-- dump date 20140618_214508 -- class Genbank::misc_feature -- table misc_feature_note -- id note 405532000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 405532000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405532000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532000004 Walker A motif; other site 405532000005 ATP binding site [chemical binding]; other site 405532000006 Walker B motif; other site 405532000007 arginine finger; other site 405532000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 405532000009 DnaA box-binding interface [nucleotide binding]; other site 405532000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 405532000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405532000012 putative DNA binding surface [nucleotide binding]; other site 405532000013 dimer interface [polypeptide binding]; other site 405532000014 beta-clamp/clamp loader binding surface; other site 405532000015 beta-clamp/translesion DNA polymerase binding surface; other site 405532000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 405532000017 recombination protein F; Reviewed; Region: recF; PRK00064 405532000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 405532000019 Walker A/P-loop; other site 405532000020 ATP binding site [chemical binding]; other site 405532000021 Q-loop/lid; other site 405532000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532000023 ABC transporter signature motif; other site 405532000024 Walker B; other site 405532000025 D-loop; other site 405532000026 H-loop/switch region; other site 405532000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 405532000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532000029 Mg2+ binding site [ion binding]; other site 405532000030 G-X-G motif; other site 405532000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405532000032 anchoring element; other site 405532000033 dimer interface [polypeptide binding]; other site 405532000034 ATP binding site [chemical binding]; other site 405532000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405532000036 active site 405532000037 putative metal-binding site [ion binding]; other site 405532000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405532000039 DNA gyrase subunit A; Validated; Region: PRK05560 405532000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405532000041 CAP-like domain; other site 405532000042 active site 405532000043 primary dimer interface [polypeptide binding]; other site 405532000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532000050 YaaC-like Protein; Region: YaaC; pfam14175 405532000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 405532000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405532000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 405532000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405532000055 active site 405532000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405532000057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405532000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 405532000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 405532000061 active site 405532000062 multimer interface [polypeptide binding]; other site 405532000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 405532000064 predicted active site [active] 405532000065 catalytic triad [active] 405532000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 405532000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 405532000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 405532000069 dimer interface [polypeptide binding]; other site 405532000070 active site 405532000071 motif 1; other site 405532000072 motif 2; other site 405532000073 motif 3; other site 405532000074 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 405532000075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532000076 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405532000077 DNA binding residues [nucleotide binding] 405532000078 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405532000079 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405532000080 Substrate-binding site [chemical binding]; other site 405532000081 Substrate specificity [chemical binding]; other site 405532000082 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405532000083 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405532000084 Substrate-binding site [chemical binding]; other site 405532000085 Substrate specificity [chemical binding]; other site 405532000086 Isochorismatase family; Region: Isochorismatase; pfam00857 405532000087 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405532000088 catalytic triad [active] 405532000089 conserved cis-peptide bond; other site 405532000090 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 405532000091 nucleoside/Zn binding site; other site 405532000092 dimer interface [polypeptide binding]; other site 405532000093 catalytic motif [active] 405532000094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 405532000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532000096 Walker A motif; other site 405532000097 ATP binding site [chemical binding]; other site 405532000098 Walker B motif; other site 405532000099 arginine finger; other site 405532000100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 405532000101 hypothetical protein; Validated; Region: PRK00153 405532000102 recombination protein RecR; Reviewed; Region: recR; PRK00076 405532000103 RecR protein; Region: RecR; pfam02132 405532000104 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 405532000105 putative active site [active] 405532000106 putative metal-binding site [ion binding]; other site 405532000107 tetramer interface [polypeptide binding]; other site 405532000108 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 405532000109 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 405532000110 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 405532000111 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 405532000112 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405532000113 homodimer interface [polypeptide binding]; other site 405532000114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532000115 catalytic residue [active] 405532000116 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405532000117 thymidylate kinase; Validated; Region: tmk; PRK00698 405532000118 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 405532000119 TMP-binding site; other site 405532000120 ATP-binding site [chemical binding]; other site 405532000121 DNA polymerase III subunit delta'; Validated; Region: PRK08058 405532000122 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 405532000123 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 405532000124 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 405532000125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532000126 S-adenosylmethionine binding site [chemical binding]; other site 405532000127 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 405532000128 putative active site [active] 405532000129 GIY-YIG motif/motif A; other site 405532000130 putative metal binding site [ion binding]; other site 405532000131 Predicted methyltransferases [General function prediction only]; Region: COG0313 405532000132 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 405532000133 putative SAM binding site [chemical binding]; other site 405532000134 putative homodimer interface [polypeptide binding]; other site 405532000135 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405532000136 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405532000137 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 405532000138 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405532000139 active site 405532000140 HIGH motif; other site 405532000141 KMSKS motif; other site 405532000142 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405532000143 tRNA binding surface [nucleotide binding]; other site 405532000144 anticodon binding site; other site 405532000145 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 405532000146 dimer interface [polypeptide binding]; other site 405532000147 putative tRNA-binding site [nucleotide binding]; other site 405532000148 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 405532000149 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405532000150 active site 405532000151 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 405532000152 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 405532000153 putative active site [active] 405532000154 putative metal binding site [ion binding]; other site 405532000155 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 405532000156 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 405532000157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532000158 S-adenosylmethionine binding site [chemical binding]; other site 405532000159 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 405532000160 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 405532000161 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405532000162 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 405532000163 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405532000164 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405532000165 pur operon repressor; Provisional; Region: PRK09213 405532000166 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 405532000167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532000168 active site 405532000169 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405532000170 homotrimer interaction site [polypeptide binding]; other site 405532000171 putative active site [active] 405532000172 regulatory protein SpoVG; Reviewed; Region: PRK13259 405532000173 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 405532000174 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 405532000175 Substrate binding site; other site 405532000176 Mg++ binding site; other site 405532000177 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 405532000178 active site 405532000179 substrate binding site [chemical binding]; other site 405532000180 CoA binding site [chemical binding]; other site 405532000181 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 405532000182 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 405532000183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532000184 active site 405532000185 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 405532000186 putative active site [active] 405532000187 catalytic residue [active] 405532000188 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 405532000189 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 405532000190 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 405532000191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532000192 ATP binding site [chemical binding]; other site 405532000193 putative Mg++ binding site [ion binding]; other site 405532000194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532000195 nucleotide binding region [chemical binding]; other site 405532000196 ATP-binding site [chemical binding]; other site 405532000197 TRCF domain; Region: TRCF; pfam03461 405532000198 stage V sporulation protein T; Region: spore_V_T; TIGR02851 405532000199 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 405532000200 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405532000201 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405532000202 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 405532000203 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 405532000204 putative SAM binding site [chemical binding]; other site 405532000205 putative homodimer interface [polypeptide binding]; other site 405532000206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 405532000207 homodimer interface [polypeptide binding]; other site 405532000208 metal binding site [ion binding]; metal-binding site 405532000209 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 405532000210 homodimer interface [polypeptide binding]; other site 405532000211 active site 405532000212 putative chemical substrate binding site [chemical binding]; other site 405532000213 metal binding site [ion binding]; metal-binding site 405532000214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532000215 RNA binding surface [nucleotide binding]; other site 405532000216 sporulation protein YabP; Region: spore_yabP; TIGR02892 405532000217 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 405532000218 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 405532000219 Septum formation initiator; Region: DivIC; pfam04977 405532000220 hypothetical protein; Provisional; Region: PRK08582 405532000221 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 405532000222 RNA binding site [nucleotide binding]; other site 405532000223 stage II sporulation protein E; Region: spore_II_E; TIGR02865 405532000224 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 405532000225 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 405532000226 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 405532000227 Ligand Binding Site [chemical binding]; other site 405532000228 TilS substrate binding domain; Region: TilS; pfam09179 405532000229 TilS substrate C-terminal domain; Region: TilS_C; smart00977 405532000230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532000231 active site 405532000232 FtsH Extracellular; Region: FtsH_ext; pfam06480 405532000233 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 405532000234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532000235 Walker A motif; other site 405532000236 ATP binding site [chemical binding]; other site 405532000237 Walker B motif; other site 405532000238 arginine finger; other site 405532000239 Peptidase family M41; Region: Peptidase_M41; pfam01434 405532000240 pantothenate kinase; Reviewed; Region: PRK13318 405532000241 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 405532000242 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 405532000243 dimerization interface [polypeptide binding]; other site 405532000244 domain crossover interface; other site 405532000245 redox-dependent activation switch; other site 405532000246 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405532000247 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405532000248 dimer interface [polypeptide binding]; other site 405532000249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532000250 catalytic residue [active] 405532000251 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 405532000252 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405532000253 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405532000254 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 405532000255 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405532000256 glutamine binding [chemical binding]; other site 405532000257 catalytic triad [active] 405532000258 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405532000259 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 405532000260 homodimer interface [polypeptide binding]; other site 405532000261 substrate-cofactor binding pocket; other site 405532000262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532000263 catalytic residue [active] 405532000264 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 405532000265 dihydropteroate synthase; Region: DHPS; TIGR01496 405532000266 substrate binding pocket [chemical binding]; other site 405532000267 dimer interface [polypeptide binding]; other site 405532000268 inhibitor binding site; inhibition site 405532000269 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 405532000270 homooctamer interface [polypeptide binding]; other site 405532000271 active site 405532000272 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 405532000273 catalytic center binding site [active] 405532000274 ATP binding site [chemical binding]; other site 405532000275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532000276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532000277 non-specific DNA binding site [nucleotide binding]; other site 405532000278 salt bridge; other site 405532000279 sequence-specific DNA binding site [nucleotide binding]; other site 405532000280 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 405532000281 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405532000282 FMN binding site [chemical binding]; other site 405532000283 active site 405532000284 catalytic residues [active] 405532000285 substrate binding site [chemical binding]; other site 405532000286 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 405532000287 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 405532000288 dimer interface [polypeptide binding]; other site 405532000289 putative anticodon binding site; other site 405532000290 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 405532000291 motif 1; other site 405532000292 active site 405532000293 motif 2; other site 405532000294 motif 3; other site 405532000295 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 405532000296 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 405532000297 UvrB/uvrC motif; Region: UVR; pfam02151 405532000298 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 405532000299 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 405532000300 ADP binding site [chemical binding]; other site 405532000301 phosphagen binding site; other site 405532000302 substrate specificity loop; other site 405532000303 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 405532000304 Clp amino terminal domain; Region: Clp_N; pfam02861 405532000305 Clp amino terminal domain; Region: Clp_N; pfam02861 405532000306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532000307 Walker A motif; other site 405532000308 ATP binding site [chemical binding]; other site 405532000309 Walker B motif; other site 405532000310 arginine finger; other site 405532000311 UvrB/uvrC motif; Region: UVR; pfam02151 405532000312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532000313 Walker A motif; other site 405532000314 ATP binding site [chemical binding]; other site 405532000315 Walker B motif; other site 405532000316 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405532000317 DNA repair protein RadA; Provisional; Region: PRK11823 405532000318 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 405532000319 Walker A motif/ATP binding site; other site 405532000320 ATP binding site [chemical binding]; other site 405532000321 Walker B motif; other site 405532000322 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 405532000323 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 405532000324 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405532000325 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 405532000326 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 405532000327 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 405532000328 putative active site [active] 405532000329 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 405532000330 substrate binding site; other site 405532000331 dimer interface; other site 405532000332 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 405532000333 homotrimer interaction site [polypeptide binding]; other site 405532000334 zinc binding site [ion binding]; other site 405532000335 CDP-binding sites; other site 405532000336 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 405532000337 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405532000338 active site 405532000339 HIGH motif; other site 405532000340 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405532000341 active site 405532000342 KMSKS motif; other site 405532000343 serine O-acetyltransferase; Region: cysE; TIGR01172 405532000344 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 405532000345 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 405532000346 trimer interface [polypeptide binding]; other site 405532000347 active site 405532000348 substrate binding site [chemical binding]; other site 405532000349 CoA binding site [chemical binding]; other site 405532000350 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 405532000351 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405532000352 active site 405532000353 HIGH motif; other site 405532000354 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405532000355 KMSKS motif; other site 405532000356 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405532000357 tRNA binding surface [nucleotide binding]; other site 405532000358 anticodon binding site; other site 405532000359 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 405532000360 active site 405532000361 metal binding site [ion binding]; metal-binding site 405532000362 dimerization interface [polypeptide binding]; other site 405532000363 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 405532000364 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 405532000365 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405532000366 YacP-like NYN domain; Region: NYN_YacP; pfam05991 405532000367 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 405532000368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532000369 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405532000370 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 405532000371 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 405532000372 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 405532000373 putative homodimer interface [polypeptide binding]; other site 405532000374 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 405532000375 heterodimer interface [polypeptide binding]; other site 405532000376 homodimer interface [polypeptide binding]; other site 405532000377 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 405532000378 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 405532000379 23S rRNA interface [nucleotide binding]; other site 405532000380 L7/L12 interface [polypeptide binding]; other site 405532000381 putative thiostrepton binding site; other site 405532000382 L25 interface [polypeptide binding]; other site 405532000383 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 405532000384 mRNA/rRNA interface [nucleotide binding]; other site 405532000385 Ribosomal protein L10 leader 405532000386 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 405532000387 23S rRNA interface [nucleotide binding]; other site 405532000388 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 405532000389 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 405532000390 core dimer interface [polypeptide binding]; other site 405532000391 peripheral dimer interface [polypeptide binding]; other site 405532000392 L10 interface [polypeptide binding]; other site 405532000393 L11 interface [polypeptide binding]; other site 405532000394 putative EF-Tu interaction site [polypeptide binding]; other site 405532000395 putative EF-G interaction site [polypeptide binding]; other site 405532000396 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 405532000397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532000398 S-adenosylmethionine binding site [chemical binding]; other site 405532000399 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 405532000400 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405532000401 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 405532000402 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405532000403 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 405532000404 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405532000405 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 405532000406 RPB10 interaction site [polypeptide binding]; other site 405532000407 RPB1 interaction site [polypeptide binding]; other site 405532000408 RPB11 interaction site [polypeptide binding]; other site 405532000409 RPB3 interaction site [polypeptide binding]; other site 405532000410 RPB12 interaction site [polypeptide binding]; other site 405532000411 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 405532000412 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 405532000413 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 405532000414 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 405532000415 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 405532000416 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 405532000417 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 405532000418 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 405532000419 G-loop; other site 405532000420 DNA binding site [nucleotide binding] 405532000421 hypothetical protein; Provisional; Region: PRK06683 405532000422 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 405532000423 S17 interaction site [polypeptide binding]; other site 405532000424 S8 interaction site; other site 405532000425 16S rRNA interaction site [nucleotide binding]; other site 405532000426 streptomycin interaction site [chemical binding]; other site 405532000427 23S rRNA interaction site [nucleotide binding]; other site 405532000428 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 405532000429 30S ribosomal protein S7; Validated; Region: PRK05302 405532000430 elongation factor G; Reviewed; Region: PRK00007 405532000431 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 405532000432 G1 box; other site 405532000433 putative GEF interaction site [polypeptide binding]; other site 405532000434 GTP/Mg2+ binding site [chemical binding]; other site 405532000435 Switch I region; other site 405532000436 G2 box; other site 405532000437 G3 box; other site 405532000438 Switch II region; other site 405532000439 G4 box; other site 405532000440 G5 box; other site 405532000441 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 405532000442 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 405532000443 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 405532000444 elongation factor Tu; Reviewed; Region: PRK00049 405532000445 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 405532000446 G1 box; other site 405532000447 GEF interaction site [polypeptide binding]; other site 405532000448 GTP/Mg2+ binding site [chemical binding]; other site 405532000449 Switch I region; other site 405532000450 G2 box; other site 405532000451 G3 box; other site 405532000452 Switch II region; other site 405532000453 G4 box; other site 405532000454 G5 box; other site 405532000455 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 405532000456 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 405532000457 Antibiotic Binding Site [chemical binding]; other site 405532000458 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 405532000459 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 405532000460 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 405532000461 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 405532000462 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 405532000463 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 405532000464 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 405532000465 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 405532000466 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 405532000467 putative translocon binding site; other site 405532000468 protein-rRNA interface [nucleotide binding]; other site 405532000469 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 405532000470 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 405532000471 G-X-X-G motif; other site 405532000472 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 405532000473 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 405532000474 23S rRNA interface [nucleotide binding]; other site 405532000475 5S rRNA interface [nucleotide binding]; other site 405532000476 putative antibiotic binding site [chemical binding]; other site 405532000477 L25 interface [polypeptide binding]; other site 405532000478 L27 interface [polypeptide binding]; other site 405532000479 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 405532000480 23S rRNA interface [nucleotide binding]; other site 405532000481 putative translocon interaction site; other site 405532000482 signal recognition particle (SRP54) interaction site; other site 405532000483 L23 interface [polypeptide binding]; other site 405532000484 trigger factor interaction site; other site 405532000485 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 405532000486 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 405532000487 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 405532000488 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 405532000489 RNA binding site [nucleotide binding]; other site 405532000490 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 405532000491 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 405532000492 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 405532000493 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 405532000494 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 405532000495 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 405532000496 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405532000497 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405532000498 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 405532000499 5S rRNA interface [nucleotide binding]; other site 405532000500 L27 interface [polypeptide binding]; other site 405532000501 23S rRNA interface [nucleotide binding]; other site 405532000502 L5 interface [polypeptide binding]; other site 405532000503 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 405532000504 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 405532000505 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 405532000506 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 405532000507 23S rRNA binding site [nucleotide binding]; other site 405532000508 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 405532000509 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 405532000510 SecY translocase; Region: SecY; pfam00344 405532000511 adenylate kinase; Reviewed; Region: adk; PRK00279 405532000512 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 405532000513 AMP-binding site [chemical binding]; other site 405532000514 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 405532000515 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405532000516 active site 405532000517 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 405532000518 rRNA binding site [nucleotide binding]; other site 405532000519 predicted 30S ribosome binding site; other site 405532000520 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 405532000521 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 405532000522 30S ribosomal protein S13; Region: bact_S13; TIGR03631 405532000523 30S ribosomal protein S11; Validated; Region: PRK05309 405532000524 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 405532000525 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 405532000526 alphaNTD - beta interaction site [polypeptide binding]; other site 405532000527 alphaNTD homodimer interface [polypeptide binding]; other site 405532000528 alphaNTD - beta' interaction site [polypeptide binding]; other site 405532000529 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 405532000530 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 405532000531 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 405532000532 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405532000533 Walker A/P-loop; other site 405532000534 ATP binding site [chemical binding]; other site 405532000535 Q-loop/lid; other site 405532000536 ABC transporter signature motif; other site 405532000537 Walker B; other site 405532000538 D-loop; other site 405532000539 H-loop/switch region; other site 405532000540 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 405532000541 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405532000542 Walker A/P-loop; other site 405532000543 ATP binding site [chemical binding]; other site 405532000544 Q-loop/lid; other site 405532000545 ABC transporter signature motif; other site 405532000546 Walker B; other site 405532000547 D-loop; other site 405532000548 H-loop/switch region; other site 405532000549 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405532000550 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 405532000551 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405532000552 dimerization interface 3.5A [polypeptide binding]; other site 405532000553 active site 405532000554 Ribosomal protein L13 leader 405532000555 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 405532000556 23S rRNA interface [nucleotide binding]; other site 405532000557 L3 interface [polypeptide binding]; other site 405532000558 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 405532000559 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 405532000560 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405532000561 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405532000562 active site 405532000563 metal binding site [ion binding]; metal-binding site 405532000564 Domain of unknown function DUF59; Region: DUF59; cl00941 405532000565 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 405532000566 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 405532000567 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 405532000568 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405532000569 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 405532000570 NodB motif; other site 405532000571 putative active site [active] 405532000572 putative catalytic site [active] 405532000573 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 405532000574 Arginase family; Region: Arginase; cd09989 405532000575 agmatinase; Region: agmatinase; TIGR01230 405532000576 active site 405532000577 Mn binding site [ion binding]; other site 405532000578 oligomer interface [polypeptide binding]; other site 405532000579 Uncharacterized conserved protein [Function unknown]; Region: COG1624 405532000580 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405532000581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 405532000582 YbbR-like protein; Region: YbbR; pfam07949 405532000583 YbbR-like protein; Region: YbbR; pfam07949 405532000584 YbbR-like protein; Region: YbbR; pfam07949 405532000585 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 405532000586 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 405532000587 active site 405532000588 substrate binding site [chemical binding]; other site 405532000589 metal binding site [ion binding]; metal-binding site 405532000590 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 405532000591 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 405532000592 glutaminase active site [active] 405532000593 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 405532000594 dimer interface [polypeptide binding]; other site 405532000595 active site 405532000596 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 405532000597 dimer interface [polypeptide binding]; other site 405532000598 active site 405532000599 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 405532000600 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 405532000601 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405532000602 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 405532000603 Predicted membrane protein [Function unknown]; Region: COG2259 405532000604 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 405532000605 classical (c) SDRs; Region: SDR_c; cd05233 405532000606 NAD(P) binding site [chemical binding]; other site 405532000607 active site 405532000608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532000609 ABC-ATPase subunit interface; other site 405532000610 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 405532000611 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405532000612 Walker A/P-loop; other site 405532000613 ATP binding site [chemical binding]; other site 405532000614 Q-loop/lid; other site 405532000615 ABC transporter signature motif; other site 405532000616 Walker B; other site 405532000617 D-loop; other site 405532000618 H-loop/switch region; other site 405532000619 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405532000620 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 405532000621 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405532000622 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405532000623 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405532000624 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 405532000625 putative NAD(P) binding site [chemical binding]; other site 405532000626 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405532000627 FAD binding domain; Region: FAD_binding_4; pfam01565 405532000628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532000629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532000630 putative substrate translocation pore; other site 405532000631 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 405532000632 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405532000633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532000634 putative substrate translocation pore; other site 405532000635 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 405532000636 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 405532000637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405532000638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532000639 dimer interface [polypeptide binding]; other site 405532000640 conserved gate region; other site 405532000641 putative PBP binding loops; other site 405532000642 ABC-ATPase subunit interface; other site 405532000643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405532000644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532000645 dimer interface [polypeptide binding]; other site 405532000646 conserved gate region; other site 405532000647 putative PBP binding loops; other site 405532000648 ABC-ATPase subunit interface; other site 405532000649 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405532000650 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405532000651 Walker A/P-loop; other site 405532000652 ATP binding site [chemical binding]; other site 405532000653 Q-loop/lid; other site 405532000654 ABC transporter signature motif; other site 405532000655 Walker B; other site 405532000656 D-loop; other site 405532000657 H-loop/switch region; other site 405532000658 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405532000659 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405532000660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405532000661 Walker A/P-loop; other site 405532000662 ATP binding site [chemical binding]; other site 405532000663 Q-loop/lid; other site 405532000664 ABC transporter signature motif; other site 405532000665 Walker B; other site 405532000666 D-loop; other site 405532000667 H-loop/switch region; other site 405532000668 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 405532000669 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532000670 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532000671 peptide binding site [polypeptide binding]; other site 405532000672 YusW-like protein; Region: YusW; pfam14039 405532000673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532000674 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405532000675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532000676 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532000677 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532000678 peptide binding site [polypeptide binding]; other site 405532000679 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532000680 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532000681 peptide binding site [polypeptide binding]; other site 405532000682 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405532000683 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405532000684 active site 405532000685 catalytic tetrad [active] 405532000686 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 405532000687 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 405532000688 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 405532000689 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 405532000690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532000691 dimer interface [polypeptide binding]; other site 405532000692 conserved gate region; other site 405532000693 putative PBP binding loops; other site 405532000694 ABC-ATPase subunit interface; other site 405532000695 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 405532000696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405532000697 dimerization interface [polypeptide binding]; other site 405532000698 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405532000699 membrane-bound complex binding site; other site 405532000700 hinge residues; other site 405532000701 DNA binding domain, excisionase family; Region: excise; TIGR01764 405532000702 PBP superfamily domain; Region: PBP_like; pfam12727 405532000703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532000704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532000705 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405532000706 putative dimerization interface [polypeptide binding]; other site 405532000707 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532000708 EamA-like transporter family; Region: EamA; pfam00892 405532000709 YrzO-like protein; Region: YrzO; pfam14142 405532000710 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405532000711 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405532000712 putative acyl-acceptor binding pocket; other site 405532000713 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405532000714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405532000715 DNA binding site [nucleotide binding] 405532000716 domain linker motif; other site 405532000717 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405532000718 putative ligand binding site [chemical binding]; other site 405532000719 putative dimerization interface [polypeptide binding]; other site 405532000720 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532000721 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532000722 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532000723 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532000724 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405532000725 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405532000726 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 405532000727 active site 405532000728 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 405532000729 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 405532000730 NodB motif; other site 405532000731 putative active site [active] 405532000732 putative catalytic site [active] 405532000733 putative Zn binding site [ion binding]; other site 405532000734 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405532000735 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405532000736 catalytic residue [active] 405532000737 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 405532000738 nucleotide binding site/active site [active] 405532000739 HIT family signature motif; other site 405532000740 catalytic residue [active] 405532000741 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405532000742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532000743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532000744 ABC transporter; Region: ABC_tran_2; pfam12848 405532000745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532000746 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405532000747 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 405532000748 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405532000749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532000750 dimer interface [polypeptide binding]; other site 405532000751 conserved gate region; other site 405532000752 putative PBP binding loops; other site 405532000753 ABC-ATPase subunit interface; other site 405532000754 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405532000755 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405532000756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532000757 dimer interface [polypeptide binding]; other site 405532000758 conserved gate region; other site 405532000759 putative PBP binding loops; other site 405532000760 ABC-ATPase subunit interface; other site 405532000761 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405532000762 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405532000763 Walker A/P-loop; other site 405532000764 ATP binding site [chemical binding]; other site 405532000765 Q-loop/lid; other site 405532000766 ABC transporter signature motif; other site 405532000767 Walker B; other site 405532000768 D-loop; other site 405532000769 H-loop/switch region; other site 405532000770 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405532000771 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 405532000772 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405532000773 Walker A/P-loop; other site 405532000774 ATP binding site [chemical binding]; other site 405532000775 Q-loop/lid; other site 405532000776 ABC transporter signature motif; other site 405532000777 Walker B; other site 405532000778 D-loop; other site 405532000779 H-loop/switch region; other site 405532000780 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405532000781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532000782 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405532000783 active site 405532000784 motif I; other site 405532000785 motif II; other site 405532000786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532000787 motif II; other site 405532000788 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405532000789 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405532000790 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405532000791 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405532000792 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405532000793 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 405532000794 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 405532000795 dimer interface [polypeptide binding]; other site 405532000796 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 405532000797 active site 405532000798 Fe binding site [ion binding]; other site 405532000799 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405532000800 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 405532000801 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 405532000802 amino acid transporter; Region: 2A0306; TIGR00909 405532000803 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405532000804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532000805 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532000806 putative substrate translocation pore; other site 405532000807 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 405532000808 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405532000809 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 405532000810 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 405532000811 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405532000812 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405532000813 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405532000814 helicase 45; Provisional; Region: PTZ00424 405532000815 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405532000816 ATP binding site [chemical binding]; other site 405532000817 Mg++ binding site [ion binding]; other site 405532000818 motif III; other site 405532000819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532000820 nucleotide binding region [chemical binding]; other site 405532000821 ATP-binding site [chemical binding]; other site 405532000822 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 405532000823 Rhomboid family; Region: Rhomboid; pfam01694 405532000824 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 405532000825 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 405532000826 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 405532000827 alanine racemase; Reviewed; Region: alr; PRK00053 405532000828 active site 405532000829 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405532000830 dimer interface [polypeptide binding]; other site 405532000831 substrate binding site [chemical binding]; other site 405532000832 catalytic residues [active] 405532000833 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 405532000834 PemK-like protein; Region: PemK; pfam02452 405532000835 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 405532000836 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 405532000837 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 405532000838 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 405532000839 RNA binding site [nucleotide binding]; other site 405532000840 hypothetical protein; Provisional; Region: PRK04351 405532000841 SprT homologues; Region: SprT; cl01182 405532000842 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 405532000843 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405532000844 Glycoprotease family; Region: Peptidase_M22; pfam00814 405532000845 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405532000846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532000847 Coenzyme A binding pocket [chemical binding]; other site 405532000848 UGMP family protein; Validated; Region: PRK09604 405532000849 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405532000850 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405532000851 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405532000852 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532000853 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532000854 ABC transporter; Region: ABC_tran_2; pfam12848 405532000855 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532000856 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 405532000857 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 405532000858 CoA binding domain; Region: CoA_binding; pfam02629 405532000859 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 405532000860 CAAX protease self-immunity; Region: Abi; pfam02517 405532000861 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 405532000862 oligomerisation interface [polypeptide binding]; other site 405532000863 mobile loop; other site 405532000864 roof hairpin; other site 405532000865 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 405532000866 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 405532000867 ring oligomerisation interface [polypeptide binding]; other site 405532000868 ATP/Mg binding site [chemical binding]; other site 405532000869 stacking interactions; other site 405532000870 hinge regions; other site 405532000871 GMP synthase; Reviewed; Region: guaA; PRK00074 405532000872 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 405532000873 AMP/PPi binding site [chemical binding]; other site 405532000874 candidate oxyanion hole; other site 405532000875 catalytic triad [active] 405532000876 potential glutamine specificity residues [chemical binding]; other site 405532000877 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 405532000878 ATP Binding subdomain [chemical binding]; other site 405532000879 Ligand Binding sites [chemical binding]; other site 405532000880 Dimerization subdomain; other site 405532000881 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405532000882 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532000883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532000884 active site 405532000885 phosphorylation site [posttranslational modification] 405532000886 intermolecular recognition site; other site 405532000887 dimerization interface [polypeptide binding]; other site 405532000888 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532000889 DNA binding site [nucleotide binding] 405532000890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532000891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532000892 dimerization interface [polypeptide binding]; other site 405532000893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532000894 dimer interface [polypeptide binding]; other site 405532000895 phosphorylation site [posttranslational modification] 405532000896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532000897 ATP binding site [chemical binding]; other site 405532000898 Mg2+ binding site [ion binding]; other site 405532000899 G-X-G motif; other site 405532000900 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405532000901 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532000902 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405532000903 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405532000904 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 405532000905 catalytic residues [active] 405532000906 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 405532000907 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405532000908 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405532000909 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532000910 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405532000911 Walker A/P-loop; other site 405532000912 ATP binding site [chemical binding]; other site 405532000913 Q-loop/lid; other site 405532000914 ABC transporter signature motif; other site 405532000915 Walker B; other site 405532000916 D-loop; other site 405532000917 H-loop/switch region; other site 405532000918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532000919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532000920 ATP binding site [chemical binding]; other site 405532000921 Mg2+ binding site [ion binding]; other site 405532000922 G-X-G motif; other site 405532000923 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532000924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532000925 active site 405532000926 phosphorylation site [posttranslational modification] 405532000927 intermolecular recognition site; other site 405532000928 dimerization interface [polypeptide binding]; other site 405532000929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532000930 DNA binding site [nucleotide binding] 405532000931 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 405532000932 putative ligand binding site [chemical binding]; other site 405532000933 putative catalytic site [active] 405532000934 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405532000935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532000936 S-adenosylmethionine binding site [chemical binding]; other site 405532000937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532000938 S-adenosylmethionine binding site [chemical binding]; other site 405532000939 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 405532000940 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405532000941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532000942 NAD(P) binding site [chemical binding]; other site 405532000943 active site 405532000944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532000945 S-adenosylmethionine binding site [chemical binding]; other site 405532000946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405532000947 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405532000948 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405532000949 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532000950 active site 405532000951 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532000952 EamA-like transporter family; Region: EamA; pfam00892 405532000953 EamA-like transporter family; Region: EamA; pfam00892 405532000954 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 405532000955 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 405532000956 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 405532000957 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 405532000958 NAD binding site [chemical binding]; other site 405532000959 ATP-grasp domain; Region: ATP-grasp; pfam02222 405532000960 adenylosuccinate lyase; Provisional; Region: PRK07492 405532000961 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 405532000962 tetramer interface [polypeptide binding]; other site 405532000963 active site 405532000964 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 405532000965 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 405532000966 ATP binding site [chemical binding]; other site 405532000967 active site 405532000968 substrate binding site [chemical binding]; other site 405532000969 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 405532000970 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 405532000971 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 405532000972 putative active site [active] 405532000973 catalytic triad [active] 405532000974 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 405532000975 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 405532000976 dimerization interface [polypeptide binding]; other site 405532000977 ATP binding site [chemical binding]; other site 405532000978 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 405532000979 dimerization interface [polypeptide binding]; other site 405532000980 ATP binding site [chemical binding]; other site 405532000981 amidophosphoribosyltransferase; Provisional; Region: PRK06781 405532000982 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 405532000983 active site 405532000984 tetramer interface [polypeptide binding]; other site 405532000985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532000986 active site 405532000987 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 405532000988 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 405532000989 dimerization interface [polypeptide binding]; other site 405532000990 putative ATP binding site [chemical binding]; other site 405532000991 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 405532000992 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 405532000993 active site 405532000994 substrate binding site [chemical binding]; other site 405532000995 cosubstrate binding site; other site 405532000996 catalytic site [active] 405532000997 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 405532000998 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 405532000999 purine monophosphate binding site [chemical binding]; other site 405532001000 dimer interface [polypeptide binding]; other site 405532001001 putative catalytic residues [active] 405532001002 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 405532001003 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 405532001004 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 405532001005 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 405532001006 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 405532001007 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 405532001008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 405532001009 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 405532001010 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405532001011 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 405532001012 PcrB family; Region: PcrB; pfam01884 405532001013 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 405532001014 substrate binding site [chemical binding]; other site 405532001015 putative active site [active] 405532001016 dimer interface [polypeptide binding]; other site 405532001017 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 405532001018 Part of AAA domain; Region: AAA_19; pfam13245 405532001019 Family description; Region: UvrD_C_2; pfam13538 405532001020 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 405532001021 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 405532001022 nucleotide binding pocket [chemical binding]; other site 405532001023 K-X-D-G motif; other site 405532001024 catalytic site [active] 405532001025 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 405532001026 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 405532001027 Dimer interface [polypeptide binding]; other site 405532001028 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 405532001029 putative dimer interface [polypeptide binding]; other site 405532001030 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 405532001031 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 405532001032 putative dimer interface [polypeptide binding]; other site 405532001033 hypothetical protein; Provisional; Region: PRK10621 405532001034 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405532001035 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 405532001036 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 405532001037 Glutamate binding site [chemical binding]; other site 405532001038 homodimer interface [polypeptide binding]; other site 405532001039 NAD binding site [chemical binding]; other site 405532001040 catalytic residues [active] 405532001041 Isochorismatase family; Region: Isochorismatase; pfam00857 405532001042 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405532001043 catalytic triad [active] 405532001044 conserved cis-peptide bond; other site 405532001045 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 405532001046 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405532001047 Walker A/P-loop; other site 405532001048 ATP binding site [chemical binding]; other site 405532001049 Q-loop/lid; other site 405532001050 ABC transporter signature motif; other site 405532001051 Walker B; other site 405532001052 D-loop; other site 405532001053 H-loop/switch region; other site 405532001054 NIL domain; Region: NIL; pfam09383 405532001055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532001056 dimer interface [polypeptide binding]; other site 405532001057 conserved gate region; other site 405532001058 ABC-ATPase subunit interface; other site 405532001059 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405532001060 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405532001061 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 405532001062 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 405532001063 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 405532001064 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 405532001065 P loop; other site 405532001066 Nucleotide binding site [chemical binding]; other site 405532001067 DTAP/Switch II; other site 405532001068 Switch I; other site 405532001069 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405532001070 putative dimer interface [polypeptide binding]; other site 405532001071 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532001072 MarR family; Region: MarR; pfam01047 405532001073 MarR family; Region: MarR_2; cl17246 405532001074 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 405532001075 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 405532001076 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 405532001077 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 405532001078 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 405532001079 GatB domain; Region: GatB_Yqey; pfam02637 405532001080 putative lipid kinase; Reviewed; Region: PRK13337 405532001081 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405532001082 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405532001083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532001084 motif II; other site 405532001085 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 405532001086 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405532001087 inhibitor-cofactor binding pocket; inhibition site 405532001088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532001089 catalytic residue [active] 405532001090 PAS domain; Region: PAS_9; pfam13426 405532001091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532001092 putative active site [active] 405532001093 heme pocket [chemical binding]; other site 405532001094 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 405532001095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532001096 Walker A motif; other site 405532001097 ATP binding site [chemical binding]; other site 405532001098 Walker B motif; other site 405532001099 arginine finger; other site 405532001100 succinic semialdehyde dehydrogenase; Region: PLN02278 405532001101 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 405532001102 tetramerization interface [polypeptide binding]; other site 405532001103 NAD(P) binding site [chemical binding]; other site 405532001104 catalytic residues [active] 405532001105 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405532001106 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 405532001107 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405532001108 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405532001109 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405532001110 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 405532001111 putative active site [active] 405532001112 putative metal binding site [ion binding]; other site 405532001113 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405532001114 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405532001115 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405532001116 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 405532001117 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 405532001118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532001119 S-adenosylmethionine binding site [chemical binding]; other site 405532001120 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 405532001121 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405532001122 FMN binding site [chemical binding]; other site 405532001123 active site 405532001124 catalytic residues [active] 405532001125 substrate binding site [chemical binding]; other site 405532001126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 405532001127 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405532001128 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405532001129 Protein of unknown function DUF45; Region: DUF45; pfam01863 405532001130 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 405532001131 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 405532001132 active site 405532001133 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405532001134 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 405532001135 amidohydrolase; Region: amidohydrolases; TIGR01891 405532001136 metal binding site [ion binding]; metal-binding site 405532001137 putative dimer interface [polypeptide binding]; other site 405532001138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532001139 S-adenosylmethionine binding site [chemical binding]; other site 405532001140 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 405532001141 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 405532001142 catalytic residue [active] 405532001143 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 405532001144 catalytic residues [active] 405532001145 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532001146 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532001147 peroxiredoxin; Region: AhpC; TIGR03137 405532001148 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 405532001149 dimer interface [polypeptide binding]; other site 405532001150 decamer (pentamer of dimers) interface [polypeptide binding]; other site 405532001151 catalytic triad [active] 405532001152 peroxidatic and resolving cysteines [active] 405532001153 5-methylribose kinase; Reviewed; Region: PRK12396 405532001154 Phosphotransferase enzyme family; Region: APH; pfam01636 405532001155 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 405532001156 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 405532001157 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 405532001158 intersubunit interface [polypeptide binding]; other site 405532001159 active site 405532001160 Zn2+ binding site [ion binding]; other site 405532001161 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405532001162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532001163 ABC-ATPase subunit interface; other site 405532001164 dimer interface [polypeptide binding]; other site 405532001165 putative PBP binding regions; other site 405532001166 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405532001167 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532001168 ABC-ATPase subunit interface; other site 405532001169 dimer interface [polypeptide binding]; other site 405532001170 putative PBP binding regions; other site 405532001171 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405532001172 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405532001173 putative ligand binding residues [chemical binding]; other site 405532001174 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 405532001175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532001176 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 405532001177 DNA binding domain, excisionase family; Region: excise; TIGR01764 405532001178 Sm and related proteins; Region: Sm_like; cl00259 405532001179 Sm1 motif; other site 405532001180 RNA binding site [nucleotide binding]; other site 405532001181 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 405532001182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532001183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532001184 dimer interface [polypeptide binding]; other site 405532001185 phosphorylation site [posttranslational modification] 405532001186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532001187 ATP binding site [chemical binding]; other site 405532001188 Mg2+ binding site [ion binding]; other site 405532001189 G-X-G motif; other site 405532001190 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 405532001191 hypothetical protein; Provisional; Region: PRK06851 405532001192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532001193 Walker A motif; other site 405532001194 ATP binding site [chemical binding]; other site 405532001195 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 405532001196 benzoate transport; Region: 2A0115; TIGR00895 405532001197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532001198 putative substrate translocation pore; other site 405532001199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532001200 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405532001201 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405532001202 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 405532001203 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 405532001204 [2Fe-2S] cluster binding site [ion binding]; other site 405532001205 Fatty acid desaturase; Region: FA_desaturase; pfam00487 405532001206 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 405532001207 putative di-iron ligands [ion binding]; other site 405532001208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532001209 dimer interface [polypeptide binding]; other site 405532001210 conserved gate region; other site 405532001211 putative PBP binding loops; other site 405532001212 ABC-ATPase subunit interface; other site 405532001213 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405532001214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405532001215 substrate binding pocket [chemical binding]; other site 405532001216 membrane-bound complex binding site; other site 405532001217 hinge residues; other site 405532001218 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405532001219 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405532001220 Walker A/P-loop; other site 405532001221 ATP binding site [chemical binding]; other site 405532001222 Q-loop/lid; other site 405532001223 ABC transporter signature motif; other site 405532001224 Walker B; other site 405532001225 D-loop; other site 405532001226 H-loop/switch region; other site 405532001227 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405532001228 HAMP domain; Region: HAMP; pfam00672 405532001229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532001230 dimer interface [polypeptide binding]; other site 405532001231 putative CheW interface [polypeptide binding]; other site 405532001232 Arginine repressor [Transcription]; Region: ArgR; COG1438 405532001233 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 405532001234 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 405532001235 arginine deiminase; Provisional; Region: PRK01388 405532001236 ornithine carbamoyltransferase; Validated; Region: PRK02102 405532001237 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405532001238 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405532001239 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405532001240 carbamate kinase; Reviewed; Region: PRK12686 405532001241 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 405532001242 putative substrate binding site [chemical binding]; other site 405532001243 nucleotide binding site [chemical binding]; other site 405532001244 nucleotide binding site [chemical binding]; other site 405532001245 homodimer interface [polypeptide binding]; other site 405532001246 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405532001247 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405532001248 ligand binding site [chemical binding]; other site 405532001249 flexible hinge region; other site 405532001250 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 405532001251 putative switch regulator; other site 405532001252 non-specific DNA interactions [nucleotide binding]; other site 405532001253 DNA binding site [nucleotide binding] 405532001254 sequence specific DNA binding site [nucleotide binding]; other site 405532001255 putative cAMP binding site [chemical binding]; other site 405532001256 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405532001257 FAD binding domain; Region: FAD_binding_4; pfam01565 405532001258 Berberine and berberine like; Region: BBE; pfam08031 405532001259 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405532001260 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405532001261 Ca binding site [ion binding]; other site 405532001262 active site 405532001263 catalytic site [active] 405532001264 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405532001265 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 405532001266 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405532001267 active site turn [active] 405532001268 phosphorylation site [posttranslational modification] 405532001269 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 405532001270 putative catalytic site [active] 405532001271 putative metal binding site [ion binding]; other site 405532001272 putative phosphate binding site [ion binding]; other site 405532001273 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405532001274 Predicted membrane protein [Function unknown]; Region: COG1511 405532001275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532001276 DNA topoisomerase III; Provisional; Region: PRK07726 405532001277 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405532001278 active site 405532001279 putative interdomain interaction site [polypeptide binding]; other site 405532001280 putative metal-binding site [ion binding]; other site 405532001281 putative nucleotide binding site [chemical binding]; other site 405532001282 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405532001283 domain I; other site 405532001284 DNA binding groove [nucleotide binding] 405532001285 phosphate binding site [ion binding]; other site 405532001286 domain II; other site 405532001287 domain III; other site 405532001288 nucleotide binding site [chemical binding]; other site 405532001289 catalytic site [active] 405532001290 domain IV; other site 405532001291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405532001292 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 405532001293 Protein of unknown function (DUF524); Region: DUF524; pfam04411 405532001294 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 405532001295 catalytic nucleophile [active] 405532001296 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405532001297 active site 405532001298 putative metal-binding site [ion binding]; other site 405532001299 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 405532001300 substrate binding site [chemical binding]; other site 405532001301 multimerization interface [polypeptide binding]; other site 405532001302 ATP binding site [chemical binding]; other site 405532001303 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 405532001304 thiamine phosphate binding site [chemical binding]; other site 405532001305 active site 405532001306 pyrophosphate binding site [ion binding]; other site 405532001307 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 405532001308 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 405532001309 HAMP domain; Region: HAMP; pfam00672 405532001310 dimerization interface [polypeptide binding]; other site 405532001311 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532001312 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532001313 dimer interface [polypeptide binding]; other site 405532001314 putative CheW interface [polypeptide binding]; other site 405532001315 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405532001316 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405532001317 acyl-activating enzyme (AAE) consensus motif; other site 405532001318 AMP binding site [chemical binding]; other site 405532001319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532001320 thioester reductase domain; Region: Thioester-redct; TIGR01746 405532001321 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 405532001322 putative NAD(P) binding site [chemical binding]; other site 405532001323 active site 405532001324 putative substrate binding site [chemical binding]; other site 405532001325 Domain of unknown function DUF77; Region: DUF77; pfam01910 405532001326 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405532001327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532001328 dimer interface [polypeptide binding]; other site 405532001329 conserved gate region; other site 405532001330 putative PBP binding loops; other site 405532001331 ABC-ATPase subunit interface; other site 405532001332 NMT1/THI5 like; Region: NMT1; pfam09084 405532001333 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 405532001334 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405532001335 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405532001336 Walker A/P-loop; other site 405532001337 ATP binding site [chemical binding]; other site 405532001338 Q-loop/lid; other site 405532001339 ABC transporter signature motif; other site 405532001340 Walker B; other site 405532001341 D-loop; other site 405532001342 H-loop/switch region; other site 405532001343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532001344 H-loop/switch region; other site 405532001345 Glyco_18 domain; Region: Glyco_18; smart00636 405532001346 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 405532001347 active site 405532001348 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405532001349 Interdomain contacts; other site 405532001350 Cytokine receptor motif; other site 405532001351 Cellulose binding domain; Region: CBM_2; pfam00553 405532001352 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 405532001353 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405532001354 catalytic residues [active] 405532001355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532001356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532001357 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 405532001358 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532001359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532001360 putative substrate translocation pore; other site 405532001361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532001362 non-specific DNA binding site [nucleotide binding]; other site 405532001363 salt bridge; other site 405532001364 sequence-specific DNA binding site [nucleotide binding]; other site 405532001365 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 405532001366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532001367 putative substrate translocation pore; other site 405532001368 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 405532001369 Uncharacterized conserved protein [Function unknown]; Region: COG3379 405532001370 YesK-like protein; Region: YesK; pfam14150 405532001371 prolyl-tRNA synthetase; Provisional; Region: PRK08661 405532001372 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 405532001373 dimer interface [polypeptide binding]; other site 405532001374 motif 1; other site 405532001375 active site 405532001376 motif 2; other site 405532001377 motif 3; other site 405532001378 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 405532001379 anticodon binding site; other site 405532001380 zinc-binding site [ion binding]; other site 405532001381 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405532001382 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405532001383 nucleotide binding site [chemical binding]; other site 405532001384 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405532001385 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405532001386 putative metal binding site [ion binding]; other site 405532001387 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405532001388 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405532001389 putative metal binding site [ion binding]; other site 405532001390 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405532001391 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405532001392 putative metal binding site [ion binding]; other site 405532001393 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 405532001394 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 405532001395 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 405532001396 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405532001397 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405532001398 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405532001399 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405532001400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532001401 motif II; other site 405532001402 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405532001403 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 405532001404 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405532001405 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405532001406 active site 405532001407 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 405532001408 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 405532001409 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 405532001410 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405532001411 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405532001412 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532001413 EamA-like transporter family; Region: EamA; pfam00892 405532001414 EamA-like transporter family; Region: EamA; pfam00892 405532001415 YhhN-like protein; Region: YhhN; pfam07947 405532001416 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405532001417 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405532001418 Catalytic site [active] 405532001419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532001420 binding surface 405532001421 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405532001422 TPR motif; other site 405532001423 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405532001424 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405532001425 Predicted membrane protein [Function unknown]; Region: COG2510 405532001426 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 405532001427 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 405532001428 calcium/proton exchanger (cax); Region: cax; TIGR00378 405532001429 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 405532001430 YfkD-like protein; Region: YfkD; pfam14167 405532001431 Radical SAM superfamily; Region: Radical_SAM; pfam04055 405532001432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532001433 FeS/SAM binding site; other site 405532001434 YfkB-like domain; Region: YfkB; pfam08756 405532001435 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 405532001436 Fumarase C-terminus; Region: Fumerase_C; pfam05683 405532001437 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 405532001438 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405532001439 NodB motif; other site 405532001440 active site 405532001441 catalytic site [active] 405532001442 Cd binding site [ion binding]; other site 405532001443 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405532001444 endonuclease III; Region: ENDO3c; smart00478 405532001445 minor groove reading motif; other site 405532001446 helix-hairpin-helix signature motif; other site 405532001447 substrate binding pocket [chemical binding]; other site 405532001448 active site 405532001449 TRAM domain; Region: TRAM; pfam01938 405532001450 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 405532001451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532001452 S-adenosylmethionine binding site [chemical binding]; other site 405532001453 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 405532001454 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405532001455 dimerization interface 3.5A [polypeptide binding]; other site 405532001456 active site 405532001457 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 405532001458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532001459 Walker A motif; other site 405532001460 ATP binding site [chemical binding]; other site 405532001461 Walker B motif; other site 405532001462 arginine finger; other site 405532001463 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405532001464 hypothetical protein; Validated; Region: PRK06748 405532001465 S-methylmethionine transporter; Provisional; Region: PRK11387 405532001466 acetylornithine deacetylase; Validated; Region: PRK08596 405532001467 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405532001468 metal binding site [ion binding]; metal-binding site 405532001469 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532001470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532001471 non-specific DNA binding site [nucleotide binding]; other site 405532001472 salt bridge; other site 405532001473 sequence-specific DNA binding site [nucleotide binding]; other site 405532001474 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 405532001475 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 405532001476 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 405532001477 glutaminase A; Region: Gln_ase; TIGR03814 405532001478 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405532001479 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 405532001480 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405532001481 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405532001482 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405532001483 active site turn [active] 405532001484 phosphorylation site [posttranslational modification] 405532001485 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532001486 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532001487 Sm and related proteins; Region: Sm_like; cl00259 405532001488 heptamer interface [polypeptide binding]; other site 405532001489 Sm1 motif; other site 405532001490 hexamer interface [polypeptide binding]; other site 405532001491 RNA binding site [nucleotide binding]; other site 405532001492 Sm2 motif; other site 405532001493 Sm and related proteins; Region: Sm_like; cl00259 405532001494 heptamer interface [polypeptide binding]; other site 405532001495 Sm1 motif; other site 405532001496 hexamer interface [polypeptide binding]; other site 405532001497 RNA binding site [nucleotide binding]; other site 405532001498 Sm2 motif; other site 405532001499 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405532001500 active site 405532001501 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405532001502 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405532001503 active site 405532001504 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 405532001505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532001506 NAD(P) binding site [chemical binding]; other site 405532001507 active site 405532001508 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405532001509 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 405532001510 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405532001511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532001512 NAD(P) binding site [chemical binding]; other site 405532001513 active site 405532001514 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532001515 active site 405532001516 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405532001517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532001518 active site 405532001519 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 405532001520 Pyruvate formate lyase 1; Region: PFL1; cd01678 405532001521 coenzyme A binding site [chemical binding]; other site 405532001522 active site 405532001523 catalytic residues [active] 405532001524 glycine loop; other site 405532001525 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 405532001526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532001527 FeS/SAM binding site; other site 405532001528 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 405532001529 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 405532001530 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405532001531 YfhE-like protein; Region: YfhE; pfam14152 405532001532 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532001533 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 405532001534 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 405532001535 active site 405532001536 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 405532001537 TIGR01777 family protein; Region: yfcH 405532001538 putative NAD(P) binding site [chemical binding]; other site 405532001539 putative active site [active] 405532001540 recombination regulator RecX; Provisional; Region: recX; PRK14135 405532001541 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 405532001542 YpzG-like protein; Region: YpzG; pfam14139 405532001543 Small acid-soluble spore protein K family; Region: SspK; pfam08176 405532001544 WVELL protein; Region: WVELL; pfam14043 405532001545 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 405532001546 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 405532001547 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405532001548 minor groove reading motif; other site 405532001549 helix-hairpin-helix signature motif; other site 405532001550 substrate binding pocket [chemical binding]; other site 405532001551 active site 405532001552 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 405532001553 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 405532001554 DNA binding and oxoG recognition site [nucleotide binding] 405532001555 YgaB-like protein; Region: YgaB; pfam14182 405532001556 hypothetical protein; Provisional; Region: PRK13662 405532001557 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405532001558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532001559 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405532001560 Walker A/P-loop; other site 405532001561 ATP binding site [chemical binding]; other site 405532001562 Q-loop/lid; other site 405532001563 ABC transporter signature motif; other site 405532001564 Walker B; other site 405532001565 D-loop; other site 405532001566 H-loop/switch region; other site 405532001567 Predicted membrane protein [Function unknown]; Region: COG4129 405532001568 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405532001569 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 405532001570 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 405532001571 active site 405532001572 dimer interface [polypeptide binding]; other site 405532001573 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 405532001574 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 405532001575 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 405532001576 active site 405532001577 FMN binding site [chemical binding]; other site 405532001578 substrate binding site [chemical binding]; other site 405532001579 3Fe-4S cluster binding site [ion binding]; other site 405532001580 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 405532001581 domain_subunit interface; other site 405532001582 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 405532001583 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405532001584 inhibitor-cofactor binding pocket; inhibition site 405532001585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532001586 catalytic residue [active] 405532001587 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 405532001588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532001589 Walker A/P-loop; other site 405532001590 ATP binding site [chemical binding]; other site 405532001591 Q-loop/lid; other site 405532001592 ABC transporter signature motif; other site 405532001593 Walker B; other site 405532001594 D-loop; other site 405532001595 H-loop/switch region; other site 405532001596 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405532001597 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405532001598 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405532001599 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405532001600 Ion channel; Region: Ion_trans_2; pfam07885 405532001601 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 405532001602 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 405532001603 catalytic triad [active] 405532001604 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405532001605 metal binding site 2 [ion binding]; metal-binding site 405532001606 putative DNA binding helix; other site 405532001607 metal binding site 1 [ion binding]; metal-binding site 405532001608 dimer interface [polypeptide binding]; other site 405532001609 structural Zn2+ binding site [ion binding]; other site 405532001610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532001611 Coenzyme A binding pocket [chemical binding]; other site 405532001612 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 405532001613 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 405532001614 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405532001615 active site 405532001616 DNA binding site [nucleotide binding] 405532001617 Int/Topo IB signature motif; other site 405532001618 Restriction endonuclease; Region: Mrr_cat; pfam04471 405532001619 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405532001620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532001621 ATP binding site [chemical binding]; other site 405532001622 putative Mg++ binding site [ion binding]; other site 405532001623 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 405532001624 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405532001625 Phage capsid family; Region: Phage_capsid; pfam05065 405532001626 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 405532001627 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 405532001628 putative active site [active] 405532001629 putative NTP binding site [chemical binding]; other site 405532001630 putative nucleic acid binding site [nucleotide binding]; other site 405532001631 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 405532001632 hypothetical protein; Provisional; Region: PRK12378 405532001633 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405532001634 nudix motif; other site 405532001635 Transglycosylase; Region: Transgly; pfam00912 405532001636 Thioredoxin; Region: Thioredoxin_4; pfam13462 405532001637 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 405532001638 epoxyqueuosine reductase; Region: TIGR00276 405532001639 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 405532001640 4Fe-4S binding domain; Region: Fer4; cl02805 405532001641 Putative amidase domain; Region: Amidase_6; pfam12671 405532001642 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 405532001643 PAS fold; Region: PAS_4; pfam08448 405532001644 PAS domain; Region: PAS_9; pfam13426 405532001645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532001646 putative active site [active] 405532001647 heme pocket [chemical binding]; other site 405532001648 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405532001649 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405532001650 metal binding site [ion binding]; metal-binding site 405532001651 active site 405532001652 I-site; other site 405532001653 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405532001654 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 405532001655 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 405532001656 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 405532001657 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405532001658 heme-binding site [chemical binding]; other site 405532001659 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532001660 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532001661 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532001662 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532001663 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532001664 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532001665 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405532001666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532001667 Coenzyme A binding pocket [chemical binding]; other site 405532001668 BCCT family transporter; Region: BCCT; pfam02028 405532001669 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 405532001670 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405532001671 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 405532001672 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405532001673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 405532001674 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 405532001675 Tar ligand binding domain homologue; Region: TarH; pfam02203 405532001676 Cache domain; Region: Cache_1; pfam02743 405532001677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532001678 dimerization interface [polypeptide binding]; other site 405532001679 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532001680 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532001681 dimer interface [polypeptide binding]; other site 405532001682 putative CheW interface [polypeptide binding]; other site 405532001683 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 405532001684 PAS domain; Region: PAS; smart00091 405532001685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532001686 ATP binding site [chemical binding]; other site 405532001687 Mg2+ binding site [ion binding]; other site 405532001688 G-X-G motif; other site 405532001689 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405532001690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532001691 active site 405532001692 phosphorylation site [posttranslational modification] 405532001693 intermolecular recognition site; other site 405532001694 dimerization interface [polypeptide binding]; other site 405532001695 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 405532001696 Citrate transporter; Region: CitMHS; pfam03600 405532001697 hypothetical protein; Provisional; Region: PRK12784 405532001698 NosL; Region: NosL; cl01769 405532001699 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405532001700 Ankyrin repeat; Region: Ank; pfam00023 405532001701 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405532001702 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405532001703 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 405532001704 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405532001705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532001706 Walker A/P-loop; other site 405532001707 ATP binding site [chemical binding]; other site 405532001708 Q-loop/lid; other site 405532001709 ABC transporter signature motif; other site 405532001710 Walker B; other site 405532001711 D-loop; other site 405532001712 H-loop/switch region; other site 405532001713 TOBE domain; Region: TOBE_2; pfam08402 405532001714 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 405532001715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532001716 dimer interface [polypeptide binding]; other site 405532001717 conserved gate region; other site 405532001718 putative PBP binding loops; other site 405532001719 ABC-ATPase subunit interface; other site 405532001720 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405532001721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405532001722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532001723 dimer interface [polypeptide binding]; other site 405532001724 conserved gate region; other site 405532001725 putative PBP binding loops; other site 405532001726 ABC-ATPase subunit interface; other site 405532001727 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 405532001728 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405532001729 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532001730 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 405532001731 active site 405532001732 metal binding site [ion binding]; metal-binding site 405532001733 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532001734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532001735 active site 405532001736 phosphorylation site [posttranslational modification] 405532001737 intermolecular recognition site; other site 405532001738 dimerization interface [polypeptide binding]; other site 405532001739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532001740 DNA binding site [nucleotide binding] 405532001741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532001742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532001743 dimer interface [polypeptide binding]; other site 405532001744 phosphorylation site [posttranslational modification] 405532001745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532001746 ATP binding site [chemical binding]; other site 405532001747 Mg2+ binding site [ion binding]; other site 405532001748 G-X-G motif; other site 405532001749 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405532001750 putative active site [active] 405532001751 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 405532001752 Cache domain; Region: Cache_1; pfam02743 405532001753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532001754 dimerization interface [polypeptide binding]; other site 405532001755 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532001756 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532001757 dimer interface [polypeptide binding]; other site 405532001758 putative CheW interface [polypeptide binding]; other site 405532001759 sensory histidine kinase DcuS; Provisional; Region: PRK11086 405532001760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532001761 ATP binding site [chemical binding]; other site 405532001762 Mg2+ binding site [ion binding]; other site 405532001763 G-X-G motif; other site 405532001764 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405532001765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532001766 active site 405532001767 phosphorylation site [posttranslational modification] 405532001768 intermolecular recognition site; other site 405532001769 dimerization interface [polypeptide binding]; other site 405532001770 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 405532001771 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 405532001772 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405532001773 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 405532001774 putative NAD(P) binding site [chemical binding]; other site 405532001775 EamA-like transporter family; Region: EamA; pfam00892 405532001776 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405532001777 EamA-like transporter family; Region: EamA; pfam00892 405532001778 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405532001779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532001780 DNA-binding site [nucleotide binding]; DNA binding site 405532001781 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532001782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532001783 homodimer interface [polypeptide binding]; other site 405532001784 catalytic residue [active] 405532001785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405532001786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532001787 Coenzyme A binding pocket [chemical binding]; other site 405532001788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532001789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532001790 dimerization interface [polypeptide binding]; other site 405532001791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532001792 dimer interface [polypeptide binding]; other site 405532001793 phosphorylation site [posttranslational modification] 405532001794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532001795 ATP binding site [chemical binding]; other site 405532001796 Mg2+ binding site [ion binding]; other site 405532001797 G-X-G motif; other site 405532001798 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532001799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532001800 active site 405532001801 phosphorylation site [posttranslational modification] 405532001802 intermolecular recognition site; other site 405532001803 dimerization interface [polypeptide binding]; other site 405532001804 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532001805 DNA binding site [nucleotide binding] 405532001806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405532001807 Arrestin_N terminal like; Region: LDB19; pfam13002 405532001808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532001809 Coenzyme A binding pocket [chemical binding]; other site 405532001810 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 405532001811 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 405532001812 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405532001813 catalytic loop [active] 405532001814 iron binding site [ion binding]; other site 405532001815 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 405532001816 4Fe-4S binding domain; Region: Fer4; pfam00037 405532001817 4Fe-4S binding domain; Region: Fer4; pfam00037 405532001818 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 405532001819 [4Fe-4S] binding site [ion binding]; other site 405532001820 molybdopterin cofactor binding site; other site 405532001821 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 405532001822 molybdopterin cofactor binding site; other site 405532001823 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405532001824 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 405532001825 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405532001826 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 405532001827 putative active site [active] 405532001828 catalytic site [active] 405532001829 putative metal binding site [ion binding]; other site 405532001830 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 405532001831 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 405532001832 hexamer interface [polypeptide binding]; other site 405532001833 ligand binding site [chemical binding]; other site 405532001834 putative active site [active] 405532001835 NAD(P) binding site [chemical binding]; other site 405532001836 amino acid transporter; Region: 2A0306; TIGR00909 405532001837 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405532001838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405532001839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532001840 dimerization interface [polypeptide binding]; other site 405532001841 putative DNA binding site [nucleotide binding]; other site 405532001842 putative Zn2+ binding site [ion binding]; other site 405532001843 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405532001844 metal-binding site [ion binding] 405532001845 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405532001846 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405532001847 metal-binding site [ion binding] 405532001848 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405532001849 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405532001850 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 405532001851 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 405532001852 active site 405532001853 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532001854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532001855 non-specific DNA binding site [nucleotide binding]; other site 405532001856 salt bridge; other site 405532001857 sequence-specific DNA binding site [nucleotide binding]; other site 405532001858 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405532001859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532001860 binding surface 405532001861 TPR motif; other site 405532001862 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405532001863 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405532001864 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405532001865 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405532001866 active site 405532001867 Zn binding site [ion binding]; other site 405532001868 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405532001869 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405532001870 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 405532001871 VanW like protein; Region: VanW; pfam04294 405532001872 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405532001873 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405532001874 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405532001875 Nucleoside recognition; Region: Gate; pfam07670 405532001876 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405532001877 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532001878 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 405532001879 putative metal binding site [ion binding]; other site 405532001880 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405532001881 Domain of unknown function DUF21; Region: DUF21; pfam01595 405532001882 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405532001883 Transporter associated domain; Region: CorC_HlyC; smart01091 405532001884 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 405532001885 Aspartase; Region: Aspartase; cd01357 405532001886 active sites [active] 405532001887 tetramer interface [polypeptide binding]; other site 405532001888 L-lactate permease; Region: Lactate_perm; cl00701 405532001889 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 405532001890 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532001891 dimerization interface [polypeptide binding]; other site 405532001892 putative Zn2+ binding site [ion binding]; other site 405532001893 putative DNA binding site [nucleotide binding]; other site 405532001894 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 405532001895 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 405532001896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532001897 putative substrate translocation pore; other site 405532001898 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405532001899 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405532001900 