-- dump date 20140618_214417 -- class Genbank::misc_feature -- table misc_feature_note -- id note 226900000001 Helix-turn-helix domain; Region: HTH_17; pfam12728 226900000002 hypothetical protein; Region: PHA01548 226900000003 DNA polymerase; Provisional; Region: PHA02563 226900000004 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 226900000005 AAA-like domain; Region: AAA_10; pfam12846 226900000006 YvrJ protein family; Region: YvrJ; pfam12841 226900000007 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 226900000008 Peptidase M15; Region: Peptidase_M15_3; cl01194 226900000009 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 226900000010 active site 226900000011 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900000012 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 226900000013 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 226900000014 DnaA N-terminal domain; Region: DnaA_N; pfam11638 226900000015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000016 Walker A motif; other site 226900000017 ATP binding site [chemical binding]; other site 226900000018 Walker B motif; other site 226900000019 arginine finger; other site 226900000020 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 226900000021 DnaA box-binding interface [nucleotide binding]; other site 226900000022 DNA polymerase III subunit beta; Validated; Region: PRK05643 226900000023 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 226900000024 putative DNA binding surface [nucleotide binding]; other site 226900000025 dimer interface [polypeptide binding]; other site 226900000026 beta-clamp/clamp loader binding surface; other site 226900000027 beta-clamp/translesion DNA polymerase binding surface; other site 226900000028 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 226900000029 recombination protein F; Reviewed; Region: recF; PRK00064 226900000030 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 226900000031 Walker A/P-loop; other site 226900000032 ATP binding site [chemical binding]; other site 226900000033 Q-loop/lid; other site 226900000034 ABC transporter signature motif; other site 226900000035 Walker B; other site 226900000036 D-loop; other site 226900000037 H-loop/switch region; other site 226900000038 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 226900000039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900000040 ATP binding site [chemical binding]; other site 226900000041 Mg2+ binding site [ion binding]; other site 226900000042 G-X-G motif; other site 226900000043 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 226900000044 anchoring element; other site 226900000045 dimer interface [polypeptide binding]; other site 226900000046 ATP binding site [chemical binding]; other site 226900000047 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 226900000048 active site 226900000049 putative metal-binding site [ion binding]; other site 226900000050 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 226900000051 DNA gyrase subunit A; Validated; Region: PRK05560 226900000052 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 226900000053 CAP-like domain; other site 226900000054 active site 226900000055 primary dimer interface [polypeptide binding]; other site 226900000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900000062 YaaC-like Protein; Region: YaaC; pfam14175 226900000063 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 226900000064 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 226900000065 active site 226900000066 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 226900000067 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900000068 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 226900000069 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 226900000070 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 226900000071 active site 226900000072 multimer interface [polypeptide binding]; other site 226900000073 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 226900000074 predicted active site [active] 226900000075 catalytic triad [active] 226900000076 seryl-tRNA synthetase; Provisional; Region: PRK05431 226900000077 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 226900000078 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 226900000079 dimer interface [polypeptide binding]; other site 226900000080 active site 226900000081 motif 1; other site 226900000082 motif 2; other site 226900000083 motif 3; other site 226900000084 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 226900000085 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 226900000086 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226900000087 DNA binding residues [nucleotide binding] 226900000088 similar to Deoxyadenosine kinase; EC_number 2.7.1.76 226900000089 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 226900000090 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 226900000091 Substrate-binding site [chemical binding]; other site 226900000092 Substrate specificity [chemical binding]; other site 226900000093 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 226900000094 catalytic triad [active] 226900000095 conserved cis-peptide bond; other site 226900000096 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 226900000097 nucleoside/Zn binding site; other site 226900000098 dimer interface [polypeptide binding]; other site 226900000099 catalytic motif [active] 226900000100 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 226900000101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000102 Walker A motif; other site 226900000103 ATP binding site [chemical binding]; other site 226900000104 Walker B motif; other site 226900000105 arginine finger; other site 226900000106 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 226900000107 hypothetical protein; Validated; Region: PRK00153 226900000108 recombination protein RecR; Reviewed; Region: recR; PRK00076 226900000109 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 226900000110 RecR protein; Region: RecR; pfam02132 226900000111 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 226900000112 putative active site [active] 226900000113 putative metal-binding site [ion binding]; other site 226900000114 tetramer interface [polypeptide binding]; other site 226900000115 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 226900000116 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 226900000117 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 226900000118 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 226900000119 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 226900000120 homodimer interface [polypeptide binding]; other site 226900000121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900000122 catalytic residue [active] 226900000123 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 226900000124 thymidylate kinase; Validated; Region: tmk; PRK00698 226900000125 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 226900000126 TMP-binding site; other site 226900000127 ATP-binding site [chemical binding]; other site 226900000128 DNA polymerase III subunit delta'; Validated; Region: PRK08058 226900000129 DNA polymerase III subunit delta'; Validated; Region: PRK08485 226900000130 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 226900000131 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 226900000132 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 226900000133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000134 S-adenosylmethionine binding site [chemical binding]; other site 226900000135 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 226900000136 putative SAM binding site [chemical binding]; other site 226900000137 putative homodimer interface [polypeptide binding]; other site 226900000138 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 226900000139 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 226900000140 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 226900000141 active site 226900000142 HIGH motif; other site 226900000143 KMSKS motif; other site 226900000144 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 226900000145 tRNA binding surface [nucleotide binding]; other site 226900000146 anticodon binding site; other site 226900000147 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 226900000148 dimer interface [polypeptide binding]; other site 226900000149 putative tRNA-binding site [nucleotide binding]; other site 226900000150 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 226900000151 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 226900000152 active site 226900000153 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 226900000154 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 226900000155 putative active site [active] 226900000156 putative metal binding site [ion binding]; other site 226900000157 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 226900000158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000159 S-adenosylmethionine binding site [chemical binding]; other site 226900000160 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 226900000161 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 226900000162 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900000163 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 226900000164 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226900000165 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226900000166 pur operon repressor; Provisional; Region: PRK09213 226900000167 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 226900000168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900000169 active site 226900000170 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226900000171 homotrimer interaction site [polypeptide binding]; other site 226900000172 putative active site [active] 226900000173 regulatory protein SpoVG; Reviewed; Region: PRK13259 226900000174 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 226900000175 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 226900000176 Substrate binding site; other site 226900000177 Mg++ binding site; other site 226900000178 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 226900000179 active site 226900000180 substrate binding site [chemical binding]; other site 226900000181 CoA binding site [chemical binding]; other site 226900000182 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 226900000183 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 226900000184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900000185 active site 226900000186 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 226900000187 putative active site [active] 226900000188 catalytic residue [active] 226900000189 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 226900000190 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 226900000191 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 226900000192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900000193 ATP binding site [chemical binding]; other site 226900000194 putative Mg++ binding site [ion binding]; other site 226900000195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900000196 nucleotide binding region [chemical binding]; other site 226900000197 ATP-binding site [chemical binding]; other site 226900000198 TRCF domain; Region: TRCF; pfam03461 226900000199 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 226900000200 stage V sporulation protein T; Region: spore_V_T; TIGR02851 226900000201 stage V sporulation protein B; Region: spore_V_B; TIGR02900 226900000202 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 226900000203 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 226900000204 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 226900000205 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 226900000206 putative SAM binding site [chemical binding]; other site 226900000207 putative homodimer interface [polypeptide binding]; other site 226900000208 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 226900000209 homodimer interface [polypeptide binding]; other site 226900000210 metal binding site [ion binding]; metal-binding site 226900000211 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 226900000212 homodimer interface [polypeptide binding]; other site 226900000213 active site 226900000214 putative chemical substrate binding site [chemical binding]; other site 226900000215 metal binding site [ion binding]; metal-binding site 226900000216 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900000217 RNA binding surface [nucleotide binding]; other site 226900000218 sporulation protein YabP; Region: spore_yabP; TIGR02892 226900000219 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 226900000220 Septum formation initiator; Region: DivIC; pfam04977 226900000221 hypothetical protein; Provisional; Region: PRK08582 226900000222 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 226900000223 RNA binding site [nucleotide binding]; other site 226900000224 stage II sporulation protein E; Region: spore_II_E; TIGR02865 226900000225 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 226900000226 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 226900000227 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 226900000228 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 226900000229 Ligand Binding Site [chemical binding]; other site 226900000230 TilS substrate binding domain; Region: TilS; pfam09179 226900000231 TilS substrate C-terminal domain; Region: TilS_C; smart00977 226900000232 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900000233 active site 226900000234 FtsH Extracellular; Region: FtsH_ext; pfam06480 226900000235 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 226900000236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000237 Walker A motif; other site 226900000238 ATP binding site [chemical binding]; other site 226900000239 Walker B motif; other site 226900000240 arginine finger; other site 226900000241 Peptidase family M41; Region: Peptidase_M41; pfam01434 226900000242 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226900000243 nucleotide binding site [chemical binding]; other site 226900000244 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 226900000245 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 226900000246 dimerization interface [polypeptide binding]; other site 226900000247 domain crossover interface; other site 226900000248 redox-dependent activation switch; other site 226900000249 cysteine synthase; Region: PLN02565 226900000250 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226900000251 dimer interface [polypeptide binding]; other site 226900000252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900000253 catalytic residue [active] 226900000254 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 226900000255 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 226900000256 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 226900000257 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 226900000258 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 226900000259 glutamine binding [chemical binding]; other site 226900000260 catalytic triad [active] 226900000261 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 226900000262 homodimer interface [polypeptide binding]; other site 226900000263 substrate-cofactor binding pocket; other site 226900000264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900000265 catalytic residue [active] 226900000266 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 226900000267 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 226900000268 substrate binding pocket [chemical binding]; other site 226900000269 dimer interface [polypeptide binding]; other site 226900000270 inhibitor binding site; inhibition site 226900000271 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 226900000272 homooctamer interface [polypeptide binding]; other site 226900000273 active site 226900000274 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 226900000275 catalytic center binding site [active] 226900000276 ATP binding site [chemical binding]; other site 226900000277 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900000278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900000279 non-specific DNA binding site [nucleotide binding]; other site 226900000280 salt bridge; other site 226900000281 sequence-specific DNA binding site [nucleotide binding]; other site 226900000282 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 226900000283 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 226900000284 FMN binding site [chemical binding]; other site 226900000285 active site 226900000286 catalytic residues [active] 226900000287 substrate binding site [chemical binding]; other site 226900000288 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 226900000289 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 226900000290 dimer interface [polypeptide binding]; other site 226900000291 putative anticodon binding site; other site 226900000292 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 226900000293 motif 1; other site 226900000294 active site 226900000295 motif 2; other site 226900000296 motif 3; other site 226900000297 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 226900000298 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 226900000299 UvrB/uvrC motif; Region: UVR; pfam02151 226900000300 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 226900000301 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 226900000302 ADP binding site [chemical binding]; other site 226900000303 phosphagen binding site; other site 226900000304 substrate specificity loop; other site 226900000305 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 226900000306 Clp amino terminal domain; Region: Clp_N; pfam02861 226900000307 Clp amino terminal domain; Region: Clp_N; pfam02861 226900000308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000309 Walker A motif; other site 226900000310 ATP binding site [chemical binding]; other site 226900000311 Walker B motif; other site 226900000312 arginine finger; other site 226900000313 UvrB/uvrC motif; Region: UVR; pfam02151 226900000314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900000315 Walker A motif; other site 226900000316 ATP binding site [chemical binding]; other site 226900000317 Walker B motif; other site 226900000318 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 226900000319 DNA repair protein RadA; Provisional; Region: PRK11823 226900000320 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 226900000321 Walker A motif/ATP binding site; other site 226900000322 ATP binding site [chemical binding]; other site 226900000323 Walker B motif; other site 226900000324 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 226900000325 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 226900000326 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 226900000327 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 226900000328 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226900000329 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 226900000330 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 226900000331 putative active site [active] 226900000332 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 226900000333 substrate binding site; other site 226900000334 dimer interface; other site 226900000335 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 226900000336 homotrimer interaction site [polypeptide binding]; other site 226900000337 zinc binding site [ion binding]; other site 226900000338 CDP-binding sites; other site 226900000339 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 226900000340 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 226900000341 active site 226900000342 HIGH motif; other site 226900000343 KMSKS motif; other site 226900000344 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 226900000345 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 226900000346 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 226900000347 trimer interface [polypeptide binding]; other site 226900000348 active site 226900000349 substrate binding site [chemical binding]; other site 226900000350 CoA binding site [chemical binding]; other site 226900000351 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 226900000352 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 226900000353 active site 226900000354 HIGH motif; other site 226900000355 KMSKS motif; other site 226900000356 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 226900000357 tRNA binding surface [nucleotide binding]; other site 226900000358 anticodon binding site; other site 226900000359 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 226900000360 active site 226900000361 metal binding site [ion binding]; metal-binding site 226900000362 dimerization interface [polypeptide binding]; other site 226900000363 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 226900000364 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 226900000365 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 226900000366 YacP-like NYN domain; Region: NYN_YacP; pfam05991 226900000367 RNA polymerase factor sigma-70; Validated; Region: PRK08295 226900000368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900000369 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226900000370 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 226900000371 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 226900000372 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 226900000373 putative homodimer interface [polypeptide binding]; other site 226900000374 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 226900000375 heterodimer interface [polypeptide binding]; other site 226900000376 homodimer interface [polypeptide binding]; other site 226900000377 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 226900000378 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 226900000379 23S rRNA interface [nucleotide binding]; other site 226900000380 L7/L12 interface [polypeptide binding]; other site 226900000381 putative thiostrepton binding site; other site 226900000382 L25 interface [polypeptide binding]; other site 226900000383 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 226900000384 mRNA/rRNA interface [nucleotide binding]; other site 226900000385 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 226900000386 23S rRNA interface [nucleotide binding]; other site 226900000387 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 226900000388 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 226900000389 core dimer interface [polypeptide binding]; other site 226900000390 peripheral dimer interface [polypeptide binding]; other site 226900000391 L10 interface [polypeptide binding]; other site 226900000392 L11 interface [polypeptide binding]; other site 226900000393 putative EF-Tu interaction site [polypeptide binding]; other site 226900000394 putative EF-G interaction site [polypeptide binding]; other site 226900000395 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 226900000396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000397 S-adenosylmethionine binding site [chemical binding]; other site 226900000398 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 226900000399 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 226900000400 RPB12 interaction site [polypeptide binding]; other site 226900000401 RPB1 interaction site [polypeptide binding]; other site 226900000402 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 226900000403 RPB10 interaction site [polypeptide binding]; other site 226900000404 RPB11 interaction site [polypeptide binding]; other site 226900000405 RPB3 interaction site [polypeptide binding]; other site 226900000406 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 226900000407 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 226900000408 beta and beta' interface [polypeptide binding]; other site 226900000409 beta' and sigma factor interface [polypeptide binding]; other site 226900000410 Zn-binding [ion binding]; other site 226900000411 active site region [active] 226900000412 catalytic site [active] 226900000413 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 226900000414 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 226900000415 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 226900000416 G-loop; other site 226900000417 DNA binding site [nucleotide binding] 226900000418 hypothetical protein; Provisional; Region: PRK06683 226900000419 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 226900000420 S17 interaction site [polypeptide binding]; other site 226900000421 S8 interaction site; other site 226900000422 16S rRNA interaction site [nucleotide binding]; other site 226900000423 streptomycin interaction site [chemical binding]; other site 226900000424 23S rRNA interaction site [nucleotide binding]; other site 226900000425 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 226900000426 30S ribosomal protein S7; Validated; Region: PRK05302 226900000427 similar to hypothetical protein 226900000428 elongation factor G; Reviewed; Region: PRK00007 226900000429 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 226900000430 G1 box; other site 226900000431 putative GEF interaction site [polypeptide binding]; other site 226900000432 GTP/Mg2+ binding site [chemical binding]; other site 226900000433 Switch I region; other site 226900000434 G2 box; other site 226900000435 G3 box; other site 226900000436 Switch II region; other site 226900000437 G4 box; other site 226900000438 G5 box; other site 226900000439 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 226900000440 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226900000441 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 226900000442 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 226900000443 elongation factor Tu; Reviewed; Region: PRK00049 226900000444 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 226900000445 G1 box; other site 226900000446 GEF interaction site [polypeptide binding]; other site 226900000447 GTP/Mg2+ binding site [chemical binding]; other site 226900000448 Switch I region; other site 226900000449 G2 box; other site 226900000450 G3 box; other site 226900000451 Switch II region; other site 226900000452 G4 box; other site 226900000453 G5 box; other site 226900000454 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 226900000455 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 226900000456 Antibiotic Binding Site [chemical binding]; other site 226900000457 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 226900000458 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 226900000459 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 226900000460 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 226900000461 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 226900000462 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 226900000463 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 226900000464 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 226900000465 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 226900000466 putative translocon binding site; other site 226900000467 protein-rRNA interface [nucleotide binding]; other site 226900000468 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 226900000469 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 226900000470 G-X-X-G motif; other site 226900000471 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 226900000472 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 226900000473 23S rRNA interface [nucleotide binding]; other site 226900000474 5S rRNA interface [nucleotide binding]; other site 226900000475 putative antibiotic binding site [chemical binding]; other site 226900000476 L25 interface [polypeptide binding]; other site 226900000477 L27 interface [polypeptide binding]; other site 226900000478 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 226900000479 putative translocon interaction site; other site 226900000480 signal recognition particle (SRP54) interaction site; other site 226900000481 L23 interface [polypeptide binding]; other site 226900000482 trigger factor interaction site; other site 226900000483 23S rRNA interface [nucleotide binding]; other site 226900000484 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 226900000485 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 226900000486 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 226900000487 RNA binding site [nucleotide binding]; other site 226900000488 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 226900000489 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 226900000490 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 226900000491 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 226900000492 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 226900000493 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 226900000494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 226900000495 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 226900000496 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 226900000497 5S rRNA interface [nucleotide binding]; other site 226900000498 L27 interface [polypeptide binding]; other site 226900000499 23S rRNA interface [nucleotide binding]; other site 226900000500 L5 interface [polypeptide binding]; other site 226900000501 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 226900000502 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 226900000503 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 226900000504 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 226900000505 23S rRNA binding site [nucleotide binding]; other site 226900000506 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 226900000507 similar to Protein translocase subunit SecY 226900000508 adenylate kinase; Reviewed; Region: adk; PRK00279 226900000509 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 226900000510 AMP-binding site [chemical binding]; other site 226900000511 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 226900000512 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 226900000513 active site 226900000514 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 226900000515 rRNA binding site [nucleotide binding]; other site 226900000516 predicted 30S ribosome binding site; other site 226900000517 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 226900000518 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 226900000519 30S ribosomal protein S11; Validated; Region: PRK05309 226900000520 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 226900000521 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 226900000522 alphaNTD - beta interaction site [polypeptide binding]; other site 226900000523 alphaNTD homodimer interface [polypeptide binding]; other site 226900000524 alphaNTD - beta' interaction site [polypeptide binding]; other site 226900000525 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 226900000526 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 226900000527 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 226900000528 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226900000529 Walker A/P-loop; other site 226900000530 ATP binding site [chemical binding]; other site 226900000531 Q-loop/lid; other site 226900000532 ABC transporter signature motif; other site 226900000533 Walker B; other site 226900000534 D-loop; other site 226900000535 H-loop/switch region; other site 226900000536 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 226900000537 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226900000538 Walker A/P-loop; other site 226900000539 ATP binding site [chemical binding]; other site 226900000540 Q-loop/lid; other site 226900000541 ABC transporter signature motif; other site 226900000542 Walker B; other site 226900000543 D-loop; other site 226900000544 H-loop/switch region; other site 226900000545 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 226900000546 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 226900000547 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 226900000548 dimerization interface 3.5A [polypeptide binding]; other site 226900000549 active site 226900000550 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 226900000551 23S rRNA interface [nucleotide binding]; other site 226900000552 L3 interface [polypeptide binding]; other site 226900000553 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 226900000554 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 226900000555 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 226900000556 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900000557 active site 226900000558 metal binding site [ion binding]; metal-binding site 226900000559 Domain of unknown function DUF59; Region: DUF59; cl00941 226900000560 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 226900000561 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 226900000562 Walker A motif; other site 226900000563 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 226900000564 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226900000565 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 226900000566 NodB motif; other site 226900000567 putative active site [active] 226900000568 putative catalytic site [active] 226900000569 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 226900000570 Arginase family; Region: Arginase; cd09989 226900000571 active site 226900000572 Mn binding site [ion binding]; other site 226900000573 oligomer interface [polypeptide binding]; other site 226900000574 Uncharacterized conserved protein [Function unknown]; Region: COG1624 226900000575 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 226900000576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 226900000577 YbbR-like protein; Region: YbbR; pfam07949 226900000578 YbbR-like protein; Region: YbbR; pfam07949 226900000579 YbbR-like protein; Region: YbbR; pfam07949 226900000580 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 226900000581 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 226900000582 active site 226900000583 substrate binding site [chemical binding]; other site 226900000584 metal binding site [ion binding]; metal-binding site 226900000585 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 226900000586 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 226900000587 glutaminase active site [active] 226900000588 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 226900000589 dimer interface [polypeptide binding]; other site 226900000590 active site 226900000591 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 226900000592 dimer interface [polypeptide binding]; other site 226900000593 active site 226900000594 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 226900000595 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 226900000596 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 226900000597 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 226900000598 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 226900000599 Predicted membrane protein [Function unknown]; Region: COG2259 226900000600 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 226900000601 classical (c) SDRs; Region: SDR_c; cd05233 226900000602 NAD(P) binding site [chemical binding]; other site 226900000603 active site 226900000604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000605 dimer interface [polypeptide binding]; other site 226900000606 conserved gate region; other site 226900000607 putative PBP binding loops; other site 226900000608 ABC-ATPase subunit interface; other site 226900000609 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 226900000610 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 226900000611 Walker A/P-loop; other site 226900000612 ATP binding site [chemical binding]; other site 226900000613 Q-loop/lid; other site 226900000614 ABC transporter signature motif; other site 226900000615 Walker B; other site 226900000616 D-loop; other site 226900000617 H-loop/switch region; other site 226900000618 NIL domain; Region: NIL; pfam09383 226900000619 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 226900000620 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900000621 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 226900000622 putative NAD(P) binding site [chemical binding]; other site 226900000623 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 226900000624 FAD binding domain; Region: FAD_binding_4; pfam01565 226900000625 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 226900000626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900000627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900000628 putative substrate translocation pore; other site 226900000629 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 226900000630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900000631 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 226900000632 putative substrate translocation pore; other site 226900000633 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 226900000634 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 226900000635 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900000636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000637 dimer interface [polypeptide binding]; other site 226900000638 conserved gate region; other site 226900000639 putative PBP binding loops; other site 226900000640 ABC-ATPase subunit interface; other site 226900000641 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900000642 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 226900000643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000644 dimer interface [polypeptide binding]; other site 226900000645 conserved gate region; other site 226900000646 putative PBP binding loops; other site 226900000647 ABC-ATPase subunit interface; other site 226900000648 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226900000649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226900000650 Walker A/P-loop; other site 226900000651 ATP binding site [chemical binding]; other site 226900000652 Q-loop/lid; other site 226900000653 ABC transporter signature motif; other site 226900000654 Walker B; other site 226900000655 D-loop; other site 226900000656 H-loop/switch region; other site 226900000657 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900000658 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 226900000659 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226900000660 Walker A/P-loop; other site 226900000661 ATP binding site [chemical binding]; other site 226900000662 Q-loop/lid; other site 226900000663 ABC transporter signature motif; other site 226900000664 Walker B; other site 226900000665 D-loop; other site 226900000666 H-loop/switch region; other site 226900000667 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900000668 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900000669 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900000670 peptide binding site [polypeptide binding]; other site 226900000671 YusW-like protein; Region: YusW; pfam14039 226900000672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900000673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900000674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900000675 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 226900000676 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900000677 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900000678 peptide binding site [polypeptide binding]; other site 226900000679 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900000680 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900000681 peptide binding site [polypeptide binding]; other site 226900000682 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900000683 active site 226900000684 catalytic tetrad [active] 226900000685 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 226900000686 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 226900000687 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 226900000688 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 226900000689 Sugar transport protein; Region: Sugar_transport; pfam06800 226900000690 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 226900000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000692 dimer interface [polypeptide binding]; other site 226900000693 conserved gate region; other site 226900000694 putative PBP binding loops; other site 226900000695 ABC-ATPase subunit interface; other site 226900000696 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 226900000697 DNA binding domain, excisionase family; Region: excise; TIGR01764 226900000698 PBP superfamily domain; Region: PBP_like; pfam12727 226900000699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900000700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900000701 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 226900000702 putative dimerization interface [polypeptide binding]; other site 226900000703 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900000704 EamA-like transporter family; Region: EamA; pfam00892 226900000705 YrzO-like protein; Region: YrzO; pfam14142 226900000706 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 226900000707 putative acyl-acceptor binding pocket; other site 226900000708 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900000709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900000710 DNA binding site [nucleotide binding] 226900000711 domain linker motif; other site 226900000712 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226900000713 putative ligand binding site [chemical binding]; other site 226900000714 putative dimerization interface [polypeptide binding]; other site 226900000715 Bacterial PH domain; Region: bPH_3; pfam14470 226900000716 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900000717 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900000718 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900000719 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226900000720 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 226900000721 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 226900000722 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 226900000723 active site 226900000724 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 226900000725 NodB motif; other site 226900000726 putative active site [active] 226900000727 putative catalytic site [active] 226900000728 putative Zn binding site [ion binding]; other site 226900000729 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 226900000730 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 226900000731 catalytic residue [active] 226900000732 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 226900000733 nucleotide binding site/active site [active] 226900000734 HIT family signature motif; other site 226900000735 catalytic residue [active] 226900000736 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900000737 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900000738 ABC transporter; Region: ABC_tran_2; pfam12848 226900000739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900000740 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 226900000741 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 226900000742 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900000743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000744 dimer interface [polypeptide binding]; other site 226900000745 conserved gate region; other site 226900000746 putative PBP binding loops; other site 226900000747 ABC-ATPase subunit interface; other site 226900000748 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900000749 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 226900000750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900000751 dimer interface [polypeptide binding]; other site 226900000752 conserved gate region; other site 226900000753 putative PBP binding loops; other site 226900000754 ABC-ATPase subunit interface; other site 226900000755 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226900000756 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226900000757 Walker A/P-loop; other site 226900000758 ATP binding site [chemical binding]; other site 226900000759 Q-loop/lid; other site 226900000760 ABC transporter signature motif; other site 226900000761 Walker B; other site 226900000762 D-loop; other site 226900000763 H-loop/switch region; other site 226900000764 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900000765 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 226900000766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226900000767 Walker A/P-loop; other site 226900000768 ATP binding site [chemical binding]; other site 226900000769 Q-loop/lid; other site 226900000770 ABC transporter signature motif; other site 226900000771 Walker B; other site 226900000772 D-loop; other site 226900000773 H-loop/switch region; other site 226900000774 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900000775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900000776 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900000777 active site 226900000778 motif I; other site 226900000779 motif II; other site 226900000780 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900000781 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000782 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000783 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000784 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000785 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 226900000786 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 226900000787 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 226900000788 dimer interface [polypeptide binding]; other site 226900000789 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 226900000790 active site 226900000791 Fe binding site [ion binding]; other site 226900000792 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 226900000793 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 226900000794 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 226900000795 amino acid transporter; Region: 2A0306; TIGR00909 226900000796 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900000797 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 226900000798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900000799 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900000800 putative substrate translocation pore; other site 226900000801 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 226900000802 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 226900000803 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 226900000804 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 226900000805 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226900000806 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226900000807 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900000808 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900000809 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226900000810 ATP binding site [chemical binding]; other site 226900000811 Mg++ binding site [ion binding]; other site 226900000812 motif III; other site 226900000813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900000814 nucleotide binding region [chemical binding]; other site 226900000815 ATP-binding site [chemical binding]; other site 226900000816 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 226900000817 Rhomboid family; Region: Rhomboid; pfam01694 226900000818 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 226900000819 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 226900000820 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 226900000821 alanine racemase; Reviewed; Region: alr; PRK00053 226900000822 active site 226900000823 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900000824 dimer interface [polypeptide binding]; other site 226900000825 substrate binding site [chemical binding]; other site 226900000826 catalytic residues [active] 226900000827 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 226900000828 PemK-like protein; Region: PemK; pfam02452 226900000829 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 226900000830 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 226900000831 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 226900000832 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226900000833 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 226900000834 RNA binding site [nucleotide binding]; other site 226900000835 hypothetical protein; Provisional; Region: PRK04351 226900000836 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 226900000837 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 226900000838 Glycoprotease family; Region: Peptidase_M22; pfam00814 226900000839 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 226900000840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900000841 Coenzyme A binding pocket [chemical binding]; other site 226900000842 UGMP family protein; Validated; Region: PRK09604 226900000843 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 226900000844 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 226900000845 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900000846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900000847 ABC transporter; Region: ABC_tran_2; pfam12848 226900000848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900000849 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 226900000850 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 226900000851 CoA binding domain; Region: CoA_binding; pfam02629 226900000852 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 226900000853 CAAX protease self-immunity; Region: Abi; pfam02517 226900000854 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 226900000855 oligomerisation interface [polypeptide binding]; other site 226900000856 mobile loop; other site 226900000857 roof hairpin; other site 226900000858 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 226900000859 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 226900000860 ring oligomerisation interface [polypeptide binding]; other site 226900000861 ATP/Mg binding site [chemical binding]; other site 226900000862 stacking interactions; other site 226900000863 hinge regions; other site 226900000864 GMP synthase; Reviewed; Region: guaA; PRK00074 226900000865 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 226900000866 AMP/PPi binding site [chemical binding]; other site 226900000867 candidate oxyanion hole; other site 226900000868 catalytic triad [active] 226900000869 potential glutamine specificity residues [chemical binding]; other site 226900000870 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 226900000871 ATP Binding subdomain [chemical binding]; other site 226900000872 Ligand Binding sites [chemical binding]; other site 226900000873 Dimerization subdomain; other site 226900000874 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 226900000875 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900000876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900000877 active site 226900000878 phosphorylation site [posttranslational modification] 226900000879 intermolecular recognition site; other site 226900000880 dimerization interface [polypeptide binding]; other site 226900000881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900000882 DNA binding site [nucleotide binding] 226900000883 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 226900000884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900000885 dimerization interface [polypeptide binding]; other site 226900000886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900000887 dimer interface [polypeptide binding]; other site 226900000888 phosphorylation site [posttranslational modification] 226900000889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900000890 ATP binding site [chemical binding]; other site 226900000891 Mg2+ binding site [ion binding]; other site 226900000892 G-X-G motif; other site 226900000893 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900000894 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226900000895 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226900000896 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 226900000897 catalytic residues [active] 226900000898 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 226900000899 putative ligand binding site [chemical binding]; other site 226900000900 putative catalytic site [active] 226900000901 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900000902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000903 S-adenosylmethionine binding site [chemical binding]; other site 226900000904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000905 S-adenosylmethionine binding site [chemical binding]; other site 226900000906 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 226900000907 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900000908 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 226900000909 putative NAD(P) binding site [chemical binding]; other site 226900000910 active site 226900000911 putative substrate binding site [chemical binding]; other site 226900000912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900000913 S-adenosylmethionine binding site [chemical binding]; other site 226900000914 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226900000915 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226900000916 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900000917 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900000918 active site 226900000919 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900000920 EamA-like transporter family; Region: EamA; pfam00892 226900000921 EamA-like transporter family; Region: EamA; pfam00892 226900000922 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 226900000923 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 226900000924 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 226900000925 ATP-grasp domain; Region: ATP-grasp; pfam02222 226900000926 adenylosuccinate lyase; Provisional; Region: PRK07492 226900000927 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 226900000928 tetramer interface [polypeptide binding]; other site 226900000929 active site 226900000930 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 226900000931 ATP binding site [chemical binding]; other site 226900000932 active site 226900000933 substrate binding site [chemical binding]; other site 226900000934 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 226900000935 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 226900000936 putative active site [active] 226900000937 catalytic triad [active] 226900000938 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 226900000939 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 226900000940 dimerization interface [polypeptide binding]; other site 226900000941 ATP binding site [chemical binding]; other site 226900000942 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 226900000943 dimerization interface [polypeptide binding]; other site 226900000944 ATP binding site [chemical binding]; other site 226900000945 amidophosphoribosyltransferase; Provisional; Region: PRK06781 226900000946 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 226900000947 active site 226900000948 tetramer interface [polypeptide binding]; other site 226900000949 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900000950 active site 226900000951 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 226900000952 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 226900000953 dimerization interface [polypeptide binding]; other site 226900000954 putative ATP binding site [chemical binding]; other site 226900000955 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 226900000956 active site 226900000957 substrate binding site [chemical binding]; other site 226900000958 cosubstrate binding site; other site 226900000959 catalytic site [active] 226900000960 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 226900000961 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 226900000962 purine monophosphate binding site [chemical binding]; other site 226900000963 dimer interface [polypeptide binding]; other site 226900000964 putative catalytic residues [active] 226900000965 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 226900000966 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 226900000967 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 226900000968 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 226900000969 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 226900000970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 226900000971 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u2; cd03402 226900000972 prohibitin homologues; Region: PHB; smart00244 226900000973 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 226900000974 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 226900000975 substrate binding site [chemical binding]; other site 226900000976 putative active site [active] 226900000977 dimer interface [polypeptide binding]; other site 226900000978 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 226900000979 Part of AAA domain; Region: AAA_19; pfam13245 226900000980 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226900000981 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 226900000982 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 226900000983 nucleotide binding pocket [chemical binding]; other site 226900000984 K-X-D-G motif; other site 226900000985 catalytic site [active] 226900000986 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 226900000987 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 226900000988 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226900000989 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 226900000990 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 226900000991 Dimer interface [polypeptide binding]; other site 226900000992 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 226900000993 putative dimer interface [polypeptide binding]; other site 226900000994 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 226900000995 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 226900000996 putative dimer interface [polypeptide binding]; other site 226900000997 hypothetical protein; Provisional; Region: PRK10621 226900000998 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 226900000999 Glutamate binding site [chemical binding]; other site 226900001000 homodimer interface [polypeptide binding]; other site 226900001001 NAD binding site [chemical binding]; other site 226900001002 catalytic residues [active] 226900001003 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900001004 catalytic triad [active] 226900001005 conserved cis-peptide bond; other site 226900001006 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 226900001007 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 226900001008 Walker A/P-loop; other site 226900001009 ATP binding site [chemical binding]; other site 226900001010 Q-loop/lid; other site 226900001011 ABC transporter signature motif; other site 226900001012 Walker B; other site 226900001013 D-loop; other site 226900001014 H-loop/switch region; other site 226900001015 NIL domain; Region: NIL; pfam09383 226900001016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001017 dimer interface [polypeptide binding]; other site 226900001018 conserved gate region; other site 226900001019 putative PBP binding loops; other site 226900001020 ABC-ATPase subunit interface; other site 226900001021 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 226900001022 yiaA/B two helix domain; Region: YiaAB; pfam05360 226900001023 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 226900001024 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 226900001025 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 226900001026 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 226900001027 GatB domain; Region: GatB_Yqey; pfam02637 226900001028 putative lipid kinase; Reviewed; Region: PRK13337 226900001029 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 226900001030 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226900001031 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 226900001032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900001033 motif II; other site 226900001034 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900001035 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 226900001036 inhibitor-cofactor binding pocket; inhibition site 226900001037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900001038 catalytic residue [active] 226900001039 PAS domain; Region: PAS_9; pfam13426 226900001040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900001041 putative active site [active] 226900001042 heme pocket [chemical binding]; other site 226900001043 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 226900001044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900001045 Walker A motif; other site 226900001046 ATP binding site [chemical binding]; other site 226900001047 Walker B motif; other site 226900001048 arginine finger; other site 226900001049 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 226900001050 tetramerization interface [polypeptide binding]; other site 226900001051 NAD(P) binding site [chemical binding]; other site 226900001052 catalytic residues [active] 226900001053 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 226900001054 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 226900001055 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 226900001056 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226900001057 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 226900001058 putative active site [active] 226900001059 putative metal binding site [ion binding]; other site 226900001060 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900001061 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900001062 Nucleoside recognition; Region: Gate; pfam07670 226900001063 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900001064 TRAM domain; Region: TRAM; cl01282 226900001065 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 226900001066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900001067 S-adenosylmethionine binding site [chemical binding]; other site 226900001068 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 226900001069 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 226900001070 FMN binding site [chemical binding]; other site 226900001071 active site 226900001072 catalytic residues [active] 226900001073 substrate binding site [chemical binding]; other site 226900001074 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 226900001075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 226900001076 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 226900001077 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 226900001078 Protein of unknown function DUF45; Region: DUF45; pfam01863 226900001079 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 226900001080 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 226900001081 active site 226900001082 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 226900001083 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226900001084 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 226900001085 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 226900001086 amidohydrolase; Region: amidohydrolases; TIGR01891 226900001087 metal binding site [ion binding]; metal-binding site 226900001088 putative dimer interface [polypeptide binding]; other site 226900001089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900001090 S-adenosylmethionine binding site [chemical binding]; other site 226900001091 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 226900001092 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 226900001093 catalytic residue [active] 226900001094 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 226900001095 catalytic residues [active] 226900001096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900001097 peroxiredoxin; Region: AhpC; TIGR03137 226900001098 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 226900001099 dimer interface [polypeptide binding]; other site 226900001100 decamer (pentamer of dimers) interface [polypeptide binding]; other site 226900001101 catalytic triad [active] 226900001102 peroxidatic and resolving cysteines [active] 226900001103 5-methylribose kinase; Reviewed; Region: PRK12396 226900001104 Phosphotransferase enzyme family; Region: APH; pfam01636 226900001105 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 226900001106 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 226900001107 intersubunit interface [polypeptide binding]; other site 226900001108 active site 226900001109 Zn2+ binding site [ion binding]; other site 226900001110 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900001111 ABC-ATPase subunit interface; other site 226900001112 dimer interface [polypeptide binding]; other site 226900001113 putative PBP binding regions; other site 226900001114 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900001115 ABC-ATPase subunit interface; other site 226900001116 dimer interface [polypeptide binding]; other site 226900001117 putative PBP binding regions; other site 226900001118 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900001119 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 226900001120 putative ligand binding residues [chemical binding]; other site 226900001121 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 226900001122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900001123 DNA binding domain, excisionase family; Region: excise; TIGR01764 226900001124 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 226900001125 Sm and related proteins; Region: Sm_like; cl00259 226900001126 Sm1 motif; other site 226900001127 RNA binding site [nucleotide binding]; other site 226900001128 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 226900001129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900001130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900001131 dimer interface [polypeptide binding]; other site 226900001132 phosphorylation site [posttranslational modification] 226900001133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001134 ATP binding site [chemical binding]; other site 226900001135 Mg2+ binding site [ion binding]; other site 226900001136 G-X-G motif; other site 226900001137 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 226900001138 hypothetical protein; Provisional; Region: PRK06851 226900001139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900001140 Walker A motif; other site 226900001141 ATP binding site [chemical binding]; other site 226900001142 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 226900001143 G1 box; other site 226900001144 GTP/Mg2+ binding site [chemical binding]; other site 226900001145 G2 box; other site 226900001146 Switch I region; other site 226900001147 G3 box; other site 226900001148 Switch II region; other site 226900001149 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 226900001150 benzoate transport; Region: 2A0115; TIGR00895 226900001151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001152 putative substrate translocation pore; other site 226900001153 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 226900001154 FAD dependent oxidoreductase; Region: DAO; pfam01266 226900001155 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 226900001156 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 226900001157 [2Fe-2S] cluster binding site [ion binding]; other site 226900001158 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 226900001159 putative di-iron ligands [ion binding]; other site 226900001160 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226900001161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001162 dimer interface [polypeptide binding]; other site 226900001163 conserved gate region; other site 226900001164 putative PBP binding loops; other site 226900001165 ABC-ATPase subunit interface; other site 226900001166 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226900001167 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900001168 substrate binding pocket [chemical binding]; other site 226900001169 membrane-bound complex binding site; other site 226900001170 hinge residues; other site 226900001171 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226900001172 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 226900001173 Walker A/P-loop; other site 226900001174 ATP binding site [chemical binding]; other site 226900001175 Q-loop/lid; other site 226900001176 ABC transporter signature motif; other site 226900001177 Walker B; other site 226900001178 D-loop; other site 226900001179 H-loop/switch region; other site 226900001180 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 226900001181 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900001182 dimerization interface [polypeptide binding]; other site 226900001183 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226900001184 dimer interface [polypeptide binding]; other site 226900001185 putative CheW interface [polypeptide binding]; other site 226900001186 Arginine repressor [Transcription]; Region: ArgR; COG1438 226900001187 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 226900001188 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 226900001189 arginine deiminase; Provisional; Region: PRK01388 226900001190 ornithine carbamoyltransferase; Validated; Region: PRK02102 226900001191 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226900001192 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 226900001193 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 226900001194 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 226900001195 putative substrate binding site [chemical binding]; other site 226900001196 nucleotide binding site [chemical binding]; other site 226900001197 nucleotide binding site [chemical binding]; other site 226900001198 homodimer interface [polypeptide binding]; other site 226900001199 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226900001200 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900001201 ligand binding site [chemical binding]; other site 226900001202 flexible hinge region; other site 226900001203 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 226900001204 putative switch regulator; other site 226900001205 non-specific DNA interactions [nucleotide binding]; other site 226900001206 DNA binding site [nucleotide binding] 226900001207 sequence specific DNA binding site [nucleotide binding]; other site 226900001208 putative cAMP binding site [chemical binding]; other site 226900001209 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cl00230 226900001210 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 226900001211 FAD binding domain; Region: FAD_binding_4; pfam01565 226900001212 Berberine and berberine like; Region: BBE; pfam08031 226900001213 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 226900001214 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 226900001215 Ca binding site [ion binding]; other site 226900001216 active site 226900001217 catalytic site [active] 226900001218 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226900001219 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 226900001220 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900001221 active site turn [active] 226900001222 phosphorylation site [posttranslational modification] 226900001223 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 226900001224 putative catalytic site [active] 226900001225 putative metal binding site [ion binding]; other site 226900001226 putative phosphate binding site [ion binding]; other site 226900001227 Predicted membrane protein [Function unknown]; Region: COG1511 226900001228 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 226900001229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001230 DNA topoisomerase III; Provisional; Region: PRK07726 226900001231 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226900001232 active site 226900001233 putative interdomain interaction site [polypeptide binding]; other site 226900001234 putative metal-binding site [ion binding]; other site 226900001235 putative nucleotide binding site [chemical binding]; other site 226900001236 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226900001237 domain I; other site 226900001238 DNA binding groove [nucleotide binding] 226900001239 phosphate binding site [ion binding]; other site 226900001240 domain II; other site 226900001241 domain III; other site 226900001242 nucleotide binding site [chemical binding]; other site 226900001243 catalytic site [active] 226900001244 domain IV; other site 226900001245 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 226900001246 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 226900001247 substrate binding site [chemical binding]; other site 226900001248 multimerization interface [polypeptide binding]; other site 226900001249 ATP binding site [chemical binding]; other site 226900001250 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 226900001251 thiamine phosphate binding site [chemical binding]; other site 226900001252 active site 226900001253 pyrophosphate binding site [ion binding]; other site 226900001254 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 226900001255 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 226900001256 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900001257 dimerization interface [polypeptide binding]; other site 226900001258 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 226900001259 dimer interface [polypeptide binding]; other site 226900001260 putative CheW interface [polypeptide binding]; other site 226900001261 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 226900001262 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 226900001263 acyl-activating enzyme (AAE) consensus motif; other site 226900001264 AMP binding site [chemical binding]; other site 226900001265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 226900001266 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 226900001267 Male sterility protein; Region: NAD_binding_4; pfam07993 226900001268 putative NAD(P) binding site [chemical binding]; other site 226900001269 active site 226900001270 putative substrate binding site [chemical binding]; other site 226900001271 Domain of unknown function DUF77; Region: DUF77; pfam01910 226900001272 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 226900001273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001274 dimer interface [polypeptide binding]; other site 226900001275 conserved gate region; other site 226900001276 putative PBP binding loops; other site 226900001277 ABC-ATPase subunit interface; other site 226900001278 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 226900001279 NMT1/THI5 like; Region: NMT1; pfam09084 226900001280 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226900001281 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 226900001282 Walker A/P-loop; other site 226900001283 ATP binding site [chemical binding]; other site 226900001284 Q-loop/lid; other site 226900001285 ABC transporter signature motif; other site 226900001286 Walker B; other site 226900001287 D-loop; other site 226900001288 H-loop/switch region; other site 226900001289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900001290 H-loop/switch region; other site 226900001291 Glyco_18 domain; Region: Glyco_18; smart00636 226900001292 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 226900001293 active site 226900001294 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226900001295 Interdomain contacts; other site 226900001296 Cytokine receptor motif; other site 226900001297 Cellulose binding domain; Region: CBM_2; pfam00553 226900001298 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 226900001299 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900001300 catalytic residues [active] 226900001301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900001302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900001303 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 226900001304 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900001305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001306 putative substrate translocation pore; other site 226900001307 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900001308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900001309 non-specific DNA binding site [nucleotide binding]; other site 226900001310 salt bridge; other site 226900001311 sequence-specific DNA binding site [nucleotide binding]; other site 226900001312 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 226900001313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001314 putative substrate translocation pore; other site 226900001315 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 226900001316 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 226900001317 YesK-like protein; Region: YesK; pfam14150 226900001318 prolyl-tRNA synthetase; Provisional; Region: PRK08661 226900001319 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 226900001320 dimer interface [polypeptide binding]; other site 226900001321 motif 1; other site 226900001322 active site 226900001323 motif 2; other site 226900001324 motif 3; other site 226900001325 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 226900001326 anticodon binding site; other site 226900001327 zinc-binding site [ion binding]; other site 226900001328 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226900001329 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226900001330 nucleotide binding site [chemical binding]; other site 226900001331 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 226900001332 putative metal binding site [ion binding]; other site 226900001333 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 226900001334 putative metal binding site [ion binding]; other site 226900001335 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 226900001336 putative metal binding site [ion binding]; other site 226900001337 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 226900001338 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 226900001339 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 226900001340 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 226900001341 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 226900001342 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 226900001343 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900001344 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 226900001345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900001346 motif II; other site 226900001347 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226900001348 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 226900001349 Low molecular weight phosphatase family; Region: LMWPc; cd00115 226900001350 active site 226900001351 YtxH-like protein; Region: YtxH; pfam12732 226900001352 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 226900001353 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 226900001354 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 226900001355 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900001356 Soluble P-type ATPase [General function prediction only]; Region: COG4087 226900001357 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900001358 EamA-like transporter family; Region: EamA; pfam00892 226900001359 EamA-like transporter family; Region: EamA; pfam00892 226900001360 YhhN-like protein; Region: YhhN; pfam07947 226900001361 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900001362 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900001363 Catalytic site [active] 226900001364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900001365 binding surface 226900001366 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226900001367 TPR motif; other site 226900001368 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 226900001369 Predicted membrane protein [Function unknown]; Region: COG2510 226900001370 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 226900001371 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 226900001372 calcium/proton exchanger (cax); Region: cax; TIGR00378 226900001373 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 226900001374 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 226900001375 YfkD-like protein; Region: YfkD; pfam14167 226900001376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900001377 Radical SAM superfamily; Region: Radical_SAM; pfam04055 226900001378 FeS/SAM binding site; other site 226900001379 YfkB-like domain; Region: YfkB; pfam08756 226900001380 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 226900001381 Fumarase C-terminus; Region: Fumerase_C; pfam05683 226900001382 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 226900001383 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 226900001384 NodB motif; other site 226900001385 active site 226900001386 catalytic site [active] 226900001387 Cd binding site [ion binding]; other site 226900001388 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 226900001389 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226900001390 minor groove reading motif; other site 226900001391 helix-hairpin-helix signature motif; other site 226900001392 substrate binding pocket [chemical binding]; other site 226900001393 active site 226900001394 similar to tRNA (Uracil-5)-methyltransferase; EC_number 2.1.1.35 226900001395 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 226900001396 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 226900001397 dimerization interface 3.5A [polypeptide binding]; other site 226900001398 active site 226900001399 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 226900001400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900001401 Walker A motif; other site 226900001402 ATP binding site [chemical binding]; other site 226900001403 Walker B motif; other site 226900001404 arginine finger; other site 226900001405 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226900001406 hypothetical protein; Validated; Region: PRK06748 226900001407 similar to Arginine permease 226900001408 acetylornithine deacetylase; Validated; Region: PRK08596 226900001409 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 226900001410 metal binding site [ion binding]; metal-binding site 226900001411 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900001412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900001413 non-specific DNA binding site [nucleotide binding]; other site 226900001414 salt bridge; other site 226900001415 sequence-specific DNA binding site [nucleotide binding]; other site 226900001416 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 226900001417 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 226900001418 Domain of unknown function DUF; Region: DUF204; pfam02659 226900001419 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 226900001420 glutaminase A; Region: Gln_ase; TIGR03814 226900001421 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 226900001422 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226900001423 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900001424 active site turn [active] 226900001425 phosphorylation site [posttranslational modification] 226900001426 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900001427 Sm and related proteins; Region: Sm_like; cl00259 226900001428 heptamer interface [polypeptide binding]; other site 226900001429 Sm1 motif; other site 226900001430 hexamer interface [polypeptide binding]; other site 226900001431 RNA binding site [nucleotide binding]; other site 226900001432 Sm2 motif; other site 226900001433 Sm and related proteins; Region: Sm_like; cl00259 226900001434 heptamer interface [polypeptide binding]; other site 226900001435 Sm1 motif; other site 226900001436 hexamer interface [polypeptide binding]; other site 226900001437 RNA binding site [nucleotide binding]; other site 226900001438 Sm2 motif; other site 226900001439 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 226900001440 active site 226900001441 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900001442 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226900001443 active site 226900001444 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 226900001445 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 226900001446 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226900001447 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 226900001448 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900001449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900001450 NAD(P) binding site [chemical binding]; other site 226900001451 active site 226900001452 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900001453 active site 226900001454 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900001455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900001456 active site 226900001457 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 226900001458 Pyruvate formate lyase 1; Region: PFL1; cd01678 226900001459 coenzyme A binding site [chemical binding]; other site 226900001460 active site 226900001461 catalytic residues [active] 226900001462 glycine loop; other site 226900001463 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 226900001464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900001465 FeS/SAM binding site; other site 226900001466 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 226900001467 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 226900001468 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226900001469 YfhE-like protein; Region: YfhE; pfam14152 226900001470 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900001471 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 226900001472 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 226900001473 active site 226900001474 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 226900001475 TIGR01777 family protein; Region: yfcH 226900001476 putative NAD(P) binding site [chemical binding]; other site 226900001477 putative active site [active] 226900001478 recombination regulator RecX; Provisional; Region: recX; PRK14135 226900001479 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 226900001480 YpzG-like protein; Region: YpzG; pfam14139 226900001481 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 226900001482 WVELL protein; Region: WVELL; pfam14043 226900001483 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 226900001484 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 226900001485 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226900001486 minor groove reading motif; other site 226900001487 helix-hairpin-helix signature motif; other site 226900001488 substrate binding pocket [chemical binding]; other site 226900001489 active site 226900001490 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 226900001491 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 226900001492 DNA binding and oxoG recognition site [nucleotide binding] 226900001493 small, acid-soluble spore protein, gamma-type; Region: SASP_gamma; TIGR01442 226900001494 YgaB-like protein; Region: YgaB; pfam14182 226900001495 hypothetical protein; Provisional; Region: PRK13662 226900001496 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900001497 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900001498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900001499 Walker A/P-loop; other site 226900001500 ATP binding site [chemical binding]; other site 226900001501 Q-loop/lid; other site 226900001502 ABC transporter signature motif; other site 226900001503 Walker B; other site 226900001504 D-loop; other site 226900001505 H-loop/switch region; other site 226900001506 Predicted membrane protein [Function unknown]; Region: COG4129 226900001507 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 226900001508 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 226900001509 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 226900001510 active site 226900001511 dimer interface [polypeptide binding]; other site 226900001512 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 226900001513 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 226900001514 active site 226900001515 FMN binding site [chemical binding]; other site 226900001516 substrate binding site [chemical binding]; other site 226900001517 3Fe-4S cluster binding site [ion binding]; other site 226900001518 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 226900001519 domain_subunit interface; other site 226900001520 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 226900001521 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900001522 inhibitor-cofactor binding pocket; inhibition site 226900001523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900001524 catalytic residue [active] 226900001525 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 226900001526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900001527 Walker A/P-loop; other site 226900001528 ATP binding site [chemical binding]; other site 226900001529 Q-loop/lid; other site 226900001530 ABC transporter signature motif; other site 226900001531 Walker B; other site 226900001532 D-loop; other site 226900001533 H-loop/switch region; other site 226900001534 ABC-2 type transporter; Region: ABC2_membrane; cl17235 226900001535 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 226900001536 Ion channel; Region: Ion_trans_2; pfam07885 226900001537 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 226900001538 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 226900001539 catalytic triad [active] 226900001540 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226900001541 metal binding site 2 [ion binding]; metal-binding site 226900001542 putative DNA binding helix; other site 226900001543 metal binding site 1 [ion binding]; metal-binding site 226900001544 dimer interface [polypeptide binding]; other site 226900001545 structural Zn2+ binding site [ion binding]; other site 226900001546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900001547 Coenzyme A binding pocket [chemical binding]; other site 226900001548 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 226900001549 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 226900001550 hypothetical protein; Provisional; Region: PRK12378 226900001551 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900001552 nudix motif; other site 226900001553 Transglycosylase; Region: Transgly; pfam00912 226900001554 Thioredoxin; Region: Thioredoxin_4; pfam13462 226900001555 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 226900001556 epoxyqueuosine reductase; Region: TIGR00276 226900001557 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 226900001558 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 226900001559 HEAT-like repeat; Region: HEAT_EZ; pfam13513 226900001560 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 226900001561 Putative amidase domain; Region: Amidase_6; pfam12671 226900001562 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 226900001563 PAS fold; Region: PAS_4; pfam08448 226900001564 PAS fold; Region: PAS; pfam00989 226900001565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900001566 putative active site [active] 226900001567 heme pocket [chemical binding]; other site 226900001568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900001569 metal binding site [ion binding]; metal-binding site 226900001570 active site 226900001571 I-site; other site 226900001572 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900001573 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 226900001574 PrkA AAA domain; Region: AAA_PrkA; smart00763 226900001575 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 226900001576 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 226900001577 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 226900001578 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001579 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001580 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001581 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001582 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001583 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001584 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001585 Leucine rich repeat; Region: LRR_8; pfam13855 226900001586 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900001587 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226900001588 similar to Acetyltransferase; EC_number 2.3.1.