tran_2; pfam12848 361100014788 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 361100014789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 361100014790 Integrase core domain; Region: rve; pfam00665 361100014791 transposase/IS protein; Provisional; Region: PRK09183 361100014792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100014793 Walker A motif; other site 361100014794 ATP binding site [chemical binding]; other site 361100014795 Walker B motif; other site 361100014796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100014797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100014798 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 361100014799 Protein export membrane protein; Region: SecD_SecF; cl14618 361100014800 methionine sulfoxide reductase A; Provisional; Region: PRK14054 361100014801 methionine sulfoxide reductase B; Provisional; Region: PRK00222 361100014802 SelR domain; Region: SelR; pfam01641 361100014803 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 361100014804 antiholin-like protein LrgB; Provisional; Region: PRK04288 361100014805 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 361100014806 two-component response regulator; Provisional; Region: PRK14084 361100014807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100014808 active site 361100014809 phosphorylation site [posttranslational modification] 361100014810 intermolecular recognition site; other site 361100014811 dimerization interface [polypeptide binding]; other site 361100014812 LytTr DNA-binding domain; Region: LytTR; pfam04397 361100014813 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 361100014814 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 361100014815 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 361100014816 Histidine kinase; Region: His_kinase; pfam06580 361100014817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100014818 ATP binding site [chemical binding]; other site 361100014819 Mg2+ binding site [ion binding]; other site 361100014820 G-X-G motif; other site 361100014821 potential frameshift: common BLAST hit: gi|52145250|ref|YP_086707.1| major facilitator transporter 361100014822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100014823 putative substrate translocation pore; other site 361100014824 benzoate transport; Region: 2A0115; TIGR00895 361100014825 BCCT family transporter; Region: BCCT; pfam02028 361100014826 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 361100014827 active site 361100014828 dimer interface [polypeptide binding]; other site 361100014829 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 361100014830 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 361100014831 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 361100014832 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 361100014833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 361100014834 NAD(P) binding site [chemical binding]; other site 361100014835 active site 361100014836 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 361100014837 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 361100014838 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 361100014839 GAF domain; Region: GAF_3; pfam13492 361100014840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100014841 binding surface 361100014842 TPR motif; other site 361100014843 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 361100014844 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 361100014845 NodB motif; other site 361100014846 putative active site [active] 361100014847 putative catalytic site [active] 361100014848 putative Zn binding site [ion binding]; other site 361100014849 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 361100014850 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 361100014851 Predicted membrane protein [Function unknown]; Region: COG4267 361100014852 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 361100014853 UDP-glucose 4-epimerase; Region: PLN02240 361100014854 NAD binding site [chemical binding]; other site 361100014855 homodimer interface [polypeptide binding]; other site 361100014856 active site 361100014857 substrate binding site [chemical binding]; other site 361100014858 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 361100014859 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 361100014860 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 361100014861 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 361100014862 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 361100014863 ATP binding site [chemical binding]; other site 361100014864 Mg++ binding site [ion binding]; other site 361100014865 motif III; other site 361100014866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 361100014867 nucleotide binding region [chemical binding]; other site 361100014868 ATP-binding site [chemical binding]; other site 361100014869 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 361100014870 RNA binding site [nucleotide binding]; other site 361100014871 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 361100014872 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 361100014873 active site 361100014874 oligoendopeptidase F; Region: pepF; TIGR00181 361100014875 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 361100014876 active site 361100014877 Zn binding site [ion binding]; other site 361100014878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100014879 FeS/SAM binding site; other site 361100014880 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 361100014881 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 361100014882 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 361100014883 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 361100014884 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 361100014885 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 361100014886 protein binding site [polypeptide binding]; other site 361100014887 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 361100014888 YycH protein; Region: YycI; pfam09648 361100014889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 361100014890 YycH protein; Region: YycH; pfam07435 361100014891 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 361100014892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 361100014893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 361100014894 dimerization interface [polypeptide binding]; other