siderophore binding site; other site 405532001901 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405532001902 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532001903 ABC-ATPase subunit interface; other site 405532001904 dimer interface [polypeptide binding]; other site 405532001905 putative PBP binding regions; other site 405532001906 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405532001907 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532001908 ABC-ATPase subunit interface; other site 405532001909 dimer interface [polypeptide binding]; other site 405532001910 putative PBP binding regions; other site 405532001911 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405532001912 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405532001913 Walker A/P-loop; other site 405532001914 ATP binding site [chemical binding]; other site 405532001915 Q-loop/lid; other site 405532001916 ABC transporter signature motif; other site 405532001917 Walker B; other site 405532001918 D-loop; other site 405532001919 H-loop/switch region; other site 405532001920 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405532001921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532001922 S-adenosylmethionine binding site [chemical binding]; other site 405532001923 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405532001924 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405532001925 substrate-cofactor binding pocket; other site 405532001926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532001927 catalytic residue [active] 405532001928 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405532001929 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 405532001930 NAD binding site [chemical binding]; other site 405532001931 homodimer interface [polypeptide binding]; other site 405532001932 active site 405532001933 putative substrate binding site [chemical binding]; other site 405532001934 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405532001935 nudix motif; other site 405532001936 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 405532001937 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 405532001938 metal ion-dependent adhesion site (MIDAS); other site 405532001939 MoxR-like ATPases [General function prediction only]; Region: COG0714 405532001940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532001941 Walker A motif; other site 405532001942 ATP binding site [chemical binding]; other site 405532001943 Walker B motif; other site 405532001944 arginine finger; other site 405532001945 cardiolipin synthetase; Reviewed; Region: PRK12452 405532001946 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405532001947 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405532001948 putative active site [active] 405532001949 catalytic site [active] 405532001950 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405532001951 putative active site [active] 405532001952 catalytic site [active] 405532001953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532001954 PAS domain; Region: PAS_9; pfam13426 405532001955 putative active site [active] 405532001956 heme pocket [chemical binding]; other site 405532001957 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405532001958 metal binding site [ion binding]; metal-binding site 405532001959 active site 405532001960 I-site; other site 405532001961 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405532001962 putrescine transporter; Provisional; Region: potE; PRK10655 405532001963 Spore germination protein; Region: Spore_permease; cl17796 405532001964 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532001965 DNA-binding site [nucleotide binding]; DNA binding site 405532001966 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 405532001967 UTRA domain; Region: UTRA; pfam07702 405532001968 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 405532001969 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405532001970 active site turn [active] 405532001971 phosphorylation site [posttranslational modification] 405532001972 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405532001973 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405532001974 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405532001975 Ca binding site [ion binding]; other site 405532001976 active site 405532001977 catalytic site [active] 405532001978 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405532001979 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405532001980 Spore germination protein; Region: Spore_permease; cl17796 405532001981 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405532001982 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405532001983 active site 405532001984 ATP binding site [chemical binding]; other site 405532001985 substrate binding site [chemical binding]; other site 405532001986 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405532001987 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 405532001988 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405532001989 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405532001990 Walker A/P-loop; other site 405532001991 ATP binding site [chemical binding]; other site 405532001992 Q-loop/lid; other site 405532001993 ABC transporter signature motif; other site 405532001994 Walker B; other site 405532001995 D-loop; other site 405532001996 H-loop/switch region; other site 405532001997 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405532001998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405532001999 substrate binding pocket [chemical binding]; other site 405532002000 membrane-bound complex binding site; other site 405532002001 hinge residues; other site 405532002002 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405532002003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532002004 dimer interface [polypeptide binding]; other site 405532002005 conserved gate region; other site 405532002006 putative PBP binding loops; other site 405532002007 ABC-ATPase subunit interface; other site 405532002008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532002009 dimer interface [polypeptide binding]; other site 405532002010 conserved gate region; other site 405532002011 putative PBP binding loops; other site 405532002012 ABC-ATPase subunit interface; other site 405532002013 S-methylmethionine transporter; Provisional; Region: PRK11387 405532002014 OsmC-like protein; Region: OsmC; pfam02566 405532002015 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 405532002016 nucleotide binding site/active site [active] 405532002017 HIT family signature motif; other site 405532002018 catalytic residue [active] 405532002019 RNA polymerase sigma factor; Provisional; Region: PRK12542 405532002020 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532002021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532002022 DNA binding residues [nucleotide binding] 405532002023 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 405532002024 Predicted transcriptional regulator [Transcription]; Region: COG2378 405532002025 HTH domain; Region: HTH_11; pfam08279 405532002026 WYL domain; Region: WYL; pfam13280 405532002027 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405532002028 RibD C-terminal domain; Region: RibD_C; cl17279 405532002029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532002030 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532002031 dimerization interface [polypeptide binding]; other site 405532002032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532002033 dimer interface [polypeptide binding]; other site 405532002034 phosphorylation site [posttranslational modification] 405532002035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532002036 ATP binding site [chemical binding]; other site 405532002037 Mg2+ binding site [ion binding]; other site 405532002038 G-X-G motif; other site 405532002039 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532002040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532002041 active site 405532002042 phosphorylation site [posttranslational modification] 405532002043 intermolecular recognition site; other site 405532002044 dimerization interface [polypeptide binding]; other site 405532002045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532002046 DNA binding site [nucleotide binding] 405532002047 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 405532002048 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 405532002049 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 405532002050 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405532002051 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405532002052 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405532002053 Ligand Binding Site [chemical binding]; other site 405532002054 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 405532002055 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 405532002056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002057 putative substrate translocation pore; other site 405532002058 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532002059 MarR family; Region: MarR; pfam01047 405532002060 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405532002061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002062 putative substrate translocation pore; other site 405532002063 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405532002064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405532002065 DNA binding site [nucleotide binding] 405532002066 domain linker motif; other site 405532002067 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 405532002068 dimerization interface [polypeptide binding]; other site 405532002069 ligand binding site [chemical binding]; other site 405532002070 sodium binding site [ion binding]; other site 405532002071 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405532002072 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 405532002073 substrate binding site [chemical binding]; other site 405532002074 dimer interface [polypeptide binding]; other site 405532002075 ATP binding site [chemical binding]; other site 405532002076 D-ribose pyranase; Provisional; Region: PRK11797 405532002077 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405532002078 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405532002079 Walker A/P-loop; other site 405532002080 ATP binding site [chemical binding]; other site 405532002081 Q-loop/lid; other site 405532002082 ABC transporter signature motif; other site 405532002083 Walker B; other site 405532002084 D-loop; other site 405532002085 H-loop/switch region; other site 405532002086 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405532002087 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405532002088 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405532002089 TM-ABC transporter signature motif; other site 405532002090 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 405532002091 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 405532002092 ligand binding site [chemical binding]; other site 405532002093 dimerization interface [polypeptide binding]; other site 405532002094 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405532002095 active site 405532002096 intersubunit interactions; other site 405532002097 catalytic residue [active] 405532002098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405532002099 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405532002100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532002102 putative substrate translocation pore; other site 405532002103 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405532002104 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 405532002105 putative NAD(P) binding site [chemical binding]; other site 405532002106 catalytic Zn binding site [ion binding]; other site 405532002107 Ion channel; Region: Ion_trans_2; pfam07885 405532002108 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 405532002109 Zn binding site [ion binding]; other site 405532002110 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 405532002111 putative catalytic site [active] 405532002112 metal binding site A [ion binding]; metal-binding site 405532002113 phosphate binding site [ion binding]; other site 405532002114 metal binding site C [ion binding]; metal-binding site 405532002115 metal binding site B [ion binding]; metal-binding site 405532002116 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 405532002117 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 405532002118 dimer interface [polypeptide binding]; other site 405532002119 active site 405532002120 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405532002121 substrate binding site [chemical binding]; other site 405532002122 catalytic residue [active] 405532002123 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 405532002124 FAD binding domain; Region: FAD_binding_4; pfam01565 405532002125 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 405532002126 VanZ like family; Region: VanZ; pfam04892 405532002127 RDD family; Region: RDD; pfam06271 405532002128 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 405532002129 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 405532002130 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532002131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532002132 dimer interface [polypeptide binding]; other site 405532002133 putative CheW interface [polypeptide binding]; other site 405532002134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405532002135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405532002136 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532002137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532002138 non-specific DNA binding site [nucleotide binding]; other site 405532002139 salt bridge; other site 405532002140 sequence-specific DNA binding site [nucleotide binding]; other site 405532002141 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 405532002142 active site 405532002143 catalytic site [active] 405532002144 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 405532002145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002146 POT family; Region: PTR2; cl17359 405532002147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002148 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405532002149 Archaeal flagella protein; Region: Arch_fla_DE; cl01322 405532002150 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 405532002151 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 405532002152 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 405532002153 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405532002154 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 405532002155 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405532002156 DNA binding residues [nucleotide binding] 405532002157 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 405532002158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405532002159 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405532002160 Probable transposase; Region: OrfB_IS605; pfam01385 405532002161 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405532002162 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532002163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532002164 non-specific DNA binding site [nucleotide binding]; other site 405532002165 salt bridge; other site 405532002166 sequence-specific DNA binding site [nucleotide binding]; other site 405532002167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532002168 Coenzyme A binding pocket [chemical binding]; other site 405532002169 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 405532002170 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405532002171 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405532002172 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405532002173 TrkA-N domain; Region: TrkA_N; pfam02254 405532002174 TrkA-C domain; Region: TrkA_C; pfam02080 405532002175 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 405532002176 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 405532002177 Subunit I/III interface [polypeptide binding]; other site 405532002178 Subunit III/IV interface [polypeptide binding]; other site 405532002179 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 405532002180 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 405532002181 D-pathway; other site 405532002182 Putative ubiquinol binding site [chemical binding]; other site 405532002183 Low-spin heme (heme b) binding site [chemical binding]; other site 405532002184 Putative water exit pathway; other site 405532002185 Binuclear center (heme o3/CuB) [ion binding]; other site 405532002186 K-pathway; other site 405532002187 Putative proton exit pathway; other site 405532002188 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 405532002189 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 405532002190 S-methylmethionine transporter; Provisional; Region: PRK11387 405532002191 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405532002192 putative active site [active] 405532002193 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405532002194 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 405532002195 metal binding site [ion binding]; metal-binding site 405532002196 dimer interface [polypeptide binding]; other site 405532002197 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 405532002198 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 405532002199 Na binding site [ion binding]; other site 405532002200 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405532002201 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 405532002202 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405532002203 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405532002204 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 405532002205 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 405532002206 G1 box; other site 405532002207 GTP/Mg2+ binding site [chemical binding]; other site 405532002208 Switch I region; other site 405532002209 G2 box; other site 405532002210 G3 box; other site 405532002211 Switch II region; other site 405532002212 G4 box; other site 405532002213 G5 box; other site 405532002214 FeoA domain; Region: FeoA; pfam04023 405532002215 phosphate binding protein; Region: ptsS_2; TIGR02136 405532002216 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405532002217 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405532002218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532002219 dimer interface [polypeptide binding]; other site 405532002220 conserved gate region; other site 405532002221 putative PBP binding loops; other site 405532002222 ABC-ATPase subunit interface; other site 405532002223 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 405532002224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532002225 dimer interface [polypeptide binding]; other site 405532002226 conserved gate region; other site 405532002227 putative PBP binding loops; other site 405532002228 ABC-ATPase subunit interface; other site 405532002229 AAA domain; Region: AAA_33; pfam13671 405532002230 AAA domain; Region: AAA_17; pfam13207 405532002231 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 405532002232 Protein export membrane protein; Region: SecD_SecF; cl14618 405532002233 FOG: CBS domain [General function prediction only]; Region: COG0517 405532002234 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 405532002235 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 405532002236 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 405532002237 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532002238 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532002239 Bacterial SH3 domain; Region: SH3_3; cl17532 405532002240 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405532002241 Peptidase family M23; Region: Peptidase_M23; pfam01551 405532002242 Putative transcription activator [Transcription]; Region: TenA; COG0819 405532002243 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405532002244 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405532002245 Walker A/P-loop; other site 405532002246 ATP binding site [chemical binding]; other site 405532002247 Q-loop/lid; other site 405532002248 ABC transporter signature motif; other site 405532002249 Walker B; other site 405532002250 D-loop; other site 405532002251 H-loop/switch region; other site 405532002252 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405532002253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532002254 dimer interface [polypeptide binding]; other site 405532002255 conserved gate region; other site 405532002256 putative PBP binding loops; other site 405532002257 ABC-ATPase subunit interface; other site 405532002258 NMT1/THI5 like; Region: NMT1; pfam09084 405532002259 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 405532002260 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 405532002261 thiamine phosphate binding site [chemical binding]; other site 405532002262 active site 405532002263 pyrophosphate binding site [ion binding]; other site 405532002264 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 405532002265 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405532002266 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 405532002267 thiS-thiF/thiG interaction site; other site 405532002268 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 405532002269 ThiS interaction site; other site 405532002270 putative active site [active] 405532002271 tetramer interface [polypeptide binding]; other site 405532002272 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 405532002273 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405532002274 ATP binding site [chemical binding]; other site 405532002275 substrate interface [chemical binding]; other site 405532002276 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405532002277 dimer interface [polypeptide binding]; other site 405532002278 substrate binding site [chemical binding]; other site 405532002279 ATP binding site [chemical binding]; other site 405532002280 ydaO/yuaA leader 405532002281 ydaO/yuaA leader 405532002282 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 405532002283 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 405532002284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405532002285 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405532002286 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 405532002287 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 405532002288 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 405532002289 Ligand Binding Site [chemical binding]; other site 405532002290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532002292 putative substrate translocation pore; other site 405532002293 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532002294 MarR family; Region: MarR; pfam01047 405532002295 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405532002296 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405532002297 active site 405532002298 nucleophile elbow; other site 405532002299 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405532002300 short chain dehydrogenase; Provisional; Region: PRK06701 405532002301 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 405532002302 NAD binding site [chemical binding]; other site 405532002303 metal binding site [ion binding]; metal-binding site 405532002304 active site 405532002305 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405532002306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405532002307 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405532002308 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 405532002309 putative substrate binding site [chemical binding]; other site 405532002310 putative ATP binding site [chemical binding]; other site 405532002311 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 405532002312 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 405532002313 substrate binding [chemical binding]; other site 405532002314 active site 405532002315 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 405532002316 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 405532002317 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405532002318 active site turn [active] 405532002319 phosphorylation site [posttranslational modification] 405532002320 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405532002321 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405532002322 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405532002323 DNA binding site [nucleotide binding] 405532002324 domain linker motif; other site 405532002325 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 405532002326 dimerization interface [polypeptide binding]; other site 405532002327 ligand binding site [chemical binding]; other site 405532002328 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 405532002329 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405532002330 catalytic residues [active] 405532002331 putative disulfide oxidoreductase; Provisional; Region: PRK03113 405532002332 YhdB-like protein; Region: YhdB; pfam14148 405532002333 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 405532002334 Spore germination protein; Region: Spore_permease; pfam03845 405532002335 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405532002336 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405532002337 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405532002338 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 405532002339 putative FMN binding site [chemical binding]; other site 405532002340 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 405532002341 SpoVR like protein; Region: SpoVR; pfam04293 405532002342 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 405532002343 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 405532002344 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532002345 putative DNA binding site [nucleotide binding]; other site 405532002346 putative Zn2+ binding site [ion binding]; other site 405532002347 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 405532002348 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 405532002349 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 405532002350 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532002351 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405532002352 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 405532002353 active site residue [active] 405532002354 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 405532002355 putative homodimer interface [polypeptide binding]; other site 405532002356 putative homotetramer interface [polypeptide binding]; other site 405532002357 putative metal binding site [ion binding]; other site 405532002358 putative homodimer-homodimer interface [polypeptide binding]; other site 405532002359 putative allosteric switch controlling residues; other site 405532002360 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 405532002361 CPxP motif; other site 405532002362 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405532002363 active site residue [active] 405532002364 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 405532002365 active site residue [active] 405532002366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532002367 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 405532002368 CPxP motif; other site 405532002369 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405532002370 active site residue [active] 405532002371 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 405532002372 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405532002373 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405532002374 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 405532002375 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 405532002376 NADP binding site [chemical binding]; other site 405532002377 dimer interface [polypeptide binding]; other site 405532002378 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 405532002379 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405532002380 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405532002381 PhoU domain; Region: PhoU; pfam01895 405532002382 PhoU domain; Region: PhoU; pfam01895 405532002383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532002385 putative substrate translocation pore; other site 405532002386 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405532002387 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405532002388 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 405532002389 HTH domain; Region: HTH_11; pfam08279 405532002390 Mga helix-turn-helix domain; Region: Mga; pfam05043 405532002391 PRD domain; Region: PRD; pfam00874 405532002392 PRD domain; Region: PRD; pfam00874 405532002393 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 405532002394 active site 405532002395 P-loop; other site 405532002396 phosphorylation site [posttranslational modification] 405532002397 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405532002398 active site 405532002399 phosphorylation site [posttranslational modification] 405532002400 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405532002401 active site 405532002402 methionine cluster; other site 405532002403 phosphorylation site [posttranslational modification] 405532002404 metal binding site [ion binding]; metal-binding site 405532002405 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405532002406 active site 405532002407 P-loop; other site 405532002408 phosphorylation site [posttranslational modification] 405532002409 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405532002410 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405532002411 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405532002412 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405532002413 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532002414 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532002415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405532002416 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405532002417 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405532002418 FtsX-like permease family; Region: FtsX; pfam02687 405532002419 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532002420 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532002421 Walker A/P-loop; other site 405532002422 ATP binding site [chemical binding]; other site 405532002423 Q-loop/lid; other site 405532002424 ABC transporter signature motif; other site 405532002425 Walker B; other site 405532002426 D-loop; other site 405532002427 H-loop/switch region; other site 405532002428 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405532002429 HlyD family secretion protein; Region: HlyD_3; pfam13437 405532002430 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 405532002431 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 405532002432 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405532002433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405532002434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532002435 dimer interface [polypeptide binding]; other site 405532002436 conserved gate region; other site 405532002437 ABC-ATPase subunit interface; other site 405532002438 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405532002439 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 405532002440 dimanganese center [ion binding]; other site 405532002441 CotJB protein; Region: CotJB; pfam12652 405532002442 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 405532002443 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532002444 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405532002445 active site 405532002446 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405532002447 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405532002448 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 405532002449 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 405532002450 putative DNA binding site [nucleotide binding]; other site 405532002451 putative homodimer interface [polypeptide binding]; other site 405532002452 yybP-ykoY leader 405532002453 Uncharacterized conserved protein [Function unknown]; Region: COG3339 405532002454 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405532002455 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405532002456 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405532002457 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405532002458 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405532002459 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532002460 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405532002461 active site 405532002462 metal binding site [ion binding]; metal-binding site 405532002463 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405532002464 Interdomain contacts; other site 405532002465 Cytokine receptor motif; other site 405532002466 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 405532002467 amino acid transporter; Region: 2A0306; TIGR00909 405532002468 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405532002469 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405532002470 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405532002471 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405532002472 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405532002473 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405532002474 putative active site [active] 405532002475 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 405532002476 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 405532002477 putative active site [active] 405532002478 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405532002479 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 405532002480 active site turn [active] 405532002481 phosphorylation site [posttranslational modification] 405532002482 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405532002483 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405532002484 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405532002485 DoxX; Region: DoxX; pfam07681 405532002486 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 405532002487 hypothetical protein; Provisional; Region: PRK06770 405532002488 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532002489 EamA-like transporter family; Region: EamA; pfam00892 405532002490 EamA-like transporter family; Region: EamA; pfam00892 405532002491 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405532002492 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 405532002493 AsnC family; Region: AsnC_trans_reg; pfam01037 405532002494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532002495 Coenzyme A binding pocket [chemical binding]; other site 405532002496 short chain dehydrogenase; Provisional; Region: PRK06138 405532002497 classical (c) SDRs; Region: SDR_c; cd05233 405532002498 NAD(P) binding site [chemical binding]; other site 405532002499 active site 405532002500 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405532002501 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 405532002502 DNA binding residues [nucleotide binding] 405532002503 putative dimer interface [polypeptide binding]; other site 405532002504 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405532002505 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405532002506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532002507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532002508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532002509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002511 Predicted transcriptional regulators [Transcription]; Region: COG1733 405532002512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532002513 dimerization interface [polypeptide binding]; other site 405532002514 putative DNA binding site [nucleotide binding]; other site 405532002515 putative Zn2+ binding site [ion binding]; other site 405532002516 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 405532002517 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405532002518 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405532002519 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 405532002520 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 405532002521 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 405532002522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002524 putative substrate translocation pore; other site 405532002525 intracellular protease, PfpI family; Region: PfpI; TIGR01382 405532002526 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 405532002527 proposed catalytic triad [active] 405532002528 conserved cys residue [active] 405532002529 hydroperoxidase II; Provisional; Region: katE; PRK11249 405532002530 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 405532002531 tetramer interface [polypeptide binding]; other site 405532002532 heme binding pocket [chemical binding]; other site 405532002533 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 405532002534 domain interactions; other site 405532002535 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405532002536 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405532002537 Spore germination protein; Region: Spore_permease; cl17796 405532002538 Lysine riboswitch 405532002539 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 405532002540 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 405532002541 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 405532002542 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 405532002543 tetrameric interface [polypeptide binding]; other site 405532002544 activator binding site; other site 405532002545 NADP binding site [chemical binding]; other site 405532002546 substrate binding site [chemical binding]; other site 405532002547 catalytic residues [active] 405532002548 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532002549 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 405532002550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532002551 Walker A/P-loop; other site 405532002552 ATP binding site [chemical binding]; other site 405532002553 Q-loop/lid; other site 405532002554 ABC transporter signature motif; other site 405532002555 Walker B; other site 405532002556 D-loop; other site 405532002557 H-loop/switch region; other site 405532002558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532002559 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 405532002560 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405532002561 Walker A/P-loop; other site 405532002562 ATP binding site [chemical binding]; other site 405532002563 Q-loop/lid; other site 405532002564 ABC transporter signature motif; other site 405532002565 Walker B; other site 405532002566 D-loop; other site 405532002567 H-loop/switch region; other site 405532002568 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405532002569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405532002570 substrate binding pocket [chemical binding]; other site 405532002571 membrane-bound complex binding site; other site 405532002572 hinge residues; other site 405532002573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532002574 dimer interface [polypeptide binding]; other site 405532002575 conserved gate region; other site 405532002576 putative PBP binding loops; other site 405532002577 ABC-ATPase subunit interface; other site 405532002578 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405532002579 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405532002580 Walker A/P-loop; other site 405532002581 ATP binding site [chemical binding]; other site 405532002582 Q-loop/lid; other site 405532002583 ABC transporter signature motif; other site 405532002584 Walker B; other site 405532002585 D-loop; other site 405532002586 H-loop/switch region; other site 405532002587 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405532002588 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 405532002589 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 405532002590 Protein of unknown function (DUF445); Region: DUF445; pfam04286 405532002591 hypothetical protein; Provisional; Region: PRK13676 405532002592 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405532002593 active site 405532002594 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 405532002595 acetolactate synthase; Reviewed; Region: PRK08617 405532002596 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405532002597 PYR/PP interface [polypeptide binding]; other site 405532002598 dimer interface [polypeptide binding]; other site 405532002599 TPP binding site [chemical binding]; other site 405532002600 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405532002601 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 405532002602 TPP-binding site [chemical binding]; other site 405532002603 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 405532002604 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 405532002605 active site 405532002606 DNA binding site [nucleotide binding] 405532002607 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 405532002608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 405532002609 active site 405532002610 motif I; other site 405532002611 motif II; other site 405532002612 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405532002613 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 405532002614 Cna protein B-type domain; Region: Cna_B; pfam05738 405532002615 Cna protein B-type domain; Region: Cna_B; pfam05738 405532002616 Cna protein B-type domain; Region: Cna_B; pfam05738 405532002617 Cna protein B-type domain; Region: Cna_B; pfam05738 405532002618 Cna protein B-type domain; Region: Cna_B; pfam05738 405532002619 Cna protein B-type domain; Region: Cna_B; pfam05738 405532002620 Cna protein B-type domain; Region: Cna_B; pfam05738 405532002621 Cna protein B-type domain; Region: Cna_B; pfam05738 405532002622 Cna protein B-type domain; Region: Cna_B; pfam05738 405532002623 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405532002624 amidase catalytic site [active] 405532002625 Zn binding residues [ion binding]; other site 405532002626 substrate binding site [chemical binding]; other site 405532002627 S-layer homology domain; Region: SLH; pfam00395 405532002628 S-layer homology domain; Region: SLH; pfam00395 405532002629 S-layer homology domain; Region: SLH; pfam00395 405532002630 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 405532002631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532002632 FeS/SAM binding site; other site 405532002633 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 405532002634 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405532002635 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 405532002636 acyl-activating enzyme (AAE) consensus motif; other site 405532002637 acyl-activating enzyme (AAE) consensus motif; other site 405532002638 putative AMP binding site [chemical binding]; other site 405532002639 putative active site [active] 405532002640 putative CoA binding site [chemical binding]; other site 405532002641 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 405532002642 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405532002643 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405532002644 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405532002645 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405532002646 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 405532002647 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 405532002648 S-layer homology domain; Region: SLH; pfam00395 405532002649 S-layer homology domain; Region: SLH; pfam00395 405532002650 S-layer homology domain; Region: SLH; pfam00395 405532002651 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 405532002652 O-Antigen ligase; Region: Wzy_C; cl04850 405532002653 enoyl-CoA hydratase; Provisional; Region: PRK07659 405532002654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405532002655 substrate binding site [chemical binding]; other site 405532002656 oxyanion hole (OAH) forming residues; other site 405532002657 trimer interface [polypeptide binding]; other site 405532002658 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 405532002659 metal binding site [ion binding]; metal-binding site 405532002660 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405532002661 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 405532002662 putative oligomer interface [polypeptide binding]; other site 405532002663 putative active site [active] 405532002664 metal binding site [ion binding]; metal-binding site 405532002665 S-layer homology domain; Region: SLH; pfam00395 405532002666 S-layer homology domain; Region: SLH; pfam00395 405532002667 S-layer homology domain; Region: SLH; pfam00395 405532002668 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405532002669 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405532002670 active site 405532002671 metal binding site [ion binding]; metal-binding site 405532002672 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 405532002673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532002674 S-adenosylmethionine binding site [chemical binding]; other site 405532002675 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 405532002676 proline racemase; Provisional; Region: PRK13969 405532002677 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405532002678 ornithine cyclodeaminase; Validated; Region: PRK08618 405532002679 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405532002680 NAD(P) binding site [chemical binding]; other site 405532002681 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405532002682 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 405532002683 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405532002684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532002685 dimer interface [polypeptide binding]; other site 405532002686 conserved gate region; other site 405532002687 putative PBP binding loops; other site 405532002688 ABC-ATPase subunit interface; other site 405532002689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405532002690 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405532002691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532002692 dimer interface [polypeptide binding]; other site 405532002693 conserved gate region; other site 405532002694 putative PBP binding loops; other site 405532002695 ABC-ATPase subunit interface; other site 405532002696 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405532002697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405532002698 Walker A/P-loop; other site 405532002699 ATP binding site [chemical binding]; other site 405532002700 Q-loop/lid; other site 405532002701 ABC transporter signature motif; other site 405532002702 Walker B; other site 405532002703 D-loop; other site 405532002704 H-loop/switch region; other site 405532002705 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405532002706 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 405532002707 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405532002708 Walker A/P-loop; other site 405532002709 ATP binding site [chemical binding]; other site 405532002710 Q-loop/lid; other site 405532002711 ABC transporter signature motif; other site 405532002712 Walker B; other site 405532002713 D-loop; other site 405532002714 H-loop/switch region; other site 405532002715 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405532002716 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 405532002717 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 405532002718 catalytic residues [active] 405532002719 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 405532002720 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532002721 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 405532002722 Walker A/P-loop; other site 405532002723 ATP binding site [chemical binding]; other site 405532002724 Q-loop/lid; other site 405532002725 ABC transporter signature motif; other site 405532002726 Walker B; other site 405532002727 D-loop; other site 405532002728 H-loop/switch region; other site 405532002729 FtsX-like permease family; Region: FtsX; pfam02687 405532002730 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 405532002731 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 405532002732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 405532002733 putative Zn2+ binding site [ion binding]; other site 405532002734 putative DNA binding site [nucleotide binding]; other site 405532002735 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405532002736 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532002737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532002738 non-specific DNA binding site [nucleotide binding]; other site 405532002739 salt bridge; other site 405532002740 sequence-specific DNA binding site [nucleotide binding]; other site 405532002741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 405532002742 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 405532002743 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 405532002744 LXG domain of WXG superfamily; Region: LXG; pfam04740 405532002745 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 405532002746 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 405532002747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002748 putative substrate translocation pore; other site 405532002749 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 405532002750 PAS domain; Region: PAS; smart00091 405532002751 putative active site [active] 405532002752 heme pocket [chemical binding]; other site 405532002753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532002754 ATP binding site [chemical binding]; other site 405532002755 Mg2+ binding site [ion binding]; other site 405532002756 G-X-G motif; other site 405532002757 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405532002758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532002759 active site 405532002760 phosphorylation site [posttranslational modification] 405532002761 intermolecular recognition site; other site 405532002762 dimerization interface [polypeptide binding]; other site 405532002763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 405532002764 Nuclease-related domain; Region: NERD; pfam08378 405532002765 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 405532002766 Family description; Region: UvrD_C_2; pfam13538 405532002767 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 405532002768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405532002769 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 405532002770 Protein of unknown function (DUF524); Region: DUF524; pfam04411 405532002771 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 405532002772 DNA methylase; Region: N6_N4_Mtase; pfam01555 405532002773 DNA methylase; Region: N6_N4_Mtase; pfam01555 405532002774 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405532002775 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 405532002776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405532002777 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 405532002778 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405532002779 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 405532002780 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 405532002781 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 405532002782 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 405532002783 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 405532002784 AAA ATPase domain; Region: AAA_15; pfam13175 405532002785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532002786 Walker A/P-loop; other site 405532002787 ATP binding site [chemical binding]; other site 405532002788 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 405532002789 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405532002790 replicative DNA helicase; Provisional; Region: PRK06749 405532002791 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405532002792 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405532002793 Walker A motif; other site 405532002794 ATP binding site [chemical binding]; other site 405532002795 Walker B motif; other site 405532002796 DNA binding loops [nucleotide binding] 405532002797 Predicted transcriptional regulators [Transcription]; Region: COG1378 405532002798 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405532002799 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405532002800 C-terminal domain interface [polypeptide binding]; other site 405532002801 sugar binding site [chemical binding]; other site 405532002802 hypothetical protein; Provisional; Region: PRK10621 405532002803 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405532002804 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532002805 EamA-like transporter family; Region: EamA; pfam00892 405532002806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532002807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532002808 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405532002809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002810 putative substrate translocation pore; other site 405532002811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532002812 hypothetical protein; Provisional; Region: PRK06770 405532002813 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532002814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532002815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532002816 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405532002817 putative pectinesterase; Region: PLN02432; cl01911 405532002818 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 405532002819 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 405532002820 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 405532002821 CGNR zinc finger; Region: zf-CGNR; pfam11706 405532002822 HPP family; Region: HPP; pfam04982 405532002823 YmzC-like protein; Region: YmzC; pfam14157 405532002824 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405532002825 MarR family; Region: MarR_2; pfam12802 405532002826 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 405532002827 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 405532002828 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405532002829 VanZ like family; Region: VanZ; pfam04892 405532002830 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 405532002831 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 405532002832 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 405532002833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532002834 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405532002835 dihydroxyacetone kinase; Provisional; Region: PRK14479 405532002836 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 405532002837 DAK2 domain; Region: Dak2; pfam02734 405532002838 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 405532002839 Bacterial SH3 domain; Region: SH3_3; cl17532 405532002840 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 405532002841 DAK2 domain; Region: Dak2; cl03685 405532002842 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532002843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532002844 non-specific DNA binding site [nucleotide binding]; other site 405532002845 salt bridge; other site 405532002846 sequence-specific DNA binding site [nucleotide binding]; other site 405532002847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405532002848 3D domain; Region: 3D; cl01439 405532002849 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405532002850 NlpC/P60 family; Region: NLPC_P60; pfam00877 405532002851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405532002852 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532002853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405532002854 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532002855 putative transposase OrfB; Reviewed; Region: PHA02517 405532002856 HTH-like domain; Region: HTH_21; pfam13276 405532002857 Integrase core domain; Region: rve; pfam00665 405532002858 Integrase core domain; Region: rve_2; pfam13333 405532002859 S-layer homology domain; Region: SLH; pfam00395 405532002860 S-layer homology domain; Region: SLH; pfam00395 405532002861 S-layer homology domain; Region: SLH; pfam00395 405532002862 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405532002863 hypothetical protein; Provisional; Region: PRK06770 405532002864 Putative zinc-finger; Region: zf-HC2; pfam13490 405532002865 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 405532002866 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 405532002867 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532002868 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532002869 DNA binding residues [nucleotide binding] 405532002870 Heat induced stress protein YflT; Region: YflT; pfam11181 405532002871 Predicted membrane protein [Function unknown]; Region: COG2261 405532002872 Probable transposase; Region: OrfB_IS605; pfam01385 405532002873 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405532002874 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405532002875 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 405532002876 anti sigma factor interaction site; other site 405532002877 regulatory phosphorylation site [posttranslational modification]; other site 405532002878 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 405532002879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532002880 ATP binding site [chemical binding]; other site 405532002881 Mg2+ binding site [ion binding]; other site 405532002882 G-X-G motif; other site 405532002883 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 405532002884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532002885 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405532002886 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532002887 DNA binding residues [nucleotide binding] 405532002888 Ferritin-like domain; Region: Ferritin; pfam00210 405532002889 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 405532002890 dinuclear metal binding motif [ion binding]; other site 405532002891 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 405532002892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532002893 active site 405532002894 phosphorylation site [posttranslational modification] 405532002895 intermolecular recognition site; other site 405532002896 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 405532002897 dimerization interface [polypeptide binding]; other site 405532002898 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 405532002899 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 405532002900 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 405532002901 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 405532002902 CHASE3 domain; Region: CHASE3; pfam05227 405532002903 GAF domain; Region: GAF; pfam01590 405532002904 GAF domain; Region: GAF_2; pfam13185 405532002905 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532002906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532002907 dimer interface [polypeptide binding]; other site 405532002908 phosphorylation site [posttranslational modification] 405532002909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532002910 ATP binding site [chemical binding]; other site 405532002911 Mg2+ binding site [ion binding]; other site 405532002912 G-X-G motif; other site 405532002913 Response regulator receiver domain; Region: Response_reg; pfam00072 405532002914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532002915 active site 405532002916 phosphorylation site [posttranslational modification] 405532002917 intermolecular recognition site; other site 405532002918 dimerization interface [polypeptide binding]; other site 405532002919 regulatory protein interface [polypeptide binding]; other site 405532002920 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 405532002921 regulatory phosphorylation site [posttranslational modification]; other site 405532002922 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 405532002923 hypothetical protein; Provisional; Region: PRK12856 405532002924 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 405532002925 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405532002926 NADP binding site [chemical binding]; other site 405532002927 dimer interface [polypeptide binding]; other site 405532002928 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 405532002929 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 405532002930 active site 405532002931 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 405532002932 YhzD-like protein; Region: YhzD; pfam14120 405532002933 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405532002934 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532002935 active site 405532002936 metal binding site [ion binding]; metal-binding site 405532002937 DNA binding site [nucleotide binding] 405532002938 AAA domain; Region: AAA_27; pfam13514 405532002939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532002940 Q-loop/lid; other site 405532002941 ABC transporter signature motif; other site 405532002942 Walker B; other site 405532002943 D-loop; other site 405532002944 H-loop/switch region; other site 405532002945 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 405532002946 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 405532002947 generic binding surface I; other site 405532002948 generic binding surface II; other site 405532002949 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532002950 Zn2+ binding site [ion binding]; other site 405532002951 Mg2+ binding site [ion binding]; other site 405532002952 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405532002953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532002954 Zn binding site [ion binding]; other site 405532002955 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405532002956 Zn binding site [ion binding]; other site 405532002957 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405532002958 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532002959 Zn binding site [ion binding]; other site 405532002960 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405532002961 Zn binding site [ion binding]; other site 405532002962 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405532002963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532002964 TPR motif; other site 405532002965 binding surface 405532002966 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532002967 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405532002968 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 405532002969 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405532002970 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405532002971 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 405532002972 Cupin; Region: Cupin_1; smart00835 405532002973 Cupin; Region: Cupin_1; smart00835 405532002974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532002975 non-specific DNA binding site [nucleotide binding]; other site 405532002976 salt bridge; other site 405532002977 sequence-specific DNA binding site [nucleotide binding]; other site 405532002978 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 405532002979 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 405532002980 amphipathic channel; other site 405532002981 Asn-Pro-Ala signature motifs; other site 405532002982 glycerol kinase; Provisional; Region: glpK; PRK00047 405532002983 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 405532002984 N- and C-terminal domain interface [polypeptide binding]; other site 405532002985 active site 405532002986 MgATP binding site [chemical binding]; other site 405532002987 catalytic site [active] 405532002988 metal binding site [ion binding]; metal-binding site 405532002989 glycerol binding site [chemical binding]; other site 405532002990 homotetramer interface [polypeptide binding]; other site 405532002991 homodimer interface [polypeptide binding]; other site 405532002992 FBP binding site [chemical binding]; other site 405532002993 protein IIAGlc interface [polypeptide binding]; other site 405532002994 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 405532002995 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532002996 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405532002997 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 405532002998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532002999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532003000 DNA binding residues [nucleotide binding] 405532003001 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 405532003002 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532003003 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 405532003004 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 405532003005 Part of AAA domain; Region: AAA_19; pfam13245 405532003006 Family description; Region: UvrD_C_2; pfam13538 405532003007 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 405532003008 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405532003009 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 405532003010 transcriptional regulator Hpr; Provisional; Region: PRK13777 405532003011 MarR family; Region: MarR; pfam01047 405532003012 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 405532003013 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 405532003014 HIT family signature motif; other site 405532003015 catalytic residue [active] 405532003016 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405532003017 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532003018 Walker A/P-loop; other site 405532003019 ATP binding site [chemical binding]; other site 405532003020 Q-loop/lid; other site 405532003021 ABC transporter signature motif; other site 405532003022 Walker B; other site 405532003023 D-loop; other site 405532003024 H-loop/switch region; other site 405532003025 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405532003026 EcsC protein family; Region: EcsC; pfam12787 405532003027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532003028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532003029 Uncharacterized conserved protein [Function unknown]; Region: COG3402 405532003030 Predicted membrane protein [Function unknown]; Region: COG3428 405532003031 Bacterial PH domain; Region: DUF304; pfam03703 405532003032 Bacterial PH domain; Region: DUF304; cl01348 405532003033 Bacterial PH domain; Region: DUF304; pfam03703 405532003034 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 405532003035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532003036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532003037 Collagen binding domain; Region: Collagen_bind; pfam05737 405532003038 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405532003039 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003040 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003041 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003042 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003043 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405532003044 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003045 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003046 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003047 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003048 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003049 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003050 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003051 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003052 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003053 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003054 Cna protein B-type domain; Region: Cna_B; pfam05738 405532003055 Biofilm formation and stress response factor; Region: BsmA; pfam10014 405532003056 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 405532003057 classical (c) SDRs; Region: SDR_c; cd05233 405532003058 NAD(P) binding site [chemical binding]; other site 405532003059 active site 405532003060 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405532003061 EamA-like transporter family; Region: EamA; pfam00892 405532003062 EamA-like transporter family; Region: EamA; pfam00892 405532003063 Uncharacterized conserved protein [Function unknown]; Region: COG3402 405532003064 Predicted membrane protein [Function unknown]; Region: COG3428 405532003065 Bacterial PH domain; Region: DUF304; pfam03703 405532003066 Bacterial PH domain; Region: DUF304; pfam03703 405532003067 Bacterial PH domain; Region: DUF304; pfam03703 405532003068 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405532003069 Transglycosylase; Region: Transgly; pfam00912 405532003070 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405532003071 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532003072 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 405532003073 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 405532003074 substrate binding site [chemical binding]; other site 405532003075 active site 405532003076 ferrochelatase; Provisional; Region: PRK12435 405532003077 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 405532003078 C-terminal domain interface [polypeptide binding]; other site 405532003079 active site 405532003080 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 405532003081 active site 405532003082 N-terminal domain interface [polypeptide binding]; other site 405532003083 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 405532003084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405532003085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532003086 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 405532003087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 405532003088 Fn3 associated; Region: Fn3_assoc; pfam13287 405532003089 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 405532003090 generic binding surface II; other site 405532003091 generic binding surface I; other site 405532003092 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 405532003093 putative active site [active] 405532003094 putative catalytic site [active] 405532003095 putative Mg binding site IVb [ion binding]; other site 405532003096 putative phosphate binding site [ion binding]; other site 405532003097 putative DNA binding site [nucleotide binding]; other site 405532003098 putative Mg binding site IVa [ion binding]; other site 405532003099 Penicillinase repressor; Region: Pencillinase_R; pfam03965 405532003100 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 405532003101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532003102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532003103 Predicted membrane protein [Function unknown]; Region: COG1511 405532003104 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405532003105 Predicted membrane protein [Function unknown]; Region: COG1511 405532003106 Domain of unknown function (DUF3508); Region: DUF3508; pfam12018 405532003107 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 405532003108 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 405532003109 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 405532003110 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405532003111 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 405532003112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532003113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532003114 Coenzyme A binding pocket [chemical binding]; other site 405532003115 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405532003116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405532003117 DNA binding site [nucleotide binding] 405532003118 domain linker motif; other site 405532003119 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405532003120 putative dimerization interface [polypeptide binding]; other site 405532003121 putative ligand binding site [chemical binding]; other site 405532003122 YhfH-like protein; Region: YhfH; pfam14149 405532003123 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 405532003124 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405532003125 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 405532003126 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 405532003127 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 405532003128 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 405532003129 acyl-activating enzyme (AAE) consensus motif; other site 405532003130 putative AMP binding site [chemical binding]; other site 405532003131 putative active site [active] 405532003132 putative CoA binding site [chemical binding]; other site 405532003133 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405532003134 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405532003135 substrate binding pocket [chemical binding]; other site 405532003136 membrane-bound complex binding site; other site 405532003137 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 405532003138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532003139 dimer interface [polypeptide binding]; other site 405532003140 conserved gate region; other site 405532003141 putative PBP binding loops; other site 405532003142 ABC-ATPase subunit interface; other site 405532003143 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 405532003144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532003145 dimer interface [polypeptide binding]; other site 405532003146 conserved gate region; other site 405532003147 putative PBP binding loops; other site 405532003148 ABC-ATPase subunit interface; other site 405532003149 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 405532003150 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 405532003151 Walker A/P-loop; other site 405532003152 ATP binding site [chemical binding]; other site 405532003153 Q-loop/lid; other site 405532003154 ABC transporter signature motif; other site 405532003155 Walker B; other site 405532003156 D-loop; other site 405532003157 H-loop/switch region; other site 405532003158 TOBE-like domain; Region: TOBE_3; pfam12857 405532003159 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 405532003160 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 405532003161 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 405532003162 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 405532003163 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 405532003164 RHS protein; Region: RHS; pfam03527 405532003165 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 405532003166 RHS protein; Region: RHS; pfam03527 405532003167 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 405532003168 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 405532003169 RHS protein; Region: RHS; pfam03527 405532003170 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 405532003171 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 405532003172 RNase E inhibitor protein; Provisional; Region: PRK11191 405532003173 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 405532003174 RHS protein; Region: RHS; pfam03527 405532003175 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 405532003176 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 405532003177 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 405532003178 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 405532003179 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 405532003180 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 405532003181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532003182 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532003183 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405532003184 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405532003185 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532003186 putative active site [active] 405532003187 putative metal binding site [ion binding]; other site 405532003188 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532003189 Zn2+ binding site [ion binding]; other site 405532003190 Mg2+ binding site [ion binding]; other site 405532003191 Poxvirus C7/F8A protein; Region: Pox_C7_F8A; cl17263 405532003192 Putative zinc-finger; Region: zf-HC2; pfam13490 405532003193 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 405532003194 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405532003195 RNA polymerase sigma factor; Provisional; Region: PRK12541 405532003196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532003197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532003198 DNA binding residues [nucleotide binding] 405532003199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532003200 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405532003201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532003202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405532003203 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532003204 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405532003205 active site 405532003206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532003207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532003208 dimer interface [polypeptide binding]; other site 405532003209 phosphorylation site [posttranslational modification] 405532003210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532003211 ATP binding site [chemical binding]; other site 405532003212 Mg2+ binding site [ion binding]; other site 405532003213 G-X-G motif; other site 405532003214 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532003215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532003216 active site 405532003217 phosphorylation site [posttranslational modification] 405532003218 intermolecular recognition site; other site 405532003219 dimerization interface [polypeptide binding]; other site 405532003220 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532003221 DNA binding site [nucleotide binding] 405532003222 CAAX protease self-immunity; Region: Abi; pfam02517 405532003223 Peptidase family M48; Region: Peptidase_M48; pfam01435 405532003224 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 405532003225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532003226 dimerization interface [polypeptide binding]; other site 405532003227 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532003228 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532003229 dimer interface [polypeptide binding]; other site 405532003230 putative CheW interface [polypeptide binding]; other site 405532003231 S-layer homology domain; Region: SLH; pfam00395 405532003232 S-layer homology domain; Region: SLH; pfam00395 405532003233 S-layer homology domain; Region: SLH; pfam00395 405532003234 S-layer homology domain; Region: SLH; pfam00395 405532003235 S-layer homology domain; Region: SLH; pfam00395 405532003236 S-layer homology domain; Region: SLH; pfam00395 405532003237 malate synthase A; Region: malate_syn_A; TIGR01344 405532003238 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 405532003239 active site 405532003240 isocitrate lyase; Provisional; Region: PRK15063 405532003241 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405532003242 tetramer interface [polypeptide binding]; other site 405532003243 active site 405532003244 Mg2+/Mn2+ binding site [ion binding]; other site 405532003245 Phosphotransferase enzyme family; Region: APH; pfam01636 405532003246 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405532003247 active site 405532003248 substrate binding site [chemical binding]; other site 405532003249 ATP binding site [chemical binding]; other site 405532003250 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405532003251 DNA-binding site [nucleotide binding]; DNA binding site 405532003252 RNA-binding motif; other site 405532003253 ComK protein; Region: ComK; pfam06338 405532003254 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405532003255 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405532003256 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405532003257 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405532003258 Catalytic site [active] 405532003259 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405532003260 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 405532003261 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405532003262 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 405532003263 Part of AAA domain; Region: AAA_19; pfam13245 405532003264 Family description; Region: UvrD_C_2; pfam13538 405532003265 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405532003266 hypothetical protein; Provisional; Region: PRK07758 405532003267 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405532003268 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 405532003269 Spore germination protein GerPC; Region: GerPC; pfam10737 405532003270 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 405532003271 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405532003272 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405532003273 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405532003274 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 405532003275 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 405532003276 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405532003277 inhibitor-cofactor binding pocket; inhibition site 405532003278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532003279 catalytic residue [active] 405532003280 hypothetical protein; Provisional; Region: PRK13673 405532003281 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 405532003282 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405532003283 active site 405532003284 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 405532003285 dimer interface [polypeptide binding]; other site 405532003286 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405532003287 Ligand Binding Site [chemical binding]; other site 405532003288 Molecular Tunnel; other site 405532003289 ferrochelatase; Provisional; Region: PRK12435 405532003290 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 405532003291 C-terminal domain interface [polypeptide binding]; other site 405532003292 active site 405532003293 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 405532003294 active site 405532003295 N-terminal domain interface [polypeptide binding]; other site 405532003296 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405532003297 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 405532003298 tetramer interface [polypeptide binding]; other site 405532003299 heme binding pocket [chemical binding]; other site 405532003300 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 405532003301 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 405532003302 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 405532003303 active site 405532003304 catalytic site [active] 405532003305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532003306 non-specific DNA binding site [nucleotide binding]; other site 405532003307 salt bridge; other site 405532003308 sequence-specific DNA binding site [nucleotide binding]; other site 405532003309 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405532003310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 405532003311 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 405532003312 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 405532003313 S1 domain; Region: S1_2; pfam13509 405532003314 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 405532003315 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405532003316 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532003317 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532003318 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532003319 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 405532003320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532003321 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405532003322 active site 405532003323 motif I; other site 405532003324 motif II; other site 405532003325 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405532003326 YjzC-like protein; Region: YjzC; pfam14168 405532003327 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 405532003328 Clp amino terminal domain; Region: Clp_N; pfam02861 405532003329 Clp amino terminal domain; Region: Clp_N; pfam02861 405532003330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532003331 Walker A motif; other site 405532003332 ATP binding site [chemical binding]; other site 405532003333 Walker B motif; other site 405532003334 arginine finger; other site 405532003335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532003336 Walker A motif; other site 405532003337 ATP binding site [chemical binding]; other site 405532003338 Walker B motif; other site 405532003339 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405532003340 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 405532003341 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 405532003342 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405532003343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532003344 NAD(P) binding site [chemical binding]; other site 405532003345 active site 405532003346 ComZ; Region: ComZ; pfam10815 405532003347 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 405532003348 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405532003349 dimer interface [polypeptide binding]; other site 405532003350 active site 405532003351 CoA binding pocket [chemical binding]; other site 405532003352 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 405532003353 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 405532003354 dimer interface [polypeptide binding]; other site 405532003355 active site 405532003356 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 405532003357 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 405532003358 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405532003359 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405532003360 active site 405532003361 HIGH motif; other site 405532003362 dimer interface [polypeptide binding]; other site 405532003363 KMSKS motif; other site 405532003364 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 405532003365 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532003366 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532003367 peptide binding site [polypeptide binding]; other site 405532003368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405532003369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532003370 dimer interface [polypeptide binding]; other site 405532003371 conserved gate region; other site 405532003372 putative PBP binding loops; other site 405532003373 ABC-ATPase subunit interface; other site 405532003374 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405532003375 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 405532003376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532003377 dimer interface [polypeptide binding]; other site 405532003378 conserved gate region; other site 405532003379 putative PBP binding loops; other site 405532003380 ABC-ATPase subunit interface; other site 405532003381 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405532003382 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405532003383 Walker A/P-loop; other site 405532003384 ATP binding site [chemical binding]; other site 405532003385 Q-loop/lid; other site 405532003386 ABC transporter signature motif; other site 405532003387 Walker B; other site 405532003388 D-loop; other site 405532003389 H-loop/switch region; other site 405532003390 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405532003391 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405532003392 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405532003393 Walker A/P-loop; other site 405532003394 ATP binding site [chemical binding]; other site 405532003395 Q-loop/lid; other site 405532003396 ABC transporter signature motif; other site 405532003397 Walker B; other site 405532003398 D-loop; other site 405532003399 H-loop/switch region; other site 405532003400 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405532003401 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405532003402 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 405532003403 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532003404 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532003405 peptide binding site [polypeptide binding]; other site 405532003406 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 405532003407 ArsC family; Region: ArsC; pfam03960 405532003408 putative catalytic residues [active] 405532003409 thiol/disulfide switch; other site 405532003410 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 405532003411 adaptor protein; Provisional; Region: PRK02315 405532003412 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 405532003413 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405532003414 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405532003415 putative active site [active] 405532003416 catalytic site [active] 405532003417 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405532003418 putative active site [active] 405532003419 catalytic site [active] 405532003420 Competence protein CoiA-like family; Region: CoiA; cl11541 405532003421 oligoendopeptidase F; Region: pepF; TIGR00181 405532003422 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 405532003423 active site 405532003424 Zn binding site [ion binding]; other site 405532003425 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405532003426 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 405532003427 catalytic residues [active] 405532003428 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 405532003429 apolar tunnel; other site 405532003430 heme binding site [chemical binding]; other site 405532003431 dimerization interface [polypeptide binding]; other site 405532003432 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 405532003433 putative active site [active] 405532003434 putative metal binding residues [ion binding]; other site 405532003435 signature motif; other site 405532003436 putative triphosphate binding site [ion binding]; other site 405532003437 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405532003438 synthetase active site [active] 405532003439 NTP binding site [chemical binding]; other site 405532003440 metal binding site [ion binding]; metal-binding site 405532003441 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 405532003442 ATP-NAD kinase; Region: NAD_kinase; pfam01513 405532003443 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405532003444 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405532003445 active site 405532003446 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 405532003447 trimer interface [polypeptide binding]; other site 405532003448 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 405532003449 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 405532003450 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 405532003451 active site 405532003452 metal binding site [ion binding]; metal-binding site 405532003453 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 405532003454 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405532003455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532003456 active site 405532003457 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532003458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532003459 S-adenosylmethionine binding site [chemical binding]; other site 405532003460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405532003461 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 405532003462 putative metal binding site; other site 405532003463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532003464 binding surface 405532003465 TPR motif; other site 405532003466 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532003467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532003468 S-adenosylmethionine binding site [chemical binding]; other site 405532003469 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 405532003470 catalytic residues [active] 405532003471 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 405532003472 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 405532003473 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532003474 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405532003475 active site 405532003476 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 405532003477 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 405532003478 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 405532003479 NAD binding site [chemical binding]; other site 405532003480 substrate binding site [chemical binding]; other site 405532003481 homodimer interface [polypeptide binding]; other site 405532003482 active site 405532003483 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 405532003484 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 405532003485 NADP binding site [chemical binding]; other site 405532003486 active site 405532003487 putative substrate binding site [chemical binding]; other site 405532003488 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 405532003489 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 405532003490 NAD binding site [chemical binding]; other site 405532003491 homotetramer interface [polypeptide binding]; other site 405532003492 homodimer interface [polypeptide binding]; other site 405532003493 substrate binding site [chemical binding]; other site 405532003494 active site 405532003495 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 405532003496 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 405532003497 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 405532003498 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 405532003499 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 405532003500 Part of AAA domain; Region: AAA_19; pfam13245 405532003501 Family description; Region: UvrD_C_2; pfam13538 405532003502 putative transposase OrfB; Reviewed; Region: PHA02517 405532003503 HTH-like domain; Region: HTH_21; pfam13276 405532003504 Integrase core domain; Region: rve; pfam00665 405532003505 Integrase core domain; Region: rve_2; pfam13333 405532003506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405532003507 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532003508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405532003509 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532003510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405532003511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532003512 Coenzyme A binding pocket [chemical binding]; other site 405532003513 hypothetical protein; Provisional; Region: PRK13679 405532003514 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405532003515 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405532003516 Putative esterase; Region: Esterase; pfam00756 405532003517 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405532003518 EamA-like transporter family; Region: EamA; pfam00892 405532003519 EamA-like transporter family; Region: EamA; pfam00892 405532003520 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405532003521 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405532003522 ligand binding site [chemical binding]; other site 405532003523 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405532003524 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 405532003525 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 405532003526 Pectate lyase; Region: Pectate_lyase; pfam03211 405532003527 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 405532003528 Na binding site [ion binding]; other site 405532003529 anthranilate synthase component I; Provisional; Region: PRK13570 405532003530 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405532003531 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405532003532 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 405532003533 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405532003534 glutamine binding [chemical binding]; other site 405532003535 catalytic triad [active] 405532003536 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 405532003537 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405532003538 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405532003539 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 405532003540 active site 405532003541 ribulose/triose binding site [chemical binding]; other site 405532003542 phosphate binding site [ion binding]; other site 405532003543 substrate (anthranilate) binding pocket [chemical binding]; other site 405532003544 product (indole) binding pocket [chemical binding]; other site 405532003545 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 405532003546 active site 405532003547 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 405532003548 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 405532003549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532003550 catalytic residue [active] 405532003551 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 405532003552 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 405532003553 substrate binding site [chemical binding]; other site 405532003554 active site 405532003555 catalytic residues [active] 405532003556 heterodimer interface [polypeptide binding]; other site 405532003557 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 405532003558 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 405532003559 L-lactate permease; Region: Lactate_perm; cl00701 405532003560 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 405532003561 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 405532003562 Double zinc ribbon; Region: DZR; pfam12773 405532003563 Predicted membrane protein [Function unknown]; Region: COG4640 405532003564 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 405532003565 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 405532003566 YARHG domain; Region: YARHG; pfam13308 405532003567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532003568 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 405532003569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532003570 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405532003571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532003572 Coenzyme A binding pocket [chemical binding]; other site 405532003573 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 405532003574 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405532003575 NADPH bind site [chemical binding]; other site 405532003576 putative FMN binding site [chemical binding]; other site 405532003577 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405532003578 putative FMN binding site [chemical binding]; other site 405532003579 NADPH bind site [chemical binding]; other site 405532003580 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 405532003581 YcaO-like family; Region: YcaO; pfam02624 405532003582 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 405532003583 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 405532003584 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 405532003585 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 405532003586 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405532003587 E3 interaction surface; other site 405532003588 lipoyl attachment site [posttranslational modification]; other site 405532003589 e3 binding domain; Region: E3_binding; pfam02817 405532003590 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405532003591 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 405532003592 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 405532003593 TPP-binding site [chemical binding]; other site 405532003594 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 405532003595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532003596 salt bridge; other site 405532003597 non-specific DNA binding site [nucleotide binding]; other site 405532003598 sequence-specific DNA binding site [nucleotide binding]; other site 405532003599 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 405532003600 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 405532003601 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 405532003602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532003603 S-adenosylmethionine binding site [chemical binding]; other site 405532003604 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405532003605 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532003606 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405532003607 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 405532003608 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405532003609 Catalytic site [active] 405532003610 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 405532003611 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 405532003612 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 405532003613 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532003614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532003615 non-specific DNA binding site [nucleotide binding]; other site 405532003616 salt bridge; other site 405532003617 sequence-specific DNA binding site [nucleotide binding]; other site 405532003618 Anti-repressor SinI; Region: SinI; pfam08671 405532003619 Anti-repressor SinI; Region: SinI; pfam08671 405532003620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405532003621 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405532003622 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 405532003623 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 405532003624 NAD(P) binding site [chemical binding]; other site 405532003625 catalytic residues [active] 405532003626 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405532003627 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 405532003628 Walker A/P-loop; other site 405532003629 ATP binding site [chemical binding]; other site 405532003630 Q-loop/lid; other site 405532003631 ABC transporter signature motif; other site 405532003632 Walker B; other site 405532003633 D-loop; other site 405532003634 H-loop/switch region; other site 405532003635 TOBE domain; Region: TOBE_2; pfam08402 405532003636 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405532003637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532003638 dimer interface [polypeptide binding]; other site 405532003639 conserved gate region; other site 405532003640 putative PBP binding loops; other site 405532003641 ABC-ATPase subunit interface; other site 405532003642 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405532003643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532003644 dimer interface [polypeptide binding]; other site 405532003645 conserved gate region; other site 405532003646 putative PBP binding loops; other site 405532003647 ABC-ATPase subunit interface; other site 405532003648 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 405532003649 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 405532003650 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405532003651 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405532003652 active site 405532003653 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 405532003654 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 405532003655 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405532003656 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405532003657 active site 405532003658 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405532003659 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 405532003660 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 405532003661 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405532003662 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405532003663 Cysteine-rich domain; Region: CCG; pfam02754 405532003664 Cysteine-rich domain; Region: CCG; pfam02754 405532003665 FAD binding domain; Region: FAD_binding_4; pfam01565 405532003666 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 405532003667 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 405532003668 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 405532003669 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 405532003670 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 405532003671 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405532003672 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405532003673 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532003674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532003675 active site 405532003676 phosphorylation site [posttranslational modification] 405532003677 intermolecular recognition site; other site 405532003678 dimerization interface [polypeptide binding]; other site 405532003679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532003680 DNA binding site [nucleotide binding] 405532003681 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405532003682 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532003683 dimerization interface [polypeptide binding]; other site 405532003684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532003685 dimer interface [polypeptide binding]; other site 405532003686 phosphorylation site [posttranslational modification] 405532003687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532003688 ATP binding site [chemical binding]; other site 405532003689 Mg2+ binding site [ion binding]; other site 405532003690 G-X-G motif; other site 405532003691 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405532003692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532003693 DNA-binding site [nucleotide binding]; DNA binding site 405532003694 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405532003695 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 405532003696 Cysteine-rich domain; Region: CCG; pfam02754 405532003697 Cysteine-rich domain; Region: CCG; pfam02754 405532003698 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 405532003699 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 405532003700 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 405532003701 Uncharacterized conserved protein [Function unknown]; Region: COG1556 405532003702 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 405532003703 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 405532003704 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 405532003705 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405532003706 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 405532003707 yybP-ykoY leader 405532003708 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405532003709 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405532003710 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405532003711 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 405532003712 dimer interaction site [polypeptide binding]; other site 405532003713 substrate-binding tunnel; other site 405532003714 active site 405532003715 catalytic site [active] 405532003716 substrate binding site [chemical binding]; other site 405532003717 polyhydroxyalkanoic acid inclusion protein PhaP; Region: phaP_Bmeg; TIGR02131 405532003718 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 405532003719 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532003720 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 405532003721 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 405532003722 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405532003723 NAD(P) binding site [chemical binding]; other site 405532003724 homotetramer interface [polypeptide binding]; other site 405532003725 homodimer interface [polypeptide binding]; other site 405532003726 active site 405532003727 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 405532003728 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 405532003729 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 405532003730 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405532003731 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405532003732 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405532003733 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405532003734 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 405532003735 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405532003736 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 405532003737 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 405532003738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532003739 dimer interface [polypeptide binding]; other site 405532003740 conserved gate region; other site 405532003741 putative PBP binding loops; other site 405532003742 ABC-ATPase subunit interface; other site 405532003743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532003744 dimer interface [polypeptide binding]; other site 405532003745 conserved gate region; other site 405532003746 putative PBP binding loops; other site 405532003747 ABC-ATPase subunit interface; other site 405532003748 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 405532003749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532003750 motif II; other site 405532003751 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 405532003752 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532003753 catalytic residue [active] 405532003754 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 405532003755 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405532003756 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405532003757 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405532003758 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405532003759 heme-binding site [chemical binding]; other site 405532003760 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 405532003761 Substrate binding site [chemical binding]; other site 405532003762 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532003763 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532003764 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532003765 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532003766 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532003767 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532003768 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532003769 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405532003770 LRR adjacent; Region: LRR_adjacent; pfam08191 405532003771 S-layer homology domain; Region: SLH; pfam00395 405532003772 S-layer homology domain; Region: SLH; pfam00395 405532003773 S-layer homology domain; Region: SLH; pfam00395 405532003774 hypothetical protein; Validated; Region: PRK06755 405532003775 intersubunit interface [polypeptide binding]; other site 405532003776 active site 405532003777 Zn2+ binding site [ion binding]; other site 405532003778 FOG: CBS domain [General function prediction only]; Region: COG0517 405532003779 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405532003780 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 405532003781 NodB motif; other site 405532003782 putative active site [active] 405532003783 putative catalytic site [active] 405532003784 Zn binding site [ion binding]; other site 405532003785 