- 226900001589 BCCT family transporter; Region: BCCT; pfam02028 226900001590 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 226900001591 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 226900001592 FOG: PKD repeat [General function prediction only]; Region: COG3291 226900001593 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 226900001594 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900001595 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 226900001596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 226900001597 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 226900001598 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 226900001599 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 226900001600 Cache domain; Region: Cache_1; pfam02743 226900001601 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900001602 dimerization interface [polypeptide binding]; other site 226900001603 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900001604 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 226900001605 dimer interface [polypeptide binding]; other site 226900001606 putative CheW interface [polypeptide binding]; other site 226900001607 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 226900001608 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 226900001609 PAS domain; Region: PAS; smart00091 226900001610 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 226900001611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001612 ATP binding site [chemical binding]; other site 226900001613 Mg2+ binding site [ion binding]; other site 226900001614 G-X-G motif; other site 226900001615 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 226900001616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001617 active site 226900001618 phosphorylation site [posttranslational modification] 226900001619 intermolecular recognition site; other site 226900001620 dimerization interface [polypeptide binding]; other site 226900001621 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 226900001622 Citrate transporter; Region: CitMHS; pfam03600 226900001623 hypothetical protein; Provisional; Region: PRK12784 226900001624 NosL; Region: NosL; cl01769 226900001625 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226900001626 Ankyrin repeat; Region: Ank; pfam00023 226900001627 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226900001628 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226900001629 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 226900001630 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 226900001631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900001632 Walker A/P-loop; other site 226900001633 ATP binding site [chemical binding]; other site 226900001634 Q-loop/lid; other site 226900001635 ABC transporter signature motif; other site 226900001636 Walker B; other site 226900001637 D-loop; other site 226900001638 H-loop/switch region; other site 226900001639 TOBE domain; Region: TOBE_2; pfam08402 226900001640 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 226900001641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001642 dimer interface [polypeptide binding]; other site 226900001643 conserved gate region; other site 226900001644 putative PBP binding loops; other site 226900001645 ABC-ATPase subunit interface; other site 226900001646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900001647 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 226900001648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001649 dimer interface [polypeptide binding]; other site 226900001650 conserved gate region; other site 226900001651 putative PBP binding loops; other site 226900001652 ABC-ATPase subunit interface; other site 226900001653 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 226900001654 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 226900001655 putative protein phosphatase; Region: PHA02239 226900001656 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 226900001657 active site 226900001658 metal binding site [ion binding]; metal-binding site 226900001659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900001660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001661 active site 226900001662 phosphorylation site [posttranslational modification] 226900001663 intermolecular recognition site; other site 226900001664 dimerization interface [polypeptide binding]; other site 226900001665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900001666 DNA binding site [nucleotide binding] 226900001667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900001668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900001669 dimer interface [polypeptide binding]; other site 226900001670 phosphorylation site [posttranslational modification] 226900001671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001672 ATP binding site [chemical binding]; other site 226900001673 Mg2+ binding site [ion binding]; other site 226900001674 G-X-G motif; other site 226900001675 MAEBL; Provisional; Region: PTZ00121 226900001676 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 226900001677 putative active site [active] 226900001678 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 226900001679 Cache domain; Region: Cache_1; pfam02743 226900001680 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900001681 dimerization interface [polypeptide binding]; other site 226900001682 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226900001683 dimer interface [polypeptide binding]; other site 226900001684 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900001685 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 226900001686 dimer interface [polypeptide binding]; other site 226900001687 putative CheW interface [polypeptide binding]; other site 226900001688 sensory histidine kinase DcuS; Provisional; Region: PRK11086 226900001689 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 226900001690 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 226900001691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001692 ATP binding site [chemical binding]; other site 226900001693 Mg2+ binding site [ion binding]; other site 226900001694 G-X-G motif; other site 226900001695 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 226900001696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001697 active site 226900001698 phosphorylation site [posttranslational modification] 226900001699 intermolecular recognition site; other site 226900001700 dimerization interface [polypeptide binding]; other site 226900001701 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 226900001702 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 226900001703 Malic enzyme, N-terminal domain; Region: malic; pfam00390 226900001704 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 226900001705 putative NAD(P) binding site [chemical binding]; other site 226900001706 EamA-like transporter family; Region: EamA; pfam00892 226900001707 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900001708 EamA-like transporter family; Region: EamA; pfam00892 226900001709 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900001710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900001711 DNA-binding site [nucleotide binding]; DNA binding site 226900001712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900001713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900001714 homodimer interface [polypeptide binding]; other site 226900001715 catalytic residue [active] 226900001716 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900001717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900001718 Coenzyme A binding pocket [chemical binding]; other site 226900001719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900001720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900001721 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900001722 dimerization interface [polypeptide binding]; other site 226900001723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900001724 dimer interface [polypeptide binding]; other site 226900001725 phosphorylation site [posttranslational modification] 226900001726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001727 ATP binding site [chemical binding]; other site 226900001728 Mg2+ binding site [ion binding]; other site 226900001729 G-X-G motif; other site 226900001730 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900001731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001732 active site 226900001733 phosphorylation site [posttranslational modification] 226900001734 intermolecular recognition site; other site 226900001735 dimerization interface [polypeptide binding]; other site 226900001736 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900001737 DNA binding site [nucleotide binding] 226900001738 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900001739 Arrestin_N terminal like; Region: LDB19; pfam13002 226900001740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900001741 Coenzyme A binding pocket [chemical binding]; other site 226900001742 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 226900001743 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 226900001744 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900001745 catalytic loop [active] 226900001746 iron binding site [ion binding]; other site 226900001747 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 226900001748 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226900001749 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 226900001750 [4Fe-4S] binding site [ion binding]; other site 226900001751 molybdopterin cofactor binding site; other site 226900001752 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 226900001753 molybdopterin cofactor binding site; other site 226900001754 Uncharacterized conserved protein [Function unknown]; Region: COG2427 226900001755 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 226900001756 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226900001757 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 226900001758 putative active site [active] 226900001759 catalytic site [active] 226900001760 putative metal binding site [ion binding]; other site 226900001761 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 226900001762 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 226900001763 hexamer interface [polypeptide binding]; other site 226900001764 ligand binding site [chemical binding]; other site 226900001765 putative active site [active] 226900001766 NAD(P) binding site [chemical binding]; other site 226900001767 amino acid transporter; Region: 2A0306; TIGR00909 226900001768 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900001769 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900001770 dimerization interface [polypeptide binding]; other site 226900001771 putative DNA binding site [nucleotide binding]; other site 226900001772 putative Zn2+ binding site [ion binding]; other site 226900001773 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226900001774 metal-binding site [ion binding] 226900001775 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 226900001776 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226900001777 metal-binding site [ion binding] 226900001778 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 226900001779 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900001780 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226900001781 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 226900001782 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 226900001783 active site 226900001784 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900001785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900001786 non-specific DNA binding site [nucleotide binding]; other site 226900001787 salt bridge; other site 226900001788 sequence-specific DNA binding site [nucleotide binding]; other site 226900001789 Transposase IS200 like; Region: Y1_Tnp; pfam01797 226900001790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 226900001791 Probable transposase; Region: OrfB_IS605; pfam01385 226900001792 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900001793 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900001794 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900001795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900001796 TPR motif; other site 226900001797 binding surface 226900001798 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900001799 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900001800 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900001801 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 226900001802 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900001803 active site 226900001804 Zn binding site [ion binding]; other site 226900001805 Uncharacterized conserved protein [Function unknown]; Region: COG0398 226900001806 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 226900001807 Transcriptional regulator PadR-like family; Region: PadR; cl17335 226900001808 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 226900001809 VanW like protein; Region: VanW; pfam04294 226900001810 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226900001811 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900001812 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900001813 Nucleoside recognition; Region: Gate; pfam07670 226900001814 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900001815 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 226900001816 putative metal binding site [ion binding]; other site 226900001817 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226900001818 Domain of unknown function DUF21; Region: DUF21; pfam01595 226900001819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226900001820 Transporter associated domain; Region: CorC_HlyC; smart01091 226900001821 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 226900001822 Aspartase; Region: Aspartase; cd01357 226900001823 active sites [active] 226900001824 tetramer interface [polypeptide binding]; other site 226900001825 L-lactate permease; Region: Lactate_perm; cl00701 226900001826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900001827 dimerization interface [polypeptide binding]; other site 226900001828 putative DNA binding site [nucleotide binding]; other site 226900001829 putative Zn2+ binding site [ion binding]; other site 226900001830 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 226900001831 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 226900001832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001833 putative substrate translocation pore; other site 226900001834 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900001835 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 226900001836 siderophore binding site; other site 226900001837 similar to Iron(III) dicitrate transport system permease fecC 226900001838 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900001839 ABC-ATPase subunit interface; other site 226900001840 dimer interface [polypeptide binding]; other site 226900001841 putative PBP binding regions; other site 226900001842 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900001843 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900001844 Walker A/P-loop; other site 226900001845 ATP binding site [chemical binding]; other site 226900001846 Q-loop/lid; other site 226900001847 ABC transporter signature motif; other site 226900001848 Walker B; other site 226900001849 D-loop; other site 226900001850 H-loop/switch region; other site 226900001851 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900001852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900001853 S-adenosylmethionine binding site [chemical binding]; other site 226900001854 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 226900001855 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 226900001856 substrate-cofactor binding pocket; other site 226900001857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900001858 catalytic residue [active] 226900001859 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900001860 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 226900001861 NAD binding site [chemical binding]; other site 226900001862 homodimer interface [polypeptide binding]; other site 226900001863 active site 226900001864 putative substrate binding site [chemical binding]; other site 226900001865 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900001866 nudix motif; other site 226900001867 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 226900001868 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 226900001869 metal ion-dependent adhesion site (MIDAS); other site 226900001870 MoxR-like ATPases [General function prediction only]; Region: COG0714 226900001871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900001872 Walker A motif; other site 226900001873 ATP binding site [chemical binding]; other site 226900001874 Walker B motif; other site 226900001875 arginine finger; other site 226900001876 cardiolipin synthetase; Reviewed; Region: PRK12452 226900001877 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 226900001878 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900001879 putative active site [active] 226900001880 catalytic site [active] 226900001881 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900001882 putative active site [active] 226900001883 catalytic site [active] 226900001884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900001885 PAS domain; Region: PAS_9; pfam13426 226900001886 putative active site [active] 226900001887 heme pocket [chemical binding]; other site 226900001888 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900001889 metal binding site [ion binding]; metal-binding site 226900001890 active site 226900001891 I-site; other site 226900001892 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900001893 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 226900001894 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900001895 Spore germination protein; Region: Spore_permease; cl17796 226900001896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900001897 DNA-binding site [nucleotide binding]; DNA binding site 226900001898 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 226900001899 UTRA domain; Region: UTRA; pfam07702 226900001900 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 226900001901 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900001902 active site turn [active] 226900001903 phosphorylation site [posttranslational modification] 226900001904 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226900001905 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 226900001906 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 226900001907 Ca binding site [ion binding]; other site 226900001908 active site 226900001909 catalytic site [active] 226900001910 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 226900001911 Spore germination protein; Region: Spore_permease; cl17796 226900001912 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900001913 CAAX protease self-immunity; Region: Abi; pfam02517 226900001914 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 226900001915 Phosphotransferase enzyme family; Region: APH; pfam01636 226900001916 active site 226900001917 ATP binding site [chemical binding]; other site 226900001918 substrate binding site [chemical binding]; other site 226900001919 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 226900001920 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900001921 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226900001922 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 226900001923 Walker A/P-loop; other site 226900001924 ATP binding site [chemical binding]; other site 226900001925 Q-loop/lid; other site 226900001926 ABC transporter signature motif; other site 226900001927 Walker B; other site 226900001928 D-loop; other site 226900001929 H-loop/switch region; other site 226900001930 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 226900001931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900001932 substrate binding pocket [chemical binding]; other site 226900001933 membrane-bound complex binding site; other site 226900001934 hinge residues; other site 226900001935 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226900001936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001937 dimer interface [polypeptide binding]; other site 226900001938 conserved gate region; other site 226900001939 putative PBP binding loops; other site 226900001940 ABC-ATPase subunit interface; other site 226900001941 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226900001942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900001943 dimer interface [polypeptide binding]; other site 226900001944 conserved gate region; other site 226900001945 putative PBP binding loops; other site 226900001946 ABC-ATPase subunit interface; other site 226900001947 S-methylmethionine transporter; Provisional; Region: PRK11387 226900001948 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900001949 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 226900001950 similar to Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical); EC_number 3.6.1.17 226900001951 RNA polymerase sigma factor; Provisional; Region: PRK12542 226900001952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900001953 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900001954 DNA binding residues [nucleotide binding] 226900001955 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 226900001956 Predicted transcriptional regulator [Transcription]; Region: COG2378 226900001957 HTH domain; Region: HTH_11; pfam08279 226900001958 WYL domain; Region: WYL; pfam13280 226900001959 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 226900001960 folate binding site [chemical binding]; other site 226900001961 NADP+ binding site [chemical binding]; other site 226900001962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 226900001963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900001964 dimerization interface [polypeptide binding]; other site 226900001965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900001966 dimer interface [polypeptide binding]; other site 226900001967 phosphorylation site [posttranslational modification] 226900001968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900001969 ATP binding site [chemical binding]; other site 226900001970 Mg2+ binding site [ion binding]; other site 226900001971 G-X-G motif; other site 226900001972 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900001973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900001974 active site 226900001975 phosphorylation site [posttranslational modification] 226900001976 intermolecular recognition site; other site 226900001977 dimerization interface [polypeptide binding]; other site 226900001978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900001979 DNA binding site [nucleotide binding] 226900001980 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 226900001981 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 226900001982 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 226900001983 Sulfate transporter family; Region: Sulfate_transp; pfam00916 226900001984 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 226900001985 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226900001986 Ligand Binding Site [chemical binding]; other site 226900001987 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 226900001988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001989 putative substrate translocation pore; other site 226900001990 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900001991 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900001992 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900001993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900001994 putative substrate translocation pore; other site 226900001995 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900001996 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900001997 DNA binding site [nucleotide binding] 226900001998 domain linker motif; other site 226900001999 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 226900002000 dimerization interface [polypeptide binding]; other site 226900002001 ligand binding site [chemical binding]; other site 226900002002 sodium binding site [ion binding]; other site 226900002003 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 226900002004 substrate binding site [chemical binding]; other site 226900002005 dimer interface [polypeptide binding]; other site 226900002006 ATP binding site [chemical binding]; other site 226900002007 D-ribose pyranase; Provisional; Region: PRK11797 226900002008 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 226900002009 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 226900002010 Walker A/P-loop; other site 226900002011 ATP binding site [chemical binding]; other site 226900002012 Q-loop/lid; other site 226900002013 ABC transporter signature motif; other site 226900002014 Walker B; other site 226900002015 D-loop; other site 226900002016 H-loop/switch region; other site 226900002017 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 226900002018 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 226900002019 TM-ABC transporter signature motif; other site 226900002020 similar to D-ribose-binding protein 226900002021 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 226900002022 active site 226900002023 intersubunit interactions; other site 226900002024 catalytic residue [active] 226900002025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 226900002026 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 226900002027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900002029 putative substrate translocation pore; other site 226900002030 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 226900002031 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 226900002032 putative NAD(P) binding site [chemical binding]; other site 226900002033 catalytic Zn binding site [ion binding]; other site 226900002034 Ion channel; Region: Ion_trans_2; pfam07885 226900002035 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 226900002036 Zn binding site [ion binding]; other site 226900002037 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 226900002038 putative catalytic site [active] 226900002039 metal binding site A [ion binding]; metal-binding site 226900002040 phosphate binding site [ion binding]; other site 226900002041 metal binding site C [ion binding]; metal-binding site 226900002042 metal binding site B [ion binding]; metal-binding site 226900002043 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 226900002044 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 226900002045 dimer interface [polypeptide binding]; other site 226900002046 active site 226900002047 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900002048 substrate binding site [chemical binding]; other site 226900002049 catalytic residue [active] 226900002050 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 226900002051 FAD binding domain; Region: FAD_binding_4; pfam01565 226900002052 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 226900002053 VanZ like family; Region: VanZ; pfam04892 226900002054 RDD family; Region: RDD; pfam06271 226900002055 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 226900002056 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 226900002057 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 226900002058 homodimer interface [polypeptide binding]; other site 226900002059 putative GKAP docking site [polypeptide binding]; other site 226900002060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900002061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226900002062 dimer interface [polypeptide binding]; other site 226900002063 putative CheW interface [polypeptide binding]; other site 226900002064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 226900002065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 226900002066 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900002067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900002068 non-specific DNA binding site [nucleotide binding]; other site 226900002069 salt bridge; other site 226900002070 sequence-specific DNA binding site [nucleotide binding]; other site 226900002071 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 226900002072 active site 226900002073 catalytic site [active] 226900002074 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226900002075 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 226900002076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002077 putative substrate translocation pore; other site 226900002078 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 226900002079 Flagellar FliJ protein; Region: FliJ; pfam02050 226900002080 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 226900002081 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 226900002082 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900002083 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 226900002084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900002085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900002086 non-specific DNA binding site [nucleotide binding]; other site 226900002087 salt bridge; other site 226900002088 sequence-specific DNA binding site [nucleotide binding]; other site 226900002089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900002090 Coenzyme A binding pocket [chemical binding]; other site 226900002091 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 226900002092 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 226900002093 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 226900002094 TrkA-N domain; Region: TrkA_N; pfam02254 226900002095 TrkA-C domain; Region: TrkA_C; pfam02080 226900002096 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 226900002097 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 226900002098 Subunit I/III interface [polypeptide binding]; other site 226900002099 Subunit III/IV interface [polypeptide binding]; other site 226900002100 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 226900002101 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 226900002102 D-pathway; other site 226900002103 Putative ubiquinol binding site [chemical binding]; other site 226900002104 Low-spin heme (heme b) binding site [chemical binding]; other site 226900002105 Putative water exit pathway; other site 226900002106 Binuclear center (heme o3/CuB) [ion binding]; other site 226900002107 K-pathway; other site 226900002108 Putative proton exit pathway; other site 226900002109 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 226900002110 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 226900002111 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 226900002112 S-methylmethionine transporter; Provisional; Region: PRK11387 226900002113 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900002114 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 226900002115 putative active site [active] 226900002116 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900002117 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 226900002118 metal binding site [ion binding]; metal-binding site 226900002119 dimer interface [polypeptide binding]; other site 226900002120 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 226900002121 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 226900002122 Na binding site [ion binding]; other site 226900002123 similar to Spore germination protein KA 226900002124 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 226900002125 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 226900002126 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 226900002127 Nucleoside recognition; Region: Gate; pfam07670 226900002128 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 226900002129 Nucleoside recognition; Region: Gate; pfam07670 226900002130 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 226900002131 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 226900002132 G1 box; other site 226900002133 GTP/Mg2+ binding site [chemical binding]; other site 226900002134 Switch I region; other site 226900002135 G2 box; other site 226900002136 G3 box; other site 226900002137 Switch II region; other site 226900002138 G4 box; other site 226900002139 G5 box; other site 226900002140 FeoA domain; Region: FeoA; pfam04023 226900002141 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 226900002142 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 226900002143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002144 dimer interface [polypeptide binding]; other site 226900002145 conserved gate region; other site 226900002146 putative PBP binding loops; other site 226900002147 ABC-ATPase subunit interface; other site 226900002148 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 226900002149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002150 dimer interface [polypeptide binding]; other site 226900002151 conserved gate region; other site 226900002152 putative PBP binding loops; other site 226900002153 ABC-ATPase subunit interface; other site 226900002154 AAA domain; Region: AAA_17; cl19128 226900002155 AAA domain; Region: AAA_33; pfam13671 226900002156 Transport protein particle (TRAPP) component; Region: TRAPP; cl02135 226900002157 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226900002158 MMPL family; Region: MMPL; cl14618 226900002159 MMPL family; Region: MMPL; cl14618 226900002160 FOG: CBS domain [General function prediction only]; Region: COG0517 226900002161 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 226900002162 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 226900002163 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 226900002164 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900002165 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900002166 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900002167 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226900002168 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900002169 Putative transcription activator [Transcription]; Region: TenA; COG0819 226900002170 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226900002171 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 226900002172 Walker A/P-loop; other site 226900002173 ATP binding site [chemical binding]; other site 226900002174 Q-loop/lid; other site 226900002175 ABC transporter signature motif; other site 226900002176 Walker B; other site 226900002177 D-loop; other site 226900002178 H-loop/switch region; other site 226900002179 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 226900002180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002181 dimer interface [polypeptide binding]; other site 226900002182 conserved gate region; other site 226900002183 putative PBP binding loops; other site 226900002184 ABC-ATPase subunit interface; other site 226900002185 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 226900002186 NMT1/THI5 like; Region: NMT1; pfam09084 226900002187 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 226900002188 thiamine phosphate binding site [chemical binding]; other site 226900002189 active site 226900002190 pyrophosphate binding site [ion binding]; other site 226900002191 Squalene epoxidase; Region: SE; cl17314 226900002192 FAD dependent oxidoreductase; Region: DAO; pfam01266 226900002193 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 226900002194 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 226900002195 thiS-thiF/thiG interaction site; other site 226900002196 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 226900002197 ThiS interaction site; other site 226900002198 putative active site [active] 226900002199 tetramer interface [polypeptide binding]; other site 226900002200 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 226900002201 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 226900002202 ATP binding site [chemical binding]; other site 226900002203 substrate interface [chemical binding]; other site 226900002204 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 226900002205 dimer interface [polypeptide binding]; other site 226900002206 substrate binding site [chemical binding]; other site 226900002207 ATP binding site [chemical binding]; other site 226900002208 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 226900002209 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 226900002210 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900002211 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226900002212 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 226900002213 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 226900002214 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 226900002215 Ligand Binding Site [chemical binding]; other site 226900002216 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 226900002217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002218 putative substrate translocation pore; other site 226900002219 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 226900002220 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900002221 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 226900002222 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 226900002223 active site 226900002224 nucleophile elbow; other site 226900002225 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900002226 FtsX-like permease family; Region: FtsX; pfam02687 226900002227 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900002228 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900002229 Walker A/P-loop; other site 226900002230 ATP binding site [chemical binding]; other site 226900002231 Q-loop/lid; other site 226900002232 ABC transporter signature motif; other site 226900002233 Walker B; other site 226900002234 D-loop; other site 226900002235 H-loop/switch region; other site 226900002236 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 226900002237 TM-ABC transporter signature motif; other site 226900002238 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 226900002239 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 226900002240 Walker A/P-loop; other site 226900002241 ATP binding site [chemical binding]; other site 226900002242 Q-loop/lid; other site 226900002243 ABC transporter signature motif; other site 226900002244 Walker B; other site 226900002245 D-loop; other site 226900002246 H-loop/switch region; other site 226900002247 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 226900002248 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 226900002249 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 226900002250 putative ligand binding site [chemical binding]; other site 226900002251 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 226900002252 oxidoreductase; Provisional; Region: PRK06128 226900002253 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 226900002254 NAD binding site [chemical binding]; other site 226900002255 metal binding site [ion binding]; metal-binding site 226900002256 active site 226900002257 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 226900002258 putative substrate binding site [chemical binding]; other site 226900002259 putative ATP binding site [chemical binding]; other site 226900002260 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 226900002261 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 226900002262 substrate binding [chemical binding]; other site 226900002263 active site 226900002264 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 226900002265 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 226900002266 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900002267 active site turn [active] 226900002268 phosphorylation site [posttranslational modification] 226900002269 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226900002270 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900002271 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900002272 DNA binding site [nucleotide binding] 226900002273 domain linker motif; other site 226900002274 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 226900002275 dimerization interface [polypeptide binding]; other site 226900002276 ligand binding site [chemical binding]; other site 226900002277 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 226900002278 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900002279 catalytic residues [active] 226900002280 putative disulfide oxidoreductase; Provisional; Region: PRK03113 226900002281 YhdB-like protein; Region: YhdB; pfam14148 226900002282 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 226900002283 Spore germination protein; Region: Spore_permease; cl17796 226900002284 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 226900002285 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900002286 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 226900002287 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 226900002288 putative FMN binding site [chemical binding]; other site 226900002289 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 226900002290 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 226900002291 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 226900002292 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 226900002293 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 226900002294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900002295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900002296 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226900002297 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 226900002298 active site residue [active] 226900002299 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 226900002300 putative homodimer interface [polypeptide binding]; other site 226900002301 putative homotetramer interface [polypeptide binding]; other site 226900002302 putative metal binding site [ion binding]; other site 226900002303 putative homodimer-homodimer interface [polypeptide binding]; other site 226900002304 putative allosteric switch controlling residues; other site 226900002305 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 226900002306 CPxP motif; other site 226900002307 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900002308 active site residue [active] 226900002309 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 226900002310 active site residue [active] 226900002311 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900002312 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 226900002313 CPxP motif; other site 226900002314 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900002315 active site residue [active] 226900002316 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900002317 active site residue [active] 226900002318 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 226900002319 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900002320 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226900002321 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 226900002322 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 226900002323 NADP binding site [chemical binding]; other site 226900002324 dimer interface [polypeptide binding]; other site 226900002325 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 226900002326 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 226900002327 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 226900002328 PhoU domain; Region: PhoU; pfam01895 226900002329 PhoU domain; Region: PhoU; pfam01895 226900002330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900002332 putative substrate translocation pore; other site 226900002333 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 226900002334 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 226900002335 HTH domain; Region: HTH_11; pfam08279 226900002336 Mga helix-turn-helix domain; Region: Mga; pfam05043 226900002337 PRD domain; Region: PRD; pfam00874 226900002338 PRD domain; Region: PRD; pfam00874 226900002339 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 226900002340 active site 226900002341 P-loop; other site 226900002342 phosphorylation site [posttranslational modification] 226900002343 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226900002344 active site 226900002345 phosphorylation site [posttranslational modification] 226900002346 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 226900002347 active site 226900002348 methionine cluster; other site 226900002349 phosphorylation site [posttranslational modification] 226900002350 metal binding site [ion binding]; metal-binding site 226900002351 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226900002352 active site 226900002353 P-loop; other site 226900002354 phosphorylation site [posttranslational modification] 226900002355 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226900002356 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 226900002357 HEAT repeats; Region: HEAT_2; pfam13646 226900002358 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900002359 Bacterial SH3 domain homologues; Region: SH3b; smart00287 226900002360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 226900002361 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226900002362 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900002363 FtsX-like permease family; Region: FtsX; pfam02687 226900002364 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900002365 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900002366 Walker A/P-loop; other site 226900002367 ATP binding site [chemical binding]; other site 226900002368 Q-loop/lid; other site 226900002369 ABC transporter signature motif; other site 226900002370 Walker B; other site 226900002371 D-loop; other site 226900002372 H-loop/switch region; other site 226900002373 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226900002374 HlyD family secretion protein; Region: HlyD_3; pfam13437 226900002375 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 226900002376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002377 dimer interface [polypeptide binding]; other site 226900002378 conserved gate region; other site 226900002379 putative PBP binding loops; other site 226900002380 ABC-ATPase subunit interface; other site 226900002381 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900002382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002383 dimer interface [polypeptide binding]; other site 226900002384 conserved gate region; other site 226900002385 ABC-ATPase subunit interface; other site 226900002386 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 226900002387 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 226900002388 dimanganese center [ion binding]; other site 226900002389 CotJB protein; Region: CotJB; pfam12652 226900002390 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 226900002391 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900002392 active site 226900002393 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 226900002394 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 226900002395 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 226900002396 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 226900002397 putative DNA binding site [nucleotide binding]; other site 226900002398 putative homodimer interface [polypeptide binding]; other site 226900002399 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 226900002400 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 226900002401 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 226900002402 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 226900002403 similar to phosphohydrolases, Icc family 226900002404 similar to Amino acid permease 226900002405 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 226900002406 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226900002407 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226900002408 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226900002409 putative active site [active] 226900002410 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 226900002411 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 226900002412 putative active site [active] 226900002413 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 226900002414 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900002415 active site turn [active] 226900002416 phosphorylation site [posttranslational modification] 226900002417 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226900002418 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 226900002419 DoxX; Region: DoxX; pfam07681 226900002420 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 226900002421 hypothetical protein; Provisional; Region: PRK06770 226900002422 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900002423 EamA-like transporter family; Region: EamA; pfam00892 226900002424 EamA-like transporter family; Region: EamA; pfam00892 226900002425 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900002426 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 226900002427 putative DNA binding site [nucleotide binding]; other site 226900002428 putative Zn2+ binding site [ion binding]; other site 226900002429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900002430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900002431 Coenzyme A binding pocket [chemical binding]; other site 226900002432 classical (c) SDRs; Region: SDR_c; cd05233 226900002433 short chain dehydrogenase; Region: adh_short; pfam00106 226900002434 NAD(P) binding site [chemical binding]; other site 226900002435 active site 226900002436 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900002437 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 226900002438 DNA binding residues [nucleotide binding] 226900002439 putative dimer interface [polypeptide binding]; other site 226900002440 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 226900002441 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 226900002442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900002443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900002444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900002446 putative substrate translocation pore; other site 226900002447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900002448 dimerization interface [polypeptide binding]; other site 226900002449 putative DNA binding site [nucleotide binding]; other site 226900002450 putative Zn2+ binding site [ion binding]; other site 226900002451 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 226900002452 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 226900002453 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 226900002454 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 226900002455 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 226900002456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900002457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002458 putative substrate translocation pore; other site 226900002459 intracellular protease, PfpI family; Region: PfpI; TIGR01382 226900002460 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 226900002461 proposed catalytic triad [active] 226900002462 conserved cys residue [active] 226900002463 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 226900002464 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 226900002465 tetramer interface [polypeptide binding]; other site 226900002466 heme binding pocket [chemical binding]; other site 226900002467 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 226900002468 conserved cys residue [active] 226900002469 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 226900002470 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 226900002471 Spore germination protein; Region: Spore_permease; cl17796 226900002472 glutamate racemase; Provisional; Region: PRK00865 226900002473 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 226900002474 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 226900002475 tetrameric interface [polypeptide binding]; other site 226900002476 activator binding site; other site 226900002477 NADP binding site [chemical binding]; other site 226900002478 substrate binding site [chemical binding]; other site 226900002479 catalytic residues [active] 226900002480 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900002481 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 226900002482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900002483 Walker A/P-loop; other site 226900002484 ATP binding site [chemical binding]; other site 226900002485 Q-loop/lid; other site 226900002486 ABC transporter signature motif; other site 226900002487 Walker B; other site 226900002488 D-loop; other site 226900002489 H-loop/switch region; other site 226900002490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900002491 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900002492 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 226900002493 Walker A/P-loop; other site 226900002494 ATP binding site [chemical binding]; other site 226900002495 Q-loop/lid; other site 226900002496 ABC transporter signature motif; other site 226900002497 Walker B; other site 226900002498 D-loop; other site 226900002499 H-loop/switch region; other site 226900002500 cystine transporter subunit; Provisional; Region: PRK11260 226900002501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900002502 substrate binding pocket [chemical binding]; other site 226900002503 membrane-bound complex binding site; other site 226900002504 hinge residues; other site 226900002505 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226900002506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002507 dimer interface [polypeptide binding]; other site 226900002508 conserved gate region; other site 226900002509 putative PBP binding loops; other site 226900002510 ABC-ATPase subunit interface; other site 226900002511 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226900002512 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 226900002513 Walker A/P-loop; other site 226900002514 ATP binding site [chemical binding]; other site 226900002515 Q-loop/lid; other site 226900002516 ABC transporter signature motif; other site 226900002517 Walker B; other site 226900002518 D-loop; other site 226900002519 H-loop/switch region; other site 226900002520 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900002521 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 226900002522 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 226900002523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 226900002524 Protein of unknown function (DUF445); Region: DUF445; pfam04286 226900002525 hypothetical protein; Provisional; Region: PRK13676 226900002526 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 226900002527 protein binding site [polypeptide binding]; other site 226900002528 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900002529 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 226900002530 Histidine kinase; Region: HisKA_3; pfam07730 226900002531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900002532 ATP binding site [chemical binding]; other site 226900002533 Mg2+ binding site [ion binding]; other site 226900002534 G-X-G motif; other site 226900002535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900002536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900002537 active site 226900002538 phosphorylation site [posttranslational modification] 226900002539 intermolecular recognition site; other site 226900002540 dimerization interface [polypeptide binding]; other site 226900002541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900002542 DNA binding residues [nucleotide binding] 226900002543 dimerization interface [polypeptide binding]; other site 226900002544 acetolactate synthase; Reviewed; Region: PRK08617 226900002545 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 226900002546 PYR/PP interface [polypeptide binding]; other site 226900002547 dimer interface [polypeptide binding]; other site 226900002548 TPP binding site [chemical binding]; other site 226900002549 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 226900002550 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 226900002551 TPP-binding site [chemical binding]; other site 226900002552 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 226900002553 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 226900002554 active site 226900002555 DNA binding site [nucleotide binding] 226900002556 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 226900002557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900002558 active site 226900002559 motif I; other site 226900002560 motif II; other site 226900002561 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900002562 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 226900002563 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002564 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002565 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900002566 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002567 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002568 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002569 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002570 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002571 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002572 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002573 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900002574 amidase catalytic site [active] 226900002575 Zn binding residues [ion binding]; other site 226900002576 substrate binding site [chemical binding]; other site 226900002577 S-layer homology domain; Region: SLH; pfam00395 226900002578 S-layer homology domain; Region: SLH; pfam00395 226900002579 S-layer homology domain; Region: SLH; pfam00395 226900002580 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 226900002581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900002582 FeS/SAM binding site; other site 226900002583 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 226900002584 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 226900002585 acyl-activating enzyme (AAE) consensus motif; other site 226900002586 putative AMP binding site [chemical binding]; other site 226900002587 putative active site [active] 226900002588 putative CoA binding site [chemical binding]; other site 226900002589 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 226900002590 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 226900002591 Sulfate transporter family; Region: Sulfate_transp; cl19250 226900002592 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 226900002593 stage V sporulation protein B; Region: spore_V_B; TIGR02900 226900002594 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 226900002595 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 226900002596 S-layer homology domain; Region: SLH; pfam00395 226900002597 S-layer homology domain; Region: SLH; pfam00395 226900002598 S-layer homology domain; Region: SLH; pfam00395 226900002599 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 226900002600 O-Antigen ligase; Region: Wzy_C; cl04850 226900002601 enoyl-CoA hydratase; Provisional; Region: PRK07659 226900002602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900002603 substrate binding site [chemical binding]; other site 226900002604 oxyanion hole (OAH) forming residues; other site 226900002605 trimer interface [polypeptide binding]; other site 226900002606 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 226900002607 metal binding site [ion binding]; metal-binding site 226900002608 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 226900002609 putative oligomer interface [polypeptide binding]; other site 226900002610 putative active site [active] 226900002611 metal binding site [ion binding]; metal-binding site 226900002612 S-layer homology domain; Region: SLH; pfam00395 226900002613 S-layer homology domain; Region: SLH; pfam00395 226900002614 S-layer homology domain; Region: SLH; pfam00395 226900002615 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 226900002616 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900002617 active site 226900002618 metal binding site [ion binding]; metal-binding site 226900002619 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 226900002620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900002621 S-adenosylmethionine binding site [chemical binding]; other site 226900002622 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 226900002623 proline racemase; Provisional; Region: PRK13969 226900002624 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 226900002625 ornithine cyclodeaminase; Validated; Region: PRK08618 226900002626 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 226900002627 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 226900002628 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 226900002629 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900002630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002631 dimer interface [polypeptide binding]; other site 226900002632 conserved gate region; other site 226900002633 putative PBP binding loops; other site 226900002634 ABC-ATPase subunit interface; other site 226900002635 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900002636 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 226900002637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900002638 dimer interface [polypeptide binding]; other site 226900002639 conserved gate region; other site 226900002640 putative PBP binding loops; other site 226900002641 ABC-ATPase subunit interface; other site 226900002642 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226900002643 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226900002644 Walker A/P-loop; other site 226900002645 ATP binding site [chemical binding]; other site 226900002646 Q-loop/lid; other site 226900002647 ABC transporter signature motif; other site 226900002648 Walker B; other site 226900002649 D-loop; other site 226900002650 H-loop/switch region; other site 226900002651 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900002652 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 226900002653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226900002654 Walker A/P-loop; other site 226900002655 ATP binding site [chemical binding]; other site 226900002656 Q-loop/lid; other site 226900002657 ABC transporter signature motif; other site 226900002658 Walker B; other site 226900002659 D-loop; other site 226900002660 H-loop/switch region; other site 226900002661 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900002662 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 226900002663 catalytic residues [active] 226900002664 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 226900002665 SnoaL-like domain; Region: SnoaL_2; pfam12680 226900002666 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 226900002667 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 226900002668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 226900002669 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 226900002670 LXG domain of WXG superfamily; Region: LXG; pfam04740 226900002671 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 226900002672 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 226900002673 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 226900002674 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 226900002675 HNH/Endo VII superfamily nuclease toxins; Region: Tox-HNH-EHHH; pfam15657 226900002676 Immunity protein 30; Region: Imm30; pfam15594 226900002677 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 226900002678 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 226900002679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002680 putative substrate translocation pore; other site 226900002681 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 226900002682 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 226900002683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900002684 putative active site [active] 226900002685 heme pocket [chemical binding]; other site 226900002686 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 226900002687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900002688 ATP binding site [chemical binding]; other site 226900002689 Mg2+ binding site [ion binding]; other site 226900002690 G-X-G motif; other site 226900002691 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 226900002692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900002693 active site 226900002694 phosphorylation site [posttranslational modification] 226900002695 intermolecular recognition site; other site 226900002696 dimerization interface [polypeptide binding]; other site 226900002697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 226900002698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226900002699 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 226900002700 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 226900002701 cofactor binding site; other site 226900002702 DNA binding site [nucleotide binding] 226900002703 substrate interaction site [chemical binding]; other site 226900002704 Helix-turn-helix domain; Region: HTH_36; pfam13730 226900002705 Protein of unknown function DUF262; Region: DUF262; pfam03235 226900002706 Uncharacterized conserved protein [Function unknown]; Region: COG3472 226900002707 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226900002708 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226900002709 Int/Topo IB signature motif; other site 226900002710 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 226900002711 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 226900002712 Glycosyl transferase family 64 domain; Region: Glyco_transf_64; pfam09258 226900002713 RelB antitoxin; Region: RelB; cl01171 226900002714 Tic20-like protein; Region: Tic20; pfam09685 226900002715 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900002716 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 226900002717 DNA binding residues [nucleotide binding] 226900002718 dimer interface [polypeptide binding]; other site 226900002719 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 226900002720 replicative DNA helicase; Provisional; Region: PRK06749 226900002721 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 226900002722 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 226900002723 Walker A motif; other site 226900002724 ATP binding site [chemical binding]; other site 226900002725 Walker B motif; other site 226900002726 DNA binding loops [nucleotide binding] 226900002727 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 226900002728 Predicted transcriptional regulators [Transcription]; Region: COG1378 226900002729 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 226900002730 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 226900002731 C-terminal domain interface [polypeptide binding]; other site 226900002732 sugar binding site [chemical binding]; other site 226900002733 hypothetical protein; Provisional; Region: PRK10621 226900002734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900002735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900002736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900002737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900002738 putative substrate translocation pore; other site 226900002739 hypothetical protein; Provisional; Region: PRK06770 226900002740 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900002741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900002742 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 226900002743 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226900002744 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 226900002745 active site 226900002746 catalytic site [active] 226900002747 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 226900002748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900002749 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226900002750 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226900002751 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 226900002752 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 226900002753 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 226900002754 CGNR zinc finger; Region: zf-CGNR; pfam11706 226900002755 HPP family; Region: HPP; pfam04982 226900002756 YmzC-like protein; Region: YmzC; pfam14157 226900002757 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900002758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 226900002759 putative Zn2+ binding site [ion binding]; other site 226900002760 putative DNA binding site [nucleotide binding]; other site 226900002761 dimerization interface [polypeptide binding]; other site 226900002762 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 226900002763 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 226900002764 ATP synthase I chain; Region: ATP_synt_I; pfam03899 226900002765 VanZ like family; Region: VanZ; pfam04892 226900002766 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 226900002767 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 226900002768 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 226900002769 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 226900002770 dihydroxyacetone kinase; Provisional; Region: PRK14479 226900002771 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 226900002772 DAK2 domain; Region: Dak2; pfam02734 226900002773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900002774 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900002775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900002776 TPR motif; other site 226900002777 binding surface 226900002778 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900002779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900002780 non-specific DNA binding site [nucleotide binding]; other site 226900002781 salt bridge; other site 226900002782 sequence-specific DNA binding site [nucleotide binding]; other site 226900002783 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900002784 S-layer homology domain; Region: SLH; pfam00395 226900002785 S-layer homology domain; Region: SLH; pfam00395 226900002786 S-layer homology domain; Region: SLH; pfam00395 226900002787 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 226900002788 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900002789 Predicted transcriptional regulators [Transcription]; Region: COG1695 226900002790 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 226900002791 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 226900002792 Heat induced stress protein YflT; Region: YflT; pfam11181 226900002793 CsbD-like; Region: CsbD; pfam05532 226900002794 Predicted membrane protein [Function unknown]; Region: COG2261 226900002795 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 226900002796 anti sigma factor interaction site; other site 226900002797 regulatory phosphorylation site [posttranslational modification]; other site 226900002798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900002799 ATP binding site [chemical binding]; other site 226900002800 Mg2+ binding site [ion binding]; other site 226900002801 G-X-G motif; other site 226900002802 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 226900002803 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900002804 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226900002805 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900002806 DNA binding residues [nucleotide binding] 226900002807 Ferritin-like domain; Region: Ferritin; pfam00210 226900002808 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 226900002809 dinuclear metal binding motif [ion binding]; other site 226900002810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900002811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900002812 active site 226900002813 phosphorylation site [posttranslational modification] 226900002814 intermolecular recognition site; other site 226900002815 dimerization interface [polypeptide binding]; other site 226900002816 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 226900002817 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 226900002818 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 226900002819 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 226900002820 CHASE3 domain; Region: CHASE3; pfam05227 226900002821 HAMP domain; Region: HAMP; pfam00672 226900002822 GAF domain; Region: GAF_2; pfam13185 226900002823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900002824 Borna disease virus P24 protein; Region: BDV_P24; pfam06595 226900002825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900002826 dimer interface [polypeptide binding]; other site 226900002827 phosphorylation site [posttranslational modification] 226900002828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900002829 ATP binding site [chemical binding]; other site 226900002830 Mg2+ binding site [ion binding]; other site 226900002831 G-X-G motif; other site 226900002832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900002833 active site 226900002834 phosphorylation site [posttranslational modification] 226900002835 intermolecular recognition site; other site 226900002836 dimerization interface [polypeptide binding]; other site 226900002837 regulatory protein interface [polypeptide binding]; other site 226900002838 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 226900002839 regulatory phosphorylation site [posttranslational modification]; other site 226900002840 Heat induced stress protein YflT; Region: YflT; pfam11181 226900002841 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 226900002842 hypothetical protein; Provisional; Region: PRK12856 226900002843 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900002844 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 226900002845 NADP binding site [chemical binding]; other site 226900002846 dimer interface [polypeptide binding]; other site 226900002847 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 226900002848 active site 226900002849 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 226900002850 YhzD-like protein; Region: YhzD; pfam14120 226900002851 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 226900002852 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 226900002853 active site 226900002854 metal binding site [ion binding]; metal-binding site 226900002855 DNA binding site [nucleotide binding] 226900002856 AAA domain; Region: AAA_23; pfam13476 226900002857 AAA domain; Region: AAA_27; pfam13514 226900002858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900002859 Q-loop/lid; other site 226900002860 ABC transporter signature motif; other site 226900002861 Walker B; other site 226900002862 D-loop; other site 226900002863 H-loop/switch region; other site 226900002864 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 226900002865 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 226900002866 generic binding surface I; other site 226900002867 generic binding surface II; other site 226900002868 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900002869 Zn2+ binding site [ion binding]; other site 226900002870 Mg2+ binding site [ion binding]; other site 226900002871 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 226900002872 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 226900002873 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226900002874 Zn binding site [ion binding]; other site 226900002875 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226900002876 Zn binding site [ion binding]; other site 226900002877 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226900002878 Zn binding site [ion binding]; other site 226900002879 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226900002880 Zn binding site [ion binding]; other site 226900002881 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900002882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900002883 TPR motif; other site 226900002884 binding surface 226900002885 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900002886 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900002887 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 226900002888 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 226900002889 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 226900002890 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 226900002891 Cupin; Region: Cupin_1; smart00835 226900002892 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 226900002893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900002894 non-specific DNA binding site [nucleotide binding]; other site 226900002895 salt bridge; other site 226900002896 sequence-specific DNA binding site [nucleotide binding]; other site 226900002897 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 226900002898 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 226900002899 amphipathic channel; other site 226900002900 Asn-Pro-Ala signature motifs; other site 226900002901 glycerol kinase; Provisional; Region: glpK; PRK00047 226900002902 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 226900002903 N- and C-terminal domain interface [polypeptide binding]; other site 226900002904 active site 226900002905 MgATP binding site [chemical binding]; other site 226900002906 catalytic site [active] 226900002907 metal binding site [ion binding]; metal-binding site 226900002908 glycerol binding site [chemical binding]; other site 226900002909 homotetramer interface [polypeptide binding]; other site 226900002910 homodimer interface [polypeptide binding]; other site 226900002911 FBP binding site [chemical binding]; other site 226900002912 protein IIAGlc interface [polypeptide binding]; other site 226900002913 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 226900002914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900002915 Transcriptional regulator PadR-like family; Region: PadR; cl17335 226900002916 VanZ like family; Region: VanZ; cl01971 226900002917 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 226900002918 Part of AAA domain; Region: AAA_19; pfam13245 226900002919 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226900002920 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 226900002921 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 226900002922 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 226900002923 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 226900002924 transcriptional regulator Hpr; Provisional; Region: PRK13777 226900002925 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900002926 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 226900002927 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 226900002928 HIT family signature motif; other site 226900002929 catalytic residue [active] 226900002930 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226900002931 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900002932 Walker A/P-loop; other site 226900002933 ATP binding site [chemical binding]; other site 226900002934 Q-loop/lid; other site 226900002935 ABC transporter signature motif; other site 226900002936 Walker B; other site 226900002937 D-loop; other site 226900002938 H-loop/switch region; other site 226900002939 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 226900002940 EcsC protein family; Region: EcsC; pfam12787 226900002941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900002942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900002943 Bacterial PH domain; Region: bPH_2; cl01348 226900002944 Predicted membrane protein [Function unknown]; Region: COG3428 226900002945 Bacterial PH domain; Region: bPH_2; pfam03703 226900002946 Bacterial PH domain; Region: bPH_2; pfam03703 226900002947 Bacterial PH domain; Region: bPH_2; pfam03703 226900002948 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 226900002949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900002950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900002951 Collagen binding domain; Region: Collagen_bind; pfam05737 226900002952 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900002953 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002954 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002955 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002956 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900002957 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002958 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002959 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002960 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002961 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900002962 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002963 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002964 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002965 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002966 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900002967 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002968 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002969 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002970 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002971 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900002972 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002973 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002974 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002975 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002976 Cna protein B-type domain; Region: Cna_B; pfam05738 226900002977 2OG-Fe dioxygenase; Region: 2OG-Fe_Oxy_2; pfam10014 226900002978 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 226900002979 classical (c) SDRs; Region: SDR_c; cd05233 226900002980 NAD(P) binding site [chemical binding]; other site 226900002981 active site 226900002982 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900002983 EamA-like transporter family; Region: EamA; pfam00892 226900002984 EamA-like transporter family; Region: EamA; pfam00892 226900002985 Bacterial PH domain; Region: bPH_2; cl01348 226900002986 Predicted membrane protein [Function unknown]; Region: COG3428 226900002987 Bacterial PH domain; Region: bPH_2; pfam03703 226900002988 Bacterial PH domain; Region: bPH_2; pfam03703 226900002989 Bacterial PH domain; Region: bPH_2; pfam03703 226900002990 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 226900002991 Transglycosylase; Region: Transgly; pfam00912 226900002992 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226900002993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900002994 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 226900002995 substrate binding site [chemical binding]; other site 226900002996 active site 226900002997 ferrochelatase; Provisional; Region: PRK12435 226900002998 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 226900002999 C-terminal domain interface [polypeptide binding]; other site 226900003000 active site 226900003001 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 226900003002 active site 226900003003 N-terminal domain interface [polypeptide binding]; other site 226900003004 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 226900003005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226900003006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900003007 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 226900003008 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl19625 226900003009 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 226900003010 Fn3 associated; Region: Fn3_assoc; pfam13287 226900003011 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 226900003012 generic binding surface II; other site 226900003013 generic binding surface I; other site 226900003014 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 226900003015 putative active site [active] 226900003016 putative catalytic site [active] 226900003017 putative Mg binding site IVb [ion binding]; other site 226900003018 putative phosphate binding site [ion binding]; other site 226900003019 putative DNA binding site [nucleotide binding]; other site 226900003020 putative Mg binding site IVa [ion binding]; other site 226900003021 Penicillinase repressor; Region: Penicillinase_R; pfam03965 226900003022 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 226900003023 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 226900003024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900003025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900003026 Predicted membrane protein [Function unknown]; Region: COG1511 226900003027 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 226900003028 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 