site 361100014895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100014896 putative active site [active] 361100014897 heme pocket [chemical binding]; other site 361100014898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 361100014899 dimer interface [polypeptide binding]; other site 361100014900 phosphorylation site [posttranslational modification] 361100014901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 361100014902 ATP binding site [chemical binding]; other site 361100014903 Mg2+ binding site [ion binding]; other site 361100014904 G-X-G motif; other site 361100014905 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 361100014906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 361100014907 active site 361100014908 phosphorylation site [posttranslational modification] 361100014909 intermolecular recognition site; other site 361100014910 dimerization interface [polypeptide binding]; other site 361100014911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 361100014912 DNA binding site [nucleotide binding] 361100014913 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 361100014914 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 361100014915 GDP-binding site [chemical binding]; other site 361100014916 ACT binding site; other site 361100014917 IMP binding site; other site 361100014918 replicative DNA helicase; Provisional; Region: PRK05748 361100014919 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 361100014920 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 361100014921 Walker A motif; other site 361100014922 ATP binding site [chemical binding]; other site 361100014923 Walker B motif; other site 361100014924 DNA binding loops [nucleotide binding] 361100014925 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 361100014926 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 361100014927 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 361100014928 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 361100014929 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 361100014930 DHH family; Region: DHH; pfam01368 361100014931 DHHA1 domain; Region: DHHA1; pfam02272 361100014932 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 361100014933 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 361100014934 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 361100014935 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 361100014936 dimer interface [polypeptide binding]; other site 361100014937 ssDNA binding site [nucleotide binding]; other site 361100014938 tetramer (dimer of dimers) interface [polypeptide binding]; other site 361100014939 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 361100014940 GTP-binding protein YchF; Reviewed; Region: PRK09601 361100014941 YchF GTPase; Region: YchF; cd01900 361100014942 G1 box; other site 361100014943 GTP/Mg2+ binding site [chemical binding]; other site 361100014944 Switch I region; other site 361100014945 G2 box; other site 361100014946 Switch II region; other site 361100014947 G3 box; other site 361100014948 G4 box; other site 361100014949 G5 box; other site 361100014950 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 361100014951 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 361100014952 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 361100014953 Mechanosensitive ion channel; Region: MS_channel; pfam00924 361100014954 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 361100014955 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 361100014956 ParB-like nuclease domain; Region: ParB; smart00470 361100014957 KorB domain; Region: KorB; pfam08535 361100014958 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 361100014959 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 361100014960 P-loop; other site 361100014961 Magnesium ion binding site [ion binding]; other site 361100014962 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 361100014963 Magnesium ion binding site [ion binding]; other site 361100014964 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 361100014965 ParB-like nuclease domain; Region: ParBc; pfam02195 361100014966 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 361100014967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100014968 S-adenosylmethionine binding site [chemical binding]; other site 361100014969 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 361100014970 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 361100014971 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 361100014972 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 361100014973 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 361100014974 trmE is a tRNA modification GTPase; Region: trmE; cd04164 361100014975 G1 box; other site 361100014976 GTP/Mg2+ binding site [chemical binding]; other site 361100014977 Switch I region; other site 361100014978 G2 box; other site 361100014979 Switch II region; other site 361100014980 G3 box; other site 361100014981 G4 box; other site 361100014982 G5 box; other site 361100014983 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 361100014984 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 361100014985 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 361100014986 G-X-X-G motif; other site 361100014987 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 361100014988 RxxxH motif; other site 361100014989 OxaA-like protein precursor; Validated; Region: PRK02944 361100014990 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 361100014991 ribonuclease P; Reviewed; Region: rnpA; PRK00499 361100014992 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 361100014993 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 361100014994 active site 361100014995 catalytic site [active] 361100014996 substrate binding site [chemical binding]; other site 361100014997 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 361100014998 plasmid segregation protein ParM; Provisional; Region: PRK13917 361100014999 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 361100015000 Mg binding site [ion binding]; other site 361100015001 nucleotide binding site [chemical binding]; other site 361100015002 putative protofilament interface [polypeptide binding]; other site 361100015003 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 361100015004 Helix-turn-helix domain; Region: HTH_17; pfam12728 361100015005 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 