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405532003786 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 405532003787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532003788 dimer interface [polypeptide binding]; other site 405532003789 phosphorylation site [posttranslational modification] 405532003790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532003791 ATP binding site [chemical binding]; other site 405532003792 Mg2+ binding site [ion binding]; other site 405532003793 G-X-G motif; other site 405532003794 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532003795 MarR family; Region: MarR; pfam01047 405532003796 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405532003797 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405532003798 active site 405532003799 Zn binding site [ion binding]; other site 405532003800 DinB superfamily; Region: DinB_2; pfam12867 405532003801 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405532003802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532003803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532003804 dimer interface [polypeptide binding]; other site 405532003805 phosphorylation site [posttranslational modification] 405532003806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532003807 ATP binding site [chemical binding]; other site 405532003808 Mg2+ binding site [ion binding]; other site 405532003809 G-X-G motif; other site 405532003810 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 405532003811 Ligand Binding Site [chemical binding]; other site 405532003812 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 405532003813 active site 405532003814 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 405532003815 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 405532003816 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 405532003817 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 405532003818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532003819 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532003820 Coenzyme A binding pocket [chemical binding]; other site 405532003821 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 405532003822 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 405532003823 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 405532003824 Class I ribonucleotide reductase; Region: RNR_I; cd01679 405532003825 active site 405532003826 dimer interface [polypeptide binding]; other site 405532003827 catalytic residues [active] 405532003828 effector binding site; other site 405532003829 R2 peptide binding site; other site 405532003830 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 405532003831 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 405532003832 dimer interface [polypeptide binding]; other site 405532003833 putative radical transfer pathway; other site 405532003834 diiron center [ion binding]; other site 405532003835 tyrosyl radical; other site 405532003836 Predicted transcriptional regulators [Transcription]; Region: COG1725 405532003837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532003838 DNA-binding site [nucleotide binding]; DNA binding site 405532003839 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405532003840 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532003841 Walker A/P-loop; other site 405532003842 ATP binding site [chemical binding]; other site 405532003843 Q-loop/lid; other site 405532003844 ABC transporter signature motif; other site 405532003845 Walker B; other site 405532003846 D-loop; other site 405532003847 H-loop/switch region; other site 405532003848 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532003849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532003850 Walker A/P-loop; other site 405532003851 ATP binding site [chemical binding]; other site 405532003852 Q-loop/lid; other site 405532003853 ABC transporter signature motif; other site 405532003854 Walker B; other site 405532003855 D-loop; other site 405532003856 H-loop/switch region; other site 405532003857 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405532003858 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405532003859 CAAX protease self-immunity; Region: Abi; pfam02517 405532003860 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405532003861 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 405532003862 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405532003863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532003864 putative DNA binding site [nucleotide binding]; other site 405532003865 putative Zn2+ binding site [ion binding]; other site 405532003866 AsnC family; Region: AsnC_trans_reg; pfam01037 405532003867 Uncharacterized conserved protein [Function unknown]; Region: COG2128 405532003868 Isochorismatase family; Region: Isochorismatase; pfam00857 405532003869 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405532003870 catalytic triad [active] 405532003871 conserved cis-peptide bond; other site 405532003872 SseB protein; Region: SseB; cl06279 405532003873 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 405532003874 dimer interface [polypeptide binding]; other site 405532003875 catalytic triad [active] 405532003876 Nitronate monooxygenase; Region: NMO; pfam03060 405532003877 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 405532003878 FMN binding site [chemical binding]; other site 405532003879 substrate binding site [chemical binding]; other site 405532003880 putative catalytic residue [active] 405532003881 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 405532003882 DltD N-terminal region; Region: DltD_N; pfam04915 405532003883 DltD central region; Region: DltD_M; pfam04918 405532003884 DltD C-terminal region; Region: DltD_C; pfam04914 405532003885 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 405532003886 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 405532003887 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 405532003888 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 405532003889 acyl-activating enzyme (AAE) consensus motif; other site 405532003890 AMP binding site [chemical binding]; other site 405532003891 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 405532003892 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405532003893 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 405532003894 metal binding site [ion binding]; metal-binding site 405532003895 dimer interface [polypeptide binding]; other site 405532003896 flavodoxin; Provisional; Region: PRK06756 405532003897 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 405532003898 Phosphotransferase enzyme family; Region: APH; pfam01636 405532003899 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405532003900 active site 405532003901 substrate binding site [chemical binding]; other site 405532003902 ATP binding site [chemical binding]; other site 405532003903 multidrug efflux protein; Reviewed; Region: PRK01766 405532003904 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 405532003905 cation binding site [ion binding]; other site 405532003906 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405532003907 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405532003908 catalytic residues [active] 405532003909 Regulatory protein YrvL; Region: YrvL; pfam14184 405532003910 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532003911 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 405532003912 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405532003913 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 405532003914 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405532003915 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405532003916 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405532003917 hypothetical protein; Provisional; Region: PRK03094 405532003918 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 405532003919 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405532003920 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405532003921 homodimer interface [polypeptide binding]; other site 405532003922 substrate-cofactor binding pocket; other site 405532003923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532003924 catalytic residue [active] 405532003925 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 405532003926 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405532003927 PYR/PP interface [polypeptide binding]; other site 405532003928 dimer interface [polypeptide binding]; other site 405532003929 TPP binding site [chemical binding]; other site 405532003930 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405532003931 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405532003932 TPP-binding site [chemical binding]; other site 405532003933 dimer interface [polypeptide binding]; other site 405532003934 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 405532003935 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 405532003936 putative valine binding site [chemical binding]; other site 405532003937 dimer interface [polypeptide binding]; other site 405532003938 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 405532003939 ketol-acid reductoisomerase; Provisional; Region: PRK05479 405532003940 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 405532003941 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405532003942 2-isopropylmalate synthase; Validated; Region: PRK00915 405532003943 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 405532003944 active site 405532003945 catalytic residues [active] 405532003946 metal binding site [ion binding]; metal-binding site 405532003947 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 405532003948 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 405532003949 tartrate dehydrogenase; Region: TTC; TIGR02089 405532003950 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 405532003951 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 405532003952 substrate binding site [chemical binding]; other site 405532003953 ligand binding site [chemical binding]; other site 405532003954 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 405532003955 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 405532003956 substrate binding site [chemical binding]; other site 405532003957 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 405532003958 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405532003959 dimer interface [polypeptide binding]; other site 405532003960 motif 1; other site 405532003961 active site 405532003962 motif 2; other site 405532003963 motif 3; other site 405532003964 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 405532003965 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 405532003966 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 405532003967 histidinol dehydrogenase; Region: hisD; TIGR00069 405532003968 NAD binding site [chemical binding]; other site 405532003969 dimerization interface [polypeptide binding]; other site 405532003970 product binding site; other site 405532003971 substrate binding site [chemical binding]; other site 405532003972 zinc binding site [ion binding]; other site 405532003973 catalytic residues [active] 405532003974 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 405532003975 putative active site pocket [active] 405532003976 4-fold oligomerization interface [polypeptide binding]; other site 405532003977 metal binding residues [ion binding]; metal-binding site 405532003978 3-fold/trimer interface [polypeptide binding]; other site 405532003979 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 405532003980 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 405532003981 putative active site [active] 405532003982 oxyanion strand; other site 405532003983 catalytic triad [active] 405532003984 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 405532003985 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 405532003986 catalytic residues [active] 405532003987 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 405532003988 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 405532003989 substrate binding site [chemical binding]; other site 405532003990 glutamase interaction surface [polypeptide binding]; other site 405532003991 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 405532003992 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 405532003993 metal binding site [ion binding]; metal-binding site 405532003994 histidinol-phosphatase; Validated; Region: PRK06740 405532003995 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 405532003996 dimer interface [polypeptide binding]; other site 405532003997 active site 405532003998 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 405532003999 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 405532004000 putative ligand binding site [chemical binding]; other site 405532004001 putative NAD binding site [chemical binding]; other site 405532004002 catalytic site [active] 405532004003 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 405532004004 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 405532004005 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405532004006 Sulfatase; Region: Sulfatase; pfam00884 405532004007 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405532004008 Lysine riboswitch 405532004009 diaminopimelate decarboxylase; Region: lysA; TIGR01048 405532004010 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 405532004011 active site 405532004012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405532004013 substrate binding site [chemical binding]; other site 405532004014 catalytic residues [active] 405532004015 dimer interface [polypeptide binding]; other site 405532004016 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 405532004017 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 405532004018 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405532004019 Active Sites [active] 405532004020 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 405532004021 ATP-sulfurylase; Region: ATPS; cd00517 405532004022 active site 405532004023 HXXH motif; other site 405532004024 flexible loop; other site 405532004025 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 405532004026 AAA domain; Region: AAA_18; pfam13238 405532004027 ligand-binding site [chemical binding]; other site 405532004028 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 405532004029 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405532004030 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405532004031 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 405532004032 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 405532004033 active site 405532004034 SAM binding site [chemical binding]; other site 405532004035 homodimer interface [polypeptide binding]; other site 405532004036 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 405532004037 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 405532004038 putative active site [active] 405532004039 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 405532004040 putative active site [active] 405532004041 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 405532004042 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 405532004043 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405532004044 Na2 binding site [ion binding]; other site 405532004045 putative substrate binding site 1 [chemical binding]; other site 405532004046 Na binding site 1 [ion binding]; other site 405532004047 putative substrate binding site 2 [chemical binding]; other site 405532004048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405532004049 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405532004050 Peptidase family M23; Region: Peptidase_M23; pfam01551 405532004051 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405532004052 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 405532004053 Protein of unknown function (DUF402); Region: DUF402; cl00979 405532004054 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 405532004055 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 405532004056 Vpu protein; Region: Vpu; pfam00558 405532004057 PspA/IM30 family; Region: PspA_IM30; pfam04012 405532004058 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 405532004059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405532004060 Histidine kinase; Region: HisKA_3; pfam07730 405532004061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532004062 ATP binding site [chemical binding]; other site 405532004063 Mg2+ binding site [ion binding]; other site 405532004064 G-X-G motif; other site 405532004065 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405532004066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532004067 active site 405532004068 phosphorylation site [posttranslational modification] 405532004069 intermolecular recognition site; other site 405532004070 dimerization interface [polypeptide binding]; other site 405532004071 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405532004072 DNA binding residues [nucleotide binding] 405532004073 dimerization interface [polypeptide binding]; other site 405532004074 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405532004075 E3 interaction surface; other site 405532004076 lipoyl attachment site [posttranslational modification]; other site 405532004077 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405532004078 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405532004079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532004080 S-adenosylmethionine binding site [chemical binding]; other site 405532004081 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 405532004082 Peptidase family M50; Region: Peptidase_M50; pfam02163 405532004083 active site 405532004084 putative substrate binding region [chemical binding]; other site 405532004085 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 405532004086 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 405532004087 heme-binding site [chemical binding]; other site 405532004088 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 405532004089 FAD binding pocket [chemical binding]; other site 405532004090 FAD binding motif [chemical binding]; other site 405532004091 phosphate binding motif [ion binding]; other site 405532004092 beta-alpha-beta structure motif; other site 405532004093 NAD binding pocket [chemical binding]; other site 405532004094 Heme binding pocket [chemical binding]; other site 405532004095 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405532004096 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405532004097 ligand binding site [chemical binding]; other site 405532004098 flexible hinge region; other site 405532004099 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405532004100 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405532004101 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 405532004102 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 405532004103 Transglycosylase; Region: Transgly; pfam00912 405532004104 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405532004105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532004106 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 405532004107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 405532004108 putative active site [active] 405532004109 heme pocket [chemical binding]; other site 405532004110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532004111 dimer interface [polypeptide binding]; other site 405532004112 phosphorylation site [posttranslational modification] 405532004113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532004114 ATP binding site [chemical binding]; other site 405532004115 Mg2+ binding site [ion binding]; other site 405532004116 G-X-G motif; other site 405532004117 Protein of unknown function DUF72; Region: DUF72; pfam01904 405532004118 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 405532004119 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405532004120 active site 405532004121 DNA binding site [nucleotide binding] 405532004122 Int/Topo IB signature motif; other site 405532004123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532004124 dimerization interface [polypeptide binding]; other site 405532004125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532004126 dimer interface [polypeptide binding]; other site 405532004127 phosphorylation site [posttranslational modification] 405532004128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532004129 ATP binding site [chemical binding]; other site 405532004130 Mg2+ binding site [ion binding]; other site 405532004131 G-X-G motif; other site 405532004132 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 405532004133 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 405532004134 Predicted integral membrane protein [Function unknown]; Region: COG0392 405532004135 Uncharacterized conserved protein [Function unknown]; Region: COG2898 405532004136 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 405532004137 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 405532004138 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405532004139 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405532004140 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405532004141 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532004142 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405532004143 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 405532004144 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 405532004145 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405532004146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532004147 RNA binding surface [nucleotide binding]; other site 405532004148 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 405532004149 active site 405532004150 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405532004151 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405532004152 catalytic residues [active] 405532004153 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 405532004154 ResB-like family; Region: ResB; pfam05140 405532004155 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 405532004156 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 405532004157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532004158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532004159 active site 405532004160 phosphorylation site [posttranslational modification] 405532004161 intermolecular recognition site; other site 405532004162 dimerization interface [polypeptide binding]; other site 405532004163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532004164 DNA binding site [nucleotide binding] 405532004165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 405532004166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532004167 dimerization interface [polypeptide binding]; other site 405532004168 PAS domain; Region: PAS; smart00091 405532004169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532004170 dimer interface [polypeptide binding]; other site 405532004171 phosphorylation site [posttranslational modification] 405532004172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532004173 ATP binding site [chemical binding]; other site 405532004174 Mg2+ binding site [ion binding]; other site 405532004175 G-X-G motif; other site 405532004176 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 405532004177 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405532004178 Peptidase family M23; Region: Peptidase_M23; pfam01551 405532004179 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 405532004180 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405532004181 Predicted membrane protein [Function unknown]; Region: COG3601 405532004182 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 405532004183 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 405532004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 405532004185 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405532004186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532004187 ATP binding site [chemical binding]; other site 405532004188 putative Mg++ binding site [ion binding]; other site 405532004189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532004190 nucleotide binding region [chemical binding]; other site 405532004191 ATP-binding site [chemical binding]; other site 405532004192 CAAX protease self-immunity; Region: Abi; pfam02517 405532004193 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405532004194 phosphodiesterase YaeI; Provisional; Region: PRK11340 405532004195 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405532004196 putative active site [active] 405532004197 putative metal binding site [ion binding]; other site 405532004198 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405532004199 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 405532004200 DNA binding residues [nucleotide binding] 405532004201 B12 binding domain; Region: B12-binding_2; pfam02607 405532004202 adaptor protein; Provisional; Region: PRK02899 405532004203 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 405532004204 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 405532004205 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 405532004206 NAD(P) binding site [chemical binding]; other site 405532004207 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 405532004208 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405532004209 amidase catalytic site [active] 405532004210 Zn binding residues [ion binding]; other site 405532004211 substrate binding site [chemical binding]; other site 405532004212 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 405532004213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 405532004214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532004215 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 405532004216 active site 405532004217 homodimer interface [polypeptide binding]; other site 405532004218 homotetramer interface [polypeptide binding]; other site 405532004219 cytidylate kinase; Provisional; Region: cmk; PRK00023 405532004220 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 405532004221 CMP-binding site; other site 405532004222 The sites determining sugar specificity; other site 405532004223 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 405532004224 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 405532004225 RNA binding site [nucleotide binding]; other site 405532004226 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 405532004227 RNA binding site [nucleotide binding]; other site 405532004228 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 405532004229 RNA binding site [nucleotide binding]; other site 405532004230 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 405532004231 RNA binding site [nucleotide binding]; other site 405532004232 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 405532004233 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 405532004234 homotetramer interface [polypeptide binding]; other site 405532004235 FMN binding site [chemical binding]; other site 405532004236 homodimer contacts [polypeptide binding]; other site 405532004237 putative active site [active] 405532004238 putative substrate binding site [chemical binding]; other site 405532004239 YpzI-like protein; Region: YpzI; pfam14140 405532004240 YIEGIA protein; Region: YIEGIA; pfam14045 405532004241 GTP-binding protein Der; Reviewed; Region: PRK00093 405532004242 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 405532004243 G1 box; other site 405532004244 GTP/Mg2+ binding site [chemical binding]; other site 405532004245 Switch I region; other site 405532004246 G2 box; other site 405532004247 Switch II region; other site 405532004248 G3 box; other site 405532004249 G4 box; other site 405532004250 G5 box; other site 405532004251 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 405532004252 G1 box; other site 405532004253 GTP/Mg2+ binding site [chemical binding]; other site 405532004254 Switch I region; other site 405532004255 G2 box; other site 405532004256 G3 box; other site 405532004257 Switch II region; other site 405532004258 G4 box; other site 405532004259 G5 box; other site 405532004260 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 405532004261 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405532004262 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 405532004263 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 405532004264 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 405532004265 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 405532004266 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 405532004267 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405532004268 IHF dimer interface [polypeptide binding]; other site 405532004269 IHF - DNA interface [nucleotide binding]; other site 405532004270 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 405532004271 homodecamer interface [polypeptide binding]; other site 405532004272 GTP cyclohydrolase I; Provisional; Region: PLN03044 405532004273 active site 405532004274 putative catalytic site residues [active] 405532004275 zinc binding site [ion binding]; other site 405532004276 GTP-CH-I/GFRP interaction surface; other site 405532004277 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 405532004278 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 405532004279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532004280 S-adenosylmethionine binding site [chemical binding]; other site 405532004281 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405532004282 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405532004283 substrate binding pocket [chemical binding]; other site 405532004284 chain length determination region; other site 405532004285 substrate-Mg2+ binding site; other site 405532004286 catalytic residues [active] 405532004287 aspartate-rich region 1; other site 405532004288 active site lid residues [active] 405532004289 aspartate-rich region 2; other site 405532004290 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 405532004291 active site 405532004292 multimer interface [polypeptide binding]; other site 405532004293 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 405532004294 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 405532004295 Tetramer interface [polypeptide binding]; other site 405532004296 active site 405532004297 FMN-binding site [chemical binding]; other site 405532004298 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 405532004299 active site 405532004300 dimer interface [polypeptide binding]; other site 405532004301 metal binding site [ion binding]; metal-binding site 405532004302 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 405532004303 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532004304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532004305 homodimer interface [polypeptide binding]; other site 405532004306 catalytic residue [active] 405532004307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532004308 binding surface 405532004309 TPR motif; other site 405532004310 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 405532004311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532004312 binding surface 405532004313 TPR motif; other site 405532004314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532004315 binding surface 405532004316 TPR motif; other site 405532004317 hypothetical protein; Provisional; Region: PRK03636 405532004318 UPF0302 domain; Region: UPF0302; pfam08864 405532004319 IDEAL domain; Region: IDEAL; pfam08858 405532004320 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 405532004321 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 405532004322 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 405532004323 iron-sulfur cluster [ion binding]; other site 405532004324 [2Fe-2S] cluster binding site [ion binding]; other site 405532004325 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 405532004326 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 405532004327 interchain domain interface [polypeptide binding]; other site 405532004328 intrachain domain interface; other site 405532004329 heme bH binding site [chemical binding]; other site 405532004330 Qi binding site; other site 405532004331 heme bL binding site [chemical binding]; other site 405532004332 Qo binding site; other site 405532004333 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 405532004334 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 405532004335 interchain domain interface [polypeptide binding]; other site 405532004336 intrachain domain interface; other site 405532004337 Qi binding site; other site 405532004338 Qo binding site; other site 405532004339 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405532004340 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405532004341 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 405532004342 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 405532004343 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 405532004344 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 405532004345 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 405532004346 active site 405532004347 Fe-S cluster binding site [ion binding]; other site 405532004348 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532004349 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532004350 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532004351 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532004352 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 405532004353 homodimer interface [polypeptide binding]; other site 405532004354 metal binding site [ion binding]; metal-binding site 405532004355 dihydrodipicolinate reductase; Provisional; Region: PRK00048 405532004356 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 405532004357 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 405532004358 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 405532004359 active site 405532004360 dimer interfaces [polypeptide binding]; other site 405532004361 catalytic residues [active] 405532004362 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 405532004363 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 405532004364 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 405532004365 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 405532004366 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 405532004367 active site 405532004368 NTP binding site [chemical binding]; other site 405532004369 metal binding triad [ion binding]; metal-binding site 405532004370 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 405532004371 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 405532004372 Biotin operon repressor [Transcription]; Region: BirA; COG1654 405532004373 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 405532004374 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 405532004375 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 405532004376 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 405532004377 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 405532004378 oligomerization interface [polypeptide binding]; other site 405532004379 active site 405532004380 metal binding site [ion binding]; metal-binding site 405532004381 pantoate--beta-alanine ligase; Region: panC; TIGR00018 405532004382 Pantoate-beta-alanine ligase; Region: PanC; cd00560 405532004383 active site 405532004384 ATP-binding site [chemical binding]; other site 405532004385 pantoate-binding site; other site 405532004386 HXXH motif; other site 405532004387 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 405532004388 tetramerization interface [polypeptide binding]; other site 405532004389 active site 405532004390 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 405532004391 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405532004392 active site 405532004393 catalytic site [active] 405532004394 substrate binding site [chemical binding]; other site 405532004395 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 405532004396 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405532004397 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 405532004398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 405532004399 aspartate aminotransferase; Provisional; Region: PRK05764 405532004400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532004401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532004402 homodimer interface [polypeptide binding]; other site 405532004403 catalytic residue [active] 405532004404 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 405532004405 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 405532004406 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405532004407 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 405532004408 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405532004409 minor groove reading motif; other site 405532004410 helix-hairpin-helix signature motif; other site 405532004411 substrate binding pocket [chemical binding]; other site 405532004412 active site 405532004413 Transglycosylase; Region: Transgly; pfam00912 405532004414 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405532004415 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532004416 Fibronectin type III domain; Region: fn3; pfam00041 405532004417 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 405532004418 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 405532004419 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 405532004420 YppF-like protein; Region: YppF; pfam14178 405532004421 YppG-like protein; Region: YppG; pfam14179 405532004422 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 405532004423 hypothetical protein; Provisional; Region: PRK13660 405532004424 cell division protein GpsB; Provisional; Region: PRK14127 405532004425 DivIVA domain; Region: DivI1A_domain; TIGR03544 405532004426 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 405532004427 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 405532004428 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 405532004429 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 405532004430 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 405532004431 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 405532004432 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405532004433 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 405532004434 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 405532004435 active site 405532004436 Zn binding site [ion binding]; other site 405532004437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532004438 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532004439 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405532004440 active site 405532004441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532004442 active site 405532004443 xanthine permease; Region: pbuX; TIGR03173 405532004444 Predicted membrane protein [Function unknown]; Region: COG2311 405532004445 Protein of unknown function (DUF418); Region: DUF418; cl12135 405532004446 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405532004447 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 405532004448 Dynamin family; Region: Dynamin_N; pfam00350 405532004449 G1 box; other site 405532004450 GTP/Mg2+ binding site [chemical binding]; other site 405532004451 G2 box; other site 405532004452 Switch I region; other site 405532004453 G3 box; other site 405532004454 Switch II region; other site 405532004455 G4 box; other site 405532004456 G5 box; other site 405532004457 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405532004458 Dynamin family; Region: Dynamin_N; pfam00350 405532004459 G1 box; other site 405532004460 GTP/Mg2+ binding site [chemical binding]; other site 405532004461 G2 box; other site 405532004462 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 405532004463 G3 box; other site 405532004464 Switch II region; other site 405532004465 GTP/Mg2+ binding site [chemical binding]; other site 405532004466 G4 box; other site 405532004467 G5 box; other site 405532004468 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 405532004469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532004470 Coenzyme A binding pocket [chemical binding]; other site 405532004471 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 405532004472 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 405532004473 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 405532004474 active site residue [active] 405532004475 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 405532004476 active site residue [active] 405532004477 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 405532004478 Predicted membrane protein [Function unknown]; Region: COG3766 405532004479 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 405532004480 ykoK leader 405532004481 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 405532004482 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405532004483 5'-3' exonuclease; Region: 53EXOc; smart00475 405532004484 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405532004485 active site 405532004486 metal binding site 1 [ion binding]; metal-binding site 405532004487 putative 5' ssDNA interaction site; other site 405532004488 metal binding site 3; metal-binding site 405532004489 metal binding site 2 [ion binding]; metal-binding site 405532004490 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405532004491 putative DNA binding site [nucleotide binding]; other site 405532004492 putative metal binding site [ion binding]; other site 405532004493 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 405532004494 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 405532004495 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 405532004496 Chain length determinant protein; Region: Wzz; cl15801 405532004497 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405532004498 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405532004499 Bacterial sugar transferase; Region: Bac_transf; pfam02397 405532004500 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405532004501 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405532004502 O-Antigen ligase; Region: Wzy_C; pfam04932 405532004503 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405532004504 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405532004505 active site 405532004506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405532004507 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405532004508 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 405532004509 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004510 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004511 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004512 Domain of unknown function DUF11; Region: DUF11; cl17728 405532004513 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004514 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004515 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004516 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004517 Domain of unknown function DUF11; Region: DUF11; cl17728 405532004518 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004519 Domain of unknown function DUF11; Region: DUF11; cl17728 405532004520 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004521 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004522 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004523 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004524 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004525 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004526 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004527 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004528 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004529 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004530 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004531 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004532 Domain of unknown function DUF11; Region: DUF11; cl17728 405532004533 Domain of unknown function DUF11; Region: DUF11; cl17728 405532004534 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004535 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004536 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532004537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532004538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532004539 Coenzyme A binding pocket [chemical binding]; other site 405532004540 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405532004541 Isochorismatase family; Region: Isochorismatase; pfam00857 405532004542 catalytic triad [active] 405532004543 conserved cis-peptide bond; other site 405532004544 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532004545 EamA-like transporter family; Region: EamA; pfam00892 405532004546 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 405532004547 RNA/DNA hybrid binding site [nucleotide binding]; other site 405532004548 active site 405532004549 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 405532004550 active site 405532004551 catalytic residues [active] 405532004552 QueT transporter; Region: QueT; pfam06177 405532004553 hypothetical protein; Validated; Region: PRK07708 405532004554 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 405532004555 RNA/DNA hybrid binding site [nucleotide binding]; other site 405532004556 active site 405532004557 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 405532004558 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 405532004559 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405532004560 DNA-binding site [nucleotide binding]; DNA binding site 405532004561 RNA-binding motif; other site 405532004562 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 405532004563 LysE type translocator; Region: LysE; pfam01810 405532004564 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 405532004565 Protein of unknown function, DUF485; Region: DUF485; pfam04341 405532004566 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405532004567 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 405532004568 Na binding site [ion binding]; other site 405532004569 aminotransferase; Validated; Region: PRK07678 405532004570 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405532004571 inhibitor-cofactor binding pocket; inhibition site 405532004572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532004573 catalytic residue [active] 405532004574 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405532004575 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405532004576 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405532004577 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405532004578 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532004579 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405532004580 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405532004581 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405532004582 DNA binding residues [nucleotide binding] 405532004583 drug binding residues [chemical binding]; other site 405532004584 dimer interface [polypeptide binding]; other site 405532004585 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 405532004586 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 405532004587 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 405532004588 Predicted membrane protein [Function unknown]; Region: COG2323 405532004589 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405532004590 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405532004591 putative active site [active] 405532004592 Tic20-like protein; Region: Tic20; pfam09685 405532004593 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 405532004594 dimer interface [polypeptide binding]; other site 405532004595 FMN binding site [chemical binding]; other site 405532004596 NADPH bind site [chemical binding]; other site 405532004597 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405532004598 conserved cys residue [active] 405532004599 RNA polymerase factor sigma-70; Validated; Region: PRK06811 405532004600 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532004601 DNA binding residues [nucleotide binding] 405532004602 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405532004603 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405532004604 bacterial Hfq-like; Region: Hfq; cd01716 405532004605 hexamer interface [polypeptide binding]; other site 405532004606 Sm1 motif; other site 405532004607 RNA binding site [nucleotide binding]; other site 405532004608 Sm2 motif; other site 405532004609 HD domain; Region: HD_3; pfam13023 405532004610 flagellar motor protein MotP; Reviewed; Region: PRK06743 405532004611 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 405532004612 flagellar motor protein MotS; Reviewed; Region: PRK06742 405532004613 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405532004614 ligand binding site [chemical binding]; other site 405532004615 Response regulator receiver domain; Region: Response_reg; pfam00072 405532004616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532004617 active site 405532004618 phosphorylation site [posttranslational modification] 405532004619 intermolecular recognition site; other site 405532004620 dimerization interface [polypeptide binding]; other site 405532004621 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 405532004622 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405532004623 putative binding surface; other site 405532004624 active site 405532004625 P2 response regulator binding domain; Region: P2; pfam07194 405532004626 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 405532004627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532004628 ATP binding site [chemical binding]; other site 405532004629 Mg2+ binding site [ion binding]; other site 405532004630 G-X-G motif; other site 405532004631 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 405532004632 flagellar motor switch protein; Reviewed; Region: PRK06782 405532004633 CheC-like family; Region: CheC; pfam04509 405532004634 CheC-like family; Region: CheC; pfam04509 405532004635 CheC-like family; Region: CheC; pfam04509 405532004636 CheC-like family; Region: CheC; pfam04509 405532004637 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 405532004638 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 405532004639 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 405532004640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532004641 Protein of unknown function (DUF327); Region: DUF327; pfam03885 405532004642 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 405532004643 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 405532004644 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405532004645 flagellar capping protein; Validated; Region: fliD; PRK06798 405532004646 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 405532004647 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 405532004648 Flagellar protein FliS; Region: FliS; cl00654 405532004649 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 405532004650 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 405532004651 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 405532004652 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405532004653 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 405532004654 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 405532004655 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 405532004656 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 405532004657 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 405532004658 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 405532004659 FliG C-terminal domain; Region: FliG_C; pfam01706 405532004660 flagellar assembly protein H; Validated; Region: fliH; PRK06800 405532004661 Flagellar assembly protein FliH; Region: FliH; pfam02108 405532004662 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 405532004663 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405532004664 Walker A motif; other site 405532004665 ATP binding site [chemical binding]; other site 405532004666 Walker B motif; other site 405532004667 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 405532004668 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 405532004669 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 405532004670 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 405532004671 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405532004672 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 405532004673 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405532004674 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 405532004675 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 405532004676 Response regulator receiver domain; Region: Response_reg; pfam00072 405532004677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532004678 active site 405532004679 phosphorylation site [posttranslational modification] 405532004680 intermolecular recognition site; other site 405532004681 dimerization interface [polypeptide binding]; other site 405532004682 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 405532004683 flagellin; Provisional; Region: PRK12807 405532004684 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405532004685 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 405532004686 flagellin; Reviewed; Region: PRK08869 405532004687 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405532004688 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 405532004689 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 405532004690 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405532004691 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405532004692 catalytic residue [active] 405532004693 flagellar motor switch protein; Validated; Region: PRK06789 405532004694 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 405532004695 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 405532004696 flagellar motor switch protein; Validated; Region: PRK06788 405532004697 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 405532004698 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 405532004699 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 405532004700 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 405532004701 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 405532004702 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 405532004703 FHIPEP family; Region: FHIPEP; pfam00771 405532004704 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 405532004705 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405532004706 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 405532004707 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 405532004708 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 405532004709 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 405532004710 Predicted transcriptional regulators [Transcription]; Region: COG1378 405532004711 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405532004712 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405532004713 C-terminal domain interface [polypeptide binding]; other site 405532004714 sugar binding site [chemical binding]; other site 405532004715 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 405532004716 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 405532004717 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 405532004718 Dienelactone hydrolase family; Region: DLH; pfam01738 405532004719 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405532004720 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 405532004721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532004722 non-specific DNA binding site [nucleotide binding]; other site 405532004723 salt bridge; other site 405532004724 sequence-specific DNA binding site [nucleotide binding]; other site 405532004725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532004726 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532004727 putative substrate translocation pore; other site 405532004728 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 405532004729 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 405532004730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532004731 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532004732 dimerization interface [polypeptide binding]; other site 405532004733 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405532004734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532004735 Walker A/P-loop; other site 405532004736 ATP binding site [chemical binding]; other site 405532004737 Q-loop/lid; other site 405532004738 ABC transporter signature motif; other site 405532004739 Walker B; other site 405532004740 D-loop; other site 405532004741 H-loop/switch region; other site 405532004742 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 405532004743 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 405532004744 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405532004745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532004746 dimer interface [polypeptide binding]; other site 405532004747 conserved gate region; other site 405532004748 putative PBP binding loops; other site 405532004749 ABC-ATPase subunit interface; other site 405532004750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532004751 dimer interface [polypeptide binding]; other site 405532004752 conserved gate region; other site 405532004753 putative PBP binding loops; other site 405532004754 ABC-ATPase subunit interface; other site 405532004755 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 405532004756 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 405532004757 Beta-Casp domain; Region: Beta-Casp; smart01027 405532004758 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405532004759 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 405532004760 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405532004761 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405532004762 catalytic core [active] 405532004763 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 405532004764 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532004765 hypothetical protein; Provisional; Region: PRK09272 405532004766 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532004767 MarR family; Region: MarR_2; pfam12802 405532004768 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 405532004769 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405532004770 active site 405532004771 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 405532004772 dimer interface [polypeptide binding]; other site 405532004773 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405532004774 Ligand Binding Site [chemical binding]; other site 405532004775 Molecular Tunnel; other site 405532004776 RNA polymerase factor sigma-70; Validated; Region: PRK06811 405532004777 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532004778 DNA binding residues [nucleotide binding] 405532004779 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 405532004780 VPS10 domain; Region: VPS10; smart00602 405532004781 VPS10 domain; Region: VPS10; smart00602 405532004782 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 405532004783 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405532004784 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 405532004785 Transcriptional regulators [Transcription]; Region: GntR; COG1802 405532004786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532004787 DNA-binding site [nucleotide binding]; DNA binding site 405532004788 FCD domain; Region: FCD; pfam07729 405532004789 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532004790 EamA-like transporter family; Region: EamA; pfam00892 405532004791 EamA-like transporter family; Region: EamA; pfam00892 405532004792 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 405532004793 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405532004794 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 405532004795 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 405532004796 Predicted permeases [General function prediction only]; Region: COG0701 405532004797 TIGR03943 family protein; Region: TIGR03943 405532004798 Methyltransferase domain; Region: Methyltransf_24; pfam13578 405532004799 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405532004800 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405532004801 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 405532004802 DNA binding residues [nucleotide binding] 405532004803 putative dimer interface [polypeptide binding]; other site 405532004804 short chain dehydrogenase; Provisional; Region: PRK06123 405532004805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532004806 NAD(P) binding site [chemical binding]; other site 405532004807 active site 405532004808 fumarate hydratase; Reviewed; Region: fumC; PRK00485 405532004809 Class II fumarases; Region: Fumarase_classII; cd01362 405532004810 active site 405532004811 tetramer interface [polypeptide binding]; other site 405532004812 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405532004813 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 405532004814 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405532004815 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 405532004816 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 405532004817 active site pocket [active] 405532004818 oxyanion hole [active] 405532004819 catalytic triad [active] 405532004820 active site nucleophile [active] 405532004821 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 405532004822 Penicillinase repressor; Region: Pencillinase_R; pfam03965 405532004823 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 405532004824 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 405532004825 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 405532004826 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405532004827 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405532004828 catalytic residues [active] 405532004829 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 405532004830 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405532004831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532004832 non-specific DNA binding site [nucleotide binding]; other site 405532004833 salt bridge; other site 405532004834 sequence-specific DNA binding site [nucleotide binding]; other site 405532004835 Cupin domain; Region: Cupin_2; pfam07883 405532004836 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 405532004837 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 405532004838 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532004839 catalytic residue [active] 405532004840 Protein of unknown function (DUF445); Region: DUF445; pfam04286 405532004841 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 405532004842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532004843 DNA binding residues [nucleotide binding] 405532004844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405532004845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532004846 active site 405532004847 phosphorylation site [posttranslational modification] 405532004848 intermolecular recognition site; other site 405532004849 dimerization interface [polypeptide binding]; other site 405532004850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405532004851 DNA binding residues [nucleotide binding] 405532004852 dimerization interface [polypeptide binding]; other site 405532004853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405532004854 Histidine kinase; Region: HisKA_3; pfam07730 405532004855 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405532004856 Mg2+ binding site [ion binding]; other site 405532004857 G-X-G motif; other site 405532004858 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532004859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532004860 Walker A/P-loop; other site 405532004861 ATP binding site [chemical binding]; other site 405532004862 Q-loop/lid; other site 405532004863 ABC transporter signature motif; other site 405532004864 Walker B; other site 405532004865 D-loop; other site 405532004866 H-loop/switch region; other site 405532004867 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405532004868 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405532004869 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405532004870 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405532004871 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405532004872 PLD-like domain; Region: PLDc_2; pfam13091 405532004873 putative active site [active] 405532004874 catalytic site [active] 405532004875 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405532004876 PLD-like domain; Region: PLDc_2; pfam13091 405532004877 putative active site [active] 405532004878 catalytic site [active] 405532004879 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405532004880 putative nucleotide binding site [chemical binding]; other site 405532004881 uridine monophosphate binding site [chemical binding]; other site 405532004882 homohexameric interface [polypeptide binding]; other site 405532004883 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405532004884 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 405532004885 aspartate ammonia-lyase; Provisional; Region: PRK14515 405532004886 Aspartase; Region: Aspartase; cd01357 405532004887 active sites [active] 405532004888 tetramer interface [polypeptide binding]; other site 405532004889 malate dehydrogenase; Provisional; Region: PRK13529 405532004890 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405532004891 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 405532004892 NAD(P) binding site [chemical binding]; other site 405532004893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532004894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532004895 ATP binding site [chemical binding]; other site 405532004896 Mg2+ binding site [ion binding]; other site 405532004897 G-X-G motif; other site 405532004898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532004899 Response regulator receiver domain; Region: Response_reg; pfam00072 405532004900 active site 405532004901 phosphorylation site [posttranslational modification] 405532004902 intermolecular recognition site; other site 405532004903 dimerization interface [polypeptide binding]; other site 405532004904 YcbB domain; Region: YcbB; pfam08664 405532004905 SWIM zinc finger; Region: SWIM; pfam04434 405532004906 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 405532004907 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 405532004908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532004909 ATP binding site [chemical binding]; other site 405532004910 putative Mg++ binding site [ion binding]; other site 405532004911 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532004912 nucleotide binding region [chemical binding]; other site 405532004913 ATP-binding site [chemical binding]; other site 405532004914 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 405532004915 dimer interface [polypeptide binding]; other site 405532004916 active site 405532004917 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405532004918 aspartate kinase; Reviewed; Region: PRK06635 405532004919 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 405532004920 putative nucleotide binding site [chemical binding]; other site 405532004921 putative catalytic residues [active] 405532004922 putative Mg ion binding site [ion binding]; other site 405532004923 putative aspartate binding site [chemical binding]; other site 405532004924 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 405532004925 putative allosteric regulatory site; other site 405532004926 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 405532004927 putative allosteric regulatory residue; other site 405532004928 Lysine riboswitch 405532004929 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 405532004930 YndJ-like protein; Region: YndJ; pfam14158 405532004931 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405532004932 putative active site [active] 405532004933 nucleotide binding site [chemical binding]; other site 405532004934 nudix motif; other site 405532004935 putative metal binding site [ion binding]; other site 405532004936 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532004937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532004938 putative substrate translocation pore; other site 405532004939 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 405532004940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532004941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532004942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532004943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532004944 putative substrate translocation pore; other site 405532004945 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 405532004946 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405532004947 dimer interface [polypeptide binding]; other site 405532004948 active site 405532004949 CoA binding pocket [chemical binding]; other site 405532004950 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 405532004951 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 405532004952 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405532004953 HflX GTPase family; Region: HflX; cd01878 405532004954 G1 box; other site 405532004955 GTP/Mg2+ binding site [chemical binding]; other site 405532004956 Switch I region; other site 405532004957 G2 box; other site 405532004958 G3 box; other site 405532004959 Switch II region; other site 405532004960 G4 box; other site 405532004961 G5 box; other site 405532004962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532004963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532004964 putative substrate translocation pore; other site 405532004965 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405532004966 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405532004967 dimer interface [polypeptide binding]; other site 405532004968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532004969 catalytic residue [active] 405532004970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532004971 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 405532004972 metal binding triad [ion binding]; metal-binding site 405532004973 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 405532004974 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405532004975 Na2 binding site [ion binding]; other site 405532004976 putative substrate binding site 1 [chemical binding]; other site 405532004977 Na binding site 1 [ion binding]; other site 405532004978 putative substrate binding site 2 [chemical binding]; other site 405532004979 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405532004980 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 405532004981 NodB motif; other site 405532004982 putative active site [active] 405532004983 putative catalytic site [active] 405532004984 putative Zn binding site [ion binding]; other site 405532004985 Mor transcription activator family; Region: Mor; cl02360 405532004986 Predicted membrane protein [Function unknown]; Region: COG2323 405532004987 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 405532004988 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405532004989 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405532004990 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405532004991 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405532004992 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405532004993 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405532004994 methionine sulfoxide reductase A; Provisional; Region: PRK14054 405532004995 short chain dehydrogenase; Provisional; Region: PRK12747 405532004996 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 405532004997 NADP binding site [chemical binding]; other site 405532004998 homodimer interface [polypeptide binding]; other site 405532004999 active site 405532005000 substrate binding site [chemical binding]; other site 405532005001 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405532005002 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405532005003 homodimer interface [polypeptide binding]; other site 405532005004 substrate-cofactor binding pocket; other site 405532005005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532005006 catalytic residue [active] 405532005007 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 405532005008 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405532005009 PYR/PP interface [polypeptide binding]; other site 405532005010 dimer interface [polypeptide binding]; other site 405532005011 TPP binding site [chemical binding]; other site 405532005012 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405532005013 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405532005014 TPP-binding site [chemical binding]; other site 405532005015 dimer interface [polypeptide binding]; other site 405532005016 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 405532005017 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 405532005018 putative valine binding site [chemical binding]; other site 405532005019 dimer interface [polypeptide binding]; other site 405532005020 ketol-acid reductoisomerase; Provisional; Region: PRK05479 405532005021 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 405532005022 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405532005023 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 405532005024 threonine dehydratase; Validated; Region: PRK08639 405532005025 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405532005026 tetramer interface [polypeptide binding]; other site 405532005027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532005028 catalytic residue [active] 405532005029 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 405532005030 putative Ile/Val binding site [chemical binding]; other site 405532005031 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 405532005032 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 405532005033 putative active site [active] 405532005034 putative metal binding site [ion binding]; other site 405532005035 Protein of unknown function (DUF554); Region: DUF554; pfam04474 405532005036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005037 Coenzyme A binding pocket [chemical binding]; other site 405532005038 drug efflux system protein MdtG; Provisional; Region: PRK09874 405532005039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532005040 putative substrate translocation pore; other site 405532005041 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 405532005042 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 405532005043 putative active site [active] 405532005044 metal binding site [ion binding]; metal-binding site 405532005045 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 405532005046 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405532005047 LytTr DNA-binding domain; Region: LytTR; pfam04397 405532005048 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405532005049 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 405532005050 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 405532005051 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 405532005052 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405532005053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005054 Coenzyme A binding pocket [chemical binding]; other site 405532005055 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 405532005056 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 405532005057 active site 405532005058 putative substrate binding pocket [chemical binding]; other site 405532005059 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532005060 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532005061 peptide binding site [polypeptide binding]; other site 405532005062 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532005063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005064 Coenzyme A binding pocket [chemical binding]; other site 405532005065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532005066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532005067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532005068 active site 405532005069 phosphorylation site [posttranslational modification] 405532005070 intermolecular recognition site; other site 405532005071 dimerization interface [polypeptide binding]; other site 405532005072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532005073 DNA binding site [nucleotide binding] 405532005074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532005075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532005076 dimerization interface [polypeptide binding]; other site 405532005077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532005078 dimer interface [polypeptide binding]; other site 405532005079 phosphorylation site [posttranslational modification] 405532005080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532005081 ATP binding site [chemical binding]; other site 405532005082 Mg2+ binding site [ion binding]; other site 405532005083 G-X-G motif; other site 405532005084 Peptidase family M23; Region: Peptidase_M23; pfam01551 405532005085 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405532005086 manganese transport protein MntH; Reviewed; Region: PRK00701 405532005087 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 405532005088 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 405532005089 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 405532005090 active site residue [active] 405532005091 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 405532005092 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 405532005093 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405532005094 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405532005095 ydaO/yuaA leader 405532005096 Amino acid permease; Region: AA_permease_2; pfam13520 405532005097 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405532005098 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405532005099 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405532005100 Peptidase M60-like family; Region: M60-like; pfam13402 405532005101 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 405532005102 sugar binding site [chemical binding]; other site 405532005103 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405532005104 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405532005105 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 405532005106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532005107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532005108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005109 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532005110 Coenzyme A binding pocket [chemical binding]; other site 405532005111 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 405532005112 CAAX protease self-immunity; Region: Abi; pfam02517 405532005113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532005114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532005115 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405532005116 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532005117 DNA binding residues [nucleotide binding] 405532005118 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405532005119 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 405532005120 intersubunit interface [polypeptide binding]; other site 405532005121 active site 405532005122 catalytic residue [active] 405532005123 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405532005124 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405532005125 Nucleoside recognition; Region: Gate; pfam07670 405532005126 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405532005127 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 405532005128 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405532005129 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405532005130 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 405532005131 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405532005132 active site 405532005133 catalytic motif [active] 405532005134 Zn binding site [ion binding]; other site 405532005135 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405532005136 hypothetical protein; Provisional; Region: PRK01631 405532005137 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 405532005138 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532005139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532005140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532005141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532005142 dimerization interface [polypeptide binding]; other site 405532005143 Family description; Region: DsbD_2; pfam13386 405532005144 VPS10 domain; Region: VPS10; smart00602 405532005145 proline aminopeptidase P II; Provisional; Region: PRK10879 405532005146 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 405532005147 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 405532005148 active site 405532005149 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405532005150 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405532005151 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 405532005152 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 405532005153 Multicopper oxidase; Region: Cu-oxidase; pfam00394 405532005154 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 405532005155 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532005156 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532005157 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532005158 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532005159 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532005160 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405532005161 Peptidase family M23; Region: Peptidase_M23; pfam01551 405532005162 DNA topoisomerase III; Provisional; Region: PRK07726 405532005163 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405532005164 active site 405532005165 putative interdomain interaction site [polypeptide binding]; other site 405532005166 putative metal-binding site [ion binding]; other site 405532005167 putative nucleotide binding site [chemical binding]; other site 405532005168 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405532005169 domain I; other site 405532005170 DNA binding groove [nucleotide binding] 405532005171 phosphate binding site [ion binding]; other site 405532005172 domain II; other site 405532005173 domain III; other site 405532005174 nucleotide binding site [chemical binding]; other site 405532005175 catalytic site [active] 405532005176 domain IV; other site 405532005177 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405532005178 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405532005179 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 405532005180 Sodium Bile acid symporter family; Region: SBF; cl17470 405532005181 azoreductase; Provisional; Region: PRK13555 405532005182 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405532005183 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532005184 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 405532005185 dimer interface [polypeptide binding]; other site 405532005186 substrate binding site [chemical binding]; other site 405532005187 metal binding site [ion binding]; metal-binding site 405532005188 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 405532005189 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 405532005190 YtkA-like; Region: YtkA; pfam13115 405532005191 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 405532005192 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532005193 EamA-like transporter family; Region: EamA; pfam00892 405532005194 EamA-like transporter family; Region: EamA; pfam00892 405532005195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532005196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532005197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532005198 dimerization interface [polypeptide binding]; other site 405532005199 Predicted transcriptional regulator [Transcription]; Region: COG1959 405532005200 Transcriptional regulator; Region: Rrf2; pfam02082 405532005201 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405532005202 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 405532005203 catalytic residues [active] 405532005204 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405532005205 dimer interface [polypeptide binding]; other site 405532005206 FMN binding site [chemical binding]; other site 405532005207 amidase; Provisional; Region: PRK06707 405532005208 Amidase; Region: Amidase; cl11426 405532005209 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405532005210 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405532005211 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405532005212 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405532005213 NAD binding site [chemical binding]; other site 405532005214 dimer interface [polypeptide binding]; other site 405532005215 substrate binding site [chemical binding]; other site 405532005216 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 405532005217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405532005218 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405532005219 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 405532005220 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 405532005221 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 405532005222 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 405532005223 putative ligand binding site [chemical binding]; other site 405532005224 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 405532005225 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 405532005226 Walker A/P-loop; other site 405532005227 ATP binding site [chemical binding]; other site 405532005228 Q-loop/lid; other site 405532005229 ABC transporter signature motif; other site 405532005230 Walker B; other site 405532005231 D-loop; other site 405532005232 H-loop/switch region; other site 405532005233 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 405532005234 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 405532005235 Walker A/P-loop; other site 405532005236 ATP binding site [chemical binding]; other site 405532005237 Q-loop/lid; other site 405532005238 ABC transporter signature motif; other site 405532005239 Walker B; other site 405532005240 D-loop; other site 405532005241 H-loop/switch region; other site 405532005242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405532005243 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 405532005244 TM-ABC transporter signature motif; other site 405532005245 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 405532005246 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 405532005247 TM-ABC transporter signature motif; other site 405532005248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532005249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532005250 LysR substrate binding domain; Region: LysR_substrate; pfam03466 405532005251 dimerization interface [polypeptide binding]; other site 405532005252 lipoprotein; Provisional; Region: PRK10540 405532005253 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 405532005254 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532005255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532005256 putative Zn2+ binding site [ion binding]; other site 405532005257 putative DNA binding site [nucleotide binding]; other site 405532005258 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 405532005259 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 405532005260 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 405532005261 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 405532005262 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 405532005263 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405532005264 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 405532005265 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 405532005266 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532005267 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 405532005268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532005269 Walker A/P-loop; other site 405532005270 ATP binding site [chemical binding]; other site 405532005271 Q-loop/lid; other site 405532005272 ABC transporter signature motif; other site 405532005273 Walker B; other site 405532005274 D-loop; other site 405532005275 H-loop/switch region; other site 405532005276 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 405532005277 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532005278 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 405532005279 Walker A/P-loop; other site 405532005280 ATP binding site [chemical binding]; other site 405532005281 Q-loop/lid; other site 405532005282 ABC transporter signature motif; other site 405532005283 Walker B; other site 405532005284 D-loop; other site 405532005285 H-loop/switch region; other site 405532005286 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405532005287 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405532005288 active site 405532005289 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405532005290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532005291 active site 405532005292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532005293 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532005294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405532005295 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405532005296 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405532005297 inhibitor-cofactor binding pocket; inhibition site 405532005298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532005299 catalytic residue [active] 405532005300 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405532005301 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 405532005302 trimer interface [polypeptide binding]; other site 405532005303 active site 405532005304 substrate binding site [chemical binding]; other site 405532005305 CoA binding site [chemical binding]; other site 405532005306 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 405532005307 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405532005308 putative dimer interface [polypeptide binding]; other site 405532005309 catalytic triad [active] 405532005310 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532005311 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405532005312 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405532005313 dimer interface [polypeptide binding]; other site 405532005314 FMN binding site [chemical binding]; other site 405532005315 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532005316 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532005317 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532005318 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405532005319 NlpC/P60 family; Region: NLPC_P60; pfam00877 405532005320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532005321 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405532005322 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532005323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532005324 Walker A/P-loop; other site 405532005325 ATP binding site [chemical binding]; other site 405532005326 Q-loop/lid; other site 405532005327 ABC transporter signature motif; other site 405532005328 Walker B; other site 405532005329 D-loop; other site 405532005330 H-loop/switch region; other site 405532005331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532005332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532005333 active site 405532005334 phosphorylation site [posttranslational modification] 405532005335 intermolecular recognition site; other site 405532005336 dimerization interface [polypeptide binding]; other site 405532005337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532005338 DNA binding site [nucleotide binding] 405532005339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532005340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532005341 dimerization interface [polypeptide binding]; other site 405532005342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532005343 dimer interface [polypeptide binding]; other site 405532005344 phosphorylation site [posttranslational modification] 405532005345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532005346 ATP binding site [chemical binding]; other site 405532005347 Mg2+ binding site [ion binding]; other site 405532005348 G-X-G motif; other site 405532005349 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 405532005350 classical (c) SDRs; Region: SDR_c; cd05233 405532005351 NAD(P) binding site [chemical binding]; other site 405532005352 active site 405532005353 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 405532005354 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405532005355 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 405532005356 NodB motif; other site 405532005357 active site 405532005358 catalytic site [active] 405532005359 metal binding site [ion binding]; metal-binding site 405532005360 SdpI/YhfL protein family; Region: SdpI; pfam13630 405532005361 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 405532005362 nudix motif; other site 405532005363 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 405532005364 homoserine dehydrogenase; Provisional; Region: PRK06349 405532005365 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405532005366 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405532005367 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 405532005368 threonine synthase; Reviewed; Region: PRK06721 405532005369 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 405532005370 homodimer interface [polypeptide binding]; other site 405532005371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532005372 catalytic residue [active] 405532005373 homoserine kinase; Provisional; Region: PRK01212 405532005374 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405532005375 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405532005376 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 405532005377 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405532005378 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532005379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532005380 active site 405532005381 phosphorylation site [posttranslational modification] 405532005382 intermolecular recognition site; other site 405532005383 dimerization interface [polypeptide binding]; other site 405532005384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532005385 DNA binding site [nucleotide binding] 405532005386 HAMP domain; Region: HAMP; pfam00672 405532005387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532005388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532005389 dimer interface [polypeptide binding]; other site 405532005390 phosphorylation site [posttranslational modification] 405532005391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532005392 ATP binding site [chemical binding]; other site 405532005393 Mg2+ binding site [ion binding]; other site 405532005394 G-X-G motif; other site 405532005395 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405532005396 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405532005397 NodB motif; other site 405532005398 active site 405532005399 catalytic site [active] 405532005400 Zn binding site [ion binding]; other site 405532005401 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 405532005402 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405532005403 MgtC family; Region: MgtC; pfam02308 405532005404 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405532005405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005406 Coenzyme A binding pocket [chemical binding]; other site 405532005407 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 405532005408 IucA / IucC family; Region: IucA_IucC; pfam04183 405532005409 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 405532005410 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 405532005411 IucA / IucC family; Region: IucA_IucC; pfam04183 405532005412 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 405532005413 acyl-CoA synthetase; Validated; Region: PRK08308 405532005414 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405532005415 acyl-activating enzyme (AAE) consensus motif; other site 405532005416 AMP binding site [chemical binding]; other site 405532005417 active site 405532005418 CoA binding site [chemical binding]; other site 405532005419 acyl carrier protein; Provisional; Region: PRK07639 405532005420 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 405532005421 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 405532005422 Metal-binding active site; metal-binding site 405532005423 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405532005424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532005425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532005426 putative substrate translocation pore; other site 405532005427 Lysine efflux permease [General function prediction only]; Region: COG1279 405532005428 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405532005429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532005430 DNA-binding site [nucleotide binding]; DNA binding site 405532005431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532005432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532005433 homodimer interface [polypeptide binding]; other site 405532005434 catalytic residue [active] 405532005435 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 405532005436 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 405532005437 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 405532005438 active site 405532005439 nucleophile elbow; other site 405532005440 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 405532005441 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405532005442 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 405532005443 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405532005444 nudix motif; other site 405532005445 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 405532005446 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 405532005447 homodimer interface [polypeptide binding]; other site 405532005448 NAD binding pocket [chemical binding]; other site 405532005449 ATP binding pocket [chemical binding]; other site 405532005450 Mg binding site [ion binding]; other site 405532005451 active-site loop [active] 405532005452 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405532005453 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405532005454 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 405532005455 active site 405532005456 catalytic residues [active] 405532005457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532005458 dimerization interface [polypeptide binding]; other site 405532005459 putative DNA binding site [nucleotide binding]; other site 405532005460 putative Zn2+ binding site [ion binding]; other site 405532005461 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405532005462 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405532005463 active site 405532005464 catalytic tetrad [active] 405532005465 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405532005466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532005467 putative substrate translocation pore; other site 405532005468 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 405532005469 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405532005470 DinB superfamily; Region: DinB_2; pfam12867 405532005471 GTPase RsgA; Reviewed; Region: PRK01889 405532005472 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405532005473 RNA binding site [nucleotide binding]; other site 405532005474 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405532005475 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405532005476 GTP/Mg2+ binding site [chemical binding]; other site 405532005477 G4 box; other site 405532005478 G5 box; other site 405532005479 G1 box; other site 405532005480 Switch I region; other site 405532005481 G2 box; other site 405532005482 G3 box; other site 405532005483 Switch II region; other site 405532005484 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 405532005485 Cache domain; Region: Cache_1; pfam02743 405532005486 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532005487 dimerization interface [polypeptide binding]; other site 405532005488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532005489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532005490 dimer interface [polypeptide binding]; other site 405532005491 putative CheW interface [polypeptide binding]; other site 405532005492 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 405532005493 Uncharacterized membrane protein [Function unknown]; Region: COG3949 405532005494 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405532005495 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405532005496 dimerization interface [polypeptide binding]; other site 405532005497 DPS ferroxidase diiron center [ion binding]; other site 405532005498 ion pore; other site 405532005499 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 405532005500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532005501 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 405532005502 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 405532005503 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 405532005504 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 405532005505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405532005506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532005507 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532005508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405532005509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405532005510 active site 405532005511 catalytic tetrad [active] 405532005512 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405532005513 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 405532005514 P-loop, Walker A motif; other site 405532005515 Base recognition motif; other site 405532005516 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 405532005517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405532005518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005519 Coenzyme A binding pocket [chemical binding]; other site 405532005520 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 405532005521 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 405532005522 metal binding site [ion binding]; metal-binding site 405532005523 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 405532005524 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405532005525 NAD binding site [chemical binding]; other site 405532005526 active site 405532005527 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405532005528 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 405532005529 active site 405532005530 FMN binding site [chemical binding]; other site 405532005531 substrate binding site [chemical binding]; other site 405532005532 homotetramer interface [polypeptide binding]; other site 405532005533 catalytic residue [active] 405532005534 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 405532005535 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405532005536 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405532005537 DNA binding site [nucleotide binding] 405532005538 active site 405532005539 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 405532005540 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532005541 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532005542 peptide binding site [polypeptide binding]; other site 405532005543 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 405532005544 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405532005545 active site 405532005546 metal binding site [ion binding]; metal-binding site 405532005547 short chain dehydrogenase; Provisional; Region: PRK08309 405532005548 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405532005549 catalytic core [active] 405532005550 CotH protein; Region: CotH; pfam08757 405532005551 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 405532005552 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 405532005553 nudix motif; other site 405532005554 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405532005555 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405532005556 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405532005557 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405532005558 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 405532005559 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 405532005560 Cl binding site [ion binding]; other site 405532005561 oligomer interface [polypeptide binding]; other site 405532005562 Predicted permeases [General function prediction only]; Region: COG0701 405532005563 Predicted membrane protein [Function unknown]; Region: COG3689 405532005564 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 405532005565 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 405532005566 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405532005567 putative active site [active] 405532005568 catalytic site [active] 405532005569 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405532005570 putative active site [active] 405532005571 catalytic site [active] 405532005572 Coat F domain; Region: Coat_F; pfam07875 405532005573 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405532005574 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405532005575 NAD binding site [chemical binding]; other site 405532005576 substrate binding site [chemical binding]; other site 405532005577 putative active site [active] 405532005578 Protein of unknown function (DUF456); Region: DUF456; pfam04306 405532005579 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405532005580 Domain of unknown function DUF21; Region: DUF21; pfam01595 405532005581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405532005582 Transporter associated domain; Region: CorC_HlyC; smart01091 405532005583 FOG: CBS domain [General function prediction only]; Region: COG0517 405532005584 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405532005585 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405532005586 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 405532005587 dimer interface [polypeptide binding]; other site 405532005588 putative tRNA-binding site [nucleotide binding]; other site 405532005589 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 405532005590 DinB superfamily; Region: DinB_2; pfam12867 405532005591 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 405532005592 stage II sporulation protein P; Region: spore_II_P; TIGR02867 405532005593 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532005594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005595 Coenzyme A binding pocket [chemical binding]; other site 405532005596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532005597 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405532005598 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405532005599 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405532005600 nudix motif; other site 405532005601 amidase; Provisional; Region: PRK06828 405532005602 Amidase; Region: Amidase; pfam01425 405532005603 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532005604 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 405532005605 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405532005606 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 405532005607 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 405532005608 stage II sporulation protein P; Region: spore_II_P; TIGR02867 405532005609 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405532005610 catalytic core [active] 405532005611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532005612 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405532005613 active site 405532005614 motif I; other site 405532005615 motif II; other site 405532005616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532005617 multidrug resistance protein MdtH; Provisional; Region: PRK11646 405532005618 DinB superfamily; Region: DinB_2; pfam12867 405532005619 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 405532005620 alanine racemase; Reviewed; Region: alr; PRK00053 405532005621 active site 405532005622 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405532005623 dimer interface [polypeptide binding]; other site 405532005624 substrate binding site [chemical binding]; other site 405532005625 catalytic residues [active] 405532005626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005627 Coenzyme A binding pocket [chemical binding]; other site 405532005628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005629 Coenzyme A binding pocket [chemical binding]; other site 405532005630 active site 405532005631 ATP binding site [chemical binding]; other site 405532005632 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405532005633 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405532005634 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405532005635 active site 405532005636 TDP-binding site; other site 405532005637 acceptor substrate-binding pocket; other site 405532005638 homodimer interface [polypeptide binding]; other site 405532005639 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532005640 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532005641 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532005642 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405532005643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532005644 DNA-binding site [nucleotide binding]; DNA binding site 405532005645 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532005646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532005647 homodimer interface [polypeptide binding]; other site 405532005648 catalytic residue [active] 405532005649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005650 Coenzyme A binding pocket [chemical binding]; other site 405532005651 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532005652 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 405532005653 active site 405532005654 metal binding site [ion binding]; metal-binding site 405532005655 Src Homology 3 domain superfamily; Region: SH3; cl17036 405532005656 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532005657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005658 Coenzyme A binding pocket [chemical binding]; other site 405532005659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532005660 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 405532005661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405532005662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005663 Coenzyme A binding pocket [chemical binding]; other site 405532005664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005665 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532005666 