226900003029 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 226900003030 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 226900003031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900003032 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 226900003033 Bacterial PH domain; Region: bPH_3; pfam14470 226900003034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900003035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900003036 Coenzyme A binding pocket [chemical binding]; other site 226900003037 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900003038 DNA binding site [nucleotide binding] 226900003039 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 226900003040 domain linker motif; other site 226900003041 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226900003042 putative dimerization interface [polypeptide binding]; other site 226900003043 putative ligand binding site [chemical binding]; other site 226900003044 YhfH-like protein; Region: YhfH; pfam14149 226900003045 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 226900003046 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 226900003047 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 226900003048 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 226900003049 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 226900003050 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 226900003051 acyl-activating enzyme (AAE) consensus motif; other site 226900003052 putative AMP binding site [chemical binding]; other site 226900003053 putative active site [active] 226900003054 putative CoA binding site [chemical binding]; other site 226900003055 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 226900003056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003057 dimer interface [polypeptide binding]; other site 226900003058 conserved gate region; other site 226900003059 putative PBP binding loops; other site 226900003060 ABC-ATPase subunit interface; other site 226900003061 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 226900003062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003063 dimer interface [polypeptide binding]; other site 226900003064 conserved gate region; other site 226900003065 putative PBP binding loops; other site 226900003066 ABC-ATPase subunit interface; other site 226900003067 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 226900003068 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 226900003069 Walker A/P-loop; other site 226900003070 ATP binding site [chemical binding]; other site 226900003071 Q-loop/lid; other site 226900003072 ABC transporter signature motif; other site 226900003073 Walker B; other site 226900003074 D-loop; other site 226900003075 H-loop/switch region; other site 226900003076 TOBE-like domain; Region: TOBE_3; pfam12857 226900003077 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900003078 Immunity protein 25; Region: Imm25; pfam15571 226900003079 Regulator of ribonuclease activity B; Region: RraB; pfam06877 226900003080 lipoxygenase; Region: PLN02337 226900003081 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 226900003082 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 226900003083 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900003084 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226900003085 putative active site [active] 226900003086 putative metal binding site [ion binding]; other site 226900003087 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 226900003088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900003089 Zn2+ binding site [ion binding]; other site 226900003090 Mg2+ binding site [ion binding]; other site 226900003091 Putative zinc-finger; Region: zf-HC2; pfam13490 226900003092 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 226900003093 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 226900003094 RNA polymerase sigma factor; Provisional; Region: PRK12541 226900003095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900003096 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900003097 DNA binding residues [nucleotide binding] 226900003098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900003099 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900003100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900003101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 226900003102 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 226900003103 active site 226900003104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900003105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003106 dimer interface [polypeptide binding]; other site 226900003107 phosphorylation site [posttranslational modification] 226900003108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003109 ATP binding site [chemical binding]; other site 226900003110 Mg2+ binding site [ion binding]; other site 226900003111 G-X-G motif; other site 226900003112 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900003113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900003114 active site 226900003115 phosphorylation site [posttranslational modification] 226900003116 intermolecular recognition site; other site 226900003117 dimerization interface [polypeptide binding]; other site 226900003118 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900003119 DNA binding site [nucleotide binding] 226900003120 CAAX protease self-immunity; Region: Abi; pfam02517 226900003121 Peptidase family M48; Region: Peptidase_M48; pfam01435 226900003122 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 226900003123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900003124 dimerization interface [polypeptide binding]; other site 226900003125 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900003126 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 226900003127 dimer interface [polypeptide binding]; other site 226900003128 putative CheW interface [polypeptide binding]; other site 226900003129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226900003130 S-layer homology domain; Region: SLH; pfam00395 226900003131 S-layer homology domain; Region: SLH; pfam00395 226900003132 S-layer homology domain; Region: SLH; pfam00395 226900003133 S-layer homology domain; Region: SLH; pfam00395 226900003134 S-layer homology domain; Region: SLH; pfam00395 226900003135 S-layer homology domain; Region: SLH; pfam00395 226900003136 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 226900003137 active site 226900003138 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 226900003139 tetramer interface [polypeptide binding]; other site 226900003140 active site 226900003141 Mg2+/Mn2+ binding site [ion binding]; other site 226900003142 Phosphotransferase enzyme family; Region: APH; pfam01636 226900003143 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 226900003144 active site 226900003145 substrate binding site [chemical binding]; other site 226900003146 ATP binding site [chemical binding]; other site 226900003147 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226900003148 DNA-binding site [nucleotide binding]; DNA binding site 226900003149 RNA-binding motif; other site 226900003150 ComK protein; Region: ComK; pfam06338 226900003151 Uncharacterized conserved protein [Function unknown]; Region: COG0398 226900003152 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900003153 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900003154 Catalytic site [active] 226900003155 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 226900003156 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 226900003157 AAA domain; Region: AAA_22; pfam13401 226900003158 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 226900003159 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 226900003160 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 226900003161 Part of AAA domain; Region: AAA_19; pfam13245 226900003162 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226900003163 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 226900003164 hypothetical protein; Provisional; Region: PRK07758 226900003165 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900003166 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 226900003167 Spore germination protein GerPC; Region: GerPC; pfam10737 226900003168 Spore germination GerPB; Region: GerPB; pfam10803 226900003169 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900003170 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900003171 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 226900003172 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 226900003173 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900003174 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 226900003175 inhibitor-cofactor binding pocket; inhibition site 226900003176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900003177 catalytic residue [active] 226900003178 hypothetical protein; Provisional; Region: PRK13673 226900003179 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 226900003180 ferrochelatase; Provisional; Region: PRK12435 226900003181 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 226900003182 C-terminal domain interface [polypeptide binding]; other site 226900003183 active site 226900003184 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 226900003185 active site 226900003186 N-terminal domain interface [polypeptide binding]; other site 226900003187 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 226900003188 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 226900003189 tetramer interface [polypeptide binding]; other site 226900003190 heme binding pocket [chemical binding]; other site 226900003191 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 226900003192 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 226900003193 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 226900003194 active site 226900003195 catalytic site [active] 226900003196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900003197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900003198 non-specific DNA binding site [nucleotide binding]; other site 226900003199 salt bridge; other site 226900003200 sequence-specific DNA binding site [nucleotide binding]; other site 226900003201 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900003202 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 226900003203 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 226900003204 S1 domain; Region: S1_2; pfam13509 226900003205 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 226900003206 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 226900003207 Domain of unknown function (DUF3941); Region: DUF3941; pfam13081 226900003208 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900003209 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900003210 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900003211 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226900003212 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 226900003213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900003214 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900003215 active site 226900003216 motif I; other site 226900003217 motif II; other site 226900003218 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900003219 YjzC-like protein; Region: YjzC; pfam14168 226900003220 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 226900003221 Clp amino terminal domain; Region: Clp_N; pfam02861 226900003222 Clp amino terminal domain; Region: Clp_N; pfam02861 226900003223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900003224 Walker A motif; other site 226900003225 ATP binding site [chemical binding]; other site 226900003226 Walker B motif; other site 226900003227 arginine finger; other site 226900003228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900003229 Walker A motif; other site 226900003230 ATP binding site [chemical binding]; other site 226900003231 Walker B motif; other site 226900003232 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 226900003233 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 226900003234 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 226900003235 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 226900003236 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900003237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003238 NAD(P) binding site [chemical binding]; other site 226900003239 active site 226900003240 ComZ; Region: ComZ; pfam10815 226900003241 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 226900003242 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 226900003243 dimer interface [polypeptide binding]; other site 226900003244 active site 226900003245 CoA binding pocket [chemical binding]; other site 226900003246 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 226900003247 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 226900003248 dimer interface [polypeptide binding]; other site 226900003249 active site 226900003250 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 226900003251 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 226900003252 similar to Tryptophanyl-tRNA synthetase; EC_number 6.1.1.2 226900003253 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 226900003254 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900003255 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900003256 peptide binding site [polypeptide binding]; other site 226900003257 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900003258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003259 dimer interface [polypeptide binding]; other site 226900003260 conserved gate region; other site 226900003261 putative PBP binding loops; other site 226900003262 ABC-ATPase subunit interface; other site 226900003263 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900003264 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 226900003265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003266 dimer interface [polypeptide binding]; other site 226900003267 conserved gate region; other site 226900003268 putative PBP binding loops; other site 226900003269 ABC-ATPase subunit interface; other site 226900003270 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 226900003271 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226900003272 Walker A/P-loop; other site 226900003273 ATP binding site [chemical binding]; other site 226900003274 Q-loop/lid; other site 226900003275 ABC transporter signature motif; other site 226900003276 Walker B; other site 226900003277 D-loop; other site 226900003278 H-loop/switch region; other site 226900003279 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900003280 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 226900003281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 226900003282 Walker A/P-loop; other site 226900003283 ATP binding site [chemical binding]; other site 226900003284 Q-loop/lid; other site 226900003285 ABC transporter signature motif; other site 226900003286 Walker B; other site 226900003287 D-loop; other site 226900003288 H-loop/switch region; other site 226900003289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 226900003290 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226900003291 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 226900003292 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900003293 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900003294 peptide binding site [polypeptide binding]; other site 226900003295 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 226900003296 putative catalytic residues [active] 226900003297 thiol/disulfide switch; other site 226900003298 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 226900003299 adaptor protein; Provisional; Region: PRK02315 226900003300 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 226900003301 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 226900003302 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900003303 putative active site [active] 226900003304 catalytic site [active] 226900003305 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900003306 putative active site [active] 226900003307 catalytic site [active] 226900003308 Competence protein CoiA-like family; Region: CoiA; cl11541 226900003309 oligoendopeptidase F; Region: pepF; TIGR00181 226900003310 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 226900003311 active site 226900003312 Zn binding site [ion binding]; other site 226900003313 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 226900003314 catalytic residues [active] 226900003315 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 226900003316 apolar tunnel; other site 226900003317 heme binding site [chemical binding]; other site 226900003318 dimerization interface [polypeptide binding]; other site 226900003319 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 226900003320 putative active site [active] 226900003321 putative metal binding residues [ion binding]; other site 226900003322 signature motif; other site 226900003323 putative triphosphate binding site [ion binding]; other site 226900003324 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226900003325 synthetase active site [active] 226900003326 NTP binding site [chemical binding]; other site 226900003327 metal binding site [ion binding]; metal-binding site 226900003328 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 226900003329 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 226900003330 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 226900003331 active site 226900003332 similar to Cell surface protein 226900003333 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 226900003334 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 226900003335 active site 226900003336 metal binding site [ion binding]; metal-binding site 226900003337 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 226900003338 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 226900003339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900003340 active site 226900003341 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900003342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900003343 S-adenosylmethionine binding site [chemical binding]; other site 226900003344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 226900003345 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 226900003346 putative metal binding site; other site 226900003347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900003348 binding surface 226900003349 TPR motif; other site 226900003350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900003351 binding surface 226900003352 TPR motif; other site 226900003353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900003354 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900003355 S-adenosylmethionine binding site [chemical binding]; other site 226900003356 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 226900003357 catalytic residues [active] 226900003358 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 226900003359 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 226900003360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900003361 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 226900003362 active site 226900003363 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 226900003364 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 226900003365 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 226900003366 NAD binding site [chemical binding]; other site 226900003367 substrate binding site [chemical binding]; other site 226900003368 homodimer interface [polypeptide binding]; other site 226900003369 active site 226900003370 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 226900003371 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 226900003372 NADP binding site [chemical binding]; other site 226900003373 active site 226900003374 putative substrate binding site [chemical binding]; other site 226900003375 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 226900003376 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 226900003377 NAD binding site [chemical binding]; other site 226900003378 homotetramer interface [polypeptide binding]; other site 226900003379 homodimer interface [polypeptide binding]; other site 226900003380 substrate binding site [chemical binding]; other site 226900003381 active site 226900003382 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 226900003383 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 226900003384 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 226900003385 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 226900003386 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 226900003387 Part of AAA domain; Region: AAA_19; pfam13245 226900003388 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226900003389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900003390 Coenzyme A binding pocket [chemical binding]; other site 226900003391 hypothetical protein; Provisional; Region: PRK13679 226900003392 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 226900003393 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 226900003394 Putative esterase; Region: Esterase; pfam00756 226900003395 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900003396 EamA-like transporter family; Region: EamA; pfam00892 226900003397 EamA-like transporter family; Region: EamA; pfam00892 226900003398 Bacterial PH domain; Region: bPH_4; pfam06713 226900003399 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 226900003400 Pectate lyase; Region: Pectate_lyase; pfam03211 226900003401 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 226900003402 Na binding site [ion binding]; other site 226900003403 anthranilate synthase component I; Provisional; Region: PRK13570 226900003404 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 226900003405 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 226900003406 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 226900003407 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 226900003408 glutamine binding [chemical binding]; other site 226900003409 catalytic triad [active] 226900003410 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 226900003411 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 226900003412 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 226900003413 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 226900003414 active site 226900003415 ribulose/triose binding site [chemical binding]; other site 226900003416 phosphate binding site [ion binding]; other site 226900003417 substrate (anthranilate) binding pocket [chemical binding]; other site 226900003418 product (indole) binding pocket [chemical binding]; other site 226900003419 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 226900003420 active site 226900003421 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 226900003422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900003423 catalytic residue [active] 226900003424 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 226900003425 substrate binding site [chemical binding]; other site 226900003426 active site 226900003427 catalytic residues [active] 226900003428 heterodimer interface [polypeptide binding]; other site 226900003429 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 226900003430 L-lactate permease; Region: Lactate_perm; cl00701 226900003431 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 226900003432 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 226900003433 Double zinc ribbon; Region: DZR; pfam12773 226900003434 Predicted membrane protein [Function unknown]; Region: COG4640 226900003435 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 226900003436 YARHG domain; Region: YARHG; pfam13308 226900003437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900003438 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 226900003439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900003440 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226900003441 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 226900003442 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 226900003443 NADPH bind site [chemical binding]; other site 226900003444 putative FMN binding site [chemical binding]; other site 226900003445 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 226900003446 putative FMN binding site [chemical binding]; other site 226900003447 NADPH bind site [chemical binding]; other site 226900003448 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 226900003449 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 226900003450 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 226900003451 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 226900003452 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 226900003453 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226900003454 E3 interaction surface; other site 226900003455 lipoyl attachment site [posttranslational modification]; other site 226900003456 e3 binding domain; Region: E3_binding; pfam02817 226900003457 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 226900003458 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 226900003459 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 226900003460 TPP-binding site [chemical binding]; other site 226900003461 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 226900003462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900003463 salt bridge; other site 226900003464 non-specific DNA binding site [nucleotide binding]; other site 226900003465 sequence-specific DNA binding site [nucleotide binding]; other site 226900003466 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 226900003467 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 226900003468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900003469 Walker A/P-loop; other site 226900003470 ATP binding site [chemical binding]; other site 226900003471 AAA domain; Region: AAA_21; pfam13304 226900003472 Protein of unknown function (DUF4435); Region: DUF4435; pfam14491 226900003473 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900003474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900003475 ATP binding site [chemical binding]; other site 226900003476 putative Mg++ binding site [ion binding]; other site 226900003477 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 226900003478 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 226900003479 Protein of unknown function DUF91; Region: DUF91; cl00709 226900003480 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 226900003481 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226900003482 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226900003483 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226900003484 Int/Topo IB signature motif; other site 226900003485 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 226900003486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900003487 S-adenosylmethionine binding site [chemical binding]; other site 226900003488 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900003489 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900003490 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 226900003491 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900003492 Catalytic site [active] 226900003493 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 226900003494 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 226900003495 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 226900003496 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 226900003497 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900003498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900003499 non-specific DNA binding site [nucleotide binding]; other site 226900003500 salt bridge; other site 226900003501 sequence-specific DNA binding site [nucleotide binding]; other site 226900003502 Anti-repressor SinI; Region: SinI; pfam08671 226900003503 Anti-repressor SinI; Region: SinI; pfam08671 226900003504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 226900003505 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 226900003506 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 226900003507 NAD(P) binding site [chemical binding]; other site 226900003508 catalytic residues [active] 226900003509 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 226900003510 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 226900003511 Walker A/P-loop; other site 226900003512 ATP binding site [chemical binding]; other site 226900003513 Q-loop/lid; other site 226900003514 ABC transporter signature motif; other site 226900003515 Walker B; other site 226900003516 D-loop; other site 226900003517 H-loop/switch region; other site 226900003518 TOBE domain; Region: TOBE_2; pfam08402 226900003519 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 226900003520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003521 dimer interface [polypeptide binding]; other site 226900003522 conserved gate region; other site 226900003523 putative PBP binding loops; other site 226900003524 ABC-ATPase subunit interface; other site 226900003525 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 226900003526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003527 dimer interface [polypeptide binding]; other site 226900003528 conserved gate region; other site 226900003529 putative PBP binding loops; other site 226900003530 ABC-ATPase subunit interface; other site 226900003531 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 226900003532 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 226900003533 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 226900003534 active site 226900003535 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 226900003536 MMPL family; Region: MMPL; cl14618 226900003537 MMPL family; Region: MMPL; cl14618 226900003538 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 226900003539 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 226900003540 active site 226900003541 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 226900003542 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 226900003543 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 226900003544 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 226900003545 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226900003546 Cysteine-rich domain; Region: CCG; pfam02754 226900003547 Cysteine-rich domain; Region: CCG; pfam02754 226900003548 FAD binding domain; Region: FAD_binding_4; pfam01565 226900003549 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 226900003550 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 226900003551 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 226900003552 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 226900003553 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 226900003554 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 226900003555 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 226900003556 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 226900003557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900003558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900003559 active site 226900003560 phosphorylation site [posttranslational modification] 226900003561 intermolecular recognition site; other site 226900003562 dimerization interface [polypeptide binding]; other site 226900003563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900003564 DNA binding site [nucleotide binding] 226900003565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900003566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900003567 dimerization interface [polypeptide binding]; other site 226900003568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003569 dimer interface [polypeptide binding]; other site 226900003570 phosphorylation site [posttranslational modification] 226900003571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003572 ATP binding site [chemical binding]; other site 226900003573 Mg2+ binding site [ion binding]; other site 226900003574 G-X-G motif; other site 226900003575 Transcriptional regulators [Transcription]; Region: FadR; COG2186 226900003576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900003577 DNA-binding site [nucleotide binding]; DNA binding site 226900003578 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 226900003579 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 226900003580 Cysteine-rich domain; Region: CCG; pfam02754 226900003581 Cysteine-rich domain; Region: CCG; pfam02754 226900003582 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 226900003583 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 226900003584 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226900003585 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 226900003586 Uncharacterized conserved protein [Function unknown]; Region: COG1556 226900003587 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 226900003588 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 226900003589 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 226900003590 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 226900003591 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 226900003592 Cation transport protein; Region: TrkH; cl17365 226900003593 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 226900003594 Cation transport protein; Region: TrkH; cl17365 226900003595 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900003596 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 226900003597 dimer interaction site [polypeptide binding]; other site 226900003598 substrate-binding tunnel; other site 226900003599 active site 226900003600 catalytic site [active] 226900003601 substrate binding site [chemical binding]; other site 226900003602 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 226900003603 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 226900003604 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 226900003605 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 226900003606 NAD(P) binding site [chemical binding]; other site 226900003607 active site 226900003608 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 226900003609 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 226900003610 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 226900003611 FAD dependent oxidoreductase; Region: DAO; pfam01266 226900003612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900003613 Cation transport protein; Region: TrkH; cl17365 226900003614 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 226900003615 Cation transport protein; Region: TrkH; pfam02386 226900003616 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 226900003617 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 226900003618 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 226900003619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900003620 Walker A/P-loop; other site 226900003621 ATP binding site [chemical binding]; other site 226900003622 Q-loop/lid; other site 226900003623 ABC transporter signature motif; other site 226900003624 Walker B; other site 226900003625 D-loop; other site 226900003626 H-loop/switch region; other site 226900003627 TOBE domain; Region: TOBE_2; pfam08402 226900003628 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 226900003629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003630 dimer interface [polypeptide binding]; other site 226900003631 conserved gate region; other site 226900003632 putative PBP binding loops; other site 226900003633 ABC-ATPase subunit interface; other site 226900003634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900003635 dimer interface [polypeptide binding]; other site 226900003636 conserved gate region; other site 226900003637 putative PBP binding loops; other site 226900003638 ABC-ATPase subunit interface; other site 226900003639 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 226900003640 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 226900003641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900003642 motif II; other site 226900003643 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 226900003644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900003645 catalytic residue [active] 226900003646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900003647 NAD(P) binding site [chemical binding]; other site 226900003648 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 226900003649 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226900003650 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 226900003651 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 226900003652 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900003653 heme-binding site [chemical binding]; other site 226900003654 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 226900003655 Leucine rich repeat; Region: LRR_8; pfam13855 226900003656 Leucine rich repeat; Region: LRR_8; pfam13855 226900003657 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003658 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003659 Leucine rich repeat; Region: LRR_8; pfam13855 226900003660 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 226900003661 LRR adjacent; Region: LRR_adjacent; pfam08191 226900003662 S-layer homology domain; Region: SLH; pfam00395 226900003663 S-layer homology domain; Region: SLH; pfam00395 226900003664 S-layer homology domain; Region: SLH; pfam00395 226900003665 similar to Methylthioribose salvage protein ( aldolase) 226900003666 FOG: CBS domain [General function prediction only]; Region: COG0517 226900003667 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 226900003668 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 226900003669 NodB motif; other site 226900003670 putative active site [active] 226900003671 putative catalytic site [active] 226900003672 Zn binding site [ion binding]; other site 226900003673 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900003674 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 226900003675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003676 dimer interface [polypeptide binding]; other site 226900003677 phosphorylation site [posttranslational modification] 226900003678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003679 ATP binding site [chemical binding]; other site 226900003680 Mg2+ binding site [ion binding]; other site 226900003681 G-X-G motif; other site 226900003682 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900003683 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900003684 dimerization interface [polypeptide binding]; other site 226900003685 putative DNA binding site [nucleotide binding]; other site 226900003686 putative Zn2+ binding site [ion binding]; other site 226900003687 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 226900003688 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 226900003689 active site 226900003690 Zn binding site [ion binding]; other site 226900003691 DinB superfamily; Region: DinB_2; pfam12867 226900003692 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 226900003693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900003694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003695 dimer interface [polypeptide binding]; other site 226900003696 phosphorylation site [posttranslational modification] 226900003697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003698 ATP binding site [chemical binding]; other site 226900003699 Mg2+ binding site [ion binding]; other site 226900003700 G-X-G motif; other site 226900003701 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 226900003702 Ligand Binding Site [chemical binding]; other site 226900003703 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 226900003704 active site 226900003705 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 226900003706 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 226900003707 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 226900003708 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 226900003709 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 226900003710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900003711 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900003712 Coenzyme A binding pocket [chemical binding]; other site 226900003713 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 226900003714 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 226900003715 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 226900003716 Class I ribonucleotide reductase; Region: RNR_I; cd01679 226900003717 active site 226900003718 dimer interface [polypeptide binding]; other site 226900003719 catalytic residues [active] 226900003720 effector binding site; other site 226900003721 R2 peptide binding site; other site 226900003722 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 226900003723 dimer interface [polypeptide binding]; other site 226900003724 putative radical transfer pathway; other site 226900003725 diiron center [ion binding]; other site 226900003726 tyrosyl radical; other site 226900003727 Predicted transcriptional regulators [Transcription]; Region: COG1725 226900003728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900003729 DNA-binding site [nucleotide binding]; DNA binding site 226900003730 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226900003731 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900003732 Walker A/P-loop; other site 226900003733 ATP binding site [chemical binding]; other site 226900003734 Q-loop/lid; other site 226900003735 ABC transporter signature motif; other site 226900003736 Walker B; other site 226900003737 D-loop; other site 226900003738 H-loop/switch region; other site 226900003739 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900003740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900003741 Walker A/P-loop; other site 226900003742 ATP binding site [chemical binding]; other site 226900003743 Q-loop/lid; other site 226900003744 ABC transporter signature motif; other site 226900003745 Walker B; other site 226900003746 D-loop; other site 226900003747 H-loop/switch region; other site 226900003748 Acyltransferase family; Region: Acyl_transf_3; cl19154 226900003749 CAAX protease self-immunity; Region: Abi; pfam02517 226900003750 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 226900003751 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 226900003752 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900003753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900003754 putative DNA binding site [nucleotide binding]; other site 226900003755 putative Zn2+ binding site [ion binding]; other site 226900003756 AsnC family; Region: AsnC_trans_reg; pfam01037 226900003757 Uncharacterized conserved protein [Function unknown]; Region: COG2128 226900003758 Glycosyl transferase family 90; Region: Glyco_transf_90; pfam05686 226900003759 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900003760 catalytic triad [active] 226900003761 conserved cis-peptide bond; other site 226900003762 SseB protein N-terminal domain; Region: SseB; pfam07179 226900003763 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 226900003764 dimer interface [polypeptide binding]; other site 226900003765 catalytic triad [active] 226900003766 Nitronate monooxygenase; Region: NMO; pfam03060 226900003767 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 226900003768 FMN binding site [chemical binding]; other site 226900003769 substrate binding site [chemical binding]; other site 226900003770 putative catalytic residue [active] 226900003771 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 226900003772 DltD N-terminal region; Region: DltD_N; pfam04915 226900003773 DltD central region; Region: DltD_M; pfam04918 226900003774 DltD C-terminal region; Region: DltD_C; pfam04914 226900003775 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 226900003776 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 226900003777 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 226900003778 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 226900003779 acyl-activating enzyme (AAE) consensus motif; other site 226900003780 AMP binding site [chemical binding]; other site 226900003781 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 226900003782 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900003783 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 226900003784 metal binding site [ion binding]; metal-binding site 226900003785 dimer interface [polypeptide binding]; other site 226900003786 flavodoxin; Provisional; Region: PRK06756 226900003787 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 226900003788 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 226900003789 Phosphotransferase enzyme family; Region: APH; pfam01636 226900003790 active site 226900003791 substrate binding site [chemical binding]; other site 226900003792 ATP binding site [chemical binding]; other site 226900003793 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 226900003794 multidrug efflux protein; Reviewed; Region: PRK01766 226900003795 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 226900003796 cation binding site [ion binding]; other site 226900003797 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 226900003798 Thioredoxin; Region: Thioredoxin_9; pfam14595 226900003799 Regulatory protein YrvL; Region: YrvL; pfam14184 226900003800 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900003801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900003802 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 226900003803 Cation transport protein; Region: TrkH; cl17365 226900003804 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 226900003805 Cation transport protein; Region: TrkH; pfam02386 226900003806 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 226900003807 hypothetical protein; Provisional; Region: PRK03094 226900003808 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 226900003809 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 226900003810 homodimer interface [polypeptide binding]; other site 226900003811 substrate-cofactor binding pocket; other site 226900003812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900003813 catalytic residue [active] 226900003814 similar to Acetolactate synthase large subunit; EC_number 4.1.3.18 226900003815 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 226900003816 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 226900003817 putative valine binding site [chemical binding]; other site 226900003818 dimer interface [polypeptide binding]; other site 226900003819 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 226900003820 ketol-acid reductoisomerase; Provisional; Region: PRK05479 226900003821 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 226900003822 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 226900003823 2-isopropylmalate synthase; Validated; Region: PRK00915 226900003824 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 226900003825 active site 226900003826 catalytic residues [active] 226900003827 metal binding site [ion binding]; metal-binding site 226900003828 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 226900003829 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 226900003830 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 226900003831 substrate binding site [chemical binding]; other site 226900003832 ligand binding site [chemical binding]; other site 226900003833 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 226900003834 substrate binding site [chemical binding]; other site 226900003835 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 226900003836 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 226900003837 dimer interface [polypeptide binding]; other site 226900003838 motif 1; other site 226900003839 active site 226900003840 motif 2; other site 226900003841 motif 3; other site 226900003842 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 226900003843 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 226900003844 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 226900003845 histidinol dehydrogenase; Region: hisD; TIGR00069 226900003846 NAD binding site [chemical binding]; other site 226900003847 dimerization interface [polypeptide binding]; other site 226900003848 product binding site; other site 226900003849 substrate binding site [chemical binding]; other site 226900003850 zinc binding site [ion binding]; other site 226900003851 catalytic residues [active] 226900003852 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 226900003853 putative active site pocket [active] 226900003854 4-fold oligomerization interface [polypeptide binding]; other site 226900003855 metal binding residues [ion binding]; metal-binding site 226900003856 3-fold/trimer interface [polypeptide binding]; other site 226900003857 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 226900003858 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 226900003859 putative active site [active] 226900003860 oxyanion strand; other site 226900003861 catalytic triad [active] 226900003862 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 226900003863 catalytic residues [active] 226900003864 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 226900003865 substrate binding site [chemical binding]; other site 226900003866 glutamase interaction surface [polypeptide binding]; other site 226900003867 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 226900003868 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 226900003869 metal binding site [ion binding]; metal-binding site 226900003870 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 226900003871 dimer interface [polypeptide binding]; other site 226900003872 active site 226900003873 histidinol-phosphatase; Provisional; Region: PRK07328 226900003874 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 226900003875 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 226900003876 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 226900003877 NAD binding site [chemical binding]; other site 226900003878 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 226900003879 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 226900003880 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226900003881 Sulfatase; Region: Sulfatase; pfam00884 226900003882 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 226900003883 diaminopimelate decarboxylase; Region: lysA; TIGR01048 226900003884 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 226900003885 active site 226900003886 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900003887 substrate binding site [chemical binding]; other site 226900003888 catalytic residues [active] 226900003889 dimer interface [polypeptide binding]; other site 226900003890 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 226900003891 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 226900003892 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 226900003893 Active Sites [active] 226900003894 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 226900003895 ATP-sulfurylase; Region: ATPS; cd00517 226900003896 active site 226900003897 HXXH motif; other site 226900003898 flexible loop; other site 226900003899 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 226900003900 ligand-binding site [chemical binding]; other site 226900003901 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 226900003902 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 226900003903 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 226900003904 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 226900003905 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 226900003906 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 226900003907 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 226900003908 active site 226900003909 SAM binding site [chemical binding]; other site 226900003910 homodimer interface [polypeptide binding]; other site 226900003911 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 226900003912 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 226900003913 putative active site [active] 226900003914 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 226900003915 putative active site [active] 226900003916 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 226900003917 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 226900003918 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 226900003919 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 226900003920 Na2 binding site [ion binding]; other site 226900003921 putative substrate binding site 1 [chemical binding]; other site 226900003922 Na binding site 1 [ion binding]; other site 226900003923 putative substrate binding site 2 [chemical binding]; other site 226900003924 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 226900003925 Protein of unknown function (DUF342); Region: DUF342; cl19219 226900003926 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900003927 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 226900003928 Protein of unknown function (DUF402); Region: DUF402; cl00979 226900003929 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 226900003930 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226900003931 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 226900003932 Vpu protein; Region: Vpu; pfam00558 226900003933 PspA/IM30 family; Region: PspA_IM30; pfam04012 226900003934 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226900003935 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 226900003936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900003937 Histidine kinase; Region: HisKA_3; pfam07730 226900003938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003939 ATP binding site [chemical binding]; other site 226900003940 Mg2+ binding site [ion binding]; other site 226900003941 G-X-G motif; other site 226900003942 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900003943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900003944 active site 226900003945 phosphorylation site [posttranslational modification] 226900003946 intermolecular recognition site; other site 226900003947 dimerization interface [polypeptide binding]; other site 226900003948 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900003949 DNA binding residues [nucleotide binding] 226900003950 dimerization interface [polypeptide binding]; other site 226900003951 Protein of unknown function (DUF3992); Region: DUF3922; pfam13059 226900003952 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 226900003953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900003954 S-adenosylmethionine binding site [chemical binding]; other site 226900003955 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 226900003956 Peptidase family M50; Region: Peptidase_M50; pfam02163 226900003957 active site 226900003958 putative substrate binding region [chemical binding]; other site 226900003959 hypothetical protein; Provisional; Region: PRK06770 226900003960 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 226900003961 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 226900003962 heme-binding site [chemical binding]; other site 226900003963 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 226900003964 FAD binding pocket [chemical binding]; other site 226900003965 FAD binding motif [chemical binding]; other site 226900003966 phosphate binding motif [ion binding]; other site 226900003967 beta-alpha-beta structure motif; other site 226900003968 NAD binding pocket [chemical binding]; other site 226900003969 Heme binding pocket [chemical binding]; other site 226900003970 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226900003971 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900003972 ligand binding site [chemical binding]; other site 226900003973 flexible hinge region; other site 226900003974 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 226900003975 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900003976 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 226900003977 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 226900003978 TIGR00153 family protein; Region: TIGR00153 226900003979 Transglycosylase; Region: Transgly; pfam00912 226900003980 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226900003981 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900003982 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 226900003983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900003984 putative active site [active] 226900003985 heme pocket [chemical binding]; other site 226900003986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900003987 dimer interface [polypeptide binding]; other site 226900003988 phosphorylation site [posttranslational modification] 226900003989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900003990 ATP binding site [chemical binding]; other site 226900003991 Mg2+ binding site [ion binding]; other site 226900003992 G-X-G motif; other site 226900003993 Protein of unknown function DUF72; Region: DUF72; pfam01904 226900003994 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 226900003995 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226900003996 active site 226900003997 DNA binding site [nucleotide binding] 226900003998 Int/Topo IB signature motif; other site 226900003999 similar to Two component system histidine kinase; EC_number 2.7.3.- 226900004000 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 226900004001 Predicted integral membrane protein [Function unknown]; Region: COG0392 226900004002 Uncharacterized conserved protein [Function unknown]; Region: COG2898 226900004003 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 226900004004 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 226900004005 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 226900004006 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 226900004007 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 226900004008 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900004009 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900004010 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 226900004011 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 226900004012 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 226900004013 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 226900004014 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900004015 RNA binding surface [nucleotide binding]; other site 226900004016 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 226900004017 active site 226900004018 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226900004019 catalytic residues [active] 226900004020 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 226900004021 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900004022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004023 active site 226900004024 phosphorylation site [posttranslational modification] 226900004025 intermolecular recognition site; other site 226900004026 dimerization interface [polypeptide binding]; other site 226900004027 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900004028 DNA binding site [nucleotide binding] 226900004029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 226900004030 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900004031 dimerization interface [polypeptide binding]; other site 226900004032 PAS domain; Region: PAS; smart00091 226900004033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900004034 dimer interface [polypeptide binding]; other site 226900004035 phosphorylation site [posttranslational modification] 226900004036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004037 ATP binding site [chemical binding]; other site 226900004038 Mg2+ binding site [ion binding]; other site 226900004039 G-X-G motif; other site 226900004040 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 226900004041 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226900004042 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900004043 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 226900004044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226900004045 Predicted membrane protein [Function unknown]; Region: COG3601 226900004046 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 226900004047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 226900004048 Helix-turn-helix domain; Region: HTH_40; pfam14493 226900004049 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900004050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900004051 ATP binding site [chemical binding]; other site 226900004052 putative Mg++ binding site [ion binding]; other site 226900004053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900004054 nucleotide binding region [chemical binding]; other site 226900004055 ATP-binding site [chemical binding]; other site 226900004056 CAAX protease self-immunity; Region: Abi; pfam02517 226900004057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226900004058 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900004059 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226900004060 putative active site [active] 226900004061 putative metal binding site [ion binding]; other site 226900004062 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900004063 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 226900004064 DNA binding residues [nucleotide binding] 226900004065 B12 binding domain; Region: B12-binding_2; pfam02607 226900004066 adaptor protein; Provisional; Region: PRK02899 226900004067 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 226900004068 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 226900004069 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 226900004070 NAD(P) binding site [chemical binding]; other site 226900004071 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 226900004072 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900004073 amidase catalytic site [active] 226900004074 Zn binding residues [ion binding]; other site 226900004075 substrate binding site [chemical binding]; other site 226900004076 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 226900004077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 226900004078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900004079 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 226900004080 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 226900004081 active site 226900004082 homotetramer interface [polypeptide binding]; other site 226900004083 homodimer interface [polypeptide binding]; other site 226900004084 cytidylate kinase; Provisional; Region: cmk; PRK00023 226900004085 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 226900004086 AAA domain; Region: AAA_18; pfam13238 226900004087 CMP-binding site; other site 226900004088 The sites determining sugar specificity; other site 226900004089 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 226900004090 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 226900004091 RNA binding site [nucleotide binding]; other site 226900004092 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 226900004093 RNA binding site [nucleotide binding]; other site 226900004094 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 226900004095 RNA binding site [nucleotide binding]; other site 226900004096 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226900004097 RNA binding site [nucleotide binding]; other site 226900004098 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 226900004099 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 226900004100 homotetramer interface [polypeptide binding]; other site 226900004101 FMN binding site [chemical binding]; other site 226900004102 homodimer contacts [polypeptide binding]; other site 226900004103 putative active site [active] 226900004104 putative substrate binding site [chemical binding]; other site 226900004105 YpzI-like protein; Region: YpzI; pfam14140 226900004106 YIEGIA protein; Region: YIEGIA; pfam14045 226900004107 GTP-binding protein Der; Reviewed; Region: PRK00093 226900004108 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 226900004109 G1 box; other site 226900004110 GTP/Mg2+ binding site [chemical binding]; other site 226900004111 Switch I region; other site 226900004112 G2 box; other site 226900004113 Switch II region; other site 226900004114 G3 box; other site 226900004115 G4 box; other site 226900004116 G5 box; other site 226900004117 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 226900004118 G1 box; other site 226900004119 GTP/Mg2+ binding site [chemical binding]; other site 226900004120 Switch I region; other site 226900004121 G2 box; other site 226900004122 G3 box; other site 226900004123 Switch II region; other site 226900004124 G4 box; other site 226900004125 G5 box; other site 226900004126 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 226900004127 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 226900004128 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 226900004129 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 226900004130 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 226900004131 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 226900004132 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 226900004133 histone-like DNA-binding protein HU; Region: HU; cd13831 226900004134 dimer interface [polypeptide binding]; other site 226900004135 DNA binding site [nucleotide binding] 226900004136 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 226900004137 homodecamer interface [polypeptide binding]; other site 226900004138 active site 226900004139 putative catalytic site residues [active] 226900004140 zinc binding site [ion binding]; other site 226900004141 GTP-CH-I/GFRP interaction surface; other site 226900004142 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 226900004143 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 226900004144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900004145 S-adenosylmethionine binding site [chemical binding]; other site 226900004146 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 226900004147 substrate binding pocket [chemical binding]; other site 226900004148 chain length determination region; other site 226900004149 substrate-Mg2+ binding site; other site 226900004150 catalytic residues [active] 226900004151 aspartate-rich region 1; other site 226900004152 active site lid residues [active] 226900004153 aspartate-rich region 2; other site 226900004154 Nucleoside diphosphate kinase; Region: NDK; pfam00334 226900004155 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 226900004156 active site 226900004157 multimer interface [polypeptide binding]; other site 226900004158 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 226900004159 Tetramer interface [polypeptide binding]; other site 226900004160 active site 226900004161 FMN-binding site [chemical binding]; other site 226900004162 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 226900004163 active site 226900004164 dimer interface [polypeptide binding]; other site 226900004165 metal binding site [ion binding]; metal-binding site 226900004166 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 226900004167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900004168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004169 homodimer interface [polypeptide binding]; other site 226900004170 catalytic residue [active] 226900004171 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 226900004172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900004173 binding surface 226900004174 TPR motif; other site 226900004175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900004176 binding surface 226900004177 TPR motif; other site 226900004178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900004179 binding surface 226900004180 TPR motif; other site 226900004181 hypothetical protein; Provisional; Region: PRK03636 226900004182 UPF0302 domain; Region: UPF0302; pfam08864 226900004183 IDEAL domain; Region: IDEAL; pfam08858 226900004184 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 226900004185 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 226900004186 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 226900004187 iron-sulfur cluster [ion binding]; other site 226900004188 [2Fe-2S] cluster binding site [ion binding]; other site 226900004189 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 226900004190 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 226900004191 interchain domain interface [polypeptide binding]; other site 226900004192 intrachain domain interface; other site 226900004193 heme bH binding site [chemical binding]; other site 226900004194 Qi binding site; other site 226900004195 heme bL binding site [chemical binding]; other site 226900004196 Qo binding site; other site 226900004197 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 226900004198 interchain domain interface [polypeptide binding]; other site 226900004199 intrachain domain interface; other site 226900004200 Qi binding site; other site 226900004201 Qo binding site; other site 226900004202 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 226900004203 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 226900004204 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 226900004205 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 226900004206 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 226900004207 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 226900004208 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 226900004209 active site 226900004210 Fe-S cluster binding site [ion binding]; other site 226900004211 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900004212 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900004213 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900004214 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226900004215 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 226900004216 homodimer interface [polypeptide binding]; other site 226900004217 metal binding site [ion binding]; metal-binding site 226900004218 dihydrodipicolinate reductase; Provisional; Region: PRK00048 226900004219 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 226900004220 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 226900004221 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 226900004222 active site 226900004223 dimer interfaces [polypeptide binding]; other site 226900004224 catalytic residues [active] 226900004225 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 226900004226 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 226900004227 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 226900004228 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 226900004229 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 226900004230 active site 226900004231 NTP binding site [chemical binding]; other site 226900004232 metal binding triad [ion binding]; metal-binding site 226900004233 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 226900004234 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 226900004235 Biotin operon repressor [Transcription]; Region: BirA; COG1654 226900004236 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 226900004237 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 226900004238 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 226900004239 Cupredoxin superfamily; Region: Cupredoxin; cl19115 226900004240 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 226900004241 oligomerization interface [polypeptide binding]; other site 226900004242 active site 226900004243 metal binding site [ion binding]; metal-binding site 226900004244 Pantoate-beta-alanine ligase; Region: PanC; cd00560 226900004245 active site 226900004246 ATP-binding site [chemical binding]; other site 226900004247 pantoate-binding site; other site 226900004248 HXXH motif; other site 226900004249 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 226900004250 tetramerization interface [polypeptide binding]; other site 226900004251 active site 226900004252 similar to ATP-dependent helicase, DinG family 226900004253 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 226900004254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 226900004255 aspartate aminotransferase; Provisional; Region: PRK05764 226900004256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900004257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004258 homodimer interface [polypeptide binding]; other site 226900004259 catalytic residue [active] 226900004260 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 226900004261 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 226900004262 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 226900004263 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 226900004264 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226900004265 minor groove reading motif; other site 226900004266 helix-hairpin-helix signature motif; other site 226900004267 substrate binding pocket [chemical binding]; other site 226900004268 active site 226900004269 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900004270 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226900004271 Interdomain contacts; other site 226900004272 Cytokine receptor motif; other site 226900004273 Transposase IS200 like; Region: Y1_Tnp; pfam01797 226900004274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 226900004275 Probable transposase; Region: OrfB_IS605; pfam01385 226900004276 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900004277 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900004278 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 226900004279 Transglycosylase; Region: Transgly; pfam00912 226900004280 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 226900004281 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 226900004282 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 226900004283 YppF-like protein; Region: YppF; pfam14178 226900004284 YppG-like protein; Region: YppG; pfam14179 226900004285 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 226900004286 hypothetical protein; Provisional; Region: PRK13660 226900004287 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 226900004288 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 226900004289 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 226900004290 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 226900004291 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 226900004292 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 226900004293 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 226900004294 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 226900004295 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 226900004296 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 226900004297 active site 226900004298 Zn binding site [ion binding]; other site 226900004299 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900004300 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900004301 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 226900004302 active site 226900004303 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900004304 active site 226900004305 Sulfate transporter family; Region: Sulfate_transp; cl19250 226900004306 xanthine permease; Region: pbuX; TIGR03173 226900004307 Predicted membrane protein [Function unknown]; Region: COG2311 226900004308 Protein of unknown function (DUF418); Region: DUF418; pfam04235 226900004309 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 226900004310 G1 box; other site 226900004311 GTP/Mg2+ binding site [chemical binding]; other site 226900004312 G2 box; other site 226900004313 Switch I region; other site 226900004314 G3 box; other site 226900004315 Switch II region; other site 226900004316 G4 box; other site 226900004317 G5 box; other site 226900004318 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 226900004319 G1 box; other site 226900004320 GTP/Mg2+ binding site [chemical binding]; other site 226900004321 G2 box; other site 226900004322 Switch I region; other site 226900004323 G3 box; other site 226900004324 Switch II region; other site 226900004325 G4 box; other site 226900004326 G5 box; other site 226900004327 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 226900004328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004329 Coenzyme A binding pocket [chemical binding]; other site 226900004330 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 226900004331 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 226900004332 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 226900004333 active site residue [active] 226900004334 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 226900004335 active site residue [active] 226900004336 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 226900004337 Predicted membrane protein [Function unknown]; Region: COG3766 226900004338 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 226900004339 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 226900004340 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 226900004341 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900004342 5'-3' exonuclease; Region: 53EXOc; smart00475 226900004343 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 226900004344 active site 226900004345 metal binding site 1 [ion binding]; metal-binding site 226900004346 putative 5' ssDNA interaction site; other site 226900004347 metal binding site 3; metal-binding site 226900004348 metal binding site 2 [ion binding]; metal-binding site 226900004349 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 226900004350 putative DNA binding site [nucleotide binding]; other site 226900004351 putative metal binding site [ion binding]; other site 226900004352 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 226900004353 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 226900004354 Chain length determinant protein; Region: Wzz; pfam02706 226900004355 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 226900004356 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226900004357 Bacterial sugar transferase; Region: Bac_transf; pfam02397 226900004358 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226900004359 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226900004360 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 226900004361 O-Antigen ligase; Region: Wzy_C; pfam04932 226900004362 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900004363 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 226900004364 active site 226900004365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226900004366 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 226900004367 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226900004368 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004369 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004370 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004371 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004372 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004373 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004374 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004375 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004376 Domain of unknown function DUF11; Region: DUF11; cl17728 226900004377 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004378 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004379 Domain of unknown function DUF11; Region: DUF11; cl17728 226900004380 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004381 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004382 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004383 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004384 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004385 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004386 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004387 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004388 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004389 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004390 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004391 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004392 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004393 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004394 Domain of unknown function DUF11; Region: DUF11; cl17728 226900004395 Domain of unknown function DUF11; Region: DUF11; cl17728 226900004396 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004397 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004398 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900004399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004400 Coenzyme A binding pocket [chemical binding]; other site 226900004401 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900004402 catalytic triad [active] 226900004403 conserved cis-peptide bond; other site 226900004404 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900004405 EamA-like transporter family; Region: EamA; pfam00892 226900004406 EamA-like transporter family; Region: EamA; pfam00892 226900004407 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 226900004408 RNA/DNA hybrid binding site [nucleotide binding]; other site 226900004409 active site 226900004410 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 226900004411 active site 226900004412 catalytic residues [active] 226900004413 QueT transporter; Region: QueT; pfam06177 226900004414 hypothetical protein; Validated; Region: PRK07708 226900004415 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 226900004416 RNA/DNA hybrid binding site [nucleotide binding]; other site 226900004417 active site 226900004418 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 226900004419 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 226900004420 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226900004421 DNA-binding site [nucleotide binding]; DNA binding site 226900004422 RNA-binding motif; other site 226900004423 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 226900004424 LysE type translocator; Region: LysE; cl00565 226900004425 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 226900004426 Protein of unknown function, DUF485; Region: DUF485; pfam04341 226900004427 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 226900004428 Na binding site [ion binding]; other site 226900004429 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 226900004430 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900004431 inhibitor-cofactor binding pocket; inhibition site 226900004432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004433 catalytic residue [active] 226900004434 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 226900004435 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 226900004436 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 226900004437 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900004438 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 226900004439 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900004440 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 226900004441 DNA binding residues [nucleotide binding] 226900004442 drug binding residues [chemical binding]; other site 226900004443 dimer interface [polypeptide binding]; other site 226900004444 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 226900004445 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 226900004446 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 226900004447 Predicted membrane protein [Function unknown]; Region: COG2323 226900004448 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900004449 putative active site [active] 226900004450 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 226900004451 dimer interface [polypeptide binding]; other site 226900004452 FMN binding site [chemical binding]; other site 226900004453 NADPH bind site [chemical binding]; other site 226900004454 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900004455 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900004456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004457 putative substrate translocation pore; other site 226900004458 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900004459 bacterial Hfq-like; Region: Hfq; cd01716 226900004460 hexamer interface [polypeptide binding]; other site 226900004461 Sm1 motif; other site 226900004462 RNA binding site [nucleotide binding]; other site 226900004463 Sm2 motif; other site 226900004464 HD domain; Region: HD_3; pfam13023 226900004465 flagellar motor protein MotP; Reviewed; Region: PRK06743 226900004466 flagellar motor protein MotS; Reviewed; Region: PRK06742 226900004467 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226900004468 ligand binding site [chemical binding]; other site 226900004469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004470 active site 226900004471 phosphorylation site [posttranslational modification] 226900004472 intermolecular recognition site; other site 226900004473 dimerization interface [polypeptide binding]; other site 226900004474 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 226900004475 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 226900004476 putative binding surface; other site 226900004477 active site 226900004478 P2 response regulator binding domain; Region: P2; pfam07194 226900004479 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 226900004480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004481 ATP binding site [chemical binding]; other site 226900004482 Mg2+ binding site [ion binding]; other site 226900004483 G-X-G motif; other site 226900004484 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 226900004485 flagellar motor switch protein; Reviewed; Region: PRK06782 226900004486 CheC-like family; Region: CheC; pfam04509 226900004487 CheC-like family; Region: CheC; pfam04509 226900004488 CheC-like family; Region: CheC; pfam04509 226900004489 CheC-like family; Region: CheC; pfam04509 226900004490 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 226900004491 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 226900004492 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 226900004493 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 226900004494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900004495 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cl19123 226900004496 Protein of unknown function (DUF327); Region: DUF327; pfam03885 226900004497 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 226900004498 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 226900004499 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 226900004500 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004501 flagellar capping protein; Validated; Region: fliD; PRK06798 226900004502 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 226900004503 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 226900004504 Flagellar protein FliS; Region: FliS; cl00654 226900004505 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 226900004506 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 226900004507 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 226900004508 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 226900004509 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 226900004510 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 226900004511 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 226900004512 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 226900004513 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 226900004514 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 226900004515 FliG N-terminal domain; Region: FliG_N; pfam14842 226900004516 FliG middle domain; Region: FliG_M; pfam14841 226900004517 FliG C-terminal domain; Region: FliG_C; pfam01706 226900004518 flagellar assembly protein H; Validated; Region: fliH; PRK06800 226900004519 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 226900004520 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226900004521 Walker A motif; other site 226900004522 ATP binding site [chemical binding]; other site 226900004523 Walker B motif; other site 226900004524 similar to hypothetical protein 226900004525 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 226900004526 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 226900004527 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 226900004528 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 226900004529 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 226900004530 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 226900004531 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 226900004532 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 226900004533 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 226900004534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004535 active site 226900004536 