361100015006 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 361100015007 amidase catalytic site [active] 361100015008 Zn binding residues [ion binding]; other site 361100015009 substrate binding site [chemical binding]; other site 361100015010 Bacterial SH3 domain; Region: SH3_3; pfam08239 361100015011 Holin family; Region: Phage_holin_4; cl01989 361100015012 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 361100015013 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 361100015014 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 361100015015 Phage-related protein [Function unknown]; Region: COG5412 361100015016 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 361100015017 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 361100015018 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 361100015019 Phage capsid family; Region: Phage_capsid; pfam05065 361100015020 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 361100015021 Phage-related protein [Function unknown]; Region: COG4695; cl01923 361100015022 Phage terminase large subunit; Region: Terminase_3; cl12054 361100015023 Terminase-like family; Region: Terminase_6; pfam03237 361100015024 Phage terminase small subunit; Region: Phage_terminase; pfam10668 361100015025 Uncharacterized conserved protein [Function unknown]; Region: COG5484 361100015026 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100015027 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 361100015028 catalytic residues [active] 361100015029 catalytic nucleophile [active] 361100015030 Presynaptic Site I dimer interface [polypeptide binding]; other site 361100015031 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 361100015032 Synaptic Flat tetramer interface [polypeptide binding]; other site 361100015033 Synaptic Site I dimer interface [polypeptide binding]; other site 361100015034 DNA binding site [nucleotide binding] 361100015035 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 361100015036 DNA-binding interface [nucleotide binding]; DNA binding site 361100015037 Helix-turn-helix domain; Region: HTH_17; cl17695 361100015038 positive control sigma-like factor; Validated; Region: PRK06930 361100015039 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 361100015040 DNA binding residues [nucleotide binding] 361100015041 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 361100015042 Recombination protein U; Region: RecU; pfam03838 361100015043 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 361100015044 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 361100015045 dUTPase; Region: dUTPase_2; pfam08761 361100015046 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 361100015047 active site 361100015048 homodimer interface [polypeptide binding]; other site 361100015049 metal binding site [ion binding]; metal-binding site 361100015050 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 361100015051 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 361100015052 ORF6C domain; Region: ORF6C; pfam10552 361100015053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100015054 non-specific DNA binding site [nucleotide binding]; other site 361100015055 salt bridge; other site 361100015056 sequence-specific DNA binding site [nucleotide binding]; other site 361100015057 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100015058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100015059 non-specific DNA binding site [nucleotide binding]; other site 361100015060 salt bridge; other site 361100015061 sequence-specific DNA binding site [nucleotide binding]; other site 361100015062 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 361100015063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100015064 non-specific DNA binding site [nucleotide binding]; other site 361100015065 salt bridge; other site 361100015066 sequence-specific DNA binding site [nucleotide binding]; other site 361100015067 DNA polymerase III subunit beta; Validated; Region: PRK05643 361100015068 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 361100015069 putative DNA binding surface [nucleotide binding]; other site 361100015070 dimer interface [polypeptide binding]; other site 361100015071 beta-clamp/clamp loader binding surface; other site 361100015072 beta-clamp/translesion DNA polymerase binding surface; other site 361100015073 Prokaryotic E2 family D; Region: Prok-E2_D; pfam14460 361100015074 PRTRC system protein A; Region: PRTRC_A; TIGR03735 361100015075 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 361100015076 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 361100015077 ATP binding site [chemical binding]; other site 361100015078 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 361100015079 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 361100015080 putative active site [active] 361100015081 putative NTP binding site [chemical binding]; other site 361100015082 putative nucleic acid binding site [nucleotide binding]; other site 361100015083 Type II intron maturase; Region: Intron_maturas2; pfam01348 361100015084 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 361100015085 active site 361100015086 NTP binding site [chemical binding]; other site 361100015087 metal binding triad [ion binding]; metal-binding site 361100015088 antibiotic binding site [chemical binding]; other site 361100015089 HEPN domain; Region: HEPN; pfam05168 361100015090 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 361100015091 Active Sites [active] 361100015092 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 361100015093 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 361100015094 active site 361100015095 catalytic residues [active] 361100015096 DNA binding site [nucleotide binding] 361100015097 Int/Topo IB signature motif; other site 361100015098 Helix-turn-helix domain; Region: HTH_38; pfam13936 361100015099 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 361100015100 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 361100015101 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 361100015102 putative active site [active] 361100015103 putative catalytic triad [active] 361100015104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 361100015105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 361100015106 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 361100015107 active site 361100015108 NTP binding site [chemical binding]; other site 361100015109 metal