Coenzyme A binding pocket [chemical binding]; other site 405532005667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 405532005668 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 405532005669 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405532005670 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; pfam10661 405532005671 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 405532005672 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 405532005673 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 405532005674 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 405532005675 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 405532005676 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405532005677 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405532005678 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 405532005679 LXG domain of WXG superfamily; Region: LXG; pfam04740 405532005680 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 405532005681 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 405532005682 Predicted acetyltransferase [General function prediction only]; Region: COG3393 405532005683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532005685 Coenzyme A binding pocket [chemical binding]; other site 405532005686 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405532005687 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532005688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532005689 S-adenosylmethionine binding site [chemical binding]; other site 405532005690 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 405532005691 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 405532005692 Potassium binding sites [ion binding]; other site 405532005693 Cesium cation binding sites [ion binding]; other site 405532005694 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405532005695 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405532005696 ATP binding site [chemical binding]; other site 405532005697 putative Mg++ binding site [ion binding]; other site 405532005698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532005699 nucleotide binding region [chemical binding]; other site 405532005700 ATP-binding site [chemical binding]; other site 405532005701 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 405532005702 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532005703 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 405532005704 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405532005705 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 405532005706 NADP binding site [chemical binding]; other site 405532005707 dimer interface [polypeptide binding]; other site 405532005708 RNA polymerase sigma factor; Provisional; Region: PRK12543 405532005709 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532005710 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532005711 DNA binding residues [nucleotide binding] 405532005712 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 405532005713 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 405532005714 ABC1 family; Region: ABC1; cl17513 405532005715 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 405532005716 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532005717 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 405532005718 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 405532005719 catalytic residues [active] 405532005720 dimer interface [polypeptide binding]; other site 405532005721 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 405532005722 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405532005723 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 405532005724 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405532005725 Protein of unknown function DUF58; Region: DUF58; pfam01882 405532005726 MoxR-like ATPases [General function prediction only]; Region: COG0714 405532005727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532005728 Walker A motif; other site 405532005729 ATP binding site [chemical binding]; other site 405532005730 Walker B motif; other site 405532005731 arginine finger; other site 405532005732 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 405532005733 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 405532005734 [4Fe-4S] binding site [ion binding]; other site 405532005735 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405532005736 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405532005737 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405532005738 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 405532005739 molybdopterin cofactor binding site; other site 405532005740 nitrate reductase, beta subunit; Region: narH; TIGR01660 405532005741 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 405532005742 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 405532005743 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405532005744 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405532005745 ligand binding site [chemical binding]; other site 405532005746 flexible hinge region; other site 405532005747 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 405532005748 putative switch regulator; other site 405532005749 non-specific DNA interactions [nucleotide binding]; other site 405532005750 DNA binding site [nucleotide binding] 405532005751 sequence specific DNA binding site [nucleotide binding]; other site 405532005752 putative cAMP binding site [chemical binding]; other site 405532005753 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 405532005754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532005755 FeS/SAM binding site; other site 405532005756 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405532005757 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405532005758 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405532005759 ATP binding site [chemical binding]; other site 405532005760 substrate interface [chemical binding]; other site 405532005761 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405532005762 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405532005763 dimer interface [polypeptide binding]; other site 405532005764 putative functional site; other site 405532005765 putative MPT binding site; other site 405532005766 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405532005767 MoaE homodimer interface [polypeptide binding]; other site 405532005768 MoaD interaction [polypeptide binding]; other site 405532005769 active site residues [active] 405532005770 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405532005771 MoaE interaction surface [polypeptide binding]; other site 405532005772 MoeB interaction surface [polypeptide binding]; other site 405532005773 thiocarboxylated glycine; other site 405532005774 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 405532005775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532005776 putative substrate translocation pore; other site 405532005777 Predicted permeases [General function prediction only]; Region: COG0679 405532005778 precorrin-2 dehydrogenase; Validated; Region: PRK06719 405532005779 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 405532005780 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 405532005781 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 405532005782 putative active site [active] 405532005783 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 405532005784 putative active site [active] 405532005785 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 405532005786 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 405532005787 active site 405532005788 SAM binding site [chemical binding]; other site 405532005789 homodimer interface [polypeptide binding]; other site 405532005790 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 405532005791 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 405532005792 [2Fe-2S] cluster binding site [ion binding]; other site 405532005793 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 405532005794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532005795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532005796 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405532005797 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405532005798 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405532005799 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 405532005800 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 405532005801 Hemerythrin-like domain; Region: Hr-like; cd12108 405532005802 Excalibur calcium-binding domain; Region: Excalibur; smart00894 405532005803 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 405532005804 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 405532005805 PGAP1-like protein; Region: PGAP1; pfam07819 405532005806 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 405532005807 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 405532005808 metal binding site [ion binding]; metal-binding site 405532005809 putative transposase OrfB; Reviewed; Region: PHA02517 405532005810 HTH-like domain; Region: HTH_21; pfam13276 405532005811 Integrase core domain; Region: rve; pfam00665 405532005812 Integrase core domain; Region: rve_2; pfam13333 405532005813 HTH-like domain; Region: HTH_21; pfam13276 405532005814 Integrase core domain; Region: rve; pfam00665 405532005815 Integrase core domain; Region: rve_3; pfam13683 405532005816 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532005817 Winged helix-turn helix; Region: HTH_29; pfam13551 405532005818 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 405532005819 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532005820 Zn2+ binding site [ion binding]; other site 405532005821 Mg2+ binding site [ion binding]; other site 405532005822 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405532005823 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532005824 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532005825 ABC transporter; Region: ABC_tran_2; pfam12848 405532005826 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532005827 Bax inhibitor 1 like; Region: BaxI_1; cl17691 405532005828 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 405532005829 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405532005830 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405532005831 dimer interface [polypeptide binding]; other site 405532005832 ssDNA binding site [nucleotide binding]; other site 405532005833 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405532005834 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 405532005835 Virulence factor; Region: Virulence_fact; pfam13769 405532005836 HEAT repeats; Region: HEAT_2; pfam13646 405532005837 HEAT repeats; Region: HEAT_2; pfam13646 405532005838 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 405532005839 Protein of unknown function, DUF393; Region: DUF393; pfam04134 405532005840 Disulphide isomerase; Region: Disulph_isomer; pfam06491 405532005841 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 405532005842 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 405532005843 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405532005844 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405532005845 active site 405532005846 HIGH motif; other site 405532005847 KMSK motif region; other site 405532005848 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 405532005849 tRNA binding surface [nucleotide binding]; other site 405532005850 anticodon binding site; other site 405532005851 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 405532005852 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405532005853 Methyltransferase domain; Region: Methyltransf_12; pfam08242 405532005854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532005855 binding surface 405532005856 TPR motif; other site 405532005857 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405532005858 putative active site [active] 405532005859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532005860 binding surface 405532005861 TPR motif; other site 405532005862 TPR repeat; Region: TPR_11; pfam13414 405532005863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532005864 binding surface 405532005865 TPR motif; other site 405532005866 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405532005867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532005868 binding surface 405532005869 TPR motif; other site 405532005870 TPR repeat; Region: TPR_11; pfam13414 405532005871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532005872 binding surface 405532005873 TPR motif; other site 405532005874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532005875 binding surface 405532005876 TPR motif; other site 405532005877 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405532005878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532005879 binding surface 405532005880 TPR motif; other site 405532005881 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 405532005882 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405532005883 HIGH motif; other site 405532005884 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405532005885 active site 405532005886 KMSKS motif; other site 405532005887 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 405532005888 tRNA binding surface [nucleotide binding]; other site 405532005889 anticodon binding site; other site 405532005890 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 405532005891 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405532005892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532005893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532005894 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405532005895 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405532005896 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405532005897 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 405532005898 Zn binding site [ion binding]; other site 405532005899 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 405532005900 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 405532005901 Dimer interface [polypeptide binding]; other site 405532005902 anticodon binding site; other site 405532005903 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405532005904 homodimer interface [polypeptide binding]; other site 405532005905 motif 1; other site 405532005906 motif 2; other site 405532005907 active site 405532005908 motif 3; other site 405532005909 glycerate kinase; Region: TIGR00045 405532005910 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405532005911 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 405532005912 transmembrane helices; other site 405532005913 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532005914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532005915 active site 405532005916 phosphorylation site [posttranslational modification] 405532005917 intermolecular recognition site; other site 405532005918 dimerization interface [polypeptide binding]; other site 405532005919 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532005920 DNA binding site [nucleotide binding] 405532005921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532005922 HAMP domain; Region: HAMP; pfam00672 405532005923 dimerization interface [polypeptide binding]; other site 405532005924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532005925 dimer interface [polypeptide binding]; other site 405532005926 phosphorylation site [posttranslational modification] 405532005927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532005928 ATP binding site [chemical binding]; other site 405532005929 Mg2+ binding site [ion binding]; other site 405532005930 G-X-G motif; other site 405532005931 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405532005932 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405532005933 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405532005934 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405532005935 Na2 binding site [ion binding]; other site 405532005936 putative substrate binding site 1 [chemical binding]; other site 405532005937 Na binding site 1 [ion binding]; other site 405532005938 putative substrate binding site 2 [chemical binding]; other site 405532005939 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532005940 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 405532005941 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 405532005942 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405532005943 Eukaryotic phosphomannomutase; Region: PMM; cl17107 405532005944 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405532005945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532005946 motif II; other site 405532005947 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 405532005948 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405532005949 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 405532005950 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 405532005951 putative active site [active] 405532005952 metal binding site [ion binding]; metal-binding site 405532005953 aspartate racemase; Region: asp_race; TIGR00035 405532005954 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 405532005955 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 405532005956 homodimer interaction site [polypeptide binding]; other site 405532005957 cofactor binding site; other site 405532005958 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405532005959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005960 Coenzyme A binding pocket [chemical binding]; other site 405532005961 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 405532005962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532005963 salt bridge; other site 405532005964 non-specific DNA binding site [nucleotide binding]; other site 405532005965 sequence-specific DNA binding site [nucleotide binding]; other site 405532005966 hypothetical protein; Validated; Region: PRK06769 405532005967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532005968 active site 405532005969 motif I; other site 405532005970 motif II; other site 405532005971 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532005972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532005973 Coenzyme A binding pocket [chemical binding]; other site 405532005974 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405532005975 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532005976 Walker A/P-loop; other site 405532005977 ATP binding site [chemical binding]; other site 405532005978 Q-loop/lid; other site 405532005979 ABC transporter signature motif; other site 405532005980 Walker B; other site 405532005981 D-loop; other site 405532005982 H-loop/switch region; other site 405532005983 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405532005984 YpjP-like protein; Region: YpjP; pfam14005 405532005985 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405532005986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532005987 motif II; other site 405532005988 hypothetical protein; Provisional; Region: PRK06724 405532005989 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532005990 active site 405532005991 metal binding site [ion binding]; metal-binding site 405532005992 Phosphotransferase enzyme family; Region: APH; pfam01636 405532005993 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405532005994 active site 405532005995 substrate binding site [chemical binding]; other site 405532005996 ATP binding site [chemical binding]; other site 405532005997 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532005998 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532005999 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 405532006000 thymidylate synthase; Region: thym_sym; TIGR03284 405532006001 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 405532006002 dimerization interface [polypeptide binding]; other site 405532006003 active site 405532006004 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405532006005 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 405532006006 folate binding site [chemical binding]; other site 405532006007 NADP+ binding site [chemical binding]; other site 405532006008 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 405532006009 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532006010 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405532006011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532006012 azoreductase; Reviewed; Region: PRK00170 405532006013 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405532006014 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405532006015 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405532006016 putative acyl-acceptor binding pocket; other site 405532006017 Haemolysin-III related; Region: HlyIII; cl03831 405532006018 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405532006019 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 405532006020 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 405532006021 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 405532006022 EDD domain protein, DegV family; Region: DegV; TIGR00762 405532006023 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405532006024 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405532006025 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405532006026 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 405532006027 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 405532006028 Cu(I) binding site [ion binding]; other site 405532006029 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405532006030 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405532006031 putative dimer interface [polypeptide binding]; other site 405532006032 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 405532006033 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405532006034 active site 405532006035 dimer interface [polypeptide binding]; other site 405532006036 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405532006037 Ligand Binding Site [chemical binding]; other site 405532006038 Molecular Tunnel; other site 405532006039 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532006040 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405532006041 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405532006042 active site 405532006043 metal binding site [ion binding]; metal-binding site 405532006044 Bacterial SH3 domain; Region: SH3_3; cl17532 405532006045 Bacterial SH3 domain; Region: SH3_3; cl17532 405532006046 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405532006047 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405532006048 siderophore binding site; other site 405532006049 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405532006050 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405532006051 homodimer interface [polypeptide binding]; other site 405532006052 substrate-cofactor binding pocket; other site 405532006053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532006054 catalytic residue [active] 405532006055 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 405532006056 FMN binding site [chemical binding]; other site 405532006057 dimer interface [polypeptide binding]; other site 405532006058 Isochorismatase family; Region: Isochorismatase; pfam00857 405532006059 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405532006060 catalytic triad [active] 405532006061 conserved cis-peptide bond; other site 405532006062 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405532006063 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 405532006064 putative dimer interface [polypeptide binding]; other site 405532006065 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405532006066 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405532006067 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405532006068 GAF domain; Region: GAF; pfam01590 405532006069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405532006070 Histidine kinase; Region: HisKA_3; pfam07730 405532006071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532006072 ATP binding site [chemical binding]; other site 405532006073 Mg2+ binding site [ion binding]; other site 405532006074 G-X-G motif; other site 405532006075 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405532006076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532006077 active site 405532006078 phosphorylation site [posttranslational modification] 405532006079 intermolecular recognition site; other site 405532006080 dimerization interface [polypeptide binding]; other site 405532006081 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405532006082 DNA binding residues [nucleotide binding] 405532006083 dimerization interface [polypeptide binding]; other site 405532006084 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405532006085 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405532006086 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405532006087 putative active site [active] 405532006088 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 405532006089 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405532006090 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 405532006091 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 405532006092 NAD binding site [chemical binding]; other site 405532006093 substrate binding site [chemical binding]; other site 405532006094 catalytic Zn binding site [ion binding]; other site 405532006095 tetramer interface [polypeptide binding]; other site 405532006096 structural Zn binding site [ion binding]; other site 405532006097 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532006098 Winged helix-turn helix; Region: HTH_29; pfam13551 405532006099 HTH-like domain; Region: HTH_21; pfam13276 405532006100 Integrase core domain; Region: rve; pfam00665 405532006101 Integrase core domain; Region: rve_3; pfam13683 405532006102 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405532006103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532006104 dimer interface [polypeptide binding]; other site 405532006105 conserved gate region; other site 405532006106 ABC-ATPase subunit interface; other site 405532006107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532006108 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405532006109 dimer interface [polypeptide binding]; other site 405532006110 conserved gate region; other site 405532006111 putative PBP binding loops; other site 405532006112 ABC-ATPase subunit interface; other site 405532006113 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 405532006114 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 405532006115 N- and C-terminal domain interface [polypeptide binding]; other site 405532006116 active site 405532006117 catalytic site [active] 405532006118 metal binding site [ion binding]; metal-binding site 405532006119 carbohydrate binding site [chemical binding]; other site 405532006120 ATP binding site [chemical binding]; other site 405532006121 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405532006122 GntP family permease; Region: GntP_permease; pfam02447 405532006123 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 405532006124 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405532006125 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 405532006126 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405532006127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532006128 active site 405532006129 Predicted flavoprotein [General function prediction only]; Region: COG0431 405532006130 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405532006131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532006132 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532006133 putative substrate translocation pore; other site 405532006134 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405532006135 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405532006136 putative active site [active] 405532006137 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 405532006138 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 405532006139 Walker A/P-loop; other site 405532006140 ATP binding site [chemical binding]; other site 405532006141 Q-loop/lid; other site 405532006142 ABC transporter signature motif; other site 405532006143 Walker B; other site 405532006144 D-loop; other site 405532006145 H-loop/switch region; other site 405532006146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532006147 dimer interface [polypeptide binding]; other site 405532006148 conserved gate region; other site 405532006149 ABC-ATPase subunit interface; other site 405532006150 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 405532006151 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 405532006152 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405532006153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405532006154 Protein of unknown function (DUF524); Region: DUF524; pfam04411 405532006155 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 405532006156 Helix-turn-helix domain; Region: HTH_17; pfam12728 405532006157 Haemagglutinin; Region: Hemagglutinin; pfam00509 405532006158 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405532006159 Domain of unknown function DUF21; Region: DUF21; pfam01595 405532006160 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405532006161 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 405532006162 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405532006163 NAD(P) binding site [chemical binding]; other site 405532006164 catalytic residues [active] 405532006165 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 405532006166 Histidine kinase N terminal; Region: HisK_N; pfam09385 405532006167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532006168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532006169 dimer interface [polypeptide binding]; other site 405532006170 phosphorylation site [posttranslational modification] 405532006171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532006172 ATP binding site [chemical binding]; other site 405532006173 Mg2+ binding site [ion binding]; other site 405532006174 G-X-G motif; other site 405532006175 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 405532006176 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 405532006177 hypothetical protein; Provisional; Region: PRK06917 405532006178 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405532006179 inhibitor-cofactor binding pocket; inhibition site 405532006180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532006181 catalytic residue [active] 405532006182 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 405532006183 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 405532006184 acetylornithine deacetylase; Validated; Region: PRK06915 405532006185 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 405532006186 metal binding site [ion binding]; metal-binding site 405532006187 dimer interface [polypeptide binding]; other site 405532006188 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 405532006189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532006190 Coenzyme A binding pocket [chemical binding]; other site 405532006191 PAS fold; Region: PAS_4; pfam08448 405532006192 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 405532006193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532006194 Walker A motif; other site 405532006195 ATP binding site [chemical binding]; other site 405532006196 Walker B motif; other site 405532006197 arginine finger; other site 405532006198 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405532006199 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 405532006200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532006201 FeS/SAM binding site; other site 405532006202 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 405532006203 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 405532006204 toxin interface [polypeptide binding]; other site 405532006205 Zn binding site [ion binding]; other site 405532006206 hypothetical protein; Provisional; Region: PRK13672 405532006207 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 405532006208 YozD-like protein; Region: YozD; pfam14162 405532006209 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 405532006210 Catalytic domain of Protein Kinases; Region: PKc; cd00180 405532006211 active site 405532006212 ATP binding site [chemical binding]; other site 405532006213 substrate binding site [chemical binding]; other site 405532006214 activation loop (A-loop); other site 405532006215 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 405532006216 SpoOM protein; Region: Spo0M; pfam07070 405532006217 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405532006218 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405532006219 active site 405532006220 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405532006221 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 405532006222 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405532006223 catalytic residues [active] 405532006224 C1q domain; Region: C1q; cl17543 405532006225 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405532006226 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405532006227 active site 405532006228 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 405532006229 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405532006230 YolD-like protein; Region: YolD; pfam08863 405532006231 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405532006232 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 405532006233 classical (c) SDRs; Region: SDR_c; cd05233 405532006234 NAD(P) binding site [chemical binding]; other site 405532006235 active site 405532006236 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 405532006237 KTSC domain; Region: KTSC; pfam13619 405532006238 Transglycosylase; Region: Transgly; pfam00912 405532006239 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405532006240 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532006241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532006242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532006243 putative substrate translocation pore; other site 405532006244 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 405532006245 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 405532006246 dimer interface [polypeptide binding]; other site 405532006247 Citrate synthase; Region: Citrate_synt; pfam00285 405532006248 active site 405532006249 coenzyme A binding site [chemical binding]; other site 405532006250 citrylCoA binding site [chemical binding]; other site 405532006251 oxalacetate/citrate binding site [chemical binding]; other site 405532006252 catalytic triad [active] 405532006253 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 405532006254 2-methylcitrate dehydratase; Region: prpD; TIGR02330 405532006255 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 405532006256 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405532006257 tetramer interface [polypeptide binding]; other site 405532006258 active site 405532006259 Mg2+/Mn2+ binding site [ion binding]; other site 405532006260 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405532006261 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405532006262 active site 405532006263 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 405532006264 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405532006265 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 405532006266 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 405532006267 tetrameric interface [polypeptide binding]; other site 405532006268 NAD binding site [chemical binding]; other site 405532006269 catalytic residues [active] 405532006270 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 405532006271 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 405532006272 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405532006273 substrate binding site [chemical binding]; other site 405532006274 oxyanion hole (OAH) forming residues; other site 405532006275 trimer interface [polypeptide binding]; other site 405532006276 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 405532006277 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 405532006278 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 405532006279 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405532006280 active site 405532006281 metal binding site [ion binding]; metal-binding site 405532006282 DNA binding site [nucleotide binding] 405532006283 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 405532006284 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 405532006285 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 405532006286 Walker A/P-loop; other site 405532006287 ATP binding site [chemical binding]; other site 405532006288 Q-loop/lid; other site 405532006289 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 405532006290 ABC transporter signature motif; other site 405532006291 Walker B; other site 405532006292 D-loop; other site 405532006293 H-loop/switch region; other site 405532006294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532006295 dimerization interface [polypeptide binding]; other site 405532006296 putative DNA binding site [nucleotide binding]; other site 405532006297 putative Zn2+ binding site [ion binding]; other site 405532006298 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 405532006299 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 405532006300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532006301 putative substrate translocation pore; other site 405532006302 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 405532006303 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 405532006304 putative NAD(P) binding site [chemical binding]; other site 405532006305 active site 405532006306 isochorismate synthase DhbC; Validated; Region: PRK06923 405532006307 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405532006308 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 405532006309 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 405532006310 acyl-activating enzyme (AAE) consensus motif; other site 405532006311 active site 405532006312 AMP binding site [chemical binding]; other site 405532006313 substrate binding site [chemical binding]; other site 405532006314 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 405532006315 hydrophobic substrate binding pocket; other site 405532006316 Isochorismatase family; Region: Isochorismatase; pfam00857 405532006317 active site 405532006318 conserved cis-peptide bond; other site 405532006319 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 405532006320 Condensation domain; Region: Condensation; pfam00668 405532006321 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 405532006322 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405532006323 acyl-activating enzyme (AAE) consensus motif; other site 405532006324 AMP binding site [chemical binding]; other site 405532006325 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532006326 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 405532006327 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405532006328 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405532006329 acyl-activating enzyme (AAE) consensus motif; other site 405532006330 AMP binding site [chemical binding]; other site 405532006331 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532006332 MbtH-like protein; Region: MbtH; pfam03621 405532006333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532006334 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532006335 putative substrate translocation pore; other site 405532006336 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 405532006337 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 405532006338 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405532006339 IHF dimer interface [polypeptide binding]; other site 405532006340 IHF - DNA interface [nucleotide binding]; other site 405532006341 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 405532006342 DinB family; Region: DinB; cl17821 405532006343 DinB superfamily; Region: DinB_2; pfam12867 405532006344 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405532006345 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 405532006346 active site 405532006347 catalytic triad [active] 405532006348 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405532006349 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405532006350 Glycine riboswitch 405532006351 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 405532006352 metal binding triad [ion binding]; metal-binding site 405532006353 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 405532006354 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405532006355 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532006356 RNA binding surface [nucleotide binding]; other site 405532006357 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 405532006358 probable active site [active] 405532006359 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 405532006360 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405532006361 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405532006362 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405532006363 active site 405532006364 dimer interface [polypeptide binding]; other site 405532006365 motif 1; other site 405532006366 motif 2; other site 405532006367 motif 3; other site 405532006368 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405532006369 anticodon binding site; other site 405532006370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532006371 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532006372 Walker A/P-loop; other site 405532006373 ATP binding site [chemical binding]; other site 405532006374 Q-loop/lid; other site 405532006375 ABC transporter signature motif; other site 405532006376 Walker B; other site 405532006377 D-loop; other site 405532006378 H-loop/switch region; other site 405532006379 FtsX-like permease family; Region: FtsX; pfam02687 405532006380 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532006381 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405532006382 dimer interface [polypeptide binding]; other site 405532006383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405532006384 conserved gate region; other site 405532006385 ABC-ATPase subunit interface; other site 405532006386 pyruvate oxidase; Provisional; Region: PRK08611 405532006387 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 405532006388 PYR/PP interface [polypeptide binding]; other site 405532006389 dimer interface [polypeptide binding]; other site 405532006390 tetramer interface [polypeptide binding]; other site 405532006391 TPP binding site [chemical binding]; other site 405532006392 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405532006393 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 405532006394 TPP-binding site [chemical binding]; other site 405532006395 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 405532006396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532006397 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405532006398 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 405532006399 active site 405532006400 dimerization interface [polypeptide binding]; other site 405532006401 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 405532006402 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405532006403 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405532006404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405532006405 ligand binding site [chemical binding]; other site 405532006406 flexible hinge region; other site 405532006407 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 405532006408 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405532006409 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 405532006410 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405532006411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532006412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532006413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532006414 MMPL family; Region: MMPL; pfam03176 405532006415 MMPL family; Region: MMPL; pfam03176 405532006416 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 405532006417 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 405532006418 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 405532006419 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405532006420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532006421 Coenzyme A binding pocket [chemical binding]; other site 405532006422 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405532006423 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405532006424 putative acetyltransferase YhhY; Provisional; Region: PRK10140 405532006425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532006426 Coenzyme A binding pocket [chemical binding]; other site 405532006427 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532006428 EamA-like transporter family; Region: EamA; pfam00892 405532006429 EamA-like transporter family; Region: EamA; pfam00892 405532006430 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405532006431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532006432 non-specific DNA binding site [nucleotide binding]; other site 405532006433 salt bridge; other site 405532006434 sequence-specific DNA binding site [nucleotide binding]; other site 405532006435 Cupin domain; Region: Cupin_2; pfam07883 405532006436 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405532006437 protoporphyrinogen oxidase; Provisional; Region: PRK12416 405532006438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405532006439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532006440 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532006441 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532006442 Cold-inducible protein YdjO; Region: YdjO; pfam14169 405532006443 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405532006444 DNA-binding site [nucleotide binding]; DNA binding site 405532006445 RNA-binding motif; other site 405532006446 CAAX protease self-immunity; Region: Abi; pfam02517 405532006447 AAA domain; Region: AAA_17; pfam13207 405532006448 AAA domain; Region: AAA_18; pfam13238 405532006449 hypothetical protein; Provisional; Region: PRK06770 405532006450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532006451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532006452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532006453 dimerization interface [polypeptide binding]; other site 405532006454 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 405532006455 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405532006456 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405532006457 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 405532006458 active site 405532006459 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 405532006460 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 405532006461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532006462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532006463 dimerization interface [polypeptide binding]; other site 405532006464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 405532006465 MOSC domain; Region: MOSC; pfam03473 405532006466 3-alpha domain; Region: 3-alpha; pfam03475 405532006467 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 405532006468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532006469 Coenzyme A binding pocket [chemical binding]; other site 405532006470 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 405532006471 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405532006472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532006473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532006474 Walker A/P-loop; other site 405532006475 ATP binding site [chemical binding]; other site 405532006476 Q-loop/lid; other site 405532006477 ABC transporter signature motif; other site 405532006478 Walker B; other site 405532006479 D-loop; other site 405532006480 H-loop/switch region; other site 405532006481 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405532006482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532006483 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405532006484 Walker A/P-loop; other site 405532006485 ATP binding site [chemical binding]; other site 405532006486 Q-loop/lid; other site 405532006487 ABC transporter signature motif; other site 405532006488 Walker B; other site 405532006489 D-loop; other site 405532006490 H-loop/switch region; other site 405532006491 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 405532006492 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 405532006493 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 405532006494 BclB C-terminal domain; Region: exospore_TM; TIGR03721 405532006495 Cupin; Region: Cupin_1; smart00835 405532006496 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 405532006497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405532006498 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 405532006499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532006500 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405532006501 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405532006502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532006503 S-adenosylmethionine binding site [chemical binding]; other site 405532006504 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 405532006505 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 405532006506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 405532006507 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 405532006508 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405532006509 active site 405532006510 P-loop; other site 405532006511 phosphorylation site [posttranslational modification] 405532006512 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405532006513 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405532006514 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 405532006515 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 405532006516 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 405532006517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 405532006518 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 405532006519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532006520 catalytic residue [active] 405532006521 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 405532006522 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405532006523 tetramer interface [polypeptide binding]; other site 405532006524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532006525 catalytic residue [active] 405532006526 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532006527 MarR family; Region: MarR; pfam01047 405532006528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532006529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532006530 putative substrate translocation pore; other site 405532006531 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532006532 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 405532006533 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405532006534 ATP binding site [chemical binding]; other site 405532006535 Mg++ binding site [ion binding]; other site 405532006536 motif III; other site 405532006537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532006538 nucleotide binding region [chemical binding]; other site 405532006539 ATP-binding site [chemical binding]; other site 405532006540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532006541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532006542 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532006543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 405532006544 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532006545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532006546 S-adenosylmethionine binding site [chemical binding]; other site 405532006547 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405532006548 dimer interface [polypeptide binding]; other site 405532006549 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405532006550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532006551 S-adenosylmethionine binding site [chemical binding]; other site 405532006552 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 405532006553 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 405532006554 dimer interface [polypeptide binding]; other site 405532006555 PYR/PP interface [polypeptide binding]; other site 405532006556 TPP binding site [chemical binding]; other site 405532006557 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405532006558 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 405532006559 TPP-binding site [chemical binding]; other site 405532006560 dimer interface [polypeptide binding]; other site 405532006561 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532006562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532006563 putative DNA binding site [nucleotide binding]; other site 405532006564 putative Zn2+ binding site [ion binding]; other site 405532006565 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405532006566 catalytic core [active] 405532006567 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405532006568 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 405532006569 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405532006570 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 405532006571 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 405532006572 metal binding site [ion binding]; metal-binding site 405532006573 dimer interface [polypeptide binding]; other site 405532006574 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 405532006575 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 405532006576 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 405532006577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405532006578 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405532006579 DNA binding residues [nucleotide binding] 405532006580 dimerization interface [polypeptide binding]; other site 405532006581 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532006582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532006583 non-specific DNA binding site [nucleotide binding]; other site 405532006584 salt bridge; other site 405532006585 sequence-specific DNA binding site [nucleotide binding]; other site 405532006586 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405532006587 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405532006588 hypothetical protein; Provisional; Region: PRK10621 405532006589 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405532006590 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405532006591 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 405532006592 trimer interface [polypeptide binding]; other site 405532006593 active site 405532006594 substrate binding site [chemical binding]; other site 405532006595 CoA binding site [chemical binding]; other site 405532006596 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405532006597 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532006598 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405532006599 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 405532006600 active site 405532006601 catalytic triad [active] 405532006602 oxyanion hole [active] 405532006603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532006604 putative substrate translocation pore; other site 405532006605 Condensation domain; Region: Condensation; pfam00668 405532006606 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405532006607 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405532006608 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405532006609 acyl-activating enzyme (AAE) consensus motif; other site 405532006610 AMP binding site [chemical binding]; other site 405532006611 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532006612 Condensation domain; Region: Condensation; pfam00668 405532006613 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405532006614 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 405532006615 Condensation domain; Region: Condensation; pfam00668 405532006616 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405532006617 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405532006618 acyl-activating enzyme (AAE) consensus motif; other site 405532006619 AMP binding site [chemical binding]; other site 405532006620 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532006621 Condensation domain; Region: Condensation; pfam00668 405532006622 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405532006623 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405532006624 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 405532006625 acyl-activating enzyme (AAE) consensus motif; other site 405532006626 AMP binding site [chemical binding]; other site 405532006627 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532006628 Condensation domain; Region: Condensation; pfam00668 405532006629 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405532006630 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405532006631 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405532006632 acyl-activating enzyme (AAE) consensus motif; other site 405532006633 AMP binding site [chemical binding]; other site 405532006634 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532006635 peptide synthase; Provisional; Region: PRK12467 405532006636 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405532006637 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405532006638 acyl-activating enzyme (AAE) consensus motif; other site 405532006639 AMP binding site [chemical binding]; other site 405532006640 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532006641 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405532006642 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405532006643 acyl-activating enzyme (AAE) consensus motif; other site 405532006644 AMP binding site [chemical binding]; other site 405532006645 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532006646 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 405532006647 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405532006648 acyl-activating enzyme (AAE) consensus motif; other site 405532006649 AMP binding site [chemical binding]; other site 405532006650 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405532006651 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 405532006652 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 405532006653 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 405532006654 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 405532006655 Erythromycin esterase; Region: Erythro_esteras; cl17110 405532006656 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405532006657 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405532006658 catalytic residue [active] 405532006659 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532006660 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532006661 S-layer homology domain; Region: SLH; pfam00395 405532006662 S-layer homology domain; Region: SLH; pfam00395 405532006663 S-layer homology domain; Region: SLH; pfam00395 405532006664 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 405532006665 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 405532006666 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 405532006667 active site 405532006668 nucleophile elbow; other site 405532006669 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405532006670 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 405532006671 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 405532006672 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405532006673 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 405532006674 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 405532006675 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 405532006676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532006677 FeS/SAM binding site; other site 405532006678 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405532006679 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405532006680 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 405532006681 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 405532006682 iron-sulfur cluster [ion binding]; other site 405532006683 [2Fe-2S] cluster binding site [ion binding]; other site 405532006684 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 405532006685 hydrophobic ligand binding site; other site 405532006686 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 405532006687 ykoK leader 405532006688 ykoK leader 405532006689 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 405532006690 MgtE intracellular N domain; Region: MgtE_N; pfam03448 405532006691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 405532006692 Divalent cation transporter; Region: MgtE; pfam01769 405532006693 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 405532006694 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 405532006695 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405532006696 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532006697 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532006698 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405532006699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532006700 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532006701 DNA binding residues [nucleotide binding] 405532006702 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405532006703 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532006704 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532006705 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405532006706 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532006707 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532006708 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532006709 beta-lactamase TEM; Provisional; Region: PRK15442 405532006710 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405532006711 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405532006712 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532006713 putative active site [active] 405532006714 putative metal binding site [ion binding]; other site 405532006715 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532006716 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405532006717 Walker A/P-loop; other site 405532006718 ATP binding site [chemical binding]; other site 405532006719 Q-loop/lid; other site 405532006720 ABC transporter signature motif; other site 405532006721 Walker B; other site 405532006722 D-loop; other site 405532006723 H-loop/switch region; other site 405532006724 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405532006725 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405532006726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532006727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532006728 Protein of unknown function (DUF523); Region: DUF523; pfam04463 405532006729 Uncharacterized conserved protein [Function unknown]; Region: COG3272 405532006730 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 405532006731 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405532006732 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405532006733 FAD binding site [chemical binding]; other site 405532006734 homotetramer interface [polypeptide binding]; other site 405532006735 substrate binding pocket [chemical binding]; other site 405532006736 catalytic base [active] 405532006737 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 405532006738 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405532006739 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405532006740 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405532006741 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405532006742 carboxyltransferase (CT) interaction site; other site 405532006743 biotinylation site [posttranslational modification]; other site 405532006744 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 405532006745 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 405532006746 active site 405532006747 catalytic residues [active] 405532006748 metal binding site [ion binding]; metal-binding site 405532006749 enoyl-CoA hydratase; Provisional; Region: PRK07657 405532006750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405532006751 substrate binding site [chemical binding]; other site 405532006752 oxyanion hole (OAH) forming residues; other site 405532006753 trimer interface [polypeptide binding]; other site 405532006754 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 405532006755 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 405532006756 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 405532006757 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 405532006758 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 405532006759 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 405532006760 acyl-activating enzyme (AAE) consensus motif; other site 405532006761 putative AMP binding site [chemical binding]; other site 405532006762 putative active site [active] 405532006763 putative CoA binding site [chemical binding]; other site 405532006764 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532006765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532006766 Coenzyme A binding pocket [chemical binding]; other site 405532006767 hypothetical protein; Provisional; Region: PRK08233 405532006768 AAA domain; Region: AAA_18; pfam13238 405532006769 active site 405532006770 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 405532006771 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405532006772 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532006773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532006774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532006775 dimer interface [polypeptide binding]; other site 405532006776 phosphorylation site [posttranslational modification] 405532006777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532006778 ATP binding site [chemical binding]; other site 405532006779 Mg2+ binding site [ion binding]; other site 405532006780 G-X-G motif; other site 405532006781 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532006782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532006783 active site 405532006784 phosphorylation site [posttranslational modification] 405532006785 intermolecular recognition site; other site 405532006786 dimerization interface [polypeptide binding]; other site 405532006787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532006788 DNA binding site [nucleotide binding] 405532006789 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 405532006790 Zn2+ binding site [ion binding]; other site 405532006791 Mg2+ binding site [ion binding]; other site 405532006792 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 405532006793 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 405532006794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532006795 Coenzyme A binding pocket [chemical binding]; other site 405532006796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532006797 Coenzyme A binding pocket [chemical binding]; other site 405532006798 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532006799 Winged helix-turn helix; Region: HTH_29; pfam13551 405532006800 HTH-like domain; Region: HTH_21; pfam13276 405532006801 Integrase core domain; Region: rve; pfam00665 405532006802 Integrase core domain; Region: rve_3; pfam13683 405532006803 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405532006804 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405532006805 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405532006806 active site 405532006807 Zn binding site [ion binding]; other site 405532006808 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 405532006809 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 405532006810 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405532006811 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405532006812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532006813 Cna protein B-type domain; Region: Cna_B; pfam05738 405532006814 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405532006815 Cna protein B-type domain; Region: Cna_B; pfam05738 405532006816 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405532006817 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 405532006818 active site 405532006819 catalytic site [active] 405532006820 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 405532006821 Cna protein B-type domain; Region: Cna_B; pfam05738 405532006822 Cna protein B-type domain; Region: Cna_B; pfam05738 405532006823 Cna protein B-type domain; Region: Cna_B; pfam05738 405532006824 Cna protein B-type domain; Region: Cna_B; pfam05738 405532006825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405532006826 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 405532006827 putative hydrophobic ligand binding site [chemical binding]; other site 405532006828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532006829 AAA domain; Region: AAA_21; pfam13304 405532006830 Walker A/P-loop; other site 405532006831 ATP binding site [chemical binding]; other site 405532006832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532006833 ABC transporter signature motif; other site 405532006834 Walker B; other site 405532006835 D-loop; other site 405532006836 H-loop/switch region; other site 405532006837 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 405532006838 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 405532006839 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 405532006840 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532006841 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405532006842 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 405532006843 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532006844 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532006845 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405532006846 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405532006847 DNA binding residues [nucleotide binding] 405532006848 drug binding residues [chemical binding]; other site 405532006849 dimer interface [polypeptide binding]; other site 405532006850 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405532006851 short chain dehydrogenase; Provisional; Region: PRK07041 405532006852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532006853 NAD(P) binding site [chemical binding]; other site 405532006854 active site 405532006855 Predicted transcriptional regulators [Transcription]; Region: COG1733 405532006856 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405532006857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532006858 S-adenosylmethionine binding site [chemical binding]; other site 405532006859 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405532006860 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532006861 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405532006862 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405532006863 active site 405532006864 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405532006865 active site 405532006866 substrate binding site [chemical binding]; other site 405532006867 ATP binding site [chemical binding]; other site 405532006868 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 405532006869 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405532006870 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405532006871 active site 405532006872 Zn binding site [ion binding]; other site 405532006873 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 405532006874 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405532006875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532006876 DNA-binding site [nucleotide binding]; DNA binding site 405532006877 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532006878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532006879 homodimer interface [polypeptide binding]; other site 405532006880 catalytic residue [active] 405532006881 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 405532006882 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 405532006883 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 405532006884 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 405532006885 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405532006886 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405532006887 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 405532006888 putative NAD(P) binding site [chemical binding]; other site 405532006889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532006890 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405532006891 NAD(P) binding site [chemical binding]; other site 405532006892 active site 405532006893 Predicted membrane protein [Function unknown]; Region: COG2323 405532006894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532006895 S-adenosylmethionine binding site [chemical binding]; other site 405532006896 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532006897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532006898 S-adenosylmethionine binding site [chemical binding]; other site 405532006899 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 405532006900 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 405532006901 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 405532006902 active site 405532006903 HIGH motif; other site 405532006904 KMSKS motif; other site 405532006905 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405532006906 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 405532006907 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532006908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532006909 active site 405532006910 phosphorylation site [posttranslational modification] 405532006911 intermolecular recognition site; other site 405532006912 dimerization interface [polypeptide binding]; other site 405532006913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532006914 DNA binding site [nucleotide binding] 405532006915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532006916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 405532006917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532006918 ATP binding site [chemical binding]; other site 405532006919 Mg2+ binding site [ion binding]; other site 405532006920 G-X-G motif; other site 405532006921 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405532006922 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532006923 ABC transporter; Region: ABC_tran_2; pfam12848 405532006924 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532006925 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532006926 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532006927 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532006928 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532006929 Walker A/P-loop; other site 405532006930 ATP binding site [chemical binding]; other site 405532006931 Q-loop/lid; other site 405532006932 ABC transporter signature motif; other site 405532006933 Walker B; other site 405532006934 D-loop; other site 405532006935 H-loop/switch region; other site 405532006936 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405532006937 FtsX-like permease family; Region: FtsX; pfam02687 405532006938 hypothetical protein; Provisional; Region: PRK06760 405532006939 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 405532006940 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 405532006941 homoserine dehydrogenase; Validated; Region: PRK06813 405532006942 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405532006943 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405532006944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532006945 DNA-binding site [nucleotide binding]; DNA binding site 405532006946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532006947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532006948 homodimer interface [polypeptide binding]; other site 405532006949 catalytic residue [active] 405532006950 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 405532006951 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405532006952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405532006953 Putative transcription activator [Transcription]; Region: TenA; COG0819 405532006954 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 405532006955 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 405532006956 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 405532006957 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 405532006958 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 405532006959 Int/Topo IB signature motif; other site 405532006960 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532006961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532006962 non-specific DNA binding site [nucleotide binding]; other site 405532006963 salt bridge; other site 405532006964 sequence-specific DNA binding site [nucleotide binding]; other site 405532006965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532006966 non-specific DNA binding site [nucleotide binding]; other site 405532006967 salt bridge; other site 405532006968 sequence-specific DNA binding site [nucleotide binding]; other site 405532006969 Helix-turn-helix domain; Region: HTH_17; pfam12728 405532006970 Helix-turn-helix domain; Region: HTH_36; pfam13730 405532006971 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405532006972 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 405532006973 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405532006974 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405532006975 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 405532006976 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 405532006977 putative metal binding site [ion binding]; other site 405532006978 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 405532006979 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 405532006980 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 405532006981 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405532006982 Int/Topo IB signature motif; other site 405532006983 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405532006984 active site 405532006985 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405532006986 active site 405532006987 Phage terminase, small subunit; Region: Terminase_4; pfam05119 405532006988 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405532006989 Phage portal protein; Region: Phage_portal; pfam04860 405532006990 Phage-related protein [Function unknown]; Region: COG4695 405532006991 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 405532006992 oligomer interface [polypeptide binding]; other site 405532006993 active site residues [active] 405532006994 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405532006995 Phage capsid family; Region: Phage_capsid; pfam05065 405532006996 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 405532006997 oligomerization interface [polypeptide binding]; other site 405532006998 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 405532006999 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 405532007000 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 405532007001 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 405532007002 tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979 405532007003 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 405532007004 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 405532007005 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405532007006 Phage-related protein [Function unknown]; Region: COG5412 405532007007 Phage tail protein; Region: Sipho_tail; pfam05709 405532007008 Phage tail protein; Region: Sipho_tail; cl17486 405532007009 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 405532007010 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405532007011 Haemolysin XhlA; Region: XhlA; pfam10779 405532007012 Phage lysis protein, holin; Region: Phage_holin; cl04675 405532007013 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405532007014 amidase catalytic site [active] 405532007015 Zn binding residues [ion binding]; other site 405532007016 substrate binding site [chemical binding]; other site 405532007017 Bacterial SH3 domain; Region: SH3_3; cl17532 405532007018 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532007019 YolD-like protein; Region: YolD; pfam08863 405532007020 Predicted membrane protein [Function unknown]; Region: COG2323 405532007021 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 405532007022 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 405532007023 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 405532007024 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 405532007025 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 405532007026 Protein of unknown function; Region: DUF3658; pfam12395 405532007027 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405532007028 Cytochrome P450; Region: p450; cl12078 405532007029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007030 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532007031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007032 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 405532007033 trimer interface [polypeptide binding]; other site 405532007034 active site 405532007035 substrate binding site [chemical binding]; other site 405532007036 CoA binding site [chemical binding]; other site 405532007037 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 405532007038 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532007039 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405532007040 Cytochrome P450; Region: p450; cl12078 405532007041 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405532007042 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 405532007043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532007044 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405532007045 active site 405532007046 motif I; other site 405532007047 motif II; other site 405532007048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532007049 PAS domain S-box; Region: sensory_box; TIGR00229 405532007050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532007051 putative active site [active] 405532007052 heme pocket [chemical binding]; other site 405532007053 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405532007054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532007055 dimer interface [polypeptide binding]; other site 405532007056 phosphorylation site [posttranslational modification] 405532007057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532007058 ATP binding site [chemical binding]; other site 405532007059 Mg2+ binding site [ion binding]; other site 405532007060 G-X-G motif; other site 405532007061 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405532007062 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532007063 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532007064 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532007065 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405532007066 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405532007067 Catalytic site [active] 405532007068 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405532007069 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405532007070 active site 405532007071 TDP-binding site; other site 405532007072 acceptor substrate-binding pocket; other site 405532007073 homodimer interface [polypeptide binding]; other site 405532007074 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 405532007075 aspartate racemase; Region: asp_race; TIGR00035 405532007076 hypothetical protein; Provisional; Region: PRK13661 405532007077 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405532007078 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405532007079 Walker A/P-loop; other site 405532007080 ATP binding site [chemical binding]; other site 405532007081 Q-loop/lid; other site 405532007082 ABC transporter signature motif; other site 405532007083 Walker B; other site 405532007084 D-loop; other site 405532007085 H-loop/switch region; other site 405532007086 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 405532007087 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405532007088 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405532007089 Walker A/P-loop; other site 405532007090 ATP binding site [chemical binding]; other site 405532007091 Q-loop/lid; other site 405532007092 ABC transporter signature motif; other site 405532007093 Walker B; other site 405532007094 D-loop; other site 405532007095 H-loop/switch region; other site 405532007096 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405532007097 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405532007098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532007099 dimer interface [polypeptide binding]; other site 405532007100 phosphorylation site [posttranslational modification] 405532007101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532007102 ATP binding site [chemical binding]; other site 405532007103 Mg2+ binding site [ion binding]; other site 405532007104 G-X-G motif; other site 405532007105 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 405532007106 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405532007107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532007108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532007109 active site 405532007110 phosphorylation site [posttranslational modification] 405532007111 intermolecular recognition site; other site 405532007112 dimerization interface [polypeptide binding]; other site 405532007113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532007114 DNA binding site [nucleotide binding] 405532007115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532007116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532007117 dimerization interface [polypeptide binding]; other site 405532007118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532007119 dimer interface [polypeptide binding]; other site 405532007120 phosphorylation site [posttranslational modification] 405532007121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532007122 ATP binding site [chemical binding]; other site 405532007123 Mg2+ binding site [ion binding]; other site 405532007124 G-X-G motif; other site 405532007125 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405532007126 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405532007127 NAD(P) binding site [chemical binding]; other site 405532007128 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 405532007129 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405532007130 active site 405532007131 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405532007132 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532007133 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532007134 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 405532007135 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 405532007136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007137 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532007138 putative substrate translocation pore; other site 405532007139 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532007140 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532007141 VanZ like family; Region: VanZ; pfam04892 405532007142 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 405532007143 EDD domain protein, DegV family; Region: DegV; TIGR00762 405532007144 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405532007145 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405532007146 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405532007147 DNA binding residues [nucleotide binding] 405532007148 Trm112p-like protein; Region: Trm112p; pfam03966 405532007149 Methyltransferase domain; Region: Methyltransf_26; pfam13659 405532007150 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532007151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007153 Coenzyme A binding pocket [chemical binding]; other site 405532007154 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 405532007155 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405532007156 active site 405532007157 catalytic site [active] 405532007158 metal binding site [ion binding]; metal-binding site 405532007159 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 405532007160 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532007161 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532007162 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 405532007163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532007164 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405532007165 DNA-binding site [nucleotide binding]; DNA binding site 405532007166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532007167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532007168 homodimer interface [polypeptide binding]; other site 405532007169 catalytic residue [active] 405532007170 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405532007171 EamA-like transporter family; Region: EamA; pfam00892 405532007172 EamA-like transporter family; Region: EamA; pfam00892 405532007173 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 405532007174 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405532007175 active site 405532007176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007177 Coenzyme A binding pocket [chemical binding]; other site 405532007178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 405532007179 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 405532007180 nudix motif; other site 405532007181 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 405532007182 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532007183 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532007184 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 405532007185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007186 putative substrate translocation pore; other site 405532007187 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405532007188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007189 Coenzyme A binding pocket [chemical binding]; other site 405532007190 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405532007191 nudix motif; other site 405532007192 DNA polymerase III subunit beta; Validated; Region: PRK06673 405532007193 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405532007194 putative DNA binding surface [nucleotide binding]; other site 405532007195 dimer interface [polypeptide binding]; other site 405532007196 beta-clamp/clamp loader binding surface; other site 405532007197 beta-clamp/translesion DNA polymerase binding surface; other site 405532007198 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405532007199 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405532007200 translation initiation factor IF-2; Provisional; Region: PRK14845 405532007201 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405532007202 homotrimer interaction site [polypeptide binding]; other site 405532007203 putative active site [active] 405532007204 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 405532007205 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405532007206 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 405532007207 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 405532007208 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 405532007209 YxiJ-like protein; Region: YxiJ; pfam14176 405532007210 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405532007211 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405532007212 active site 405532007213 nucleophile elbow; other site 405532007214 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 405532007215 pentamer interface [polypeptide binding]; other site 405532007216 dodecaamer interface [polypeptide binding]; other site 405532007217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007218 Coenzyme A binding pocket [chemical binding]; other site 405532007219 metal-dependent hydrolase; Provisional; Region: PRK13291 405532007220 DinB superfamily; Region: DinB_2; pfam12867 405532007221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532007222 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532007223 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 405532007224 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405532007225 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405532007226 GIY-YIG motif/motif A; other site 405532007227 active site 405532007228 catalytic site [active] 405532007229 putative DNA binding site [nucleotide binding]; other site 405532007230 metal binding site [ion binding]; metal-binding site 405532007231 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532007232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007233 Coenzyme A binding pocket [chemical binding]; other site 405532007234 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 405532007235 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 405532007236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405532007237 active site 405532007238 ATP binding site [chemical binding]; other site 405532007239 substrate binding site [chemical binding]; other site 405532007240 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 405532007241 nudix motif; other site 405532007242 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405532007243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405532007244 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 405532007245 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 405532007246 MepB protein; Region: MepB; pfam08877 405532007247 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 405532007248 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 405532007249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532007250 motif II; other site 405532007251 DinB superfamily; Region: DinB_2; pfam12867 405532007252 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 405532007253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532007254 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 405532007255 carbohydrate binding site [chemical binding]; other site 405532007256 pullulanase, type I; Region: pulA_typeI; TIGR02104 405532007257 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 405532007258 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 405532007259 Ca binding site [ion binding]; other site 405532007260 active site 405532007261 catalytic site [active] 405532007262 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 405532007263 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405532007264 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405532007265 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405532007266 active site 405532007267 Zn binding site [ion binding]; other site 405532007268 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405532007269 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405532007270 active site 405532007271 metal binding site [ion binding]; metal-binding site 405532007272 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405532007273 DinB superfamily; Region: DinB_2; pfam12867 405532007274 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 405532007275 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 405532007276 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405532007277 active site 405532007278 metal binding site [ion binding]; metal-binding site 405532007279 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532007280 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 405532007281 SecY translocase; Region: SecY; pfam00344 405532007282 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 405532007283 EamA-like transporter family; Region: EamA; pfam00892 405532007284 EamA-like transporter family; Region: EamA; pfam00892 405532007285 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405532007286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532007287 DNA-binding site [nucleotide binding]; DNA binding site 405532007288 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532007289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532007290 homodimer interface [polypeptide binding]; other site 405532007291 catalytic residue [active] 405532007292 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532007293 TAP-like protein; Region: Abhydrolase_4; pfam08386 405532007294 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405532007295 Mg binding site [ion binding]; other site 405532007296 nucleotide binding site [chemical binding]; other site 405532007297 putative protofilament interface [polypeptide binding]; other site 405532007298 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 405532007299 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405532007300 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532007301 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 405532007302 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405532007303 germination protein YpeB; Region: spore_YpeB; TIGR02889 405532007304 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 405532007305 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405532007306 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405532007307 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 405532007308 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532007309 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532007310 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 405532007311 arylformamidase; Region: trp_arylform; TIGR03035 405532007312 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405532007313 kynureninase; Region: kynureninase; TIGR01814 405532007314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532007315 catalytic residue [active] 405532007316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532007317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532007318 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 405532007319 hydrophobic ligand binding site; other site 405532007320 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 405532007321 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 405532007322 GAF domain; Region: GAF; pfam01590 405532007323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532007324 Walker A motif; other site 405532007325 ATP binding site [chemical binding]; other site 405532007326 Walker B motif; other site 405532007327 arginine finger; other site 405532007328 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405532007329 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405532007330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007331 Coenzyme A binding pocket [chemical binding]; other site 405532007332 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405532007333 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 405532007334 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405532007335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532007336 S-adenosylmethionine binding site [chemical binding]; other site 405532007337 Rrf2 family protein; Region: rrf2_super; TIGR00738 405532007338 Transcriptional regulator; Region: Rrf2; pfam02082 405532007339 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 405532007340 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 405532007341 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 405532007342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532007343 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405532007344 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405532007345 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405532007346 E3 interaction surface; other site 405532007347 lipoyl attachment site [posttranslational modification]; other site 405532007348 e3 binding domain; Region: E3_binding; pfam02817 405532007349 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405532007350 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405532007351 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405532007352 alpha subunit interface [polypeptide binding]; other site 405532007353 TPP binding site [chemical binding]; other site 405532007354 heterodimer interface [polypeptide binding]; other site 405532007355 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405532007356 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 405532007357 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405532007358 tetramer interface [polypeptide binding]; other site 405532007359 TPP-binding site [chemical binding]; other site 405532007360 heterodimer interface [polypeptide binding]; other site 405532007361 phosphorylation loop region [posttranslational modification] 405532007362 DinB superfamily; Region: DinB_2; pfam12867 405532007363 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 405532007364 short chain dehydrogenase; Provisional; Region: PRK06914 405532007365 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 405532007366 NADP binding site [chemical binding]; other site 405532007367 active site 405532007368 steroid binding site; other site 405532007369 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405532007370 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 405532007371 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405532007372 nudix motif; other site 405532007373 Protein phosphatase 2C; Region: PP2C_2; pfam13672 405532007374 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 405532007375 nucleotide binding site/active site [active] 405532007376 HIT family signature motif; other site 405532007377 catalytic residue [active] 405532007378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532007379 dimer interface [polypeptide binding]; other site 405532007380 conserved gate region; other site 405532007381 putative PBP binding loops; other site 405532007382 ABC-ATPase subunit interface; other site 405532007383 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 405532007384 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 405532007385 Walker A/P-loop; other site 405532007386 ATP binding site [chemical binding]; other site 405532007387 Q-loop/lid; other site 405532007388 ABC transporter signature motif; other site 405532007389 Walker B; other site 405532007390 D-loop; other site 405532007391 H-loop/switch region; other site 405532007392 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 405532007393 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 405532007394 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 405532007395 Clp protease; Region: CLP_protease; pfam00574 405532007396 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405532007397 oligomer interface [polypeptide binding]; other site 405532007398 active site residues [active] 405532007399 RNA polymerase factor sigma-70; Validated; Region: PRK06704 405532007400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532007401 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405532007402 DNA binding residues [nucleotide binding] 405532007403 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 405532007404 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405532007405 catalytic loop [active] 405532007406 iron binding site [ion binding]; other site 405532007407 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 405532007408 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405532007409 active site 405532007410 dimer interface [polypeptide binding]; other site 405532007411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007412 Coenzyme A binding pocket [chemical binding]; other site 405532007413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 405532007414 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405532007415 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405532007416 Interdomain contacts; other site 405532007417 Cytokine receptor motif; other site 405532007418 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 405532007419 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405532007420 Interdomain contacts; other site 405532007421 Cytokine receptor motif; other site 405532007422 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 405532007423 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405532007424 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405532007425 active site 405532007426 TDP-binding site; other site 405532007427 acceptor substrate-binding pocket; other site 405532007428 homodimer interface [polypeptide binding]; other site 405532007429 Uncharacterized conserved protein [Function unknown]; Region: COG1262 405532007430 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 405532007431 topology modulation protein; Reviewed; Region: PRK08118 405532007432 AAA domain; Region: AAA_17; pfam13207 405532007433 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405532007434 Phosphotransferase enzyme family; Region: APH; pfam01636 405532007435 active site 405532007436 ATP binding site [chemical binding]; other site 405532007437 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 405532007438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532007439 S-adenosylmethionine binding site [chemical binding]; other site 405532007440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 405532007441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007442 Coenzyme A binding pocket [chemical binding]; other site 405532007443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007444 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532007445 Coenzyme A binding pocket [chemical binding]; other site 405532007446 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405532007447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007448 Coenzyme A binding pocket [chemical binding]; other site 405532007449 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532007450 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405532007451 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405532007452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007453 Coenzyme A binding pocket [chemical binding]; other site 405532007454 Predicted transcriptional regulator [Transcription]; Region: COG2378 405532007455 HTH domain; Region: HTH_11; pfam08279 405532007456 WYL domain; Region: WYL; pfam13280 405532007457 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 405532007458 Part of AAA domain; Region: AAA_19; pfam13245 405532007459 Family description; Region: UvrD_C_2; pfam13538 405532007460 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 405532007461 putative active site pocket [active] 405532007462 dimerization interface [polypeptide binding]; other site 405532007463 putative catalytic residue [active] 405532007464 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 405532007465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532007466 ATP binding site [chemical binding]; other site 405532007467 putative Mg++ binding site [ion binding]; other site 405532007468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532007469 nucleotide binding region [chemical binding]; other site 405532007470 ATP-binding site [chemical binding]; other site 405532007471 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 405532007472 HRDC domain; Region: HRDC; pfam00570 405532007473 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405532007474 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405532007475 active site 405532007476 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405532007477 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405532007478 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405532007479 active site 405532007480 metal binding site [ion binding]; metal-binding site 405532007481 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405532007482 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 405532007483 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 405532007484 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 405532007485 DHHA2 domain; Region: DHHA2; pfam02833 405532007486 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405532007487 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532007488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007489 Coenzyme A binding pocket [chemical binding]; other site 405532007490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532007491 Zn2+ binding site [ion binding]; other site 405532007492 Mg2+ binding site [ion binding]; other site 405532007493 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 405532007494 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405532007495 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405532007496 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 405532007497 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405532007498 NAD(P) binding site [chemical binding]; other site 405532007499 catalytic residues [active] 405532007500 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 405532007501 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 405532007502 inhibitor site; inhibition site 405532007503 active site 405532007504 dimer interface [polypeptide binding]; other site 405532007505 catalytic residue [active] 405532007506 Proline racemase; Region: Pro_racemase; pfam05544 405532007507 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405532007508 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405532007509 Proline racemase; Region: Pro_racemase; pfam05544 405532007510 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405532007511 hydroxyglutarate oxidase; Provisional; Region: PRK11728 405532007512 PAS domain; Region: PAS_9; pfam13426 405532007513 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 405532007514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532007515 Walker A motif; other site 405532007516 ATP binding site [chemical binding]; other site 405532007517 Walker B motif; other site 405532007518 arginine finger; other site 405532007519 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405532007520 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405532007521 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405532007522 catalytic loop [active] 405532007523 iron binding site [ion binding]; other site 405532007524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 405532007525 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 405532007526 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 405532007527 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 405532007528 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 405532007529 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532007530 active site 405532007531 metal binding site [ion binding]; metal-binding site 405532007532 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 405532007533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532007534 