phosphorylation site [posttranslational modification] 226900004537 intermolecular recognition site; other site 226900004538 dimerization interface [polypeptide binding]; other site 226900004539 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 226900004540 flagellin; Provisional; Region: PRK12807 226900004541 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004542 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 226900004543 flagellin; Provisional; Region: PRK12807 226900004544 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004545 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 226900004546 flagellin; Provisional; Region: PRK12807 226900004547 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004548 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 226900004549 flagellin; Provisional; Region: PRK12807 226900004550 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 226900004551 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 226900004552 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 226900004553 Protein of Unknown function (DUF1690); Region: DUF1690; pfam07956 226900004554 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 226900004555 N-acetyl-D-glucosamine binding site [chemical binding]; other site 226900004556 catalytic residue [active] 226900004557 flagellar motor switch protein; Validated; Region: PRK06789 226900004558 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 226900004559 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 226900004560 flagellar motor switch protein; Validated; Region: PRK06788 226900004561 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 226900004562 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 226900004563 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 226900004564 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 226900004565 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 226900004566 similar to Flagellar biosynthesis protein flhA 226900004567 similar to Flagellar biosynthesis protein flhF 226900004568 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 226900004569 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 226900004570 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 226900004571 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 226900004572 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 226900004573 Predicted transcriptional regulators [Transcription]; Region: COG1378 226900004574 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 226900004575 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 226900004576 C-terminal domain interface [polypeptide binding]; other site 226900004577 sugar binding site [chemical binding]; other site 226900004578 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 226900004579 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 226900004580 Dienelactone hydrolase family; Region: DLH; pfam01738 226900004581 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 226900004582 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 226900004583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900004584 non-specific DNA binding site [nucleotide binding]; other site 226900004585 salt bridge; other site 226900004586 sequence-specific DNA binding site [nucleotide binding]; other site 226900004587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004588 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900004589 putative substrate translocation pore; other site 226900004590 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 226900004591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900004592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900004593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900004594 dimerization interface [polypeptide binding]; other site 226900004595 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 226900004596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900004597 Walker A/P-loop; other site 226900004598 ATP binding site [chemical binding]; other site 226900004599 Q-loop/lid; other site 226900004600 ABC transporter signature motif; other site 226900004601 Walker B; other site 226900004602 D-loop; other site 226900004603 H-loop/switch region; other site 226900004604 TOBE domain; Region: TOBE_2; pfam08402 226900004605 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 226900004606 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 226900004607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900004608 dimer interface [polypeptide binding]; other site 226900004609 conserved gate region; other site 226900004610 putative PBP binding loops; other site 226900004611 ABC-ATPase subunit interface; other site 226900004612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900004613 dimer interface [polypeptide binding]; other site 226900004614 conserved gate region; other site 226900004615 putative PBP binding loops; other site 226900004616 ABC-ATPase subunit interface; other site 226900004617 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 226900004618 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 226900004619 Beta-Casp domain; Region: Beta-Casp; smart01027 226900004620 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 226900004621 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 226900004622 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900004623 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900004624 catalytic core [active] 226900004625 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900004626 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900004627 hypothetical protein; Provisional; Region: PRK09272 226900004628 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900004629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 226900004630 dimerization interface [polypeptide binding]; other site 226900004631 putative Zn2+ binding site [ion binding]; other site 226900004632 putative DNA binding site [nucleotide binding]; other site 226900004633 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 226900004634 active site 226900004635 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 226900004636 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 226900004637 active site 226900004638 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 226900004639 dimer interface [polypeptide binding]; other site 226900004640 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 226900004641 Ligand Binding Site [chemical binding]; other site 226900004642 Molecular Tunnel; other site 226900004643 RNA polymerase factor sigma-70; Validated; Region: PRK06811 226900004644 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900004645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900004646 DNA binding residues [nucleotide binding] 226900004647 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 226900004648 VPS10 domain; Region: VPS10; smart00602 226900004649 VPS10 domain; Region: VPS10; smart00602 226900004650 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 226900004651 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 226900004652 Transcriptional regulators [Transcription]; Region: GntR; COG1802 226900004653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900004654 DNA-binding site [nucleotide binding]; DNA binding site 226900004655 FCD domain; Region: FCD; pfam07729 226900004656 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900004657 EamA-like transporter family; Region: EamA; pfam00892 226900004658 EamA-like transporter family; Region: EamA; pfam00892 226900004659 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 226900004660 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 226900004661 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 226900004662 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 226900004663 Predicted permeases [General function prediction only]; Region: COG0701 226900004664 TIGR03943 family protein; Region: TIGR03943 226900004665 Methyltransferase domain; Region: Methyltransf_24; pfam13578 226900004666 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 226900004667 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226900004668 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 226900004669 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900004670 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 226900004671 DNA binding residues [nucleotide binding] 226900004672 putative dimer interface [polypeptide binding]; other site 226900004673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900004674 short chain dehydrogenase; Region: adh_short; pfam00106 226900004675 NAD(P) binding site [chemical binding]; other site 226900004676 active site 226900004677 fumarate hydratase; Reviewed; Region: fumC; PRK00485 226900004678 Class II fumarases; Region: Fumarase_classII; cd01362 226900004679 active site 226900004680 tetramer interface [polypeptide binding]; other site 226900004681 Bacterial PH domain; Region: bPH_4; pfam06713 226900004682 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 226900004683 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 226900004684 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 226900004685 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 226900004686 active site pocket [active] 226900004687 oxyanion hole [active] 226900004688 catalytic triad [active] 226900004689 active site nucleophile [active] 226900004690 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 226900004691 Penicillinase repressor; Region: Penicillinase_R; pfam03965 226900004692 Peptidase family M48; Region: Peptidase_M48; cl12018 226900004693 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 226900004694 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226900004695 catalytic residues [active] 226900004696 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 226900004697 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 226900004698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900004699 non-specific DNA binding site [nucleotide binding]; other site 226900004700 salt bridge; other site 226900004701 sequence-specific DNA binding site [nucleotide binding]; other site 226900004702 Cupin domain; Region: Cupin_2; pfam07883 226900004703 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 226900004704 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900004705 catalytic residue [active] 226900004706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 226900004707 Protein of unknown function (DUF445); Region: DUF445; pfam04286 226900004708 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 226900004709 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 226900004710 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900004711 DNA binding residues [nucleotide binding] 226900004712 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900004713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004714 active site 226900004715 phosphorylation site [posttranslational modification] 226900004716 intermolecular recognition site; other site 226900004717 dimerization interface [polypeptide binding]; other site 226900004718 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900004719 DNA binding residues [nucleotide binding] 226900004720 dimerization interface [polypeptide binding]; other site 226900004721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900004722 Histidine kinase; Region: HisKA_3; pfam07730 226900004723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004724 Mg2+ binding site [ion binding]; other site 226900004725 G-X-G motif; other site 226900004726 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900004727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900004728 Walker A/P-loop; other site 226900004729 ATP binding site [chemical binding]; other site 226900004730 Q-loop/lid; other site 226900004731 ABC transporter signature motif; other site 226900004732 Walker B; other site 226900004733 D-loop; other site 226900004734 H-loop/switch region; other site 226900004735 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 226900004736 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 226900004737 Acyltransferase family; Region: Acyl_transf_3; cl19154 226900004738 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 226900004739 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 226900004740 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900004741 PLD-like domain; Region: PLDc_2; pfam13091 226900004742 putative active site [active] 226900004743 catalytic site [active] 226900004744 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900004745 PLD-like domain; Region: PLDc_2; pfam13091 226900004746 putative active site [active] 226900004747 catalytic site [active] 226900004748 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 226900004749 putative nucleotide binding site [chemical binding]; other site 226900004750 uridine monophosphate binding site [chemical binding]; other site 226900004751 homohexameric interface [polypeptide binding]; other site 226900004752 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 226900004753 aspartate ammonia-lyase; Provisional; Region: PRK14515 226900004754 Aspartase; Region: Aspartase; cd01357 226900004755 active sites [active] 226900004756 tetramer interface [polypeptide binding]; other site 226900004757 malate dehydrogenase; Provisional; Region: PRK13529 226900004758 Malic enzyme, N-terminal domain; Region: malic; pfam00390 226900004759 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 226900004760 NAD(P) binding site [chemical binding]; other site 226900004761 rod shape-determining protein MreC; Region: MreC; cl19252 226900004762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900004763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004764 ATP binding site [chemical binding]; other site 226900004765 Mg2+ binding site [ion binding]; other site 226900004766 G-X-G motif; other site 226900004767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900004768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004769 active site 226900004770 phosphorylation site [posttranslational modification] 226900004771 intermolecular recognition site; other site 226900004772 dimerization interface [polypeptide binding]; other site 226900004773 YcbB domain; Region: YcbB; pfam08664 226900004774 SWIM zinc finger; Region: SWIM; pfam04434 226900004775 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 226900004776 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 226900004777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900004778 ATP binding site [chemical binding]; other site 226900004779 putative Mg++ binding site [ion binding]; other site 226900004780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900004781 nucleotide binding region [chemical binding]; other site 226900004782 ATP-binding site [chemical binding]; other site 226900004783 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 226900004784 dimer interface [polypeptide binding]; other site 226900004785 active site 226900004786 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 226900004787 putative dimer interface [polypeptide binding]; other site 226900004788 aspartate kinase; Reviewed; Region: PRK06635 226900004789 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 226900004790 putative nucleotide binding site [chemical binding]; other site 226900004791 putative catalytic residues [active] 226900004792 putative Mg ion binding site [ion binding]; other site 226900004793 putative aspartate binding site [chemical binding]; other site 226900004794 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 226900004795 putative allosteric regulatory site; other site 226900004796 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 226900004797 DoxX-like family; Region: DoxX_3; pfam13781 226900004798 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 226900004799 YndJ-like protein; Region: YndJ; pfam14158 226900004800 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 226900004801 putative active site [active] 226900004802 nucleotide binding site [chemical binding]; other site 226900004803 nudix motif; other site 226900004804 putative metal binding site [ion binding]; other site 226900004805 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900004806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004807 putative substrate translocation pore; other site 226900004808 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 226900004809 Predicted transcriptional regulators [Transcription]; Region: COG1695 226900004810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004811 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900004812 putative substrate translocation pore; other site 226900004813 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226900004814 Resistant to P. syringae 6; Provisional; Region: PLN03210 226900004815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004816 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900004817 putative substrate translocation pore; other site 226900004818 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 226900004819 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 226900004820 dimer interface [polypeptide binding]; other site 226900004821 active site 226900004822 CoA binding pocket [chemical binding]; other site 226900004823 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 226900004824 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 226900004825 HflX GTPase family; Region: HflX; cd01878 226900004826 G1 box; other site 226900004827 GTP/Mg2+ binding site [chemical binding]; other site 226900004828 Switch I region; other site 226900004829 G2 box; other site 226900004830 G3 box; other site 226900004831 Switch II region; other site 226900004832 G4 box; other site 226900004833 G5 box; other site 226900004834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900004836 putative substrate translocation pore; other site 226900004837 cysteine synthase; Region: PLN02565 226900004838 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226900004839 dimer interface [polypeptide binding]; other site 226900004840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004841 catalytic residue [active] 226900004842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004843 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900004844 Coenzyme A binding pocket [chemical binding]; other site 226900004845 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 226900004846 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 226900004847 Na2 binding site [ion binding]; other site 226900004848 putative substrate binding site 1 [chemical binding]; other site 226900004849 Na binding site 1 [ion binding]; other site 226900004850 putative substrate binding site 2 [chemical binding]; other site 226900004851 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226900004852 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 226900004853 NodB motif; other site 226900004854 putative active site [active] 226900004855 putative catalytic site [active] 226900004856 putative Zn binding site [ion binding]; other site 226900004857 Mor transcription activator family; Region: Mor; cl02360 226900004858 Predicted membrane protein [Function unknown]; Region: COG2323 226900004859 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 226900004860 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 226900004861 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 226900004862 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 226900004863 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 226900004864 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 226900004865 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 226900004866 methionine sulfoxide reductase A; Provisional; Region: PRK14054 226900004867 similar to Short chain type dehydrogenase/reductase; EC_number 1.-.-.- 226900004868 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 226900004869 homodimer interface [polypeptide binding]; other site 226900004870 substrate-cofactor binding pocket; other site 226900004871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004872 catalytic residue [active] 226900004873 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 226900004874 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 226900004875 PYR/PP interface [polypeptide binding]; other site 226900004876 dimer interface [polypeptide binding]; other site 226900004877 TPP binding site [chemical binding]; other site 226900004878 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 226900004879 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 226900004880 TPP-binding site [chemical binding]; other site 226900004881 dimer interface [polypeptide binding]; other site 226900004882 similar to Acetolactate synthase large subunit; EC_number 4.1.3.18 226900004883 ketol-acid reductoisomerase; Provisional; Region: PRK13403 226900004884 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 226900004885 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 226900004886 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 226900004887 threonine dehydratase; Validated; Region: PRK08639 226900004888 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 226900004889 tetramer interface [polypeptide binding]; other site 226900004890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900004891 catalytic residue [active] 226900004892 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 226900004893 putative Ile/Val binding site [chemical binding]; other site 226900004894 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 226900004895 putative active site [active] 226900004896 putative metal binding site [ion binding]; other site 226900004897 Protein of unknown function (DUF554); Region: DUF554; pfam04474 226900004898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004899 Coenzyme A binding pocket [chemical binding]; other site 226900004900 drug efflux system protein MdtG; Provisional; Region: PRK09874 226900004901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900004902 putative substrate translocation pore; other site 226900004903 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 226900004904 putative active site [active] 226900004905 metal binding site [ion binding]; metal-binding site 226900004906 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 226900004907 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 226900004908 LytTr DNA-binding domain; Region: LytTR; pfam04397 226900004909 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226900004910 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 226900004911 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 226900004912 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 226900004913 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900004914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004915 Coenzyme A binding pocket [chemical binding]; other site 226900004916 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 226900004917 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 226900004918 active site 226900004919 putative substrate binding pocket [chemical binding]; other site 226900004920 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900004921 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900004922 peptide binding site [polypeptide binding]; other site 226900004923 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 226900004924 hypothetical protein; Provisional; Region: PRK06922 226900004925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900004926 S-adenosylmethionine binding site [chemical binding]; other site 226900004927 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 226900004928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900004929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004930 Coenzyme A binding pocket [chemical binding]; other site 226900004931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900004932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900004933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900004934 active site 226900004935 phosphorylation site [posttranslational modification] 226900004936 intermolecular recognition site; other site 226900004937 dimerization interface [polypeptide binding]; other site 226900004938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900004939 DNA binding site [nucleotide binding] 226900004940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900004941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900004942 dimerization interface [polypeptide binding]; other site 226900004943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900004944 dimer interface [polypeptide binding]; other site 226900004945 phosphorylation site [posttranslational modification] 226900004946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900004947 ATP binding site [chemical binding]; other site 226900004948 Mg2+ binding site [ion binding]; other site 226900004949 G-X-G motif; other site 226900004950 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 226900004951 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900004952 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226900004953 manganese transport protein MntH; Reviewed; Region: PRK00701 226900004954 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 226900004955 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 226900004956 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 226900004957 active site residue [active] 226900004958 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 226900004959 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 226900004960 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 226900004961 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 226900004962 Amino acid permease; Region: AA_permease_2; pfam13520 226900004963 K+ potassium transporter; Region: K_trans; cl15781 226900004964 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900004965 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900004966 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900004967 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 226900004968 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226900004969 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226900004970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900004971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900004972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900004973 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900004974 Coenzyme A binding pocket [chemical binding]; other site 226900004975 hypothetical protein; Provisional; Region: PRK12856 226900004976 CAAX protease self-immunity; Region: Abi; cl00558 226900004977 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900004978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900004979 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 226900004980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 226900004981 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 226900004982 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 226900004983 intersubunit interface [polypeptide binding]; other site 226900004984 active site 226900004985 catalytic residue [active] 226900004986 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900004987 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900004988 Nucleoside recognition; Region: Gate; pfam07670 226900004989 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900004990 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 226900004991 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 226900004992 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 226900004993 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 226900004994 cytidine deaminase, homotetrameric; Region: cyt_deam_tetra; TIGR01354 226900004995 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 226900004996 active site 226900004997 catalytic motif [active] 226900004998 Zn binding site [ion binding]; other site 226900004999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900005000 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900005001 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900005002 Herpesvirus BLRF2 protein; Region: Herpes_BLRF2; pfam05812 226900005003 putative transposase OrfB; Reviewed; Region: PHA02517 226900005004 HTH-like domain; Region: HTH_21; pfam13276 226900005005 Integrase core domain; Region: rve; pfam00665 226900005006 Integrase core domain; Region: rve_2; pfam13333 226900005007 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 226900005008 hypothetical protein; Provisional; Region: PRK01631 226900005009 proline aminopeptidase P II; Provisional; Region: PRK10879 226900005010 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 226900005011 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 226900005012 active site 226900005013 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 226900005014 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 226900005015 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 226900005016 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 226900005017 The first cupredoxin domain of CumA like multicopper oxidase; Region: CuRO_1_CumA_like; cd13861 226900005018 putative Domain 2 interface [polypeptide binding]; other site 226900005019 putative Domain 3 interface [polypeptide binding]; other site 226900005020 trinuclear Cu binding site [ion binding]; other site 226900005021 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 226900005022 trimer interface [polypeptide binding]; other site 226900005023 The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202 226900005024 trimer interface [polypeptide binding]; other site 226900005025 trinuclear Cu binding site [ion binding]; other site 226900005026 DNA topoisomerase III; Provisional; Region: PRK07726 226900005027 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 226900005028 active site 226900005029 putative interdomain interaction site [polypeptide binding]; other site 226900005030 putative metal-binding site [ion binding]; other site 226900005031 putative nucleotide binding site [chemical binding]; other site 226900005032 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226900005033 domain I; other site 226900005034 DNA binding groove [nucleotide binding] 226900005035 phosphate binding site [ion binding]; other site 226900005036 domain II; other site 226900005037 domain III; other site 226900005038 nucleotide binding site [chemical binding]; other site 226900005039 catalytic site [active] 226900005040 domain IV; other site 226900005041 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 226900005042 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 226900005043 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 226900005044 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 226900005045 azoreductase; Provisional; Region: PRK13555 226900005046 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 226900005047 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 226900005048 dimer interface [polypeptide binding]; other site 226900005049 substrate binding site [chemical binding]; other site 226900005050 metal binding site [ion binding]; metal-binding site 226900005051 CopC domain; Region: CopC; pfam04234 226900005052 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 226900005053 YtkA-like; Region: YtkA; pfam13115 226900005054 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 226900005055 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900005056 EamA-like transporter family; Region: EamA; pfam00892 226900005057 EamA-like transporter family; Region: EamA; pfam00892 226900005058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900005059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900005060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900005061 dimerization interface [polypeptide binding]; other site 226900005062 Rrf2 family protein; Region: rrf2_super; TIGR00738 226900005063 Transcriptional regulator; Region: Rrf2; pfam02082 226900005064 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 226900005065 catalytic residues [active] 226900005066 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 226900005067 dimer interface [polypeptide binding]; other site 226900005068 FMN binding site [chemical binding]; other site 226900005069 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 226900005070 Bacteriophage phBC6A51; identified by comparison with Bacillus anthracis; and Bacillus thuringiensis 226900005071 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900005072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900005073 non-specific DNA binding site [nucleotide binding]; other site 226900005074 salt bridge; other site 226900005075 sequence-specific DNA binding site [nucleotide binding]; other site 226900005076 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900005077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900005078 non-specific DNA binding site [nucleotide binding]; other site 226900005079 salt bridge; other site 226900005080 sequence-specific DNA binding site [nucleotide binding]; other site 226900005081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900005082 non-specific DNA binding site [nucleotide binding]; other site 226900005083 salt bridge; other site 226900005084 sequence-specific DNA binding site [nucleotide binding]; other site 226900005085 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 226900005086 AAA domain; Region: AAA_23; pfam13476 226900005087 Walker A/P-loop; other site 226900005088 ATP binding site [chemical binding]; other site 226900005089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900005090 Walker B; other site 226900005091 D-loop; other site 226900005092 H-loop/switch region; other site 226900005093 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 226900005094 active site 226900005095 metal binding site [ion binding]; metal-binding site 226900005096 DNA binding site [nucleotide binding] 226900005097 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 226900005098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900005099 ATP binding site [chemical binding]; other site 226900005100 putative Mg++ binding site [ion binding]; other site 226900005101 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 226900005102 nucleotide binding site [chemical binding]; other site 226900005103 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 226900005104 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 226900005105 active site 226900005106 substrate binding site [chemical binding]; other site 226900005107 catalytic site [active] 226900005108 DNA polymerase A type from plastids of higher plants possibly involve in DNA replication or in the repair of errors occurring during replication; Region: DNA_pol_A_plastid_like; cd08640 226900005109 active site 226900005110 DNA binding site [nucleotide binding] 226900005111 catalytic site [active] 226900005112 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 226900005113 active site 226900005114 homodimer interface [polypeptide binding]; other site 226900005115 metal binding site [ion binding]; metal-binding site 226900005116 YopX protein; Region: YopX; cl09859 226900005117 Entomopoxvirus spheroidin protein; Region: Spheroidin; pfam05541 226900005118 HNH endonuclease; Region: HNH_3; pfam13392 226900005119 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 226900005120 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 226900005121 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 226900005122 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 226900005123 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531 226900005124 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226900005125 Head fiber protein; Region: Phage_head_fibr; pfam11133 226900005126 similar to Phage protein 226900005127 phage major tail protein, TP901-1 family; Region: phgtail_TP901_1; TIGR02126 226900005128 Phage protein; Region: DUF3647; pfam12363 226900005129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226900005130 putative minor structural protein; Region: PHA01351 226900005131 Phage-related protein [Function unknown]; Region: COG5412 226900005132 similar to Phage protein 226900005133 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 226900005134 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 226900005135 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 226900005136 Haemolysin XhlA; Region: XhlA; pfam10779 226900005137 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900005138 amidase catalytic site [active] 226900005139 Zn binding residues [ion binding]; other site 226900005140 substrate binding site [chemical binding]; other site 226900005141 Bacterial SH3 domain; Region: SH3_3; cl17532 226900005142 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 226900005143 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226900005144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900005145 non-specific DNA binding site [nucleotide binding]; other site 226900005146 salt bridge; other site 226900005147 sequence-specific DNA binding site [nucleotide binding]; other site 226900005148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900005149 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900005150 non-specific DNA binding site [nucleotide binding]; other site 226900005151 salt bridge; other site 226900005152 sequence-specific DNA binding site [nucleotide binding]; other site 226900005153 similar to DNA segregation ATPase FtsK/SpoIIIE and related proteins 226900005154 Replication-relaxation; Region: Replic_Relax; pfam13814 226900005155 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226900005156 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 226900005157 catalytic residues [active] 226900005158 catalytic nucleophile [active] 226900005159 Recombinase; Region: Recombinase; pfam07508 226900005160 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 226900005161 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226900005162 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 226900005163 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 226900005164 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900005165 NAD binding site [chemical binding]; other site 226900005166 dimer interface [polypeptide binding]; other site 226900005167 substrate binding site [chemical binding]; other site 226900005168 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 226900005169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226900005170 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 226900005171 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 226900005172 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 226900005173 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 226900005174 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 226900005175 putative ligand binding site [chemical binding]; other site 226900005176 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 226900005177 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 226900005178 Walker A/P-loop; other site 226900005179 ATP binding site [chemical binding]; other site 226900005180 Q-loop/lid; other site 226900005181 ABC transporter signature motif; other site 226900005182 Walker B; other site 226900005183 D-loop; other site 226900005184 H-loop/switch region; other site 226900005185 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 226900005186 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 226900005187 Walker A/P-loop; other site 226900005188 ATP binding site [chemical binding]; other site 226900005189 Q-loop/lid; other site 226900005190 ABC transporter signature motif; other site 226900005191 Walker B; other site 226900005192 D-loop; other site 226900005193 H-loop/switch region; other site 226900005194 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 226900005195 TM-ABC transporter signature motif; other site 226900005196 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 226900005197 TM-ABC transporter signature motif; other site 226900005198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900005199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900005200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900005201 dimerization interface [polypeptide binding]; other site 226900005202 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 226900005203 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900005204 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900005205 putative Zn2+ binding site [ion binding]; other site 226900005206 putative DNA binding site [nucleotide binding]; other site 226900005207 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 226900005208 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 226900005209 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 226900005210 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 226900005211 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 226900005212 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900005213 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 226900005214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900005215 Walker A/P-loop; other site 226900005216 ATP binding site [chemical binding]; other site 226900005217 Q-loop/lid; other site 226900005218 ABC transporter signature motif; other site 226900005219 Walker B; other site 226900005220 D-loop; other site 226900005221 H-loop/switch region; other site 226900005222 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 226900005223 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900005224 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 226900005225 Walker A/P-loop; other site 226900005226 ATP binding site [chemical binding]; other site 226900005227 Q-loop/lid; other site 226900005228 ABC transporter signature motif; other site 226900005229 Walker B; other site 226900005230 D-loop; other site 226900005231 H-loop/switch region; other site 226900005232 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900005233 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 226900005234 active site 226900005235 YcaO-like family; Region: YcaO; cl19253 226900005236 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900005237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900005238 active site 226900005239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900005240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 226900005241 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 226900005242 inhibitor-cofactor binding pocket; inhibition site 226900005243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005244 catalytic residue [active] 226900005245 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226900005246 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 226900005247 trimer interface [polypeptide binding]; other site 226900005248 active site 226900005249 substrate binding site [chemical binding]; other site 226900005250 CoA binding site [chemical binding]; other site 226900005251 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 226900005252 EamA-like transporter family; Region: EamA; pfam00892 226900005253 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 226900005254 putative dimer interface [polypeptide binding]; other site 226900005255 catalytic triad [active] 226900005256 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900005257 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900005258 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 226900005259 dimer interface [polypeptide binding]; other site 226900005260 FMN binding site [chemical binding]; other site 226900005261 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900005262 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900005263 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900005264 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 226900005265 NlpC/P60 family; Region: NLPC_P60; pfam00877 226900005266 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900005267 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900005268 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900005269 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900005270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900005271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900005272 Walker A/P-loop; other site 226900005273 ATP binding site [chemical binding]; other site 226900005274 Q-loop/lid; other site 226900005275 ABC transporter signature motif; other site 226900005276 Walker B; other site 226900005277 D-loop; other site 226900005278 H-loop/switch region; other site 226900005279 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900005280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900005281 active site 226900005282 phosphorylation site [posttranslational modification] 226900005283 intermolecular recognition site; other site 226900005284 dimerization interface [polypeptide binding]; other site 226900005285 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900005286 DNA binding site [nucleotide binding] 226900005287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900005288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900005289 dimerization interface [polypeptide binding]; other site 226900005290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900005291 dimer interface [polypeptide binding]; other site 226900005292 phosphorylation site [posttranslational modification] 226900005293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900005294 ATP binding site [chemical binding]; other site 226900005295 Mg2+ binding site [ion binding]; other site 226900005296 G-X-G motif; other site 226900005297 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 226900005298 classical (c) SDRs; Region: SDR_c; cd05233 226900005299 NAD(P) binding site [chemical binding]; other site 226900005300 active site 226900005301 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 226900005302 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226900005303 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 226900005304 NodB motif; other site 226900005305 active site 226900005306 catalytic site [active] 226900005307 metal binding site [ion binding]; metal-binding site 226900005308 SdpI/YhfL protein family; Region: SdpI; pfam13630 226900005309 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 226900005310 nudix motif; other site 226900005311 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 226900005312 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 226900005313 homoserine dehydrogenase; Provisional; Region: PRK06349 226900005314 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 226900005315 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 226900005316 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 226900005317 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 226900005318 cysteine synthase; Region: PLN02565 226900005319 homodimer interface [polypeptide binding]; other site 226900005320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005321 catalytic residue [active] 226900005322 homoserine kinase; Provisional; Region: PRK01212 226900005323 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 226900005324 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 226900005325 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 226900005326 Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308 226900005327 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 226900005328 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900005329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900005330 active site 226900005331 phosphorylation site [posttranslational modification] 226900005332 intermolecular recognition site; other site 226900005333 dimerization interface [polypeptide binding]; other site 226900005334 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900005335 DNA binding site [nucleotide binding] 226900005336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900005337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900005338 dimerization interface [polypeptide binding]; other site 226900005339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900005340 dimer interface [polypeptide binding]; other site 226900005341 phosphorylation site [posttranslational modification] 226900005342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900005343 ATP binding site [chemical binding]; other site 226900005344 Mg2+ binding site [ion binding]; other site 226900005345 G-X-G motif; other site 226900005346 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226900005347 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 226900005348 NodB motif; other site 226900005349 active site 226900005350 catalytic site [active] 226900005351 Zn binding site [ion binding]; other site 226900005352 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 226900005353 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 226900005354 MgtC family; Region: MgtC; pfam02308 226900005355 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900005356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005357 Coenzyme A binding pocket [chemical binding]; other site 226900005358 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 226900005359 IucA / IucC family; Region: IucA_IucC; pfam04183 226900005360 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 226900005361 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 226900005362 IucA / IucC family; Region: IucA_IucC; pfam04183 226900005363 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 226900005364 acyl-CoA synthetase; Validated; Region: PRK08308 226900005365 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226900005366 acyl-activating enzyme (AAE) consensus motif; other site 226900005367 AMP binding site [chemical binding]; other site 226900005368 active site 226900005369 CoA binding site [chemical binding]; other site 226900005370 acyl carrier protein; Provisional; Region: PRK07639 226900005371 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 226900005372 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 226900005373 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900005374 similar to Tetracycline resistance protein 226900005375 Lysine efflux permease [General function prediction only]; Region: COG1279 226900005376 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900005377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900005378 DNA-binding site [nucleotide binding]; DNA binding site 226900005379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900005380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005381 homodimer interface [polypeptide binding]; other site 226900005382 catalytic residue [active] 226900005383 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 226900005384 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 226900005385 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 226900005386 active site 226900005387 nucleophile elbow; other site 226900005388 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 226900005389 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 226900005390 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 226900005391 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 226900005392 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 226900005393 nudix motif; other site 226900005394 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 226900005395 homodimer interface [polypeptide binding]; other site 226900005396 NAD binding pocket [chemical binding]; other site 226900005397 ATP binding pocket [chemical binding]; other site 226900005398 Mg binding site [ion binding]; other site 226900005399 active-site loop [active] 226900005400 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900005401 FtsX-like permease family; Region: FtsX; pfam02687 226900005402 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 226900005403 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 226900005404 Subtilase family; Region: Peptidase_S8; pfam00082 226900005405 active site 226900005406 catalytic residues [active] 226900005407 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900005408 dimerization interface [polypeptide binding]; other site 226900005409 putative DNA binding site [nucleotide binding]; other site 226900005410 putative Zn2+ binding site [ion binding]; other site 226900005411 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 226900005412 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900005413 active site 226900005414 catalytic tetrad [active] 226900005415 similar to Chloramphenicol resistance protein 226900005416 Protein of unknown function (DUF805); Region: DUF805; pfam05656 226900005417 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 226900005418 Protein of unknown function (DUF664); Region: DUF664; pfam04978 226900005419 GTPase RsgA; Reviewed; Region: PRK01889 226900005420 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226900005421 RNA binding site [nucleotide binding]; other site 226900005422 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 226900005423 GTPase/Zn-binding domain interface [polypeptide binding]; other site 226900005424 GTP/Mg2+ binding site [chemical binding]; other site 226900005425 G4 box; other site 226900005426 G5 box; other site 226900005427 G1 box; other site 226900005428 Switch I region; other site 226900005429 G2 box; other site 226900005430 G3 box; other site 226900005431 Switch II region; other site 226900005432 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 226900005433 Cache domain; Region: Cache_1; pfam02743 226900005434 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900005435 dimerization interface [polypeptide binding]; other site 226900005436 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900005437 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 226900005438 dimer interface [polypeptide binding]; other site 226900005439 putative CheW interface [polypeptide binding]; other site 226900005440 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 226900005441 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 226900005442 Ferritin-like domain; Region: Ferritin; pfam00210 226900005443 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 226900005444 dimerization interface [polypeptide binding]; other site 226900005445 DPS ferroxidase diiron center [ion binding]; other site 226900005446 ion pore; other site 226900005447 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 226900005448 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226900005449 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226900005450 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 226900005451 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 226900005452 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 226900005453 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 226900005454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226900005455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900005456 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900005457 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900005458 active site 226900005459 catalytic tetrad [active] 226900005460 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 226900005461 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 226900005462 P-loop, Walker A motif; other site 226900005463 Base recognition motif; other site 226900005464 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 226900005465 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900005466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005467 Coenzyme A binding pocket [chemical binding]; other site 226900005468 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 226900005469 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 226900005470 metal binding site [ion binding]; metal-binding site 226900005471 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 226900005472 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900005473 NAD binding site [chemical binding]; other site 226900005474 active site 226900005475 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 226900005476 active site 226900005477 FMN binding site [chemical binding]; other site 226900005478 substrate binding site [chemical binding]; other site 226900005479 homotetramer interface [polypeptide binding]; other site 226900005480 catalytic residue [active] 226900005481 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 226900005482 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 226900005483 DNA binding site [nucleotide binding] 226900005484 active site 226900005485 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 226900005486 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900005487 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900005488 peptide binding site [polypeptide binding]; other site 226900005489 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 226900005490 active site 226900005491 metal binding site [ion binding]; metal-binding site 226900005492 short chain dehydrogenase; Provisional; Region: PRK08309 226900005493 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900005494 catalytic core [active] 226900005495 CotH protein; Region: CotH; cl19892 226900005496 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 226900005497 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 226900005498 nudix motif; other site 226900005499 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 226900005500 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226900005501 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 226900005502 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 226900005503 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 226900005504 Cl binding site [ion binding]; other site 226900005505 oligomer interface [polypeptide binding]; other site 226900005506 Predicted permeases [General function prediction only]; Region: COG0701 226900005507 Predicted membrane protein [Function unknown]; Region: COG3689 226900005508 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 226900005509 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900005510 PLD-like domain; Region: PLDc_2; pfam13091 226900005511 putative active site [active] 226900005512 catalytic site [active] 226900005513 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900005514 PLD-like domain; Region: PLDc_2; pfam13091 226900005515 putative active site [active] 226900005516 catalytic site [active] 226900005517 Coat F domain; Region: Coat_F; pfam07875 226900005518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900005519 NAD(P) binding site [chemical binding]; other site 226900005520 active site 226900005521 Protein of unknown function (DUF456); Region: DUF456; pfam04306 226900005522 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226900005523 Domain of unknown function DUF21; Region: DUF21; pfam01595 226900005524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226900005525 Transporter associated domain; Region: CorC_HlyC; smart01091 226900005526 5'-3' exonuclease [DNA replication, recombination, and repair / Cell division and chromosome partitioning / Translation]; Region: XRN1; COG5049 226900005527 FOG: CBS domain [General function prediction only]; Region: COG0517 226900005528 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 226900005529 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 226900005530 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 226900005531 dimer interface [polypeptide binding]; other site 226900005532 putative tRNA-binding site [nucleotide binding]; other site 226900005533 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 226900005534 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 226900005535 stage II sporulation protein P; Region: spore_II_P; TIGR02867 226900005536 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900005537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005538 Coenzyme A binding pocket [chemical binding]; other site 226900005539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900005540 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 226900005541 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 226900005542 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 226900005543 nudix motif; other site 226900005544 amidase; Provisional; Region: PRK06828 226900005545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900005546 putative substrate translocation pore; other site 226900005547 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900005548 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 226900005549 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 226900005550 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 226900005551 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 226900005552 stage II sporulation protein P; Region: spore_II_P; TIGR02867 226900005553 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900005554 catalytic core [active] 226900005555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900005556 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900005557 active site 226900005558 motif I; other site 226900005559 motif II; other site 226900005560 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900005561 multidrug resistance protein MdtH; Provisional; Region: PRK11646 226900005562 DinB superfamily; Region: DinB_2; pfam12867 226900005563 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 226900005564 alanine racemase; Reviewed; Region: alr; PRK00053 226900005565 active site 226900005566 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900005567 dimer interface [polypeptide binding]; other site 226900005568 substrate binding site [chemical binding]; other site 226900005569 catalytic residues [active] 226900005570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005571 Coenzyme A binding pocket [chemical binding]; other site 226900005572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005573 Coenzyme A binding pocket [chemical binding]; other site 226900005574 Phosphotransferase enzyme family; Region: APH; pfam01636 226900005575 active site 226900005576 ATP binding site [chemical binding]; other site 226900005577 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 226900005578 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 226900005579 glycosyltransferase, MGT family; Region: MGT; TIGR01426 226900005580 active site 226900005581 TDP-binding site; other site 226900005582 acceptor substrate-binding pocket; other site 226900005583 homodimer interface [polypeptide binding]; other site 226900005584 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900005585 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900005586 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900005587 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226900005588 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900005589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900005590 DNA-binding site [nucleotide binding]; DNA binding site 226900005591 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900005592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005593 homodimer interface [polypeptide binding]; other site 226900005594 catalytic residue [active] 226900005595 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900005596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005597 Coenzyme A binding pocket [chemical binding]; other site 226900005598 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 226900005599 active site 226900005600 metal binding site [ion binding]; metal-binding site 226900005601 Src Homology 3 domain superfamily; Region: SH3; cl17036 226900005602 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 226900005603 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900005604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005605 Coenzyme A binding pocket [chemical binding]; other site 226900005606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900005607 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 226900005608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900005609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005610 Coenzyme A binding pocket [chemical binding]; other site 226900005611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005612 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900005613 Coenzyme A binding pocket [chemical binding]; other site 226900005614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 226900005615 Predicted membrane protein [Function unknown]; Region: COG1511 226900005616 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 226900005617 Proline-rich; Region: Pro-rich; pfam15240 226900005618 CD99 antigen like protein 2; Region: CD99L2; pfam12301 226900005619 Predicted membrane protein [Function unknown]; Region: COG1511 226900005620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900005621 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 226900005622 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 226900005623 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 226900005624 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 226900005625 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226900005626 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226900005627 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 226900005628 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 226900005629 nucleophilic elbow; other site 226900005630 catalytic triad; other site 226900005631 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 226900005632 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 226900005633 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226900005634 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 226900005635 nucleophilic elbow; other site 226900005636 catalytic triad; other site 226900005637 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 226900005638 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 226900005639 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 226900005640 Predicted acetyltransferase [General function prediction only]; Region: COG3393 226900005641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900005643 Coenzyme A binding pocket [chemical binding]; other site 226900005644 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 226900005645 Winged helix DNA-binding domain; Region: HTH_42; cl19833 226900005646 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900005647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900005648 S-adenosylmethionine binding site [chemical binding]; other site 226900005649 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 226900005650 Potassium binding sites [ion binding]; other site 226900005651 Cesium cation binding sites [ion binding]; other site 226900005652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 226900005653 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900005654 ATP binding site [chemical binding]; other site 226900005655 putative Mg++ binding site [ion binding]; other site 226900005656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900005657 nucleotide binding region [chemical binding]; other site 226900005658 ATP-binding site [chemical binding]; other site 226900005659 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 226900005660 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 226900005661 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 226900005662 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900005663 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 226900005664 NADP binding site [chemical binding]; other site 226900005665 dimer interface [polypeptide binding]; other site 226900005666 RNA polymerase sigma factor; Provisional; Region: PRK12543 226900005667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900005668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900005669 DNA binding residues [nucleotide binding] 226900005670 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 226900005671 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 226900005672 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 226900005673 active site 226900005674 ATP binding site [chemical binding]; other site 226900005675 similar to Metal-dependent hydrolase; EC_number 3.-.-.- 226900005676 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 226900005677 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 226900005678 catalytic residues [active] 226900005679 dimer interface [polypeptide binding]; other site 226900005680 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 226900005681 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 226900005682 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 226900005683 similar to hypothetical Cytosolic Protein 226900005684 MoxR-like ATPases [General function prediction only]; Region: COG0714 226900005685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900005686 Walker A motif; other site 226900005687 ATP binding site [chemical binding]; other site 226900005688 Walker B motif; other site 226900005689 arginine finger; other site 226900005690 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 226900005691 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 226900005692 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 226900005693 [4Fe-4S] binding site [ion binding]; other site 226900005694 molybdopterin cofactor binding site [chemical binding]; other site 226900005695 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 226900005696 molybdopterin cofactor binding site; other site 226900005697 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 226900005698 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 226900005699 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 226900005700 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 226900005701 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 226900005702 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 226900005703 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900005704 ligand binding site [chemical binding]; other site 226900005705 flexible hinge region; other site 226900005706 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 226900005707 putative switch regulator; other site 226900005708 non-specific DNA interactions [nucleotide binding]; other site 226900005709 DNA binding site [nucleotide binding] 226900005710 sequence specific DNA binding site [nucleotide binding]; other site 226900005711 putative cAMP binding site [chemical binding]; other site 226900005712 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 226900005713 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900005714 FeS/SAM binding site; other site 226900005715 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 226900005716 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 226900005717 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 226900005718 ATP binding site [chemical binding]; other site 226900005719 substrate interface [chemical binding]; other site 226900005720 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 226900005721 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 226900005722 dimer interface [polypeptide binding]; other site 226900005723 putative functional site; other site 226900005724 putative MPT binding site; other site 226900005725 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 226900005726 MoaE homodimer interface [polypeptide binding]; other site 226900005727 MoaD interaction [polypeptide binding]; other site 226900005728 active site residues [active] 226900005729 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 226900005730 MoaE interaction surface [polypeptide binding]; other site 226900005731 MoeB interaction surface [polypeptide binding]; other site 226900005732 thiocarboxylated glycine; other site 226900005733 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 226900005734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900005735 putative substrate translocation pore; other site 226900005736 PspC domain; Region: PspC; cl00864 226900005737 Membrane transport protein; Region: Mem_trans; cl09117 226900005738 precorrin-2 dehydrogenase; Validated; Region: PRK06719 226900005739 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 226900005740 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 226900005741 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 226900005742 putative active site [active] 226900005743 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 226900005744 putative active site [active] 226900005745 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 226900005746 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 226900005747 active site 226900005748 SAM binding site [chemical binding]; other site 226900005749 homodimer interface [polypeptide binding]; other site 226900005750 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 226900005751 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 226900005752 [2Fe-2S] cluster binding site [ion binding]; other site 226900005753 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 226900005754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900005755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900005756 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 226900005757 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 226900005758 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 226900005759 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 226900005760 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 226900005761 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 226900005762 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 226900005763 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 226900005764 N-acetyltransferase; Region: Acetyltransf_2; cl00949 226900005765 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900005766 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 226900005767 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 226900005768 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 226900005769 metal binding site [ion binding]; metal-binding site 226900005770 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 226900005771 active site 226900005772 YolD-like protein; Region: YolD; pfam08863 226900005773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900005774 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 226900005775 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900005776 Zn2+ binding site [ion binding]; other site 226900005777 Mg2+ binding site [ion binding]; other site 226900005778 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900005779 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900005780 ABC transporter; Region: ABC_tran_2; pfam12848 226900005781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900005782 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 226900005783 Bax inhibitor 1 like; Region: BaxI_1; cl17691 226900005784 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 226900005785 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 226900005786 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226900005787 dimer interface [polypeptide binding]; other site 226900005788 ssDNA binding site [nucleotide binding]; other site 226900005789 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900005790 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 226900005791 Virulence factor; Region: Virulence_fact; pfam13769 226900005792 HEAT repeats; Region: HEAT_2; pfam13646 226900005793 HEAT repeats; Region: HEAT_2; pfam13646 226900005794 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 226900005795 Protein of unknown function, DUF393; Region: DUF393; pfam04134 226900005796 Disulphide isomerase; Region: Disulph_isomer; pfam06491 226900005797 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 226900005798 similar to Arginyl-tRNA synthetase; EC_number 6.1.1.19 226900005799 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 226900005800 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900005801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900005802 S-adenosylmethionine binding site [chemical binding]; other site 226900005803 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 226900005804 putative active site [active] 226900005805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005806 binding surface 226900005807 TPR motif; other site 226900005808 TPR repeat; Region: TPR_11; pfam13414 226900005809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005810 binding surface 226900005811 TPR motif; other site 226900005812 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226900005813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005814 binding surface 226900005815 TPR motif; other site 226900005816 TPR repeat; Region: TPR_11; pfam13414 226900005817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005818 binding surface 226900005819 TPR motif; other site 226900005820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005821 binding surface 226900005822 TPR motif; other site 226900005823 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226900005824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900005825 binding surface 226900005826 TPR motif; other site 226900005827 Tetratricopeptide repeat; Region: TPR_9; pfam13371 226900005828 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 226900005829 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 226900005830 active site 226900005831 HIGH motif; other site 226900005832 KMSKS motif; other site 226900005833 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 226900005834 tRNA binding surface [nucleotide binding]; other site 226900005835 anticodon binding site; other site 226900005836 Predicted membrane protein [Function unknown]; Region: COG2311 226900005837 Protein of unknown function (DUF418); Region: DUF418; cl12135 226900005838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900005839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900005840 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900005841 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900005842 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 226900005843 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 226900005844 Zn binding site [ion binding]; other site 226900005845 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 226900005846 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 226900005847 Dimer interface [polypeptide binding]; other site 226900005848 anticodon binding site; other site 226900005849 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 226900005850 homodimer interface [polypeptide binding]; other site 226900005851 motif 1; other site 226900005852 motif 2; other site 226900005853 active site 226900005854 motif 3; other site 226900005855 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 226900005856 Na2 binding site [ion binding]; other site 226900005857 putative substrate binding site 1 [chemical binding]; other site 226900005858 Na binding site 1 [ion binding]; other site 226900005859 putative substrate binding site 2 [chemical binding]; other site 226900005860 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 226900005861 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900005862 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 226900005863 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 226900005864 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226900005865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900005866 active site 226900005867 motif I; other site 226900005868 motif II; other site 226900005869 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 226900005870 fructuronate transporter; Provisional; Region: PRK10034; cl15264 226900005871 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 226900005872 putative active site [active] 226900005873 metal binding site [ion binding]; metal-binding site 226900005874 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 226900005875 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 226900005876 homodimer interaction site [polypeptide binding]; other site 226900005877 cofactor binding site; other site 226900005878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900005879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005880 Coenzyme A binding pocket [chemical binding]; other site 226900005881 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 226900005882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900005883 salt bridge; other site 226900005884 non-specific DNA binding site [nucleotide binding]; other site 226900005885 sequence-specific DNA binding site [nucleotide binding]; other site 226900005886 hypothetical protein; Validated; Region: PRK06769 226900005887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900005888 active site 226900005889 motif I; other site 226900005890 motif II; other site 226900005891 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900005892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900005893 Coenzyme A binding pocket [chemical binding]; other site 226900005894 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 226900005895 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900005896 Walker A/P-loop; other site 226900005897 ATP binding site [chemical binding]; other site 226900005898 Q-loop/lid; other site 226900005899 ABC transporter signature motif; other site 226900005900 Walker B; other site 226900005901 D-loop; other site 226900005902 H-loop/switch region; other site 226900005903 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 226900005904 YpjP-like protein; Region: YpjP; pfam14005 226900005905 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 226900005906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900005907 active site 226900005908 motif I; other site 226900005909 motif II; other site 226900005910 hypothetical protein; Provisional; Region: PRK06724 226900005911 active site 226900005912 metal binding site [ion binding]; metal-binding site 226900005913 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 226900005914 Phosphotransferase enzyme family; Region: APH; pfam01636 226900005915 active site 226900005916 substrate binding site [chemical binding]; other site 226900005917 ATP binding site [chemical binding]; other site 226900005918 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900005919 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 226900005920 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 226900005921 dimerization interface [polypeptide binding]; other site 226900005922 active site 226900005923 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 226900005924 folate binding site [chemical binding]; other site 226900005925 NADP+ binding site [chemical binding]; other site 226900005926 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 226900005927 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900005928 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 226900005929 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900005930 azoreductase; Reviewed; Region: PRK00170 226900005931 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 226900005932 putative acyl-acceptor binding pocket; other site 226900005933 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 226900005934 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 226900005935 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 226900005936 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 226900005937 EDD domain protein, DegV family; Region: DegV; TIGR00762 226900005938 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 226900005939 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 226900005940 Cu(I) binding site [ion binding]; other site 226900005941 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 226900005942 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 226900005943 putative dimer interface [polypeptide binding]; other site 226900005944 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 226900005945 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 226900005946 active site 226900005947 dimer interface [polypeptide binding]; other site 226900005948 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 226900005949 Ligand Binding Site [chemical binding]; other site 226900005950 Molecular Tunnel; other site 226900005951 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900005952 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 226900005953 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900005954 active site 226900005955 metal binding site [ion binding]; metal-binding site 226900005956 Bacterial SH3 domain homologues; Region: SH3b; smart00287 226900005957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 226900005958 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900005959 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 226900005960 siderophore binding site; other site 226900005961 D-amino acid aminotransferase; Reviewed; Region: PRK06680 226900005962 homodimer interface [polypeptide binding]; other site 226900005963 substrate-cofactor binding pocket; other site 226900005964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900005965 catalytic residue [active] 226900005966 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 226900005967 FMN binding site [chemical binding]; other site 226900005968 dimer interface [polypeptide binding]; other site 226900005969 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 226900005970 catalytic triad [active] 226900005971 conserved cis-peptide bond; other site 226900005972 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 226900005973 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 226900005974 putative dimer interface [polypeptide binding]; other site 226900005975 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 226900005976 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226900005977 GAF domain; Region: GAF_2; pfam13185 226900005978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900005979 Histidine kinase; Region: HisKA_3; pfam07730 226900005980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900005981 ATP binding site [chemical binding]; other site 226900005982 Mg2+ binding site [ion binding]; other site 226900005983 G-X-G motif; other site 226900005984 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900005985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900005986 active site 226900005987 phosphorylation site [posttranslational modification] 226900005988 intermolecular recognition site; other site 226900005989 dimerization interface [polypeptide binding]; other site 226900005990 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900005991 DNA binding residues [nucleotide binding] 226900005992 dimerization interface [polypeptide binding]; other site 226900005993 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 226900005994 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 226900005995 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 226900005996 putative active site [active] 226900005997 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 226900005998 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 226900005999 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 226900006000 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 226900006001 NAD binding site [chemical binding]; other site 226900006002 substrate binding site [chemical binding]; other site 226900006003 catalytic Zn binding site [ion binding]; other site 226900006004 tetramer interface [polypeptide binding]; other site 226900006005 structural Zn binding site [ion binding]; other site 226900006006 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900006007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900006008 dimer interface [polypeptide binding]; other site 226900006009 conserved gate region; other site 226900006010 putative PBP binding loops; other site 226900006011 ABC-ATPase subunit interface; other site 226900006012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900006013 dimer interface [polypeptide binding]; other site 226900006014 conserved gate region; other site 226900006015 putative PBP binding loops; other site 226900006016 ABC-ATPase subunit interface; other site 226900006017 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 226900006018 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 226900006019 N- and C-terminal domain interface [polypeptide binding]; other site 226900006020 active site 226900006021 catalytic site [active] 226900006022 metal binding site [ion binding]; metal-binding site 226900006023 carbohydrate binding site [chemical binding]; other site 226900006024 ATP binding site [chemical binding]; other site 226900006025 GntP family permease; Region: GntP_permease; pfam02447 226900006026 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226900006027 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 226900006028 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 226900006029 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 226900006030 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 226900006031 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900006032 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900006033 active site 226900006034 Predicted flavoprotein [General function prediction only]; Region: COG0431 226900006035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006036 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900006037 putative substrate translocation pore; other site 226900006038 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900006039 putative active site [active] 226900006040 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 226900006041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900006042 Walker A/P-loop; other site 226900006043 ATP binding site [chemical binding]; other site 226900006044 Q-loop/lid; other site 226900006045 ABC transporter signature motif; other site 226900006046 Walker B; other site 226900006047 D-loop; other site 226900006048 H-loop/switch region; other site 226900006049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900006050 dimer interface [polypeptide binding]; other site 226900006051 conserved gate region; other site 226900006052 putative PBP binding loops; other site 226900006053 ABC-ATPase subunit interface; other site 226900006054 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 226900006055 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 226900006056 similar to 5-methylcytosine-specific restriction related enzyme 226900006057 Protein of unknown function (DUF524); Region: DUF524; pfam04411 226900006058 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 226900006059 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 226900006060 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226900006061 Domain of unknown function DUF21; Region: DUF21; pfam01595 226900006062 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226900006063 Transporter associated domain; Region: CorC_HlyC; smart01091 226900006064 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 226900006065 NAD(P) binding site [chemical binding]; other site 226900006066 catalytic residues [active] 226900006067 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 226900006068 similar to Sporulation kinase; EC_number 2.7.3.