binding triad [ion binding]; metal-binding site 361100015110 antibiotic binding site [chemical binding]; other site 361100015111 Protein of unknown function DUF86; Region: DUF86; pfam01934 361100015112 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 361100015113 Cytochrome P450; Region: p450; cl12078 361100015114 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 361100015115 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 361100015116 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 361100015117 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 361100015118 homodimer interface [polypeptide binding]; other site 361100015119 active site 361100015120 TDP-binding site; other site 361100015121 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 361100015122 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 361100015123 putative transposase OrfB; Reviewed; Region: PHA02517 361100015124 HTH-like domain; Region: HTH_21; pfam13276 361100015125 Integrase core domain; Region: rve; pfam00665 361100015126 Integrase core domain; Region: rve_2; pfam13333 361100015127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 361100015128 Transposase; Region: HTH_Tnp_1; pfam01527 361100015129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 361100015130 Transposase; Region: HTH_Tnp_1; pfam01527 361100015131 putative transposase OrfB; Reviewed; Region: PHA02517 361100015132 HTH-like domain; Region: HTH_21; pfam13276 361100015133 Integrase core domain; Region: rve; pfam00665 361100015134 Integrase core domain; Region: rve_2; pfam13333 361100015135 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 361100015136 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 361100015137 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 361100015138 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 361100015139 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 361100015140 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 361100015141 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100015142 putative DNA binding site [nucleotide binding]; other site 361100015143 putative Zn2+ binding site [ion binding]; other site 361100015144 AsnC family; Region: AsnC_trans_reg; pfam01037 361100015145 Uncharacterized conserved protein [Function unknown]; Region: COG2128 361100015146 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 361100015147 Electron transfer DM13; Region: DM13; cl02735 361100015148 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 361100015149 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 361100015150 Predicted membrane protein [Function unknown]; Region: COG2323 361100015151 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 361100015152 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 361100015153 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 361100015154 putative active site [active] 361100015155 catalytic site [active] 361100015156 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 361100015157 putative active site [active] 361100015158 catalytic site [active] 361100015159 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100015160 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100015161 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100015162 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 361100015163 catalytic residues [active] 361100015164 catalytic nucleophile [active] 361100015165 Presynaptic Site I dimer interface [polypeptide binding]; other site 361100015166 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 361100015167 Synaptic Flat tetramer interface [polypeptide binding]; other site 361100015168 Synaptic Site I dimer interface [polypeptide binding]; other site 361100015169 DNA binding site [nucleotide binding] 361100015170 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 361100015171 DNA-binding interface [nucleotide binding]; DNA binding site 361100015172 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 361100015173 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 361100015174 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 361100015175 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 361100015176 active site 361100015177 Int/Topo IB signature motif; other site 361100015178 DNA binding site [nucleotide binding] 361100015179 Helix-turn-helix domain; Region: HTH_17; pfam12728 361100015180 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 361100015181 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 361100015182 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 361100015183 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 361100015184 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100015185 Spore germination protein; Region: Spore_permease; cl17796 361100015186 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100015187 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100015188 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 361100015189 multiple promoter invertase; Provisional; Region: mpi; PRK13413 361100015190 catalytic residues [active] 361100015191 catalytic nucleophile [active] 361100015192 Presynaptic Site I dimer interface [polypeptide binding]; other site 361100015193 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 361100015194 Synaptic Flat tetramer interface [polypeptide binding]; other site 361100015195 Synaptic Site I dimer interface [polypeptide binding]; other site 361100015196 DNA binding site [nucleotide binding] 361100015197 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 361100015198 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 361100015199 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100015200 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100015201 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015202 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015203 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015204 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015205 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015206 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015207 Domain of unknown function DUF11; Region: DUF11; cl17728 361100015208 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015209 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015210 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015211 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015212 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015213 