Zn2+ binding site [ion binding]; other site 405532007535 Mg2+ binding site [ion binding]; other site 405532007536 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405532007537 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405532007538 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 405532007539 DltD N-terminal region; Region: DltD_N; pfam04915 405532007540 DltD central region; Region: DltD_M; pfam04918 405532007541 DltD C-terminal region; Region: DltD_C; pfam04914 405532007542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532007543 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532007544 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532007545 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532007546 peptide binding site [polypeptide binding]; other site 405532007547 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405532007548 NlpC/P60 family; Region: NLPC_P60; pfam00877 405532007549 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 405532007550 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 405532007551 active site 405532007552 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 405532007553 Septum formation initiator; Region: DivIC; cl17659 405532007554 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405532007555 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405532007556 active site 405532007557 catalytic tetrad [active] 405532007558 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405532007559 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 405532007560 conserved cys residue [active] 405532007561 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 405532007562 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405532007563 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405532007564 AAA domain; Region: AAA_17; pfam13207 405532007565 AAA domain; Region: AAA_18; pfam13238 405532007566 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532007567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532007568 S-adenosylmethionine binding site [chemical binding]; other site 405532007569 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 405532007570 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 405532007571 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 405532007572 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405532007573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532007574 dimerization interface [polypeptide binding]; other site 405532007575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532007576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532007577 dimer interface [polypeptide binding]; other site 405532007578 phosphorylation site [posttranslational modification] 405532007579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532007580 ATP binding site [chemical binding]; other site 405532007581 Mg2+ binding site [ion binding]; other site 405532007582 G-X-G motif; other site 405532007583 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532007584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532007585 active site 405532007586 phosphorylation site [posttranslational modification] 405532007587 intermolecular recognition site; other site 405532007588 dimerization interface [polypeptide binding]; other site 405532007589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532007590 DNA binding site [nucleotide binding] 405532007591 DinB superfamily; Region: DinB_2; pfam12867 405532007592 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532007593 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405532007594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532007595 motif II; other site 405532007596 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 405532007597 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405532007598 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405532007599 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405532007600 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405532007601 Zn binding site [ion binding]; other site 405532007602 EDD domain protein, DegV family; Region: DegV; TIGR00762 405532007603 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405532007604 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 405532007605 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 405532007606 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 405532007607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007608 Coenzyme A binding pocket [chemical binding]; other site 405532007609 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 405532007610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532007612 putative substrate translocation pore; other site 405532007613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007614 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 405532007615 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 405532007616 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 405532007617 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 405532007618 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 405532007619 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 405532007620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007621 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532007622 putative substrate translocation pore; other site 405532007623 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 405532007624 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 405532007625 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405532007626 active site 405532007627 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 405532007628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532007629 S-adenosylmethionine binding site [chemical binding]; other site 405532007630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007631 putative substrate translocation pore; other site 405532007632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532007633 aspartate aminotransferase; Provisional; Region: PRK07681 405532007634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532007635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532007636 homodimer interface [polypeptide binding]; other site 405532007637 catalytic residue [active] 405532007638 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405532007639 pantothenate kinase; Provisional; Region: PRK13317 405532007640 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 405532007641 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 405532007642 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405532007643 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405532007644 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405532007645 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405532007646 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405532007647 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405532007648 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405532007649 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405532007650 HNH endonuclease; Region: HNH_5; pfam14279 405532007651 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 405532007652 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 405532007653 active site 405532007654 dimer interface [polypeptide binding]; other site 405532007655 non-prolyl cis peptide bond; other site 405532007656 insertion regions; other site 405532007657 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405532007658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405532007659 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 405532007660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405532007661 substrate binding pocket [chemical binding]; other site 405532007662 membrane-bound complex binding site; other site 405532007663 hinge residues; other site 405532007664 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405532007665 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405532007666 Walker A/P-loop; other site 405532007667 ATP binding site [chemical binding]; other site 405532007668 Q-loop/lid; other site 405532007669 ABC transporter signature motif; other site 405532007670 Walker B; other site 405532007671 D-loop; other site 405532007672 H-loop/switch region; other site 405532007673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532007674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532007675 Protein of unknown function (DUF402); Region: DUF402; pfam04167 405532007676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405532007677 binding surface 405532007678 TPR motif; other site 405532007679 hypothetical protein; Provisional; Region: PRK09620 405532007680 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 405532007681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007682 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532007683 Coenzyme A binding pocket [chemical binding]; other site 405532007684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532007685 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 405532007686 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405532007687 DinB superfamily; Region: DinB_2; pfam12867 405532007688 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405532007689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007690 Coenzyme A binding pocket [chemical binding]; other site 405532007691 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532007692 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532007693 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405532007694 active site 405532007695 NTP binding site [chemical binding]; other site 405532007696 metal binding triad [ion binding]; metal-binding site 405532007697 antibiotic binding site [chemical binding]; other site 405532007698 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405532007699 A new structural DNA glycosylase; Region: AlkD_like; cd06561 405532007700 active site 405532007701 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532007702 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405532007703 active site 405532007704 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405532007705 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405532007706 NodB motif; other site 405532007707 active site 405532007708 catalytic site [active] 405532007709 Zn binding site [ion binding]; other site 405532007710 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 405532007711 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 405532007712 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405532007713 Sulfatase; Region: Sulfatase; pfam00884 405532007714 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 405532007715 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532007716 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532007717 ABC transporter; Region: ABC_tran_2; pfam12848 405532007718 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532007719 MMPL family; Region: MMPL; pfam03176 405532007720 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 405532007721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532007722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532007723 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 405532007724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007725 Coenzyme A binding pocket [chemical binding]; other site 405532007726 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 405532007727 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 405532007728 hinge; other site 405532007729 active site 405532007730 prephenate dehydrogenase; Validated; Region: PRK06545 405532007731 prephenate dehydrogenase; Validated; Region: PRK08507 405532007732 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 405532007733 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 405532007734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532007735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532007736 homodimer interface [polypeptide binding]; other site 405532007737 catalytic residue [active] 405532007738 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 405532007739 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 405532007740 Tetramer interface [polypeptide binding]; other site 405532007741 active site 405532007742 FMN-binding site [chemical binding]; other site 405532007743 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 405532007744 Chorismate mutase type II; Region: CM_2; cl00693 405532007745 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 405532007746 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 405532007747 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 405532007748 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 405532007749 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405532007750 Isochorismatase family; Region: Isochorismatase; pfam00857 405532007751 catalytic triad [active] 405532007752 conserved cis-peptide bond; other site 405532007753 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532007754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007755 Coenzyme A binding pocket [chemical binding]; other site 405532007756 YfzA-like protein; Region: YfzA; pfam14118 405532007757 hypothetical protein; Provisional; Region: PRK06762 405532007758 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532007759 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532007760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405532007761 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 405532007762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532007763 putative metal binding site [ion binding]; other site 405532007764 Berberine and berberine like; Region: BBE; pfam08031 405532007765 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 405532007766 malate:quinone oxidoreductase; Validated; Region: PRK05257 405532007767 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 405532007768 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 405532007769 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 405532007770 ligand binding site [chemical binding]; other site 405532007771 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405532007772 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405532007773 TM-ABC transporter signature motif; other site 405532007774 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405532007775 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405532007776 TM-ABC transporter signature motif; other site 405532007777 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405532007778 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405532007779 Walker A/P-loop; other site 405532007780 ATP binding site [chemical binding]; other site 405532007781 Q-loop/lid; other site 405532007782 ABC transporter signature motif; other site 405532007783 Walker B; other site 405532007784 D-loop; other site 405532007785 H-loop/switch region; other site 405532007786 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405532007787 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405532007788 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405532007789 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 405532007790 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 405532007791 putative N- and C-terminal domain interface [polypeptide binding]; other site 405532007792 putative active site [active] 405532007793 putative MgATP binding site [chemical binding]; other site 405532007794 catalytic site [active] 405532007795 metal binding site [ion binding]; metal-binding site 405532007796 putative carbohydrate binding site [chemical binding]; other site 405532007797 Cupin domain; Region: Cupin_2; pfam07883 405532007798 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 405532007799 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 405532007800 putative active site; other site 405532007801 catalytic residue [active] 405532007802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532007803 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405532007804 active site 405532007805 metal binding site [ion binding]; metal-binding site 405532007806 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405532007807 active site 405532007808 NTP binding site [chemical binding]; other site 405532007809 metal binding triad [ion binding]; metal-binding site 405532007810 antibiotic binding site [chemical binding]; other site 405532007811 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405532007812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007813 putative substrate translocation pore; other site 405532007814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532007815 putative DNA binding site [nucleotide binding]; other site 405532007816 putative Zn2+ binding site [ion binding]; other site 405532007817 DinB superfamily; Region: DinB_2; pfam12867 405532007818 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405532007819 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405532007820 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405532007821 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 405532007822 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 405532007823 putative catalytic cysteine [active] 405532007824 gamma-glutamyl kinase; Provisional; Region: PRK05429 405532007825 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 405532007826 nucleotide binding site [chemical binding]; other site 405532007827 homotetrameric interface [polypeptide binding]; other site 405532007828 putative phosphate binding site [ion binding]; other site 405532007829 putative allosteric binding site; other site 405532007830 PUA domain; Region: PUA; pfam01472 405532007831 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 405532007832 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 405532007833 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 405532007834 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 405532007835 putative metal binding site [ion binding]; other site 405532007836 putative dimer interface [polypeptide binding]; other site 405532007837 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405532007838 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405532007839 Bacterial transcriptional regulator; Region: IclR; pfam01614 405532007840 S-methylmethionine transporter; Provisional; Region: PRK11387 405532007841 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405532007842 active site 405532007843 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 405532007844 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 405532007845 putative di-iron ligands [ion binding]; other site 405532007846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405532007847 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405532007848 VanW like protein; Region: VanW; pfam04294 405532007849 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 405532007850 dimer interface [polypeptide binding]; other site 405532007851 Alkaline phosphatase homologues; Region: alkPPc; smart00098 405532007852 active site 405532007853 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 405532007854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532007855 salt bridge; other site 405532007856 non-specific DNA binding site [nucleotide binding]; other site 405532007857 sequence-specific DNA binding site [nucleotide binding]; other site 405532007858 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 405532007859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532007860 active site 405532007861 motif I; other site 405532007862 motif II; other site 405532007863 uridine kinase; Provisional; Region: PRK07667 405532007864 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532007865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532007867 Coenzyme A binding pocket [chemical binding]; other site 405532007868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532007869 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405532007870 active site 405532007871 metal binding site [ion binding]; metal-binding site 405532007872 dUTPase; Provisional; Region: PHA03128 405532007873 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 405532007874 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532007875 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405532007876 MoxR-like ATPases [General function prediction only]; Region: COG0714 405532007877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532007878 Walker A motif; other site 405532007879 ATP binding site [chemical binding]; other site 405532007880 Walker B motif; other site 405532007881 arginine finger; other site 405532007882 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405532007883 Protein of unknown function DUF58; Region: DUF58; pfam01882 405532007884 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 405532007885 proline/glycine betaine transporter; Provisional; Region: PRK10642 405532007886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532007887 putative substrate translocation pore; other site 405532007888 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405532007889 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532007890 active site 405532007891 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405532007892 active site 405532007893 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532007894 active site 405532007895 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 405532007896 Ligand binding site; other site 405532007897 Putative Catalytic site; other site 405532007898 DXD motif; other site 405532007899 active site 405532007900 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532007901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532007902 active site 405532007903 acetylornithine aminotransferase; Provisional; Region: PRK02627 405532007904 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405532007905 inhibitor-cofactor binding pocket; inhibition site 405532007906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532007907 catalytic residue [active] 405532007908 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 405532007909 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405532007910 heme binding pocket [chemical binding]; other site 405532007911 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 405532007912 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405532007913 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405532007914 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 405532007915 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405532007916 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 405532007917 active site 405532007918 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 405532007919 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532007920 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532007921 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 405532007922 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405532007923 Protein of unknown function DUF58; Region: DUF58; pfam01882 405532007924 MoxR-like ATPases [General function prediction only]; Region: COG0714 405532007925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532007926 Walker A motif; other site 405532007927 ATP binding site [chemical binding]; other site 405532007928 Walker B motif; other site 405532007929 arginine finger; other site 405532007930 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 405532007931 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 405532007932 LXG domain of WXG superfamily; Region: LXG; pfam04740 405532007933 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 405532007934 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 405532007935 HTH-like domain; Region: HTH_21; pfam13276 405532007936 Integrase core domain; Region: rve; pfam00665 405532007937 Integrase core domain; Region: rve_3; pfam13683 405532007938 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532007939 Winged helix-turn helix; Region: HTH_29; pfam13551 405532007940 Uncharacterized conserved protein [Function unknown]; Region: COG1359 405532007941 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405532007942 dimer interface [polypeptide binding]; other site 405532007943 FMN binding site [chemical binding]; other site 405532007944 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532007945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532007946 putative DNA binding site [nucleotide binding]; other site 405532007947 putative Zn2+ binding site [ion binding]; other site 405532007948 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 405532007949 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 405532007950 G1 box; other site 405532007951 putative GEF interaction site [polypeptide binding]; other site 405532007952 GTP/Mg2+ binding site [chemical binding]; other site 405532007953 Switch I region; other site 405532007954 G2 box; other site 405532007955 G3 box; other site 405532007956 Switch II region; other site 405532007957 G4 box; other site 405532007958 G5 box; other site 405532007959 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 405532007960 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 405532007961 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 405532007962 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405532007963 nudix motif; other site 405532007964 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 405532007965 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 405532007966 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 405532007967 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405532007968 putative NAD(P) binding site [chemical binding]; other site 405532007969 active site 405532007970 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532007971 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532007972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532007973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405532007974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532007975 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 405532007976 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405532007977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532007978 Coenzyme A binding pocket [chemical binding]; other site 405532007979 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 405532007980 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 405532007981 nudix motif; other site 405532007982 EamA-like transporter family; Region: EamA; pfam00892 405532007983 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405532007984 EamA-like transporter family; Region: EamA; pfam00892 405532007985 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405532007986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532007987 DNA-binding site [nucleotide binding]; DNA binding site 405532007988 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532007989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532007990 homodimer interface [polypeptide binding]; other site 405532007991 catalytic residue [active] 405532007992 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532007993 Cupin domain; Region: Cupin_2; pfam07883 405532007994 hypothetical protein; Validated; Region: PRK00124 405532007995 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 405532007996 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405532007997 uridine kinase; Validated; Region: PRK06696 405532007998 AAA domain; Region: AAA_18; pfam13238 405532007999 active site 405532008000 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 405532008001 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532008002 active site 405532008003 metal binding site [ion binding]; metal-binding site 405532008004 Phosphotransferase enzyme family; Region: APH; pfam01636 405532008005 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405532008006 active site 405532008007 ATP binding site [chemical binding]; other site 405532008008 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 405532008009 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405532008010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532008011 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532008012 Coenzyme A binding pocket [chemical binding]; other site 405532008013 Lysine riboswitch 405532008014 lysine transporter; Provisional; Region: PRK10836 405532008015 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 405532008016 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 405532008017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532008018 S-adenosylmethionine binding site [chemical binding]; other site 405532008019 Cache domain; Region: Cache_2; cl07034 405532008020 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405532008021 putative active site [active] 405532008022 nucleotide binding site [chemical binding]; other site 405532008023 nudix motif; other site 405532008024 putative metal binding site [ion binding]; other site 405532008025 Cephalosporin hydroxylase; Region: CmcI; pfam04989 405532008026 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405532008027 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405532008028 Catalytic site [active] 405532008029 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405532008030 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532008031 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532008032 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532008033 NAD-dependent deacetylase; Provisional; Region: PRK00481 405532008034 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 405532008035 NAD+ binding site [chemical binding]; other site 405532008036 substrate binding site [chemical binding]; other site 405532008037 Zn binding site [ion binding]; other site 405532008038 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 405532008039 putative substrate binding pocket [chemical binding]; other site 405532008040 AC domain interface; other site 405532008041 catalytic triad [active] 405532008042 AB domain interface; other site 405532008043 interchain disulfide; other site 405532008044 Predicted membrane protein [Function unknown]; Region: COG3817 405532008045 Protein of unknown function (DUF979); Region: DUF979; pfam06166 405532008046 Protein of unknown function (DUF969); Region: DUF969; pfam06149 405532008047 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 405532008048 putative active site [active] 405532008049 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 405532008050 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 405532008051 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 405532008052 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405532008053 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405532008054 Bacterial transcriptional regulator; Region: IclR; pfam01614 405532008055 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405532008056 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405532008057 Catalytic site [active] 405532008058 CutC family; Region: CutC; cl01218 405532008059 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532008060 dimerization interface [polypeptide binding]; other site 405532008061 putative DNA binding site [nucleotide binding]; other site 405532008062 putative Zn2+ binding site [ion binding]; other site 405532008063 DinB superfamily; Region: DinB_2; pfam12867 405532008064 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405532008065 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405532008066 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 405532008067 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405532008068 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405532008069 putative active site [active] 405532008070 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532008071 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532008072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 405532008073 Nucleoside recognition; Region: Gate; pfam07670 405532008074 Phosphotransferase enzyme family; Region: APH; pfam01636 405532008075 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 405532008076 putative active site [active] 405532008077 putative substrate binding site [chemical binding]; other site 405532008078 ATP binding site [chemical binding]; other site 405532008079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532008080 Coenzyme A binding pocket [chemical binding]; other site 405532008081 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 405532008082 Uncharacterized conserved protein [Function unknown]; Region: COG1633 405532008083 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 405532008084 dinuclear metal binding motif [ion binding]; other site 405532008085 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532008086 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532008087 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405532008088 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405532008089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532008090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532008091 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405532008092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405532008093 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405532008094 phosphoenolpyruvate synthase; Validated; Region: PRK06241 405532008095 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 405532008096 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405532008097 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532008098 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 405532008099 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 405532008100 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405532008101 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 405532008102 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405532008103 NAD binding site [chemical binding]; other site 405532008104 catalytic Zn binding site [ion binding]; other site 405532008105 structural Zn binding site [ion binding]; other site 405532008106 aspartate ammonia-lyase; Provisional; Region: PRK14515 405532008107 Aspartase; Region: Aspartase; cd01357 405532008108 active sites [active] 405532008109 tetramer interface [polypeptide binding]; other site 405532008110 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 405532008111 active site 405532008112 homodimer interface [polypeptide binding]; other site 405532008113 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532008114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532008115 non-specific DNA binding site [nucleotide binding]; other site 405532008116 salt bridge; other site 405532008117 sequence-specific DNA binding site [nucleotide binding]; other site 405532008118 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405532008119 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405532008120 Spore germination protein; Region: Spore_permease; pfam03845 405532008121 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405532008122 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405532008123 PAS fold; Region: PAS_4; pfam08448 405532008124 PAS domain S-box; Region: sensory_box; TIGR00229 405532008125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532008126 putative active site [active] 405532008127 heme pocket [chemical binding]; other site 405532008128 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405532008129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532008130 putative active site [active] 405532008131 heme pocket [chemical binding]; other site 405532008132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532008133 dimer interface [polypeptide binding]; other site 405532008134 phosphorylation site [posttranslational modification] 405532008135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532008136 ATP binding site [chemical binding]; other site 405532008137 Mg2+ binding site [ion binding]; other site 405532008138 G-X-G motif; other site 405532008139 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405532008140 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405532008141 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405532008142 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405532008143 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 405532008144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532008145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532008146 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405532008147 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405532008148 GIY-YIG motif/motif A; other site 405532008149 active site 405532008150 catalytic site [active] 405532008151 putative DNA binding site [nucleotide binding]; other site 405532008152 metal binding site [ion binding]; metal-binding site 405532008153 amino acid transporter; Region: 2A0306; TIGR00909 405532008154 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405532008155 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 405532008156 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 405532008157 DoxX-like family; Region: DoxX_2; pfam13564 405532008158 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 405532008159 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405532008160 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 405532008161 putative NAD(P) binding site [chemical binding]; other site 405532008162 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 405532008163 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405532008164 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405532008165 Spore germination protein; Region: Spore_permease; pfam03845 405532008166 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405532008167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532008168 Response regulator receiver domain; Region: Response_reg; pfam00072 405532008169 active site 405532008170 phosphorylation site [posttranslational modification] 405532008171 intermolecular recognition site; other site 405532008172 dimerization interface [polypeptide binding]; other site 405532008173 YcbB domain; Region: YcbB; pfam08664 405532008174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532008175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532008176 ATP binding site [chemical binding]; other site 405532008177 Mg2+ binding site [ion binding]; other site 405532008178 G-X-G motif; other site 405532008179 glutaminase; Reviewed; Region: PRK12357 405532008180 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405532008181 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405532008182 amino acid carrier protein; Region: agcS; TIGR00835 405532008183 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 405532008184 transmembrane helices; other site 405532008185 Cytochrome P450; Region: p450; cl12078 405532008186 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532008187 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532008188 Erythromycin esterase; Region: Erythro_esteras; pfam05139 405532008189 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405532008190 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 405532008191 putative active site [active] 405532008192 putative metal binding site [ion binding]; other site 405532008193 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405532008194 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532008195 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405532008196 TAP-like protein; Region: Abhydrolase_4; pfam08386 405532008197 Isochorismatase family; Region: Isochorismatase; pfam00857 405532008198 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 405532008199 catalytic triad [active] 405532008200 dimer interface [polypeptide binding]; other site 405532008201 conserved cis-peptide bond; other site 405532008202 Isochorismatase family; Region: Isochorismatase; pfam00857 405532008203 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 405532008204 catalytic triad [active] 405532008205 dimer interface [polypeptide binding]; other site 405532008206 conserved cis-peptide bond; other site 405532008207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 405532008208 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 405532008209 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 405532008210 active site 405532008211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405532008212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532008213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532008214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532008215 dimerization interface [polypeptide binding]; other site 405532008216 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 405532008217 Cl binding site [ion binding]; other site 405532008218 oligomer interface [polypeptide binding]; other site 405532008219 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 405532008220 plasmid segregation protein ParM; Provisional; Region: PRK13917 405532008221 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405532008222 Mg binding site [ion binding]; other site 405532008223 nucleotide binding site [chemical binding]; other site 405532008224 putative protofilament interface [polypeptide binding]; other site 405532008225 Heat induced stress protein YflT; Region: YflT; pfam11181 405532008226 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532008227 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405532008228 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405532008229 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405532008230 TspO/MBR family; Region: TspO_MBR; pfam03073 405532008231 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 405532008232 DNA photolyase; Region: DNA_photolyase; pfam00875 405532008233 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 405532008234 NmrA-like family; Region: NmrA; pfam05368 405532008235 NADP binding site [chemical binding]; other site 405532008236 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532008237 MarR family; Region: MarR_2; pfam12802 405532008238 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 405532008239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532008240 dimerization interface [polypeptide binding]; other site 405532008241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532008242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532008243 dimer interface [polypeptide binding]; other site 405532008244 phosphorylation site [posttranslational modification] 405532008245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532008246 ATP binding site [chemical binding]; other site 405532008247 Mg2+ binding site [ion binding]; other site 405532008248 G-X-G motif; other site 405532008249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532008250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532008251 active site 405532008252 phosphorylation site [posttranslational modification] 405532008253 intermolecular recognition site; other site 405532008254 dimerization interface [polypeptide binding]; other site 405532008255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532008256 DNA binding site [nucleotide binding] 405532008257 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532008258 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405532008259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532008260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532008261 putative substrate translocation pore; other site 405532008262 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405532008263 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405532008264 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 405532008265 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 405532008266 Carbonic anhydrase; Region: Pro_CA; pfam00484 405532008267 zinc binding site [ion binding]; other site 405532008268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 405532008269 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 405532008270 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 405532008271 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405532008272 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 405532008273 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405532008274 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405532008275 NodB motif; other site 405532008276 active site 405532008277 catalytic site [active] 405532008278 Zn binding site [ion binding]; other site 405532008279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532008280 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532008281 Coenzyme A binding pocket [chemical binding]; other site 405532008282 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 405532008283 UbiA prenyltransferase family; Region: UbiA; pfam01040 405532008284 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405532008285 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405532008286 active site 405532008287 ATP binding site [chemical binding]; other site 405532008288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405532008289 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532008290 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 405532008291 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405532008292 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 405532008293 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 405532008294 arsenical-resistance protein; Region: acr3; TIGR00832 405532008295 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532008296 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 405532008297 putative metal binding site [ion binding]; other site 405532008298 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532008299 dimerization interface [polypeptide binding]; other site 405532008300 putative DNA binding site [nucleotide binding]; other site 405532008301 putative Zn2+ binding site [ion binding]; other site 405532008302 DinB superfamily; Region: DinB_2; pfam12867 405532008303 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 405532008304 RibD C-terminal domain; Region: RibD_C; cl17279 405532008305 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405532008306 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 405532008307 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 405532008308 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405532008309 putative NAD(P) binding site [chemical binding]; other site 405532008310 active site 405532008311 putative substrate binding site [chemical binding]; other site 405532008312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532008313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532008314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532008315 short chain dehydrogenase; Provisional; Region: PRK12746 405532008316 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 405532008317 NADP binding site [chemical binding]; other site 405532008318 homodimer interface [polypeptide binding]; other site 405532008319 active site 405532008320 substrate binding site [chemical binding]; other site 405532008321 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 405532008322 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532008323 putative DNA binding site [nucleotide binding]; other site 405532008324 putative Zn2+ binding site [ion binding]; other site 405532008325 AsnC family; Region: AsnC_trans_reg; pfam01037 405532008326 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 405532008327 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405532008328 metal binding site [ion binding]; metal-binding site 405532008329 AAA domain; Region: AAA_11; pfam13086 405532008330 Part of AAA domain; Region: AAA_19; pfam13245 405532008331 Erp protein C-terminus; Region: Erp_C; pfam06780 405532008332 AAA domain; Region: AAA_30; pfam13604 405532008333 AAA domain; Region: AAA_12; pfam13087 405532008334 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405532008335 putative active site [active] 405532008336 catalytic site [active] 405532008337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532008338 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405532008339 active site 405532008340 metal binding site [ion binding]; metal-binding site 405532008341 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 405532008342 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 405532008343 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532008344 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532008345 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532008346 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532008347 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405532008348 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 405532008349 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532008350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532008351 non-specific DNA binding site [nucleotide binding]; other site 405532008352 salt bridge; other site 405532008353 sequence-specific DNA binding site [nucleotide binding]; other site 405532008354 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405532008355 amidase catalytic site [active] 405532008356 Zn binding residues [ion binding]; other site 405532008357 substrate binding site [chemical binding]; other site 405532008358 S-layer homology domain; Region: SLH; pfam00395 405532008359 S-layer homology domain; Region: SLH; pfam00395 405532008360 S-layer homology domain; Region: SLH; pfam00395 405532008361 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532008362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532008363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532008364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532008365 dimerization interface [polypeptide binding]; other site 405532008366 EamA-like transporter family; Region: EamA; pfam00892 405532008367 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405532008368 EamA-like transporter family; Region: EamA; pfam00892 405532008369 putative monooxygenase; Provisional; Region: PRK11118 405532008370 DoxX-like family; Region: DoxX_2; pfam13564 405532008371 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405532008372 MarR family; Region: MarR_2; pfam12802 405532008373 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 405532008374 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405532008375 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 405532008376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532008377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532008378 active site 405532008379 phosphorylation site [posttranslational modification] 405532008380 intermolecular recognition site; other site 405532008381 dimerization interface [polypeptide binding]; other site 405532008382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532008383 DNA binding site [nucleotide binding] 405532008384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532008385 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532008386 dimerization interface [polypeptide binding]; other site 405532008387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532008388 dimer interface [polypeptide binding]; other site 405532008389 phosphorylation site [posttranslational modification] 405532008390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532008391 ATP binding site [chemical binding]; other site 405532008392 G-X-G motif; other site 405532008393 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 405532008394 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405532008395 CAAX protease self-immunity; Region: Abi; pfam02517 405532008396 Erythromycin esterase; Region: Erythro_esteras; pfam05139 405532008397 Putative sensor; Region: Sensor; pfam13796 405532008398 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405532008399 Histidine kinase; Region: HisKA_3; pfam07730 405532008400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532008401 ATP binding site [chemical binding]; other site 405532008402 Mg2+ binding site [ion binding]; other site 405532008403 G-X-G motif; other site 405532008404 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405532008405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532008406 active site 405532008407 phosphorylation site [posttranslational modification] 405532008408 intermolecular recognition site; other site 405532008409 dimerization interface [polypeptide binding]; other site 405532008410 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405532008411 DNA binding residues [nucleotide binding] 405532008412 dimerization interface [polypeptide binding]; other site 405532008413 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405532008414 putative metal binding site [ion binding]; other site 405532008415 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405532008416 Cytochrome P450; Region: p450; pfam00067 405532008417 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 405532008418 Flavodoxin; Region: Flavodoxin_1; pfam00258 405532008419 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 405532008420 FAD binding pocket [chemical binding]; other site 405532008421 FAD binding motif [chemical binding]; other site 405532008422 catalytic residues [active] 405532008423 NAD binding pocket [chemical binding]; other site 405532008424 phosphate binding motif [ion binding]; other site 405532008425 beta-alpha-beta structure motif; other site 405532008426 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405532008427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532008428 putative substrate translocation pore; other site 405532008429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532008430 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 405532008431 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405532008432 D-cysteine desulfhydrase; Validated; Region: PRK03910 405532008433 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 405532008434 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532008435 catalytic residue [active] 405532008436 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405532008437 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532008438 active site 405532008439 metal binding site [ion binding]; metal-binding site 405532008440 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 405532008441 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 405532008442 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 405532008443 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 405532008444 Leucine carboxyl methyltransferase; Region: LCM; cl01306 405532008445 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 405532008446 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 405532008447 hypothetical protein; Provisional; Region: PRK06762 405532008448 AAA domain; Region: AAA_33; pfam13671 405532008449 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 405532008450 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 405532008451 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532008452 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532008453 Walker A/P-loop; other site 405532008454 ATP binding site [chemical binding]; other site 405532008455 Q-loop/lid; other site 405532008456 ABC transporter signature motif; other site 405532008457 Walker B; other site 405532008458 D-loop; other site 405532008459 H-loop/switch region; other site 405532008460 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405532008461 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405532008462 FtsX-like permease family; Region: FtsX; pfam02687 405532008463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532008464 dimerization interface [polypeptide binding]; other site 405532008465 putative DNA binding site [nucleotide binding]; other site 405532008466 Predicted transcriptional regulator [Transcription]; Region: COG2345 405532008467 putative Zn2+ binding site [ion binding]; other site 405532008468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532008469 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532008470 putative substrate translocation pore; other site 405532008471 DinB superfamily; Region: DinB_2; pfam12867 405532008472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532008473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532008474 dimerization interface [polypeptide binding]; other site 405532008475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532008476 dimer interface [polypeptide binding]; other site 405532008477 phosphorylation site [posttranslational modification] 405532008478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532008479 ATP binding site [chemical binding]; other site 405532008480 Mg2+ binding site [ion binding]; other site 405532008481 G-X-G motif; other site 405532008482 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532008483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532008484 active site 405532008485 phosphorylation site [posttranslational modification] 405532008486 intermolecular recognition site; other site 405532008487 dimerization interface [polypeptide binding]; other site 405532008488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532008489 DNA binding site [nucleotide binding] 405532008490 Predicted membrane protein [Function unknown]; Region: COG2364 405532008491 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532008492 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405532008493 MarR family; Region: MarR; pfam01047 405532008494 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532008495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532008496 Coenzyme A binding pocket [chemical binding]; other site 405532008497 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 405532008498 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532008499 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532008500 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532008501 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 405532008502 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 405532008503 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 405532008504 Uncharacterized conserved protein [Function unknown]; Region: COG4198 405532008505 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 405532008506 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 405532008507 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 405532008508 putative ligand binding site [chemical binding]; other site 405532008509 putative NAD binding site [chemical binding]; other site 405532008510 putative catalytic site [active] 405532008511 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 405532008512 L-serine binding site [chemical binding]; other site 405532008513 ACT domain interface; other site 405532008514 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 405532008515 homodimer interface [polypeptide binding]; other site 405532008516 substrate-cofactor binding pocket; other site 405532008517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532008518 catalytic residue [active] 405532008519 Uncharacterized conserved protein [Function unknown]; Region: COG2155 405532008520 Penicillin amidase; Region: Penicil_amidase; pfam01804 405532008521 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 405532008522 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 405532008523 active site 405532008524 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405532008525 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405532008526 substrate binding site [chemical binding]; other site 405532008527 amidase catalytic site [active] 405532008528 Zn binding residues [ion binding]; other site 405532008529 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532008530 S-layer homology domain; Region: SLH; pfam00395 405532008531 S-layer homology domain; Region: SLH; pfam00395 405532008532 S-layer homology domain; Region: SLH; pfam00395 405532008533 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 405532008534 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405532008535 A new structural DNA glycosylase; Region: AlkD_like; cd06561 405532008536 active site 405532008537 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 405532008538 Syd protein (SUKH-2); Region: Syd; pfam07348 405532008539 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 405532008540 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 405532008541 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405532008542 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 405532008543 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 405532008544 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405532008545 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405532008546 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 405532008547 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 405532008548 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 405532008549 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405532008550 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 405532008551 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 405532008552 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405532008553 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405532008554 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 405532008555 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 405532008556 putative active site [active] 405532008557 putative metal binding site [ion binding]; other site 405532008558 NETI protein; Region: NETI; pfam14044 405532008559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532008560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532008561 putative substrate translocation pore; other site 405532008562 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532008563 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405532008564 TAP-like protein; Region: Abhydrolase_4; pfam08386 405532008565 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532008566 MarR family; Region: MarR_2; pfam12802 405532008567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532008568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532008569 putative substrate translocation pore; other site 405532008570 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532008571 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532008572 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 405532008573 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 405532008574 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405532008575 SWIM zinc finger; Region: SWIM; pfam04434 405532008576 YwiC-like protein; Region: YwiC; pfam14256 405532008577 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 405532008578 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405532008579 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405532008580 Walker A/P-loop; other site 405532008581 ATP binding site [chemical binding]; other site 405532008582 Q-loop/lid; other site 405532008583 ABC transporter signature motif; other site 405532008584 Walker B; other site 405532008585 D-loop; other site 405532008586 H-loop/switch region; other site 405532008587 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405532008588 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 405532008589 Walker A/P-loop; other site 405532008590 ATP binding site [chemical binding]; other site 405532008591 Q-loop/lid; other site 405532008592 ABC transporter signature motif; other site 405532008593 Walker B; other site 405532008594 D-loop; other site 405532008595 H-loop/switch region; other site 405532008596 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405532008597 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 405532008598 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 405532008599 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 405532008600 Predicted membrane protein [Function unknown]; Region: COG1288 405532008601 Endonuclease I; Region: Endonuclease_1; pfam04231 405532008602 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405532008603 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 405532008604 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532008605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532008606 non-specific DNA binding site [nucleotide binding]; other site 405532008607 salt bridge; other site 405532008608 sequence-specific DNA binding site [nucleotide binding]; other site 405532008609 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 405532008610 putative deacylase active site [active] 405532008611 histidyl-tRNA synthetase; Provisional; Region: PRK12420 405532008612 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405532008613 dimer interface [polypeptide binding]; other site 405532008614 motif 1; other site 405532008615 active site 405532008616 motif 2; other site 405532008617 motif 3; other site 405532008618 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405532008619 anticodon binding site; other site 405532008620 Predicted transcriptional regulators [Transcription]; Region: COG1733 405532008621 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405532008622 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 405532008623 dimer interface [polypeptide binding]; other site 405532008624 FMN binding site [chemical binding]; other site 405532008625 pyruvate kinase; Validated; Region: PRK06739 405532008626 active site 405532008627 domain interfaces; other site 405532008628 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 405532008629 classical (c) SDRs; Region: SDR_c; cd05233 405532008630 NAD(P) binding site [chemical binding]; other site 405532008631 active site 405532008632 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405532008633 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532008634 Walker A/P-loop; other site 405532008635 ATP binding site [chemical binding]; other site 405532008636 Q-loop/lid; other site 405532008637 ABC transporter signature motif; other site 405532008638 Walker B; other site 405532008639 D-loop; other site 405532008640 H-loop/switch region; other site 405532008641 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 405532008642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532008643 non-specific DNA binding site [nucleotide binding]; other site 405532008644 salt bridge; other site 405532008645 sequence-specific DNA binding site [nucleotide binding]; other site 405532008646 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 405532008647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532008648 motif II; other site 405532008649 Phosphotransferase enzyme family; Region: APH; pfam01636 405532008650 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405532008651 active site 405532008652 ATP binding site [chemical binding]; other site 405532008653 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405532008654 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 405532008655 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 405532008656 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532008657 Coenzyme A binding pocket [chemical binding]; other site 405532008658 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405532008659 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405532008660 nudix motif; other site 405532008661 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405532008662 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405532008663 active site 405532008664 HIGH motif; other site 405532008665 dimer interface [polypeptide binding]; other site 405532008666 KMSKS motif; other site 405532008667 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 405532008668 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 405532008669 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 405532008670 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 405532008671 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405532008672 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405532008673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532008674 Coenzyme A binding pocket [chemical binding]; other site 405532008675 ydaO/yuaA leader 405532008676 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 405532008677 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532008678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532008679 S-adenosylmethionine binding site [chemical binding]; other site 405532008680 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 405532008681 CGNR zinc finger; Region: zf-CGNR; pfam11706 405532008682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532008683 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532008684 putative substrate translocation pore; other site 405532008685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532008686 TPR motif; other site 405532008687 TPR repeat; Region: TPR_11; pfam13414 405532008688 binding surface 405532008689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532008690 binding surface 405532008691 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405532008692 TPR motif; other site 405532008693 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 405532008694 hypothetical protein; Provisional; Region: PRK04164 405532008695 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532008696 ATP synthase I chain; Region: ATP_synt_I; cl09170 405532008697 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405532008698 Domain of unknown function DUF21; Region: DUF21; pfam01595 405532008699 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405532008700 Transporter associated domain; Region: CorC_HlyC; smart01091 405532008701 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 405532008702 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405532008703 DNA binding residues [nucleotide binding] 405532008704 putative dimer interface [polypeptide binding]; other site 405532008705 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 405532008706 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 405532008707 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 405532008708 substrate binding site; other site 405532008709 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 405532008710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532008711 NAD(P) binding site [chemical binding]; other site 405532008712 active site 405532008713 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 405532008714 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532008715 Methyltransferase domain; Region: Methyltransf_12; pfam08242 405532008716 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 405532008717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532008718 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405532008719 NAD(P) binding site [chemical binding]; other site 405532008720 active site 405532008721 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 405532008722 Variant SH3 domain; Region: SH3_2; pfam07653 405532008723 peptide ligand binding site [polypeptide binding]; other site 405532008724 Src Homology 3 domain superfamily; Region: SH3; cl17036 405532008725 peptide ligand binding site [polypeptide binding]; other site 405532008726 EamA-like transporter family; Region: EamA; pfam00892 405532008727 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405532008728 EamA-like transporter family; Region: EamA; pfam00892 405532008729 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 405532008730 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 405532008731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 405532008732 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 405532008733 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 405532008734 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 405532008735 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 405532008736 N- and C-terminal domain interface [polypeptide binding]; other site 405532008737 active site 405532008738 catalytic site [active] 405532008739 metal binding site [ion binding]; metal-binding site 405532008740 carbohydrate binding site [chemical binding]; other site 405532008741 ATP binding site [chemical binding]; other site 405532008742 GntP family permease; Region: GntP_permease; pfam02447 405532008743 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405532008744 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405532008745 active site 405532008746 intersubunit interactions; other site 405532008747 catalytic residue [active] 405532008748 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 405532008749 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405532008750 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 405532008751 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405532008752 TPP-binding site [chemical binding]; other site 405532008753 dimer interface [polypeptide binding]; other site 405532008754 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405532008755 PYR/PP interface [polypeptide binding]; other site 405532008756 dimer interface [polypeptide binding]; other site 405532008757 TPP binding site [chemical binding]; other site 405532008758 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405532008759 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 405532008760 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 405532008761 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 405532008762 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 405532008763 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 405532008764 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405532008765 putative NAD(P) binding site [chemical binding]; other site 405532008766 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405532008767 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405532008768 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405532008769 active site 405532008770 Zn binding site [ion binding]; other site 405532008771 Viral enhancin protein; Region: Enhancin; pfam03272 405532008772 Peptidase M60-like family; Region: M60-like; pfam13402 405532008773 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 405532008774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532008775 dimerization interface [polypeptide binding]; other site 405532008776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532008777 dimer interface [polypeptide binding]; other site 405532008778 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 405532008779 putative CheW interface [polypeptide binding]; other site 405532008780 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 405532008781 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 405532008782 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 405532008783 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 405532008784 catalytic motif [active] 405532008785 Zn binding site [ion binding]; other site 405532008786 RibD C-terminal domain; Region: RibD_C; cl17279 405532008787 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 405532008788 dimerization interface [polypeptide binding]; other site 405532008789 active site 405532008790 Predicted transcriptional regulators [Transcription]; Region: COG1733 405532008791 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405532008792 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405532008793 dimer interface [polypeptide binding]; other site 405532008794 FMN binding site [chemical binding]; other site 405532008795 hypothetical protein; Provisional; Region: PRK02487 405532008796 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 405532008797 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 405532008798 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 405532008799 PhnA protein; Region: PhnA; pfam03831 405532008800 putative transporter; Provisional; Region: PRK11660 405532008801 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 405532008802 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405532008803 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405532008804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532008805 dimerization interface [polypeptide binding]; other site 405532008806 putative DNA binding site [nucleotide binding]; other site 405532008807 putative Zn2+ binding site [ion binding]; other site 405532008808 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405532008809 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 405532008810 IDEAL domain; Region: IDEAL; pfam08858 405532008811 Transcriptional regulator; Region: Rrf2; pfam02082 405532008812 Rrf2 family protein; Region: rrf2_super; TIGR00738 405532008813 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 405532008814 ArsC family; Region: ArsC; pfam03960 405532008815 putative catalytic residues [active] 405532008816 thiol/disulfide switch; other site 405532008817 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405532008818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532008819 DNA-binding site [nucleotide binding]; DNA binding site 405532008820 UTRA domain; Region: UTRA; pfam07702 405532008821 putative oxidoreductase; Provisional; Region: PRK10206 405532008822 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405532008823 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405532008824 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 405532008825 putative hydrophobic ligand binding site [chemical binding]; other site 405532008826 protein interface [polypeptide binding]; other site 405532008827 gate; other site 405532008828 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 405532008829 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 405532008830 putative active site [active] 405532008831 putative catalytic triad [active] 405532008832 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 405532008833 catalytic triad [active] 405532008834 oxyanion hole [active] 405532008835 active site 405532008836 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532008837 Phosphotransferase enzyme family; Region: APH; pfam01636 405532008838 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 405532008839 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405532008840 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405532008841 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 405532008842 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405532008843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532008844 Coenzyme A binding pocket [chemical binding]; other site 405532008845 C factor cell-cell signaling protein; Provisional; Region: PRK09009 405532008846 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 405532008847 NADP binding site [chemical binding]; other site 405532008848 homodimer interface [polypeptide binding]; other site 405532008849 active site 405532008850 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532008851 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532008852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532008853 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532008854 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 405532008855 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405532008856 acyl-activating enzyme (AAE) consensus motif; other site 405532008857 AMP binding site [chemical binding]; other site 405532008858 active site 405532008859 CoA binding site [chemical binding]; other site 405532008860 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405532008861 Predicted transcriptional regulators [Transcription]; Region: COG1733 405532008862 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532008863 dimerization interface [polypeptide binding]; other site 405532008864 putative DNA binding site [nucleotide binding]; other site 405532008865 putative Zn2+ binding site [ion binding]; other site 405532008866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532008867 dimerization interface [polypeptide binding]; other site 405532008868 putative DNA binding site [nucleotide binding]; other site 405532008869 putative Zn2+ binding site [ion binding]; other site 405532008870 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 405532008871 active site 405532008872 Glyco_18 domain; Region: Glyco_18; smart00636 405532008873 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405532008874 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 405532008875 NodB motif; other site 405532008876 putative active site [active] 405532008877 putative catalytic site [active] 405532008878 putative Zn binding site [ion binding]; other site 405532008879 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405532008880 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405532008881 DXD motif; other site 405532008882 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 405532008883 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 405532008884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532008885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532008886 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 405532008887 active site 405532008888 VPS10 domain; Region: VPS10; smart00602 405532008889 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405532008890 HTH domain; Region: HTH_11; pfam08279 405532008891 WYL domain; Region: WYL; pfam13280 405532008892 ABC-2 type transporter; Region: ABC2_membrane; cl17235 405532008893 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405532008894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532008895 Walker A/P-loop; other site 405532008896 ATP binding site [chemical binding]; other site 405532008897 Q-loop/lid; other site 405532008898 ABC transporter signature motif; other site 405532008899 Walker B; other site 405532008900 D-loop; other site 405532008901 H-loop/switch region; other site 405532008902 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 405532008903 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532008904 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405532008905 Integrase core domain; Region: rve; pfam00665 405532008906 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 405532008907 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 405532008908 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 405532008909 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 405532008910 RHS protein; Region: RHS; pfam03527 405532008911 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 405532008912 hydroxylamine reductase; Provisional; Region: PRK12310 405532008913 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405532008914 ACS interaction site; other site 405532008915 CODH interaction site; other site 405532008916 metal cluster binding site [ion binding]; other site 405532008917 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532008918 hypothetical protein; Provisional; Region: PRK06771 405532008919 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532008920 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532008921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 405532008922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 405532008923 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 405532008924 dimer interface [polypeptide binding]; other site 405532008925 ligand binding site [chemical binding]; other site 405532008926 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405532008927 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405532008928 ligand binding site [chemical binding]; other site 405532008929 flexible hinge region; other site 405532008930 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 405532008931 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405532008932 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405532008933 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532008934 putative transport protein YifK; Provisional; Region: PRK10746 405532008935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532008936 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405532008937 putative substrate translocation pore; other site 405532008938 Haemolysin XhlA; Region: XhlA; pfam10779 405532008939 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 405532008940 classical (c) SDRs; Region: SDR_c; cd05233 405532008941 NAD(P) binding site [chemical binding]; other site 405532008942 active site 405532008943 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 405532008944 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 405532008945 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405532008946 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 405532008947 transmembrane helices; other site 405532008948 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532008949 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532008950 Coenzyme A binding pocket [chemical binding]; other site 405532008951 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405532008952 putative ligand binding residues [chemical binding]; other site 405532008953 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 405532008954 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405532008955 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532008956 ABC-ATPase subunit interface; other site 405532008957 dimer interface [polypeptide binding]; other site 405532008958 putative PBP binding regions; other site 405532008959 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405532008960 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532008961 ABC-ATPase subunit interface; other site 405532008962 dimer interface [polypeptide binding]; other site 405532008963 putative PBP binding regions; other site 405532008964 Protein of unknown function (DUF817); Region: DUF817; pfam05675 405532008965 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 405532008966 DinB superfamily; Region: DinB_2; pfam12867 405532008967 DinB family; Region: DinB; cl17821 405532008968 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 405532008969 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 405532008970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532008971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532008972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532008973 dimerization interface [polypeptide binding]; other site 405532008974 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405532008975 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 405532008976 NADP binding site [chemical binding]; other site 405532008977 dimer interface [polypeptide binding]; other site 405532008978 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405532008979 catalytic core [active] 405532008980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532008981 Coenzyme A binding pocket [chemical binding]; other site 405532008982 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 405532008983 MutS domain III; Region: MutS_III; pfam05192 405532008984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532008985 Walker A/P-loop; other site 405532008986 ATP binding site [chemical binding]; other site 405532008987 Q-loop/lid; other site 405532008988 ABC transporter signature motif; other site 405532008989 Walker B; other site 405532008990 D-loop; other site 405532008991 H-loop/switch region; other site 405532008992 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 405532008993 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 405532008994 active site 405532008995 Na/Ca binding site [ion binding]; other site 405532008996 catalytic site [active] 405532008997 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 405532008998 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 405532008999 oligoendopeptidase F; Region: pepF; TIGR00181 405532009000 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 405532009001 active site 405532009002 Zn binding site [ion binding]; other site 405532009003 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 405532009004 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 405532009005 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405532009006 active site 405532009007 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405532009008 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405532009009 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405532009010 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405532009011 DNA binding residues [nucleotide binding] 405532009012 drug binding residues [chemical binding]; other site 405532009013 dimer interface [polypeptide binding]; other site 405532009014 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405532009015 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 405532009016 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 405532009017 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 405532009018 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 405532009019 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 405532009020 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532009021 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532009022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532009023 putative substrate translocation pore; other site 405532009024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532009025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532009026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532009027 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405532009028 putative dimerization interface [polypeptide binding]; other site 405532009029 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 405532009030 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 405532009031 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405532009032 active site 405532009033 catalytic site [active] 405532009034 metal binding site [ion binding]; metal-binding site 405532009035 FAD binding domain; Region: FAD_binding_3; pfam01494 405532009036 hypothetical protein; Provisional; Region: PRK07236 405532009037 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 405532009038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532009039 dimerization interface [polypeptide binding]; other site 405532009040 putative DNA binding site [nucleotide binding]; other site 405532009041 putative Zn2+ binding site [ion binding]; other site 405532009042 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405532009043 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 405532009044 putative NAD(P) binding site [chemical binding]; other site 405532009045 Uncharacterized conserved protein [Function unknown]; Region: COG0397 405532009046 hypothetical protein; Validated; Region: PRK00029 405532009047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532009048 TPR motif; other site 405532009049 binding surface 405532009050 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 405532009051 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405532009052 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 405532009053 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405532009054 FAD binding domain; Region: FAD_binding_4; pfam01565 405532009055 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 405532009056 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532009057 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532009058 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 405532009059 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 405532009060 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 405532009061 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405532009062 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405532009063 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405532009064 active site residue [active] 405532009065 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 405532009066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532009067 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 405532009068 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 405532009069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405532009070 active site 405532009071 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405532009072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532009073 NAD(P) binding site [chemical binding]; other site 405532009074 active site 405532009075 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 405532009076 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 405532009077 NAD binding site [chemical binding]; other site 405532009078 homotetramer interface [polypeptide binding]; other site 405532009079 homodimer interface [polypeptide binding]; other site 405532009080 substrate binding site [chemical binding]; other site 405532009081 active site 405532009082 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405532009083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532009084 TPR motif; other site 405532009085 binding surface 405532009086 Tar ligand binding domain homologue; Region: TarH; pfam02203 405532009087 Cache domain; Region: Cache_1; pfam02743 405532009088 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532009089 dimerization interface [polypeptide binding]; other site 405532009090 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532009091 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532009092 dimer interface [polypeptide binding]; other site 405532009093 putative CheW interface [polypeptide binding]; other site 405532009094 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 405532009095 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 405532009096 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 405532009097 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 405532009098 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 405532009099 gp58-like protein; Region: Gp58; pfam07902 405532009100 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405532009101 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 405532009102 Baseplate J-like protein; Region: Baseplate_J; pfam04865 405532009103 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405532009104 Peptidase family M23; Region: Peptidase_M23; pfam01551 405532009105 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 405532009106 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405532009107 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405532009108 catalytic residue [active] 405532009109 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405532009110 amidase catalytic site [active] 405532009111 Zn binding residues [ion binding]; other site 405532009112 substrate binding site [chemical binding]; other site 405532009113 Staphylococcal nuclease homologues; Region: SNc; smart00318 405532009114 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 405532009115 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 405532009116 protein-splicing catalytic site; other site 405532009117 thioester formation/cholesterol transfer; other site 405532009118 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 405532009119 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; cl10351 405532009120 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 405532009121 active site 405532009122 catalytic residues [active] 405532009123 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 405532009124 ATP synthase subunit C; Region: ATP-synt_C; cl00466 405532009125 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 405532009126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532009127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532009128 dimer interface [polypeptide binding]; other site 405532009129 phosphorylation site [posttranslational modification] 405532009130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532009131 ATP binding site [chemical binding]; other site 405532009132 Mg2+ binding site [ion binding]; other site 405532009133 G-X-G motif; other site 405532009134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532009135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532009136 dimer interface [polypeptide binding]; other site 405532009137 phosphorylation site [posttranslational modification] 405532009138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532009139 ATP binding site [chemical binding]; other site 405532009140 Mg2+ binding site [ion binding]; other site 405532009141 G-X-G motif; other site 405532009142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532009143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532009144 active site 405532009145 phosphorylation site [posttranslational modification] 405532009146 intermolecular recognition site; other site 405532009147 dimerization interface [polypeptide binding]; other site 405532009148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532009149 DNA binding site [nucleotide binding] 405532009150 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 405532009151 3D domain; Region: 3D; cl01439 405532009152 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 405532009153 Phage lysis protein, holin; Region: Phage_holin; cl04675 405532009154 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405532009155 dimer interface [polypeptide binding]; other site 405532009156 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405532009157 ssDNA binding site [nucleotide binding]; other site 405532009158 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405532009159 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 405532009160 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405532009161 amidase catalytic site [active] 405532009162 Zn binding residues [ion binding]; other site 405532009163 substrate binding site [chemical binding]; other site 405532009164 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 405532009165 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532009166 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 405532009167 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 405532009168 YolD-like protein; Region: YolD; pfam08863 405532009169 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 405532009170 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 405532009171 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 405532009172 FIC domain binding interface [polypeptide binding]; other site 405532009173 PAS domain S-box; Region: sensory_box; TIGR00229 405532009174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532009175 putative active site [active] 405532009176 heme pocket [chemical binding]; other site 405532009177 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405532009178 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405532009179 metal binding site [ion binding]; metal-binding site 405532009180 active site 405532009181 I-site; other site 405532009182 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405532009183 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405532009184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532009185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532009186 ABC transporter; Region: ABC_tran; pfam00005 405532009187 TQXA domain; Region: TQXA_dom; TIGR03934 405532009188 Cna protein B-type domain; Region: Cna_B; pfam05738 405532009189 Cna protein B-type domain; Region: Cna_B; pfam05738 405532009190 Cna protein B-type domain; Region: Cna_B; pfam05738 405532009191 Cna protein B-type domain; Region: Cna_B; pfam05738 405532009192 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405532009193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532009194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532009195 dimer interface [polypeptide binding]; other site 405532009196 phosphorylation site [posttranslational modification] 405532009197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532009198 ATP binding site [chemical binding]; other site 405532009199 Mg2+ binding site [ion binding]; other site 405532009200 G-X-G motif; other site 405532009201 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 405532009202 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405532009203 FOG: PKD repeat [General function prediction only]; Region: COG3291 405532009204 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 405532009205 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405532009206 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 405532009207 MgtC family; Region: MgtC; pfam02308 405532009208 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532009209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532009210 Coenzyme A binding pocket [chemical binding]; other site 405532009211 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405532009212 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 405532009213 putative metal binding site [ion binding]; other site 405532009214 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405532009215 active site 405532009216 VanW like protein; Region: VanW; pfam04294 405532009217 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 405532009218 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 405532009219 exonuclease; Provisional; Region: PRK06722 405532009220 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 405532009221 active site 405532009222 catalytic site [active] 405532009223 substrate binding site [chemical binding]; other site 405532009224 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405532009225 DNA-binding site [nucleotide binding]; DNA binding site 405532009226 RNA-binding motif; other site 405532009227 flavodoxin; Provisional; Region: PRK06703 405532009228 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 405532009229 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405532009230 nudix motif; other site 405532009231 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 405532009232 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 405532009233 trimer interface [polypeptide binding]; other site 405532009234 active site 405532009235 substrate binding site [chemical binding]; other site 405532009236 CoA binding site [chemical binding]; other site 405532009237 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009238 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009239 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009240 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009241 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009242 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009243 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009244 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009245 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009246 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009247 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009248 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009249 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009250 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532009251 short chain dehydrogenase; Provisional; Region: PRK06924 405532009252 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 405532009253 NADP binding site [chemical binding]; other site 405532009254 homodimer interface [polypeptide binding]; other site 405532009255 active site 405532009256 Predicted acetyltransferase [General function prediction only]; Region: COG3393 405532009257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532009258 Coenzyme A binding pocket [chemical binding]; other site 405532009259 argininosuccinate lyase; Provisional; Region: PRK06705 405532009260 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 405532009261 active sites [active] 405532009262 tetramer interface [polypeptide binding]; other site 405532009263 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532009264 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532009265 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405532009266 active site 405532009267 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405532009268 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 405532009269 Na binding site [ion binding]; other site 405532009270 Protein of unknown function (DUF997); Region: DUF997; pfam06196 405532009271 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 405532009272 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405532009273 NAD(P) binding site [chemical binding]; other site 405532009274 catalytic residues [active] 405532009275 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 405532009276 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405532009277 NAD(P) binding site [chemical binding]; other site 405532009278 homotetramer interface [polypeptide binding]; other site 405532009279 homodimer interface [polypeptide binding]; other site 405532009280 active site 405532009281 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 405532009282 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 405532009283 Divergent PAP2 family; Region: DUF212; pfam02681 405532009284 Predicted permeases [General function prediction only]; Region: RarD; COG2962 405532009285 EamA-like transporter family; Region: EamA; pfam00892 405532009286 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 405532009287 antiporter inner membrane protein; Provisional; Region: PRK11670 405532009288 Domain of unknown function DUF59; Region: DUF59; pfam01883 405532009289 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 405532009290 Walker A motif; other site 405532009291 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405532009292 MoaE interaction surface [polypeptide binding]; other site 405532009293 MoeB interaction surface [polypeptide binding]; other site 405532009294 thiocarboxylated glycine; other site 405532009295 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405532009296 MoaE homodimer interface [polypeptide binding]; other site 405532009297 MoaD interaction [polypeptide binding]; other site 405532009298 active site residues [active] 405532009299 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405532009300 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405532009301 dimer interface [polypeptide binding]; other site 405532009302 putative functional site; other site 405532009303 putative MPT binding site; other site 405532009304 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405532009305 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405532009306 ATP binding site [chemical binding]; other site 405532009307 substrate interface [chemical binding]; other site 405532009308 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405532009309 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 405532009310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532009311 FeS/SAM binding site; other site 405532009312 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405532009313 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 405532009314 Uncharacterized conserved protein [Function unknown]; Region: COG5609 405532009315 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405532009316 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 405532009317 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405532009318 catalytic loop [active] 405532009319 iron binding site [ion binding]; other site 405532009320 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 405532009321 4Fe-4S binding domain; Region: Fer4; pfam00037 405532009322 4Fe-4S binding domain; Region: Fer4; pfam00037 405532009323 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 405532009324 [4Fe-4S] binding site [ion binding]; other site 405532009325 molybdopterin cofactor binding site; other site 405532009326 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 405532009327 molybdopterin cofactor binding site; other site 405532009328 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405532009329 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 405532009330 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405532009331 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405532009332 amino acid transporter; Region: 2A0306; TIGR00909 405532009333 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405532009334 Tubulin like; Region: Tubulin_2; pfam13809 405532009335 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 405532009336 metal ion-dependent adhesion site (MIDAS); other site 405532009337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532009338 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405532009339 active site 405532009340 metal binding site [ion binding]; metal-binding site 405532009341 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405532009342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532009343 S-adenosylmethionine binding site [chemical binding]; other site 405532009344 O-methyltransferase; Region: Methyltransf_2; pfam00891 405532009345 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532009346 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532009347 peptide binding site [polypeptide binding]; other site 405532009348 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532009349 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532009350 peptide binding site [polypeptide binding]; other site 405532009351 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405532009352 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405532009353 peptide binding site [polypeptide binding]; other site 405532009354 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 405532009355 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405532009356 Transcriptional regulator [Transcription]; Region: LytR; COG1316 405532009357 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 405532009358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532009359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532009360 DNA binding residues [nucleotide binding] 405532009361 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405532009362 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532009363 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532009364 Walker A/P-loop; other site 405532009365 ATP binding site [chemical binding]; other site 405532009366 Q-loop/lid; other site 405532009367 ABC transporter signature motif; other site 405532009368 Walker B; other site 405532009369 D-loop; other site 405532009370 H-loop/switch region; other site 405532009371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532009372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532009373 putative oxidoreductase; Provisional; Region: PRK11579 405532009374 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405532009375 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405532009376 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 405532009377 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405532009378 CAP-like domain; other site 405532009379 active site 405532009380 primary dimer interface [polypeptide binding]; other site 405532009381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532009382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532009383 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532009384 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405532009385 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 405532009386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532009387 ATP binding site [chemical binding]; other site 405532009388 Mg2+ binding site [ion binding]; other site 405532009389 G-X-G motif; other site 405532009390 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405532009391 anchoring element; other site 405532009392 dimer interface [polypeptide binding]; other site 405532009393 ATP binding site [chemical binding]; other site 405532009394 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405532009395 active site 405532009396 putative metal-binding site [ion binding]; other site 405532009397 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405532009398 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 405532009399 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405532009400 