- 226900006069 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 226900006070 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 226900006071 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 226900006072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900006073 inhibitor-cofactor binding pocket; inhibition site 226900006074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900006075 catalytic residue [active] 226900006076 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 226900006077 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 226900006078 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 226900006079 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 226900006080 metal binding site [ion binding]; metal-binding site 226900006081 dimer interface [polypeptide binding]; other site 226900006082 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 226900006083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006084 Coenzyme A binding pocket [chemical binding]; other site 226900006085 PAS domain; Region: PAS; smart00091 226900006086 PAS fold; Region: PAS_4; pfam08448 226900006087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900006088 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 226900006089 Walker A motif; other site 226900006090 ATP binding site [chemical binding]; other site 226900006091 Walker B motif; other site 226900006092 arginine finger; other site 226900006093 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226900006094 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 226900006095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900006096 FeS/SAM binding site; other site 226900006097 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 226900006098 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 226900006099 toxin interface [polypeptide binding]; other site 226900006100 Zn binding site [ion binding]; other site 226900006101 hypothetical protein; Provisional; Region: PRK13672 226900006102 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 226900006103 YozD-like protein; Region: YozD; pfam14162 226900006104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 226900006105 Catalytic domain of Protein Kinases; Region: PKc; cd00180 226900006106 active site 226900006107 ATP binding site [chemical binding]; other site 226900006108 substrate binding site [chemical binding]; other site 226900006109 activation loop (A-loop); other site 226900006110 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; cl19290 226900006111 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 226900006112 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 226900006113 active site 226900006114 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 226900006115 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900006116 catalytic residues [active] 226900006117 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900006118 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900006119 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 226900006120 C1q domain; Region: C1q; cl17543 226900006121 C1q domain; Region: C1q; cl17543 226900006122 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 226900006123 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900006124 active site 226900006125 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 226900006126 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 226900006127 YolD-like protein; Region: YolD; pfam08863 226900006128 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900006129 short chain dehydrogenase; Region: adh_short; pfam00106 226900006130 classical (c) SDRs; Region: SDR_c; cd05233 226900006131 NAD(P) binding site [chemical binding]; other site 226900006132 active site 226900006133 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 226900006134 Transglycosylase; Region: Transgly; pfam00912 226900006135 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226900006136 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900006137 Nucleoporin FG repeat region; Region: Nucleoporin_FG; pfam13634 226900006138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900006140 putative substrate translocation pore; other site 226900006141 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 226900006142 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 226900006143 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 226900006144 dimer interface [polypeptide binding]; other site 226900006145 active site 226900006146 coenzyme A binding site [chemical binding]; other site 226900006147 citrylCoA binding site [chemical binding]; other site 226900006148 oxalacetate/citrate binding site [chemical binding]; other site 226900006149 catalytic triad [active] 226900006150 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 226900006151 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 226900006152 tetramer interface [polypeptide binding]; other site 226900006153 active site 226900006154 Mg2+/Mn2+ binding site [ion binding]; other site 226900006155 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 226900006156 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 226900006157 active site 226900006158 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 226900006159 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 226900006160 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 226900006161 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 226900006162 tetrameric interface [polypeptide binding]; other site 226900006163 NAD binding site [chemical binding]; other site 226900006164 catalytic residues [active] 226900006165 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 226900006166 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 226900006167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900006168 substrate binding site [chemical binding]; other site 226900006169 oxyanion hole (OAH) forming residues; other site 226900006170 trimer interface [polypeptide binding]; other site 226900006171 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 226900006172 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 226900006173 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 226900006174 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 226900006175 active site 226900006176 metal binding site [ion binding]; metal-binding site 226900006177 DNA binding site [nucleotide binding] 226900006178 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 226900006179 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 226900006180 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 226900006181 Walker A/P-loop; other site 226900006182 ATP binding site [chemical binding]; other site 226900006183 Q-loop/lid; other site 226900006184 Protein of unknown function (DUF342); Region: DUF342; cl19219 226900006185 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 226900006186 ABC transporter signature motif; other site 226900006187 Walker B; other site 226900006188 D-loop; other site 226900006189 H-loop/switch region; other site 226900006190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900006191 dimerization interface [polypeptide binding]; other site 226900006192 putative DNA binding site [nucleotide binding]; other site 226900006193 putative Zn2+ binding site [ion binding]; other site 226900006194 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 226900006195 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 226900006196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006197 putative substrate translocation pore; other site 226900006198 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 226900006199 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 226900006200 NAD(P) binding site [chemical binding]; other site 226900006201 active site 226900006202 isochorismate synthase DhbC; Validated; Region: PRK06923 226900006203 Integrin, beta chain; Region: Integrin_beta; cl17693 226900006204 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 226900006205 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 226900006206 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 226900006207 acyl-activating enzyme (AAE) consensus motif; other site 226900006208 active site 226900006209 AMP binding site [chemical binding]; other site 226900006210 substrate binding site [chemical binding]; other site 226900006211 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 226900006212 catalytic triad [active] 226900006213 conserved cis-peptide bond; other site 226900006214 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 226900006215 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900006216 MbtH-like protein; Region: MbtH; pfam03621 226900006217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900006219 putative substrate translocation pore; other site 226900006220 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 226900006221 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 226900006222 histone-like DNA-binding protein HU; Region: HU; cd13831 226900006223 dimer interface [polypeptide binding]; other site 226900006224 DNA binding site [nucleotide binding] 226900006225 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 226900006226 DinB family; Region: DinB; cl17821 226900006227 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 226900006228 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 226900006229 Subtilase family; Region: Peptidase_S8; pfam00082 226900006230 active site 226900006231 catalytic triad [active] 226900006232 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 226900006233 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900006234 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 226900006235 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900006236 RNA binding surface [nucleotide binding]; other site 226900006237 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 226900006238 probable active site [active] 226900006239 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 226900006240 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 226900006241 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 226900006242 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 226900006243 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 226900006244 active site 226900006245 dimer interface [polypeptide binding]; other site 226900006246 motif 1; other site 226900006247 motif 2; other site 226900006248 motif 3; other site 226900006249 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 226900006250 anticodon binding site; other site 226900006251 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900006252 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900006253 Walker A/P-loop; other site 226900006254 ATP binding site [chemical binding]; other site 226900006255 Q-loop/lid; other site 226900006256 ABC transporter signature motif; other site 226900006257 Walker B; other site 226900006258 D-loop; other site 226900006259 H-loop/switch region; other site 226900006260 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900006261 FtsX-like permease family; Region: FtsX; pfam02687 226900006262 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 226900006263 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 226900006264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 226900006265 pyruvate oxidase; Provisional; Region: PRK08611 226900006266 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 226900006267 PYR/PP interface [polypeptide binding]; other site 226900006268 dimer interface [polypeptide binding]; other site 226900006269 tetramer interface [polypeptide binding]; other site 226900006270 TPP binding site [chemical binding]; other site 226900006271 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 226900006272 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 226900006273 TPP-binding site [chemical binding]; other site 226900006274 ZIP Zinc transporter; Region: Zip; cl00437 226900006275 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900006276 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 226900006277 active site 226900006278 dimerization interface [polypeptide binding]; other site 226900006279 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 226900006280 Protein of unknown function, DUF606; Region: DUF606; pfam04657 226900006281 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 226900006282 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900006283 ligand binding site [chemical binding]; other site 226900006284 flexible hinge region; other site 226900006285 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 226900006286 Protein of unknown function, DUF606; Region: DUF606; pfam04657 226900006287 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 226900006288 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900006289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006290 Coenzyme A binding pocket [chemical binding]; other site 226900006291 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900006292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900006293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900006294 similar to Transporter, MMPL family 226900006295 putative transposase OrfB; Reviewed; Region: PHA02517 226900006296 HTH-like domain; Region: HTH_21; pfam13276 226900006297 Integrase core domain; Region: rve; pfam00665 226900006298 Integrase core domain; Region: rve_2; pfam13333 226900006299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900006300 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900006301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900006302 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900006303 Herpesvirus BLRF2 protein; Region: Herpes_BLRF2; pfam05812 226900006304 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 226900006305 Transposase IS200 like; Region: Y1_Tnp; pfam01797 226900006306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 226900006307 Probable transposase; Region: OrfB_IS605; pfam01385 226900006308 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900006309 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900006310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006311 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900006312 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900006313 Coenzyme A binding pocket [chemical binding]; other site 226900006314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900006315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006316 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 226900006317 Coenzyme A binding pocket [chemical binding]; other site 226900006318 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 226900006319 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 226900006320 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900006321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006322 Coenzyme A binding pocket [chemical binding]; other site 226900006323 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900006324 EamA-like transporter family; Region: EamA; pfam00892 226900006325 EamA-like transporter family; Region: EamA; pfam00892 226900006326 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 226900006327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900006328 non-specific DNA binding site [nucleotide binding]; other site 226900006329 salt bridge; other site 226900006330 sequence-specific DNA binding site [nucleotide binding]; other site 226900006331 Cupin domain; Region: Cupin_2; pfam07883 226900006332 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900006333 protoporphyrinogen oxidase; Provisional; Region: PRK12416 226900006334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226900006335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900006336 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900006337 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900006338 Cold-inducible protein YdjO; Region: YdjO; pfam14169 226900006339 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226900006340 DNA-binding site [nucleotide binding]; DNA binding site 226900006341 RNA-binding motif; other site 226900006342 CAAX protease self-immunity; Region: Abi; pfam02517 226900006343 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 226900006344 AAA domain; Region: AAA_18; pfam13238 226900006345 active site 226900006346 hypothetical protein; Provisional; Region: PRK06770 226900006347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900006348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900006349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900006350 dimerization interface [polypeptide binding]; other site 226900006351 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 226900006352 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 226900006353 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 226900006354 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 226900006355 active site 226900006356 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 226900006357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900006358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900006359 dimerization interface [polypeptide binding]; other site 226900006360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 226900006361 MOSC domain; Region: MOSC; pfam03473 226900006362 3-alpha domain; Region: 3-alpha; pfam03475 226900006363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006364 Coenzyme A binding pocket [chemical binding]; other site 226900006365 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 226900006366 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900006367 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900006368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900006369 Walker A/P-loop; other site 226900006370 ATP binding site [chemical binding]; other site 226900006371 Q-loop/lid; other site 226900006372 ABC transporter signature motif; other site 226900006373 Walker B; other site 226900006374 D-loop; other site 226900006375 H-loop/switch region; other site 226900006376 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900006377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900006378 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 226900006379 Walker A/P-loop; other site 226900006380 ATP binding site [chemical binding]; other site 226900006381 Q-loop/lid; other site 226900006382 ABC transporter signature motif; other site 226900006383 Walker B; other site 226900006384 D-loop; other site 226900006385 H-loop/switch region; other site 226900006386 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 226900006387 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 226900006388 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 226900006389 LysE type translocator; Region: LysE; cl00565 226900006390 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 226900006391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900006392 non-specific DNA binding site [nucleotide binding]; other site 226900006393 salt bridge; other site 226900006394 sequence-specific DNA binding site [nucleotide binding]; other site 226900006395 Cupin domain; Region: Cupin_2; pfam07883 226900006396 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900006397 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900006398 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900006399 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 226900006400 BclB C-terminal domain; Region: exospore_TM; TIGR03721 226900006401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226900006402 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 226900006403 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 226900006404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900006405 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226900006406 DNA binding residues [nucleotide binding] 226900006407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006408 S-adenosylmethionine binding site [chemical binding]; other site 226900006409 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 226900006410 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 226900006411 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 226900006412 Glycosyl hydrolase like GH101; Region: DUF187; pfam02638 226900006413 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226900006414 active site 226900006415 P-loop; other site 226900006416 phosphorylation site [posttranslational modification] 226900006417 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226900006418 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 226900006419 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 226900006420 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 226900006421 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 226900006422 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 226900006423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900006424 catalytic residue [active] 226900006425 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 226900006426 tetramer interface [polypeptide binding]; other site 226900006427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900006428 catalytic residue [active] 226900006429 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900006430 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900006431 putative DNA binding site [nucleotide binding]; other site 226900006432 putative Zn2+ binding site [ion binding]; other site 226900006433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006434 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900006435 putative substrate translocation pore; other site 226900006436 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 226900006437 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 226900006438 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226900006439 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900006440 ATP binding site [chemical binding]; other site 226900006441 Mg++ binding site [ion binding]; other site 226900006442 motif III; other site 226900006443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900006444 nucleotide binding region [chemical binding]; other site 226900006445 ATP-binding site [chemical binding]; other site 226900006446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900006447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900006448 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900006449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006450 putative substrate translocation pore; other site 226900006451 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 226900006452 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 226900006453 exosporium leader peptide; Region: exospor_lead; TIGR03720 226900006454 C1q domain; Region: C1q; cl17543 226900006455 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 226900006456 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 226900006457 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 226900006458 Int/Topo IB signature motif; other site 226900006459 M6 family metalloprotease domain; Region: M6dom_TIGR03296 226900006460 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 226900006461 sugar binding site [chemical binding]; other site 226900006462 Phage tail protein; Region: Sipho_tail; cl17486 226900006463 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 226900006464 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900006465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006466 S-adenosylmethionine binding site [chemical binding]; other site 226900006467 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 226900006468 dimer interface [polypeptide binding]; other site 226900006469 cell division protein FtsZ; Region: ftsZ; TIGR00065 226900006470 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 226900006471 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 226900006472 dimer interface [polypeptide binding]; other site 226900006473 PYR/PP interface [polypeptide binding]; other site 226900006474 TPP binding site [chemical binding]; other site 226900006475 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 226900006476 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 226900006477 TPP-binding site [chemical binding]; other site 226900006478 dimer interface [polypeptide binding]; other site 226900006479 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900006480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900006481 putative DNA binding site [nucleotide binding]; other site 226900006482 putative Zn2+ binding site [ion binding]; other site 226900006483 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900006484 catalytic core [active] 226900006485 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 226900006486 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 226900006487 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 226900006488 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 226900006489 metal binding site [ion binding]; metal-binding site 226900006490 dimer interface [polypeptide binding]; other site 226900006491 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 226900006492 putative active site [active] 226900006493 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 226900006494 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900006495 DNA binding residues [nucleotide binding] 226900006496 dimerization interface [polypeptide binding]; other site 226900006497 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900006498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900006499 non-specific DNA binding site [nucleotide binding]; other site 226900006500 salt bridge; other site 226900006501 sequence-specific DNA binding site [nucleotide binding]; other site 226900006502 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900006503 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 226900006504 hypothetical protein; Provisional; Region: PRK10621 226900006505 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226900006506 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 226900006507 trimer interface [polypeptide binding]; other site 226900006508 active site 226900006509 substrate binding site [chemical binding]; other site 226900006510 CoA binding site [chemical binding]; other site 226900006511 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900006512 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 226900006513 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 226900006514 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 226900006515 active site 226900006516 catalytic triad [active] 226900006517 oxyanion hole [active] 226900006518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006519 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900006520 putative substrate translocation pore; other site 226900006521 Condensation domain; Region: Condensation; cl19241 226900006522 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 226900006523 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 226900006524 acyl-activating enzyme (AAE) consensus motif; other site 226900006525 AMP binding site [chemical binding]; other site 226900006526 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 226900006527 Condensation domain; Region: Condensation; pfam00668 226900006528 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 226900006529 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 226900006530 Condensation domain; Region: Condensation; pfam00668 226900006531 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 226900006532 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 226900006533 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 226900006534 acyl-activating enzyme (AAE) consensus motif; other site 226900006535 AMP binding site [chemical binding]; other site 226900006536 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 226900006537 Condensation domain; Region: Condensation; pfam00668 226900006538 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 226900006539 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 226900006540 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 226900006541 acyl-activating enzyme (AAE) consensus motif; other site 226900006542 AMP binding site [chemical binding]; other site 226900006543 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 226900006544 Condensation domain; Region: Condensation; cl19241 226900006545 Condensation domain; Region: Condensation; cl19241 226900006546 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 226900006547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226900006548 acyl-activating enzyme (AAE) consensus motif; other site 226900006549 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 226900006550 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 226900006551 acyl-activating enzyme (AAE) consensus motif; other site 226900006552 AMP binding site [chemical binding]; other site 226900006553 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 226900006554 Condensation domain; Region: Condensation; pfam00668 226900006555 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 226900006556 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 226900006557 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 226900006558 acyl-activating enzyme (AAE) consensus motif; other site 226900006559 AMP binding site [chemical binding]; other site 226900006560 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 226900006561 Condensation domain; Region: Condensation; pfam00668 226900006562 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 226900006563 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 226900006564 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 226900006565 Condensation domain; Region: Condensation; pfam00668 226900006566 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 226900006567 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 226900006568 acyl-activating enzyme (AAE) consensus motif; other site 226900006569 AMP binding site [chemical binding]; other site 226900006570 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 226900006571 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 226900006572 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 226900006573 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 226900006574 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 226900006575 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900006576 Erythromycin esterase; Region: Erythro_esteras; cl17110 226900006577 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 226900006578 N-acetyl-D-glucosamine binding site [chemical binding]; other site 226900006579 catalytic residue [active] 226900006580 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900006581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900006582 S-layer homology domain; Region: SLH; pfam00395 226900006583 S-layer homology domain; Region: SLH; pfam00395 226900006584 S-layer homology domain; Region: SLH; pfam00395 226900006585 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 226900006586 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 226900006587 FOG: PKD repeat [General function prediction only]; Region: COG3291 226900006588 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 226900006589 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900006590 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900006591 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 226900006592 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900006593 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 226900006594 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900006595 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226900006596 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900006597 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900006598 DNA binding residues [nucleotide binding] 226900006599 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 226900006600 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900006601 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900006602 similar to Penicillin-binding protein transpeptidase 226900006603 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900006604 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 226900006605 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900006606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006607 Coenzyme A binding pocket [chemical binding]; other site 226900006608 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 226900006609 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900006610 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226900006611 putative active site [active] 226900006612 putative metal binding site [ion binding]; other site 226900006613 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900006614 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226900006615 Walker A/P-loop; other site 226900006616 ATP binding site [chemical binding]; other site 226900006617 Q-loop/lid; other site 226900006618 ABC transporter signature motif; other site 226900006619 Walker B; other site 226900006620 D-loop; other site 226900006621 H-loop/switch region; other site 226900006622 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 226900006623 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 226900006624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900006625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900006626 Protein of unknown function (DUF523); Region: DUF523; pfam04463 226900006627 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 226900006628 similar to Acyl-CoA dehydrogenase, short-chain specific; EC_number 1.3.99.2 226900006629 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 226900006630 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900006631 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226900006632 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 226900006633 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226900006634 carboxyltransferase (CT) interaction site; other site 226900006635 biotinylation site [posttranslational modification]; other site 226900006636 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 226900006637 active site 226900006638 catalytic residues [active] 226900006639 metal binding site [ion binding]; metal-binding site 226900006640 enoyl-CoA hydratase; Provisional; Region: PRK07657 226900006641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900006642 substrate binding site [chemical binding]; other site 226900006643 oxyanion hole (OAH) forming residues; other site 226900006644 trimer interface [polypeptide binding]; other site 226900006645 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 226900006646 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226900006647 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226900006648 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 226900006649 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 226900006650 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 226900006651 acyl-activating enzyme (AAE) consensus motif; other site 226900006652 putative AMP binding site [chemical binding]; other site 226900006653 putative active site [active] 226900006654 putative CoA binding site [chemical binding]; other site 226900006655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900006656 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900006657 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900006658 Herpesvirus BLRF2 protein; Region: Herpes_BLRF2; pfam05812 226900006659 putative transposase OrfB; Reviewed; Region: PHA02517 226900006660 HTH-like domain; Region: HTH_21; pfam13276 226900006661 Integrase core domain; Region: rve; pfam00665 226900006662 Integrase core domain; Region: rve_2; pfam13333 226900006663 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900006664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006665 Coenzyme A binding pocket [chemical binding]; other site 226900006666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900006667 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900006668 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900006669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900006670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900006671 dimer interface [polypeptide binding]; other site 226900006672 phosphorylation site [posttranslational modification] 226900006673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900006674 ATP binding site [chemical binding]; other site 226900006675 Mg2+ binding site [ion binding]; other site 226900006676 G-X-G motif; other site 226900006677 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900006678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900006679 active site 226900006680 phosphorylation site [posttranslational modification] 226900006681 intermolecular recognition site; other site 226900006682 dimerization interface [polypeptide binding]; other site 226900006683 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900006684 DNA binding site [nucleotide binding] 226900006685 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900006686 Zn2+ binding site [ion binding]; other site 226900006687 Mg2+ binding site [ion binding]; other site 226900006688 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 226900006689 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 226900006690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006691 Coenzyme A binding pocket [chemical binding]; other site 226900006692 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900006693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900006694 Coenzyme A binding pocket [chemical binding]; other site 226900006695 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 226900006696 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900006697 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900006698 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900006699 active site 226900006700 Zn binding site [ion binding]; other site 226900006701 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226900006702 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 226900006703 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226900006704 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226900006705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900006706 Cna protein B-type domain; Region: Cna_B; pfam05738 226900006707 Cna protein B-type domain; Region: Cna_B; pfam05738 226900006708 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900006709 Cna protein B-type domain; Region: Cna_B; pfam05738 226900006710 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226900006711 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 226900006712 active site 226900006713 catalytic site [active] 226900006714 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 226900006715 Cna protein B-type domain; Region: Cna_B; pfam05738 226900006716 Cna protein B-type domain; Region: Cna_B; pfam05738 226900006717 Cna protein B-type domain; Region: Cna_B; pfam05738 226900006718 Cna protein B-type domain; Region: Cna_B; pfam05738 226900006719 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226900006720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 226900006721 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 226900006722 putative hydrophobic ligand binding site [chemical binding]; other site 226900006723 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 226900006724 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 226900006725 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 226900006726 AAA domain; Region: AAA_22; pfam13401 226900006727 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 226900006728 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 226900006729 DNA binding residues [nucleotide binding] 226900006730 drug binding residues [chemical binding]; other site 226900006731 dimer interface [polypeptide binding]; other site 226900006732 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 226900006733 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900006734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006735 putative substrate translocation pore; other site 226900006736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006737 short chain dehydrogenase; Provisional; Region: PRK07041 226900006738 NAD(P) binding site [chemical binding]; other site 226900006739 active site 226900006740 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 226900006741 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900006742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006743 S-adenosylmethionine binding site [chemical binding]; other site 226900006744 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900006745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900006746 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 226900006747 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900006748 Phosphotransferase enzyme family; Region: APH; pfam01636 226900006749 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 226900006750 active site 226900006751 substrate binding site [chemical binding]; other site 226900006752 ATP binding site [chemical binding]; other site 226900006753 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 226900006754 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 226900006755 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 226900006756 active site 226900006757 Zn binding site [ion binding]; other site 226900006758 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 226900006759 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900006760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900006761 DNA-binding site [nucleotide binding]; DNA binding site 226900006762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900006763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900006764 homodimer interface [polypeptide binding]; other site 226900006765 catalytic residue [active] 226900006766 CAAX protease self-immunity; Region: Abi; pfam02517 226900006767 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 226900006768 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 226900006769 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 226900006770 putative NAD(P) binding site [chemical binding]; other site 226900006771 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900006772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900006773 NAD(P) binding site [chemical binding]; other site 226900006774 active site 226900006775 Predicted membrane protein [Function unknown]; Region: COG2323 226900006776 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900006777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006778 S-adenosylmethionine binding site [chemical binding]; other site 226900006779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900006780 S-adenosylmethionine binding site [chemical binding]; other site 226900006781 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 226900006782 Strictosidine synthase; Region: Str_synth; cl19733 226900006783 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 226900006784 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 226900006785 active site 226900006786 HIGH motif; other site 226900006787 KMSKS motif; other site 226900006788 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 226900006789 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 226900006790 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 226900006791 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900006792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900006793 active site 226900006794 phosphorylation site [posttranslational modification] 226900006795 intermolecular recognition site; other site 226900006796 dimerization interface [polypeptide binding]; other site 226900006797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900006798 DNA binding site [nucleotide binding] 226900006799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900006800 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 226900006801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900006802 ATP binding site [chemical binding]; other site 226900006803 Mg2+ binding site [ion binding]; other site 226900006804 G-X-G motif; other site 226900006805 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 226900006806 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900006807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900006808 ABC transporter; Region: ABC_tran_2; pfam12848 226900006809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900006810 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900006811 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900006812 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900006813 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900006814 Walker A/P-loop; other site 226900006815 ATP binding site [chemical binding]; other site 226900006816 Q-loop/lid; other site 226900006817 ABC transporter signature motif; other site 226900006818 Walker B; other site 226900006819 D-loop; other site 226900006820 H-loop/switch region; other site 226900006821 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900006822 FtsX-like permease family; Region: FtsX; pfam02687 226900006823 FtsX-like permease family; Region: FtsX; pfam02687 226900006824 hypothetical protein; Provisional; Region: PRK06760 226900006825 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 226900006826 similar to Lipase; EC_number 3.1.1.3 226900006827 homoserine dehydrogenase; Validated; Region: PRK06813 226900006828 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 226900006829 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900006830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900006831 DNA-binding site [nucleotide binding]; DNA binding site 226900006832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900006833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900006834 homodimer interface [polypeptide binding]; other site 226900006835 catalytic residue [active] 226900006836 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 226900006837 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 226900006838 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226900006839 Putative transcription activator [Transcription]; Region: TenA; COG0819 226900006840 Bacteriophage phBC6A52; identified by comparison with Bacillus anthracis 226900006841 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 226900006842 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 226900006843 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 226900006844 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 226900006845 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 226900006846 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 226900006847 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 226900006848 Int/Topo IB signature motif; other site 226900006849 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900006850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900006851 non-specific DNA binding site [nucleotide binding]; other site 226900006852 salt bridge; other site 226900006853 sequence-specific DNA binding site [nucleotide binding]; other site 226900006854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900006855 non-specific DNA binding site [nucleotide binding]; other site 226900006856 salt bridge; other site 226900006857 sequence-specific DNA binding site [nucleotide binding]; other site 226900006858 Helix-turn-helix domain; Region: HTH_17; pfam12728 226900006859 Helix-turn-helix domain; Region: HTH_36; pfam13730 226900006860 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 226900006861 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 226900006862 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 226900006863 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 226900006864 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900006865 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900006866 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900006867 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900006868 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 226900006869 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 226900006870 Int/Topo IB signature motif; other site 226900006871 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 226900006872 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 226900006873 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 226900006874 active site 226900006875 Phage terminase, small subunit; Region: Terminase_4; cl01525 226900006876 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 226900006877 Phage Terminase; Region: Terminase_1; cl19862 226900006878 Phage portal protein; Region: Phage_portal; cl19194 226900006879 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 226900006880 Phage capsid family; Region: Phage_capsid; pfam05065 226900006881 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 226900006882 oligomerization interface [polypeptide binding]; other site 226900006883 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 226900006884 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; cl12124 226900006885 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 226900006886 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226900006887 Phage-related minor tail protein [Function unknown]; Region: COG5280 226900006888 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 226900006889 membrane protein P6; Region: PHA01399 226900006890 Phage-related protein [Function unknown]; Region: COG5412 226900006891 Phage-related minor tail protein [Function unknown]; Region: COG5281 226900006892 Phage tail protein; Region: Sipho_tail; cl17486 226900006893 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 226900006894 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 226900006895 Holin family; Region: Phage_holin_4; pfam05105 226900006896 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 226900006897 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900006898 active site 226900006899 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 226900006900 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 226900006901 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 226900006902 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 226900006903 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 226900006904 Protein of unknown function; Region: DUF3658; pfam12395 226900006905 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 226900006906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900006907 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900006908 putative substrate translocation pore; other site 226900006909 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 226900006910 trimer interface [polypeptide binding]; other site 226900006911 active site 226900006912 substrate binding site [chemical binding]; other site 226900006913 CoA binding site [chemical binding]; other site 226900006914 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 226900006915 Cytochrome P450; Region: p450; cl12078 226900006916 Transposase IS200 like; Region: Y1_Tnp; pfam01797 226900006917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 226900006918 Probable transposase; Region: OrfB_IS605; pfam01385 226900006919 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900006920 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900006921 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 226900006922 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 226900006923 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900006924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900006925 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900006926 active site 226900006927 motif I; other site 226900006928 motif II; other site 226900006929 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900006930 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226900006931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900006932 dimer interface [polypeptide binding]; other site 226900006933 phosphorylation site [posttranslational modification] 226900006934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900006935 ATP binding site [chemical binding]; other site 226900006936 Mg2+ binding site [ion binding]; other site 226900006937 G-X-G motif; other site 226900006938 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900006939 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900006940 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900006941 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900006942 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900006943 Catalytic site [active] 226900006944 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 226900006945 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 226900006946 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 226900006947 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 226900006948 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226900006949 active site 226900006950 catalytic residues [active] 226900006951 DNA binding site [nucleotide binding] 226900006952 Int/Topo IB signature motif; other site 226900006953 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226900006954 active site 226900006955 catalytic residues [active] 226900006956 DNA binding site [nucleotide binding] 226900006957 Int/Topo IB signature motif; other site 226900006958 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226900006959 active site 226900006960 catalytic residues [active] 226900006961 DNA binding site [nucleotide binding] 226900006962 Int/Topo IB signature motif; other site 226900006963 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 226900006964 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 226900006965 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 226900006966 substrate binding site [chemical binding]; other site 226900006967 active site 226900006968 cosubstrate binding site; other site 226900006969 catalytic site [active] 226900006970 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cd08370 226900006971 hypothetical protein; Validated; Region: PRK08223 226900006972 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 226900006973 ATP binding site [chemical binding]; other site 226900006974 substrate interface [chemical binding]; other site 226900006975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900006976 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900006977 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 226900006978 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 226900006979 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900006980 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 226900006981 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 226900006982 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006983 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006984 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006985 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006986 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006987 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006988 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006989 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006990 Domain of unknown function DUF11; Region: DUF11; cl17728 226900006991 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006992 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006993 Domain of unknown function DUF11; Region: DUF11; cl17728 226900006994 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006995 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006996 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006997 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006998 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900006999 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007000 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007001 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007002 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007003 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007004 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007005 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007006 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007007 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007008 Domain of unknown function DUF11; Region: DUF11; cl17728 226900007009 Domain of unknown function DUF11; Region: DUF11; cl17728 226900007010 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007011 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007012 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900007013 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 226900007014 catalytic triad [active] 226900007015 conserved cis-peptide bond; other site 226900007016 similar to Transposase 226900007017 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 226900007018 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900007019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900007020 motif II; other site 226900007021 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 226900007022 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007024 Coenzyme A binding pocket [chemical binding]; other site 226900007025 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 226900007026 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 226900007027 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 226900007028 putative active site [active] 226900007029 putative NTP binding site [chemical binding]; other site 226900007030 putative nucleic acid binding site [nucleotide binding]; other site 226900007031 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 226900007032 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 226900007033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900007034 non-specific DNA binding site [nucleotide binding]; other site 226900007035 salt bridge; other site 226900007036 sequence-specific DNA binding site [nucleotide binding]; other site 226900007037 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 226900007038 active site 226900007039 Endoplasmic Reticulum Oxidoreductin 1 (ERO1); Region: ERO1; cl19883 226900007040 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 226900007041 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 226900007042 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226900007043 Walker A/P-loop; other site 226900007044 ATP binding site [chemical binding]; other site 226900007045 Q-loop/lid; other site 226900007046 ABC transporter signature motif; other site 226900007047 Walker B; other site 226900007048 D-loop; other site 226900007049 H-loop/switch region; other site 226900007050 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 226900007051 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 226900007052 Walker A/P-loop; other site 226900007053 ATP binding site [chemical binding]; other site 226900007054 Q-loop/lid; other site 226900007055 ABC transporter signature motif; other site 226900007056 Walker B; other site 226900007057 D-loop; other site 226900007058 H-loop/switch region; other site 226900007059 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 226900007060 similar to Sporulation kinase; EC_number 2.7.3.- 226900007061 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 226900007062 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 226900007063 active site 226900007064 ATP binding site [chemical binding]; other site 226900007065 substrate binding site [chemical binding]; other site 226900007066 activation loop (A-loop); other site 226900007067 GrpB protein; Region: GrpB; pfam04229 226900007068 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900007069 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 226900007070 NAD(P) binding site [chemical binding]; other site 226900007071 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 226900007072 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 226900007073 active site 226900007074 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900007075 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900007076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900007077 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 226900007078 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 226900007079 similar to Lysine-specific permease 226900007080 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 226900007081 VanZ like family; Region: VanZ; pfam04892 226900007082 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 226900007083 EDD domain protein, DegV family; Region: DegV; TIGR00762 226900007084 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 226900007085 conserved cys residue [active] 226900007086 Predicted transcriptional regulator [Transcription]; Region: COG2378 226900007087 HTH domain; Region: HTH_11; pfam08279 226900007088 WYL domain; Region: WYL; pfam13280 226900007089 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 226900007090 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 226900007091 conserved cys residue [active] 226900007092 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900007093 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 226900007094 DNA binding residues [nucleotide binding] 226900007095 putative dimer interface [polypeptide binding]; other site 226900007096 Trm112p-like protein; Region: Trm112p; pfam03966 226900007097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900007098 S-adenosylmethionine binding site [chemical binding]; other site 226900007099 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900007100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007101 putative substrate translocation pore; other site 226900007102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007103 Coenzyme A binding pocket [chemical binding]; other site 226900007104 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 226900007105 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226900007106 active site 226900007107 catalytic site [active] 226900007108 metal binding site [ion binding]; metal-binding site 226900007109 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 226900007110 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900007111 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900007112 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 226900007113 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900007114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900007115 DNA-binding site [nucleotide binding]; DNA binding site 226900007116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900007117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007118 homodimer interface [polypeptide binding]; other site 226900007119 catalytic residue [active] 226900007120 EamA-like transporter family; Region: EamA; pfam00892 226900007121 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900007122 EamA-like transporter family; Region: EamA; pfam00892 226900007123 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 226900007124 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 226900007125 active site 226900007126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007127 Coenzyme A binding pocket [chemical binding]; other site 226900007128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 226900007129 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 226900007130 nudix motif; other site 226900007131 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 226900007132 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900007133 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 226900007134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007135 putative substrate translocation pore; other site 226900007136 Cadmium resistance transporter; Region: Cad; cl19409 226900007137 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900007138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007139 Coenzyme A binding pocket [chemical binding]; other site 226900007140 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900007141 nudix motif; other site 226900007142 DNA polymerase III subunit beta; Validated; Region: PRK06673 226900007143 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 226900007144 putative DNA binding surface [nucleotide binding]; other site 226900007145 dimer interface [polypeptide binding]; other site 226900007146 beta-clamp/clamp loader binding surface; other site 226900007147 beta-clamp/translesion DNA polymerase binding surface; other site 226900007148 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 226900007149 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 226900007150 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 226900007151 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 226900007152 homotrimer interaction site [polypeptide binding]; other site 226900007153 putative active site [active] 226900007154 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 226900007155 similar to Esterase 226900007156 YxiJ-like protein; Region: YxiJ; pfam14176 226900007157 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 226900007158 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 226900007159 active site 226900007160 nucleophile elbow; other site 226900007161 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 226900007162 pentamer interface [polypeptide binding]; other site 226900007163 dodecaamer interface [polypeptide binding]; other site 226900007164 metal-dependent hydrolase; Provisional; Region: PRK13291 226900007165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007166 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900007167 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 226900007168 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 226900007169 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 226900007170 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 226900007171 GIY-YIG motif/motif A; other site 226900007172 active site 226900007173 catalytic site [active] 226900007174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007176 Coenzyme A binding pocket [chemical binding]; other site 226900007177 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 226900007178 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900007179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900007180 Walker A/P-loop; other site 226900007181 ATP binding site [chemical binding]; other site 226900007182 Q-loop/lid; other site 226900007183 ABC transporter signature motif; other site 226900007184 Walker B; other site 226900007185 D-loop; other site 226900007186 H-loop/switch region; other site 226900007187 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 226900007188 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 226900007189 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 226900007190 active site 226900007191 ATP binding site [chemical binding]; other site 226900007192 substrate binding site [chemical binding]; other site 226900007193 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 226900007194 nudix motif; other site 226900007195 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 226900007196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900007197 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 226900007198 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 226900007199 MepB protein; Region: MepB; cl01985 226900007200 MepB protein; Region: MepB; cl01985 226900007201 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 226900007202 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900007203 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 226900007204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900007205 motif II; other site 226900007206 DinB superfamily; Region: DinB_2; pfam12867 226900007207 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900007208 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 226900007209 carbohydrate binding site [chemical binding]; other site 226900007210 pullulanase, type I; Region: pulA_typeI; TIGR02104 226900007211 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 226900007212 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 226900007213 Ca binding site [ion binding]; other site 226900007214 active site 226900007215 catalytic site [active] 226900007216 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 226900007217 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900007218 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900007219 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900007220 active site 226900007221 Zn binding site [ion binding]; other site 226900007222 similar to CLV1 receptor kinase 226900007223 DinB superfamily; Region: DinB_2; pfam12867 226900007224 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 226900007225 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 226900007226 putative metal binding site [ion binding]; other site 226900007227 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 226900007228 SecY translocase; Region: SecY; pfam00344 226900007229 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 226900007230 EamA-like transporter family; Region: EamA; pfam00892 226900007231 EamA-like transporter family; Region: EamA; pfam00892 226900007232 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900007233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900007234 DNA-binding site [nucleotide binding]; DNA binding site 226900007235 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900007236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007237 homodimer interface [polypeptide binding]; other site 226900007238 catalytic residue [active] 226900007239 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 226900007240 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900007241 TAP-like protein; Region: Abhydrolase_4; pfam08386 226900007242 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 226900007243 Mg binding site [ion binding]; other site 226900007244 nucleotide binding site [chemical binding]; other site 226900007245 putative protofilament interface [polypeptide binding]; other site 226900007246 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 226900007247 Predicted membrane protein [Function unknown]; Region: COG4129 226900007248 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 226900007249 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900007250 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 226900007251 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 226900007252 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 226900007253 germination protein YpeB; Region: spore_YpeB; TIGR02889 226900007254 YpeB sporulation; Region: YPEB; pfam14620 226900007255 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 226900007256 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 226900007257 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 226900007258 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 226900007259 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 226900007260 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 226900007261 Putative cyclase; Region: Cyclase; cl00814 226900007262 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 226900007263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900007264 catalytic residue [active] 226900007265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900007266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900007267 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 226900007268 nudix motif; other site 226900007269 N-acetyltransferase; Region: Acetyltransf_2; cl00949 226900007270 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 226900007271 hydrophobic ligand binding site; other site 226900007272 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 226900007273 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 226900007274 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 226900007275 GAF domain; Region: GAF; pfam01590 226900007276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900007277 Walker A motif; other site 226900007278 ATP binding site [chemical binding]; other site 226900007279 Walker B motif; other site 226900007280 arginine finger; other site 226900007281 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226900007282 NIPSNAP; Region: NIPSNAP; pfam07978 226900007283 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007285 Coenzyme A binding pocket [chemical binding]; other site 226900007286 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226900007287 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 226900007288 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 226900007289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900007290 S-adenosylmethionine binding site [chemical binding]; other site 226900007291 Predicted transcriptional regulator [Transcription]; Region: COG1959 226900007292 Rrf2 family protein; Region: rrf2_super; TIGR00738 226900007293 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 226900007294 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 226900007295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900007296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900007297 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226900007298 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 226900007299 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226900007300 E3 interaction surface; other site 226900007301 lipoyl attachment site [posttranslational modification]; other site 226900007302 e3 binding domain; Region: E3_binding; pfam02817 226900007303 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 226900007304 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 226900007305 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 226900007306 alpha subunit interface [polypeptide binding]; other site 226900007307 TPP binding site [chemical binding]; other site 226900007308 heterodimer interface [polypeptide binding]; other site 226900007309 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900007310 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 226900007311 tetramer interface [polypeptide binding]; other site 226900007312 TPP-binding site [chemical binding]; other site 226900007313 heterodimer interface [polypeptide binding]; other site 226900007314 phosphorylation loop region [posttranslational modification] 226900007315 DinB superfamily; Region: DinB_2; pfam12867 226900007316 short chain dehydrogenase; Provisional; Region: PRK06914 226900007317 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 226900007318 NADP binding site [chemical binding]; other site 226900007319 active site 226900007320 steroid binding site; other site 226900007321 GrpB protein; Region: GrpB; pfam04229 226900007322 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 226900007323 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 226900007324 nudix motif; other site 226900007325 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 226900007326 Protein phosphatase 2C; Region: PP2C_2; pfam13672 226900007327 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 226900007328 nucleotide binding site/active site [active] 226900007329 HIT family signature motif; other site 226900007330 catalytic residue [active] 226900007331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900007332 dimer interface [polypeptide binding]; other site 226900007333 conserved gate region; other site 226900007334 putative PBP binding loops; other site 226900007335 ABC-ATPase subunit interface; other site 226900007336 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 226900007337 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 226900007338 Walker A/P-loop; other site 226900007339 ATP binding site [chemical binding]; other site 226900007340 Q-loop/lid; other site 226900007341 ABC transporter signature motif; other site 226900007342 Walker B; other site 226900007343 D-loop; other site 226900007344 H-loop/switch region; other site 226900007345 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 226900007346 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 226900007347 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 226900007348 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 226900007349 oligomer interface [polypeptide binding]; other site 226900007350 active site residues [active] 226900007351 RNA polymerase factor sigma-70; Validated; Region: PRK06704 226900007352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900007353 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 226900007354 DNA binding residues [nucleotide binding] 226900007355 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900007356 catalytic loop [active] 226900007357 iron binding site [ion binding]; other site 226900007358 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 226900007359 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900007360 active site 226900007361 dimer interface [polypeptide binding]; other site 226900007362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007363 Coenzyme A binding pocket [chemical binding]; other site 226900007364 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 226900007365 Chitin binding domain; Region: Chitin_bind_3; pfam03067 226900007366 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226900007367 Interdomain contacts; other site 226900007368 Cytokine receptor motif; other site 226900007369 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 226900007370 Interdomain contacts; other site 226900007371 Cytokine receptor motif; other site 226900007372 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 226900007373 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 226900007374 glycosyltransferase, MGT family; Region: MGT; TIGR01426 226900007375 active site 226900007376 TDP-binding site; other site 226900007377 acceptor substrate-binding pocket; other site 226900007378 homodimer interface [polypeptide binding]; other site 226900007379 Uncharacterized conserved protein [Function unknown]; Region: COG1262 226900007380 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 226900007381 topology modulation protein; Reviewed; Region: PRK08118 226900007382 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 226900007383 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 226900007384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900007385 S-adenosylmethionine binding site [chemical binding]; other site 226900007386 DNA methylase; Region: N6_N4_Mtase; cl17433 226900007387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 226900007388 similar to Acetyltransferase; EC_number 2.3.1.- 226900007389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007390 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900007391 Coenzyme A binding pocket [chemical binding]; other site 226900007392 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 226900007393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007395 Coenzyme A binding pocket [chemical binding]; other site 226900007396 Predicted transcriptional regulators [Transcription]; Region: COG1695 226900007397 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900007398 similar to ATP-dependent DNA helicase rep; EC_number 3.6.1.