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015214 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015215 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015216 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015217 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015218 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015219 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015220 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015221 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015222 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015223 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015224 Domain of unknown function DUF11; Region: DUF11; cl17728 361100015225 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015226 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015227 conserved repeat domain; Region: B_ant_repeat; TIGR01451 361100015228 Isochorismatase family; Region: Isochorismatase; pfam00857 361100015229 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 361100015230 catalytic triad [active] 361100015231 conserved cis-peptide bond; other site 361100015232 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 361100015233 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 361100015234 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 361100015235 potential frameshift: common BLAST hit: gi|47525771|ref|YP_017120.1| penicillin-binding protein, putative 361100015236 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 361100015237 Beta-lactamase; Region: Beta-lactamase; pfam00144 361100015238 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 361100015239 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 361100015240 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 361100015241 active site 361100015242 DNA binding site [nucleotide binding] 361100015243 Int/Topo IB signature motif; other site 361100015244 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100015245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100015246 TPR motif; other site 361100015247 binding surface 361100015248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100015249 salt bridge; other site 361100015250 non-specific DNA binding site [nucleotide binding]; other site 361100015251 sequence-specific DNA binding site [nucleotide binding]; other site 361100015252 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 361100015253 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 361100015254 ADP-ribose binding site [chemical binding]; other site 361100015255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100015256 dimerization interface [polypeptide binding]; other site 361100015257 putative DNA binding site [nucleotide binding]; other site 361100015258 putative Zn2+ binding site [ion binding]; other site 361100015259 Staphylococcal nuclease homologues; Region: SNc; smart00318 361100015260 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 361100015261 Catalytic site; other site 361100015262 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 361100015263 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 361100015264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 361100015265 Walker A/P-loop; other site 361100015266 ATP binding site [chemical binding]; other site 361100015267 Q-loop/lid; other site 361100015268 ABC transporter signature motif; other site 361100015269 Walker B; other site 361100015270 D-loop; other site 361100015271 H-loop/switch region; other site 361100015272 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 361100015273 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 361100015274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 361100015275 FeS/SAM binding site; other site 361100015276 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 361100015277 Predicted transcriptional regulators [Transcription]; Region: COG1725 361100015278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 361100015279 DNA-binding site [nucleotide binding]; DNA binding site 361100015280 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 361100015281 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 361100015282 Walker A/P-loop; other site 361100015283 ATP binding site [chemical binding]; other site 361100015284 Q-loop/lid; other site 361100015285 ABC transporter signature motif; other site 361100015286 Walker B; other site 361100015287 D-loop; other site 361100015288 H-loop/switch region; other site 361100015289 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 361100015290 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 361100015291 active site 361100015292 catalytic triad [active] 361100015293 transposase/IS protein; Provisional; Region: PRK09183 361100015294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 361100015295 Walker A motif; other site 361100015296 ATP binding site [chemical binding]; other site 361100015297 Walker B motif; other site 361100015298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 361100015299 Integrase core domain; Region: rve; pfam00665 361100015300 Nuclease-related domain; Region: NERD; pfam08378 361100015301 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 361100015302 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 361100015303 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 361100015304 putative active site [active] 361100015305 putative NTP binding site [chemical binding]; other site 361100015306 putative nucleic acid binding site [nucleotide binding]; other site 361100015307 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 361100015308 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 361100015309 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 361100015310 active site 361100015311 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 361100015312 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 361100015313 putative active site [active] 361100015314 putative NTP binding site [chemical binding]; other site 361100015315 putative nucleic acid binding site [nucleotide binding]; other site 361100015316 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 361100015317 active site 361100015318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 361100015319 ATP binding site [chemical binding]; other site 361100015320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 361100015321 S-adenosylmethionine binding site [chemical binding]; other site 361100015322 