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405532009401 protein binding site [polypeptide binding]; other site 405532009402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532009403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532009404 active site 405532009405 phosphorylation site [posttranslational modification] 405532009406 intermolecular recognition site; other site 405532009407 dimerization interface [polypeptide binding]; other site 405532009408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532009409 DNA binding site [nucleotide binding] 405532009410 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 405532009411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532009412 FeS/SAM binding site; other site 405532009413 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 405532009414 Class III ribonucleotide reductase; Region: RNR_III; cd01675 405532009415 effector binding site; other site 405532009416 active site 405532009417 Zn binding site [ion binding]; other site 405532009418 glycine loop; other site 405532009419 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 405532009420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 405532009421 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405532009422 active site 405532009423 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 405532009424 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405532009425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405532009426 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 405532009427 active site 405532009428 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 405532009429 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 405532009430 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 405532009431 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405532009432 active site 405532009433 catalytic site [active] 405532009434 substrate binding site [chemical binding]; other site 405532009435 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405532009436 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405532009437 catalytic residues [active] 405532009438 YmzC-like protein; Region: YmzC; pfam14157 405532009439 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405532009440 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532009441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532009442 Walker A/P-loop; other site 405532009443 ATP binding site [chemical binding]; other site 405532009444 Q-loop/lid; other site 405532009445 ABC transporter signature motif; other site 405532009446 Walker B; other site 405532009447 D-loop; other site 405532009448 H-loop/switch region; other site 405532009449 aconitate hydratase; Validated; Region: PRK09277 405532009450 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 405532009451 substrate binding site [chemical binding]; other site 405532009452 ligand binding site [chemical binding]; other site 405532009453 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 405532009454 substrate binding site [chemical binding]; other site 405532009455 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 405532009456 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405532009457 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 405532009458 NodB motif; other site 405532009459 active site 405532009460 catalytic site [active] 405532009461 metal binding site [ion binding]; metal-binding site 405532009462 Small acid-soluble spore protein P family; Region: SspP; cl12105 405532009463 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405532009464 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 405532009465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532009466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532009467 putative substrate translocation pore; other site 405532009468 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 405532009469 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405532009470 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405532009471 nudix motif; other site 405532009472 SAP domain; Region: SAP; pfam02037 405532009473 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 405532009474 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405532009475 dimer interface [polypeptide binding]; other site 405532009476 active site 405532009477 acyl-CoA synthetase; Validated; Region: PRK07638 405532009478 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405532009479 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405532009480 acyl-activating enzyme (AAE) consensus motif; other site 405532009481 acyl-activating enzyme (AAE) consensus motif; other site 405532009482 AMP binding site [chemical binding]; other site 405532009483 active site 405532009484 CoA binding site [chemical binding]; other site 405532009485 BioY family; Region: BioY; pfam02632 405532009486 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 405532009487 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 405532009488 dimer interface [polypeptide binding]; other site 405532009489 acyl-activating enzyme (AAE) consensus motif; other site 405532009490 putative active site [active] 405532009491 AMP binding site [chemical binding]; other site 405532009492 putative CoA binding site [chemical binding]; other site 405532009493 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532009494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532009495 Coenzyme A binding pocket [chemical binding]; other site 405532009496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532009497 Coenzyme A binding pocket [chemical binding]; other site 405532009498 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 405532009499 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405532009500 amidase catalytic site [active] 405532009501 Zn binding residues [ion binding]; other site 405532009502 substrate binding site [chemical binding]; other site 405532009503 active site 405532009504 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 405532009505 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532009506 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532009507 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532009508 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532009509 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 405532009510 dimer interface [polypeptide binding]; other site 405532009511 putative metal binding site [ion binding]; other site 405532009512 PAS domain S-box; Region: sensory_box; TIGR00229 405532009513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532009514 putative active site [active] 405532009515 heme pocket [chemical binding]; other site 405532009516 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405532009517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532009518 putative active site [active] 405532009519 heme pocket [chemical binding]; other site 405532009520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532009521 dimer interface [polypeptide binding]; other site 405532009522 phosphorylation site [posttranslational modification] 405532009523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532009524 ATP binding site [chemical binding]; other site 405532009525 Mg2+ binding site [ion binding]; other site 405532009526 G-X-G motif; other site 405532009527 Predicted esterase [General function prediction only]; Region: COG0400 405532009528 putative hydrolase; Provisional; Region: PRK11460 405532009529 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405532009530 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532009531 Zn binding site [ion binding]; other site 405532009532 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405532009533 Zn binding site [ion binding]; other site 405532009534 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 405532009535 Na binding site [ion binding]; other site 405532009536 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 405532009537 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 405532009538 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 405532009539 active site 405532009540 FMN binding site [chemical binding]; other site 405532009541 substrate binding site [chemical binding]; other site 405532009542 3Fe-4S cluster binding site [ion binding]; other site 405532009543 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405532009544 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 405532009545 FMN binding site [chemical binding]; other site 405532009546 active site 405532009547 substrate binding site [chemical binding]; other site 405532009548 catalytic residue [active] 405532009549 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 405532009550 agmatinase; Region: agmatinase; TIGR01230 405532009551 Agmatinase-like family; Region: Agmatinase-like; cd09990 405532009552 active site 405532009553 oligomer interface [polypeptide binding]; other site 405532009554 Mn binding site [ion binding]; other site 405532009555 imidazolonepropionase; Validated; Region: PRK09356 405532009556 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 405532009557 active site 405532009558 urocanate hydratase; Provisional; Region: PRK05414 405532009559 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 405532009560 active sites [active] 405532009561 tetramer interface [polypeptide binding]; other site 405532009562 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 405532009563 hexamer interface [polypeptide binding]; other site 405532009564 RNA binding site [nucleotide binding]; other site 405532009565 Histidine-zinc binding site [chemical binding]; other site 405532009566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532009567 S-adenosylmethionine binding site [chemical binding]; other site 405532009568 DJ-1 family protein; Region: not_thiJ; TIGR01383 405532009569 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405532009570 conserved cys residue [active] 405532009571 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405532009572 AAA domain; Region: AAA_28; pfam13521 405532009573 active site 405532009574 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 405532009575 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405532009576 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 405532009577 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 405532009578 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405532009579 EamA-like transporter family; Region: EamA; pfam00892 405532009580 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 405532009581 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405532009582 metal binding site [ion binding]; metal-binding site 405532009583 dimer interface [polypeptide binding]; other site 405532009584 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 405532009585 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405532009586 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532009587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532009588 Walker A/P-loop; other site 405532009589 ATP binding site [chemical binding]; other site 405532009590 Q-loop/lid; other site 405532009591 ABC transporter signature motif; other site 405532009592 Walker B; other site 405532009593 D-loop; other site 405532009594 H-loop/switch region; other site 405532009595 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 405532009596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532009597 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 405532009598 putative dimerization interface [polypeptide binding]; other site 405532009599 putative substrate binding pocket [chemical binding]; other site 405532009600 holin-like protein; Validated; Region: PRK01658 405532009601 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405532009602 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405532009603 nudix motif; other site 405532009604 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 405532009605 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405532009606 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 405532009607 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405532009608 active site 405532009609 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532009610 Bacterial SH3 domain; Region: SH3_3; cl17532 405532009611 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405532009612 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532009613 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405532009614 Walker A/P-loop; other site 405532009615 ATP binding site [chemical binding]; other site 405532009616 Q-loop/lid; other site 405532009617 ABC transporter signature motif; other site 405532009618 Walker B; other site 405532009619 D-loop; other site 405532009620 H-loop/switch region; other site 405532009621 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532009622 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 405532009623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532009624 Walker A/P-loop; other site 405532009625 ATP binding site [chemical binding]; other site 405532009626 Q-loop/lid; other site 405532009627 ABC transporter signature motif; other site 405532009628 Walker B; other site 405532009629 D-loop; other site 405532009630 H-loop/switch region; other site 405532009631 hypothetical protein; Provisional; Region: PRK01844 405532009632 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 405532009633 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 405532009634 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405532009635 TPP-binding site [chemical binding]; other site 405532009636 dimer interface [polypeptide binding]; other site 405532009637 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405532009638 PYR/PP interface [polypeptide binding]; other site 405532009639 dimer interface [polypeptide binding]; other site 405532009640 TPP binding site [chemical binding]; other site 405532009641 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405532009642 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405532009643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532009644 dimer interface [polypeptide binding]; other site 405532009645 conserved gate region; other site 405532009646 ABC-ATPase subunit interface; other site 405532009647 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405532009648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532009649 dimer interface [polypeptide binding]; other site 405532009650 conserved gate region; other site 405532009651 ABC-ATPase subunit interface; other site 405532009652 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 405532009653 Walker A/P-loop; other site 405532009654 ATP binding site [chemical binding]; other site 405532009655 ABC transporter; Region: ABC_tran; pfam00005 405532009656 Q-loop/lid; other site 405532009657 ABC transporter signature motif; other site 405532009658 Walker B; other site 405532009659 D-loop; other site 405532009660 H-loop/switch region; other site 405532009661 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 405532009662 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405532009663 membrane-bound complex binding site; other site 405532009664 hinge residues; other site 405532009665 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405532009666 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405532009667 active site 405532009668 metal binding site [ion binding]; metal-binding site 405532009669 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405532009670 hypothetical protein; Provisional; Region: PRK01546 405532009671 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405532009672 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405532009673 catalytic residues [active] 405532009674 catalytic nucleophile [active] 405532009675 LexA repressor; Validated; Region: PRK00215 405532009676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532009677 putative DNA binding site [nucleotide binding]; other site 405532009678 putative Zn2+ binding site [ion binding]; other site 405532009679 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405532009680 Catalytic site [active] 405532009681 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405532009682 Uncharacterized conserved protein [Function unknown]; Region: COG3595 405532009683 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405532009684 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 405532009685 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532009686 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405532009687 glutamine synthetase, type I; Region: GlnA; TIGR00653 405532009688 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 405532009689 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 405532009690 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 405532009691 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405532009692 DNA binding residues [nucleotide binding] 405532009693 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 405532009694 Aluminium resistance protein; Region: Alum_res; pfam06838 405532009695 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 405532009696 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405532009697 HflX GTPase family; Region: HflX; cd01878 405532009698 G1 box; other site 405532009699 GTP/Mg2+ binding site [chemical binding]; other site 405532009700 Switch I region; other site 405532009701 G2 box; other site 405532009702 G3 box; other site 405532009703 Switch II region; other site 405532009704 G4 box; other site 405532009705 G5 box; other site 405532009706 Predicted membrane protein [Function unknown]; Region: COG2860 405532009707 UPF0126 domain; Region: UPF0126; pfam03458 405532009708 UPF0126 domain; Region: UPF0126; pfam03458 405532009709 stage V sporulation protein K; Region: spore_V_K; TIGR02881 405532009710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532009711 Walker A motif; other site 405532009712 ATP binding site [chemical binding]; other site 405532009713 Walker B motif; other site 405532009714 arginine finger; other site 405532009715 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 405532009716 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405532009717 active site 405532009718 catalytic residues [active] 405532009719 DNA binding site [nucleotide binding] 405532009720 Int/Topo IB signature motif; other site 405532009721 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 405532009722 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 405532009723 bacterial Hfq-like; Region: Hfq; cd01716 405532009724 hexamer interface [polypeptide binding]; other site 405532009725 Sm1 motif; other site 405532009726 RNA binding site [nucleotide binding]; other site 405532009727 Sm2 motif; other site 405532009728 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 405532009729 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 405532009730 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532009731 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532009732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405532009733 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 405532009734 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405532009735 active site 405532009736 phosphorylation site [posttranslational modification] 405532009737 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 405532009738 active site 405532009739 P-loop; other site 405532009740 phosphorylation site [posttranslational modification] 405532009741 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 405532009742 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 405532009743 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 405532009744 putative substrate binding site [chemical binding]; other site 405532009745 putative ATP binding site [chemical binding]; other site 405532009746 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405532009747 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405532009748 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405532009749 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 405532009750 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 405532009751 dimer interface [polypeptide binding]; other site 405532009752 active site 405532009753 metal binding site [ion binding]; metal-binding site 405532009754 Predicted membrane protein [Function unknown]; Region: COG2322 405532009755 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 405532009756 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 405532009757 Glyco_18 domain; Region: Glyco_18; smart00636 405532009758 putative active site [active] 405532009759 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405532009760 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532009761 putative active site [active] 405532009762 putative metal binding site [ion binding]; other site 405532009763 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405532009764 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405532009765 IHF dimer interface [polypeptide binding]; other site 405532009766 IHF - DNA interface [nucleotide binding]; other site 405532009767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405532009768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532009769 Coenzyme A binding pocket [chemical binding]; other site 405532009770 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405532009771 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405532009772 metal-binding site [ion binding] 405532009773 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405532009774 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405532009775 metal-binding site [ion binding] 405532009776 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405532009777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532009778 motif II; other site 405532009779 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405532009780 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405532009781 metal-binding site [ion binding] 405532009782 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 405532009783 putative homodimer interface [polypeptide binding]; other site 405532009784 putative homotetramer interface [polypeptide binding]; other site 405532009785 putative allosteric switch controlling residues; other site 405532009786 putative metal binding site [ion binding]; other site 405532009787 putative homodimer-homodimer interface [polypeptide binding]; other site 405532009788 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405532009789 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405532009790 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405532009791 Walker A/P-loop; other site 405532009792 ATP binding site [chemical binding]; other site 405532009793 Q-loop/lid; other site 405532009794 ABC transporter signature motif; other site 405532009795 Walker B; other site 405532009796 D-loop; other site 405532009797 H-loop/switch region; other site 405532009798 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405532009799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532009800 ABC-ATPase subunit interface; other site 405532009801 dimer interface [polypeptide binding]; other site 405532009802 putative PBP binding regions; other site 405532009803 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405532009804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532009805 ABC-ATPase subunit interface; other site 405532009806 dimer interface [polypeptide binding]; other site 405532009807 putative PBP binding regions; other site 405532009808 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405532009809 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 405532009810 putative ligand binding residues [chemical binding]; other site 405532009811 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 405532009812 active site 405532009813 putative catalytic site [active] 405532009814 DNA binding site [nucleotide binding] 405532009815 putative phosphate binding site [ion binding]; other site 405532009816 metal binding site A [ion binding]; metal-binding site 405532009817 AP binding site [nucleotide binding]; other site 405532009818 metal binding site B [ion binding]; metal-binding site 405532009819 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 405532009820 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 405532009821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532009822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532009823 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405532009824 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405532009825 DNA binding site [nucleotide binding] 405532009826 active site 405532009827 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 405532009828 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405532009829 endonuclease III; Region: ENDO3c; smart00478 405532009830 minor groove reading motif; other site 405532009831 helix-hairpin-helix signature motif; other site 405532009832 substrate binding pocket [chemical binding]; other site 405532009833 active site 405532009834 peptidase T; Region: peptidase-T; TIGR01882 405532009835 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 405532009836 metal binding site [ion binding]; metal-binding site 405532009837 dimer interface [polypeptide binding]; other site 405532009838 hypothetical protein; Provisional; Region: PRK06764 405532009839 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405532009840 catalytic core [active] 405532009841 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532009842 PAS domain S-box; Region: sensory_box; TIGR00229 405532009843 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532009844 putative active site [active] 405532009845 heme pocket [chemical binding]; other site 405532009846 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405532009847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405532009848 metal binding site [ion binding]; metal-binding site 405532009849 active site 405532009850 I-site; other site 405532009851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405532009852 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 405532009853 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405532009854 active site 405532009855 homodimer interface [polypeptide binding]; other site 405532009856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532009857 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405532009858 NAD(P) binding site [chemical binding]; other site 405532009859 active site 405532009860 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 405532009861 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 405532009862 NAD(P) binding site [chemical binding]; other site 405532009863 homodimer interface [polypeptide binding]; other site 405532009864 substrate binding site [chemical binding]; other site 405532009865 active site 405532009866 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 405532009867 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 405532009868 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405532009869 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405532009870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532009871 DNA-binding site [nucleotide binding]; DNA binding site 405532009872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532009873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532009874 homodimer interface [polypeptide binding]; other site 405532009875 catalytic residue [active] 405532009876 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532009877 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 405532009878 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 405532009879 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 405532009880 active site 405532009881 catalytic site [active] 405532009882 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 405532009883 putative active site [active] 405532009884 putative catalytic triad [active] 405532009885 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405532009886 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405532009887 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 405532009888 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405532009889 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405532009890 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 405532009891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405532009892 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405532009893 Sulfatase; Region: Sulfatase; pfam00884 405532009894 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405532009895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532009896 binding surface 405532009897 TPR motif; other site 405532009898 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405532009899 G1 box; other site 405532009900 GTP/Mg2+ binding site [chemical binding]; other site 405532009901 Switch I region; other site 405532009902 G3 box; other site 405532009903 Switch II region; other site 405532009904 G4 box; other site 405532009905 G5 box; other site 405532009906 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 405532009907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532009908 ATP binding site [chemical binding]; other site 405532009909 Mg2+ binding site [ion binding]; other site 405532009910 G-X-G motif; other site 405532009911 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 405532009912 ATP binding site [chemical binding]; other site 405532009913 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 405532009914 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 405532009915 MutS domain I; Region: MutS_I; pfam01624 405532009916 MutS domain II; Region: MutS_II; pfam05188 405532009917 MutS domain III; Region: MutS_III; pfam05192 405532009918 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 405532009919 Walker A/P-loop; other site 405532009920 ATP binding site [chemical binding]; other site 405532009921 Q-loop/lid; other site 405532009922 ABC transporter signature motif; other site 405532009923 Walker B; other site 405532009924 D-loop; other site 405532009925 H-loop/switch region; other site 405532009926 Outer spore coat protein E (CotE); Region: CotE; pfam10628 405532009927 Predicted membrane protein [Function unknown]; Region: COG4550 405532009928 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 405532009929 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405532009930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532009931 FeS/SAM binding site; other site 405532009932 TRAM domain; Region: TRAM; pfam01938 405532009933 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 405532009934 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 405532009935 TPP-binding site [chemical binding]; other site 405532009936 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 405532009937 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 405532009938 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 405532009939 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 405532009940 dimer interface [polypeptide binding]; other site 405532009941 PYR/PP interface [polypeptide binding]; other site 405532009942 TPP binding site [chemical binding]; other site 405532009943 substrate binding site [chemical binding]; other site 405532009944 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405532009945 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 405532009946 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 405532009947 active site 405532009948 dimer interface [polypeptide binding]; other site 405532009949 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 405532009950 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 405532009951 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405532009952 putative active site [active] 405532009953 metal binding site [ion binding]; metal-binding site 405532009954 homodimer binding site [polypeptide binding]; other site 405532009955 phosphodiesterase; Provisional; Region: PRK12704 405532009956 Uncharacterized conserved protein [Function unknown]; Region: COG3334 405532009957 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532009958 Zn2+ binding site [ion binding]; other site 405532009959 Mg2+ binding site [ion binding]; other site 405532009960 recombinase A; Provisional; Region: recA; PRK09354 405532009961 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 405532009962 hexamer interface [polypeptide binding]; other site 405532009963 Walker A motif; other site 405532009964 ATP binding site [chemical binding]; other site 405532009965 Walker B motif; other site 405532009966 competence damage-inducible protein A; Provisional; Region: PRK00549 405532009967 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 405532009968 putative MPT binding site; other site 405532009969 Competence-damaged protein; Region: CinA; pfam02464 405532009970 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 405532009971 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 405532009972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532009973 non-specific DNA binding site [nucleotide binding]; other site 405532009974 salt bridge; other site 405532009975 sequence-specific DNA binding site [nucleotide binding]; other site 405532009976 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 405532009977 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405532009978 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 405532009979 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 405532009980 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 405532009981 classical (c) SDRs; Region: SDR_c; cd05233 405532009982 NAD(P) binding site [chemical binding]; other site 405532009983 active site 405532009984 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405532009985 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405532009986 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405532009987 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405532009988 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405532009989 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405532009990 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405532009991 TM-ABC transporter signature motif; other site 405532009992 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405532009993 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405532009994 TM-ABC transporter signature motif; other site 405532009995 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 405532009996 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405532009997 Walker A/P-loop; other site 405532009998 ATP binding site [chemical binding]; other site 405532009999 Q-loop/lid; other site 405532010000 ABC transporter signature motif; other site 405532010001 Walker B; other site 405532010002 D-loop; other site 405532010003 H-loop/switch region; other site 405532010004 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405532010005 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 405532010006 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 405532010007 ligand binding site [chemical binding]; other site 405532010008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532010009 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405532010010 DNA-binding site [nucleotide binding]; DNA binding site 405532010011 UTRA domain; Region: UTRA; pfam07702 405532010012 Tetraspanin family; Region: Tetraspannin; pfam00335 405532010013 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405532010014 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405532010015 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405532010016 YlzJ-like protein; Region: YlzJ; pfam14035 405532010017 Clp protease; Region: CLP_protease; pfam00574 405532010018 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 405532010019 active site 405532010020 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405532010021 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532010022 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405532010023 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 405532010024 dihydrodipicolinate synthase; Region: dapA; TIGR00674 405532010025 dimer interface [polypeptide binding]; other site 405532010026 active site 405532010027 catalytic residue [active] 405532010028 aspartate kinase I; Reviewed; Region: PRK08210 405532010029 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 405532010030 nucleotide binding site [chemical binding]; other site 405532010031 substrate binding site [chemical binding]; other site 405532010032 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 405532010033 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405532010034 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 405532010035 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405532010036 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 405532010037 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 405532010038 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 405532010039 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 405532010040 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405532010041 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405532010042 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405532010043 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 405532010044 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 405532010045 NodB motif; other site 405532010046 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 405532010047 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 405532010048 RNase E interface [polypeptide binding]; other site 405532010049 trimer interface [polypeptide binding]; other site 405532010050 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 405532010051 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 405532010052 RNase E interface [polypeptide binding]; other site 405532010053 trimer interface [polypeptide binding]; other site 405532010054 active site 405532010055 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 405532010056 putative nucleic acid binding region [nucleotide binding]; other site 405532010057 G-X-X-G motif; other site 405532010058 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 405532010059 RNA binding site [nucleotide binding]; other site 405532010060 domain interface; other site 405532010061 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 405532010062 16S/18S rRNA binding site [nucleotide binding]; other site 405532010063 S13e-L30e interaction site [polypeptide binding]; other site 405532010064 25S rRNA binding site [nucleotide binding]; other site 405532010065 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 405532010066 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 405532010067 active site 405532010068 Riboflavin kinase; Region: Flavokinase; pfam01687 405532010069 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 405532010070 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 405532010071 RNA binding site [nucleotide binding]; other site 405532010072 active site 405532010073 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 405532010074 Protein of unknown function (DUF503); Region: DUF503; pfam04456 405532010075 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405532010076 translation initiation factor IF-2; Region: IF-2; TIGR00487 405532010077 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405532010078 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 405532010079 G1 box; other site 405532010080 putative GEF interaction site [polypeptide binding]; other site 405532010081 GTP/Mg2+ binding site [chemical binding]; other site 405532010082 Switch I region; other site 405532010083 G2 box; other site 405532010084 G3 box; other site 405532010085 Switch II region; other site 405532010086 G4 box; other site 405532010087 G5 box; other site 405532010088 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 405532010089 Translation-initiation factor 2; Region: IF-2; pfam11987 405532010090 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 405532010091 hypothetical protein; Provisional; Region: PRK07714 405532010092 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 405532010093 putative RNA binding cleft [nucleotide binding]; other site 405532010094 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 405532010095 NusA N-terminal domain; Region: NusA_N; pfam08529 405532010096 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 405532010097 RNA binding site [nucleotide binding]; other site 405532010098 homodimer interface [polypeptide binding]; other site 405532010099 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405532010100 G-X-X-G motif; other site 405532010101 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405532010102 G-X-X-G motif; other site 405532010103 ribosome maturation protein RimP; Reviewed; Region: PRK00092 405532010104 Sm and related proteins; Region: Sm_like; cl00259 405532010105 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 405532010106 putative oligomer interface [polypeptide binding]; other site 405532010107 putative RNA binding site [nucleotide binding]; other site 405532010108 DNA polymerase III PolC; Validated; Region: polC; PRK00448 405532010109 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 405532010110 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 405532010111 generic binding surface II; other site 405532010112 generic binding surface I; other site 405532010113 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405532010114 active site 405532010115 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405532010116 active site 405532010117 catalytic site [active] 405532010118 substrate binding site [chemical binding]; other site 405532010119 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 405532010120 prolyl-tRNA synthetase; Provisional; Region: PRK09194 405532010121 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 405532010122 dimer interface [polypeptide binding]; other site 405532010123 motif 1; other site 405532010124 active site 405532010125 motif 2; other site 405532010126 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 405532010127 putative deacylase active site [active] 405532010128 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405532010129 active site 405532010130 motif 3; other site 405532010131 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 405532010132 anticodon binding site; other site 405532010133 RIP metalloprotease RseP; Region: TIGR00054 405532010134 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405532010135 active site 405532010136 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 405532010137 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405532010138 protein binding site [polypeptide binding]; other site 405532010139 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405532010140 putative substrate binding region [chemical binding]; other site 405532010141 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 405532010142 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 405532010143 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 405532010144 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 405532010145 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 405532010146 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 405532010147 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 405532010148 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 405532010149 catalytic residue [active] 405532010150 putative FPP diphosphate binding site; other site 405532010151 putative FPP binding hydrophobic cleft; other site 405532010152 dimer interface [polypeptide binding]; other site 405532010153 putative IPP diphosphate binding site; other site 405532010154 ribosome recycling factor; Reviewed; Region: frr; PRK00083 405532010155 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 405532010156 hinge region; other site 405532010157 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405532010158 putative nucleotide binding site [chemical binding]; other site 405532010159 uridine monophosphate binding site [chemical binding]; other site 405532010160 homohexameric interface [polypeptide binding]; other site 405532010161 elongation factor Ts; Provisional; Region: tsf; PRK09377 405532010162 UBA/TS-N domain; Region: UBA; pfam00627 405532010163 Elongation factor TS; Region: EF_TS; pfam00889 405532010164 Elongation factor TS; Region: EF_TS; pfam00889 405532010165 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 405532010166 rRNA interaction site [nucleotide binding]; other site 405532010167 S8 interaction site; other site 405532010168 putative laminin-1 binding site; other site 405532010169 transcriptional repressor CodY; Validated; Region: PRK04158 405532010170 CodY GAF-like domain; Region: CodY; pfam06018 405532010171 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 405532010172 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 405532010173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532010174 Walker A motif; other site 405532010175 ATP binding site [chemical binding]; other site 405532010176 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 405532010177 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405532010178 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 405532010179 active site 405532010180 HslU subunit interaction site [polypeptide binding]; other site 405532010181 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 405532010182 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405532010183 active site 405532010184 Int/Topo IB signature motif; other site 405532010185 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 405532010186 Glucose inhibited division protein A; Region: GIDA; pfam01134 405532010187 DNA topoisomerase I; Validated; Region: PRK05582 405532010188 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 405532010189 active site 405532010190 interdomain interaction site; other site 405532010191 putative metal-binding site [ion binding]; other site 405532010192 nucleotide binding site [chemical binding]; other site 405532010193 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405532010194 domain I; other site 405532010195 DNA binding groove [nucleotide binding] 405532010196 phosphate binding site [ion binding]; other site 405532010197 domain II; other site 405532010198 domain III; other site 405532010199 nucleotide binding site [chemical binding]; other site 405532010200 catalytic site [active] 405532010201 domain IV; other site 405532010202 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405532010203 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405532010204 DNA protecting protein DprA; Region: dprA; TIGR00732 405532010205 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 405532010206 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 405532010207 CoA binding domain; Region: CoA_binding; smart00881 405532010208 CoA-ligase; Region: Ligase_CoA; pfam00549 405532010209 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 405532010210 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 405532010211 CoA-ligase; Region: Ligase_CoA; pfam00549 405532010212 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 405532010213 RNA/DNA hybrid binding site [nucleotide binding]; other site 405532010214 active site 405532010215 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 405532010216 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 405532010217 GTP/Mg2+ binding site [chemical binding]; other site 405532010218 G4 box; other site 405532010219 G5 box; other site 405532010220 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 405532010221 G1 box; other site 405532010222 G1 box; other site 405532010223 GTP/Mg2+ binding site [chemical binding]; other site 405532010224 Switch I region; other site 405532010225 G2 box; other site 405532010226 G2 box; other site 405532010227 G3 box; other site 405532010228 G3 box; other site 405532010229 Switch II region; other site 405532010230 Switch II region; other site 405532010231 G4 box; other site 405532010232 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405532010233 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405532010234 Catalytic site [active] 405532010235 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 405532010236 Ribosomal protein L19 leader 405532010237 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 405532010238 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 405532010239 RimM N-terminal domain; Region: RimM; pfam01782 405532010240 PRC-barrel domain; Region: PRC; pfam05239 405532010241 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 405532010242 KH domain; Region: KH_4; pfam13083 405532010243 G-X-X-G motif; other site 405532010244 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 405532010245 signal recognition particle protein; Provisional; Region: PRK10867 405532010246 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 405532010247 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405532010248 P loop; other site 405532010249 GTP binding site [chemical binding]; other site 405532010250 Signal peptide binding domain; Region: SRP_SPB; pfam02978 405532010251 putative DNA-binding protein; Validated; Region: PRK00118 405532010252 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 405532010253 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 405532010254 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 405532010255 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405532010256 P loop; other site 405532010257 GTP binding site [chemical binding]; other site 405532010258 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 405532010259 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405532010260 Walker A/P-loop; other site 405532010261 ATP binding site [chemical binding]; other site 405532010262 Q-loop/lid; other site 405532010263 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 405532010264 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405532010265 ABC transporter signature motif; other site 405532010266 Walker B; other site 405532010267 D-loop; other site 405532010268 H-loop/switch region; other site 405532010269 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 405532010270 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 405532010271 dimerization interface [polypeptide binding]; other site 405532010272 active site 405532010273 metal binding site [ion binding]; metal-binding site 405532010274 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 405532010275 dsRNA binding site [nucleotide binding]; other site 405532010276 acyl carrier protein; Provisional; Region: acpP; PRK00982 405532010277 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 405532010278 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405532010279 NAD(P) binding site [chemical binding]; other site 405532010280 homotetramer interface [polypeptide binding]; other site 405532010281 homodimer interface [polypeptide binding]; other site 405532010282 active site 405532010283 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 405532010284 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 405532010285 putative phosphate acyltransferase; Provisional; Region: PRK05331 405532010286 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 405532010287 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 405532010288 active site 2 [active] 405532010289 active site 1 [active] 405532010290 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 405532010291 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 405532010292 generic binding surface II; other site 405532010293 ssDNA binding site; other site 405532010294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532010295 ATP binding site [chemical binding]; other site 405532010296 putative Mg++ binding site [ion binding]; other site 405532010297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532010298 nucleotide binding region [chemical binding]; other site 405532010299 ATP-binding site [chemical binding]; other site 405532010300 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 405532010301 DAK2 domain; Region: Dak2; pfam02734 405532010302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 405532010303 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 405532010304 Thiamine pyrophosphokinase; Region: TPK; cd07995 405532010305 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 405532010306 active site 405532010307 dimerization interface [polypeptide binding]; other site 405532010308 thiamine binding site [chemical binding]; other site 405532010309 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 405532010310 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 405532010311 substrate binding site [chemical binding]; other site 405532010312 hexamer interface [polypeptide binding]; other site 405532010313 metal binding site [ion binding]; metal-binding site 405532010314 GTPase RsgA; Reviewed; Region: PRK00098 405532010315 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 405532010316 RNA binding site [nucleotide binding]; other site 405532010317 homodimer interface [polypeptide binding]; other site 405532010318 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405532010319 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405532010320 GTP/Mg2+ binding site [chemical binding]; other site 405532010321 G4 box; other site 405532010322 G5 box; other site 405532010323 G1 box; other site 405532010324 Switch I region; other site 405532010325 G2 box; other site 405532010326 G3 box; other site 405532010327 Switch II region; other site 405532010328 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 405532010329 Catalytic domain of Protein Kinases; Region: PKc; cd00180 405532010330 active site 405532010331 ATP binding site [chemical binding]; other site 405532010332 substrate binding site [chemical binding]; other site 405532010333 activation loop (A-loop); other site 405532010334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 405532010335 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405532010336 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405532010337 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405532010338 Protein phosphatase 2C; Region: PP2C; pfam00481 405532010339 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 405532010340 active site 405532010341 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 405532010342 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532010343 FeS/SAM binding site; other site 405532010344 16S rRNA methyltransferase B; Provisional; Region: PRK14902 405532010345 NusB family; Region: NusB; pfam01029 405532010346 putative RNA binding site [nucleotide binding]; other site 405532010347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532010348 S-adenosylmethionine binding site [chemical binding]; other site 405532010349 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 405532010350 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 405532010351 putative active site [active] 405532010352 substrate binding site [chemical binding]; other site 405532010353 putative cosubstrate binding site; other site 405532010354 catalytic site [active] 405532010355 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 405532010356 substrate binding site [chemical binding]; other site 405532010357 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405532010358 active site 405532010359 catalytic residues [active] 405532010360 metal binding site [ion binding]; metal-binding site 405532010361 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 405532010362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532010363 ATP binding site [chemical binding]; other site 405532010364 putative Mg++ binding site [ion binding]; other site 405532010365 helicase superfamily c-terminal domain; Region: HELICc; smart00490 405532010366 nucleotide binding region [chemical binding]; other site 405532010367 ATP-binding site [chemical binding]; other site 405532010368 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 405532010369 Flavoprotein; Region: Flavoprotein; pfam02441 405532010370 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 405532010371 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 405532010372 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 405532010373 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 405532010374 catalytic site [active] 405532010375 G-X2-G-X-G-K; other site 405532010376 hypothetical protein; Provisional; Region: PRK04323 405532010377 hypothetical protein; Provisional; Region: PRK11820 405532010378 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 405532010379 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 405532010380 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405532010381 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405532010382 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405532010383 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405532010384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532010385 motif II; other site 405532010386 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405532010387 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 405532010388 Domain of unknown function (DUF814); Region: DUF814; pfam05670 405532010389 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405532010390 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405532010391 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405532010392 active site 405532010393 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405532010394 DinB superfamily; Region: DinB_2; pfam12867 405532010395 YoqO-like protein; Region: YoqO; pfam14037 405532010396 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 405532010397 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 405532010398 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532010399 active site 405532010400 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 405532010401 active site 405532010402 dimer interface [polypeptide binding]; other site 405532010403 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 405532010404 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 405532010405 heterodimer interface [polypeptide binding]; other site 405532010406 active site 405532010407 FMN binding site [chemical binding]; other site 405532010408 homodimer interface [polypeptide binding]; other site 405532010409 substrate binding site [chemical binding]; other site 405532010410 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 405532010411 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 405532010412 FAD binding pocket [chemical binding]; other site 405532010413 FAD binding motif [chemical binding]; other site 405532010414 phosphate binding motif [ion binding]; other site 405532010415 beta-alpha-beta structure motif; other site 405532010416 NAD binding pocket [chemical binding]; other site 405532010417 Iron coordination center [ion binding]; other site 405532010418 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 405532010419 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405532010420 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405532010421 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 405532010422 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405532010423 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405532010424 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 405532010425 IMP binding site; other site 405532010426 dimer interface [polypeptide binding]; other site 405532010427 interdomain contacts; other site 405532010428 partial ornithine binding site; other site 405532010429 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 405532010430 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 405532010431 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 405532010432 catalytic site [active] 405532010433 subunit interface [polypeptide binding]; other site 405532010434 dihydroorotase; Validated; Region: pyrC; PRK09357 405532010435 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405532010436 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 405532010437 active site 405532010438 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 405532010439 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405532010440 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405532010441 PyrR binding site 405532010442 uracil transporter; Provisional; Region: PRK10720 405532010443 PyrR binding site 405532010444 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 405532010445 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532010446 active site 405532010447 PyrR binding site 405532010448 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 405532010449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532010450 RNA binding surface [nucleotide binding]; other site 405532010451 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405532010452 active site 405532010453 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 405532010454 lipoprotein signal peptidase; Provisional; Region: PRK14787 405532010455 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 405532010456 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 405532010457 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405532010458 active site 405532010459 HIGH motif; other site 405532010460 nucleotide binding site [chemical binding]; other site 405532010461 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405532010462 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405532010463 active site 405532010464 KMSKS motif; other site 405532010465 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 405532010466 tRNA binding surface [nucleotide binding]; other site 405532010467 anticodon binding site; other site 405532010468 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405532010469 DivIVA protein; Region: DivIVA; pfam05103 405532010470 DivIVA domain; Region: DivI1A_domain; TIGR03544 405532010471 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 405532010472 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 405532010473 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532010474 RNA binding surface [nucleotide binding]; other site 405532010475 YGGT family; Region: YGGT; pfam02325 405532010476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 405532010477 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 405532010478 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405532010479 catalytic residue [active] 405532010480 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 405532010481 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 405532010482 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 405532010483 sporulation sigma factor SigG; Reviewed; Region: PRK08215 405532010484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532010485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532010486 DNA binding residues [nucleotide binding] 405532010487 sporulation sigma factor SigE; Reviewed; Region: PRK08301 405532010488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532010489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532010490 DNA binding residues [nucleotide binding] 405532010491 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 405532010492 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 405532010493 cell division protein FtsZ; Validated; Region: PRK09330 405532010494 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 405532010495 nucleotide binding site [chemical binding]; other site 405532010496 SulA interaction site; other site 405532010497 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 405532010498 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405532010499 nucleotide binding site [chemical binding]; other site 405532010500 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 405532010501 Cell division protein FtsA; Region: FtsA; pfam14450 405532010502 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 405532010503 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 405532010504 Cell division protein FtsQ; Region: FtsQ; pfam03799 405532010505 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 405532010506 FAD binding domain; Region: FAD_binding_4; pfam01565 405532010507 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405532010508 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 405532010509 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405532010510 active site 405532010511 homodimer interface [polypeptide binding]; other site 405532010512 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 405532010513 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 405532010514 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 405532010515 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405532010516 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405532010517 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 405532010518 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 405532010519 Mg++ binding site [ion binding]; other site 405532010520 putative catalytic motif [active] 405532010521 putative substrate binding site [chemical binding]; other site 405532010522 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 405532010523 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405532010524 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405532010525 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405532010526 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 405532010527 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532010528 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532010529 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 405532010530 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405532010531 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532010532 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532010533 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 405532010534 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 405532010535 Cell division protein FtsL; Region: FtsL; cl11433 405532010536 MraW methylase family; Region: Methyltransf_5; pfam01795 405532010537 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 405532010538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 405532010539 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 405532010540 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 405532010541 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405532010542 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405532010543 hypothetical protein; Provisional; Region: PRK13688 405532010544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532010545 Coenzyme A binding pocket [chemical binding]; other site 405532010546 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405532010547 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405532010548 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 405532010549 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 405532010550 hypothetical protein; Provisional; Region: PRK13670 405532010551 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 405532010552 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 405532010553 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 405532010554 protein binding site [polypeptide binding]; other site 405532010555 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405532010556 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 405532010557 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 405532010558 active site 405532010559 nucleophile elbow; other site 405532010560 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 405532010561 Nucleoside recognition; Region: Gate; pfam07670 405532010562 Nucleoside recognition; Region: Gate; pfam07670 405532010563 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 405532010564 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 405532010565 active site 405532010566 (T/H)XGH motif; other site 405532010567 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 405532010568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532010569 S-adenosylmethionine binding site [chemical binding]; other site 405532010570 ylbH leader 405532010571 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 405532010572 Protein of unknown function (DUF964); Region: DUF964; pfam06133 405532010573 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405532010574 catalytic core [active] 405532010575 YlbE-like protein; Region: YlbE; pfam14003 405532010576 Putative coat protein; Region: YlbD_coat; pfam14071 405532010577 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 405532010578 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 405532010579 YugN-like family; Region: YugN; pfam08868 405532010580 formamidase; Provisional; Region: amiF; PRK13287 405532010581 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 405532010582 multimer interface [polypeptide binding]; other site 405532010583 active site 405532010584 catalytic triad [active] 405532010585 dimer interface [polypeptide binding]; other site 405532010586 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 405532010587 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 405532010588 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 405532010589 Subunit I/III interface [polypeptide binding]; other site 405532010590 Subunit III/IV interface [polypeptide binding]; other site 405532010591 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 405532010592 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 405532010593 D-pathway; other site 405532010594 Putative ubiquinol binding site [chemical binding]; other site 405532010595 Low-spin heme (heme b) binding site [chemical binding]; other site 405532010596 Putative water exit pathway; other site 405532010597 Binuclear center (heme o3/CuB) [ion binding]; other site 405532010598 K-pathway; other site 405532010599 Putative proton exit pathway; other site 405532010600 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 405532010601 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 405532010602 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 405532010603 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405532010604 Cytochrome c; Region: Cytochrom_C; pfam00034 405532010605 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 405532010606 UbiA prenyltransferase family; Region: UbiA; pfam01040 405532010607 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 405532010608 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 405532010609 pyruvate carboxylase; Reviewed; Region: PRK12999 405532010610 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405532010611 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405532010612 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405532010613 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 405532010614 active site 405532010615 catalytic residues [active] 405532010616 metal binding site [ion binding]; metal-binding site 405532010617 homodimer binding site [polypeptide binding]; other site 405532010618 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405532010619 carboxyltransferase (CT) interaction site; other site 405532010620 biotinylation site [posttranslational modification]; other site 405532010621 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 405532010622 hypothetical protein; Provisional; Region: PRK13666 405532010623 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 405532010624 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 405532010625 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 405532010626 putative active site [active] 405532010627 PhoH-like protein; Region: PhoH; pfam02562 405532010628 hypothetical protein; Provisional; Region: PRK06733 405532010629 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 405532010630 YlaH-like protein; Region: YlaH; pfam14036 405532010631 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 405532010632 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 405532010633 G1 box; other site 405532010634 putative GEF interaction site [polypeptide binding]; other site 405532010635 GTP/Mg2+ binding site [chemical binding]; other site 405532010636 Switch I region; other site 405532010637 G2 box; other site 405532010638 G3 box; other site 405532010639 Switch II region; other site 405532010640 G4 box; other site 405532010641 G5 box; other site 405532010642 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 405532010643 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 405532010644 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 405532010645 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 405532010646 active site 405532010647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 405532010648 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 405532010649 hypothetical protein; Provisional; Region: PRK04387 405532010650 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 405532010651 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405532010652 homodimer interface [polypeptide binding]; other site 405532010653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532010654 catalytic residue [active] 405532010655 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405532010656 transglutaminase; Provisional; Region: tgl; PRK03187 405532010657 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405532010658 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405532010659 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405532010660 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 405532010661 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 405532010662 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 405532010663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532010664 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405532010665 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405532010666 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405532010667 E3 interaction surface; other site 405532010668 lipoyl attachment site [posttranslational modification]; other site 405532010669 e3 binding domain; Region: E3_binding; pfam02817 405532010670 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405532010671 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405532010672 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405532010673 alpha subunit interface [polypeptide binding]; other site 405532010674 TPP binding site [chemical binding]; other site 405532010675 heterodimer interface [polypeptide binding]; other site 405532010676 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405532010677 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 405532010678 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405532010679 TPP-binding site [chemical binding]; other site 405532010680 heterodimer interface [polypeptide binding]; other site 405532010681 tetramer interface [polypeptide binding]; other site 405532010682 phosphorylation loop region [posttranslational modification] 405532010683 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405532010684 active site 405532010685 catalytic residues [active] 405532010686 metal binding site [ion binding]; metal-binding site 405532010687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532010688 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405532010689 active site 405532010690 motif I; other site 405532010691 motif II; other site 405532010692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532010693 hypothetical protein; Provisional; Region: PRK13667 405532010694 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405532010695 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532010696 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405532010697 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405532010698 TrkA-N domain; Region: TrkA_N; pfam02254 405532010699 TrkA-C domain; Region: TrkA_C; pfam02080 405532010700 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 405532010701 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405532010702 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 405532010703 metal binding site [ion binding]; metal-binding site 405532010704 putative dimer interface [polypeptide binding]; other site 405532010705 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 405532010706 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 405532010707 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 405532010708 trimer interface [polypeptide binding]; other site 405532010709 active site 405532010710 substrate binding site [chemical binding]; other site 405532010711 CoA binding site [chemical binding]; other site 405532010712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532010713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532010714 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532010715 dimerization interface [polypeptide binding]; other site 405532010716 FOG: CBS domain [General function prediction only]; Region: COG0517 405532010717 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 405532010718 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 405532010719 Protein of unknown function (DUF458); Region: DUF458; pfam04308 405532010720 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 405532010721 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 405532010722 catalytic residues [active] 405532010723 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 405532010724 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405532010725 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 405532010726 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 405532010727 short chain dehydrogenase; Provisional; Region: PRK07677 405532010728 NAD(P) binding site [chemical binding]; other site 405532010729 substrate binding site [chemical binding]; other site 405532010730 homotetramer interface [polypeptide binding]; other site 405532010731 active site 405532010732 homodimer interface [polypeptide binding]; other site 405532010733 phosphodiesterase YaeI; Provisional; Region: PRK11340 405532010734 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405532010735 putative active site [active] 405532010736 putative metal binding site [ion binding]; other site 405532010737 polyphosphate kinase; Provisional; Region: PRK05443 405532010738 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 405532010739 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 405532010740 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 405532010741 putative domain interface [polypeptide binding]; other site 405532010742 putative active site [active] 405532010743 catalytic site [active] 405532010744 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 405532010745 putative domain interface [polypeptide binding]; other site 405532010746 putative active site [active] 405532010747 catalytic site [active] 405532010748 exopolyphosphatase; Region: exo_poly_only; TIGR03706 405532010749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405532010750 nucleotide binding site [chemical binding]; other site 405532010751 YkyB-like protein; Region: YkyB; pfam14177 405532010752 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 405532010753 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405532010754 I-site; other site 405532010755 active site 405532010756 metal binding site [ion binding]; metal-binding site 405532010757 Phage lysis protein, holin; Region: Phage_holin; cl04675 405532010758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532010759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532010760 putative substrate translocation pore; other site 405532010761 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532010762 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405532010763 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 405532010764 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 405532010765 THF binding site; other site 405532010766 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 405532010767 substrate binding site [chemical binding]; other site 405532010768 THF binding site; other site 405532010769 zinc-binding site [ion binding]; other site 405532010770 Competence protein J (ComJ); Region: ComJ; pfam11033 405532010771 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 405532010772 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 405532010773 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 405532010774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532010775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532010776 dimer interface [polypeptide binding]; other site 405532010777 phosphorylation site [posttranslational modification] 405532010778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532010779 ATP binding site [chemical binding]; other site 405532010780 Mg2+ binding site [ion binding]; other site 405532010781 G-X-G motif; other site 405532010782 aminotransferase A; Validated; Region: PRK07683 405532010783 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532010784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532010785 homodimer interface [polypeptide binding]; other site 405532010786 catalytic residue [active] 405532010787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405532010788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405532010789 DNA binding site [nucleotide binding] 405532010790 domain linker motif; other site 405532010791 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 405532010792 putative dimerization interface [polypeptide binding]; other site 405532010793 putative ligand binding site [chemical binding]; other site 405532010794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405532010795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532010796 dimer interface [polypeptide binding]; other site 405532010797 conserved gate region; other site 405532010798 putative PBP binding loops; other site 405532010799 ABC-ATPase subunit interface; other site 405532010800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532010801 dimer interface [polypeptide binding]; other site 405532010802 conserved gate region; other site 405532010803 putative PBP binding loops; other site 405532010804 ABC-ATPase subunit interface; other site 405532010805 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 405532010806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 405532010807 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 405532010808 homodimer interface [polypeptide binding]; other site 405532010809 maltodextrin glucosidase; Provisional; Region: PRK10785 405532010810 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 405532010811 active site 405532010812 homodimer interface [polypeptide binding]; other site 405532010813 catalytic site [active] 405532010814 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 405532010815 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405532010816 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405532010817 Ca binding site [ion binding]; other site 405532010818 active site 405532010819 catalytic site [active] 405532010820 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405532010821 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 405532010822 Walker A/P-loop; other site 405532010823 ATP binding site [chemical binding]; other site 405532010824 Q-loop/lid; other site 405532010825 ABC transporter signature motif; other site 405532010826 Walker B; other site 405532010827 D-loop; other site 405532010828 H-loop/switch region; other site 405532010829 TOBE domain; Region: TOBE_2; pfam08402 405532010830 hypothetical protein; Provisional; Region: PRK06720 405532010831 NAD(P) binding site [chemical binding]; other site 405532010832 RDD family; Region: RDD; pfam06271 405532010833 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 405532010834 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 405532010835 Predicted ATPase [General function prediction only]; Region: COG3910 405532010836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532010837 Walker A/P-loop; other site 405532010838 ATP binding site [chemical binding]; other site 405532010839 Q-loop/lid; other site 405532010840 ABC transporter signature motif; other site 405532010841 Walker B; other site 405532010842 D-loop; other site 405532010843 H-loop/switch region; other site 405532010844 putative acyltransferase; Provisional; Region: PRK05790 405532010845 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405532010846 dimer interface [polypeptide binding]; other site 405532010847 active site 405532010848 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405532010849 nudix motif; other site 405532010850 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 405532010851 hypothetical protein; Validated; Region: PRK07668 405532010852 hypothetical protein; Validated; Region: PRK07668 405532010853 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532010854 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405532010855 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 405532010856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532010857 NAD(P) binding site [chemical binding]; other site 405532010858 active site 405532010859 YvrJ protein family; Region: YvrJ; pfam12841 405532010860 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 405532010861 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 405532010862 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 405532010863 Predicted amidohydrolase [General function prediction only]; Region: COG0388 405532010864 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 405532010865 putative active site [active] 405532010866 catalytic triad [active] 405532010867 putative dimer interface [polypeptide binding]; other site 405532010868 transaminase; Reviewed; Region: PRK08068 405532010869 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532010870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532010871 homodimer interface [polypeptide binding]; other site 405532010872 catalytic residue [active] 405532010873 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 405532010874 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 405532010875 dimer interface [polypeptide binding]; other site 405532010876 active site 405532010877 catalytic residue [active] 405532010878 metal binding site [ion binding]; metal-binding site 405532010879 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 405532010880 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 405532010881 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 405532010882 intersubunit interface [polypeptide binding]; other site 405532010883 active site 405532010884 Zn2+ binding site [ion binding]; other site 405532010885 ARD/ARD' family; Region: ARD; pfam03079 405532010886 Cupin domain; Region: Cupin_2; pfam07883 405532010887 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 405532010888 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 405532010889 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405532010890 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405532010891 Beta-lactamase; Region: Beta-lactamase; pfam00144 405532010892 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405532010893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405532010894 metal binding site [ion binding]; metal-binding site 405532010895 active site 405532010896 I-site; other site 405532010897 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405532010898 dimer interface [polypeptide binding]; other site 405532010899 FMN binding site [chemical binding]; other site 405532010900 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 405532010901 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 405532010902 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405532010903 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405532010904 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405532010905 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405532010906 dimerization domain swap beta strand [polypeptide binding]; other site 405532010907 regulatory protein interface [polypeptide binding]; other site 405532010908 active site 405532010909 regulatory phosphorylation site [posttranslational modification]; other site 405532010910 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405532010911 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 405532010912 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405532010913 active site turn [active] 405532010914 phosphorylation site [posttranslational modification] 405532010915 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405532010916 HPr interaction site; other site 405532010917 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405532010918 active site 405532010919 phosphorylation site [posttranslational modification] 405532010920 transcriptional antiterminator BglG; Provisional; Region: PRK09772 405532010921 CAT RNA binding domain; Region: CAT_RBD; smart01061 405532010922 PRD domain; Region: PRD; pfam00874 405532010923 PRD domain; Region: PRD; pfam00874 405532010924 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405532010925 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532010926 active site 405532010927 motif I; other site 405532010928 motif II; other site 405532010929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532010930 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405532010931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532010932 DNA-binding site [nucleotide binding]; DNA binding site 405532010933 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 405532010934 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 405532010935 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 405532010936 active site 405532010937 trimer interface [polypeptide binding]; other site 405532010938 allosteric site; other site 405532010939 active site lid [active] 405532010940 hexamer (dimer of trimers) interface [polypeptide binding]; other site 405532010941 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 405532010942 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 405532010943 active site 405532010944 dimer interface [polypeptide binding]; other site 405532010945 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 405532010946 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532010947 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 405532010948 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 405532010949 Domain of unknown function (DUF309); Region: DUF309; pfam03745 405532010950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532010951 Coenzyme A binding pocket [chemical binding]; other site 405532010952 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 405532010953 active site 405532010954 Predicted secreted protein [Function unknown]; Region: COG4086 405532010955 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 405532010956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 405532010957 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405532010958 active site 405532010959 motif I; other site 405532010960 motif II; other site 405532010961 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 405532010962 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405532010963 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405532010964 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 405532010965 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405532010966 stage V sporulation protein AD; Validated; Region: PRK08304 405532010967 stage V sporulation protein AD; Provisional; Region: PRK12404 405532010968 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405532010969 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 405532010970 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 405532010971 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 405532010972 Na2 binding site [ion binding]; other site 405532010973 putative substrate binding site 1 [chemical binding]; other site 405532010974 Na binding site 1 [ion binding]; other site 405532010975 putative substrate binding site 2 [chemical binding]; other site 405532010976 sporulation sigma factor SigF; Validated; Region: PRK05572 405532010977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532010978 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405532010979 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532010980 DNA binding residues [nucleotide binding] 405532010981 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 405532010982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532010983 ATP binding site [chemical binding]; other site 405532010984 Mg2+ binding site [ion binding]; other site 405532010985 G-X-G motif; other site 405532010986 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 405532010987 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405532010988 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532010989 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405532010990 Predicted transcriptional regulators [Transcription]; Region: COG1725 405532010991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532010992 DNA-binding site [nucleotide binding]; DNA binding site 405532010993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532010994 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532010995 Walker A/P-loop; other site 405532010996 ATP binding site [chemical binding]; other site 405532010997 Q-loop/lid; other site 405532010998 ABC transporter signature motif; other site 405532010999 Walker B; other site 405532011000 D-loop; other site 405532011001 H-loop/switch region; other site 405532011002 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405532011003 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 405532011004 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405532011005 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532011006 MarR family; Region: MarR; pfam01047 405532011007 MarR family; Region: MarR_2; cl17246 405532011008 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 405532011009 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405532011010 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 405532011011 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 405532011012 oligomer interface [polypeptide binding]; other site 405532011013 metal binding site [ion binding]; metal-binding site 405532011014 metal binding site [ion binding]; metal-binding site 405532011015 putative Cl binding site [ion binding]; other site 405532011016 aspartate ring; other site 405532011017 basic sphincter; other site 405532011018 hydrophobic gate; other site 405532011019 periplasmic entrance; other site 405532011020 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 405532011021 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405532011022 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405532011023 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 405532011024 purine nucleoside phosphorylase; Provisional; Region: PRK08202 405532011025 phosphopentomutase; Provisional; Region: PRK05362 405532011026 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 405532011027 YtkA-like; Region: YtkA; pfam13115 405532011028 YtkA-like; Region: YtkA; pfam13115 405532011029 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405532011030 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 405532011031 active site 405532011032 Int/Topo IB signature motif; other site 405532011033 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 405532011034 ferric uptake regulator; Provisional; Region: fur; PRK09462 405532011035 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405532011036 metal binding site 2 [ion binding]; metal-binding site 405532011037 putative DNA binding helix; other site 405532011038 metal binding site 1 [ion binding]; metal-binding site 405532011039 dimer interface [polypeptide binding]; other site 405532011040 structural Zn2+ binding site [ion binding]; other site 405532011041 stage II sporulation protein M; Region: spo_II_M; TIGR02831 405532011042 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532011043 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532011044 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 405532011045 dimer interface [polypeptide binding]; other site 405532011046 ADP-ribose binding site [chemical binding]; other site 405532011047 active site 405532011048 nudix motif; other site 405532011049 metal binding site [ion binding]; metal-binding site 405532011050 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 405532011051 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405532011052 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405532011053 active site 405532011054 catalytic tetrad [active] 405532011055 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405532011056 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405532011057 active site 405532011058 catalytic tetrad [active] 405532011059 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405532011060 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 405532011061 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405532011062 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 405532011063 putative active site [active] 405532011064 putative metal binding site [ion binding]; other site 405532011065 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405532011066 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 405532011067 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532011068 Predicted permease [General function prediction only]; Region: COG2056 405532011069 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 405532011070 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 405532011071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405532011072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405532011073 DNA binding site [nucleotide binding] 405532011074 domain linker motif; other site 405532011075 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 405532011076 dimerization interface [polypeptide binding]; other site 405532011077 ligand binding site [chemical binding]; other site 405532011078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532011079 Coenzyme A binding pocket [chemical binding]; other site 405532011080 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532011081 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 405532011082 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 405532011083 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 405532011084 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 405532011085 catalytic motif [active] 405532011086 Zn binding site [ion binding]; other site 405532011087 RibD C-terminal domain; Region: RibD_C; cl17279 405532011088 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 405532011089 Lumazine binding domain; Region: Lum_binding; pfam00677 405532011090 Lumazine binding domain; Region: Lum_binding; pfam00677 405532011091 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 405532011092 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 405532011093 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 405532011094 dimerization interface [polypeptide binding]; other site 405532011095 active site 405532011096 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 405532011097 homopentamer interface [polypeptide binding]; other site 405532011098 active site 405532011099 biotin synthase; Validated; Region: PRK06256 405532011100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532011101 FeS/SAM binding site; other site 405532011102 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 405532011103 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 405532011104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532011105 S-adenosylmethionine binding site [chemical binding]; other site 405532011106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532011107 Protein of unknown function (DUF452); Region: DUF452; cl01062 405532011108 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405532011109 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405532011110 substrate-cofactor binding pocket; other site 405532011111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532011112 catalytic residue [active] 405532011113 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 405532011114 AAA domain; Region: AAA_26; pfam13500 405532011115 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 405532011116 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405532011117 inhibitor-cofactor binding pocket; inhibition site 405532011118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532011119 catalytic residue [active] 405532011120 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405532011121 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 405532011122 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405532011123 active site 405532011124 metal binding site [ion binding]; metal-binding site 405532011125 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405532011126 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 405532011127 active site 405532011128 catalytic triad [active] 405532011129 oxyanion hole [active] 405532011130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532011131 dimerization interface [polypeptide binding]; other site 405532011132 putative DNA binding site [nucleotide binding]; other site 405532011133 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532011134 putative Zn2+ binding site [ion binding]; other site 405532011135 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 405532011136 ornithine carbamoyltransferase; Provisional; Region: PRK00779 405532011137 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405532011138 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405532011139 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 405532011140 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405532011141 inhibitor-cofactor binding pocket; inhibition site 405532011142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532011143 catalytic residue [active] 405532011144 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 405532011145 nucleotide binding site [chemical binding]; other site 405532011146 N-acetyl-L-glutamate binding site [chemical binding]; other site 405532011147 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 405532011148 heterotetramer interface [polypeptide binding]; other site 405532011149 active site pocket [active] 405532011150 cleavage site 405532011151 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 405532011152 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405532011153 YqzH-like protein; Region: YqzH; pfam14164 405532011154 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 405532011155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532011156 NAD(P) binding site [chemical binding]; other site 405532011157 active site 405532011158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532011159 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 405532011160 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 405532011161 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 405532011162 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 405532011163 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 405532011164 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405532011165 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 405532011166 putative L-serine binding site [chemical binding]; other site 405532011167 ribonuclease Z; Region: RNase_Z; TIGR02651 405532011168 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 405532011169 ykoK leader 405532011170 magnesium-transporting ATPase; Provisional; Region: PRK15122 405532011171 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405532011172 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405532011173 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405532011174 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405532011175 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405532011176 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405532011177 MgtC family; Region: MgtC; pfam02308 405532011178 DNA polymerase IV; Validated; Region: PRK01810 405532011179 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 405532011180 active site 405532011181 DNA binding site [nucleotide binding] 405532011182 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 405532011183 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 405532011184 peptidase T-like protein; Region: PepT-like; TIGR01883 405532011185 metal binding site [ion binding]; metal-binding site 405532011186 putative dimer interface [polypeptide binding]; other site 405532011187 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532011188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532011189 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 405532011190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405532011191 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405532011192 Predicted membrane protein [Function unknown]; Region: COG4129 405532011193 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405532011194 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 405532011195 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405532011196 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405532011197 Walker A/P-loop; other site 405532011198 ATP binding site [chemical binding]; other site 405532011199 Q-loop/lid; other site 405532011200 ABC transporter signature motif; other site 405532011201 Walker B; other site 405532011202 D-loop; other site 405532011203 H-loop/switch region; other site 405532011204 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405532011205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532011206 dimer interface [polypeptide binding]; other site 405532011207 conserved gate region; other site 405532011208 putative PBP binding loops; other site 405532011209 ABC-ATPase subunit interface; other site 405532011210 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405532011211 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405532011212 substrate binding pocket [chemical binding]; other site 405532011213 membrane-bound complex binding site; other site 405532011214 hinge residues; other site 405532011215 Disulphide isomerase; Region: Disulph_isomer; pfam06491 405532011216 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 405532011217 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405532011218 nudix motif; other site 405532011219 Predicted membrane protein [Function unknown]; Region: COG2323 405532011220 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 405532011221 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405532011222 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405532011223 E3 interaction surface; other site 405532011224 lipoyl attachment site [posttranslational modification]; other site 405532011225 e3 binding domain; Region: E3_binding; pfam02817 405532011226 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405532011227 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405532011228 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405532011229 alpha subunit interface [polypeptide binding]; other site 405532011230 TPP binding site [chemical binding]; other site 405532011231 heterodimer interface [polypeptide binding]; other site 405532011232 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405532011233 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 405532011234 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405532011235 tetramer interface [polypeptide binding]; other site 405532011236 TPP-binding site [chemical binding]; other site 405532011237 heterodimer interface [polypeptide binding]; other site 405532011238 phosphorylation loop region [posttranslational modification] 405532011239 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 405532011240 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 405532011241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532011242 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405532011243 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405532011244 nucleotide binding site [chemical binding]; other site 405532011245 Acetokinase family; Region: Acetate_kinase; cl17229 405532011246 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 405532011247 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 405532011248 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 405532011249 NAD binding site [chemical binding]; other site 405532011250 Phe binding site; other site 405532011251 phosphate butyryltransferase; Validated; Region: PRK07742 405532011252 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 405532011253 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532011254 putative active site [active] 405532011255 heme pocket [chemical binding]; other site 405532011256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532011257 putative active site [active] 405532011258 heme pocket [chemical binding]; other site 405532011259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532011260 Walker A motif; other site 405532011261 ATP binding site [chemical binding]; other site 405532011262 Walker B motif; other site 405532011263 arginine finger; other site 405532011264 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405532011265 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 405532011266 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405532011267 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 405532011268 active site 405532011269 catalytic site [active] 405532011270 metal binding site [ion binding]; metal-binding site 405532011271 dimer interface [polypeptide binding]; other site 405532011272 YycC-like protein; Region: YycC; pfam14174 405532011273 hypothetical protein; Provisional; Region: PRK06770 405532011274 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 405532011275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532011276 active site 405532011277 phosphorylation site [posttranslational modification] 405532011278 intermolecular recognition site; other site 405532011279 dimerization interface [polypeptide binding]; other site 405532011280 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 405532011281 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 405532011282 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405532011283 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 405532011284 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 405532011285 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405532011286 Walker A/P-loop; other site 405532011287 ATP binding site [chemical binding]; other site 405532011288 Q-loop/lid; other site 405532011289 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405532011290 ABC transporter signature motif; other site 405532011291 Walker B; other site 405532011292 D-loop; other site 405532011293 H-loop/switch region; other site 405532011294 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 405532011295 arginine repressor; Provisional; Region: PRK04280 405532011296 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 405532011297 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 405532011298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532011299 RNA binding surface [nucleotide binding]; other site 405532011300 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 405532011301 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 405532011302 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 405532011303 TPP-binding site; other site 405532011304 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405532011305 PYR/PP interface [polypeptide binding]; other site 405532011306 dimer interface [polypeptide binding]; other site 405532011307 TPP binding site [chemical binding]; other