- 226900007399 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 226900007400 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 226900007401 putative active site pocket [active] 226900007402 dimerization interface [polypeptide binding]; other site 226900007403 putative catalytic residue [active] 226900007404 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 226900007405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900007406 ATP binding site [chemical binding]; other site 226900007407 putative Mg++ binding site [ion binding]; other site 226900007408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900007409 nucleotide binding region [chemical binding]; other site 226900007410 ATP-binding site [chemical binding]; other site 226900007411 RQC domain; Region: RQC; pfam09382 226900007412 HRDC domain; Region: HRDC; pfam00570 226900007413 Helix-turn-helix domain; Region: HTH_40; pfam14493 226900007414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900007415 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900007416 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900007417 Herpesvirus BLRF2 protein; Region: Herpes_BLRF2; pfam05812 226900007418 putative transposase OrfB; Reviewed; Region: PHA02517 226900007419 HTH-like domain; Region: HTH_21; pfam13276 226900007420 Integrase core domain; Region: rve; pfam00665 226900007421 Integrase core domain; Region: rve_2; pfam13333 226900007422 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 226900007423 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900007424 active site 226900007425 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 226900007426 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900007427 active site 226900007428 metal binding site [ion binding]; metal-binding site 226900007429 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 226900007430 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 226900007431 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 226900007432 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 226900007433 DHHA2 domain; Region: DHHA2; pfam02833 226900007434 Chitin binding domain; Region: Chitin_bind_3; pfam03067 226900007435 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900007436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007437 Coenzyme A binding pocket [chemical binding]; other site 226900007438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900007439 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900007440 Zn2+ binding site [ion binding]; other site 226900007441 Mg2+ binding site [ion binding]; other site 226900007442 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 226900007443 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 226900007444 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 226900007445 NAD(P) binding site [chemical binding]; other site 226900007446 catalytic residues [active] 226900007447 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 226900007448 inhibitor site; inhibition site 226900007449 active site 226900007450 dimer interface [polypeptide binding]; other site 226900007451 catalytic residue [active] 226900007452 Proline racemase; Region: Pro_racemase; pfam05544 226900007453 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 226900007454 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 226900007455 Proline racemase; Region: Pro_racemase; pfam05544 226900007456 FAD dependent oxidoreductase; Region: DAO; pfam01266 226900007457 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900007458 PAS domain; Region: PAS; smart00091 226900007459 PAS domain; Region: PAS_9; pfam13426 226900007460 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 226900007461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900007462 Walker A motif; other site 226900007463 ATP binding site [chemical binding]; other site 226900007464 Walker B motif; other site 226900007465 arginine finger; other site 226900007466 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226900007467 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 226900007468 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900007469 catalytic loop [active] 226900007470 iron binding site [ion binding]; other site 226900007471 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 226900007472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900007473 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 226900007474 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 226900007475 similar to Alkaline phosphatase like protein 226900007476 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 226900007477 DltD N-terminal region; Region: DltD_N; pfam04915 226900007478 DltD central region; Region: DltD_M; pfam04918 226900007479 DltD C-terminal region; Region: DltD_C; pfam04914 226900007480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007481 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900007482 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900007483 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900007484 peptide binding site [polypeptide binding]; other site 226900007485 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900007486 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 226900007487 NlpC/P60 family; Region: NLPC_P60; pfam00877 226900007488 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 226900007489 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 226900007490 active site 226900007491 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 226900007492 Septum formation initiator; Region: DivIC; pfam04977 226900007493 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900007494 active site 226900007495 catalytic tetrad [active] 226900007496 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 226900007497 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 226900007498 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 226900007499 conserved cys residue [active] 226900007500 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 226900007501 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226900007502 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226900007503 AAA domain; Region: AAA_18; pfam13238 226900007504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900007505 S-adenosylmethionine binding site [chemical binding]; other site 226900007506 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 226900007507 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226900007508 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 226900007509 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 226900007510 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 226900007511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900007512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900007513 dimerization interface [polypeptide binding]; other site 226900007514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900007515 dimer interface [polypeptide binding]; other site 226900007516 phosphorylation site [posttranslational modification] 226900007517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900007518 ATP binding site [chemical binding]; other site 226900007519 Mg2+ binding site [ion binding]; other site 226900007520 G-X-G motif; other site 226900007521 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900007522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900007523 active site 226900007524 phosphorylation site [posttranslational modification] 226900007525 intermolecular recognition site; other site 226900007526 dimerization interface [polypeptide binding]; other site 226900007527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900007528 DNA binding site [nucleotide binding] 226900007529 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900007530 similar to S-adenosylhomocysteine nucleotidase; EC_number 3.2.2.9 226900007531 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 226900007532 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 226900007533 Zn binding site [ion binding]; other site 226900007534 EDD domain protein, DegV family; Region: DegV; TIGR00762 226900007535 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 226900007536 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 226900007537 Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA; Region: Topoisomer_IB_N; cl02774 226900007538 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 226900007539 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 226900007540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007541 Coenzyme A binding pocket [chemical binding]; other site 226900007542 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 226900007543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900007545 putative substrate translocation pore; other site 226900007546 Protein of unknown function (DUF342); Region: DUF342; cl19219 226900007547 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 226900007548 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 226900007549 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 226900007550 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 226900007551 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 226900007552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900007554 putative substrate translocation pore; other site 226900007555 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 226900007556 Predicted membrane protein [Function unknown]; Region: COG2261 226900007557 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 226900007558 active site 226900007559 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 226900007560 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900007561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900007562 S-adenosylmethionine binding site [chemical binding]; other site 226900007563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007564 putative substrate translocation pore; other site 226900007565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900007566 aspartate aminotransferase; Provisional; Region: PRK07681 226900007567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900007568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007569 homodimer interface [polypeptide binding]; other site 226900007570 catalytic residue [active] 226900007571 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 226900007572 pantothenate kinase; Provisional; Region: PRK13317 226900007573 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 226900007574 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 226900007575 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 226900007576 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900007577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900007578 Walker A/P-loop; other site 226900007579 ATP binding site [chemical binding]; other site 226900007580 Q-loop/lid; other site 226900007581 ABC transporter signature motif; other site 226900007582 Walker B; other site 226900007583 D-loop; other site 226900007584 H-loop/switch region; other site 226900007585 DinB family; Region: DinB; cl17821 226900007586 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226900007587 HNH endonuclease; Region: HNH_5; pfam14279 226900007588 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 226900007589 active site 226900007590 dimer interface [polypeptide binding]; other site 226900007591 non-prolyl cis peptide bond; other site 226900007592 insertion regions; other site 226900007593 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 226900007594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900007595 dimer interface [polypeptide binding]; other site 226900007596 conserved gate region; other site 226900007597 putative PBP binding loops; other site 226900007598 ABC-ATPase subunit interface; other site 226900007599 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 226900007600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900007601 substrate binding pocket [chemical binding]; other site 226900007602 membrane-bound complex binding site; other site 226900007603 hinge residues; other site 226900007604 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226900007605 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 226900007606 Walker A/P-loop; other site 226900007607 ATP binding site [chemical binding]; other site 226900007608 Q-loop/lid; other site 226900007609 ABC transporter signature motif; other site 226900007610 Walker B; other site 226900007611 D-loop; other site 226900007612 H-loop/switch region; other site 226900007613 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900007614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900007615 Protein of unknown function (DUF402); Region: DUF402; pfam04167 226900007616 Tetratrico peptide repeat; Region: TPR_5; pfam12688 226900007617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900007618 binding surface 226900007619 TPR motif; other site 226900007620 hypothetical protein; Provisional; Region: PRK09620 226900007621 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 226900007622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007623 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900007624 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 226900007625 Coenzyme A binding pocket [chemical binding]; other site 226900007626 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 226900007627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007629 Coenzyme A binding pocket [chemical binding]; other site 226900007630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900007632 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226900007633 active site 226900007634 NTP binding site [chemical binding]; other site 226900007635 metal binding triad [ion binding]; metal-binding site 226900007636 antibiotic binding site [chemical binding]; other site 226900007637 A new structural DNA glycosylase; Region: AlkD_like; cd06561 226900007638 active site 226900007639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900007640 active site 226900007641 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 226900007642 iron binding site [ion binding]; other site 226900007643 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900007644 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226900007645 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 226900007646 NodB motif; other site 226900007647 active site 226900007648 catalytic site [active] 226900007649 Zn binding site [ion binding]; other site 226900007650 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 226900007651 Integral membrane protein TerC family; Region: TerC; cl10468 226900007652 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226900007653 Sulfatase; Region: Sulfatase; pfam00884 226900007654 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 226900007655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900007656 ABC transporter; Region: ABC_tran_2; pfam12848 226900007657 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900007658 hypothetical protein; Provisional; Region: PRK06761 226900007659 similar to Transporter, MMPL family 226900007660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900007661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900007662 Sterol carrier protein domain; Region: SCP2_2; pfam13530 226900007663 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 226900007664 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 226900007665 hinge; other site 226900007666 active site 226900007667 prephenate dehydrogenase; Validated; Region: PRK06545 226900007668 prephenate dehydrogenase; Validated; Region: PRK08507 226900007669 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 226900007670 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 226900007671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900007672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007673 homodimer interface [polypeptide binding]; other site 226900007674 catalytic residue [active] 226900007675 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 226900007676 Tetramer interface [polypeptide binding]; other site 226900007677 active site 226900007678 FMN-binding site [chemical binding]; other site 226900007679 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 226900007680 Chorismate mutase type II; Region: CM_2; cl00693 226900007681 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 226900007682 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 226900007683 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 226900007684 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 226900007685 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900007686 catalytic triad [active] 226900007687 conserved cis-peptide bond; other site 226900007688 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007690 Coenzyme A binding pocket [chemical binding]; other site 226900007691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900007692 YfzA-like protein; Region: YfzA; pfam14118 226900007693 hypothetical protein; Provisional; Region: PRK06762 226900007694 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900007695 Bacterial SH3 domain homologues; Region: SH3b; smart00287 226900007696 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 226900007697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 226900007698 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 226900007699 putative metal binding site [ion binding]; other site 226900007700 Berberine and berberine like; Region: BBE; pfam08031 226900007701 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 226900007702 malate:quinone oxidoreductase; Validated; Region: PRK05257 226900007703 Predicted dehydrogenase [General function prediction only]; Region: COG0579 226900007704 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 226900007705 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 226900007706 ligand binding site [chemical binding]; other site 226900007707 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 226900007708 TM-ABC transporter signature motif; other site 226900007709 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 226900007710 TM-ABC transporter signature motif; other site 226900007711 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 226900007712 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 226900007713 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 226900007714 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 226900007715 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 226900007716 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 226900007717 putative N- and C-terminal domain interface [polypeptide binding]; other site 226900007718 putative active site [active] 226900007719 putative MgATP binding site [chemical binding]; other site 226900007720 catalytic site [active] 226900007721 metal binding site [ion binding]; metal-binding site 226900007722 putative carbohydrate binding site [chemical binding]; other site 226900007723 Cupin domain; Region: Cupin_2; pfam07883 226900007724 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 226900007725 putative active site; other site 226900007726 catalytic residue [active] 226900007727 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900007728 active site 226900007729 metal binding site [ion binding]; metal-binding site 226900007730 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 226900007731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007732 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900007733 putative substrate translocation pore; other site 226900007734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900007735 dimerization interface [polypeptide binding]; other site 226900007736 putative DNA binding site [nucleotide binding]; other site 226900007737 putative Zn2+ binding site [ion binding]; other site 226900007738 DinB superfamily; Region: DinB_2; pfam12867 226900007739 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900007740 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900007741 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900007742 similar to Gamma-glutamyl phosphate reductase (GPR); EC_number 1.2.1.41 226900007743 gamma-glutamyl kinase; Provisional; Region: PRK05429 226900007744 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 226900007745 nucleotide binding site [chemical binding]; other site 226900007746 homotetrameric interface [polypeptide binding]; other site 226900007747 putative phosphate binding site [ion binding]; other site 226900007748 putative allosteric binding site; other site 226900007749 PUA domain; Region: PUA; pfam01472 226900007750 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 226900007751 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 226900007752 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 226900007753 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 226900007754 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 226900007755 putative metal binding site [ion binding]; other site 226900007756 putative dimer interface [polypeptide binding]; other site 226900007757 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 226900007758 Transcriptional regulator [Transcription]; Region: IclR; COG1414 226900007759 Bacterial transcriptional regulator; Region: IclR; pfam01614 226900007760 S-methylmethionine transporter; Provisional; Region: PRK11387 226900007761 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900007762 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 226900007763 putative metal binding site [ion binding]; other site 226900007764 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 226900007765 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 226900007766 putative di-iron ligands [ion binding]; other site 226900007767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 226900007768 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 226900007769 VanW like protein; Region: VanW; pfam04294 226900007770 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 226900007771 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 226900007772 dimer interface [polypeptide binding]; other site 226900007773 active site 226900007774 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 226900007775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900007776 salt bridge; other site 226900007777 non-specific DNA binding site [nucleotide binding]; other site 226900007778 sequence-specific DNA binding site [nucleotide binding]; other site 226900007779 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 226900007780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900007781 active site 226900007782 motif I; other site 226900007783 motif II; other site 226900007784 uridine kinase; Provisional; Region: PRK07667 226900007785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007787 Coenzyme A binding pocket [chemical binding]; other site 226900007788 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900007789 active site 226900007790 metal binding site [ion binding]; metal-binding site 226900007791 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 226900007792 Transcriptional regulator PadR-like family; Region: PadR; cl17335 226900007793 MoxR-like ATPases [General function prediction only]; Region: COG0714 226900007794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900007795 Walker A motif; other site 226900007796 ATP binding site [chemical binding]; other site 226900007797 Walker B motif; other site 226900007798 arginine finger; other site 226900007799 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 226900007800 Protein of unknown function DUF58; Region: DUF58; pfam01882 226900007801 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 226900007802 proline/glycine betaine transporter; Provisional; Region: PRK10642 226900007803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900007804 putative substrate translocation pore; other site 226900007805 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007806 active site 226900007807 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007808 active site 226900007809 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226900007810 active site 226900007811 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 226900007812 Ligand binding site; other site 226900007813 Putative Catalytic site; other site 226900007814 DXD motif; other site 226900007815 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 226900007816 active site 226900007817 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007818 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900007819 active site 226900007820 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 226900007821 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900007822 inhibitor-cofactor binding pocket; inhibition site 226900007823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007824 catalytic residue [active] 226900007825 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 226900007826 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 226900007827 tetramer interface [polypeptide binding]; other site 226900007828 heme binding pocket [chemical binding]; other site 226900007829 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 226900007830 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 226900007831 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 226900007832 active site 226900007833 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900007834 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 226900007835 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 226900007836 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 226900007837 Protein of unknown function DUF58; Region: DUF58; pfam01882 226900007838 MoxR-like ATPases [General function prediction only]; Region: COG0714 226900007839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 226900007840 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 226900007841 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 226900007842 LXG domain of WXG superfamily; Region: LXG; pfam04740 226900007843 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 226900007844 Uncharacterized conserved protein [Function unknown]; Region: COG1359 226900007845 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 226900007846 dimer interface [polypeptide binding]; other site 226900007847 FMN binding site [chemical binding]; other site 226900007848 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900007849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900007850 putative DNA binding site [nucleotide binding]; other site 226900007851 putative Zn2+ binding site [ion binding]; other site 226900007852 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 226900007853 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 226900007854 G1 box; other site 226900007855 putative GEF interaction site [polypeptide binding]; other site 226900007856 GTP/Mg2+ binding site [chemical binding]; other site 226900007857 Switch I region; other site 226900007858 G2 box; other site 226900007859 G3 box; other site 226900007860 Switch II region; other site 226900007861 G4 box; other site 226900007862 G5 box; other site 226900007863 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 226900007864 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226900007865 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 226900007866 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 226900007867 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 226900007868 nudix motif; other site 226900007869 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 226900007870 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 226900007871 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 226900007872 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 226900007873 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900007874 putative NAD(P) binding site [chemical binding]; other site 226900007875 active site 226900007876 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 226900007877 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900007878 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900007879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900007880 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 226900007881 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 226900007882 nucleoside/Zn binding site; other site 226900007883 dimer interface [polypeptide binding]; other site 226900007884 catalytic motif [active] 226900007885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900007886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007887 Coenzyme A binding pocket [chemical binding]; other site 226900007888 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 226900007889 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 226900007890 nudix motif; other site 226900007891 EamA-like transporter family; Region: EamA; pfam00892 226900007892 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900007893 EamA-like transporter family; Region: EamA; pfam00892 226900007894 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900007895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900007896 DNA-binding site [nucleotide binding]; DNA binding site 226900007897 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900007898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900007899 homodimer interface [polypeptide binding]; other site 226900007900 catalytic residue [active] 226900007901 hypothetical protein; Validated; Region: PRK00124 226900007902 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 226900007903 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900007904 HAMP domain; Region: HAMP; pfam00672 226900007905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900007906 dimer interface [polypeptide binding]; other site 226900007907 phosphorylation site [posttranslational modification] 226900007908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900007909 ATP binding site [chemical binding]; other site 226900007910 Mg2+ binding site [ion binding]; other site 226900007911 G-X-G motif; other site 226900007912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900007913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900007914 active site 226900007915 phosphorylation site [posttranslational modification] 226900007916 intermolecular recognition site; other site 226900007917 dimerization interface [polypeptide binding]; other site 226900007918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 226900007919 DNA binding site [nucleotide binding] 226900007920 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900007921 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 226900007922 catalytic site [active] 226900007923 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 226900007924 uridine kinase; Validated; Region: PRK06696 226900007925 active site 226900007926 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 226900007927 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226900007928 active site 226900007929 metal binding site [ion binding]; metal-binding site 226900007930 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 226900007931 Phosphotransferase enzyme family; Region: APH; pfam01636 226900007932 active site 226900007933 ATP binding site [chemical binding]; other site 226900007934 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 226900007935 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900007936 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900007937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900007938 Coenzyme A binding pocket [chemical binding]; other site 226900007939 lysine transporter; Provisional; Region: PRK10836 226900007940 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900007941 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 226900007942 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 226900007943 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 226900007944 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 226900007945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900007946 S-adenosylmethionine binding site [chemical binding]; other site 226900007947 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 226900007948 putative active site [active] 226900007949 nucleotide binding site [chemical binding]; other site 226900007950 nudix motif; other site 226900007951 putative metal binding site [ion binding]; other site 226900007952 Cephalosporin hydroxylase; Region: CmcI; pfam04989 226900007953 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900007954 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900007955 Catalytic site [active] 226900007956 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 226900007957 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900007958 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900007959 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900007960 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 226900007961 NAD+ binding site [chemical binding]; other site 226900007962 substrate binding site [chemical binding]; other site 226900007963 Zn binding site [ion binding]; other site 226900007964 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 226900007965 putative substrate binding pocket [chemical binding]; other site 226900007966 AC domain interface; other site 226900007967 catalytic triad [active] 226900007968 AB domain interface; other site 226900007969 interchain disulfide; other site 226900007970 Protein of unknown function (DUF979); Region: DUF979; pfam06166 226900007971 Protein of unknown function (DUF969); Region: DUF969; pfam06149 226900007972 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 226900007973 putative active site [active] 226900007974 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 226900007975 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 226900007976 Transcriptional regulator [Transcription]; Region: IclR; COG1414 226900007977 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 226900007978 Bacterial transcriptional regulator; Region: IclR; pfam01614 226900007979 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900007980 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900007981 Catalytic site [active] 226900007982 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 226900007983 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 226900007984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900007985 dimerization interface [polypeptide binding]; other site 226900007986 putative DNA binding site [nucleotide binding]; other site 226900007987 putative Zn2+ binding site [ion binding]; other site 226900007988 DinB superfamily; Region: DinB_2; pfam12867 226900007989 similar to Acyl-CoA dehydrogenase, short-chain specific; EC_number 1.3.99.2 226900007990 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900007991 putative active site [active] 226900007992 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900007993 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900007994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 226900007995 Nucleoside recognition; Region: Gate; pfam07670 226900007996 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 226900007997 Phosphotransferase enzyme family; Region: APH; pfam01636 226900007998 putative active site [active] 226900007999 putative substrate binding site [chemical binding]; other site 226900008000 ATP binding site [chemical binding]; other site 226900008001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008002 Coenzyme A binding pocket [chemical binding]; other site 226900008003 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 226900008004 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 226900008005 dinuclear metal binding motif [ion binding]; other site 226900008006 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900008007 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900008008 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 226900008009 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 226900008010 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 226900008011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900008012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900008013 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 226900008014 similar to Immune inhibitor A precursor; EC_number 3.4.24.- 226900008015 phosphoenolpyruvate synthase; Validated; Region: PRK06241 226900008016 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 226900008017 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 226900008018 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900008019 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 226900008020 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 226900008021 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900008022 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 226900008023 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 226900008024 NAD binding site [chemical binding]; other site 226900008025 catalytic Zn binding site [ion binding]; other site 226900008026 structural Zn binding site [ion binding]; other site 226900008027 aspartate ammonia-lyase; Provisional; Region: PRK14515 226900008028 Aspartase; Region: Aspartase; cd01357 226900008029 active sites [active] 226900008030 tetramer interface [polypeptide binding]; other site 226900008031 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 226900008032 active site 226900008033 homodimer interface [polypeptide binding]; other site 226900008034 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900008035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900008036 non-specific DNA binding site [nucleotide binding]; other site 226900008037 salt bridge; other site 226900008038 sequence-specific DNA binding site [nucleotide binding]; other site 226900008039 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 226900008040 Spore germination protein; Region: Spore_permease; cl17796 226900008041 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900008042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008043 PAS domain S-box; Region: sensory_box; TIGR00229 226900008044 PAS domain S-box; Region: sensory_box; TIGR00229 226900008045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900008046 putative active site [active] 226900008047 heme pocket [chemical binding]; other site 226900008048 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226900008049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900008050 putative active site [active] 226900008051 heme pocket [chemical binding]; other site 226900008052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900008053 dimer interface [polypeptide binding]; other site 226900008054 phosphorylation site [posttranslational modification] 226900008055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008056 ATP binding site [chemical binding]; other site 226900008057 Mg2+ binding site [ion binding]; other site 226900008058 G-X-G motif; other site 226900008059 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900008060 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900008061 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900008062 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 226900008063 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 226900008064 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 226900008065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900008066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900008067 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900008068 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 226900008069 GIY-YIG motif/motif A; other site 226900008070 active site 226900008071 catalytic site [active] 226900008072 metal binding site [ion binding]; metal-binding site 226900008073 amino acid transporter; Region: 2A0306; TIGR00909 226900008074 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900008075 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 226900008076 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 226900008077 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 226900008078 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 226900008079 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 226900008080 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900008081 Spore germination protein; Region: Spore_permease; pfam03845 226900008082 similar to Spore germination protein BA 226900008083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900008084 active site 226900008085 phosphorylation site [posttranslational modification] 226900008086 intermolecular recognition site; other site 226900008087 dimerization interface [polypeptide binding]; other site 226900008088 YcbB domain; Region: YcbB; pfam08664 226900008089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900008090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008091 ATP binding site [chemical binding]; other site 226900008092 Mg2+ binding site [ion binding]; other site 226900008093 G-X-G motif; other site 226900008094 glutaminase; Reviewed; Region: PRK12357 226900008095 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 226900008096 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 226900008097 transmembrane helices; other site 226900008098 Cytochrome P450; Region: p450; cl12078 226900008099 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900008100 Erythromycin esterase; Region: Erythro_esteras; pfam05139 226900008101 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226900008102 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 226900008103 putative active site [active] 226900008104 putative metal binding site [ion binding]; other site 226900008105 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226900008106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 226900008107 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900008108 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 226900008109 catalytic triad [active] 226900008110 dimer interface [polypeptide binding]; other site 226900008111 conserved cis-peptide bond; other site 226900008112 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 226900008113 catalytic triad [active] 226900008114 dimer interface [polypeptide binding]; other site 226900008115 conserved cis-peptide bond; other site 226900008116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 226900008117 similar to Exoenzymes regulatory protein aepA precursor 226900008118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900008119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900008120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900008121 dimerization interface [polypeptide binding]; other site 226900008122 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900008123 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900008124 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 226900008125 Cl binding site [ion binding]; other site 226900008126 oligomer interface [polypeptide binding]; other site 226900008127 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 226900008128 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 226900008129 Mg binding site [ion binding]; other site 226900008130 nucleotide binding site [chemical binding]; other site 226900008131 putative protofilament interface [polypeptide binding]; other site 226900008132 Heat induced stress protein YflT; Region: YflT; pfam11181 226900008133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900008134 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 226900008135 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 226900008136 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226900008137 TspO/MBR family; Region: TspO_MBR; pfam03073 226900008138 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 226900008139 DNA photolyase; Region: DNA_photolyase; pfam00875 226900008140 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 226900008141 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 226900008142 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 226900008143 FAD dependent oxidoreductase; Region: DAO; pfam01266 226900008144 Carbonic anhydrase; Region: Pro_CA; pfam00484 226900008145 zinc binding site [ion binding]; other site 226900008146 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; cl19828 226900008147 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 226900008148 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 226900008149 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 226900008150 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 226900008151 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226900008152 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 226900008153 NodB motif; other site 226900008154 active site 226900008155 catalytic site [active] 226900008156 Zn binding site [ion binding]; other site 226900008157 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900008158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008159 Coenzyme A binding pocket [chemical binding]; other site 226900008160 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 226900008161 putative active site [active] 226900008162 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 226900008163 DJ-1 family protein; Region: not_thiJ; TIGR01383 226900008164 conserved cys residue [active] 226900008165 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 226900008166 Low molecular weight phosphatase family; Region: LMWPc; cd00115 226900008167 active site 226900008168 arsenical-resistance protein; Region: acr3; TIGR00832 226900008169 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 226900008170 putative metal binding site [ion binding]; other site 226900008171 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008172 dimerization interface [polypeptide binding]; other site 226900008173 putative DNA binding site [nucleotide binding]; other site 226900008174 putative Zn2+ binding site [ion binding]; other site 226900008175 DinB superfamily; Region: DinB_2; pfam12867 226900008176 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 226900008177 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 226900008178 Male sterility protein; Region: NAD_binding_4; pfam07993 226900008179 putative NAD(P) binding site [chemical binding]; other site 226900008180 active site 226900008181 putative substrate binding site [chemical binding]; other site 226900008182 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900008183 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900008184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900008185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900008186 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 226900008187 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 226900008188 FOG: PKD repeat [General function prediction only]; Region: COG3291 226900008189 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 226900008190 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900008191 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226900008192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008193 putative substrate translocation pore; other site 226900008194 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900008195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900008196 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 226900008197 Ligand binding site; other site 226900008198 metal-binding site 226900008199 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 226900008200 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 226900008201 XdhC Rossmann domain; Region: XdhC_C; pfam13478 226900008202 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 226900008203 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900008204 catalytic loop [active] 226900008205 iron binding site [ion binding]; other site 226900008206 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 226900008207 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 226900008208 FAD binding domain; Region: FAD_binding_4; cl19922 226900008209 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 226900008210 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 226900008211 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 226900008212 Beta-lactamase; Region: Beta-lactamase; cl17358 226900008213 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900008214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900008215 S-adenosylmethionine binding site [chemical binding]; other site 226900008216 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 226900008217 short chain dehydrogenase; Provisional; Region: PRK12746 226900008218 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 226900008219 NAD(P) binding site [chemical binding]; other site 226900008220 active site 226900008221 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900008222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008223 putative DNA binding site [nucleotide binding]; other site 226900008224 putative Zn2+ binding site [ion binding]; other site 226900008225 AsnC family; Region: AsnC_trans_reg; pfam01037 226900008226 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 226900008227 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900008228 metal binding site [ion binding]; metal-binding site 226900008229 AAA domain; Region: AAA_11; pfam13086 226900008230 Part of AAA domain; Region: AAA_19; pfam13245 226900008231 Erp protein C-terminus; Region: Erp_C; pfam06780 226900008232 AAA domain; Region: AAA_30; pfam13604 226900008233 AAA domain; Region: AAA_12; pfam13087 226900008234 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 226900008235 putative active site [active] 226900008236 catalytic site [active] 226900008237 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900008238 active site 226900008239 metal binding site [ion binding]; metal-binding site 226900008240 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 226900008241 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 226900008242 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900008243 putative active site [active] 226900008244 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 226900008245 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900008246 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900008247 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 226900008248 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 226900008249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900008250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900008251 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900008252 dimerization interface [polypeptide binding]; other site 226900008253 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900008254 EamA-like transporter family; Region: EamA; pfam00892 226900008255 EamA-like transporter family; Region: EamA; pfam00892 226900008256 putative monooxygenase; Provisional; Region: PRK11118 226900008257 DoxX-like family; Region: DoxX_2; pfam13564 226900008258 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900008259 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900008260 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 226900008261 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 226900008262 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900008263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008264 putative substrate translocation pore; other site 226900008265 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 226900008266 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 226900008267 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900008268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900008269 active site 226900008270 phosphorylation site [posttranslational modification] 226900008271 intermolecular recognition site; other site 226900008272 dimerization interface [polypeptide binding]; other site 226900008273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900008274 DNA binding site [nucleotide binding] 226900008275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900008276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900008277 dimerization interface [polypeptide binding]; other site 226900008278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900008279 dimer interface [polypeptide binding]; other site 226900008280 phosphorylation site [posttranslational modification] 226900008281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008282 ATP binding site [chemical binding]; other site 226900008283 Mg2+ binding site [ion binding]; other site 226900008284 G-X-G motif; other site 226900008285 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 226900008286 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 226900008287 Erythromycin esterase; Region: Erythro_esteras; pfam05139 226900008288 Putative sensor; Region: Sensor; pfam13796 226900008289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900008290 Histidine kinase; Region: HisKA_3; pfam07730 226900008291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008292 ATP binding site [chemical binding]; other site 226900008293 Mg2+ binding site [ion binding]; other site 226900008294 G-X-G motif; other site 226900008295 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900008296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900008297 active site 226900008298 phosphorylation site [posttranslational modification] 226900008299 intermolecular recognition site; other site 226900008300 dimerization interface [polypeptide binding]; other site 226900008301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900008302 DNA binding residues [nucleotide binding] 226900008303 dimerization interface [polypeptide binding]; other site 226900008304 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 226900008305 putative metal binding site [ion binding]; other site 226900008306 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 226900008307 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 226900008308 Flavodoxin; Region: Flavodoxin_1; pfam00258 226900008309 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 226900008310 FAD binding pocket [chemical binding]; other site 226900008311 FAD binding motif [chemical binding]; other site 226900008312 catalytic residues [active] 226900008313 NAD binding pocket [chemical binding]; other site 226900008314 phosphate binding motif [ion binding]; other site 226900008315 beta-alpha-beta structure motif; other site 226900008316 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900008317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008318 putative substrate translocation pore; other site 226900008319 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 226900008320 D-cysteine desulfhydrase; Validated; Region: PRK03910 226900008321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900008322 catalytic residue [active] 226900008323 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226900008324 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 226900008325 active site 226900008326 metal binding site [ion binding]; metal-binding site 226900008327 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 226900008328 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900008329 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 226900008330 AAA domain; Region: AAA_33; pfam13671 226900008331 AAA domain; Region: AAA_17; pfam13207 226900008332 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 226900008333 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 226900008334 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 226900008335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900008336 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900008337 Walker A/P-loop; other site 226900008338 ATP binding site [chemical binding]; other site 226900008339 Q-loop/lid; other site 226900008340 ABC transporter signature motif; other site 226900008341 Walker B; other site 226900008342 D-loop; other site 226900008343 H-loop/switch region; other site 226900008344 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226900008345 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900008346 FtsX-like permease family; Region: FtsX; pfam02687 226900008347 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008348 dimerization interface [polypeptide binding]; other site 226900008349 putative DNA binding site [nucleotide binding]; other site 226900008350 Predicted transcriptional regulator [Transcription]; Region: COG2345 226900008351 putative Zn2+ binding site [ion binding]; other site 226900008352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008353 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900008354 putative substrate translocation pore; other site 226900008355 DinB superfamily; Region: DinB_2; pfam12867 226900008356 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 226900008357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900008358 dimerization interface [polypeptide binding]; other site 226900008359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900008360 dimer interface [polypeptide binding]; other site 226900008361 phosphorylation site [posttranslational modification] 226900008362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008363 ATP binding site [chemical binding]; other site 226900008364 Mg2+ binding site [ion binding]; other site 226900008365 G-X-G motif; other site 226900008366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900008367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900008368 active site 226900008369 phosphorylation site [posttranslational modification] 226900008370 intermolecular recognition site; other site 226900008371 dimerization interface [polypeptide binding]; other site 226900008372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900008373 DNA binding site [nucleotide binding] 226900008374 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900008375 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900008376 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226900008377 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 226900008378 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 226900008379 putative dimer interface [polypeptide binding]; other site 226900008380 catalytic triad [active] 226900008381 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 226900008382 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 226900008383 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 226900008384 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 226900008385 Putative toxin 54; Region: Toxin_54; pfam15533 226900008386 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 226900008387 active site 226900008388 catalytic residues [active] 226900008389 Acylphosphatase; Region: Acylphosphatase; pfam00708 226900008390 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 226900008391 HypF finger; Region: zf-HYPF; pfam07503 226900008392 HypF finger; Region: zf-HYPF; pfam07503 226900008393 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 226900008394 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 226900008395 dimerization interface [polypeptide binding]; other site 226900008396 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 226900008397 ATP binding site [chemical binding]; other site 226900008398 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 226900008399 catalytic triad [active] 226900008400 conserved cis-peptide bond; other site 226900008401 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900008402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008403 putative DNA binding site [nucleotide binding]; other site 226900008404 putative Zn2+ binding site [ion binding]; other site 226900008405 AsnC family; Region: AsnC_trans_reg; pfam01037 226900008406 putative transporter; Provisional; Region: PRK11021 226900008407 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900008408 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 226900008409 similar to hypothetical Cytosolic Protein 226900008410 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 226900008411 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 226900008412 putative ligand binding site [chemical binding]; other site 226900008413 putative NAD binding site [chemical binding]; other site 226900008414 putative catalytic site [active] 226900008415 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 226900008416 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 226900008417 homodimer interface [polypeptide binding]; other site 226900008418 substrate-cofactor binding pocket; other site 226900008419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900008420 catalytic residue [active] 226900008421 Domain of unknown function (DUF378); Region: DUF378; cl00943 226900008422 Cupin domain; Region: Cupin_2; cl17218 226900008423 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 226900008424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900008425 Penicillin amidase; Region: Penicil_amidase; pfam01804 226900008426 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 226900008427 active site 226900008428 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 226900008429 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 226900008430 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900008431 amidase catalytic site [active] 226900008432 Zn binding residues [ion binding]; other site 226900008433 substrate binding site [chemical binding]; other site 226900008434 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900008435 S-layer homology domain; Region: SLH; pfam00395 226900008436 S-layer homology domain; Region: SLH; pfam00395 226900008437 S-layer homology domain; Region: SLH; pfam00395 226900008438 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 226900008439 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 226900008440 Protein of unknown function, DUF600; Region: DUF600; pfam04634 226900008441 A new structural DNA glycosylase; Region: AlkD_like; cd06561 226900008442 active site 226900008443 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 226900008444 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 226900008445 Syd protein (SUKH-2); Region: Syd; pfam07348 226900008446 similar to hypothetical protein 226900008447 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 226900008448 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 226900008449 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 226900008450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 226900008451 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 226900008452 nucleophilic elbow; other site 226900008453 catalytic triad; other site 226900008454 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 226900008455 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 226900008456 Immunity protein Imm3; Region: Imm3; pfam14425 226900008457 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 226900008458 Immunity protein 16; Region: Imm16; pfam15565 226900008459 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 226900008460 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 226900008461 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 226900008462 Protein of unknown function, DUF600; Region: DUF600; pfam04634 226900008463 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 226900008464 Nuclease N terminal; Region: Nuc_N; pfam14448 226900008465 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 226900008466 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 226900008467 Nuclease N terminal; Region: Nuc_N; pfam14448 226900008468 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 226900008469 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 226900008470 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 226900008471 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 226900008472 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 226900008473 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 226900008474 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 226900008475 putative active site [active] 226900008476 putative metal binding site [ion binding]; other site 226900008477 NETI protein; Region: NETI; pfam14044 226900008478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900008480 putative substrate translocation pore; other site 226900008481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 226900008482 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900008483 TAP-like protein; Region: Abhydrolase_4; pfam08386 226900008484 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900008485 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900008486 putative DNA binding site [nucleotide binding]; other site 226900008487 putative Zn2+ binding site [ion binding]; other site 226900008488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900008490 putative substrate translocation pore; other site 226900008491 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900008492 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 226900008493 putative deacylase active site [active] 226900008494 histidyl-tRNA synthetase; Provisional; Region: PRK12420 226900008495 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 226900008496 dimer interface [polypeptide binding]; other site 226900008497 motif 1; other site 226900008498 active site 226900008499 motif 2; other site 226900008500 motif 3; other site 226900008501 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 226900008502 anticodon binding site; other site 226900008503 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 226900008504 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 226900008505 dimer interface [polypeptide binding]; other site 226900008506 FMN binding site [chemical binding]; other site 226900008507 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 226900008508 pyruvate kinase; Validated; Region: PRK06739 226900008509 protein kinase; Provisional; Region: PTZ00284 226900008510 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 226900008511 classical (c) SDRs; Region: SDR_c; cd05233 226900008512 NAD(P) binding site [chemical binding]; other site 226900008513 active site 226900008514 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226900008515 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900008516 Walker A/P-loop; other site 226900008517 ATP binding site [chemical binding]; other site 226900008518 Q-loop/lid; other site 226900008519 ABC transporter signature motif; other site 226900008520 Walker B; other site 226900008521 D-loop; other site 226900008522 H-loop/switch region; other site 226900008523 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 226900008524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900008525 non-specific DNA binding site [nucleotide binding]; other site 226900008526 salt bridge; other site 226900008527 sequence-specific DNA binding site [nucleotide binding]; other site 226900008528 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 226900008529 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 226900008530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900008531 motif II; other site 226900008532 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 226900008533 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 226900008534 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 226900008535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008536 Coenzyme A binding pocket [chemical binding]; other site 226900008537 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 226900008538 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 226900008539 nudix motif; other site 226900008540 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 226900008541 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 226900008542 active site 226900008543 HIGH motif; other site 226900008544 dimer interface [polypeptide binding]; other site 226900008545 KMSKS motif; other site 226900008546 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 226900008547 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 226900008548 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 226900008549 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 226900008550 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226900008551 Predicted membrane protein [Function unknown]; Region: COG2261 226900008552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008553 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900008554 Coenzyme A binding pocket [chemical binding]; other site 226900008555 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008556 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008557 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008558 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008559 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008560 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008561 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008562 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008563 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008564 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008565 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008566 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008567 High molecular weight glutenin subunit; Region: Glutenin_hmw; pfam03157 226900008568 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008569 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900008570 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900008571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900008572 S-adenosylmethionine binding site [chemical binding]; other site 226900008573 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 226900008574 CGNR zinc finger; Region: zf-CGNR; pfam11706 226900008575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008576 multidrug resistance protein MdtH; Provisional; Region: PRK11646 226900008577 putative substrate translocation pore; other site 226900008578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900008579 TPR motif; other site 226900008580 TPR repeat; Region: TPR_11; pfam13414 226900008581 binding surface 226900008582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900008583 binding surface 226900008584 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226900008585 TPR motif; other site 226900008586 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 226900008587 hypothetical protein; Provisional; Region: PRK04164 226900008588 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 226900008589 ATP synthase I chain; Region: ATP_synt_I; pfam03899 226900008590 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 226900008591 Domain of unknown function DUF21; Region: DUF21; pfam01595 226900008592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 226900008593 Transporter associated domain; Region: CorC_HlyC; smart01091 226900008594 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 226900008595 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900008596 DNA binding residues [nucleotide binding] 226900008597 putative dimer interface [polypeptide binding]; other site 226900008598 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 226900008599 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 226900008600 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 226900008601 substrate binding site; other site 226900008602 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 226900008603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008604 NAD(P) binding site [chemical binding]; other site 226900008605 active site 226900008606 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 226900008607 Methyltransferase domain; Region: Methyltransf_23; pfam13489 226900008608 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 226900008609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008610 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900008611 NAD(P) binding site [chemical binding]; other site 226900008612 active site 226900008613 Variant SH3 domain; Region: SH3_2; pfam07653 226900008614 peptide ligand binding site [polypeptide binding]; other site 226900008615 Src Homology 3 domain superfamily; Region: SH3; cl17036 226900008616 peptide ligand binding site [polypeptide binding]; other site 226900008617 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900008618 EamA-like transporter family; Region: EamA; pfam00892 226900008619 EamA-like transporter family; Region: EamA; pfam00892 226900008620 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 226900008621 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 226900008622 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 226900008623 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 226900008624 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 226900008625 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 226900008626 N- and C-terminal domain interface [polypeptide binding]; other site 226900008627 active site 226900008628 catalytic site [active] 226900008629 metal binding site [ion binding]; metal-binding site 226900008630 carbohydrate binding site [chemical binding]; other site 226900008631 ATP binding site [chemical binding]; other site 226900008632 GntP family permease; Region: GntP_permease; pfam02447 226900008633 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226900008634 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 226900008635 active site 226900008636 intersubunit interactions; other site 226900008637 catalytic residue [active] 226900008638 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 226900008639 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 226900008640 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 226900008641 similar to Transketolase; EC_number 2.2.1.1 226900008642 similar to Glucose-6-phosphate 1-dehydrogenase; EC_number 1.1.1.49 226900008643 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900008644 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 226900008645 putative NAD(P) binding site [chemical binding]; other site 226900008646 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 226900008647 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 226900008648 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900008649 putative NAD(P) binding site [chemical binding]; other site 226900008650 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 226900008651 classical (c) SDRs; Region: SDR_c; cd05233 226900008652 NAD(P) binding site [chemical binding]; other site 226900008653 active site 226900008654 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900008655 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900008656 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900008657 active site 226900008658 Zn binding site [ion binding]; other site 226900008659 Peptidase M60-like family; Region: M60-like; cl19940 226900008660 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 226900008661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900008662 dimerization interface [polypeptide binding]; other site 226900008663 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900008664 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 226900008665 dimer interface [polypeptide binding]; other site 226900008666 putative CheW interface [polypeptide binding]; other site 226900008667 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 226900008668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900008669 motif II; other site 226900008670 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 226900008671 catalytic motif [active] 226900008672 Zn binding site [ion binding]; other site 226900008673 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 226900008674 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 226900008675 dimerization interface [polypeptide binding]; other site 226900008676 active site 226900008677 Predicted transcriptional regulators [Transcription]; Region: COG1733 226900008678 dimerization interface [polypeptide binding]; other site 226900008679 putative DNA binding site [nucleotide binding]; other site 226900008680 putative Zn2+ binding site [ion binding]; other site 226900008681 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 226900008682 dimer interface [polypeptide binding]; other site 226900008683 FMN binding site [chemical binding]; other site 226900008684 BNR repeat-like domain; Region: BNR_2; pfam13088 226900008685 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900008686 active site 226900008687 catalytic tetrad [active] 226900008688 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226900008689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008690 putative substrate translocation pore; other site 226900008691 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 226900008692 active site 1 [active] 226900008693 dimer interface [polypeptide binding]; other site 226900008694 hexamer interface [polypeptide binding]; other site 226900008695 active site 2 [active] 226900008696 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 226900008697 hexamer interface [polypeptide binding]; other site 226900008698 active site 2 [active] 226900008699 hypothetical protein; Provisional; Region: PRK02487 226900008700 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 226900008701 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 226900008702 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 226900008703 IDEAL domain; Region: IDEAL; pfam08858 226900008704 Predicted transcriptional regulator [Transcription]; Region: COG1959 226900008705 Rrf2 family protein; Region: rrf2_super; TIGR00738 226900008706 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 226900008707 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 226900008708 putative catalytic residues [active] 226900008709 thiol/disulfide switch; other site 226900008710 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008711 dimerization interface [polypeptide binding]; other site 226900008712 putative DNA binding site [nucleotide binding]; other site 226900008713 putative Zn2+ binding site [ion binding]; other site 226900008714 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226900008715 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 226900008716 putative oxidoreductase; Provisional; Region: PRK10206 226900008717 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226900008718 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 226900008719 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 226900008720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900008721 S-adenosylmethionine binding site [chemical binding]; other site 226900008722 Predicted transcriptional regulators [Transcription]; Region: COG1733 226900008723 dimerization interface [polypeptide binding]; other site 226900008724 putative DNA binding site [nucleotide binding]; other site 226900008725 putative Zn2+ binding site [ion binding]; other site 226900008726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008727 dimerization interface [polypeptide binding]; other site 226900008728 putative DNA binding site [nucleotide binding]; other site 226900008729 putative Zn2+ binding site [ion binding]; other site 226900008730 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900008731 active site 226900008732 catalytic tetrad [active] 226900008733 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 226900008734 putative hydrophobic ligand binding site [chemical binding]; other site 226900008735 protein interface [polypeptide binding]; other site 226900008736 gate; other site 226900008737 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 226900008738 putative active site [active] 226900008739 putative catalytic triad [active] 226900008740 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 226900008741 catalytic triad [active] 226900008742 oxyanion hole [active] 226900008743 active site 226900008744 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900008745 Phosphotransferase enzyme family; Region: APH; pfam01636 226900008746 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 226900008747 active site 226900008748 substrate binding site [chemical binding]; other site 226900008749 ATP binding site [chemical binding]; other site 226900008750 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 226900008751 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 226900008752 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 226900008753 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 226900008754 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226900008755 acyl-activating enzyme (AAE) consensus motif; other site 226900008756 AMP binding site [chemical binding]; other site 226900008757 active site 226900008758 CoA binding site [chemical binding]; other site 226900008759 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 226900008760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008761 dimerization interface [polypeptide binding]; other site 226900008762 putative DNA binding site [nucleotide binding]; other site 226900008763 putative Zn2+ binding site [ion binding]; other site 226900008764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008765 dimerization interface [polypeptide binding]; other site 226900008766 putative DNA binding site [nucleotide binding]; other site 226900008767 putative Zn2+ binding site [ion binding]; other site 226900008768 similar to Glycosyltransferase; EC_number 2.4.1.- 226900008769 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 226900008770 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 226900008771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900008772 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900008773 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 226900008774 active site 226900008775 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 226900008776 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 226900008777 VPS10 domain; Region: VPS10; smart00602 226900008778 LysE type translocator; Region: LysE; cl00565 226900008779 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 226900008780 Integron-associated effector binding protein; Region: Cass2; pfam14526 226900008781 Predicted transcriptional regulator [Transcription]; Region: COG2378 226900008782 HTH domain; Region: HTH_11; pfam08279 226900008783 WYL domain; Region: WYL; pfam13280 226900008784 ABC-2 type transporter; Region: ABC2_membrane; cl17235 226900008785 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 226900008786 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 226900008787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900008788 Walker A/P-loop; other site 226900008789 ATP binding site [chemical binding]; other site 226900008790 Q-loop/lid; other site 226900008791 ABC transporter signature motif; other site 226900008792 Walker B; other site 226900008793 D-loop; other site 226900008794 H-loop/switch region; other site 226900008795 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 226900008796 Predicted transcriptional regulators [Transcription]; Region: COG1695 226900008797 hydroxylamine reductase; Provisional; Region: PRK12310 226900008798 ACS interaction site; other site 226900008799 CODH interaction site; other site 226900008800 metal cluster binding site [ion binding]; other site 226900008801 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900008802 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 226900008803 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900008804 active site 226900008805 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 226900008806 metal binding site [ion binding]; metal-binding site 226900008807 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 226900008808 hypothetical protein; Provisional; Region: PRK06771 226900008809 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 226900008810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 226900008811 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 226900008812 dimer interface [polypeptide binding]; other site 226900008813 ligand binding site [chemical binding]; other site 226900008814 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 226900008815 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900008816 ligand binding site [chemical binding]; other site 226900008817 flexible hinge region; other site 226900008818 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 226900008819 Protein of unknown function, DUF606; Region: DUF606; pfam04657 226900008820 Protein of unknown function, DUF606; Region: DUF606; pfam04657 226900008821 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900008822 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 226900008823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008824 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 226900008825 putative substrate translocation pore; other site 226900008826 Haemolysin XhlA; Region: XhlA; pfam10779 226900008827 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 226900008828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008829 NAD(P) binding site [chemical binding]; other site 226900008830 active site 226900008831 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 226900008832 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 226900008833 Citrate transporter; Region: CitMHS; pfam03600 226900008834 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 226900008835 transmembrane helices; other site 226900008836 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226900008837 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900008838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008839 Coenzyme A binding pocket [chemical binding]; other site 226900008840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900008841 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900008842 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 226900008843 putative ligand binding residues [chemical binding]; other site 226900008844 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900008845 ABC-ATPase subunit interface; other site 226900008846 dimer interface [polypeptide binding]; other site 226900008847 putative PBP binding regions; other site 226900008848 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900008849 ABC-ATPase subunit interface; other site 226900008850 dimer interface [polypeptide binding]; other site 226900008851 putative PBP binding regions; other site 226900008852 Protein of unknown function (DUF817); Region: DUF817; pfam05675 226900008853 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 226900008854 DinB superfamily; Region: DinB_2; pfam12867 226900008855 DinB family; Region: DinB; cl17821 226900008856 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900008857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900008858 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 226900008859 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 226900008860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900008861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900008862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900008863 dimerization interface [polypeptide binding]; other site 226900008864 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900008865 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 226900008866 NADP binding site [chemical binding]; other site 226900008867 dimer interface [polypeptide binding]; other site 226900008868 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900008869 catalytic core [active] 226900008870 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900008871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900008872 Coenzyme A binding pocket [chemical binding]; other site 226900008873 MutS domain III; Region: MutS_III; pfam05192 226900008874 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 226900008875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900008876 Walker A/P-loop; other site 226900008877 ATP binding site [chemical binding]; other site 226900008878 Q-loop/lid; other site 226900008879 ABC transporter signature motif; other site 226900008880 Walker B; other site 226900008881 D-loop; other site 226900008882 H-loop/switch region; other site 226900008883 exosporium leader peptide; Region: exospor_lead; TIGR03720 226900008884 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 226900008885 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 226900008886 active site 226900008887 Na/Ca binding site [ion binding]; other site 226900008888 catalytic site [active] 226900008889 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 226900008890 N-acetyltransferase; Region: Acetyltransf_2; cl00949 226900008891 oligoendopeptidase F; Region: pepF; TIGR00181 226900008892 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 226900008893 active site 226900008894 Zn binding site [ion binding]; other site 226900008895 Amidinotransferase; Region: Amidinotransf; cl19186 226900008896 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 226900008897 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900008898 DNA binding residues [nucleotide binding] 226900008899 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 226900008900 Amidinotransferase; Region: Amidinotransf; cl19186 226900008901 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 226900008902 Amidinotransferase; Region: Amidinotransf; cl19186 226900008903 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900008904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900008905 putative substrate translocation pore; other site 226900008906 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900008907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900008908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900008909 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 226900008910 putative dimerization interface [polypeptide binding]; other site 226900008911 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 226900008912 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 226900008913 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226900008914 active site 226900008915 catalytic site [active] 226900008916 metal binding site [ion binding]; metal-binding site 226900008917 similar to Tetracenomycin polyketide synthesis hydroxylase tcmG; EC_number 1.14.13.