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 361100015323 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 361100015324 putative active site [active] 361100015325 putative NTP binding site [chemical binding]; other site 361100015326 putative nucleic acid binding site [nucleotide binding]; other site 361100015327 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 361100015328 active site 361100015329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 361100015330 Transposase; Region: HTH_Tnp_1; pfam01527 361100015331 putative transposase OrfB; Reviewed; Region: PHA02517 361100015332 HTH-like domain; Region: HTH_21; pfam13276 361100015333 Integrase core domain; Region: rve; pfam00665 361100015334 Integrase core domain; Region: rve_2; pfam13333 361100015335 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100015336 dimerization interface [polypeptide binding]; other site 361100015337 putative DNA binding site [nucleotide binding]; other site 361100015338 putative Zn2+ binding site [ion binding]; other site 361100015339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 361100015340 Chitin binding domain; Region: Chitin_bind_3; pfam03067 361100015341 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 361100015342 Interdomain contacts; other site 361100015343 Cytokine receptor motif; other site 361100015344 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 361100015345 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 361100015346 Interdomain contacts; other site 361100015347 Cytokine receptor motif; other site 361100015348 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 361100015349 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 361100015350 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 361100015351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 361100015352 PAS domain; Region: PAS_9; pfam13426 361100015353 putative active site [active] 361100015354 heme pocket [chemical binding]; other site 361100015355 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 361100015356 dimer interface [polypeptide binding]; other site 361100015357 putative CheW interface [polypeptide binding]; other site 361100015358 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 361100015359 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 361100015360 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 361100015361 active site 361100015362 Zn binding site [ion binding]; other site 361100015363 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 361100015364 putative active site [active] 361100015365 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 361100015366 NlpC/P60 family; Region: NLPC_P60; pfam00877 361100015367 putative transposase OrfB; Reviewed; Region: PHA02517 361100015368 HTH-like domain; Region: HTH_21; pfam13276 361100015369 Integrase core domain; Region: rve; pfam00665 361100015370 Integrase core domain; Region: rve_2; pfam13333 361100015371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 361100015372 Transposase; Region: HTH_Tnp_1; pfam01527 361100015373 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100015374 Tetratricopeptide repeat; Region: TPR_12; pfam13424 361100015375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 361100015376 TPR motif; other site 361100015377 binding surface 361100015378 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 361100015379 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 361100015380 Coenzyme A binding pocket [chemical binding]; other site 361100015381 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100015382 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 361100015383 catalytic residues [active] 361100015384 catalytic nucleophile [active] 361100015385 Presynaptic Site I dimer interface [polypeptide binding]; other site 361100015386 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 361100015387 Synaptic Flat tetramer interface [polypeptide binding]; other site 361100015388 Synaptic Site I dimer interface [polypeptide binding]; other site 361100015389 DNA binding site [nucleotide binding] 361100015390 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 361100015391 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 361100015392 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 361100015393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 361100015394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 361100015395 putative substrate translocation pore; other site 361100015396 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 361100015397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 361100015398 active site 361100015399 motif I; other site 361100015400 motif II; other site 361100015401 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 361100015402 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 361100015403 Homeodomain-like domain; Region: HTH_23; cl17451 361100015404 putative transposase OrfB; Reviewed; Region: PHA02517 361100015405 HTH-like domain; Region: HTH_21; pfam13276 361100015406 Integrase core domain; Region: rve; pfam00665 361100015407 Integrase core domain; Region: rve_2; pfam13333 361100015408 hypothetical protein; Provisional; Region: PRK09609 361100015409 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 361100015410 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 361100015411 Spore germination protein; Region: Spore_permease; cl17796 361100015412 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 361100015413 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 361100015414 Predicted membrane protein [Function unknown]; Region: COG2323 361100015415 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 361100015416 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 361100015417 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 361100015418 stage V sporulation protein AD; Provisional; Region: PRK12404 361100015419 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 361100015420 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 361100015421 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 361100015422 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 361100015423 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 361100015424 active site 361100015425 DNA binding site [nucleotide binding] 361100015426 Int/Topo IB signature motif; other site 361100015427 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 361100015428 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 