site 405532011308 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405532011309 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405532011310 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405532011311 substrate binding pocket [chemical binding]; other site 405532011312 chain length determination region; other site 405532011313 substrate-Mg2+ binding site; other site 405532011314 catalytic residues [active] 405532011315 aspartate-rich region 1; other site 405532011316 active site lid residues [active] 405532011317 aspartate-rich region 2; other site 405532011318 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 405532011319 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 405532011320 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 405532011321 generic binding surface II; other site 405532011322 generic binding surface I; other site 405532011323 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 405532011324 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 405532011325 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 405532011326 homodimer interface [polypeptide binding]; other site 405532011327 NADP binding site [chemical binding]; other site 405532011328 substrate binding site [chemical binding]; other site 405532011329 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 405532011330 putative RNA binding site [nucleotide binding]; other site 405532011331 Asp23 family; Region: Asp23; pfam03780 405532011332 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 405532011333 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405532011334 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405532011335 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405532011336 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 405532011337 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405532011338 carboxyltransferase (CT) interaction site; other site 405532011339 biotinylation site [posttranslational modification]; other site 405532011340 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 405532011341 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 405532011342 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 405532011343 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 405532011344 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 405532011345 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 405532011346 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 405532011347 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 405532011348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532011349 Walker A motif; other site 405532011350 ATP binding site [chemical binding]; other site 405532011351 Walker B motif; other site 405532011352 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 405532011353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532011354 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532011355 elongation factor P; Validated; Region: PRK00529 405532011356 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 405532011357 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 405532011358 RNA binding site [nucleotide binding]; other site 405532011359 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 405532011360 RNA binding site [nucleotide binding]; other site 405532011361 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405532011362 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405532011363 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405532011364 active site 405532011365 Dehydroquinase class II; Region: DHquinase_II; pfam01220 405532011366 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 405532011367 trimer interface [polypeptide binding]; other site 405532011368 active site 405532011369 dimer interface [polypeptide binding]; other site 405532011370 Conserved membrane protein YqhR; Region: YqhR; pfam11085 405532011371 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 405532011372 Carbon starvation protein CstA; Region: CstA; pfam02554 405532011373 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 405532011374 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405532011375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532011376 motif II; other site 405532011377 manganese transport transcriptional regulator; Provisional; Region: PRK03902 405532011378 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 405532011379 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 405532011380 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 405532011381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532011382 FeS/SAM binding site; other site 405532011383 Predicted transcriptional regulators [Transcription]; Region: COG1695 405532011384 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405532011385 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405532011386 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405532011387 active site residue [active] 405532011388 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405532011389 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405532011390 DNA binding site [nucleotide binding] 405532011391 domain linker motif; other site 405532011392 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405532011393 putative dimerization interface [polypeptide binding]; other site 405532011394 putative ligand binding site [chemical binding]; other site 405532011395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532011396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532011397 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405532011398 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405532011399 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 405532011400 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405532011401 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405532011402 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405532011403 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 405532011404 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532011405 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532011406 Walker A/P-loop; other site 405532011407 ATP binding site [chemical binding]; other site 405532011408 Q-loop/lid; other site 405532011409 ABC transporter signature motif; other site 405532011410 Walker B; other site 405532011411 D-loop; other site 405532011412 H-loop/switch region; other site 405532011413 Predicted transcriptional regulators [Transcription]; Region: COG1725 405532011414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532011415 DNA-binding site [nucleotide binding]; DNA binding site 405532011416 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 405532011417 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405532011418 tetramer interface [polypeptide binding]; other site 405532011419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532011420 catalytic residue [active] 405532011421 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 405532011422 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405532011423 tetramer interface [polypeptide binding]; other site 405532011424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532011425 catalytic residue [active] 405532011426 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 405532011427 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 405532011428 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 405532011429 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405532011430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532011431 ATP binding site [chemical binding]; other site 405532011432 putative Mg++ binding site [ion binding]; other site 405532011433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532011434 nucleotide binding region [chemical binding]; other site 405532011435 ATP-binding site [chemical binding]; other site 405532011436 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 405532011437 YqzE-like protein; Region: YqzE; pfam14038 405532011438 Shikimate kinase; Region: SKI; pfam01202 405532011439 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 405532011440 ADP binding site [chemical binding]; other site 405532011441 magnesium binding site [ion binding]; other site 405532011442 putative shikimate binding site; other site 405532011443 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 405532011444 ComG operon protein 7; Region: ComGG; pfam14173 405532011445 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 405532011446 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405532011447 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 405532011448 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405532011449 Type II/IV secretion system protein; Region: T2SE; pfam00437 405532011450 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405532011451 Walker A motif; other site 405532011452 ATP binding site [chemical binding]; other site 405532011453 Walker B motif; other site 405532011454 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532011455 putative DNA binding site [nucleotide binding]; other site 405532011456 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 405532011457 putative Zn2+ binding site [ion binding]; other site 405532011458 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 405532011459 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 405532011460 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405532011461 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 405532011462 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 405532011463 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405532011464 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 405532011465 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 405532011466 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405532011467 active site 405532011468 homodimer interface [polypeptide binding]; other site 405532011469 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 405532011470 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 405532011471 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 405532011472 substrate binding pocket [chemical binding]; other site 405532011473 dimer interface [polypeptide binding]; other site 405532011474 inhibitor binding site; inhibition site 405532011475 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 405532011476 B12 binding site [chemical binding]; other site 405532011477 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 405532011478 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 405532011479 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 405532011480 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 405532011481 FAD binding site [chemical binding]; other site 405532011482 cystathionine gamma-synthase; Reviewed; Region: PRK08247 405532011483 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405532011484 homodimer interface [polypeptide binding]; other site 405532011485 substrate-cofactor binding pocket; other site 405532011486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532011487 catalytic residue [active] 405532011488 cystathionine beta-lyase; Provisional; Region: PRK08064 405532011489 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405532011490 homodimer interface [polypeptide binding]; other site 405532011491 substrate-cofactor binding pocket; other site 405532011492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532011493 catalytic residue [active] 405532011494 Isochorismatase family; Region: Isochorismatase; pfam00857 405532011495 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405532011496 catalytic triad [active] 405532011497 conserved cis-peptide bond; other site 405532011498 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532011499 dimerization interface [polypeptide binding]; other site 405532011500 putative DNA binding site [nucleotide binding]; other site 405532011501 putative Zn2+ binding site [ion binding]; other site 405532011502 Uncharacterized conserved protein [Function unknown]; Region: COG1565 405532011503 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405532011504 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 405532011505 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 405532011506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405532011507 nucleotide binding site [chemical binding]; other site 405532011508 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 405532011509 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 405532011510 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 405532011511 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 405532011512 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 405532011513 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 405532011514 active site 405532011515 Substrate binding site; other site 405532011516 Mg++ binding site; other site 405532011517 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405532011518 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 405532011519 active site 405532011520 metal binding site [ion binding]; metal-binding site 405532011521 substrate binding site [chemical binding]; other site 405532011522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405532011523 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532011524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405532011525 Helix-turn-helix domain; Region: HTH_28; pfam13518 405532011526 putative transposase OrfB; Reviewed; Region: PHA02517 405532011527 HTH-like domain; Region: HTH_21; pfam13276 405532011528 Integrase core domain; Region: rve; pfam00665 405532011529 Integrase core domain; Region: rve_2; pfam13333 405532011530 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 405532011531 PhoU domain; Region: PhoU; pfam01895 405532011532 PhoU domain; Region: PhoU; pfam01895 405532011533 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 405532011534 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 405532011535 Walker A/P-loop; other site 405532011536 ATP binding site [chemical binding]; other site 405532011537 Q-loop/lid; other site 405532011538 ABC transporter signature motif; other site 405532011539 Walker B; other site 405532011540 D-loop; other site 405532011541 H-loop/switch region; other site 405532011542 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 405532011543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532011544 dimer interface [polypeptide binding]; other site 405532011545 conserved gate region; other site 405532011546 putative PBP binding loops; other site 405532011547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405532011548 ABC-ATPase subunit interface; other site 405532011549 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405532011550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532011551 dimer interface [polypeptide binding]; other site 405532011552 conserved gate region; other site 405532011553 putative PBP binding loops; other site 405532011554 ABC-ATPase subunit interface; other site 405532011555 PBP superfamily domain; Region: PBP_like_2; cl17296 405532011556 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405532011557 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532011558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532011559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532011560 putative substrate translocation pore; other site 405532011561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532011562 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405532011563 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405532011564 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405532011565 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 405532011566 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 405532011567 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405532011568 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405532011569 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405532011570 metal binding site 2 [ion binding]; metal-binding site 405532011571 putative DNA binding helix; other site 405532011572 metal binding site 1 [ion binding]; metal-binding site 405532011573 dimer interface [polypeptide binding]; other site 405532011574 structural Zn2+ binding site [ion binding]; other site 405532011575 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405532011576 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532011577 ABC-ATPase subunit interface; other site 405532011578 dimer interface [polypeptide binding]; other site 405532011579 putative PBP binding regions; other site 405532011580 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 405532011581 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 405532011582 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532011583 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532011584 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532011585 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 405532011586 endonuclease IV; Provisional; Region: PRK01060 405532011587 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 405532011588 AP (apurinic/apyrimidinic) site pocket; other site 405532011589 DNA interaction; other site 405532011590 Metal-binding active site; metal-binding site 405532011591 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405532011592 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405532011593 ATP binding site [chemical binding]; other site 405532011594 Mg++ binding site [ion binding]; other site 405532011595 motif III; other site 405532011596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532011597 nucleotide binding region [chemical binding]; other site 405532011598 ATP-binding site [chemical binding]; other site 405532011599 YqfQ-like protein; Region: YqfQ; pfam14181 405532011600 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 405532011601 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 405532011602 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405532011603 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405532011604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 405532011605 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405532011606 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405532011607 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 405532011608 Family of unknown function (DUF633); Region: DUF633; pfam04816 405532011609 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405532011610 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405532011611 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 405532011612 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 405532011613 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 405532011614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532011615 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405532011616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532011617 DNA binding residues [nucleotide binding] 405532011618 DNA primase; Validated; Region: dnaG; PRK05667 405532011619 CHC2 zinc finger; Region: zf-CHC2; pfam01807 405532011620 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 405532011621 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 405532011622 active site 405532011623 metal binding site [ion binding]; metal-binding site 405532011624 interdomain interaction site; other site 405532011625 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 405532011626 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 405532011627 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 405532011628 PEP synthetase regulatory protein; Provisional; Region: PRK05339 405532011629 HTH domain; Region: HTH_11; pfam08279 405532011630 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 405532011631 FOG: CBS domain [General function prediction only]; Region: COG0517 405532011632 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 405532011633 Recombination protein O N terminal; Region: RecO_N; pfam11967 405532011634 Recombination protein O C terminal; Region: RecO_C; pfam02565 405532011635 YqzL-like protein; Region: YqzL; pfam14006 405532011636 GTPase Era; Reviewed; Region: era; PRK00089 405532011637 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 405532011638 G1 box; other site 405532011639 GTP/Mg2+ binding site [chemical binding]; other site 405532011640 Switch I region; other site 405532011641 G2 box; other site 405532011642 Switch II region; other site 405532011643 G3 box; other site 405532011644 G4 box; other site 405532011645 G5 box; other site 405532011646 KH domain; Region: KH_2; pfam07650 405532011647 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405532011648 active site 405532011649 catalytic motif [active] 405532011650 Zn binding site [ion binding]; other site 405532011651 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 405532011652 metal-binding heat shock protein; Provisional; Region: PRK00016 405532011653 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 405532011654 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 405532011655 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532011656 Zn2+ binding site [ion binding]; other site 405532011657 Mg2+ binding site [ion binding]; other site 405532011658 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 405532011659 PhoH-like protein; Region: PhoH; pfam02562 405532011660 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 405532011661 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 405532011662 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 405532011663 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 405532011664 Yqey-like protein; Region: YqeY; pfam09424 405532011665 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 405532011666 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 405532011667 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405532011668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532011669 FeS/SAM binding site; other site 405532011670 TRAM domain; Region: TRAM; cl01282 405532011671 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 405532011672 RNA methyltransferase, RsmE family; Region: TIGR00046 405532011673 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 405532011674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532011675 S-adenosylmethionine binding site [chemical binding]; other site 405532011676 chaperone protein DnaJ; Provisional; Region: PRK14280 405532011677 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 405532011678 HSP70 interaction site [polypeptide binding]; other site 405532011679 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 405532011680 substrate binding site [polypeptide binding]; other site 405532011681 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405532011682 Zn binding sites [ion binding]; other site 405532011683 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 405532011684 dimer interface [polypeptide binding]; other site 405532011685 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 405532011686 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 405532011687 nucleotide binding site [chemical binding]; other site 405532011688 NEF interaction site [polypeptide binding]; other site 405532011689 SBD interface [polypeptide binding]; other site 405532011690 GrpE; Region: GrpE; pfam01025 405532011691 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 405532011692 dimer interface [polypeptide binding]; other site 405532011693 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 405532011694 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 405532011695 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 405532011696 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 405532011697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532011698 FeS/SAM binding site; other site 405532011699 HemN C-terminal domain; Region: HemN_C; pfam06969 405532011700 Predicted transcriptional regulators [Transcription]; Region: COG1733 405532011701 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405532011702 GTP-binding protein LepA; Provisional; Region: PRK05433 405532011703 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 405532011704 G1 box; other site 405532011705 putative GEF interaction site [polypeptide binding]; other site 405532011706 GTP/Mg2+ binding site [chemical binding]; other site 405532011707 Switch I region; other site 405532011708 G2 box; other site 405532011709 G3 box; other site 405532011710 Switch II region; other site 405532011711 G4 box; other site 405532011712 G5 box; other site 405532011713 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 405532011714 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 405532011715 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 405532011716 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 405532011717 germination protease; Provisional; Region: PRK02858 405532011718 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 405532011719 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 405532011720 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 405532011721 YqzM-like protein; Region: YqzM; pfam14141 405532011722 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 405532011723 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 405532011724 Competence protein; Region: Competence; pfam03772 405532011725 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532011726 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 405532011727 catalytic motif [active] 405532011728 Zn binding site [ion binding]; other site 405532011729 SLBB domain; Region: SLBB; pfam10531 405532011730 comEA protein; Region: comE; TIGR01259 405532011731 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 405532011732 late competence protein ComER; Validated; Region: PRK07680 405532011733 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 405532011734 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 405532011735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532011736 S-adenosylmethionine binding site [chemical binding]; other site 405532011737 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 405532011738 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 405532011739 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532011740 Zn2+ binding site [ion binding]; other site 405532011741 Mg2+ binding site [ion binding]; other site 405532011742 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 405532011743 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 405532011744 active site 405532011745 (T/H)XGH motif; other site 405532011746 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 405532011747 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 405532011748 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 405532011749 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405532011750 shikimate binding site; other site 405532011751 NAD(P) binding site [chemical binding]; other site 405532011752 GTPase YqeH; Provisional; Region: PRK13796 405532011753 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 405532011754 GTP/Mg2+ binding site [chemical binding]; other site 405532011755 G4 box; other site 405532011756 G5 box; other site 405532011757 G1 box; other site 405532011758 Switch I region; other site 405532011759 G2 box; other site 405532011760 G3 box; other site 405532011761 Switch II region; other site 405532011762 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 405532011763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532011764 active site 405532011765 motif I; other site 405532011766 motif II; other site 405532011767 Sporulation inhibitor A; Region: Sda; pfam08970 405532011768 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 405532011769 sporulation sigma factor SigK; Reviewed; Region: PRK05803 405532011770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532011771 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532011772 DNA binding residues [nucleotide binding] 405532011773 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 405532011774 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405532011775 dimer interface [polypeptide binding]; other site 405532011776 FMN binding site [chemical binding]; other site 405532011777 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405532011778 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405532011779 synthetase active site [active] 405532011780 NTP binding site [chemical binding]; other site 405532011781 metal binding site [ion binding]; metal-binding site 405532011782 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 405532011783 dimer interface [polypeptide binding]; other site 405532011784 Alkaline phosphatase homologues; Region: alkPPc; smart00098 405532011785 active site 405532011786 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405532011787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532011788 Coenzyme A binding pocket [chemical binding]; other site 405532011789 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405532011790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532011791 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 405532011792 catalytic site [active] 405532011793 CHAT domain; Region: CHAT; cl17868 405532011794 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 405532011795 catalytic core [active] 405532011796 translocation protein TolB; Provisional; Region: tolB; PRK04792 405532011797 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405532011798 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 405532011799 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405532011800 putative active site [active] 405532011801 catalytic triad [active] 405532011802 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 405532011803 putative integrin binding motif; other site 405532011804 PA/protease domain interface [polypeptide binding]; other site 405532011805 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405532011806 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 405532011807 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 405532011808 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 405532011809 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 405532011810 cofactor binding site; other site 405532011811 metal binding site [ion binding]; metal-binding site 405532011812 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 405532011813 aromatic arch; other site 405532011814 DCoH dimer interaction site [polypeptide binding]; other site 405532011815 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 405532011816 DCoH tetramer interaction site [polypeptide binding]; other site 405532011817 substrate binding site [chemical binding]; other site 405532011818 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405532011819 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 405532011820 putative metal binding site [ion binding]; other site 405532011821 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405532011822 active site 405532011823 metal binding site [ion binding]; metal-binding site 405532011824 Predicted membrane protein [Function unknown]; Region: COG2259 405532011825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532011826 non-specific DNA binding site [nucleotide binding]; other site 405532011827 salt bridge; other site 405532011828 sequence-specific DNA binding site [nucleotide binding]; other site 405532011829 Cupin domain; Region: Cupin_2; pfam07883 405532011830 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 405532011831 active site 2 [active] 405532011832 active site 1 [active] 405532011833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532011834 Coenzyme A binding pocket [chemical binding]; other site 405532011835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532011836 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532011837 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405532011838 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 405532011839 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405532011840 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405532011841 Walker A/P-loop; other site 405532011842 ATP binding site [chemical binding]; other site 405532011843 Q-loop/lid; other site 405532011844 ABC transporter signature motif; other site 405532011845 Walker B; other site 405532011846 D-loop; other site 405532011847 H-loop/switch region; other site 405532011848 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405532011849 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532011850 ABC-ATPase subunit interface; other site 405532011851 dimer interface [polypeptide binding]; other site 405532011852 putative PBP binding regions; other site 405532011853 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405532011854 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405532011855 intersubunit interface [polypeptide binding]; other site 405532011856 YrhC-like protein; Region: YrhC; pfam14143 405532011857 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 405532011858 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 405532011859 putative catalytic cysteine [active] 405532011860 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 405532011861 putative active site [active] 405532011862 metal binding site [ion binding]; metal-binding site 405532011863 cystathionine beta-lyase; Provisional; Region: PRK07671 405532011864 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405532011865 homodimer interface [polypeptide binding]; other site 405532011866 substrate-cofactor binding pocket; other site 405532011867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532011868 catalytic residue [active] 405532011869 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405532011870 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405532011871 dimer interface [polypeptide binding]; other site 405532011872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532011873 catalytic residue [active] 405532011874 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 405532011875 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405532011876 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405532011877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532011878 S-adenosylmethionine binding site [chemical binding]; other site 405532011879 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 405532011880 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 405532011881 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405532011882 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405532011883 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532011884 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 405532011885 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 405532011886 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 405532011887 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 405532011888 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 405532011889 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 405532011890 ATP-binding site [chemical binding]; other site 405532011891 Sugar specificity; other site 405532011892 Pyrimidine base specificity; other site 405532011893 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405532011894 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405532011895 Peptidase family U32; Region: Peptidase_U32; pfam01136 405532011896 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405532011897 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 405532011898 Peptidase family U32; Region: Peptidase_U32; pfam01136 405532011899 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405532011900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532011901 S-adenosylmethionine binding site [chemical binding]; other site 405532011902 YceG-like family; Region: YceG; pfam02618 405532011903 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 405532011904 dimerization interface [polypeptide binding]; other site 405532011905 hypothetical protein; Provisional; Region: PRK13678 405532011906 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 405532011907 hypothetical protein; Provisional; Region: PRK05473 405532011908 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 405532011909 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 405532011910 motif 1; other site 405532011911 active site 405532011912 motif 2; other site 405532011913 motif 3; other site 405532011914 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405532011915 DHHA1 domain; Region: DHHA1; pfam02272 405532011916 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405532011917 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405532011918 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 405532011919 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 405532011920 AAA domain; Region: AAA_30; pfam13604 405532011921 Family description; Region: UvrD_C_2; pfam13538 405532011922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532011923 TPR motif; other site 405532011924 TPR repeat; Region: TPR_11; pfam13414 405532011925 binding surface 405532011926 TPR repeat; Region: TPR_11; pfam13414 405532011927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532011928 binding surface 405532011929 TPR motif; other site 405532011930 TPR repeat; Region: TPR_11; pfam13414 405532011931 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 405532011932 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 405532011933 Ligand Binding Site [chemical binding]; other site 405532011934 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405532011935 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405532011936 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532011937 catalytic residue [active] 405532011938 Predicted transcriptional regulator [Transcription]; Region: COG1959 405532011939 Transcriptional regulator; Region: Rrf2; pfam02082 405532011940 recombination factor protein RarA; Reviewed; Region: PRK13342 405532011941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532011942 Walker A motif; other site 405532011943 ATP binding site [chemical binding]; other site 405532011944 Walker B motif; other site 405532011945 arginine finger; other site 405532011946 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 405532011947 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405532011948 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405532011949 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 405532011950 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 405532011951 putative ATP binding site [chemical binding]; other site 405532011952 putative substrate interface [chemical binding]; other site 405532011953 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 405532011954 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 405532011955 dimer interface [polypeptide binding]; other site 405532011956 anticodon binding site; other site 405532011957 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405532011958 homodimer interface [polypeptide binding]; other site 405532011959 motif 1; other site 405532011960 active site 405532011961 motif 2; other site 405532011962 GAD domain; Region: GAD; pfam02938 405532011963 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405532011964 motif 3; other site 405532011965 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 405532011966 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405532011967 dimer interface [polypeptide binding]; other site 405532011968 motif 1; other site 405532011969 active site 405532011970 motif 2; other site 405532011971 motif 3; other site 405532011972 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405532011973 anticodon binding site; other site 405532011974 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 405532011975 putative active site [active] 405532011976 dimerization interface [polypeptide binding]; other site 405532011977 putative tRNAtyr binding site [nucleotide binding]; other site 405532011978 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405532011979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532011980 Zn2+ binding site [ion binding]; other site 405532011981 Mg2+ binding site [ion binding]; other site 405532011982 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405532011983 synthetase active site [active] 405532011984 NTP binding site [chemical binding]; other site 405532011985 metal binding site [ion binding]; metal-binding site 405532011986 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405532011987 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 405532011988 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532011989 active site 405532011990 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 405532011991 DHH family; Region: DHH; pfam01368 405532011992 DHHA1 domain; Region: DHHA1; pfam02272 405532011993 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 405532011994 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405532011995 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 405532011996 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 405532011997 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405532011998 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 405532011999 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405532012000 Protein export membrane protein; Region: SecD_SecF; pfam02355 405532012001 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 405532012002 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405532012003 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405532012004 Predicted membrane protein [Function unknown]; Region: COG2323 405532012005 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 405532012006 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 405532012007 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 405532012008 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 405532012009 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 405532012010 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 405532012011 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 405532012012 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 405532012013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532012014 Walker A motif; other site 405532012015 ATP binding site [chemical binding]; other site 405532012016 Walker B motif; other site 405532012017 arginine finger; other site 405532012018 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 405532012019 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 405532012020 RuvA N terminal domain; Region: RuvA_N; pfam01330 405532012021 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 405532012022 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405532012023 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405532012024 putative ligand binding residues [chemical binding]; other site 405532012025 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 405532012026 BofC C-terminal domain; Region: BofC_C; pfam08955 405532012027 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405532012028 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405532012029 quinolinate synthetase; Provisional; Region: PRK09375 405532012030 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 405532012031 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 405532012032 dimerization interface [polypeptide binding]; other site 405532012033 active site 405532012034 L-aspartate oxidase; Provisional; Region: PRK08071 405532012035 L-aspartate oxidase; Provisional; Region: PRK06175 405532012036 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405532012037 cysteine desulfurase; Provisional; Region: PRK02948 405532012038 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405532012039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532012040 catalytic residue [active] 405532012041 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 405532012042 HTH domain; Region: HTH_11; pfam08279 405532012043 3H domain; Region: 3H; pfam02829 405532012044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 405532012045 MOSC domain; Region: MOSC; pfam03473 405532012046 3-alpha domain; Region: 3-alpha; pfam03475 405532012047 prephenate dehydratase; Provisional; Region: PRK11898 405532012048 Prephenate dehydratase; Region: PDT; pfam00800 405532012049 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 405532012050 putative L-Phe binding site [chemical binding]; other site 405532012051 FtsX-like permease family; Region: FtsX; pfam02687 405532012052 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405532012053 FtsX-like permease family; Region: FtsX; pfam02687 405532012054 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405532012055 FtsX-like permease family; Region: FtsX; pfam02687 405532012056 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532012057 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532012058 Walker A/P-loop; other site 405532012059 ATP binding site [chemical binding]; other site 405532012060 Q-loop/lid; other site 405532012061 ABC transporter signature motif; other site 405532012062 Walker B; other site 405532012063 D-loop; other site 405532012064 H-loop/switch region; other site 405532012065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532012066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 405532012067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532012068 ATP binding site [chemical binding]; other site 405532012069 Mg2+ binding site [ion binding]; other site 405532012070 G-X-G motif; other site 405532012071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532012072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532012073 active site 405532012074 phosphorylation site [posttranslational modification] 405532012075 intermolecular recognition site; other site 405532012076 dimerization interface [polypeptide binding]; other site 405532012077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532012078 DNA binding site [nucleotide binding] 405532012079 GTPase CgtA; Reviewed; Region: obgE; PRK12297 405532012080 GTP1/OBG; Region: GTP1_OBG; pfam01018 405532012081 Obg GTPase; Region: Obg; cd01898 405532012082 G1 box; other site 405532012083 GTP/Mg2+ binding site [chemical binding]; other site 405532012084 Switch I region; other site 405532012085 G2 box; other site 405532012086 G3 box; other site 405532012087 Switch II region; other site 405532012088 G4 box; other site 405532012089 G5 box; other site 405532012090 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 405532012091 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 405532012092 hypothetical protein; Provisional; Region: PRK14553 405532012093 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 405532012094 Ribosomal protein L21 leader 405532012095 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 405532012096 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 405532012097 homodimer interface [polypeptide binding]; other site 405532012098 oligonucleotide binding site [chemical binding]; other site 405532012099 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 405532012100 Peptidase family M50; Region: Peptidase_M50; pfam02163 405532012101 active site 405532012102 putative substrate binding region [chemical binding]; other site 405532012103 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405532012104 Peptidase family M23; Region: Peptidase_M23; pfam01551 405532012105 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 405532012106 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 405532012107 Switch I; other site 405532012108 Switch II; other site 405532012109 septum formation inhibitor; Reviewed; Region: minC; PRK00513 405532012110 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 405532012111 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 405532012112 rod shape-determining protein MreC; Provisional; Region: PRK13922 405532012113 rod shape-determining protein MreC; Region: MreC; pfam04085 405532012114 rod shape-determining protein MreB; Provisional; Region: PRK13927 405532012115 MreB and similar proteins; Region: MreB_like; cd10225 405532012116 nucleotide binding site [chemical binding]; other site 405532012117 Mg binding site [ion binding]; other site 405532012118 putative protofilament interaction site [polypeptide binding]; other site 405532012119 RodZ interaction site [polypeptide binding]; other site 405532012120 hypothetical protein; Reviewed; Region: PRK00024 405532012121 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 405532012122 MPN+ (JAMM) motif; other site 405532012123 Zinc-binding site [ion binding]; other site 405532012124 Maf-like protein; Region: Maf; pfam02545 405532012125 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 405532012126 active site 405532012127 dimer interface [polypeptide binding]; other site 405532012128 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 405532012129 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405532012130 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405532012131 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 405532012132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405532012133 active site 405532012134 HIGH motif; other site 405532012135 nucleotide binding site [chemical binding]; other site 405532012136 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405532012137 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 405532012138 active site 405532012139 KMSKS motif; other site 405532012140 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 405532012141 tRNA binding surface [nucleotide binding]; other site 405532012142 anticodon binding site; other site 405532012143 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 405532012144 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 405532012145 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 405532012146 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 405532012147 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405532012148 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 405532012149 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405532012150 inhibitor-cofactor binding pocket; inhibition site 405532012151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532012152 catalytic residue [active] 405532012153 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 405532012154 dimer interface [polypeptide binding]; other site 405532012155 active site 405532012156 Schiff base residues; other site 405532012157 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 405532012158 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 405532012159 active site 405532012160 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 405532012161 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 405532012162 domain interfaces; other site 405532012163 active site 405532012164 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 405532012165 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 405532012166 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 405532012167 tRNA; other site 405532012168 putative tRNA binding site [nucleotide binding]; other site 405532012169 putative NADP binding site [chemical binding]; other site 405532012170 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 405532012171 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405532012172 MarR family; Region: MarR; pfam01047 405532012173 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 405532012174 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 405532012175 G1 box; other site 405532012176 GTP/Mg2+ binding site [chemical binding]; other site 405532012177 Switch I region; other site 405532012178 G2 box; other site 405532012179 G3 box; other site 405532012180 Switch II region; other site 405532012181 G4 box; other site 405532012182 G5 box; other site 405532012183 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 405532012184 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405532012185 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405532012186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532012187 Walker A motif; other site 405532012188 ATP binding site [chemical binding]; other site 405532012189 Walker B motif; other site 405532012190 arginine finger; other site 405532012191 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405532012192 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 405532012193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532012194 Walker A motif; other site 405532012195 ATP binding site [chemical binding]; other site 405532012196 Walker B motif; other site 405532012197 arginine finger; other site 405532012198 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405532012199 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 405532012200 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 405532012201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532012202 Walker A motif; other site 405532012203 ATP binding site [chemical binding]; other site 405532012204 Walker B motif; other site 405532012205 arginine finger; other site 405532012206 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405532012207 trigger factor; Provisional; Region: tig; PRK01490 405532012208 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405532012209 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 405532012210 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 405532012211 pentamer interface [polypeptide binding]; other site 405532012212 dodecaamer interface [polypeptide binding]; other site 405532012213 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 405532012214 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 405532012215 active site 405532012216 metal binding site [ion binding]; metal-binding site 405532012217 homotetramer interface [polypeptide binding]; other site 405532012218 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 405532012219 active site 405532012220 dimerization interface [polypeptide binding]; other site 405532012221 ribonuclease PH; Reviewed; Region: rph; PRK00173 405532012222 Ribonuclease PH; Region: RNase_PH_bact; cd11362 405532012223 hexamer interface [polypeptide binding]; other site 405532012224 active site 405532012225 Sporulation and spore germination; Region: Germane; pfam10646 405532012226 Spore germination protein [General function prediction only]; Region: COG5401 405532012227 Sporulation and spore germination; Region: Germane; pfam10646 405532012228 glutamate racemase; Provisional; Region: PRK00865 405532012229 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405532012230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532012231 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405532012232 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 405532012233 potential catalytic triad [active] 405532012234 conserved cys residue [active] 405532012235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532012236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532012237 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 405532012238 intracellular protease, PfpI family; Region: PfpI; TIGR01382 405532012239 potential catalytic triad [active] 405532012240 conserved cys residue [active] 405532012241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405532012242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405532012243 DNA binding residues [nucleotide binding] 405532012244 dimerization interface [polypeptide binding]; other site 405532012245 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405532012246 putative deaminase; Validated; Region: PRK06846 405532012247 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 405532012248 active site 405532012249 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 405532012250 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532012251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532012252 non-specific DNA binding site [nucleotide binding]; other site 405532012253 salt bridge; other site 405532012254 sequence-specific DNA binding site [nucleotide binding]; other site 405532012255 Cupin domain; Region: Cupin_2; pfam07883 405532012256 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 405532012257 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 405532012258 amphipathic channel; other site 405532012259 Asn-Pro-Ala signature motifs; other site 405532012260 Predicted transcriptional regulator [Transcription]; Region: COG1959 405532012261 Transcriptional regulator; Region: Rrf2; pfam02082 405532012262 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 405532012263 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 405532012264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532012265 Walker A/P-loop; other site 405532012266 ATP binding site [chemical binding]; other site 405532012267 Q-loop/lid; other site 405532012268 ABC transporter signature motif; other site 405532012269 Walker B; other site 405532012270 D-loop; other site 405532012271 H-loop/switch region; other site 405532012272 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 405532012273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532012274 active site 405532012275 motif I; other site 405532012276 motif II; other site 405532012277 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 405532012278 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 405532012279 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405532012280 ligand binding site [chemical binding]; other site 405532012281 flagellar motor protein MotA; Validated; Region: PRK08124 405532012282 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 405532012283 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405532012284 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405532012285 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405532012286 active site 405532012287 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 405532012288 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 405532012289 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405532012290 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 405532012291 L-aspartate oxidase; Provisional; Region: PRK06175 405532012292 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405532012293 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 405532012294 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 405532012295 putative Iron-sulfur protein interface [polypeptide binding]; other site 405532012296 proximal heme binding site [chemical binding]; other site 405532012297 distal heme binding site [chemical binding]; other site 405532012298 putative dimer interface [polypeptide binding]; other site 405532012299 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 405532012300 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 405532012301 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405532012302 GIY-YIG motif/motif A; other site 405532012303 active site 405532012304 catalytic site [active] 405532012305 putative DNA binding site [nucleotide binding]; other site 405532012306 metal binding site [ion binding]; metal-binding site 405532012307 UvrB/uvrC motif; Region: UVR; pfam02151 405532012308 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 405532012309 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405532012310 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405532012311 catalytic residues [active] 405532012312 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 405532012313 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 405532012314 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 405532012315 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 405532012316 Ligand binding site [chemical binding]; other site 405532012317 Electron transfer flavoprotein domain; Region: ETF; pfam01012 405532012318 enoyl-CoA hydratase; Provisional; Region: PRK07658 405532012319 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405532012320 substrate binding site [chemical binding]; other site 405532012321 oxyanion hole (OAH) forming residues; other site 405532012322 trimer interface [polypeptide binding]; other site 405532012323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 405532012324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532012325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532012326 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 405532012327 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 405532012328 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 405532012329 acyl-activating enzyme (AAE) consensus motif; other site 405532012330 putative AMP binding site [chemical binding]; other site 405532012331 putative active site [active] 405532012332 putative CoA binding site [chemical binding]; other site 405532012333 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 405532012334 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405532012335 siderophore binding site; other site 405532012336 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405532012337 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532012338 ABC-ATPase subunit interface; other site 405532012339 dimer interface [polypeptide binding]; other site 405532012340 putative PBP binding regions; other site 405532012341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532012342 ABC-ATPase subunit interface; other site 405532012343 dimer interface [polypeptide binding]; other site 405532012344 putative PBP binding regions; other site 405532012345 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 405532012346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532012347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532012348 DNA binding residues [nucleotide binding] 405532012349 DinB family; Region: DinB; pfam05163 405532012350 DinB superfamily; Region: DinB_2; pfam12867 405532012351 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405532012352 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405532012353 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405532012354 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532012355 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405532012356 Walker A/P-loop; other site 405532012357 ATP binding site [chemical binding]; other site 405532012358 Q-loop/lid; other site 405532012359 ABC transporter signature motif; other site 405532012360 Walker B; other site 405532012361 D-loop; other site 405532012362 H-loop/switch region; other site 405532012363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532012364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532012365 dimer interface [polypeptide binding]; other site 405532012366 phosphorylation site [posttranslational modification] 405532012367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532012368 ATP binding site [chemical binding]; other site 405532012369 Mg2+ binding site [ion binding]; other site 405532012370 G-X-G motif; other site 405532012371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532012372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532012373 active site 405532012374 phosphorylation site [posttranslational modification] 405532012375 intermolecular recognition site; other site 405532012376 dimerization interface [polypeptide binding]; other site 405532012377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532012378 DNA binding site [nucleotide binding] 405532012379 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 405532012380 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 405532012381 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 405532012382 putative RNA binding site [nucleotide binding]; other site 405532012383 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 405532012384 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 405532012385 active site 405532012386 catalytic site [active] 405532012387 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405532012388 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405532012389 Walker A/P-loop; other site 405532012390 ATP binding site [chemical binding]; other site 405532012391 Q-loop/lid; other site 405532012392 ABC transporter signature motif; other site 405532012393 Walker B; other site 405532012394 D-loop; other site 405532012395 H-loop/switch region; other site 405532012396 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405532012397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532012398 ABC-ATPase subunit interface; other site 405532012399 dimer interface [polypeptide binding]; other site 405532012400 putative PBP binding regions; other site 405532012401 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 405532012402 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405532012403 intersubunit interface [polypeptide binding]; other site 405532012404 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405532012405 heme-binding site [chemical binding]; other site 405532012406 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405532012407 heme-binding site [chemical binding]; other site 405532012408 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405532012409 heme-binding site [chemical binding]; other site 405532012410 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405532012411 heme-binding site [chemical binding]; other site 405532012412 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405532012413 heme-binding site [chemical binding]; other site 405532012414 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405532012415 heme-binding site [chemical binding]; other site 405532012416 heme uptake protein IsdC; Region: IsdC; TIGR03656 405532012417 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405532012418 heme-binding site [chemical binding]; other site 405532012419 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 405532012420 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405532012421 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405532012422 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532012423 RNA binding surface [nucleotide binding]; other site 405532012424 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 405532012425 probable active site [active] 405532012426 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 405532012427 MutS domain III; Region: MutS_III; pfam05192 405532012428 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 405532012429 Walker A/P-loop; other site 405532012430 ATP binding site [chemical binding]; other site 405532012431 Q-loop/lid; other site 405532012432 ABC transporter signature motif; other site 405532012433 Walker B; other site 405532012434 D-loop; other site 405532012435 H-loop/switch region; other site 405532012436 Smr domain; Region: Smr; pfam01713 405532012437 hypothetical protein; Provisional; Region: PRK08609 405532012438 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 405532012439 active site 405532012440 primer binding site [nucleotide binding]; other site 405532012441 NTP binding site [chemical binding]; other site 405532012442 metal binding triad [ion binding]; metal-binding site 405532012443 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 405532012444 active site 405532012445 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 405532012446 Colicin V production protein; Region: Colicin_V; pfam02674 405532012447 cell division protein ZapA; Provisional; Region: PRK14126 405532012448 ribonuclease HIII; Provisional; Region: PRK00996 405532012449 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 405532012450 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 405532012451 RNA/DNA hybrid binding site [nucleotide binding]; other site 405532012452 active site 405532012453 Transposase IS200 like; Region: Y1_Tnp; pfam01797 405532012454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405532012455 Probable transposase; Region: OrfB_IS605; pfam01385 405532012456 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405532012457 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 405532012458 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 405532012459 putative dimer interface [polypeptide binding]; other site 405532012460 putative anticodon binding site; other site 405532012461 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405532012462 homodimer interface [polypeptide binding]; other site 405532012463 motif 1; other site 405532012464 motif 2; other site 405532012465 active site 405532012466 motif 3; other site 405532012467 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 405532012468 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405532012469 putative tRNA-binding site [nucleotide binding]; other site 405532012470 B3/4 domain; Region: B3_4; pfam03483 405532012471 tRNA synthetase B5 domain; Region: B5; smart00874 405532012472 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 405532012473 dimer interface [polypeptide binding]; other site 405532012474 motif 1; other site 405532012475 motif 3; other site 405532012476 motif 2; other site 405532012477 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 405532012478 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 405532012479 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 405532012480 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 405532012481 dimer interface [polypeptide binding]; other site 405532012482 motif 1; other site 405532012483 active site 405532012484 motif 2; other site 405532012485 motif 3; other site 405532012486 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 405532012487 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 405532012488 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405532012489 Small, acid-soluble spore protein I; Region: SSPI; cl07940 405532012490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532012491 Zn2+ binding site [ion binding]; other site 405532012492 Mg2+ binding site [ion binding]; other site 405532012493 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405532012494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532012495 putative substrate translocation pore; other site 405532012496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532012497 HlyD family secretion protein; Region: HlyD_3; pfam13437 405532012498 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 405532012499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532012500 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405532012501 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405532012502 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 405532012503 oligomer interface [polypeptide binding]; other site 405532012504 active site 405532012505 metal binding site [ion binding]; metal-binding site 405532012506 dUTPase; Region: dUTPase_2; pfam08761 405532012507 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 405532012508 active site 405532012509 homodimer interface [polypeptide binding]; other site 405532012510 metal binding site [ion binding]; metal-binding site 405532012511 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 405532012512 23S rRNA binding site [nucleotide binding]; other site 405532012513 L21 binding site [polypeptide binding]; other site 405532012514 L13 binding site [polypeptide binding]; other site 405532012515 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 405532012516 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 405532012517 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 405532012518 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 405532012519 Ribosomal protein L20 leader 405532012520 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 405532012521 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405532012522 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405532012523 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405532012524 active site 405532012525 dimer interface [polypeptide binding]; other site 405532012526 motif 1; other site 405532012527 motif 2; other site 405532012528 motif 3; other site 405532012529 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405532012530 anticodon binding site; other site 405532012531 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 405532012532 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 405532012533 primosomal protein DnaI; Reviewed; Region: PRK08939 405532012534 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 405532012535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532012536 Walker A motif; other site 405532012537 ATP binding site [chemical binding]; other site 405532012538 Walker B motif; other site 405532012539 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 405532012540 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405532012541 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 405532012542 ATP cone domain; Region: ATP-cone; pfam03477 405532012543 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 405532012544 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 405532012545 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 405532012546 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405532012547 dephospho-CoA kinase; Region: TIGR00152 405532012548 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 405532012549 CoA-binding site [chemical binding]; other site 405532012550 ATP-binding [chemical binding]; other site 405532012551 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 405532012552 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 405532012553 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 405532012554 DNA binding site [nucleotide binding] 405532012555 catalytic residue [active] 405532012556 H2TH interface [polypeptide binding]; other site 405532012557 putative catalytic residues [active] 405532012558 turnover-facilitating residue; other site 405532012559 intercalation triad [nucleotide binding]; other site 405532012560 8OG recognition residue [nucleotide binding]; other site 405532012561 putative reading head residues; other site 405532012562 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 405532012563 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405532012564 DNA polymerase I; Provisional; Region: PRK05755 405532012565 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405532012566 active site 405532012567 metal binding site 1 [ion binding]; metal-binding site 405532012568 putative 5' ssDNA interaction site; other site 405532012569 metal binding site 3; metal-binding site 405532012570 metal binding site 2 [ion binding]; metal-binding site 405532012571 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405532012572 putative DNA binding site [nucleotide binding]; other site 405532012573 putative metal binding site [ion binding]; other site 405532012574 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 405532012575 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 405532012576 active site 405532012577 DNA binding site [nucleotide binding] 405532012578 catalytic site [active] 405532012579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532012580 dimerization interface [polypeptide binding]; other site 405532012581 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405532012582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532012583 putative active site [active] 405532012584 heme pocket [chemical binding]; other site 405532012585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532012586 dimer interface [polypeptide binding]; other site 405532012587 phosphorylation site [posttranslational modification] 405532012588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532012589 ATP binding site [chemical binding]; other site 405532012590 Mg2+ binding site [ion binding]; other site 405532012591 G-X-G motif; other site 405532012592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532012593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532012594 active site 405532012595 phosphorylation site [posttranslational modification] 405532012596 intermolecular recognition site; other site 405532012597 dimerization interface [polypeptide binding]; other site 405532012598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532012599 DNA binding site [nucleotide binding] 405532012600 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 405532012601 active site 2 [active] 405532012602 active site 1 [active] 405532012603 malate dehydrogenase; Reviewed; Region: PRK06223 405532012604 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 405532012605 NAD(P) binding site [chemical binding]; other site 405532012606 dimer interface [polypeptide binding]; other site 405532012607 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405532012608 substrate binding site [chemical binding]; other site 405532012609 isocitrate dehydrogenase; Reviewed; Region: PRK07006 405532012610 isocitrate dehydrogenase; Validated; Region: PRK07362 405532012611 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 405532012612 dimer interface [polypeptide binding]; other site 405532012613 Citrate synthase; Region: Citrate_synt; pfam00285 405532012614 active site 405532012615 citrylCoA binding site [chemical binding]; other site 405532012616 oxalacetate/citrate binding site [chemical binding]; other site 405532012617 coenzyme A binding site [chemical binding]; other site 405532012618 catalytic triad [active] 405532012619 Protein of unknown function (DUF441); Region: DUF441; pfam04284 405532012620 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 405532012621 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405532012622 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 405532012623 pyruvate kinase; Provisional; Region: PRK06354 405532012624 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 405532012625 domain interfaces; other site 405532012626 active site 405532012627 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 405532012628 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 405532012629 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 405532012630 active site 405532012631 ADP/pyrophosphate binding site [chemical binding]; other site 405532012632 dimerization interface [polypeptide binding]; other site 405532012633 allosteric effector site; other site 405532012634 fructose-1,6-bisphosphate binding site; other site 405532012635 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 405532012636 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 405532012637 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 405532012638 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405532012639 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 405532012640 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405532012641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532012642 DNA-binding site [nucleotide binding]; DNA binding site 405532012643 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 405532012644 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405532012645 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 405532012646 putative NAD(P) binding site [chemical binding]; other site 405532012647 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 405532012648 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405532012649 active site 405532012650 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 405532012651 generic binding surface II; other site 405532012652 generic binding surface I; other site 405532012653 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 405532012654 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 405532012655 DHH family; Region: DHH; pfam01368 405532012656 DHHA1 domain; Region: DHHA1; pfam02272 405532012657 YtpI-like protein; Region: YtpI; pfam14007 405532012658 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 405532012659 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 405532012660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532012661 DNA-binding site [nucleotide binding]; DNA binding site 405532012662 DRTGG domain; Region: DRTGG; pfam07085 405532012663 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 405532012664 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 405532012665 active site 2 [active] 405532012666 active site 1 [active] 405532012667 metal-dependent hydrolase; Provisional; Region: PRK00685 405532012668 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405532012669 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405532012670 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405532012671 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405532012672 active site 405532012673 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 405532012674 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405532012675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532012676 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532012677 Coenzyme A binding pocket [chemical binding]; other site 405532012678 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 405532012679 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 405532012680 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 405532012681 hexamer interface [polypeptide binding]; other site 405532012682 ligand binding site [chemical binding]; other site 405532012683 putative active site [active] 405532012684 NAD(P) binding site [chemical binding]; other site 405532012685 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 405532012686 classical (c) SDRs; Region: SDR_c; cd05233 405532012687 NAD(P) binding site [chemical binding]; other site 405532012688 active site 405532012689 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405532012690 Ligand Binding Site [chemical binding]; other site 405532012691 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 405532012692 argininosuccinate lyase; Provisional; Region: PRK00855 405532012693 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 405532012694 active sites [active] 405532012695 tetramer interface [polypeptide binding]; other site 405532012696 argininosuccinate synthase; Provisional; Region: PRK13820 405532012697 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 405532012698 ANP binding site [chemical binding]; other site 405532012699 Substrate Binding Site II [chemical binding]; other site 405532012700 Substrate Binding Site I [chemical binding]; other site 405532012701 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532012702 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532012703 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532012704 EcsC protein family; Region: EcsC; pfam12787 405532012705 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 405532012706 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405532012707 nudix motif; other site 405532012708 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 405532012709 propionate/acetate kinase; Provisional; Region: PRK12379 405532012710 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 405532012711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532012712 S-adenosylmethionine binding site [chemical binding]; other site 405532012713 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 405532012714 dimer interface [polypeptide binding]; other site 405532012715 catalytic triad [active] 405532012716 peroxidatic and resolving cysteines [active] 405532012717 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405532012718 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 405532012719 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 405532012720 ATP-NAD kinase; Region: NAD_kinase; pfam01513 405532012721 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 405532012722 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 405532012723 active site 405532012724 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532012725 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405532012726 dimer interface [polypeptide binding]; other site 405532012727 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 405532012728 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 405532012729 active site 405532012730 acyl-activating enzyme (AAE) consensus motif; other site 405532012731 putative CoA binding site [chemical binding]; other site 405532012732 AMP binding site [chemical binding]; other site 405532012733 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405532012734 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 405532012735 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 405532012736 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 405532012737 Ligand Binding Site [chemical binding]; other site 405532012738 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405532012739 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405532012740 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532012741 catalytic residue [active] 405532012742 septation ring formation regulator EzrA; Provisional; Region: PRK04778 405532012743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532012744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532012745 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405532012746 dimerization interface [polypeptide binding]; other site 405532012747 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532012748 EamA-like transporter family; Region: EamA; pfam00892 405532012749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532012750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532012751 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 405532012752 GAF domain; Region: GAF_2; pfam13185 405532012753 methionine gamma-lyase; Provisional; Region: PRK06767 405532012754 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405532012755 homodimer interface [polypeptide binding]; other site 405532012756 substrate-cofactor binding pocket; other site 405532012757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532012758 catalytic residue [active] 405532012759 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 405532012760 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 405532012761 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532012762 RNA binding surface [nucleotide binding]; other site 405532012763 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 405532012764 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 405532012765 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 405532012766 active site 405532012767 HIGH motif; other site 405532012768 dimer interface [polypeptide binding]; other site 405532012769 KMSKS motif; other site 405532012770 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532012771 RNA binding surface [nucleotide binding]; other site 405532012772 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 405532012773 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 405532012774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532012775 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532012776 DNA binding residues [nucleotide binding] 405532012777 maltose O-acetyltransferase; Provisional; Region: PRK10092 405532012778 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 405532012779 active site 405532012780 substrate binding site [chemical binding]; other site 405532012781 trimer interface [polypeptide binding]; other site 405532012782 CoA binding site [chemical binding]; other site 405532012783 acetyl-CoA synthetase; Provisional; Region: PRK04319 405532012784 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 405532012785 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 405532012786 active site 405532012787 acyl-activating enzyme (AAE) consensus motif; other site 405532012788 putative CoA binding site [chemical binding]; other site 405532012789 AMP binding site [chemical binding]; other site 405532012790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532012791 Coenzyme A binding pocket [chemical binding]; other site 405532012792 FOG: CBS domain [General function prediction only]; Region: COG0517 405532012793 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 405532012794 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 405532012795 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 405532012796 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 405532012797 active site 405532012798 Zn binding site [ion binding]; other site 405532012799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532012800 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532012801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532012802 active site 405532012803 phosphorylation site [posttranslational modification] 405532012804 intermolecular recognition site; other site 405532012805 dimerization interface [polypeptide binding]; other site 405532012806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532012807 DNA binding site [nucleotide binding] 405532012808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532012809 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532012810 dimerization interface [polypeptide binding]; other site 405532012811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532012812 dimer interface [polypeptide binding]; other site 405532012813 phosphorylation site [posttranslational modification] 405532012814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532012815 ATP binding site [chemical binding]; other site 405532012816 Mg2+ binding site [ion binding]; other site 405532012817 G-X-G motif; other site 405532012818 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 405532012819 Ankyrin repeat; Region: Ank; pfam00023 405532012820 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405532012821 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405532012822 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 405532012823 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405532012824 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405532012825 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 405532012826 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 405532012827 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 405532012828 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 405532012829 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 405532012830 catabolite control protein A; Region: ccpA; TIGR01481 405532012831 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405532012832 DNA binding site [nucleotide binding] 405532012833 domain linker motif; other site 405532012834 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 405532012835 dimerization interface [polypeptide binding]; other site 405532012836 effector binding site; other site 405532012837 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 405532012838 Chorismate mutase type II; Region: CM_2; cl00693 405532012839 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 405532012840 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 405532012841 putative dimer interface [polypeptide binding]; other site 405532012842 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 405532012843 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 405532012844 putative dimer interface [polypeptide binding]; other site 405532012845 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 405532012846 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 405532012847 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405532012848 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405532012849 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405532012850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532012851 Coenzyme A binding pocket [chemical binding]; other site 405532012852 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532012853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532012854 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 405532012855 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405532012856 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405532012857 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405532012858 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 405532012859 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 405532012860 active site 405532012861 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405532012862 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405532012863 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405532012864 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405532012865 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405532012866 active site 405532012867 metal binding site [ion binding]; metal-binding site 405532012868 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405532012869 putative tRNA-binding site [nucleotide binding]; other site 405532012870 hypothetical protein; Provisional; Region: PRK13668 405532012871 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405532012872 catalytic residues [active] 405532012873 NTPase; Reviewed; Region: PRK03114 405532012874 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405532012875 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 405532012876 oligomer interface [polypeptide binding]; other site 405532012877 active site 405532012878 metal binding site [ion binding]; metal-binding site 405532012879 Predicted small secreted protein [Function unknown]; Region: COG5584 405532012880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532012881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532012882 S-adenosylmethionine binding site [chemical binding]; other site 405532012883 YtzH-like protein; Region: YtzH; pfam14165 405532012884 Phosphotransferase enzyme family; Region: APH; pfam01636 405532012885 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405532012886 active site 405532012887 substrate binding site [chemical binding]; other site 405532012888 ATP binding site [chemical binding]; other site 405532012889 pullulanase, type I; Region: pulA_typeI; TIGR02104 405532012890 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 405532012891 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 405532012892 Ca binding site [ion binding]; other site 405532012893 active site 405532012894 catalytic site [active] 405532012895 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 405532012896 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405532012897 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405532012898 dipeptidase PepV; Reviewed; Region: PRK07318 405532012899 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 405532012900 active site 405532012901 metal binding site [ion binding]; metal-binding site 405532012902 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405532012903 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405532012904 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532012905 RNA binding surface [nucleotide binding]; other site 405532012906 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 405532012907 active site 405532012908 uracil binding [chemical binding]; other site 405532012909 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405532012910 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405532012911 HI0933-like protein; Region: HI0933_like; pfam03486 405532012912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532012913 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405532012914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532012915 putative substrate translocation pore; other site 405532012916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532012917 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532012918 dimerization interface [polypeptide binding]; other site 405532012919 putative DNA binding site [nucleotide binding]; other site 405532012920 putative Zn2+ binding site [ion binding]; other site 405532012921 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 405532012922 putative hydrophobic ligand binding site [chemical binding]; other site 405532012923 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 405532012924 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 405532012925 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 405532012926 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 405532012927 glucose-1-dehydrogenase; Provisional; Region: PRK08936 405532012928 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 405532012929 NAD binding site [chemical binding]; other site 405532012930 homodimer interface [polypeptide binding]; other site 405532012931 active site 405532012932 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 405532012933 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 405532012934 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405532012935 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405532012936 MoaE interaction surface [polypeptide binding]; other site 405532012937 MoeB interaction surface [polypeptide binding]; other site 405532012938 thiocarboxylated glycine; other site 405532012939 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405532012940 MoaE homodimer interface [polypeptide binding]; other site 405532012941 MoaD interaction [polypeptide binding]; other site 405532012942 active site residues [active] 405532012943 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 405532012944 Walker A motif; other site 405532012945 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405532012946 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405532012947 dimer interface [polypeptide binding]; other site 405532012948 putative functional site; other site 405532012949 putative MPT binding site; other site 405532012950 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 405532012951 trimer interface [polypeptide binding]; other site 405532012952 dimer interface [polypeptide binding]; other site 405532012953 putative active site [active] 405532012954 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405532012955 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405532012956 ATP binding site [chemical binding]; other site 405532012957 substrate interface [chemical binding]; other site 405532012958 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 405532012959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532012960 FeS/SAM binding site; other site 405532012961 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405532012962 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405532012963 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405532012964 active site residue [active] 405532012965 homoserine O-acetyltransferase; Provisional; Region: PRK06765 405532012966 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405532012967 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405532012968 Spore germination protein; Region: Spore_permease; pfam03845 405532012969 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405532012970 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405532012971 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 405532012972 putative nucleotide binding site [chemical binding]; other site 405532012973 putative metal binding site [ion binding]; other site 405532012974 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 405532012975 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405532012976 HIGH motif; other site 405532012977 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405532012978 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405532012979 active site 405532012980 KMSKS motif; other site 405532012981 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 405532012982 tRNA binding surface [nucleotide binding]; other site 405532012983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532012984 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532012985 putative substrate translocation pore; other site 405532012986 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405532012987 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405532012988 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 405532012989 TrkA-C domain; Region: TrkA_C; pfam02080 405532012990 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405532012991 Int/Topo IB signature motif; other site 405532012992 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405532012993 FtsX-like permease family; Region: FtsX; pfam02687 405532012994 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532012995 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532012996 Walker A/P-loop; other site 405532012997 ATP binding site [chemical binding]; other site 405532012998 Q-loop/lid; other site 405532012999 ABC transporter signature motif; other site 405532013000 Walker B; other site 405532013001 D-loop; other site 405532013002 H-loop/switch region; other site 405532013003 Predicted membrane protein [Function unknown]; Region: COG2311 405532013004 Protein of unknown function (DUF418); Region: DUF418; cl12135 405532013005 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405532013006 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 405532013007 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 405532013008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532013009 FeS/SAM binding site; other site 405532013010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532013011 S-adenosylmethionine binding site [chemical binding]; other site 405532013012 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 405532013013 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532013014 Walker A/P-loop; other site 405532013015 ATP binding site [chemical binding]; other site 405532013016 Q-loop/lid; other site 405532013017 ABC transporter signature motif; other site 405532013018 Walker B; other site 405532013019 D-loop; other site 405532013020 H-loop/switch region; other site 405532013021 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 405532013022 aspartate racemase; Region: asp_race; TIGR00035 405532013023 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 405532013024 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 405532013025 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 405532013026 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 405532013027 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405532013028 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532013029 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405532013030 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 405532013031 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 405532013032 trimer interface [polypeptide binding]; other site 405532013033 putative metal binding site [ion binding]; other site 405532013034 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 405532013035 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405532013036 active site 405532013037 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405532013038 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 405532013039 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 405532013040 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 405532013041 GTP binding site; other site 405532013042 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 405532013043 MPT binding site; other site 405532013044 trimer interface [polypeptide binding]; other site 405532013045 S-adenosylmethionine synthetase; Validated; Region: PRK05250 405532013046 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 405532013047 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 405532013048 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 405532013049 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 405532013050 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 405532013051 active site 405532013052 substrate-binding site [chemical binding]; other site 405532013053 metal-binding site [ion binding] 405532013054 ATP binding site [chemical binding]; other site 405532013055 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405532013056 EamA-like transporter family; Region: EamA; pfam00892 405532013057 EamA-like transporter family; Region: EamA; pfam00892 405532013058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 405532013059 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405532013060 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405532013061 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 405532013062 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 405532013063 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405532013064 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405532013065 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405532013066 sensor protein ZraS; Provisional; Region: PRK10364 405532013067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532013068 ATP binding site [chemical binding]; other site 405532013069 Mg2+ binding site [ion binding]; other site 405532013070 G-X-G motif; other site 405532013071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532013072 dimer interface [polypeptide binding]; other site 405532013073 phosphorylation site [posttranslational modification] 405532013074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532013075 ATP binding site [chemical binding]; other site 405532013076 Mg2+ binding site [ion binding]; other site 405532013077 G-X-G motif; other site 405532013078 hydroperoxidase II; Provisional; Region: katE; PRK11249 405532013079 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 405532013080 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405532013081 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405532013082 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 405532013083 Sulfatase; Region: Sulfatase; pfam00884 405532013084 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405532013085 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 405532013086 NMT1-like family; Region: NMT1_2; pfam13379 405532013087 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405532013088 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405532013089 Walker A/P-loop; other site 405532013090 ATP binding site [chemical binding]; other site 405532013091 Q-loop/lid; other site 405532013092 ABC transporter signature motif; other site 405532013093 Walker B; other site 405532013094 D-loop; other site 405532013095 H-loop/switch region; other site 405532013096 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405532013097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532013098 dimer interface [polypeptide binding]; other site 405532013099 conserved gate region; other site 405532013100 putative PBP binding loops; other site 405532013101 ABC-ATPase subunit interface; other site 405532013102 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 405532013103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532013104 motif II; other site 405532013105 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 405532013106 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 405532013107 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 405532013108 nudix motif; other site 405532013109 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 405532013110 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405532013111 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405532013112 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405532013113 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405532013114 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405532013115 DNA binding residues [nucleotide binding] 405532013116 S-ribosylhomocysteinase; Provisional; Region: PRK02260 405532013117 Haemolytic domain; Region: Haemolytic; pfam01809 405532013118 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 405532013119 active site clefts [active] 405532013120 zinc binding site [ion binding]; other site 405532013121 dimer interface [polypeptide binding]; other site 405532013122 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405532013123 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 405532013124 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 405532013125 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405532013126 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405532013127 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405532013128 putative active site [active] 405532013129 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532013130 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532013131 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532013132 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532013133 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 405532013134 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 405532013135 Predicted membrane protein [Function unknown]; Region: COG3766 405532013136 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 405532013137 hypothetical protein; Provisional; Region: PRK12473 405532013138 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 405532013139 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 405532013140 G1 box; other site 405532013141 GTP/Mg2+ binding site [chemical binding]; other site 405532013142 Switch I region; other site 405532013143 G2 box; other site 405532013144 G3 box; other site 405532013145 Switch II region; other site 405532013146 G4 box; other site 405532013147 G5 box; other site 405532013148 Nucleoside recognition; Region: Gate; pfam07670 405532013149 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 405532013150 Nucleoside recognition; Region: Gate; pfam07670 405532013151 FeoA domain; Region: FeoA; pfam04023 405532013152 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 405532013153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532013154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532013155 dimerization interface [polypeptide binding]; other site 405532013156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532013157 dimer interface [polypeptide binding]; other site 405532013158 phosphorylation site [posttranslational modification] 405532013159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532013160 ATP binding site [chemical binding]; other site 405532013161 Mg2+ binding site [ion binding]; other site 405532013162 G-X-G motif; other site 405532013163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532013164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532013165 active site 405532013166 phosphorylation site [posttranslational modification] 405532013167 intermolecular recognition site; other site 405532013168 dimerization interface [polypeptide binding]; other site 405532013169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532013170 DNA binding site [nucleotide binding] 405532013171 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 405532013172 active site 405532013173 catalytic site [active] 405532013174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532013175 active site 405532013176 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 405532013177 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405532013178 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 405532013179 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 405532013180 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 405532013181 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 405532013182 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405532013183 FtsX-like permease family; Region: FtsX; pfam02687 405532013184 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532013185 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532013186 Walker A/P-loop; other site 405532013187 ATP binding site [chemical binding]; other site 405532013188 Q-loop/lid; other site 405532013189 ABC transporter signature motif; other site 405532013190 Walker B; other site 405532013191 D-loop; other site 405532013192 H-loop/switch region; other site 405532013193 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405532013194 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 405532013195 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405532013196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532013197 S-adenosylmethionine binding site [chemical binding]; other site 405532013198 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405532013199 