- 226900008918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900008919 dimerization interface [polypeptide binding]; other site 226900008920 putative DNA binding site [nucleotide binding]; other site 226900008921 putative Zn2+ binding site [ion binding]; other site 226900008922 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 226900008923 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 226900008924 putative NAD(P) binding site [chemical binding]; other site 226900008925 hypothetical protein; Validated; Region: PRK00029 226900008926 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 226900008927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900008928 TPR motif; other site 226900008929 binding surface 226900008930 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 226900008931 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 226900008932 Sodium Bile acid symporter family; Region: SBF; cl19217 226900008933 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 226900008934 FAD binding domain; Region: FAD_binding_4; pfam01565 226900008935 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 226900008936 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 226900008937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900008938 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900008939 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 226900008940 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 226900008941 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 226900008942 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900008943 active site residue [active] 226900008944 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 226900008945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900008946 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 226900008947 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 226900008948 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900008949 active site 226900008950 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900008951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900008952 NAD(P) binding site [chemical binding]; other site 226900008953 active site 226900008954 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 226900008955 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 226900008956 NAD binding site [chemical binding]; other site 226900008957 homotetramer interface [polypeptide binding]; other site 226900008958 homodimer interface [polypeptide binding]; other site 226900008959 substrate binding site [chemical binding]; other site 226900008960 active site 226900008961 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900008962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900008963 TPR motif; other site 226900008964 binding surface 226900008965 Tar ligand binding domain homologue; Region: TarH; pfam02203 226900008966 Cache domain; Region: Cache_1; pfam02743 226900008967 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900008968 dimerization interface [polypeptide binding]; other site 226900008969 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900008970 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 226900008971 dimer interface [polypeptide binding]; other site 226900008972 putative CheW interface [polypeptide binding]; other site 226900008973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900008974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900008975 beta-channel forming cytolysin; Region: hlyII; TIGR01002 226900008976 S-layer homology domain; Region: SLH; pfam00395 226900008977 S-layer homology domain; Region: SLH; pfam00395 226900008978 S-layer homology domain; Region: SLH; pfam00395 226900008979 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 226900008980 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900008981 active site 226900008982 metal binding site [ion binding]; metal-binding site 226900008983 TQXA domain; Region: TQXA_dom; TIGR03934 226900008984 Cna protein B-type domain; Region: Cna_B; pfam05738 226900008985 Cna protein B-type domain; Region: Cna_B; pfam05738 226900008986 Cna protein B-type domain; Region: Cna_B; pfam05738 226900008987 Cna protein B-type domain; Region: Cna_B; pfam05738 226900008988 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 226900008989 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 226900008990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900008991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900008992 dimer interface [polypeptide binding]; other site 226900008993 phosphorylation site [posttranslational modification] 226900008994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900008995 ATP binding site [chemical binding]; other site 226900008996 G-X-G motif; other site 226900008997 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 226900008998 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 226900008999 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 226900009000 FOG: PKD repeat [General function prediction only]; Region: COG3291 226900009001 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900009002 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 226900009003 MgtC family; Region: MgtC; pfam02308 226900009004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900009005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900009006 Coenzyme A binding pocket [chemical binding]; other site 226900009007 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 226900009008 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 226900009009 putative metal binding site [ion binding]; other site 226900009010 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900009011 active site 226900009012 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 226900009013 VanW like protein; Region: VanW; pfam04294 226900009014 Sensor protein DegS; Region: DegS; pfam05384 226900009015 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 226900009016 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 226900009017 exonuclease; Provisional; Region: PRK06722 226900009018 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 226900009019 active site 226900009020 catalytic site [active] 226900009021 substrate binding site [chemical binding]; other site 226900009022 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226900009023 DNA-binding site [nucleotide binding]; DNA binding site 226900009024 RNA-binding motif; other site 226900009025 flavodoxin; Provisional; Region: PRK06703 226900009026 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 226900009027 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 226900009028 nudix motif; other site 226900009029 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 226900009030 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 226900009031 trimer interface [polypeptide binding]; other site 226900009032 active site 226900009033 substrate binding site [chemical binding]; other site 226900009034 CoA binding site [chemical binding]; other site 226900009035 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009036 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009037 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009038 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009039 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009040 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009041 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009042 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009043 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009044 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009045 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009046 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009047 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009048 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009049 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009050 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900009051 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 226900009052 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 226900009053 NADP binding site [chemical binding]; other site 226900009054 homodimer interface [polypeptide binding]; other site 226900009055 active site 226900009056 Predicted acetyltransferase [General function prediction only]; Region: COG3393 226900009057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900009058 Coenzyme A binding pocket [chemical binding]; other site 226900009059 argininosuccinate lyase; Provisional; Region: PRK06705 226900009060 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 226900009061 active sites [active] 226900009062 tetramer interface [polypeptide binding]; other site 226900009063 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900009064 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900009065 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 226900009066 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 226900009067 active site 226900009068 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 226900009069 Na binding site [ion binding]; other site 226900009070 Protein of unknown function (DUF997); Region: DUF997; pfam06196 226900009071 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 226900009072 NAD(P) binding site [chemical binding]; other site 226900009073 catalytic residues [active] 226900009074 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 226900009075 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 226900009076 NAD(P) binding site [chemical binding]; other site 226900009077 homotetramer interface [polypeptide binding]; other site 226900009078 homodimer interface [polypeptide binding]; other site 226900009079 active site 226900009080 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 226900009081 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 226900009082 Divergent PAP2 family; Region: DUF212; pfam02681 226900009083 Predicted permeases [General function prediction only]; Region: RarD; COG2962 226900009084 EamA-like transporter family; Region: EamA; pfam00892 226900009085 EamA-like transporter family; Region: EamA; pfam00892 226900009086 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 226900009087 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 226900009088 Domain of unknown function DUF59; Region: DUF59; pfam01883 226900009089 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 226900009090 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 226900009091 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 226900009092 Walker A motif; other site 226900009093 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 226900009094 MoaE interaction surface [polypeptide binding]; other site 226900009095 MoeB interaction surface [polypeptide binding]; other site 226900009096 thiocarboxylated glycine; other site 226900009097 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 226900009098 MoaE homodimer interface [polypeptide binding]; other site 226900009099 MoaD interaction [polypeptide binding]; other site 226900009100 active site residues [active] 226900009101 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 226900009102 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 226900009103 dimer interface [polypeptide binding]; other site 226900009104 putative functional site; other site 226900009105 putative MPT binding site; other site 226900009106 similar to Molybdopterin biosynthesis MoeB protein 226900009107 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 226900009108 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 226900009109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900009110 FeS/SAM binding site; other site 226900009111 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 226900009112 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 226900009113 Uncharacterized conserved protein [Function unknown]; Region: COG5609 226900009114 Uncharacterized conserved protein [Function unknown]; Region: COG2427 226900009115 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 226900009116 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 226900009117 catalytic loop [active] 226900009118 iron binding site [ion binding]; other site 226900009119 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 226900009120 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226900009121 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 226900009122 [4Fe-4S] binding site [ion binding]; other site 226900009123 molybdopterin cofactor binding site; other site 226900009124 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 226900009125 molybdopterin cofactor binding site; other site 226900009126 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900009127 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 226900009128 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 226900009129 amino acid transporter; Region: 2A0306; TIGR00909 226900009130 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900009131 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 226900009132 Tubulin like; Region: Tubulin_2; pfam13809 226900009133 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 226900009134 metal ion-dependent adhesion site (MIDAS); other site 226900009135 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900009136 active site 226900009137 metal binding site [ion binding]; metal-binding site 226900009138 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900009139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900009140 S-adenosylmethionine binding site [chemical binding]; other site 226900009141 O-methyltransferase; Region: Methyltransf_2; pfam00891 226900009142 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900009143 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900009144 peptide binding site [polypeptide binding]; other site 226900009145 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900009146 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900009147 peptide binding site [polypeptide binding]; other site 226900009148 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 226900009149 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 226900009150 peptide binding site [polypeptide binding]; other site 226900009151 Transcriptional regulator [Transcription]; Region: LytR; COG1316 226900009152 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 226900009153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900009154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900009155 DNA binding residues [nucleotide binding] 226900009156 Acyltransferase family; Region: Acyl_transf_3; cl19154 226900009157 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900009158 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900009159 Walker A/P-loop; other site 226900009160 ATP binding site [chemical binding]; other site 226900009161 Q-loop/lid; other site 226900009162 ABC transporter signature motif; other site 226900009163 Walker B; other site 226900009164 D-loop; other site 226900009165 H-loop/switch region; other site 226900009166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900009167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900009168 Predicted transcriptional regulator [Transcription]; Region: COG2378 226900009169 HTH domain; Region: HTH_11; pfam08279 226900009170 WYL domain; Region: WYL; pfam13280 226900009171 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 226900009172 dimer interface [polypeptide binding]; other site 226900009173 putative oxidoreductase; Provisional; Region: PRK11579 226900009174 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226900009175 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 226900009176 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 226900009177 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 226900009178 CAP-like domain; other site 226900009179 active site 226900009180 primary dimer interface [polypeptide binding]; other site 226900009181 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900009182 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900009183 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900009184 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 226900009185 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 226900009186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900009187 ATP binding site [chemical binding]; other site 226900009188 Mg2+ binding site [ion binding]; other site 226900009189 G-X-G motif; other site 226900009190 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 226900009191 anchoring element; other site 226900009192 dimer interface [polypeptide binding]; other site 226900009193 ATP binding site [chemical binding]; other site 226900009194 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 226900009195 active site 226900009196 metal binding site [ion binding]; metal-binding site 226900009197 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 226900009198 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 226900009199 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 226900009200 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 226900009201 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 226900009202 protein binding site [polypeptide binding]; other site 226900009203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900009204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900009205 active site 226900009206 phosphorylation site [posttranslational modification] 226900009207 intermolecular recognition site; other site 226900009208 dimerization interface [polypeptide binding]; other site 226900009209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900009210 DNA binding site [nucleotide binding] 226900009211 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 226900009212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900009213 FeS/SAM binding site; other site 226900009214 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 226900009215 Class III ribonucleotide reductase; Region: RNR_III; cd01675 226900009216 effector binding site; other site 226900009217 active site 226900009218 Zn binding site [ion binding]; other site 226900009219 glycine loop; other site 226900009220 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 226900009221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 226900009222 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 226900009223 active site 226900009224 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 226900009225 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226900009226 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226900009227 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 226900009228 active site 226900009229 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 226900009230 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 226900009231 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 226900009232 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 226900009233 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 226900009234 active site 226900009235 catalytic site [active] 226900009236 substrate binding site [chemical binding]; other site 226900009237 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 226900009238 catalytic residues [active] 226900009239 similar to hypothetical protein 226900009240 similar to Multidrug resistance ABC transporter ATP-binding and permease 226900009241 aconitate hydratase; Validated; Region: PRK09277 226900009242 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 226900009243 substrate binding site [chemical binding]; other site 226900009244 ligand binding site [chemical binding]; other site 226900009245 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 226900009246 substrate binding site [chemical binding]; other site 226900009247 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 226900009248 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226900009249 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 226900009250 NodB motif; other site 226900009251 active site 226900009252 catalytic site [active] 226900009253 metal binding site [ion binding]; metal-binding site 226900009254 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 226900009255 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 226900009256 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 226900009257 putative dimer interface [polypeptide binding]; other site 226900009258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900009259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900009260 putative substrate translocation pore; other site 226900009261 similar to Metal-dependent hydrolase related to alanyl-tRNA synthetase 226900009262 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900009263 nudix motif; other site 226900009264 SAP domain; Region: SAP; pfam02037 226900009265 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 226900009266 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 226900009267 dimer interface [polypeptide binding]; other site 226900009268 active site 226900009269 acyl-CoA synthetase; Validated; Region: PRK07638 226900009270 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226900009271 acyl-activating enzyme (AAE) consensus motif; other site 226900009272 AMP binding site [chemical binding]; other site 226900009273 active site 226900009274 CoA binding site [chemical binding]; other site 226900009275 BioY family; Region: BioY; pfam02632 226900009276 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900009277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900009278 Coenzyme A binding pocket [chemical binding]; other site 226900009279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900009280 Coenzyme A binding pocket [chemical binding]; other site 226900009281 CsbD-like; Region: CsbD; pfam05532 226900009282 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 226900009283 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900009284 amidase catalytic site [active] 226900009285 Zn binding residues [ion binding]; other site 226900009286 substrate binding site [chemical binding]; other site 226900009287 active site 226900009288 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 226900009289 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900009290 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900009291 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226900009292 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 226900009293 dimer interface [polypeptide binding]; other site 226900009294 putative metal binding site [ion binding]; other site 226900009295 PAS domain; Region: PAS_9; pfam13426 226900009296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900009297 putative active site [active] 226900009298 heme pocket [chemical binding]; other site 226900009299 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226900009300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900009301 putative active site [active] 226900009302 heme pocket [chemical binding]; other site 226900009303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900009304 dimer interface [polypeptide binding]; other site 226900009305 phosphorylation site [posttranslational modification] 226900009306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900009307 ATP binding site [chemical binding]; other site 226900009308 Mg2+ binding site [ion binding]; other site 226900009309 G-X-G motif; other site 226900009310 Predicted esterase [General function prediction only]; Region: COG0400 226900009311 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226900009312 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 226900009313 Zn binding site [ion binding]; other site 226900009314 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 226900009315 Zn binding site [ion binding]; other site 226900009316 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 226900009317 Na binding site [ion binding]; other site 226900009318 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 226900009319 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 226900009320 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 226900009321 active site 226900009322 FMN binding site [chemical binding]; other site 226900009323 substrate binding site [chemical binding]; other site 226900009324 3Fe-4S cluster binding site [ion binding]; other site 226900009325 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 226900009326 FMN binding site [chemical binding]; other site 226900009327 active site 226900009328 substrate binding site [chemical binding]; other site 226900009329 catalytic residue [active] 226900009330 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 226900009331 similar to Formiminoglutamase; EC_number 3.5.3.8 226900009332 imidazolonepropionase; Validated; Region: PRK09356 226900009333 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 226900009334 active site 226900009335 urocanate hydratase; Provisional; Region: PRK05414 226900009336 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 226900009337 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 226900009338 active sites [active] 226900009339 tetramer interface [polypeptide binding]; other site 226900009340 anti-terminator HutP; Provisional; Region: hutP; PRK03065 226900009341 hexamer interface [polypeptide binding]; other site 226900009342 RNA binding site [nucleotide binding]; other site 226900009343 Histidine-zinc binding site [chemical binding]; other site 226900009344 DJ-1 family protein; Region: not_thiJ; TIGR01383 226900009345 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 226900009346 conserved cys residue [active] 226900009347 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 226900009348 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 226900009349 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 226900009350 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900009351 EamA-like transporter family; Region: EamA; pfam00892 226900009352 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 226900009353 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900009354 metal binding site [ion binding]; metal-binding site 226900009355 dimer interface [polypeptide binding]; other site 226900009356 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226900009357 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 226900009358 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900009359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900009360 Walker A/P-loop; other site 226900009361 ATP binding site [chemical binding]; other site 226900009362 Q-loop/lid; other site 226900009363 ABC transporter signature motif; other site 226900009364 Walker B; other site 226900009365 D-loop; other site 226900009366 H-loop/switch region; other site 226900009367 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 226900009368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900009369 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 226900009370 putative dimerization interface [polypeptide binding]; other site 226900009371 putative substrate binding pocket [chemical binding]; other site 226900009372 holin-like protein; Validated; Region: PRK01658 226900009373 LrgB-like family; Region: LrgB; cl00596 226900009374 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900009375 nudix motif; other site 226900009376 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 226900009377 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 226900009378 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 226900009379 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 226900009380 active site 226900009381 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900009382 Bacterial SH3 domain; Region: SH3_3; cl17532 226900009383 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900009384 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900009385 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 226900009386 Walker A/P-loop; other site 226900009387 ATP binding site [chemical binding]; other site 226900009388 Q-loop/lid; other site 226900009389 ABC transporter signature motif; other site 226900009390 Walker B; other site 226900009391 D-loop; other site 226900009392 H-loop/switch region; other site 226900009393 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900009394 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 226900009395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900009396 Walker A/P-loop; other site 226900009397 ATP binding site [chemical binding]; other site 226900009398 Q-loop/lid; other site 226900009399 ABC transporter signature motif; other site 226900009400 Walker B; other site 226900009401 D-loop; other site 226900009402 H-loop/switch region; other site 226900009403 hypothetical protein; Provisional; Region: PRK01844 226900009404 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 226900009405 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 226900009406 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 226900009407 TPP-binding site [chemical binding]; other site 226900009408 dimer interface [polypeptide binding]; other site 226900009409 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 226900009410 PYR/PP interface [polypeptide binding]; other site 226900009411 dimer interface [polypeptide binding]; other site 226900009412 TPP binding site [chemical binding]; other site 226900009413 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900009414 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 226900009415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900009416 dimer interface [polypeptide binding]; other site 226900009417 conserved gate region; other site 226900009418 putative PBP binding loops; other site 226900009419 ABC-ATPase subunit interface; other site 226900009420 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 226900009421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900009422 dimer interface [polypeptide binding]; other site 226900009423 conserved gate region; other site 226900009424 putative PBP binding loops; other site 226900009425 ABC-ATPase subunit interface; other site 226900009426 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 226900009427 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 226900009428 Walker A/P-loop; other site 226900009429 ATP binding site [chemical binding]; other site 226900009430 Q-loop/lid; other site 226900009431 ABC transporter signature motif; other site 226900009432 Walker B; other site 226900009433 D-loop; other site 226900009434 H-loop/switch region; other site 226900009435 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 226900009436 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900009437 substrate binding pocket [chemical binding]; other site 226900009438 membrane-bound complex binding site; other site 226900009439 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226900009440 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 226900009441 active site 226900009442 metal binding site [ion binding]; metal-binding site 226900009443 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226900009444 hypothetical protein; Provisional; Region: PRK01546 226900009445 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 226900009446 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 226900009447 catalytic residues [active] 226900009448 catalytic nucleophile [active] 226900009449 LexA repressor; Validated; Region: PRK00215 226900009450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900009451 putative DNA binding site [nucleotide binding]; other site 226900009452 putative Zn2+ binding site [ion binding]; other site 226900009453 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 226900009454 Catalytic site [active] 226900009455 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 226900009456 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 226900009457 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 226900009458 Predicted transcriptional regulators [Transcription]; Region: COG1695 226900009459 Bacteriophage ph6A53; inactive remnant; detected in Bacillus thuringiensis var. israelensis 226900009460 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 226900009461 amidase catalytic site [active] 226900009462 Zn binding residues [ion binding]; other site 226900009463 substrate binding site [chemical binding]; other site 226900009464 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900009465 Haemolysin XhlA; Region: XhlA; pfam10779 226900009466 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226900009467 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900009468 Lysozyme-like; Region: Lysozyme_like; pfam13702 226900009469 catalytic residue [active] 226900009470 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 226900009471 Helix-turn-helix domain; Region: HTH_36; pfam13730 226900009472 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 226900009473 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 226900009474 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 226900009475 ORF6C domain; Region: ORF6C; pfam10552 226900009476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900009477 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 226900009478 non-specific DNA binding site [nucleotide binding]; other site 226900009479 salt bridge; other site 226900009480 sequence-specific DNA binding site [nucleotide binding]; other site 226900009481 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 226900009482 Catalytic site [active] 226900009483 similar to Glutamine synthetase; EC_number 6.3.1.2 226900009484 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 226900009485 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900009486 DNA binding residues [nucleotide binding] 226900009487 putative dimer interface [polypeptide binding]; other site 226900009488 Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838 226900009489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900009490 catalytic residue [active] 226900009491 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 226900009492 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 226900009493 HflX GTPase family; Region: HflX; cd01878 226900009494 G1 box; other site 226900009495 GTP/Mg2+ binding site [chemical binding]; other site 226900009496 Switch I region; other site 226900009497 G2 box; other site 226900009498 G3 box; other site 226900009499 Switch II region; other site 226900009500 G4 box; other site 226900009501 G5 box; other site 226900009502 Predicted membrane protein [Function unknown]; Region: COG2860 226900009503 UPF0126 domain; Region: UPF0126; pfam03458 226900009504 UPF0126 domain; Region: UPF0126; pfam03458 226900009505 similar to Stage V sporulation protein K 226900009506 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 226900009507 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226900009508 active site 226900009509 catalytic residues [active] 226900009510 DNA binding site [nucleotide binding] 226900009511 Int/Topo IB signature motif; other site 226900009512 ARC105 or Med15 subunit of Mediator complex non-fungal; Region: Med15; pfam09606 226900009513 bacterial Hfq-like; Region: Hfq; cd01716 226900009514 hexamer interface [polypeptide binding]; other site 226900009515 Sm1 motif; other site 226900009516 RNA binding site [nucleotide binding]; other site 226900009517 Sm2 motif; other site 226900009518 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 226900009519 similar to enterotoxin / cell-wall binding protein 226900009520 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 226900009521 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 226900009522 active site 226900009523 phosphorylation site [posttranslational modification] 226900009524 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 226900009525 active site 226900009526 P-loop; other site 226900009527 phosphorylation site [posttranslational modification] 226900009528 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 226900009529 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 226900009530 putative substrate binding site [chemical binding]; other site 226900009531 putative ATP binding site [chemical binding]; other site 226900009532 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 226900009533 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 226900009534 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 226900009535 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 226900009536 dimer interface [polypeptide binding]; other site 226900009537 active site 226900009538 metal binding site [ion binding]; metal-binding site 226900009539 Predicted membrane protein [Function unknown]; Region: COG2322 226900009540 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 226900009541 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 226900009542 Glyco_18 domain; Region: Glyco_18; smart00636 226900009543 putative active site [active] 226900009544 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226900009545 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900009546 putative active site [active] 226900009547 putative metal binding site [ion binding]; other site 226900009548 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 226900009549 histone-like DNA-binding protein HU; Region: HU; cd13831 226900009550 dimer interface [polypeptide binding]; other site 226900009551 DNA binding site [nucleotide binding] 226900009552 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 226900009553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900009554 Coenzyme A binding pocket [chemical binding]; other site 226900009555 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226900009556 metal-binding site [ion binding] 226900009557 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 226900009558 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226900009559 metal-binding site [ion binding] 226900009560 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900009561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900009562 motif II; other site 226900009563 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 226900009564 metal-binding site [ion binding] 226900009565 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 226900009566 putative homodimer interface [polypeptide binding]; other site 226900009567 putative homotetramer interface [polypeptide binding]; other site 226900009568 allosteric switch controlling residues; other site 226900009569 putative metal binding site [ion binding]; other site 226900009570 putative homodimer-homodimer interface [polypeptide binding]; other site 226900009571 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 226900009572 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900009573 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900009574 Walker A/P-loop; other site 226900009575 ATP binding site [chemical binding]; other site 226900009576 Q-loop/lid; other site 226900009577 ABC transporter signature motif; other site 226900009578 Walker B; other site 226900009579 D-loop; other site 226900009580 H-loop/switch region; other site 226900009581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900009582 ABC-ATPase subunit interface; other site 226900009583 dimer interface [polypeptide binding]; other site 226900009584 putative PBP binding regions; other site 226900009585 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900009586 ABC-ATPase subunit interface; other site 226900009587 dimer interface [polypeptide binding]; other site 226900009588 putative PBP binding regions; other site 226900009589 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900009590 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 226900009591 putative ligand binding residues [chemical binding]; other site 226900009592 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 226900009593 active site 226900009594 putative catalytic site [active] 226900009595 DNA binding site [nucleotide binding] 226900009596 putative phosphate binding site [ion binding]; other site 226900009597 metal binding site A [ion binding]; metal-binding site 226900009598 AP binding site [nucleotide binding]; other site 226900009599 metal binding site B [ion binding]; metal-binding site 226900009600 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 226900009601 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 226900009602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900009603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900009604 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 226900009605 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 226900009606 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 226900009607 DNA binding site [nucleotide binding] 226900009608 active site 226900009609 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 226900009610 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 226900009611 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 226900009612 minor groove reading motif; other site 226900009613 helix-hairpin-helix signature motif; other site 226900009614 substrate binding pocket [chemical binding]; other site 226900009615 active site 226900009616 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 226900009617 peptidase T-like protein; Region: PepT-like; TIGR01883 226900009618 metal binding site [ion binding]; metal-binding site 226900009619 dimer interface [polypeptide binding]; other site 226900009620 hypothetical protein; Provisional; Region: PRK06764 226900009621 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900009622 catalytic core [active] 226900009623 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 226900009624 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900009625 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 226900009626 PAS domain S-box; Region: sensory_box; TIGR00229 226900009627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900009628 putative active site [active] 226900009629 heme pocket [chemical binding]; other site 226900009630 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900009631 metal binding site [ion binding]; metal-binding site 226900009632 active site 226900009633 I-site; other site 226900009634 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900009635 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 226900009636 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 226900009637 active site 226900009638 homodimer interface [polypeptide binding]; other site 226900009639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900009640 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 226900009641 NAD(P) binding site [chemical binding]; other site 226900009642 active site 226900009643 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 226900009644 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 226900009645 NAD(P) binding site [chemical binding]; other site 226900009646 homodimer interface [polypeptide binding]; other site 226900009647 substrate binding site [chemical binding]; other site 226900009648 active site 226900009649 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 226900009650 similar to hypothetical protein 226900009651 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 226900009652 LrgB-like family; Region: LrgB; cl00596 226900009653 holin-like protein; Validated; Region: PRK01658 226900009654 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 226900009655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900009656 DNA-binding site [nucleotide binding]; DNA binding site 226900009657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900009658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900009659 homodimer interface [polypeptide binding]; other site 226900009660 catalytic residue [active] 226900009661 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226900009662 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 226900009663 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 226900009664 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 226900009665 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 226900009666 active site 226900009667 catalytic site [active] 226900009668 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 226900009669 putative active site [active] 226900009670 putative catalytic triad [active] 226900009671 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 226900009672 similar to cell wall hydrolase cwlJ 226900009673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900009674 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226900009675 Sulfatase; Region: Sulfatase; pfam00884 226900009676 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226900009677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900009678 binding surface 226900009679 TPR motif; other site 226900009680 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 226900009681 G1 box; other site 226900009682 GTP/Mg2+ binding site [chemical binding]; other site 226900009683 Switch I region; other site 226900009684 G3 box; other site 226900009685 Switch II region; other site 226900009686 G4 box; other site 226900009687 G5 box; other site 226900009688 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 226900009689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900009690 ATP binding site [chemical binding]; other site 226900009691 Mg2+ binding site [ion binding]; other site 226900009692 G-X-G motif; other site 226900009693 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 226900009694 ATP binding site [chemical binding]; other site 226900009695 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 226900009696 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 226900009697 MutS domain I; Region: MutS_I; pfam01624 226900009698 MutS domain II; Region: MutS_II; pfam05188 226900009699 MutS domain III; Region: MutS_III; pfam05192 226900009700 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 226900009701 Walker A/P-loop; other site 226900009702 ATP binding site [chemical binding]; other site 226900009703 Q-loop/lid; other site 226900009704 ABC transporter signature motif; other site 226900009705 Walker B; other site 226900009706 D-loop; other site 226900009707 H-loop/switch region; other site 226900009708 Outer spore coat protein E (CotE); Region: CotE; pfam10628 226900009709 Predicted membrane protein [Function unknown]; Region: COG4550 226900009710 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 226900009711 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 226900009712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900009713 FeS/SAM binding site; other site 226900009714 TRAM domain; Region: TRAM; pfam01938 226900009715 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 226900009716 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 226900009717 TPP-binding site [chemical binding]; other site 226900009718 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 226900009719 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 226900009720 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 226900009721 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 226900009722 dimer interface [polypeptide binding]; other site 226900009723 PYR/PP interface [polypeptide binding]; other site 226900009724 TPP binding site [chemical binding]; other site 226900009725 substrate binding site [chemical binding]; other site 226900009726 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 226900009727 active site 226900009728 dimer interface [polypeptide binding]; other site 226900009729 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 226900009730 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 226900009731 putative active site [active] 226900009732 metal binding site [ion binding]; metal-binding site 226900009733 homodimer binding site [polypeptide binding]; other site 226900009734 phosphodiesterase; Provisional; Region: PRK12704 226900009735 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 226900009736 KH domain; Region: KH_1; pfam00013 226900009737 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900009738 Zn2+ binding site [ion binding]; other site 226900009739 Mg2+ binding site [ion binding]; other site 226900009740 recombinase A; Provisional; Region: recA; PRK09354 226900009741 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 226900009742 hexamer interface [polypeptide binding]; other site 226900009743 Walker A motif; other site 226900009744 ATP binding site [chemical binding]; other site 226900009745 Walker B motif; other site 226900009746 competence damage-inducible protein A; Provisional; Region: PRK00549 226900009747 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 226900009748 putative MPT binding site; other site 226900009749 Competence-damaged protein; Region: CinA; pfam02464 226900009750 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 226900009751 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 226900009752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900009753 non-specific DNA binding site [nucleotide binding]; other site 226900009754 salt bridge; other site 226900009755 sequence-specific DNA binding site [nucleotide binding]; other site 226900009756 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 226900009757 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 226900009758 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 226900009759 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 226900009760 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 226900009761 classical (c) SDRs; Region: SDR_c; cd05233 226900009762 NAD(P) binding site [chemical binding]; other site 226900009763 active site 226900009764 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226900009765 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 226900009766 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226900009767 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226900009768 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226900009769 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 226900009770 TM-ABC transporter signature motif; other site 226900009771 similar to nucleoside transport system permease 226900009772 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 226900009773 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 226900009774 Walker A/P-loop; other site 226900009775 ATP binding site [chemical binding]; other site 226900009776 Q-loop/lid; other site 226900009777 ABC transporter signature motif; other site 226900009778 Walker B; other site 226900009779 D-loop; other site 226900009780 H-loop/switch region; other site 226900009781 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 226900009782 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 226900009783 ligand binding site [chemical binding]; other site 226900009784 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226900009785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900009786 DNA-binding site [nucleotide binding]; DNA binding site 226900009787 UTRA domain; Region: UTRA; pfam07702 226900009788 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 226900009789 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226900009790 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 226900009791 YlzJ-like protein; Region: YlzJ; pfam14035 226900009792 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 226900009793 active site 226900009794 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 226900009795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900009796 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 226900009797 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 226900009798 dimer interface [polypeptide binding]; other site 226900009799 active site 226900009800 catalytic residue [active] 226900009801 aspartate kinase I; Reviewed; Region: PRK08210 226900009802 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 226900009803 nucleotide binding site [chemical binding]; other site 226900009804 substrate binding site [chemical binding]; other site 226900009805 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 226900009806 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 226900009807 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 226900009808 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 226900009809 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 226900009810 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 226900009811 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 226900009812 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 226900009813 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 226900009814 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 226900009815 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 226900009816 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 226900009817 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 226900009818 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 226900009819 NodB motif; other site 226900009820 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 226900009821 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 226900009822 RNase E interface [polypeptide binding]; other site 226900009823 trimer interface [polypeptide binding]; other site 226900009824 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 226900009825 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 226900009826 RNase E interface [polypeptide binding]; other site 226900009827 trimer interface [polypeptide binding]; other site 226900009828 active site 226900009829 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 226900009830 putative nucleic acid binding region [nucleotide binding]; other site 226900009831 G-X-X-G motif; other site 226900009832 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 226900009833 RNA binding site [nucleotide binding]; other site 226900009834 domain interface; other site 226900009835 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 226900009836 16S/18S rRNA binding site [nucleotide binding]; other site 226900009837 S13e-L30e interaction site [polypeptide binding]; other site 226900009838 25S rRNA binding site [nucleotide binding]; other site 226900009839 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 226900009840 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 226900009841 active site 226900009842 Riboflavin kinase; Region: Flavokinase; smart00904 226900009843 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 226900009844 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 226900009845 RNA binding site [nucleotide binding]; other site 226900009846 active site 226900009847 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 226900009848 Protein of unknown function (DUF503); Region: DUF503; pfam04456 226900009849 translation initiation factor IF-2; Validated; Region: infB; PRK05306 226900009850 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 226900009851 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 226900009852 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 226900009853 G1 box; other site 226900009854 putative GEF interaction site [polypeptide binding]; other site 226900009855 GTP/Mg2+ binding site [chemical binding]; other site 226900009856 Switch I region; other site 226900009857 G2 box; other site 226900009858 G3 box; other site 226900009859 Switch II region; other site 226900009860 G4 box; other site 226900009861 G5 box; other site 226900009862 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 226900009863 Translation-initiation factor 2; Region: IF-2; pfam11987 226900009864 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 226900009865 hypothetical protein; Provisional; Region: PRK07714 226900009866 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 226900009867 putative RNA binding cleft [nucleotide binding]; other site 226900009868 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 226900009869 NusA N-terminal domain; Region: NusA_N; pfam08529 226900009870 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 226900009871 RNA binding site [nucleotide binding]; other site 226900009872 homodimer interface [polypeptide binding]; other site 226900009873 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 226900009874 G-X-X-G motif; other site 226900009875 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 226900009876 G-X-X-G motif; other site 226900009877 hypothetical protein; Provisional; Region: PRK14641 226900009878 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 226900009879 putative oligomer interface [polypeptide binding]; other site 226900009880 putative RNA binding site [nucleotide binding]; other site 226900009881 DNA polymerase III PolC; Validated; Region: polC; PRK00448 226900009882 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 226900009883 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 226900009884 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 226900009885 generic binding surface II; other site 226900009886 generic binding surface I; other site 226900009887 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 226900009888 active site 226900009889 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 226900009890 active site 226900009891 catalytic site [active] 226900009892 substrate binding site [chemical binding]; other site 226900009893 putative PHP Thumb interface [polypeptide binding]; other site 226900009894 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 226900009895 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 226900009896 prolyl-tRNA synthetase; Provisional; Region: PRK09194 226900009897 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 226900009898 dimer interface [polypeptide binding]; other site 226900009899 motif 1; other site 226900009900 active site 226900009901 motif 2; other site 226900009902 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 226900009903 putative deacylase active site [active] 226900009904 motif 3; other site 226900009905 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 226900009906 anticodon binding site; other site 226900009907 similar to membrane metalloprotease 226900009908 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 226900009909 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 226900009910 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 226900009911 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 226900009912 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 226900009913 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 226900009914 active site 226900009915 dimer interface [polypeptide binding]; other site 226900009916 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 226900009917 hinge region; other site 226900009918 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 226900009919 putative nucleotide binding site [chemical binding]; other site 226900009920 uridine monophosphate binding site [chemical binding]; other site 226900009921 homohexameric interface [polypeptide binding]; other site 226900009922 elongation factor Ts; Provisional; Region: tsf; PRK09377 226900009923 UBA/TS-N domain; Region: UBA; pfam00627 226900009924 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 226900009925 rRNA interaction site [nucleotide binding]; other site 226900009926 S8 interaction site; other site 226900009927 putative laminin-1 binding site; other site 226900009928 transcriptional repressor CodY; Validated; Region: PRK04158 226900009929 CodY GAF-like domain; Region: CodY; pfam06018 226900009930 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 226900009931 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 226900009932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900009933 Walker A motif; other site 226900009934 ATP binding site [chemical binding]; other site 226900009935 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 226900009936 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 226900009937 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 226900009938 active site 226900009939 HslU subunit interaction site [polypeptide binding]; other site 226900009940 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 226900009941 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 226900009942 active site 226900009943 Int/Topo IB signature motif; other site 226900009944 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 226900009945 Glucose inhibited division protein A; Region: GIDA; pfam01134 226900009946 DNA topoisomerase I; Validated; Region: PRK05582 226900009947 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 226900009948 active site 226900009949 metal binding site [ion binding]; metal-binding site 226900009950 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 226900009951 domain I; other site 226900009952 DNA binding groove [nucleotide binding] 226900009953 phosphate binding site [ion binding]; other site 226900009954 domain II; other site 226900009955 domain III; other site 226900009956 nucleotide binding site [chemical binding]; other site 226900009957 catalytic site [active] 226900009958 domain IV; other site 226900009959 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 226900009960 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 226900009961 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 226900009962 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 226900009963 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 226900009964 CoA binding domain; Region: CoA_binding; pfam02629 226900009965 CoA-ligase; Region: Ligase_CoA; pfam00549 226900009966 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 226900009967 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 226900009968 CoA-ligase; Region: Ligase_CoA; pfam00549 226900009969 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 226900009970 RNA/DNA hybrid binding site [nucleotide binding]; other site 226900009971 active site 226900009972 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 226900009973 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 226900009974 GTP/Mg2+ binding site [chemical binding]; other site 226900009975 G4 box; other site 226900009976 G5 box; other site 226900009977 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 226900009978 G1 box; other site 226900009979 G1 box; other site 226900009980 GTP/Mg2+ binding site [chemical binding]; other site 226900009981 Switch I region; other site 226900009982 G2 box; other site 226900009983 G2 box; other site 226900009984 G3 box; other site 226900009985 G3 box; other site 226900009986 Switch II region; other site 226900009987 Switch II region; other site 226900009988 G4 box; other site 226900009989 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 226900009990 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 226900009991 Catalytic site [active] 226900009992 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 226900009993 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 226900009994 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 226900009995 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 226900009996 RimM N-terminal domain; Region: RimM; pfam01782 226900009997 PRC-barrel domain; Region: PRC; pfam05239 226900009998 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 226900009999 G-X-X-G motif; other site 226900010000 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 226900010001 signal recognition particle protein; Provisional; Region: PRK10867 226900010002 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 226900010003 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 226900010004 P loop; other site 226900010005 GTP binding site [chemical binding]; other site 226900010006 Signal peptide binding domain; Region: SRP_SPB; pfam02978 226900010007 putative DNA-binding protein; Validated; Region: PRK00118 226900010008 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 226900010009 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 226900010010 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 226900010011 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 226900010012 P loop; other site 226900010013 GTP binding site [chemical binding]; other site 226900010014 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 226900010015 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 226900010016 Walker A/P-loop; other site 226900010017 ATP binding site [chemical binding]; other site 226900010018 Q-loop/lid; other site 226900010019 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 226900010020 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 226900010021 ABC transporter signature motif; other site 226900010022 Walker B; other site 226900010023 D-loop; other site 226900010024 H-loop/switch region; other site 226900010025 ribonuclease III; Reviewed; Region: rnc; PRK00102 226900010026 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 226900010027 dimerization interface [polypeptide binding]; other site 226900010028 active site 226900010029 metal binding site [ion binding]; metal-binding site 226900010030 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 226900010031 dsRNA binding site [nucleotide binding]; other site 226900010032 acyl carrier protein; Provisional; Region: acpP; PRK00982 226900010033 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 226900010034 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 226900010035 NAD(P) binding site [chemical binding]; other site 226900010036 homotetramer interface [polypeptide binding]; other site 226900010037 homodimer interface [polypeptide binding]; other site 226900010038 active site 226900010039 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 226900010040 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 226900010041 putative phosphate acyltransferase; Provisional; Region: PRK05331 226900010042 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 226900010043 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 226900010044 active site 2 [active] 226900010045 active site 1 [active] 226900010046 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 226900010047 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 226900010048 generic binding surface II; other site 226900010049 ssDNA binding site; other site 226900010050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900010051 ATP binding site [chemical binding]; other site 226900010052 putative Mg++ binding site [ion binding]; other site 226900010053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900010054 nucleotide binding region [chemical binding]; other site 226900010055 ATP-binding site [chemical binding]; other site 226900010056 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 226900010057 DAK2 domain; Region: Dak2; pfam02734 226900010058 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 226900010059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 226900010060 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 226900010061 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 226900010062 Thiamine pyrophosphokinase; Region: TPK; cd07995 226900010063 active site 226900010064 dimerization interface [polypeptide binding]; other site 226900010065 thiamine binding site [chemical binding]; other site 226900010066 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 226900010067 substrate binding site [chemical binding]; other site 226900010068 hexamer interface [polypeptide binding]; other site 226900010069 metal binding site [ion binding]; metal-binding site 226900010070 GTPase RsgA; Reviewed; Region: PRK00098 226900010071 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 226900010072 RNA binding site [nucleotide binding]; other site 226900010073 homodimer interface [polypeptide binding]; other site 226900010074 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 226900010075 GTPase/Zn-binding domain interface [polypeptide binding]; other site 226900010076 GTP/Mg2+ binding site [chemical binding]; other site 226900010077 G4 box; other site 226900010078 G5 box; other site 226900010079 G1 box; other site 226900010080 Switch I region; other site 226900010081 G2 box; other site 226900010082 G3 box; other site 226900010083 Switch II region; other site 226900010084 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 226900010085 Catalytic domain of Protein Kinases; Region: PKc; cd00180 226900010086 active site 226900010087 ATP binding site [chemical binding]; other site 226900010088 substrate binding site [chemical binding]; other site 226900010089 activation loop (A-loop); other site 226900010090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 226900010091 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226900010092 PASTA domain; Region: PASTA; pfam03793 226900010093 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 226900010094 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 226900010095 active site 226900010096 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 226900010097 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 226900010098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900010099 FeS/SAM binding site; other site 226900010100 16S rRNA methyltransferase B; Provisional; Region: PRK14902 226900010101 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 226900010102 putative RNA binding site [nucleotide binding]; other site 226900010103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900010104 S-adenosylmethionine binding site [chemical binding]; other site 226900010105 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 226900010106 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 226900010107 putative active site [active] 226900010108 substrate binding site [chemical binding]; other site 226900010109 putative cosubstrate binding site; other site 226900010110 catalytic site [active] 226900010111 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 226900010112 substrate binding site [chemical binding]; other site 226900010113 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 226900010114 active site 226900010115 catalytic residues [active] 226900010116 metal binding site [ion binding]; metal-binding site 226900010117 primosome assembly protein PriA; Validated; Region: PRK05580 226900010118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900010119 ATP binding site [chemical binding]; other site 226900010120 putative Mg++ binding site [ion binding]; other site 226900010121 helicase superfamily c-terminal domain; Region: HELICc; smart00490 226900010122 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 226900010123 Flavoprotein; Region: Flavoprotein; cl19190 226900010124 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 226900010125 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 226900010126 Guanylate kinase; Region: Guanylate_kin; pfam00625 226900010127 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 226900010128 catalytic site [active] 226900010129 G-X2-G-X-G-K; other site 226900010130 hypothetical protein; Provisional; Region: PRK04323 226900010131 hypothetical protein; Provisional; Region: PRK11820 226900010132 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 226900010133 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 226900010134 similar to calcium-transporting ATPase; EC_number 3.6.3.8 226900010135 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 226900010136 Domain of unknown function (DUF814); Region: DUF814; pfam05670 226900010137 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 226900010138 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226900010139 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226900010140 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 226900010141 active site 226900010142 DinB superfamily; Region: DinB_2; pfam12867 226900010143 YoqO-like protein; Region: YoqO; pfam14037 226900010144 YoqO-like protein; Region: YoqO; pfam14037 226900010145 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 226900010146 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 226900010147 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 226900010148 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900010149 active site 226900010150 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 226900010151 active site 226900010152 dimer interface [polypeptide binding]; other site 226900010153 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 226900010154 heterodimer interface [polypeptide binding]; other site 226900010155 active site 226900010156 FMN binding site [chemical binding]; other site 226900010157 homodimer interface [polypeptide binding]; other site 226900010158 substrate binding site [chemical binding]; other site 226900010159 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 226900010160 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 226900010161 FAD binding pocket [chemical binding]; other site 226900010162 FAD binding motif [chemical binding]; other site 226900010163 phosphate binding motif [ion binding]; other site 226900010164 beta-alpha-beta structure motif; other site 226900010165 NAD binding pocket [chemical binding]; other site 226900010166 Iron coordination center [ion binding]; other site 226900010167 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 226900010168 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900010169 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 226900010170 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 226900010171 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900010172 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226900010173 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 226900010174 IMP binding site; other site 226900010175 dimer interface [polypeptide binding]; other site 226900010176 interdomain contacts; other site 226900010177 partial ornithine binding site; other site 226900010178 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 226900010179 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 226900010180 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 226900010181 catalytic site [active] 226900010182 subunit interface [polypeptide binding]; other site 226900010183 dihydroorotase; Validated; Region: pyrC; PRK09357 226900010184 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 226900010185 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 226900010186 active site 226900010187 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 226900010188 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226900010189 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 226900010190 Sulfate transporter family; Region: Sulfate_transp; cl19250 226900010191 uracil-xanthine permease; Region: ncs2; TIGR00801 226900010192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900010193 active site 226900010194 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 226900010195 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900010196 RNA binding surface [nucleotide binding]; other site 226900010197 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 226900010198 active site 226900010199 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 226900010200 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 226900010201 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 226900010202 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 226900010203 active site 226900010204 HIGH motif; other site 226900010205 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 226900010206 KMSKS motif; other site 226900010207 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 226900010208 tRNA binding surface [nucleotide binding]; other site 226900010209 anticodon binding site; other site 226900010210 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 226900010211 DivIVA protein; Region: DivIVA; pfam05103 226900010212 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 226900010213 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 226900010214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900010215 RNA binding surface [nucleotide binding]; other site 226900010216 YGGT family; Region: YGGT; pfam02325 226900010217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 226900010218 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 226900010219 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 226900010220 catalytic residue [active] 226900010221 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 226900010222 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 226900010223 sporulation sigma factor SigG; Reviewed; Region: PRK08215 226900010224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900010225 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226900010226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900010227 DNA binding residues [nucleotide binding] 226900010228 sporulation sigma factor SigE; Reviewed; Region: PRK08301 226900010229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900010230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900010231 DNA binding residues [nucleotide binding] 226900010232 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 226900010233 cell division protein FtsZ; Validated; Region: PRK09330 226900010234 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 226900010235 nucleotide binding site [chemical binding]; other site 226900010236 SulA interaction site; other site 226900010237 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 226900010238 Cell division protein FtsA; Region: FtsA; smart00842 226900010239 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226900010240 nucleotide binding site [chemical binding]; other site 226900010241 Cell division protein FtsA; Region: FtsA; pfam14450 226900010242 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 226900010243 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 226900010244 Cell division protein FtsQ; Region: FtsQ; pfam03799 226900010245 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 226900010246 FAD binding domain; Region: FAD_binding_4; pfam01565 226900010247 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 226900010248 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 226900010249 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 226900010250 active site 226900010251 homodimer interface [polypeptide binding]; other site 226900010252 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 226900010253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900010254 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 226900010255 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226900010256 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900010257 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 226900010258 Mg++ binding site [ion binding]; other site 226900010259 putative catalytic motif [active] 226900010260 putative substrate binding site [chemical binding]; other site 226900010261 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 226900010262 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226900010263 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226900010264 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900010265 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 226900010266 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900010267 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900010268 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 226900010269 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900010270 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900010271 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900010272 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 226900010273 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 226900010274 Cell division protein FtsL; Region: FtsL; cl11433 226900010275 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 226900010276 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 226900010277 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 226900010278 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 226900010279 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 226900010280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900010281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900010282 Coenzyme A binding pocket [chemical binding]; other site 226900010283 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 226900010284 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 226900010285 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 226900010286 similar to hypothetical Cytosolic Protein 226900010287 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 226900010288 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 226900010289 protein binding site [polypeptide binding]; other site 226900010290 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 226900010291 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 226900010292 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 226900010293 active site 226900010294 nucleophile elbow; other site 226900010295 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 226900010296 Nucleoside recognition; Region: Gate; pfam07670 226900010297 Nucleoside recognition; Region: Gate; pfam07670 226900010298 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 226900010299 active site 226900010300 (T/H)XGH motif; other site 226900010301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900010302 S-adenosylmethionine binding site [chemical binding]; other site 226900010303 hypothetical protein; Provisional; Region: PRK02886 226900010304 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 226900010305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900010306 catalytic core [active] 226900010307 YlbE-like protein; Region: YlbE; pfam14003 226900010308 Putative coat protein; Region: YlbD_coat; pfam14071 226900010309 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 226900010310 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 226900010311 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 226900010312 YugN-like family; Region: YugN; pfam08868 226900010313 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 226900010314 multimer interface [polypeptide binding]; other site 226900010315 active site 226900010316 catalytic triad [active] 226900010317 dimer interface [polypeptide binding]; other site 226900010318 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 226900010319 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 226900010320 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 226900010321 Subunit I/III interface [polypeptide binding]; other site 226900010322 Subunit III/IV interface [polypeptide binding]; other site 226900010323 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 226900010324 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 226900010325 D-pathway; other site 226900010326 Putative ubiquinol binding site [chemical binding]; other site 226900010327 Low-spin heme (heme b) binding site [chemical binding]; other site 226900010328 Putative water exit pathway; other site 226900010329 Binuclear center (heme o3/CuB) [ion binding]; other site 226900010330 K-pathway; other site 226900010331 Putative proton exit pathway; other site 226900010332 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 226900010333 The cupredoxin domain of Caa3 type Cytochrome c oxidase subunit II; Region: CuRO_CcO_Caa3_II; cd04213 226900010334 oligomer interface [polypeptide binding]; other site 226900010335 CuA binuclear center [ion binding]; other site 226900010336 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 226900010337 Cytochrome c; Region: Cytochrom_C; pfam00034 226900010338 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 226900010339 putative active site [active] 226900010340 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 226900010341 pyruvate carboxylase; Reviewed; Region: PRK12999 226900010342 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900010343 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 226900010344 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 226900010345 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 226900010346 active site 226900010347 catalytic residues [active] 226900010348 metal binding site [ion binding]; metal-binding site 226900010349 homodimer binding site [polypeptide binding]; other site 226900010350 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 226900010351 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226900010352 carboxyltransferase (CT) interaction site; other site 226900010353 biotinylation site [posttranslational modification]; other site 226900010354 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 226900010355 hypothetical protein; Provisional; Region: PRK13666 226900010356 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 226900010357 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 226900010358 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 226900010359 putative active site [active] 226900010360 PhoH-like protein; Region: PhoH; pfam02562 226900010361 hypothetical protein; Provisional; Region: PRK06733 226900010362 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 226900010363 YlaH-like protein; Region: YlaH; pfam14036 226900010364 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 226900010365 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 226900010366 G1 box; other site 226900010367 putative GEF interaction site [polypeptide binding]; other site 226900010368 GTP/Mg2+ binding site [chemical binding]; other site 226900010369 Switch I region; other site 226900010370 G2 box; other site 226900010371 G3 box; other site 226900010372 Switch II region; other site 226900010373 G4 box; other site 226900010374 G5 box; other site 226900010375 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 226900010376 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226900010377 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 226900010378 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 226900010379 active site 226900010380 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 226900010381 hypothetical protein; Provisional; Region: PRK04387 226900010382 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 226900010383 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 226900010384 homodimer interface [polypeptide binding]; other site 226900010385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010386 catalytic residue [active] 226900010387 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 226900010388 transglutaminase; Provisional; Region: tgl; PRK03187 226900010389 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 226900010390 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 226900010391 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 226900010392 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 226900010393 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 226900010394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900010395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900010396 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226900010397 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 226900010398 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226900010399 E3 interaction surface; other site 226900010400 lipoyl attachment site [posttranslational modification]; other site 226900010401 e3 binding domain; Region: E3_binding; pfam02817 226900010402 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 226900010403 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 226900010404 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 226900010405 alpha subunit interface [polypeptide binding]; other site 226900010406 TPP binding site [chemical binding]; other site 226900010407 heterodimer interface [polypeptide binding]; other site 226900010408 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900010409 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 226900010410 TPP-binding site [chemical binding]; other site 226900010411 heterodimer interface [polypeptide binding]; other site 226900010412 tetramer interface [polypeptide binding]; other site 226900010413 phosphorylation loop region [posttranslational modification] 226900010414 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 226900010415 active site 226900010416 catalytic residues [active] 226900010417 metal binding site [ion binding]; metal-binding site 226900010418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900010419 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900010420 active site 226900010421 motif I; other site 226900010422 motif II; other site 226900010423 hypothetical protein; Provisional; Region: PRK13667 226900010424 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 226900010425 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900010426 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 226900010427 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 226900010428 TrkA-N domain; Region: TrkA_N; pfam02254 226900010429 TrkA-C domain; Region: TrkA_C; pfam02080 226900010430 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 226900010431 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 226900010432 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 226900010433 metal binding site [ion binding]; metal-binding site 226900010434 putative dimer interface [polypeptide binding]; other site 226900010435 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 226900010436 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 226900010437 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 226900010438 trimer interface [polypeptide binding]; other site 226900010439 active site 226900010440 substrate binding site [chemical binding]; other site 226900010441 CoA binding site [chemical binding]; other site 226900010442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900010443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900010444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900010445 dimerization interface [polypeptide binding]; other site 226900010446 FOG: CBS domain [General function prediction only]; Region: COG0517 226900010447 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 226900010448 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 226900010449 Protein of unknown function (DUF458); Region: DUF458; pfam04308 226900010450 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 226900010451 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 226900010452 catalytic residues [active] 226900010453 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 226900010454 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900010455 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 226900010456 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 226900010457 short chain dehydrogenase; Provisional; Region: PRK07677 226900010458 NAD(P) binding site [chemical binding]; other site 226900010459 substrate binding site [chemical binding]; other site 226900010460 homotetramer interface [polypeptide binding]; other site 226900010461 active site 226900010462 homodimer interface [polypeptide binding]; other site 226900010463 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 226900010464 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 226900010465 putative active site [active] 226900010466 putative metal binding site [ion binding]; other site 226900010467 polyphosphate kinase; Provisional; Region: PRK05443 226900010468 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 226900010469 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 226900010470 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 226900010471 putative domain interface [polypeptide binding]; other site 226900010472 putative active site [active] 226900010473 catalytic site [active] 226900010474 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 226900010475 putative domain interface [polypeptide binding]; other site 226900010476 putative active site [active] 226900010477 catalytic site [active] 226900010478 exopolyphosphatase; Region: exo_poly_only; TIGR03706 226900010479 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 226900010480 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226900010481 nucleotide binding site [chemical binding]; other site 226900010482 YkyB-like protein; Region: YkyB; pfam14177 226900010483 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 226900010484 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 226900010485 metal binding site [ion binding]; metal-binding site 226900010486 Phage lysis protein, holin; Region: Phage_holin; cl04675 226900010487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900010488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900010489 putative substrate translocation pore; other site 226900010490 Predicted transcriptional regulators [Transcription]; Region: COG1695 226900010491 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 226900010492 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 226900010493 THF binding site; other site 226900010494 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 226900010495 substrate binding site [chemical binding]; other site 226900010496 THF binding site; other site 226900010497 zinc-binding site [ion binding]; other site 226900010498 Competence protein J (ComJ); Region: ComJ; pfam11033 226900010499 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 226900010500 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 226900010501 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 226900010502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900010503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900010504 dimer interface [polypeptide binding]; other site 226900010505 phosphorylation site [posttranslational modification] 226900010506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900010507 ATP binding site [chemical binding]; other site 226900010508 Mg2+ binding site [ion binding]; other site 226900010509 G-X-G motif; other site 226900010510 aminotransferase A; Validated; Region: PRK07683 226900010511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900010512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010513 homodimer interface [polypeptide binding]; other site 226900010514 catalytic residue [active] 226900010515 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900010516 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900010517 DNA binding site [nucleotide binding] 226900010518 domain linker motif; other site 226900010519 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 226900010520 putative dimerization interface [polypeptide binding]; other site 226900010521 putative ligand binding site [chemical binding]; other site 226900010522 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 226900010523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900010524 dimer interface [polypeptide binding]; other site 226900010525 conserved gate region; other site 226900010526 putative PBP binding loops; other site 226900010527 ABC-ATPase subunit interface; other site 226900010528 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 226900010529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900010530 dimer interface [polypeptide binding]; other site 226900010531 conserved gate region; other site 226900010532 putative PBP binding loops; other site 226900010533 ABC-ATPase subunit interface; other site 226900010534 similar to Cyclodextrin-binding protein 226900010535 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 226900010536 homodimer interface [polypeptide binding]; other site 226900010537 maltodextrin glucosidase; Provisional; Region: PRK10785 226900010538 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 226900010539 active site 