361100015429 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 361100015430 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 361100015431 ATP-grasp domain; Region: ATP-grasp_4; cl17255 361100015432 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 361100015433 S-formylglutathione hydrolase; Region: PLN02442 361100015434 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 361100015435 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 361100015436 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 361100015437 substrate binding site [chemical binding]; other site 361100015438 catalytic Zn binding site [ion binding]; other site 361100015439 NAD binding site [chemical binding]; other site 361100015440 structural Zn binding site [ion binding]; other site 361100015441 dimer interface [polypeptide binding]; other site 361100015442 Predicted transcriptional regulators [Transcription]; Region: COG1733 361100015443 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 361100015444 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 361100015445 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 361100015446 catalytic residues [active] 361100015447 catalytic nucleophile [active] 361100015448 Presynaptic Site I dimer interface [polypeptide binding]; other site 361100015449 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 361100015450 Synaptic Flat tetramer interface [polypeptide binding]; other site 361100015451 Synaptic Site I dimer interface [polypeptide binding]; other site 361100015452 DNA binding site [nucleotide binding] 361100015453 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 361100015454 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 361100015455 IHF dimer interface [polypeptide binding]; other site 361100015456 IHF - DNA interface [nucleotide binding]; other site 361100015457 bacterial Hfq-like; Region: Hfq; cd01716 361100015458 hexamer interface [polypeptide binding]; other site 361100015459 Sm1 motif; other site 361100015460 RNA binding site [nucleotide binding]; other site 361100015461 Sm2 motif; other site 361100015462 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 361100015463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100015464 dimerization interface [polypeptide binding]; other site 361100015465 putative DNA binding site [nucleotide binding]; other site 361100015466 putative Zn2+ binding site [ion binding]; other site 361100015467 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 361100015468 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 361100015469 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 361100015470 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 361100015471 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 361100015472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 361100015473 putative DNA binding site [nucleotide binding]; other site 361100015474 putative Zn2+ binding site [ion binding]; other site 361100015475 AsnC family; Region: AsnC_trans_reg; pfam01037 361100015476 Uncharacterized conserved protein [Function unknown]; Region: COG2128 361100015477 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 361100015478 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 361100015479 EamA-like transporter family; Region: EamA; pfam00892 361100015480 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 361100015481 dimer interface [polypeptide binding]; other site 361100015482 putative tRNA-binding site [nucleotide binding]; other site 361100015483 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 361100015484 catalytic residues [active] 361100015485 Predicted membrane protein [Function unknown]; Region: COG2311 361100015486 Protein of unknown function (DUF418); Region: DUF418; cl12135 361100015487 Protein of unknown function (DUF418); Region: DUF418; pfam04235 361100015488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 361100015489 Helix-turn-helix domain; Region: HTH_28; pfam13518 361100015490 Helix-turn-helix domain; Region: HTH_28; pfam13518 361100015491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 361100015492 HTH-like domain; Region: HTH_21; pfam13276 361100015493 Integrase core domain; Region: rve; pfam00665 361100015494 Integrase core domain; Region: rve_2; pfam13333 361100015495 S-layer homology domain; Region: SLH; pfam00395 361100015496 S-layer homology domain; Region: SLH; pfam00395 361100015497 S-layer homology domain; Region: SLH; pfam00395 361100015498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 361100015499 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 361100015500 Probable transposase; Region: OrfB_IS605; pfam01385 361100015501 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 361100015502 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 361100015503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 361100015504 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 361100015505 Probable transposase; Region: OrfB_IS605; pfam01385 361100015506 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 361100015507 DNA binding residues [nucleotide binding] 361100015508 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 361100015509 Replication-relaxation; Region: Replic_Relax; pfam13814 361100015510 Domain of unknown function (DUF373); Region: DUF373; cl12079 361100015511 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 361100015512 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 361100015513 putative active site [active] 361100015514 putative NTP binding site [chemical binding]; other site 361100015515 putative nucleic acid binding site [nucleotide binding]; other site 361100015516 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 361100015517 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 361100015518 active site 361100015519 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 361100015520 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 361100015521 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 361100015522 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 361100015523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 361100015524 non-specific DNA binding site [nucleotide binding]; other site 361100015525 salt bridge; other site 361100015526 sequence-specific DNA binding site [nucleotide binding]; other site 361100015527 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 361100015528 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936