FtsX-like permease family; Region: FtsX; pfam02687 405532013200 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532013201 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532013202 Walker A/P-loop; other site 405532013203 ATP binding site [chemical binding]; other site 405532013204 Q-loop/lid; other site 405532013205 ABC transporter signature motif; other site 405532013206 Walker B; other site 405532013207 D-loop; other site 405532013208 H-loop/switch region; other site 405532013209 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405532013210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405532013211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405532013212 Predicted integral membrane protein [Function unknown]; Region: COG5658 405532013213 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405532013214 SdpI/YhfL protein family; Region: SdpI; pfam13630 405532013215 Predicted integral membrane protein [Function unknown]; Region: COG5658 405532013216 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405532013217 SdpI/YhfL protein family; Region: SdpI; pfam13630 405532013218 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532013219 dimerization interface [polypeptide binding]; other site 405532013220 putative DNA binding site [nucleotide binding]; other site 405532013221 putative Zn2+ binding site [ion binding]; other site 405532013222 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532013223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532013224 active site 405532013225 phosphorylation site [posttranslational modification] 405532013226 intermolecular recognition site; other site 405532013227 dimerization interface [polypeptide binding]; other site 405532013228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532013229 DNA binding site [nucleotide binding] 405532013230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532013231 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 405532013232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532013233 ATP binding site [chemical binding]; other site 405532013234 Mg2+ binding site [ion binding]; other site 405532013235 G-X-G motif; other site 405532013236 FtsX-like permease family; Region: FtsX; pfam02687 405532013237 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532013238 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532013239 Walker A/P-loop; other site 405532013240 ATP binding site [chemical binding]; other site 405532013241 Q-loop/lid; other site 405532013242 ABC transporter signature motif; other site 405532013243 Walker B; other site 405532013244 D-loop; other site 405532013245 H-loop/switch region; other site 405532013246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532013247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532013248 GntP family permease; Region: GntP_permease; pfam02447 405532013249 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405532013250 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405532013251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405532013252 DNA-binding site [nucleotide binding]; DNA binding site 405532013253 UTRA domain; Region: UTRA; pfam07702 405532013254 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405532013255 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405532013256 substrate binding site [chemical binding]; other site 405532013257 ATP binding site [chemical binding]; other site 405532013258 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 405532013259 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405532013260 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532013261 catalytic residue [active] 405532013262 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 405532013263 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 405532013264 active site 405532013265 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405532013266 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405532013267 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405532013268 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 405532013269 dimerization interface [polypeptide binding]; other site 405532013270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532013271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532013272 dimer interface [polypeptide binding]; other site 405532013273 phosphorylation site [posttranslational modification] 405532013274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532013275 ATP binding site [chemical binding]; other site 405532013276 Mg2+ binding site [ion binding]; other site 405532013277 G-X-G motif; other site 405532013278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532013279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532013280 active site 405532013281 phosphorylation site [posttranslational modification] 405532013282 intermolecular recognition site; other site 405532013283 dimerization interface [polypeptide binding]; other site 405532013284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532013285 DNA binding site [nucleotide binding] 405532013286 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 405532013287 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 405532013288 active site 405532013289 octamer interface [polypeptide binding]; other site 405532013290 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 405532013291 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 405532013292 acyl-activating enzyme (AAE) consensus motif; other site 405532013293 putative AMP binding site [chemical binding]; other site 405532013294 putative active site [active] 405532013295 putative CoA binding site [chemical binding]; other site 405532013296 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405532013297 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 405532013298 substrate binding site [chemical binding]; other site 405532013299 oxyanion hole (OAH) forming residues; other site 405532013300 trimer interface [polypeptide binding]; other site 405532013301 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 405532013302 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405532013303 nucleophilic elbow; other site 405532013304 catalytic triad; other site 405532013305 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 405532013306 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 405532013307 dimer interface [polypeptide binding]; other site 405532013308 tetramer interface [polypeptide binding]; other site 405532013309 PYR/PP interface [polypeptide binding]; other site 405532013310 TPP binding site [chemical binding]; other site 405532013311 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 405532013312 TPP-binding site; other site 405532013313 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 405532013314 chorismate binding enzyme; Region: Chorismate_bind; cl10555 405532013315 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 405532013316 UbiA prenyltransferase family; Region: UbiA; pfam01040 405532013317 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 405532013318 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405532013319 DNA-binding site [nucleotide binding]; DNA binding site 405532013320 RNA-binding motif; other site 405532013321 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 405532013322 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 405532013323 active site flap/lid [active] 405532013324 nucleophilic elbow; other site 405532013325 catalytic triad [active] 405532013326 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 405532013327 homodimer interface [polypeptide binding]; other site 405532013328 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 405532013329 active site pocket [active] 405532013330 glycogen synthase; Provisional; Region: glgA; PRK00654 405532013331 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 405532013332 ADP-binding pocket [chemical binding]; other site 405532013333 homodimer interface [polypeptide binding]; other site 405532013334 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 405532013335 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 405532013336 ligand binding site; other site 405532013337 oligomer interface; other site 405532013338 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405532013339 dimer interface [polypeptide binding]; other site 405532013340 N-terminal domain interface [polypeptide binding]; other site 405532013341 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 405532013342 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 405532013343 ligand binding site; other site 405532013344 oligomer interface; other site 405532013345 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405532013346 dimer interface [polypeptide binding]; other site 405532013347 N-terminal domain interface [polypeptide binding]; other site 405532013348 sulfate 1 binding site; other site 405532013349 glycogen branching enzyme; Provisional; Region: PRK12313 405532013350 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 405532013351 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 405532013352 active site 405532013353 catalytic site [active] 405532013354 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 405532013355 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 405532013356 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405532013357 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405532013358 putative active site [active] 405532013359 catalytic triad [active] 405532013360 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 405532013361 PA/protease domain interface [polypeptide binding]; other site 405532013362 putative integrin binding motif; other site 405532013363 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405532013364 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 405532013365 dockerin binding interface; other site 405532013366 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405532013367 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405532013368 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405532013369 NAD binding site [chemical binding]; other site 405532013370 dimer interface [polypeptide binding]; other site 405532013371 substrate binding site [chemical binding]; other site 405532013372 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405532013373 MgtC family; Region: MgtC; pfam02308 405532013374 Ion channel; Region: Ion_trans_2; pfam07885 405532013375 TrkA-N domain; Region: TrkA_N; pfam02254 405532013376 YugN-like family; Region: YugN; pfam08868 405532013377 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 405532013378 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 405532013379 active site 405532013380 dimer interface [polypeptide binding]; other site 405532013381 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 405532013382 dimer interface [polypeptide binding]; other site 405532013383 active site 405532013384 Domain of unknown function (DUF378); Region: DUF378; pfam04070 405532013385 general stress protein 13; Validated; Region: PRK08059 405532013386 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405532013387 RNA binding site [nucleotide binding]; other site 405532013388 hypothetical protein; Validated; Region: PRK07682 405532013389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532013390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532013391 homodimer interface [polypeptide binding]; other site 405532013392 catalytic residue [active] 405532013393 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405532013394 AsnC family; Region: AsnC_trans_reg; pfam01037 405532013395 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 405532013396 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 405532013397 dimerization interface [polypeptide binding]; other site 405532013398 ligand binding site [chemical binding]; other site 405532013399 NADP binding site [chemical binding]; other site 405532013400 catalytic site [active] 405532013401 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405532013402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405532013403 nucleophilic elbow; other site 405532013404 catalytic triad; other site 405532013405 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 405532013406 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 405532013407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405532013408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532013409 homodimer interface [polypeptide binding]; other site 405532013410 catalytic residue [active] 405532013411 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 405532013412 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 405532013413 E-class dimer interface [polypeptide binding]; other site 405532013414 P-class dimer interface [polypeptide binding]; other site 405532013415 active site 405532013416 Cu2+ binding site [ion binding]; other site 405532013417 Zn2+ binding site [ion binding]; other site 405532013418 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 405532013419 Kinase associated protein B; Region: KapB; pfam08810 405532013420 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 405532013421 active site 405532013422 catalytic site [active] 405532013423 substrate binding site [chemical binding]; other site 405532013424 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405532013425 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 405532013426 transmembrane helices; other site 405532013427 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405532013428 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 405532013429 active site 405532013430 glycyl-tRNA synthetase; Provisional; Region: PRK04173 405532013431 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405532013432 motif 1; other site 405532013433 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 405532013434 active site 405532013435 motif 2; other site 405532013436 motif 3; other site 405532013437 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 405532013438 anticodon binding site; other site 405532013439 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 405532013440 CoenzymeA binding site [chemical binding]; other site 405532013441 subunit interaction site [polypeptide binding]; other site 405532013442 PHB binding site; other site 405532013443 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 405532013444 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 405532013445 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 405532013446 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405532013447 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405532013448 active site 405532013449 tetramer interface; other site 405532013450 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 405532013451 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 405532013452 active site 405532013453 substrate binding site [chemical binding]; other site 405532013454 metal binding site [ion binding]; metal-binding site 405532013455 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 405532013456 Uncharacterized conserved protein [Function unknown]; Region: COG1624 405532013457 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405532013458 Divergent PAP2 family; Region: DUF212; cl00855 405532013459 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 405532013460 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 405532013461 multifunctional aminopeptidase A; Provisional; Region: PRK00913 405532013462 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 405532013463 interface (dimer of trimers) [polypeptide binding]; other site 405532013464 Substrate-binding/catalytic site; other site 405532013465 Zn-binding sites [ion binding]; other site 405532013466 Divergent PAP2 family; Region: DUF212; cl00855 405532013467 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 405532013468 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 405532013469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405532013470 Putative membrane protein; Region: YuiB; pfam14068 405532013471 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405532013472 nudix motif; other site 405532013473 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405532013474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532013475 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 405532013476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532013477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532013478 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405532013479 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405532013480 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405532013481 Domain of unknown function DUF11; Region: DUF11; pfam01345 405532013482 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532013483 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532013484 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532013485 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532013486 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532013487 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405532013488 Domain of unknown function DUF11; Region: DUF11; cl17728 405532013489 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405532013490 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405532013491 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405532013492 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405532013493 Domain of unknown function DUF11; Region: DUF11; cl17728 405532013494 Domain of unknown function DUF11; Region: DUF11; pfam01345 405532013495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405532013496 H+ Antiporter protein; Region: 2A0121; TIGR00900 405532013497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532013498 putative substrate translocation pore; other site 405532013499 Helix-turn-helix domain; Region: HTH_36; pfam13730 405532013500 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405532013501 Uncharacterized conserved protein [Function unknown]; Region: COG1683 405532013502 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405532013503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405532013504 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 405532013505 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 405532013506 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405532013507 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405532013508 hypothetical protein; Provisional; Region: PRK13669 405532013509 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405532013510 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532013511 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405532013512 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532013513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532013514 Walker A/P-loop; other site 405532013515 ATP binding site [chemical binding]; other site 405532013516 Q-loop/lid; other site 405532013517 ABC transporter signature motif; other site 405532013518 Walker B; other site 405532013519 D-loop; other site 405532013520 H-loop/switch region; other site 405532013521 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 405532013522 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 405532013523 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 405532013524 PhnA protein; Region: PhnA; pfam03831 405532013525 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 405532013526 PQQ-like domain; Region: PQQ_2; pfam13360 405532013527 PQQ-like domain; Region: PQQ_2; pfam13360 405532013528 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 405532013529 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405532013530 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 405532013531 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405532013532 active site 405532013533 NTP binding site [chemical binding]; other site 405532013534 metal binding triad [ion binding]; metal-binding site 405532013535 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 405532013536 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 405532013537 NifU-like domain; Region: NifU; pfam01106 405532013538 spore coat protein YutH; Region: spore_yutH; TIGR02905 405532013539 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 405532013540 tetramer interfaces [polypeptide binding]; other site 405532013541 binuclear metal-binding site [ion binding]; other site 405532013542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532013543 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532013544 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 405532013545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532013546 active site 405532013547 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 405532013548 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 405532013549 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 405532013550 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 405532013551 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405532013552 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 405532013553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532013554 active site 405532013555 motif I; other site 405532013556 motif II; other site 405532013557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532013558 Predicted transcriptional regulator [Transcription]; Region: COG2345 405532013559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532013560 putative Zn2+ binding site [ion binding]; other site 405532013561 putative DNA binding site [nucleotide binding]; other site 405532013562 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 405532013563 Uncharacterized conserved protein [Function unknown]; Region: COG2445 405532013564 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 405532013565 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 405532013566 putative active site [active] 405532013567 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 405532013568 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 405532013569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532013570 RNA binding surface [nucleotide binding]; other site 405532013571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405532013572 Coenzyme A binding pocket [chemical binding]; other site 405532013573 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 405532013574 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405532013575 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405532013576 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405532013577 DNA binding residues [nucleotide binding] 405532013578 dimer interface [polypeptide binding]; other site 405532013579 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405532013580 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 405532013581 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405532013582 catalytic core [active] 405532013583 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 405532013584 putative deacylase active site [active] 405532013585 lipoyl synthase; Provisional; Region: PRK05481 405532013586 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532013587 FeS/SAM binding site; other site 405532013588 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405532013589 Peptidase family M23; Region: Peptidase_M23; pfam01551 405532013590 sporulation protein YunB; Region: spo_yunB; TIGR02832 405532013591 Uncharacterized conserved protein [Function unknown]; Region: COG3377 405532013592 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 405532013593 FeS assembly protein SufB; Region: sufB; TIGR01980 405532013594 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 405532013595 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 405532013596 trimerization site [polypeptide binding]; other site 405532013597 active site 405532013598 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 405532013599 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 405532013600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405532013601 catalytic residue [active] 405532013602 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 405532013603 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 405532013604 FeS assembly protein SufD; Region: sufD; TIGR01981 405532013605 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 405532013606 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 405532013607 Walker A/P-loop; other site 405532013608 ATP binding site [chemical binding]; other site 405532013609 Q-loop/lid; other site 405532013610 ABC transporter signature motif; other site 405532013611 Walker B; other site 405532013612 D-loop; other site 405532013613 H-loop/switch region; other site 405532013614 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405532013615 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405532013616 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405532013617 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405532013618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405532013619 ABC-ATPase subunit interface; other site 405532013620 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 405532013621 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405532013622 Walker A/P-loop; other site 405532013623 ATP binding site [chemical binding]; other site 405532013624 Q-loop/lid; other site 405532013625 ABC transporter signature motif; other site 405532013626 Walker B; other site 405532013627 D-loop; other site 405532013628 H-loop/switch region; other site 405532013629 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 405532013630 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405532013631 catalytic residues [active] 405532013632 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 405532013633 putative active site [active] 405532013634 putative metal binding site [ion binding]; other site 405532013635 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 405532013636 lipoyl attachment site [posttranslational modification]; other site 405532013637 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 405532013638 ArsC family; Region: ArsC; pfam03960 405532013639 putative ArsC-like catalytic residues; other site 405532013640 putative TRX-like catalytic residues [active] 405532013641 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 405532013642 active site 405532013643 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 405532013644 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 405532013645 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405532013646 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405532013647 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405532013648 NAD binding site [chemical binding]; other site 405532013649 dimer interface [polypeptide binding]; other site 405532013650 substrate binding site [chemical binding]; other site 405532013651 Coat F domain; Region: Coat_F; pfam07875 405532013652 CAAX protease self-immunity; Region: Abi; pfam02517 405532013653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532013654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532013655 WHG domain; Region: WHG; pfam13305 405532013656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405532013657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405532013658 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405532013659 active site 405532013660 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 405532013661 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405532013662 dimer interface [polypeptide binding]; other site 405532013663 active site 405532013664 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 405532013665 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405532013666 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405532013667 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405532013668 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405532013669 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 405532013670 substrate binding site [chemical binding]; other site 405532013671 oxyanion hole (OAH) forming residues; other site 405532013672 YuzL-like protein; Region: YuzL; pfam14115 405532013673 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532013674 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405532013675 Proline dehydrogenase; Region: Pro_dh; cl03282 405532013676 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 405532013677 Domain of unknown function DUF77; Region: DUF77; pfam01910 405532013678 Cache domain; Region: Cache_1; pfam02743 405532013679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532013680 dimerization interface [polypeptide binding]; other site 405532013681 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532013682 dimer interface [polypeptide binding]; other site 405532013683 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532013684 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532013685 dimer interface [polypeptide binding]; other site 405532013686 putative CheW interface [polypeptide binding]; other site 405532013687 Predicted transcriptional regulators [Transcription]; Region: COG1378 405532013688 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405532013689 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405532013690 C-terminal domain interface [polypeptide binding]; other site 405532013691 sugar binding site [chemical binding]; other site 405532013692 tellurium resistance terB-like protein; Region: terB_like; cd07177 405532013693 metal binding site [ion binding]; metal-binding site 405532013694 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405532013695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532013696 putative substrate translocation pore; other site 405532013697 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 405532013698 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 405532013699 Spore germination protein; Region: Spore_permease; cl17796 405532013700 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 405532013701 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405532013702 OxaA-like protein precursor; Validated; Region: PRK01622 405532013703 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405532013704 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405532013705 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405532013706 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405532013707 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532013708 hypothetical protein; Provisional; Region: PRK06758 405532013709 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 405532013710 active site 405532013711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532013712 non-specific DNA binding site [nucleotide binding]; other site 405532013713 salt bridge; other site 405532013714 sequence-specific DNA binding site [nucleotide binding]; other site 405532013715 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405532013716 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405532013717 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 405532013718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405532013719 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405532013720 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532013721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532013722 active site 405532013723 phosphorylation site [posttranslational modification] 405532013724 intermolecular recognition site; other site 405532013725 dimerization interface [polypeptide binding]; other site 405532013726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532013727 DNA binding site [nucleotide binding] 405532013728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405532013729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532013730 dimer interface [polypeptide binding]; other site 405532013731 phosphorylation site [posttranslational modification] 405532013732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532013733 ATP binding site [chemical binding]; other site 405532013734 Mg2+ binding site [ion binding]; other site 405532013735 G-X-G motif; other site 405532013736 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405532013737 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 405532013738 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405532013739 active site 405532013740 HIGH motif; other site 405532013741 KMSKS motif; other site 405532013742 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405532013743 tRNA binding surface [nucleotide binding]; other site 405532013744 anticodon binding site; other site 405532013745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532013746 S-adenosylmethionine binding site [chemical binding]; other site 405532013747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532013748 dimerization interface [polypeptide binding]; other site 405532013749 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532013750 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532013751 dimer interface [polypeptide binding]; other site 405532013752 putative CheW interface [polypeptide binding]; other site 405532013753 CHASE3 domain; Region: CHASE3; cl05000 405532013754 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405532013755 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532013756 dimerization interface [polypeptide binding]; other site 405532013757 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532013758 dimer interface [polypeptide binding]; other site 405532013759 putative CheW interface [polypeptide binding]; other site 405532013760 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 405532013761 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405532013762 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405532013763 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405532013764 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405532013765 active site 405532013766 Zn binding site [ion binding]; other site 405532013767 Pirin-related protein [General function prediction only]; Region: COG1741 405532013768 Pirin; Region: Pirin; pfam02678 405532013769 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 405532013770 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405532013771 MarR family; Region: MarR_2; pfam12802 405532013772 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 405532013773 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405532013774 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405532013775 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405532013776 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405532013777 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 405532013778 TrkA-C domain; Region: TrkA_C; pfam02080 405532013779 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405532013780 amino acid carrier protein; Region: agcS; TIGR00835 405532013781 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405532013782 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405532013783 dimerization interface [polypeptide binding]; other site 405532013784 DPS ferroxidase diiron center [ion binding]; other site 405532013785 ion pore; other site 405532013786 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 405532013787 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 405532013788 metal binding site [ion binding]; metal-binding site 405532013789 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 405532013790 Ferritin-like domain; Region: Ferritin; pfam00210 405532013791 ferroxidase diiron center [ion binding]; other site 405532013792 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405532013793 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405532013794 Nucleoside recognition; Region: Gate; pfam07670 405532013795 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405532013796 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405532013797 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405532013798 Nucleoside recognition; Region: Gate; pfam07670 405532013799 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405532013800 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405532013801 amino acid carrier protein; Region: agcS; TIGR00835 405532013802 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405532013803 amino acid carrier protein; Region: agcS; TIGR00835 405532013804 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405532013805 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405532013806 NAD binding site [chemical binding]; other site 405532013807 substrate binding site [chemical binding]; other site 405532013808 putative active site [active] 405532013809 Peptidase M60-like family; Region: M60-like; pfam13402 405532013810 TQXA domain; Region: TQXA_dom; TIGR03934 405532013811 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405532013812 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405532013813 active site 405532013814 catalytic tetrad [active] 405532013815 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405532013816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532013817 putative substrate translocation pore; other site 405532013818 Predicted transcriptional regulators [Transcription]; Region: COG1733 405532013819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532013820 dimerization interface [polypeptide binding]; other site 405532013821 putative DNA binding site [nucleotide binding]; other site 405532013822 putative Zn2+ binding site [ion binding]; other site 405532013823 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405532013824 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405532013825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532013826 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 405532013827 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 405532013828 active site 405532013829 HIGH motif; other site 405532013830 dimer interface [polypeptide binding]; other site 405532013831 KMSKS motif; other site 405532013832 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405532013833 RNA binding surface [nucleotide binding]; other site 405532013834 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 405532013835 FAD binding domain; Region: FAD_binding_4; pfam01565 405532013836 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405532013837 SET domain; Region: SET; pfam00856 405532013838 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 405532013839 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532013840 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532013841 dimer interface [polypeptide binding]; other site 405532013842 putative CheW interface [polypeptide binding]; other site 405532013843 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 405532013844 putative phosphate binding site [ion binding]; other site 405532013845 camphor resistance protein CrcB; Provisional; Region: PRK14219 405532013846 camphor resistance protein CrcB; Provisional; Region: PRK14205 405532013847 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 405532013848 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 405532013849 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405532013850 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405532013851 Coenzyme A binding pocket [chemical binding]; other site 405532013852 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 405532013853 Nuclease-related domain; Region: NERD; pfam08378 405532013854 MarR family; Region: MarR_2; pfam12802 405532013855 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 405532013856 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 405532013857 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405532013858 Walker A/P-loop; other site 405532013859 ATP binding site [chemical binding]; other site 405532013860 Q-loop/lid; other site 405532013861 ABC transporter signature motif; other site 405532013862 Walker B; other site 405532013863 D-loop; other site 405532013864 H-loop/switch region; other site 405532013865 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532013866 ABC-ATPase subunit interface; other site 405532013867 dimer interface [polypeptide binding]; other site 405532013868 putative PBP binding regions; other site 405532013869 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405532013870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532013871 ABC-ATPase subunit interface; other site 405532013872 dimer interface [polypeptide binding]; other site 405532013873 putative PBP binding regions; other site 405532013874 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 405532013875 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 405532013876 putative ligand binding residues [chemical binding]; other site 405532013877 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532013878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532013879 active site 405532013880 phosphorylation site [posttranslational modification] 405532013881 intermolecular recognition site; other site 405532013882 dimerization interface [polypeptide binding]; other site 405532013883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532013884 DNA binding site [nucleotide binding] 405532013885 DinB family; Region: DinB; cl17821 405532013886 Predicted transcriptional regulator [Transcription]; Region: COG2378 405532013887 HTH domain; Region: HTH_11; pfam08279 405532013888 WYL domain; Region: WYL; pfam13280 405532013889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 405532013890 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 405532013891 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 405532013892 SmpB-tmRNA interface; other site 405532013893 ribonuclease R; Region: RNase_R; TIGR02063 405532013894 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 405532013895 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405532013896 RNB domain; Region: RNB; pfam00773 405532013897 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 405532013898 RNA binding site [nucleotide binding]; other site 405532013899 Esterase/lipase [General function prediction only]; Region: COG1647 405532013900 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 405532013901 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405532013902 holin-like protein; Validated; Region: PRK01658 405532013903 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405532013904 active site 405532013905 enolase; Provisional; Region: eno; PRK00077 405532013906 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 405532013907 dimer interface [polypeptide binding]; other site 405532013908 metal binding site [ion binding]; metal-binding site 405532013909 substrate binding pocket [chemical binding]; other site 405532013910 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 405532013911 phosphoglyceromutase; Provisional; Region: PRK05434 405532013912 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 405532013913 triosephosphate isomerase; Provisional; Region: PRK14565 405532013914 substrate binding site [chemical binding]; other site 405532013915 dimer interface [polypeptide binding]; other site 405532013916 catalytic triad [active] 405532013917 Phosphoglycerate kinase; Region: PGK; pfam00162 405532013918 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 405532013919 substrate binding site [chemical binding]; other site 405532013920 hinge regions; other site 405532013921 ADP binding site [chemical binding]; other site 405532013922 catalytic site [active] 405532013923 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 405532013924 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 405532013925 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405532013926 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405532013927 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405532013928 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 405532013929 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 405532013930 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 405532013931 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 405532013932 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 405532013933 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 405532013934 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405532013935 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 405532013936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532013937 Walker A/P-loop; other site 405532013938 ATP binding site [chemical binding]; other site 405532013939 Q-loop/lid; other site 405532013940 ABC transporter signature motif; other site 405532013941 Walker B; other site 405532013942 D-loop; other site 405532013943 H-loop/switch region; other site 405532013944 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 405532013945 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 405532013946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405532013947 Histidine kinase; Region: HisKA_3; pfam07730 405532013948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532013949 ATP binding site [chemical binding]; other site 405532013950 Mg2+ binding site [ion binding]; other site 405532013951 G-X-G motif; other site 405532013952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405532013953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532013954 active site 405532013955 phosphorylation site [posttranslational modification] 405532013956 intermolecular recognition site; other site 405532013957 dimerization interface [polypeptide binding]; other site 405532013958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405532013959 DNA binding residues [nucleotide binding] 405532013960 dimerization interface [polypeptide binding]; other site 405532013961 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405532013962 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405532013963 stage V sporulation protein AD; Provisional; Region: PRK12404 405532013964 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 405532013965 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405532013966 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405532013967 Predicted membrane protein [Function unknown]; Region: COG2323 405532013968 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405532013969 Clp protease; Region: CLP_protease; pfam00574 405532013970 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405532013971 oligomer interface [polypeptide binding]; other site 405532013972 active site residues [active] 405532013973 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405532013974 dimerization domain swap beta strand [polypeptide binding]; other site 405532013975 regulatory protein interface [polypeptide binding]; other site 405532013976 active site 405532013977 regulatory phosphorylation site [posttranslational modification]; other site 405532013978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 405532013979 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 405532013980 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 405532013981 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 405532013982 phosphate binding site [ion binding]; other site 405532013983 putative substrate binding pocket [chemical binding]; other site 405532013984 dimer interface [polypeptide binding]; other site 405532013985 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 405532013986 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405532013987 putative active site [active] 405532013988 nucleotide binding site [chemical binding]; other site 405532013989 nudix motif; other site 405532013990 putative metal binding site [ion binding]; other site 405532013991 Domain of unknown function (DUF368); Region: DUF368; pfam04018 405532013992 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 405532013993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405532013994 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405532013995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532013996 binding surface 405532013997 TPR motif; other site 405532013998 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405532013999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405532014000 binding surface 405532014001 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405532014002 TPR motif; other site 405532014003 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405532014004 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 405532014005 trimer interface [polypeptide binding]; other site 405532014006 active site 405532014007 substrate binding site [chemical binding]; other site 405532014008 CoA binding site [chemical binding]; other site 405532014009 pyrophosphatase PpaX; Provisional; Region: PRK13288 405532014010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532014011 active site 405532014012 motif I; other site 405532014013 motif II; other site 405532014014 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 405532014015 HPr kinase/phosphorylase; Provisional; Region: PRK05428 405532014016 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 405532014017 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 405532014018 Hpr binding site; other site 405532014019 active site 405532014020 homohexamer subunit interaction site [polypeptide binding]; other site 405532014021 Predicted membrane protein [Function unknown]; Region: COG1950 405532014022 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 405532014023 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 405532014024 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405532014025 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405532014026 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 405532014027 excinuclease ABC subunit B; Provisional; Region: PRK05298 405532014028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532014029 ATP binding site [chemical binding]; other site 405532014030 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532014031 nucleotide binding region [chemical binding]; other site 405532014032 ATP-binding site [chemical binding]; other site 405532014033 Ultra-violet resistance protein B; Region: UvrB; pfam12344 405532014034 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 405532014035 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405532014036 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405532014037 DNA binding residues [nucleotide binding] 405532014038 dimer interface [polypeptide binding]; other site 405532014039 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405532014040 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405532014041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532014042 non-specific DNA binding site [nucleotide binding]; other site 405532014043 salt bridge; other site 405532014044 sequence-specific DNA binding site [nucleotide binding]; other site 405532014045 Predicted membrane protein [Function unknown]; Region: COG2855 405532014046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532014047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532014048 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 405532014049 putative dimerization interface [polypeptide binding]; other site 405532014050 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 405532014051 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405532014052 DNA binding residues [nucleotide binding] 405532014053 putative dimer interface [polypeptide binding]; other site 405532014054 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 405532014055 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405532014056 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405532014057 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532014058 ABC transporter; Region: ABC_tran_2; pfam12848 405532014059 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532014060 hypothetical protein; Provisional; Region: PRK12855 405532014061 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405532014062 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405532014063 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405532014064 Walker A/P-loop; other site 405532014065 ATP binding site [chemical binding]; other site 405532014066 Q-loop/lid; other site 405532014067 ABC transporter signature motif; other site 405532014068 Walker B; other site 405532014069 D-loop; other site 405532014070 H-loop/switch region; other site 405532014071 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405532014072 protein binding site [polypeptide binding]; other site 405532014073 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 405532014074 C-terminal peptidase (prc); Region: prc; TIGR00225 405532014075 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 405532014076 protein binding site [polypeptide binding]; other site 405532014077 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 405532014078 Catalytic dyad [active] 405532014079 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405532014080 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 405532014081 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 405532014082 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 405532014083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532014084 Walker A/P-loop; other site 405532014085 ATP binding site [chemical binding]; other site 405532014086 Q-loop/lid; other site 405532014087 ABC transporter signature motif; other site 405532014088 Walker B; other site 405532014089 D-loop; other site 405532014090 H-loop/switch region; other site 405532014091 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405532014092 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405532014093 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 405532014094 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 405532014095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 405532014096 nucleotide binding region [chemical binding]; other site 405532014097 ATP-binding site [chemical binding]; other site 405532014098 SEC-C motif; Region: SEC-C; pfam02810 405532014099 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 405532014100 30S subunit binding site; other site 405532014101 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405532014102 DNA-binding site [nucleotide binding]; DNA binding site 405532014103 RNA-binding motif; other site 405532014104 comF family protein; Region: comF; TIGR00201 405532014105 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532014106 active site 405532014107 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 405532014108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532014109 ATP binding site [chemical binding]; other site 405532014110 putative Mg++ binding site [ion binding]; other site 405532014111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532014112 nucleotide binding region [chemical binding]; other site 405532014113 ATP-binding site [chemical binding]; other site 405532014114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405532014115 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 405532014116 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405532014117 NlpC/P60 family; Region: NLPC_P60; pfam00877 405532014118 Predicted transcriptional regulators [Transcription]; Region: COG1733 405532014119 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405532014120 dimerization interface [polypeptide binding]; other site 405532014121 putative DNA binding site [nucleotide binding]; other site 405532014122 putative Zn2+ binding site [ion binding]; other site 405532014123 EDD domain protein, DegV family; Region: DegV; TIGR00762 405532014124 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405532014125 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 405532014126 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 405532014127 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 405532014128 Transcriptional regulator [Transcription]; Region: LytR; COG1316 405532014129 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 405532014130 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 405532014131 active site 405532014132 homodimer interface [polypeptide binding]; other site 405532014133 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 405532014134 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405532014135 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405532014136 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 405532014137 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 405532014138 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 405532014139 Mg++ binding site [ion binding]; other site 405532014140 putative catalytic motif [active] 405532014141 substrate binding site [chemical binding]; other site 405532014142 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405532014143 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405532014144 NodB motif; other site 405532014145 active site 405532014146 catalytic site [active] 405532014147 Zn binding site [ion binding]; other site 405532014148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405532014149 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405532014150 Walker A motif; other site 405532014151 ATP binding site [chemical binding]; other site 405532014152 Walker B motif; other site 405532014153 arginine finger; other site 405532014154 Transcriptional antiterminator [Transcription]; Region: COG3933 405532014155 PRD domain; Region: PRD; pfam00874 405532014156 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405532014157 active pocket/dimerization site; other site 405532014158 active site 405532014159 phosphorylation site [posttranslational modification] 405532014160 PRD domain; Region: PRD; pfam00874 405532014161 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 405532014162 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 405532014163 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 405532014164 Chromate transporter; Region: Chromate_transp; pfam02417 405532014165 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 405532014166 putative active site [active] 405532014167 YdjC motif; other site 405532014168 Mg binding site [ion binding]; other site 405532014169 putative homodimer interface [polypeptide binding]; other site 405532014170 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 405532014171 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 405532014172 NAD binding site [chemical binding]; other site 405532014173 sugar binding site [chemical binding]; other site 405532014174 divalent metal binding site [ion binding]; other site 405532014175 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405532014176 dimer interface [polypeptide binding]; other site 405532014177 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405532014178 active site 405532014179 methionine cluster; other site 405532014180 phosphorylation site [posttranslational modification] 405532014181 metal binding site [ion binding]; metal-binding site 405532014182 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405532014183 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405532014184 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405532014185 active site 405532014186 P-loop; other site 405532014187 phosphorylation site [posttranslational modification] 405532014188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532014189 S-adenosylmethionine binding site [chemical binding]; other site 405532014190 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 405532014191 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 405532014192 methionine cluster; other site 405532014193 active site 405532014194 phosphorylation site [posttranslational modification] 405532014195 metal binding site [ion binding]; metal-binding site 405532014196 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405532014197 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 405532014198 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405532014199 active site 405532014200 P-loop; other site 405532014201 phosphorylation site [posttranslational modification] 405532014202 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 405532014203 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405532014204 Acyltransferase family; Region: Acyl_transf_3; pfam01757 405532014205 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 405532014206 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405532014207 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 405532014208 Predicted membrane protein [Function unknown]; Region: COG1511 405532014209 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405532014210 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405532014211 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405532014212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405532014213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405532014214 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 405532014215 putative dimerization interface [polypeptide binding]; other site 405532014216 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405532014217 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 405532014218 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 405532014219 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405532014220 transmembrane helices; other site 405532014221 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 405532014222 ThiC-associated domain; Region: ThiC-associated; pfam13667 405532014223 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 405532014224 L-lactate permease; Region: Lactate_perm; cl00701 405532014225 glycolate transporter; Provisional; Region: PRK09695 405532014226 Tic20-like protein; Region: Tic20; pfam09685 405532014227 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 405532014228 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 405532014229 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405532014230 Sulfatase; Region: Sulfatase; pfam00884 405532014231 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405532014232 homodimer interface [polypeptide binding]; other site 405532014233 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405532014234 substrate-cofactor binding pocket; other site 405532014235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532014236 catalytic residue [active] 405532014237 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532014238 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532014239 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532014240 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532014241 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532014242 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405532014243 NlpC/P60 family; Region: NLPC_P60; pfam00877 405532014244 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405532014245 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405532014246 Nucleoside recognition; Region: Gate; pfam07670 405532014247 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405532014248 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 405532014249 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405532014250 DXD motif; other site 405532014251 BCCT family transporter; Region: BCCT; pfam02028 405532014252 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532014253 Bacterial SH3 domain; Region: SH3_3; pfam08239 405532014254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405532014255 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 405532014256 Predicted membrane protein [Function unknown]; Region: COG4640 405532014257 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 405532014258 Double zinc ribbon; Region: DZR; pfam12773 405532014259 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 405532014260 Double zinc ribbon; Region: DZR; pfam12773 405532014261 SNF2 Helicase protein; Region: DUF3670; pfam12419 405532014262 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 405532014263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405532014264 ATP binding site [chemical binding]; other site 405532014265 putative Mg++ binding site [ion binding]; other site 405532014266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532014267 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 405532014268 nucleotide binding region [chemical binding]; other site 405532014269 ATP-binding site [chemical binding]; other site 405532014270 Predicted integral membrane protein [Function unknown]; Region: COG5652 405532014271 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 405532014272 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 405532014273 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 405532014274 ComK protein; Region: ComK; cl11560 405532014275 RNA polymerase factor sigma-70; Validated; Region: PRK06759 405532014276 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532014277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405532014278 DNA binding residues [nucleotide binding] 405532014279 Yip1 domain; Region: Yip1; cl17815 405532014280 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405532014281 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405532014282 FtsX-like permease family; Region: FtsX; pfam02687 405532014283 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405532014284 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405532014285 Walker A/P-loop; other site 405532014286 ATP binding site [chemical binding]; other site 405532014287 Q-loop/lid; other site 405532014288 ABC transporter signature motif; other site 405532014289 Walker B; other site 405532014290 D-loop; other site 405532014291 H-loop/switch region; other site 405532014292 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405532014293 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405532014294 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 405532014295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532014296 putative substrate translocation pore; other site 405532014297 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405532014298 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 405532014299 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 405532014300 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405532014301 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532014302 dimerization interface [polypeptide binding]; other site 405532014303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532014304 dimer interface [polypeptide binding]; other site 405532014305 phosphorylation site [posttranslational modification] 405532014306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532014307 ATP binding site [chemical binding]; other site 405532014308 Mg2+ binding site [ion binding]; other site 405532014309 G-X-G motif; other site 405532014310 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532014311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532014312 active site 405532014313 phosphorylation site [posttranslational modification] 405532014314 intermolecular recognition site; other site 405532014315 dimerization interface [polypeptide binding]; other site 405532014316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532014317 DNA binding site [nucleotide binding] 405532014318 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 405532014319 active site 405532014320 catalytic triad [active] 405532014321 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 405532014322 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405532014323 UDP-glucose 4-epimerase; Region: PLN02240 405532014324 NAD binding site [chemical binding]; other site 405532014325 homodimer interface [polypeptide binding]; other site 405532014326 active site 405532014327 substrate binding site [chemical binding]; other site 405532014328 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405532014329 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405532014330 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 405532014331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405532014332 putative ADP-binding pocket [chemical binding]; other site 405532014333 cell surface protein SprA; Region: surface_SprA; TIGR04189 405532014334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405532014335 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 405532014336 putative ADP-binding pocket [chemical binding]; other site 405532014337 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 405532014338 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 405532014339 Bacterial sugar transferase; Region: Bac_transf; pfam02397 405532014340 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 405532014341 DNA photolyase; Region: DNA_photolyase; pfam00875 405532014342 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405532014343 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405532014344 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 405532014345 Chain length determinant protein; Region: Wzz; cl15801 405532014346 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405532014347 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405532014348 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405532014349 rod shape-determining protein Mbl; Provisional; Region: PRK13928 405532014350 MreB and similar proteins; Region: MreB_like; cd10225 405532014351 nucleotide binding site [chemical binding]; other site 405532014352 Mg binding site [ion binding]; other site 405532014353 putative protofilament interaction site [polypeptide binding]; other site 405532014354 RodZ interaction site [polypeptide binding]; other site 405532014355 Stage III sporulation protein D; Region: SpoIIID; cl17560 405532014356 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405532014357 Peptidase family M23; Region: Peptidase_M23; pfam01551 405532014358 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405532014359 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 405532014360 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532014361 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532014362 Walker A/P-loop; other site 405532014363 ATP binding site [chemical binding]; other site 405532014364 Q-loop/lid; other site 405532014365 ABC transporter signature motif; other site 405532014366 Walker B; other site 405532014367 D-loop; other site 405532014368 H-loop/switch region; other site 405532014369 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405532014370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405532014371 Q-loop/lid; other site 405532014372 ABC transporter signature motif; other site 405532014373 Walker B; other site 405532014374 D-loop; other site 405532014375 H-loop/switch region; other site 405532014376 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405532014377 LytTr DNA-binding domain; Region: LytTR; pfam04397 405532014378 Stage II sporulation protein; Region: SpoIID; pfam08486 405532014379 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 405532014380 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405532014381 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405532014382 hinge; other site 405532014383 active site 405532014384 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 405532014385 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 405532014386 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 405532014387 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405532014388 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 405532014389 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405532014390 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 405532014391 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 405532014392 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405532014393 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 405532014394 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 405532014395 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 405532014396 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 405532014397 4Fe-4S binding domain; Region: Fer4; cl02805 405532014398 4Fe-4S binding domain; Region: Fer4; pfam00037 405532014399 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 405532014400 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 405532014401 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 405532014402 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 405532014403 NADH dehydrogenase subunit C; Validated; Region: PRK07735 405532014404 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 405532014405 NADH dehydrogenase subunit B; Validated; Region: PRK06411 405532014406 NADH dehydrogenase subunit A; Validated; Region: PRK07756 405532014407 PAS domain S-box; Region: sensory_box; TIGR00229 405532014408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532014409 putative active site [active] 405532014410 heme pocket [chemical binding]; other site 405532014411 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405532014412 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405532014413 metal binding site [ion binding]; metal-binding site 405532014414 active site 405532014415 I-site; other site 405532014416 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405532014417 Protein of unknown function (DUF975); Region: DUF975; cl10504 405532014418 Protein of unknown function (DUF975); Region: DUF975; cl10504 405532014419 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 405532014420 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 405532014421 gamma subunit interface [polypeptide binding]; other site 405532014422 epsilon subunit interface [polypeptide binding]; other site 405532014423 LBP interface [polypeptide binding]; other site 405532014424 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 405532014425 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405532014426 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 405532014427 alpha subunit interaction interface [polypeptide binding]; other site 405532014428 Walker A motif; other site 405532014429 ATP binding site [chemical binding]; other site 405532014430 Walker B motif; other site 405532014431 inhibitor binding site; inhibition site 405532014432 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405532014433 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 405532014434 core domain interface [polypeptide binding]; other site 405532014435 delta subunit interface [polypeptide binding]; other site 405532014436 epsilon subunit interface [polypeptide binding]; other site 405532014437 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 405532014438 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405532014439 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 405532014440 beta subunit interaction interface [polypeptide binding]; other site 405532014441 Walker A motif; other site 405532014442 ATP binding site [chemical binding]; other site 405532014443 Walker B motif; other site 405532014444 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405532014445 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 405532014446 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 405532014447 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 405532014448 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 405532014449 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 405532014450 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 405532014451 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 405532014452 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405532014453 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 405532014454 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 405532014455 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405532014456 active site 405532014457 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 405532014458 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 405532014459 dimer interface [polypeptide binding]; other site 405532014460 active site 405532014461 glycine-pyridoxal phosphate binding site [chemical binding]; other site 405532014462 folate binding site [chemical binding]; other site 405532014463 hypothetical protein; Provisional; Region: PRK13690 405532014464 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 405532014465 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405532014466 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405532014467 active site 405532014468 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405532014469 HPr interaction site; other site 405532014470 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405532014471 active site 405532014472 phosphorylation site [posttranslational modification] 405532014473 Predicted membrane protein [Function unknown]; Region: COG2259 405532014474 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 405532014475 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 405532014476 Predicted membrane protein [Function unknown]; Region: COG1971 405532014477 Domain of unknown function DUF; Region: DUF204; pfam02659 405532014478 Domain of unknown function DUF; Region: DUF204; pfam02659 405532014479 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 405532014480 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 405532014481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405532014482 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 405532014483 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 405532014484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532014485 S-adenosylmethionine binding site [chemical binding]; other site 405532014486 peptide chain release factor 1; Validated; Region: prfA; PRK00591 405532014487 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405532014488 RF-1 domain; Region: RF-1; pfam00472 405532014489 thymidine kinase; Provisional; Region: PRK04296 405532014490 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 405532014491 transcription termination factor Rho; Provisional; Region: rho; PRK09376 405532014492 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 405532014493 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 405532014494 RNA binding site [nucleotide binding]; other site 405532014495 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 405532014496 multimer interface [polypeptide binding]; other site 405532014497 Walker A motif; other site 405532014498 ATP binding site [chemical binding]; other site 405532014499 Walker B motif; other site 405532014500 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 405532014501 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 405532014502 putative active site [active] 405532014503 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405532014504 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405532014505 hinge; other site 405532014506 active site 405532014507 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 405532014508 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405532014509 intersubunit interface [polypeptide binding]; other site 405532014510 active site 405532014511 zinc binding site [ion binding]; other site 405532014512 Na+ binding site [ion binding]; other site 405532014513 Response regulator receiver domain; Region: Response_reg; pfam00072 405532014514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532014515 active site 405532014516 phosphorylation site [posttranslational modification] 405532014517 intermolecular recognition site; other site 405532014518 dimerization interface [polypeptide binding]; other site 405532014519 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 405532014520 CTP synthetase; Validated; Region: pyrG; PRK05380 405532014521 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 405532014522 Catalytic site [active] 405532014523 active site 405532014524 UTP binding site [chemical binding]; other site 405532014525 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 405532014526 active site 405532014527 putative oxyanion hole; other site 405532014528 catalytic triad [active] 405532014529 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 405532014530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532014531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532014532 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405532014533 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405532014534 FAD binding site [chemical binding]; other site 405532014535 homotetramer interface [polypeptide binding]; other site 405532014536 substrate binding pocket [chemical binding]; other site 405532014537 catalytic base [active] 405532014538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405532014539 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405532014540 FAD binding site [chemical binding]; other site 405532014541 homotetramer interface [polypeptide binding]; other site 405532014542 substrate binding pocket [chemical binding]; other site 405532014543 catalytic base [active] 405532014544 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 405532014545 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405532014546 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405532014547 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 405532014548 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405532014549 dimer interface [polypeptide binding]; other site 405532014550 active site 405532014551 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405532014552 4Fe-4S binding domain; Region: Fer4; cl02805 405532014553 Cysteine-rich domain; Region: CCG; pfam02754 405532014554 Cysteine-rich domain; Region: CCG; pfam02754 405532014555 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405532014556 PLD-like domain; Region: PLDc_2; pfam13091 405532014557 putative active site [active] 405532014558 catalytic site [active] 405532014559 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405532014560 PLD-like domain; Region: PLDc_2; pfam13091 405532014561 putative active site [active] 405532014562 catalytic site [active] 405532014563 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 405532014564 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 405532014565 PAS domain S-box; Region: sensory_box; TIGR00229 405532014566 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405532014567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405532014568 metal binding site [ion binding]; metal-binding site 405532014569 active site 405532014570 I-site; other site 405532014571 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405532014572 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 405532014573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405532014574 non-specific DNA binding site [nucleotide binding]; other site 405532014575 salt bridge; other site 405532014576 sequence-specific DNA binding site [nucleotide binding]; other site 405532014577 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405532014578 TPR repeat; Region: TPR_11; pfam13414 405532014579 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405532014580 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405532014581 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405532014582 active site 405532014583 Zn binding site [ion binding]; other site 405532014584 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405532014585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532014586 active site 405532014587 phosphorylation site [posttranslational modification] 405532014588 intermolecular recognition site; other site 405532014589 dimerization interface [polypeptide binding]; other site 405532014590 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405532014591 DNA binding residues [nucleotide binding] 405532014592 dimerization interface [polypeptide binding]; other site 405532014593 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405532014594 Histidine kinase; Region: HisKA_3; pfam07730 405532014595 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405532014596 ATP binding site [chemical binding]; other site 405532014597 Mg2+ binding site [ion binding]; other site 405532014598 G-X-G motif; other site 405532014599 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405532014600 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405532014601 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532014602 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405532014603 Walker A/P-loop; other site 405532014604 ATP binding site [chemical binding]; other site 405532014605 Q-loop/lid; other site 405532014606 ABC transporter signature motif; other site 405532014607 Walker B; other site 405532014608 D-loop; other site 405532014609 H-loop/switch region; other site 405532014610 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405532014611 active site 405532014612 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405532014613 Collagen binding domain; Region: Collagen_bind; pfam05737 405532014614 Collagen binding domain; Region: Collagen_bind; pfam05737 405532014615 Collagen binding domain; Region: Collagen_bind; pfam05737 405532014616 Collagen binding domain; Region: Collagen_bind; pfam05737 405532014617 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014618 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014619 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014620 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014621 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014622 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014623 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014624 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405532014625 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014626 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014627 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014628 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014629 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405532014630 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014631 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014632 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014633 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014634 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014635 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405532014636 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014637 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014638 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014639 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014640 Cna protein B-type domain; Region: Cna_B; pfam05738 405532014641 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405532014642 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 405532014643 PA/protease or protease-like domain interface [polypeptide binding]; other site 405532014644 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 405532014645 Peptidase family M28; Region: Peptidase_M28; pfam04389 405532014646 metal binding site [ion binding]; metal-binding site 405532014647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405532014648 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 405532014649 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405532014650 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405532014651 active site 405532014652 HIGH motif; other site 405532014653 KMSK motif region; other site 405532014654 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405532014655 tRNA binding surface [nucleotide binding]; other site 405532014656 anticodon binding site; other site 405532014657 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 405532014658 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405532014659 putative dimer interface [polypeptide binding]; other site 405532014660 catalytic triad [active] 405532014661 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405532014662 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 405532014663 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 405532014664 agmatinase; Region: agmatinase; TIGR01230 405532014665 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 405532014666 putative active site [active] 405532014667 Mn binding site [ion binding]; other site 405532014668 spermidine synthase; Provisional; Region: PRK00811 405532014669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532014670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532014671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405532014672 putative substrate translocation pore; other site 405532014673 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405532014674 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 405532014675 DNA binding residues [nucleotide binding] 405532014676 putative dimer interface [polypeptide binding]; other site 405532014677 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405532014678 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 405532014679 active site 405532014680 catalytic site [active] 405532014681 metal binding site [ion binding]; metal-binding site 405532014682 dimer interface [polypeptide binding]; other site 405532014683 Transglycosylase; Region: Transgly; pfam00912 405532014684 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405532014685 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405532014686 YwhD family; Region: YwhD; pfam08741 405532014687 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 405532014688 Peptidase family M50; Region: Peptidase_M50; pfam02163 405532014689 active site 405532014690 putative substrate binding region [chemical binding]; other site 405532014691 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 405532014692 active site 1 [active] 405532014693 dimer interface [polypeptide binding]; other site 405532014694 hexamer interface [polypeptide binding]; other site 405532014695 active site 2 [active] 405532014696 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 405532014697 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405532014698 Zn2+ binding site [ion binding]; other site 405532014699 Mg2+ binding site [ion binding]; other site 405532014700 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405532014701 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405532014702 intersubunit interface [polypeptide binding]; other site 405532014703 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405532014704 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405532014705 Walker A/P-loop; other site 405532014706 ATP binding site [chemical binding]; other site 405532014707 Q-loop/lid; other site 405532014708 ABC transporter signature motif; other site 405532014709 Walker B; other site 405532014710 D-loop; other site 405532014711 H-loop/switch region; other site 405532014712 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405532014713 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532014714 ABC-ATPase subunit interface; other site 405532014715 dimer interface [polypeptide binding]; other site 405532014716 putative PBP binding regions; other site 405532014717 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405532014718 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405532014719 ABC-ATPase subunit interface; other site 405532014720 dimer interface [polypeptide binding]; other site 405532014721 putative PBP binding regions; other site 405532014722 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 405532014723 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405532014724 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405532014725 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405532014726 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 405532014727 putative heme peroxidase; Provisional; Region: PRK12276 405532014728 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405532014729 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405532014730 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405532014731 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 405532014732 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405532014733 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 405532014734 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 405532014735 Ion channel; Region: Ion_trans_2; pfam07885 405532014736 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405532014737 TrkA-N domain; Region: TrkA_N; pfam02254 405532014738 TrkA-C domain; Region: TrkA_C; pfam02080 405532014739 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405532014740 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405532014741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532014742 motif II; other site 405532014743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532014744 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 405532014745 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 405532014746 ligand binding site [chemical binding]; other site 405532014747 active site 405532014748 UGI interface [polypeptide binding]; other site 405532014749 catalytic site [active] 405532014750 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405532014751 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 405532014752 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 405532014753 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405532014754 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405532014755 Walker A/P-loop; other site 405532014756 ATP binding site [chemical binding]; other site 405532014757 Q-loop/lid; other site 405532014758 ABC transporter signature motif; other site 405532014759 Walker B; other site 405532014760 D-loop; other site 405532014761 H-loop/switch region; other site 405532014762 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 405532014763 active site 405532014764 catalytic triad [active] 405532014765 oxyanion hole [active] 405532014766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405532014767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405532014768 DNA binding site [nucleotide binding] 405532014769 domain linker motif; other site 405532014770 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405532014771 putative dimerization interface [polypeptide binding]; other site 405532014772 putative ligand binding site [chemical binding]; other site 405532014773 Predicted membrane protein [Function unknown]; Region: COG2364 405532014774 homoserine dehydrogenase; Provisional; Region: PRK06349 405532014775 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405532014776 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405532014777 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 405532014778 Homoserine O-succinyltransferase; Region: HTS; pfam04204 405532014779 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 405532014780 proposed active site lysine [active] 405532014781 conserved cys residue [active] 405532014782 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 405532014783 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405532014784 homodimer interface [polypeptide binding]; other site 405532014785 substrate-cofactor binding pocket; other site 405532014786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405532014787 catalytic residue [active] 405532014788 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 405532014789 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 405532014790 Cl- selectivity filter; other site 405532014791 Cl- binding residues [ion binding]; other site 405532014792 pore gating glutamate residue; other site 405532014793 dimer interface [polypeptide binding]; other site 405532014794 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 405532014795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405532014796 motif I; other site 405532014797 motif II; other site 405532014798 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405532014799 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405532014800 ligand binding site [chemical binding]; other site 405532014801 flexible hinge region; other site 405532014802 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405532014803 azoreductase; Provisional; Region: PRK13556 405532014804 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405532014805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532014806 active site 405532014807 phosphorylation site [posttranslational modification] 405532014808 intermolecular recognition site; other site 405532014809 dimerization interface [polypeptide binding]; other site 405532014810 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405532014811 DNA binding residues [nucleotide binding] 405532014812 dimerization interface [polypeptide binding]; other site 405532014813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405532014814 GAF domain; Region: GAF; pfam01590 405532014815 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405532014816 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405532014817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405532014818 Histidine kinase; Region: HisKA_3; pfam07730 405532014819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532014820 ATP binding site [chemical binding]; other site 405532014821 Mg2+ binding site [ion binding]; other site 405532014822 G-X-G motif; other site 405532014823 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405532014824 dimer interface [polypeptide binding]; other site 405532014825 substrate binding site [chemical binding]; other site 405532014826 ATP binding site [chemical binding]; other site 405532014827 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405532014828 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405532014829 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405532014830 metal binding site [ion binding]; metal-binding site 405532014831 active site 405532014832 I-site; other site 405532014833 Protein of unknown function (DUF466); Region: DUF466; pfam04328 405532014834 carbon starvation protein A; Provisional; Region: PRK15015 405532014835 Carbon starvation protein CstA; Region: CstA; pfam02554 405532014836 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 405532014837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532014838 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405532014839 active site 405532014840 phosphorylation site [posttranslational modification] 405532014841 intermolecular recognition site; other site 405532014842 dimerization interface [polypeptide binding]; other site 405532014843 LytTr DNA-binding domain; Region: LytTR; pfam04397 405532014844 benzoate transport; Region: 2A0115; TIGR00895 405532014845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532014846 putative substrate translocation pore; other site 405532014847 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405532014848 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405532014849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405532014850 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405532014851 Predicted membrane protein [Function unknown]; Region: COG2860 405532014852 UPF0126 domain; Region: UPF0126; pfam03458 405532014853 UPF0126 domain; Region: UPF0126; pfam03458 405532014854 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 405532014855 heme-binding site [chemical binding]; other site 405532014856 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405532014857 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405532014858 dimer interface [polypeptide binding]; other site 405532014859 putative CheW interface [polypeptide binding]; other site 405532014860 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 405532014861 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 405532014862 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405532014863 active site 405532014864 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405532014865 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405532014866 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 405532014867 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 405532014868 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 405532014869 Ligand binding site; other site 405532014870 Putative Catalytic site; other site 405532014871 DXD motif; other site 405532014872 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405532014873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532014874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532014875 ABC transporter; Region: ABC_tran_2; pfam12848 405532014876 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405532014877 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 405532014878 DHHW protein; Region: DHHW; pfam14286 405532014879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405532014880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405532014881 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 405532014882 Protein export membrane protein; Region: SecD_SecF; cl14618 405532014883 methionine sulfoxide reductase A; Provisional; Region: PRK14054 405532014884 methionine sulfoxide reductase B; Provisional; Region: PRK00222 405532014885 SelR domain; Region: SelR; pfam01641 405532014886 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405532014887 antiholin-like protein LrgB; Provisional; Region: PRK04288 405532014888 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 405532014889 two-component response regulator; Provisional; Region: PRK14084 405532014890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532014891 active site 405532014892 phosphorylation site [posttranslational modification] 405532014893 intermolecular recognition site; other site 405532014894 dimerization interface [polypeptide binding]; other site 405532014895 LytTr DNA-binding domain; Region: LytTR; pfam04397 405532014896 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 405532014897 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405532014898 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405532014899 Histidine kinase; Region: His_kinase; pfam06580 405532014900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532014901 ATP binding site [chemical binding]; other site 405532014902 Mg2+ binding site [ion binding]; other site 405532014903 G-X-G motif; other site 405532014904 PyrR binding site 405532014905 benzoate transport; Region: 2A0115; TIGR00895 405532014906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405532014907 putative substrate translocation pore; other site 405532014908 BCCT family transporter; Region: BCCT; pfam02028 405532014909 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 405532014910 active site 405532014911 dimer interface [polypeptide binding]; other site 405532014912 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405532014913 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405532014914 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405532014915 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405532014916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405532014917 NAD(P) binding site [chemical binding]; other site 405532014918 active site 405532014919 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 405532014920 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405532014921 UDP-glucose 4-epimerase; Region: PLN02240 405532014922 NAD binding site [chemical binding]; other site 405532014923 homodimer interface [polypeptide binding]; other site 405532014924 active site 405532014925 substrate binding site [chemical binding]; other site 405532014926 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405532014927 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 405532014928 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 405532014929 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 405532014930 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405532014931 ATP binding site [chemical binding]; other site 405532014932 Mg++ binding site [ion binding]; other site 405532014933 motif III; other site 405532014934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405532014935 nucleotide binding region [chemical binding]; other site 405532014936 ATP-binding site [chemical binding]; other site 405532014937 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 405532014938 RNA binding site [nucleotide binding]; other site 405532014939 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 405532014940 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405532014941 active site 405532014942 oligoendopeptidase F; Region: pepF; TIGR00181 405532014943 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 405532014944 active site 405532014945 Zn binding site [ion binding]; other site 405532014946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405532014947 FeS/SAM binding site; other site 405532014948 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 405532014949 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405532014950 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405532014951 GAF domain; Region: GAF_2; pfam13185 405532014952 GAF domain; Region: GAF_3; pfam13492 405532014953 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405532014954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532014955 putative active site [active] 405532014956 heme pocket [chemical binding]; other site 405532014957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532014958 dimer interface [polypeptide binding]; other site 405532014959 phosphorylation site [posttranslational modification] 405532014960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532014961 ATP binding site [chemical binding]; other site 405532014962 Mg2+ binding site [ion binding]; other site 405532014963 G-X-G motif; other site 405532014964 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 405532014965 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 405532014966 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 405532014967 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405532014968 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405532014969 protein binding site [polypeptide binding]; other site 405532014970 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 405532014971 YycH protein; Region: YycI; pfam09648 405532014972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 405532014973 YycH protein; Region: YycH; pfam07435 405532014974 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405532014975 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 405532014976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405532014977 dimerization interface [polypeptide binding]; other site 405532014978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405532014979 putative active site [active] 405532014980 heme pocket [chemical binding]; other site 405532014981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405532014982 dimer interface [polypeptide binding]; other site 405532014983 phosphorylation site [posttranslational modification] 405532014984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405532014985 ATP binding site [chemical binding]; other site 405532014986 Mg2+ binding site [ion binding]; other site 405532014987 G-X-G motif; other site 405532014988 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405532014989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405532014990 active site 405532014991 phosphorylation site [posttranslational modification] 405532014992 intermolecular recognition site; other site 405532014993 dimerization interface [polypeptide binding]; other site 405532014994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405532014995 DNA binding site [nucleotide binding] 405532014996 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 405532014997 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 405532014998 GDP-binding site [chemical binding]; other site 405532014999 ACT binding site; other site 405532015000 IMP binding site; other site 405532015001 replicative DNA helicase; Provisional; Region: PRK05748 405532015002 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405532015003 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405532015004 Walker A motif; other site 405532015005 ATP binding site [chemical binding]; other site 405532015006 Walker B motif; other site 405532015007 DNA binding loops [nucleotide binding] 405532015008 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 405532015009 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 405532015010 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 405532015011 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 405532015012 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 405532015013 DHH family; Region: DHH; pfam01368 405532015014 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 405532015015 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 405532015016 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405532015017 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405532015018 dimer interface [polypeptide binding]; other site 405532015019 ssDNA binding site [nucleotide binding]; other site 405532015020 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405532015021 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 405532015022 GTP-binding protein YchF; Reviewed; Region: PRK09601 405532015023 YchF GTPase; Region: YchF; cd01900 405532015024 G1 box; other site 405532015025 GTP/Mg2+ binding site [chemical binding]; other site 405532015026 Switch I region; other site 405532015027 G2 box; other site 405532015028 Switch II region; other site 405532015029 G3 box; other site 405532015030 G4 box; other site 405532015031 G5 box; other site 405532015032 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 405532015033 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 405532015034 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405532015035 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405532015036 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 405532015037 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 405532015038 ParB-like nuclease domain; Region: ParB; smart00470 405532015039 KorB domain; Region: KorB; pfam08535 405532015040 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 405532015041 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405532015042 P-loop; other site 405532015043 Magnesium ion binding site [ion binding]; other site 405532015044 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405532015045 Magnesium ion binding site [ion binding]; other site 405532015046 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 405532015047 ParB-like nuclease domain; Region: ParBc; pfam02195 405532015048 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 405532015049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405532015050 S-adenosylmethionine binding site [chemical binding]; other site 405532015051 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 405532015052 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 405532015053 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 405532015054 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 405532015055 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 405532015056 trmE is a tRNA modification GTPase; Region: trmE; cd04164 405532015057 G1 box; other site 405532015058 GTP/Mg2+ binding site [chemical binding]; other site 405532015059 Switch I region; other site 405532015060 G2 box; other site 405532015061 Switch II region; other site 405532015062 G3 box; other site 405532015063 G4 box; other site 405532015064 G5 box; other site 405532015065 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 405532015066 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 405532015067 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 405532015068 G-X-X-G motif; other site 405532015069 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 405532015070 RxxxH motif; other site 405532015071 OxaA-like protein precursor; Validated; Region: PRK02944 405532015072 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 405532015073 ribonuclease P; Reviewed; Region: rnpA; PRK00499 405532015074 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399