226900010540 homodimer interface [polypeptide binding]; other site 226900010541 catalytic site [active] 226900010542 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 226900010543 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 226900010544 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 226900010545 Ca binding site [ion binding]; other site 226900010546 active site 226900010547 catalytic site [active] 226900010548 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 226900010549 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 226900010550 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 226900010551 Walker A/P-loop; other site 226900010552 ATP binding site [chemical binding]; other site 226900010553 Q-loop/lid; other site 226900010554 ABC transporter signature motif; other site 226900010555 Walker B; other site 226900010556 D-loop; other site 226900010557 H-loop/switch region; other site 226900010558 TOBE domain; Region: TOBE_2; pfam08402 226900010559 hypothetical protein; Provisional; Region: PRK06720 226900010560 NAD(P) binding site [chemical binding]; other site 226900010561 RDD family; Region: RDD; pfam06271 226900010562 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 226900010563 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 226900010564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900010565 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 226900010566 Walker A/P-loop; other site 226900010567 ATP binding site [chemical binding]; other site 226900010568 Q-loop/lid; other site 226900010569 ABC transporter signature motif; other site 226900010570 Walker B; other site 226900010571 D-loop; other site 226900010572 H-loop/switch region; other site 226900010573 putative acyltransferase; Provisional; Region: PRK05790 226900010574 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 226900010575 dimer interface [polypeptide binding]; other site 226900010576 active site 226900010577 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 226900010578 nudix motif; other site 226900010579 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 226900010580 hypothetical protein; Validated; Region: PRK07668 226900010581 hypothetical protein; Validated; Region: PRK07668 226900010582 Predicted transcriptional regulators [Transcription]; Region: COG1695 226900010583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 226900010584 short chain dehydrogenase; Provisional; Region: PRK07577 226900010585 NAD(P) binding site [chemical binding]; other site 226900010586 active site 226900010587 YvrJ protein family; Region: YvrJ; pfam12841 226900010588 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 226900010589 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 226900010590 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 226900010591 putative active site [active] 226900010592 catalytic triad [active] 226900010593 putative dimer interface [polypeptide binding]; other site 226900010594 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 226900010595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900010596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010597 homodimer interface [polypeptide binding]; other site 226900010598 catalytic residue [active] 226900010599 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 226900010600 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 226900010601 dimer interface [polypeptide binding]; other site 226900010602 active site 226900010603 catalytic residue [active] 226900010604 metal binding site [ion binding]; metal-binding site 226900010605 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 226900010606 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 226900010607 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 226900010608 intersubunit interface [polypeptide binding]; other site 226900010609 active site 226900010610 Zn2+ binding site [ion binding]; other site 226900010611 Cupin domain; Region: Cupin_2; cl17218 226900010612 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 226900010613 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 226900010614 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 226900010615 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 226900010616 Beta-lactamase; Region: Beta-lactamase; pfam00144 226900010617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900010618 metal binding site [ion binding]; metal-binding site 226900010619 active site 226900010620 I-site; other site 226900010621 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 226900010622 dimer interface [polypeptide binding]; other site 226900010623 FMN binding site [chemical binding]; other site 226900010624 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 226900010625 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 226900010626 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 226900010627 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 226900010628 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 226900010629 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 226900010630 dimerization domain swap beta strand [polypeptide binding]; other site 226900010631 regulatory protein interface [polypeptide binding]; other site 226900010632 active site 226900010633 regulatory phosphorylation site [posttranslational modification]; other site 226900010634 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 226900010635 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 226900010636 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 226900010637 active site turn [active] 226900010638 phosphorylation site [posttranslational modification] 226900010639 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 226900010640 HPr interaction site; other site 226900010641 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226900010642 active site 226900010643 phosphorylation site [posttranslational modification] 226900010644 transcriptional antiterminator BglG; Provisional; Region: PRK09772 226900010645 CAT RNA binding domain; Region: CAT_RBD; smart01061 226900010646 PRD domain; Region: PRD; pfam00874 226900010647 PRD domain; Region: PRD; pfam00874 226900010648 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900010649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900010650 active site 226900010651 motif I; other site 226900010652 motif II; other site 226900010653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900010654 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900010655 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226900010656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900010657 DNA-binding site [nucleotide binding]; DNA binding site 226900010658 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 226900010659 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 226900010660 active site 226900010661 trimer interface [polypeptide binding]; other site 226900010662 allosteric site; other site 226900010663 active site lid [active] 226900010664 hexamer (dimer of trimers) interface [polypeptide binding]; other site 226900010665 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 226900010666 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 226900010667 active site 226900010668 dimer interface [polypeptide binding]; other site 226900010669 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 226900010670 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900010671 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 226900010672 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 226900010673 Domain of unknown function (DUF309); Region: DUF309; pfam03745 226900010674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900010675 Coenzyme A binding pocket [chemical binding]; other site 226900010676 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 226900010677 active site 226900010678 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 226900010679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900010680 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900010681 active site 226900010682 motif I; other site 226900010683 motif II; other site 226900010684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900010685 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900010686 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900010687 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 226900010688 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 226900010689 stage V sporulation protein AD; Validated; Region: PRK08304 226900010690 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 226900010691 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 226900010692 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 226900010693 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 226900010694 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 226900010695 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 226900010696 Na2 binding site [ion binding]; other site 226900010697 putative substrate binding site 1 [chemical binding]; other site 226900010698 Na binding site 1 [ion binding]; other site 226900010699 putative substrate binding site 2 [chemical binding]; other site 226900010700 sporulation sigma factor SigF; Validated; Region: PRK05572 226900010701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900010702 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226900010703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900010704 DNA binding residues [nucleotide binding] 226900010705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900010706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900010707 ATP binding site [chemical binding]; other site 226900010708 Mg2+ binding site [ion binding]; other site 226900010709 G-X-G motif; other site 226900010710 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 226900010711 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900010712 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 226900010713 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 226900010714 Predicted transcriptional regulators [Transcription]; Region: COG1725 226900010715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900010716 DNA-binding site [nucleotide binding]; DNA binding site 226900010717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900010718 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900010719 Walker A/P-loop; other site 226900010720 ATP binding site [chemical binding]; other site 226900010721 Q-loop/lid; other site 226900010722 ABC transporter signature motif; other site 226900010723 Walker B; other site 226900010724 D-loop; other site 226900010725 H-loop/switch region; other site 226900010726 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 226900010727 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900010728 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900010729 dimerization interface [polypeptide binding]; other site 226900010730 putative Zn2+ binding site [ion binding]; other site 226900010731 putative DNA binding site [nucleotide binding]; other site 226900010732 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 226900010733 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 226900010734 Sulfate transporter family; Region: Sulfate_transp; cl19250 226900010735 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 226900010736 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 226900010737 oligomer interface [polypeptide binding]; other site 226900010738 metal binding site [ion binding]; metal-binding site 226900010739 metal binding site [ion binding]; metal-binding site 226900010740 putative Cl binding site [ion binding]; other site 226900010741 aspartate ring; other site 226900010742 basic sphincter; other site 226900010743 hydrophobic gate; other site 226900010744 periplasmic entrance; other site 226900010745 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 226900010746 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 226900010747 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 226900010748 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 226900010749 purine nucleoside phosphorylase; Provisional; Region: PRK08202 226900010750 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 226900010751 phosphopentomutase; Provisional; Region: PRK05362 226900010752 YtkA-like; Region: YtkA; pfam13115 226900010753 YtkA-like; Region: YtkA; pfam13115 226900010754 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 226900010755 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 226900010756 active site 226900010757 Int/Topo IB signature motif; other site 226900010758 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 226900010759 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226900010760 metal binding site 2 [ion binding]; metal-binding site 226900010761 putative DNA binding helix; other site 226900010762 metal binding site 1 [ion binding]; metal-binding site 226900010763 dimer interface [polypeptide binding]; other site 226900010764 structural Zn2+ binding site [ion binding]; other site 226900010765 stage II sporulation protein M; Region: spo_II_M; TIGR02831 226900010766 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900010767 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 226900010768 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 226900010769 dimer interface [polypeptide binding]; other site 226900010770 ADP-ribose binding site [chemical binding]; other site 226900010771 active site 226900010772 nudix motif; other site 226900010773 metal binding site [ion binding]; metal-binding site 226900010774 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 226900010775 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900010776 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 226900010777 active site 226900010778 catalytic tetrad [active] 226900010779 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900010780 active site 226900010781 catalytic tetrad [active] 226900010782 GrpB protein; Region: GrpB; pfam04229 226900010783 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 226900010784 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226900010785 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 226900010786 putative active site [active] 226900010787 putative metal binding site [ion binding]; other site 226900010788 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226900010789 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 226900010790 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 226900010791 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900010792 Predicted permease [General function prediction only]; Region: COG2056 226900010793 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 226900010794 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 226900010795 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900010796 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900010797 DNA binding site [nucleotide binding] 226900010798 domain linker motif; other site 226900010799 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 226900010800 dimerization interface [polypeptide binding]; other site 226900010801 ligand binding site [chemical binding]; other site 226900010802 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900010803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900010804 Coenzyme A binding pocket [chemical binding]; other site 226900010805 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 226900010806 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900010807 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 226900010808 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 226900010809 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 226900010810 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 226900010811 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 226900010812 catalytic motif [active] 226900010813 Zn binding site [ion binding]; other site 226900010814 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 226900010815 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 226900010816 Lumazine binding domain; Region: Lum_binding; pfam00677 226900010817 Lumazine binding domain; Region: Lum_binding; pfam00677 226900010818 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 226900010819 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 226900010820 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 226900010821 dimerization interface [polypeptide binding]; other site 226900010822 active site 226900010823 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 226900010824 homopentamer interface [polypeptide binding]; other site 226900010825 active site 226900010826 biotin synthase; Validated; Region: PRK06256 226900010827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900010828 FeS/SAM binding site; other site 226900010829 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 226900010830 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 226900010831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900010832 S-adenosylmethionine binding site [chemical binding]; other site 226900010833 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900010834 Protein of unknown function (DUF452); Region: DUF452; cl01062 226900010835 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900010836 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 226900010837 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 226900010838 substrate-cofactor binding pocket; other site 226900010839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010840 catalytic residue [active] 226900010841 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 226900010842 AAA domain; Region: AAA_26; pfam13500 226900010843 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 226900010844 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900010845 inhibitor-cofactor binding pocket; inhibition site 226900010846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010847 catalytic residue [active] 226900010848 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 226900010849 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226900010850 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 226900010851 similar to 2',3'-cyclic-nucleotide 2'-phosphodiesterase; EC_number 3.1.4.16 226900010852 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 226900010853 active site 226900010854 catalytic triad [active] 226900010855 oxyanion hole [active] 226900010856 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900010857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900010858 dimerization interface [polypeptide binding]; other site 226900010859 putative DNA binding site [nucleotide binding]; other site 226900010860 putative Zn2+ binding site [ion binding]; other site 226900010861 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 226900010862 ornithine carbamoyltransferase; Provisional; Region: PRK00779 226900010863 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 226900010864 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 226900010865 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 226900010866 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900010867 inhibitor-cofactor binding pocket; inhibition site 226900010868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900010869 catalytic residue [active] 226900010870 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 226900010871 nucleotide binding site [chemical binding]; other site 226900010872 N-acetyl-L-glutamate binding site [chemical binding]; other site 226900010873 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 226900010874 heterotetramer interface [polypeptide binding]; other site 226900010875 active site pocket [active] 226900010876 cleavage site 226900010877 similar to N-acetyl-gamma-glutamyl-phosphate reductase; EC_number 1.2.1.38 226900010878 YqzH-like protein; Region: YqzH; pfam14164 226900010879 similar to Ketoacyl reductase hetN; EC_number 1.3.1.- 226900010880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900010881 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 226900010882 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 226900010883 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 226900010884 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 226900010885 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 226900010886 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 226900010887 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 226900010888 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 226900010889 putative L-serine binding site [chemical binding]; other site 226900010890 ribonuclease Z; Region: RNase_Z; TIGR02651 226900010891 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 226900010892 magnesium-transporting ATPase; Provisional; Region: PRK15122 226900010893 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 226900010894 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 226900010895 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 226900010896 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 226900010897 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 226900010898 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 226900010899 MgtC family; Region: MgtC; pfam02308 226900010900 DNA polymerase IV; Validated; Region: PRK01810 226900010901 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 226900010902 active site 226900010903 DNA binding site [nucleotide binding] 226900010904 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 226900010905 peptidase T-like protein; Region: PepT-like; TIGR01883 226900010906 metal binding site [ion binding]; metal-binding site 226900010907 putative dimer interface [polypeptide binding]; other site 226900010908 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900010909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900010910 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 226900010911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 226900010912 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 226900010913 Predicted membrane protein [Function unknown]; Region: COG4129 226900010914 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 226900010915 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 226900010916 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 226900010917 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 226900010918 Walker A/P-loop; other site 226900010919 ATP binding site [chemical binding]; other site 226900010920 Q-loop/lid; other site 226900010921 ABC transporter signature motif; other site 226900010922 Walker B; other site 226900010923 D-loop; other site 226900010924 H-loop/switch region; other site 226900010925 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226900010926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900010927 dimer interface [polypeptide binding]; other site 226900010928 conserved gate region; other site 226900010929 putative PBP binding loops; other site 226900010930 ABC-ATPase subunit interface; other site 226900010931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 226900010932 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 226900010933 substrate binding pocket [chemical binding]; other site 226900010934 membrane-bound complex binding site; other site 226900010935 hinge residues; other site 226900010936 Disulphide isomerase; Region: Disulph_isomer; pfam06491 226900010937 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 226900010938 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 226900010939 nudix motif; other site 226900010940 Predicted membrane protein [Function unknown]; Region: COG2323 226900010941 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 226900010942 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 226900010943 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 226900010944 E3 interaction surface; other site 226900010945 lipoyl attachment site [posttranslational modification]; other site 226900010946 e3 binding domain; Region: E3_binding; pfam02817 226900010947 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 226900010948 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 226900010949 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 226900010950 alpha subunit interface [polypeptide binding]; other site 226900010951 TPP binding site [chemical binding]; other site 226900010952 heterodimer interface [polypeptide binding]; other site 226900010953 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900010954 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 226900010955 tetramer interface [polypeptide binding]; other site 226900010956 TPP-binding site [chemical binding]; other site 226900010957 heterodimer interface [polypeptide binding]; other site 226900010958 phosphorylation loop region [posttranslational modification] 226900010959 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 226900010960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900010961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900010962 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 226900010963 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226900010964 nucleotide binding site [chemical binding]; other site 226900010965 Acetokinase family; Region: Acetate_kinase; cl17229 226900010966 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 226900010967 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 226900010968 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 226900010969 NAD binding site [chemical binding]; other site 226900010970 Phe binding site; other site 226900010971 phosphate butyryltransferase; Validated; Region: PRK07742 226900010972 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 226900010973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900010974 putative active site [active] 226900010975 heme pocket [chemical binding]; other site 226900010976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900010977 putative active site [active] 226900010978 heme pocket [chemical binding]; other site 226900010979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900010980 Walker A motif; other site 226900010981 ATP binding site [chemical binding]; other site 226900010982 Walker B motif; other site 226900010983 arginine finger; other site 226900010984 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 226900010985 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 226900010986 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226900010987 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 226900010988 active site 226900010989 catalytic site [active] 226900010990 metal binding site [ion binding]; metal-binding site 226900010991 dimer interface [polypeptide binding]; other site 226900010992 YycC-like protein; Region: YycC; pfam14174 226900010993 hypothetical protein; Provisional; Region: PRK06770 226900010994 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 226900010995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900010996 active site 226900010997 phosphorylation site [posttranslational modification] 226900010998 intermolecular recognition site; other site 226900010999 dimerization interface [polypeptide binding]; other site 226900011000 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 226900011001 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 226900011002 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 226900011003 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 226900011004 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 226900011005 similar to DNA repair protein recN 226900011006 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 226900011007 arginine repressor; Provisional; Region: PRK04280 226900011008 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 226900011009 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 226900011010 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900011011 RNA binding surface [nucleotide binding]; other site 226900011012 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 226900011013 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 226900011014 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 226900011015 TPP-binding site; other site 226900011016 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 226900011017 PYR/PP interface [polypeptide binding]; other site 226900011018 dimer interface [polypeptide binding]; other site 226900011019 TPP binding site [chemical binding]; other site 226900011020 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 226900011021 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 226900011022 substrate binding pocket [chemical binding]; other site 226900011023 chain length determination region; other site 226900011024 active site lid residues [active] 226900011025 substrate-Mg2+ binding site; other site 226900011026 catalytic residues [active] 226900011027 aspartate-rich region 1; other site 226900011028 aspartate-rich region 2; other site 226900011029 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 226900011030 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 226900011031 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 226900011032 generic binding surface II; other site 226900011033 generic binding surface I; other site 226900011034 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 226900011035 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 226900011036 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 226900011037 homodimer interface [polypeptide binding]; other site 226900011038 NADP binding site [chemical binding]; other site 226900011039 substrate binding site [chemical binding]; other site 226900011040 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 226900011041 putative RNA binding site [nucleotide binding]; other site 226900011042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 226900011043 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 226900011044 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 226900011045 ATP-grasp domain; Region: ATP-grasp_4; cl17255 226900011046 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 226900011047 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 226900011048 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 226900011049 carboxyltransferase (CT) interaction site; other site 226900011050 biotinylation site [posttranslational modification]; other site 226900011051 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 226900011052 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 226900011053 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 226900011054 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 226900011055 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 226900011056 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 226900011057 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 226900011058 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 226900011059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011060 Walker A motif; other site 226900011061 ATP binding site [chemical binding]; other site 226900011062 Walker B motif; other site 226900011063 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 226900011064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900011065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900011066 elongation factor P; Validated; Region: PRK00529 226900011067 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 226900011068 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 226900011069 RNA binding site [nucleotide binding]; other site 226900011070 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 226900011071 RNA binding site [nucleotide binding]; other site 226900011072 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226900011073 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226900011074 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 226900011075 active site 226900011076 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 226900011077 trimer interface [polypeptide binding]; other site 226900011078 active site 226900011079 dimer interface [polypeptide binding]; other site 226900011080 Conserved membrane protein YqhR; Region: YqhR; pfam11085 226900011081 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 226900011082 Carbon starvation protein CstA; Region: CstA; pfam02554 226900011083 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900011084 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 226900011085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900011086 motif II; other site 226900011087 manganese transport transcriptional regulator; Provisional; Region: PRK03902 226900011088 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 226900011089 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 226900011090 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 226900011091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900011092 FeS/SAM binding site; other site 226900011093 Predicted transcriptional regulators [Transcription]; Region: COG1695 226900011094 hypothetical protein; Validated; Region: PRK07668 226900011095 ribonuclease E; Reviewed; Region: rne; PRK10811 226900011096 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 226900011097 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900011098 active site residue [active] 226900011099 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900011100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900011101 DNA binding site [nucleotide binding] 226900011102 domain linker motif; other site 226900011103 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226900011104 putative dimerization interface [polypeptide binding]; other site 226900011105 putative ligand binding site [chemical binding]; other site 226900011106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900011107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900011108 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 226900011109 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 226900011110 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 226900011111 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 226900011112 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 226900011113 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 226900011114 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 226900011115 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900011116 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900011117 Walker A/P-loop; other site 226900011118 ATP binding site [chemical binding]; other site 226900011119 Q-loop/lid; other site 226900011120 ABC transporter signature motif; other site 226900011121 Walker B; other site 226900011122 D-loop; other site 226900011123 H-loop/switch region; other site 226900011124 Predicted transcriptional regulators [Transcription]; Region: COG1725 226900011125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900011126 DNA-binding site [nucleotide binding]; DNA binding site 226900011127 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 226900011128 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 226900011129 tetramer interface [polypeptide binding]; other site 226900011130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900011131 catalytic residue [active] 226900011132 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 226900011133 tetramer interface [polypeptide binding]; other site 226900011134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900011135 catalytic residue [active] 226900011136 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 226900011137 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 226900011138 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 226900011139 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 226900011140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900011141 ATP binding site [chemical binding]; other site 226900011142 putative Mg++ binding site [ion binding]; other site 226900011143 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 226900011144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900011145 nucleotide binding region [chemical binding]; other site 226900011146 ATP-binding site [chemical binding]; other site 226900011147 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 226900011148 YqzE-like protein; Region: YqzE; pfam14038 226900011149 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 226900011150 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 226900011151 ADP binding site [chemical binding]; other site 226900011152 magnesium binding site [ion binding]; other site 226900011153 putative shikimate binding site; other site 226900011154 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 226900011155 ComG operon protein 7; Region: ComGG; pfam14173 226900011156 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 226900011157 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 226900011158 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 226900011159 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 226900011160 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 226900011161 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 226900011162 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 226900011163 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 226900011164 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 226900011165 Walker A motif; other site 226900011166 ATP binding site [chemical binding]; other site 226900011167 Walker B motif; other site 226900011168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900011169 putative DNA binding site [nucleotide binding]; other site 226900011170 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 226900011171 putative Zn2+ binding site [ion binding]; other site 226900011172 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 226900011173 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 226900011174 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 226900011175 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 226900011176 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 226900011177 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226900011178 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 226900011179 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 226900011180 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 226900011181 active site 226900011182 homodimer interface [polypeptide binding]; other site 226900011183 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 226900011184 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 226900011185 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 226900011186 substrate binding pocket [chemical binding]; other site 226900011187 dimer interface [polypeptide binding]; other site 226900011188 inhibitor binding site; inhibition site 226900011189 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 226900011190 B12 binding site [chemical binding]; other site 226900011191 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 226900011192 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 226900011193 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 226900011194 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 226900011195 FAD binding site [chemical binding]; other site 226900011196 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900011197 homodimer interface [polypeptide binding]; other site 226900011198 substrate-cofactor binding pocket; other site 226900011199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900011200 catalytic residue [active] 226900011201 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900011202 homodimer interface [polypeptide binding]; other site 226900011203 substrate-cofactor binding pocket; other site 226900011204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900011205 catalytic residue [active] 226900011206 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 226900011207 catalytic triad [active] 226900011208 conserved cis-peptide bond; other site 226900011209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900011210 dimerization interface [polypeptide binding]; other site 226900011211 putative DNA binding site [nucleotide binding]; other site 226900011212 putative Zn2+ binding site [ion binding]; other site 226900011213 Uncharacterized conserved protein [Function unknown]; Region: COG1565 226900011214 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 226900011215 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 226900011216 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 226900011217 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 226900011218 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 226900011219 nucleotide binding site [chemical binding]; other site 226900011220 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 226900011221 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 226900011222 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 226900011223 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 226900011224 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 226900011225 active site 226900011226 Substrate binding site; other site 226900011227 Mg++ binding site; other site 226900011228 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 226900011229 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 226900011230 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 226900011231 active site 226900011232 metal binding site [ion binding]; metal-binding site 226900011233 substrate binding site [chemical binding]; other site 226900011234 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 226900011235 PhoU domain; Region: PhoU; pfam01895 226900011236 PhoU domain; Region: PhoU; pfam01895 226900011237 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 226900011238 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 226900011239 Walker A/P-loop; other site 226900011240 ATP binding site [chemical binding]; other site 226900011241 Q-loop/lid; other site 226900011242 ABC transporter signature motif; other site 226900011243 Walker B; other site 226900011244 D-loop; other site 226900011245 H-loop/switch region; other site 226900011246 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 226900011247 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 226900011248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900011249 dimer interface [polypeptide binding]; other site 226900011250 conserved gate region; other site 226900011251 putative PBP binding loops; other site 226900011252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 226900011253 ABC-ATPase subunit interface; other site 226900011254 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 226900011255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900011256 dimer interface [polypeptide binding]; other site 226900011257 conserved gate region; other site 226900011258 putative PBP binding loops; other site 226900011259 ABC-ATPase subunit interface; other site 226900011260 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 226900011261 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900011262 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900011263 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900011264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900011265 putative substrate translocation pore; other site 226900011266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900011267 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 226900011268 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 226900011269 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 226900011270 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 226900011271 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 226900011272 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 226900011273 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 226900011274 metal binding site 2 [ion binding]; metal-binding site 226900011275 putative DNA binding helix; other site 226900011276 metal binding site 1 [ion binding]; metal-binding site 226900011277 dimer interface [polypeptide binding]; other site 226900011278 structural Zn2+ binding site [ion binding]; other site 226900011279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900011280 ABC-ATPase subunit interface; other site 226900011281 dimer interface [polypeptide binding]; other site 226900011282 putative PBP binding regions; other site 226900011283 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 226900011284 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 226900011285 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900011286 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226900011287 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 226900011288 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 226900011289 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 226900011290 AP (apurinic/apyrimidinic) site pocket; other site 226900011291 DNA interaction; other site 226900011292 Metal-binding active site; metal-binding site 226900011293 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226900011294 DEAD-like helicases superfamily; Region: DEXDc; smart00487 226900011295 ATP binding site [chemical binding]; other site 226900011296 Mg++ binding site [ion binding]; other site 226900011297 motif III; other site 226900011298 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900011299 nucleotide binding region [chemical binding]; other site 226900011300 ATP-binding site [chemical binding]; other site 226900011301 YqfQ-like protein; Region: YqfQ; pfam14181 226900011302 similar to LytB protein 226900011303 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 226900011304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 226900011305 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 226900011306 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 226900011307 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 226900011308 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 226900011309 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 226900011310 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 226900011311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900011312 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 226900011313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900011314 DNA binding residues [nucleotide binding] 226900011315 DNA primase; Validated; Region: dnaG; PRK05667 226900011316 CHC2 zinc finger; Region: zf-CHC2; pfam01807 226900011317 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 226900011318 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 226900011319 active site 226900011320 metal binding site [ion binding]; metal-binding site 226900011321 interdomain interaction site; other site 226900011322 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 226900011323 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 226900011324 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 226900011325 PEP synthetase regulatory protein; Provisional; Region: PRK05339 226900011326 HTH domain; Region: HTH_11; pfam08279 226900011327 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 226900011328 FOG: CBS domain [General function prediction only]; Region: COG0517 226900011329 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 226900011330 Recombination protein O N terminal; Region: RecO_N; pfam11967 226900011331 Recombination protein O C terminal; Region: RecO_C; pfam02565 226900011332 YqzL-like protein; Region: YqzL; pfam14006 226900011333 GTPase Era; Reviewed; Region: era; PRK00089 226900011334 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 226900011335 G1 box; other site 226900011336 GTP/Mg2+ binding site [chemical binding]; other site 226900011337 Switch I region; other site 226900011338 G2 box; other site 226900011339 Switch II region; other site 226900011340 G3 box; other site 226900011341 G4 box; other site 226900011342 G5 box; other site 226900011343 KH domain; Region: KH_2; pfam07650 226900011344 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 226900011345 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 226900011346 active site 226900011347 catalytic motif [active] 226900011348 Zn binding site [ion binding]; other site 226900011349 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 226900011350 trimer interface [polypeptide binding]; other site 226900011351 putative active site [active] 226900011352 Zn binding site [ion binding]; other site 226900011353 metal-binding heat shock protein; Provisional; Region: PRK00016 226900011354 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 226900011355 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 226900011356 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 226900011357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900011358 Zn2+ binding site [ion binding]; other site 226900011359 Mg2+ binding site [ion binding]; other site 226900011360 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 226900011361 PhoH-like protein; Region: PhoH; pfam02562 226900011362 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 226900011363 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 226900011364 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 226900011365 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 226900011366 Yqey-like protein; Region: YqeY; pfam09424 226900011367 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 226900011368 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 226900011369 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 226900011370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900011371 FeS/SAM binding site; other site 226900011372 TRAM domain; Region: TRAM; cl01282 226900011373 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 226900011374 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 226900011375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900011376 S-adenosylmethionine binding site [chemical binding]; other site 226900011377 chaperone protein DnaJ; Provisional; Region: PRK14280 226900011378 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 226900011379 HSP70 interaction site [polypeptide binding]; other site 226900011380 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 226900011381 substrate binding site [polypeptide binding]; other site 226900011382 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 226900011383 Zn binding sites [ion binding]; other site 226900011384 dimer interface [polypeptide binding]; other site 226900011385 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 226900011386 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 226900011387 nucleotide binding site [chemical binding]; other site 226900011388 NEF interaction site [polypeptide binding]; other site 226900011389 SBD interface [polypeptide binding]; other site 226900011390 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 226900011391 dimer interface [polypeptide binding]; other site 226900011392 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 226900011393 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 226900011394 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 226900011395 HrcA protein C terminal domain; Region: HrcA; pfam01628 226900011396 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 226900011397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900011398 FeS/SAM binding site; other site 226900011399 HemN C-terminal domain; Region: HemN_C; pfam06969 226900011400 Predicted transcriptional regulators [Transcription]; Region: COG1733 226900011401 dimerization interface [polypeptide binding]; other site 226900011402 putative DNA binding site [nucleotide binding]; other site 226900011403 putative Zn2+ binding site [ion binding]; other site 226900011404 GTP-binding protein LepA; Provisional; Region: PRK05433 226900011405 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 226900011406 G1 box; other site 226900011407 putative GEF interaction site [polypeptide binding]; other site 226900011408 GTP/Mg2+ binding site [chemical binding]; other site 226900011409 Switch I region; other site 226900011410 G2 box; other site 226900011411 G3 box; other site 226900011412 Switch II region; other site 226900011413 G4 box; other site 226900011414 G5 box; other site 226900011415 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 226900011416 Elongation Factor G, domain II; Region: EFG_II; pfam14492 226900011417 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 226900011418 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 226900011419 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 226900011420 germination protease; Provisional; Region: PRK02858 226900011421 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 226900011422 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 226900011423 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 226900011424 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 226900011425 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 226900011426 Competence protein; Region: Competence; pfam03772 226900011427 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900011428 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 226900011429 catalytic motif [active] 226900011430 Zn binding site [ion binding]; other site 226900011431 SLBB domain; Region: SLBB; pfam10531 226900011432 comEA protein; Region: comE; TIGR01259 226900011433 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 226900011434 late competence protein ComER; Validated; Region: PRK07680 226900011435 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 226900011436 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 226900011437 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 226900011438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900011439 S-adenosylmethionine binding site [chemical binding]; other site 226900011440 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 226900011441 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 226900011442 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900011443 Zn2+ binding site [ion binding]; other site 226900011444 Mg2+ binding site [ion binding]; other site 226900011445 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 226900011446 active site 226900011447 (T/H)XGH motif; other site 226900011448 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 226900011449 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 226900011450 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 226900011451 shikimate binding site; other site 226900011452 NAD(P) binding site [chemical binding]; other site 226900011453 GTPase YqeH; Provisional; Region: PRK13796 226900011454 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 226900011455 GTP/Mg2+ binding site [chemical binding]; other site 226900011456 G4 box; other site 226900011457 G5 box; other site 226900011458 G1 box; other site 226900011459 Switch I region; other site 226900011460 G2 box; other site 226900011461 G3 box; other site 226900011462 Switch II region; other site 226900011463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900011464 active site 226900011465 motif I; other site 226900011466 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 226900011467 motif II; other site 226900011468 Sporulation inhibitor A; Region: Sda; pfam08970 226900011469 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 226900011470 sporulation sigma factor SigK; Reviewed; Region: PRK05803 226900011471 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900011472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900011473 DNA binding residues [nucleotide binding] 226900011474 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900011475 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 226900011476 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 226900011477 dimer interface [polypeptide binding]; other site 226900011478 FMN binding site [chemical binding]; other site 226900011479 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226900011480 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 226900011481 synthetase active site [active] 226900011482 NTP binding site [chemical binding]; other site 226900011483 metal binding site [ion binding]; metal-binding site 226900011484 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 226900011485 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 226900011486 dimer interface [polypeptide binding]; other site 226900011487 active site 226900011488 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 226900011489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900011490 Coenzyme A binding pocket [chemical binding]; other site 226900011491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900011492 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900011493 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900011494 Predicted membrane protein [Function unknown]; Region: COG2259 226900011495 CHAT domain; Region: CHAT; cl19248 226900011496 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 226900011497 catalytic core [active] 226900011498 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 226900011499 translocation protein TolB; Provisional; Region: tolB; PRK04792 226900011500 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 226900011501 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 226900011502 Subtilase family; Region: Peptidase_S8; pfam00082 226900011503 catalytic triad [active] 226900011504 putative active site [active] 226900011505 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 226900011506 PA/protease or protease-like domain interface [polypeptide binding]; other site 226900011507 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 226900011508 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 226900011509 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 226900011510 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 226900011511 cofactor binding site; other site 226900011512 metal binding site [ion binding]; metal-binding site 226900011513 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 226900011514 aromatic arch; other site 226900011515 DCoH dimer interaction site [polypeptide binding]; other site 226900011516 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 226900011517 DCoH tetramer interaction site [polypeptide binding]; other site 226900011518 substrate binding site [chemical binding]; other site 226900011519 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 226900011520 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 226900011521 putative metal binding site [ion binding]; other site 226900011522 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 226900011523 active site 226900011524 Predicted membrane protein [Function unknown]; Region: COG2259 226900011525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900011526 non-specific DNA binding site [nucleotide binding]; other site 226900011527 salt bridge; other site 226900011528 sequence-specific DNA binding site [nucleotide binding]; other site 226900011529 Cupin domain; Region: Cupin_2; pfam07883 226900011530 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 226900011531 active site 2 [active] 226900011532 active site 1 [active] 226900011533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900011534 Coenzyme A binding pocket [chemical binding]; other site 226900011535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900011536 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900011537 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226900011538 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226900011539 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900011540 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900011541 Walker A/P-loop; other site 226900011542 ATP binding site [chemical binding]; other site 226900011543 Q-loop/lid; other site 226900011544 ABC transporter signature motif; other site 226900011545 Walker B; other site 226900011546 D-loop; other site 226900011547 H-loop/switch region; other site 226900011548 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900011549 ABC-ATPase subunit interface; other site 226900011550 dimer interface [polypeptide binding]; other site 226900011551 putative PBP binding regions; other site 226900011552 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 226900011553 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900011554 intersubunit interface [polypeptide binding]; other site 226900011555 YrhC-like protein; Region: YrhC; pfam14143 226900011556 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 226900011557 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 226900011558 putative catalytic cysteine [active] 226900011559 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 226900011560 putative active site [active] 226900011561 metal binding site [ion binding]; metal-binding site 226900011562 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900011563 homodimer interface [polypeptide binding]; other site 226900011564 substrate-cofactor binding pocket; other site 226900011565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900011566 catalytic residue [active] 226900011567 cysteine synthase; Region: PLN02565 226900011568 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 226900011569 dimer interface [polypeptide binding]; other site 226900011570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900011571 catalytic residue [active] 226900011572 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 226900011573 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900011574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900011575 S-adenosylmethionine binding site [chemical binding]; other site 226900011576 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 226900011577 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 226900011578 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 226900011579 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 226900011580 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900011581 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 226900011582 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 226900011583 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 226900011584 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 226900011585 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 226900011586 ATP-binding site [chemical binding]; other site 226900011587 Sugar specificity; other site 226900011588 Pyrimidine base specificity; other site 226900011589 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 226900011590 putative protease; Provisional; Region: PRK15452 226900011591 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 226900011592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900011593 S-adenosylmethionine binding site [chemical binding]; other site 226900011594 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 226900011595 dimerization interface [polypeptide binding]; other site 226900011596 hypothetical protein; Provisional; Region: PRK13678 226900011597 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 226900011598 hypothetical protein; Provisional; Region: PRK05473 226900011599 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 226900011600 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 226900011601 motif 1; other site 226900011602 active site 226900011603 motif 2; other site 226900011604 motif 3; other site 226900011605 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 226900011606 DHHA1 domain; Region: DHHA1; pfam02272 226900011607 Bacterial PH domain; Region: bPH_3; pfam14470 226900011608 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226900011609 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 226900011610 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 226900011611 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 226900011612 AAA domain; Region: AAA_30; pfam13604 226900011613 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226900011614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900011615 TPR motif; other site 226900011616 TPR repeat; Region: TPR_11; pfam13414 226900011617 binding surface 226900011618 TPR repeat; Region: TPR_11; pfam13414 226900011619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900011620 binding surface 226900011621 TPR motif; other site 226900011622 TPR repeat; Region: TPR_11; pfam13414 226900011623 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 226900011624 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 226900011625 Ligand Binding Site [chemical binding]; other site 226900011626 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 226900011627 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900011628 catalytic residue [active] 226900011629 Predicted transcriptional regulator [Transcription]; Region: COG1959 226900011630 Rrf2 family protein; Region: rrf2_super; TIGR00738 226900011631 recombination factor protein RarA; Reviewed; Region: PRK13342 226900011632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011633 Walker A motif; other site 226900011634 ATP binding site [chemical binding]; other site 226900011635 Walker B motif; other site 226900011636 arginine finger; other site 226900011637 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 226900011638 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 226900011639 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 226900011640 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 226900011641 putative ATP binding site [chemical binding]; other site 226900011642 putative substrate interface [chemical binding]; other site 226900011643 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 226900011644 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 226900011645 dimer interface [polypeptide binding]; other site 226900011646 anticodon binding site; other site 226900011647 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 226900011648 homodimer interface [polypeptide binding]; other site 226900011649 motif 1; other site 226900011650 active site 226900011651 motif 2; other site 226900011652 GAD domain; Region: GAD; pfam02938 226900011653 motif 3; other site 226900011654 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 226900011655 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 226900011656 dimer interface [polypeptide binding]; other site 226900011657 motif 1; other site 226900011658 active site 226900011659 motif 2; other site 226900011660 motif 3; other site 226900011661 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 226900011662 anticodon binding site; other site 226900011663 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 226900011664 putative active site [active] 226900011665 dimerization interface [polypeptide binding]; other site 226900011666 putative tRNAtyr binding site [nucleotide binding]; other site 226900011667 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 226900011668 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900011669 Zn2+ binding site [ion binding]; other site 226900011670 Mg2+ binding site [ion binding]; other site 226900011671 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 226900011672 synthetase active site [active] 226900011673 NTP binding site [chemical binding]; other site 226900011674 metal binding site [ion binding]; metal-binding site 226900011675 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 226900011676 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 226900011677 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900011678 active site 226900011679 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 226900011680 DHH family; Region: DHH; pfam01368 226900011681 DHHA1 domain; Region: DHHA1; pfam02272 226900011682 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 226900011683 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 226900011684 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 226900011685 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 226900011686 MMPL family; Region: MMPL; cl14618 226900011687 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 226900011688 Protein export membrane protein; Region: SecD_SecF; pfam02355 226900011689 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 226900011690 stage V sporulation protein B; Region: spore_V_B; TIGR02900 226900011691 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 226900011692 Predicted membrane protein [Function unknown]; Region: COG2323 226900011693 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 226900011694 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 226900011695 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 226900011696 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 226900011697 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 226900011698 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 226900011699 Holliday junction DNA helicase, RuvB subunit; Region: ruvB; TIGR00635 226900011700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011701 Walker A motif; other site 226900011702 ATP binding site [chemical binding]; other site 226900011703 Walker B motif; other site 226900011704 arginine finger; other site 226900011705 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 226900011706 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 226900011707 RuvA N terminal domain; Region: RuvA_N; pfam01330 226900011708 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 226900011709 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 226900011710 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900011711 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 226900011712 putative ligand binding residues [chemical binding]; other site 226900011713 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 226900011714 BofC C-terminal domain; Region: BofC_C; pfam08955 226900011715 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 226900011716 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 226900011717 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226900011718 quinolinate synthetase; Provisional; Region: PRK09375 226900011719 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 226900011720 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 226900011721 dimerization interface [polypeptide binding]; other site 226900011722 active site 226900011723 L-aspartate oxidase; Provisional; Region: PRK08071 226900011724 L-aspartate oxidase; Provisional; Region: PRK06175 226900011725 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 226900011726 cysteine desulfurase; Provisional; Region: PRK02948 226900011727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900011728 catalytic residue [active] 226900011729 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 226900011730 HTH domain; Region: HTH_11; pfam08279 226900011731 3H domain; Region: 3H; pfam02829 226900011732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 226900011733 MOSC domain; Region: MOSC; pfam03473 226900011734 3-alpha domain; Region: 3-alpha; pfam03475 226900011735 prephenate dehydratase; Provisional; Region: PRK11898 226900011736 Prephenate dehydratase; Region: PDT; pfam00800 226900011737 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 226900011738 putative L-Phe binding site [chemical binding]; other site 226900011739 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900011740 FtsX-like permease family; Region: FtsX; pfam02687 226900011741 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 226900011742 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900011743 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900011744 Walker A/P-loop; other site 226900011745 ATP binding site [chemical binding]; other site 226900011746 Q-loop/lid; other site 226900011747 ABC transporter signature motif; other site 226900011748 Walker B; other site 226900011749 D-loop; other site 226900011750 H-loop/switch region; other site 226900011751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900011752 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 226900011753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900011754 ATP binding site [chemical binding]; other site 226900011755 Mg2+ binding site [ion binding]; other site 226900011756 G-X-G motif; other site 226900011757 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900011758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900011759 active site 226900011760 phosphorylation site [posttranslational modification] 226900011761 intermolecular recognition site; other site 226900011762 dimerization interface [polypeptide binding]; other site 226900011763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900011764 DNA binding site [nucleotide binding] 226900011765 GTPase CgtA; Reviewed; Region: obgE; PRK12297 226900011766 GTP1/OBG; Region: GTP1_OBG; pfam01018 226900011767 Obg GTPase; Region: Obg; cd01898 226900011768 G1 box; other site 226900011769 GTP/Mg2+ binding site [chemical binding]; other site 226900011770 Switch I region; other site 226900011771 G2 box; other site 226900011772 G3 box; other site 226900011773 Switch II region; other site 226900011774 G4 box; other site 226900011775 G5 box; other site 226900011776 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 226900011777 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 226900011778 Sporulation initiation phospho-transferase B, C-terminal; Region: SPOB_ab; pfam14682 226900011779 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 226900011780 hypothetical protein; Provisional; Region: PRK14553 226900011781 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 226900011782 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 226900011783 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 226900011784 homodimer interface [polypeptide binding]; other site 226900011785 oligonucleotide binding site [chemical binding]; other site 226900011786 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 226900011787 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 226900011788 Peptidase family M50; Region: Peptidase_M50; pfam02163 226900011789 active site 226900011790 putative substrate binding region [chemical binding]; other site 226900011791 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226900011792 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900011793 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 226900011794 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 226900011795 P-loop; other site 226900011796 ADP binding residues [chemical binding]; other site 226900011797 Switch I; other site 226900011798 Switch II; other site 226900011799 septum formation inhibitor; Reviewed; Region: minC; PRK00513 226900011800 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 226900011801 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 226900011802 rod shape-determining protein MreC; Provisional; Region: PRK13922 226900011803 rod shape-determining protein MreB; Provisional; Region: PRK13927 226900011804 MreB and similar proteins; Region: MreB_like; cd10225 226900011805 nucleotide binding site [chemical binding]; other site 226900011806 Mg binding site [ion binding]; other site 226900011807 putative protofilament interaction site [polypeptide binding]; other site 226900011808 RodZ interaction site [polypeptide binding]; other site 226900011809 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 226900011810 Flp recombinase, C-terminal catalytic domain. Yeast Flp-like recombinases mediate the amplification of the 2 micron circular plasmid copy number by catalyzing the intra-molecular recombination between two inverted repeats during replication. They...; Region: INT_Flp; cd00217 226900011811 tetramerization interface [polypeptide binding]; other site 226900011812 active site 226900011813 DNA binding site [nucleotide binding] 226900011814 Int/Topo IB signature motif; other site 226900011815 catalytic residues [active] 226900011816 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 226900011817 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 226900011818 active site 226900011819 catalytic residues [active] 226900011820 DNA binding site [nucleotide binding] 226900011821 Int/Topo IB signature motif; other site 226900011822 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 226900011823 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 226900011824 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 226900011825 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 226900011826 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 226900011827 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 226900011828 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900011829 ATP binding site [chemical binding]; other site 226900011830 putative Mg++ binding site [ion binding]; other site 226900011831 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 226900011832 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226900011833 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226900011834 HsdM N-terminal domain; Region: HsdM_N; pfam12161 226900011835 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 226900011836 Methyltransferase domain; Region: Methyltransf_26; pfam13659 226900011837 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 226900011838 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 226900011839 hypothetical protein; Reviewed; Region: PRK00024 226900011840 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 226900011841 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 226900011842 active site 226900011843 dimer interface [polypeptide binding]; other site 226900011844 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 226900011845 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226900011846 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900011847 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 226900011848 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 226900011849 active site 226900011850 HIGH motif; other site 226900011851 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 226900011852 KMSKS motif; other site 226900011853 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 226900011854 tRNA binding surface [nucleotide binding]; other site 226900011855 anticodon binding site; other site 226900011856 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 226900011857 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 226900011858 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 226900011859 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 226900011860 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 226900011861 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 226900011862 inhibitor-cofactor binding pocket; inhibition site 226900011863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900011864 catalytic residue [active] 226900011865 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 226900011866 dimer interface [polypeptide binding]; other site 226900011867 active site 226900011868 Schiff base residues; other site 226900011869 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 226900011870 active site 226900011871 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 226900011872 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 226900011873 domain interfaces; other site 226900011874 active site 226900011875 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 226900011876 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 226900011877 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 226900011878 tRNA; other site 226900011879 putative tRNA binding site [nucleotide binding]; other site 226900011880 putative NADP binding site [chemical binding]; other site 226900011881 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 226900011882 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900011883 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900011884 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 226900011885 Predicted GTPase [General function prediction only]; Region: COG0218 226900011886 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 226900011887 G1 box; other site 226900011888 GTP/Mg2+ binding site [chemical binding]; other site 226900011889 Switch I region; other site 226900011890 G2 box; other site 226900011891 G3 box; other site 226900011892 Switch II region; other site 226900011893 G4 box; other site 226900011894 G5 box; other site 226900011895 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 226900011896 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 226900011897 Golgi complex component 7 (COG7); Region: COG7; pfam10191 226900011898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011899 Walker A motif; other site 226900011900 ATP binding site [chemical binding]; other site 226900011901 Walker B motif; other site 226900011902 arginine finger; other site 226900011903 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 226900011904 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 226900011905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011906 Walker A motif; other site 226900011907 ATP binding site [chemical binding]; other site 226900011908 Walker B motif; other site 226900011909 arginine finger; other site 226900011910 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 226900011911 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 226900011912 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 226900011913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900011914 Walker A motif; other site 226900011915 ATP binding site [chemical binding]; other site 226900011916 Walker B motif; other site 226900011917 arginine finger; other site 226900011918 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 226900011919 trigger factor; Provisional; Region: tig; PRK01490 226900011920 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 226900011921 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 226900011922 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 226900011923 Bacterial PH domain; Region: bPH_1; pfam08000 226900011924 YvbH-like oligomerization region; Region: YvbH_ext; pfam11724 226900011925 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 226900011926 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 226900011927 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 226900011928 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 226900011929 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 226900011930 active site 226900011931 metal binding site [ion binding]; metal-binding site 226900011932 homotetramer interface [polypeptide binding]; other site 226900011933 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 226900011934 active site 226900011935 dimerization interface [polypeptide binding]; other site 226900011936 ribonuclease PH; Reviewed; Region: rph; PRK00173 226900011937 Ribonuclease PH; Region: RNase_PH_bact; cd11362 226900011938 hexamer interface [polypeptide binding]; other site 226900011939 active site 226900011940 Sporulation and spore germination; Region: Germane; pfam10646 226900011941 Spore germination protein [General function prediction only]; Region: COG5401 226900011942 Sporulation and spore germination; Region: Germane; pfam10646 226900011943 glutamate racemase; Provisional; Region: PRK00865 226900011944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900011945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900011946 putative substrate translocation pore; other site 226900011947 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 226900011948 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 226900011949 potential catalytic triad [active] 226900011950 conserved cys residue [active] 226900011951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900011952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900011953 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 226900011954 intracellular protease, PfpI family; Region: PfpI; TIGR01382 226900011955 potential catalytic triad [active] 226900011956 conserved cys residue [active] 226900011957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900011958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900011959 DNA binding residues [nucleotide binding] 226900011960 dimerization interface [polypeptide binding]; other site 226900011961 Sulfate transporter family; Region: Sulfate_transp; cl19250 226900011962 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 226900011963 cytosine deaminase; Provisional; Region: PRK05985 226900011964 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 226900011965 active site 226900011966 PspC domain; Region: PspC; pfam04024 226900011967 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900011968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900011969 non-specific DNA binding site [nucleotide binding]; other site 226900011970 salt bridge; other site 226900011971 sequence-specific DNA binding site [nucleotide binding]; other site 226900011972 Cupin domain; Region: Cupin_2; pfam07883 226900011973 similar to hypothetical protein 226900011974 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 226900011975 amphipathic channel; other site 226900011976 Asn-Pro-Ala signature motifs; other site 226900011977 Predicted transcriptional regulator [Transcription]; Region: COG1959 226900011978 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 226900011979 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 226900011980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900011981 Walker A/P-loop; other site 226900011982 ATP binding site [chemical binding]; other site 226900011983 Q-loop/lid; other site 226900011984 ABC transporter signature motif; other site 226900011985 Walker B; other site 226900011986 D-loop; other site 226900011987 H-loop/switch region; other site 226900011988 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 226900011989 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 226900011990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900011991 active site 226900011992 motif I; other site 226900011993 motif II; other site 226900011994 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 226900011995 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 226900011996 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 226900011997 ligand binding site [chemical binding]; other site 226900011998 flagellar motor protein MotA; Validated; Region: PRK08124 226900011999 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 226900012000 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 226900012001 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 226900012002 active site 226900012003 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 226900012004 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 226900012005 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226900012006 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 226900012007 L-aspartate oxidase; Provisional; Region: PRK06175 226900012008 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 226900012009 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 226900012010 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 226900012011 putative Iron-sulfur protein interface [polypeptide binding]; other site 226900012012 proximal heme binding site [chemical binding]; other site 226900012013 distal heme binding site [chemical binding]; other site 226900012014 putative dimer interface [polypeptide binding]; other site 226900012015 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 226900012016 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 226900012017 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 226900012018 GIY-YIG motif/motif A; other site 226900012019 active site 226900012020 catalytic site [active] 226900012021 putative DNA binding site [nucleotide binding]; other site 226900012022 metal binding site [ion binding]; metal-binding site 226900012023 Cytochrome P450; Region: p450; cl12078 226900012024 UvrB/uvrC motif; Region: UVR; pfam02151 226900012025 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 226900012026 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 226900012027 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900012028 catalytic residues [active] 226900012029 similar to Electron transfer flavoprotein alpha-subunit 226900012030 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 226900012031 Ligand binding site [chemical binding]; other site 226900012032 enoyl-CoA hydratase; Provisional; Region: PRK07658 226900012033 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900012034 substrate binding site [chemical binding]; other site 226900012035 oxyanion hole (OAH) forming residues; other site 226900012036 trimer interface [polypeptide binding]; other site 226900012037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900012038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900012039 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 226900012040 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 226900012041 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 226900012042 acyl-activating enzyme (AAE) consensus motif; other site 226900012043 putative AMP binding site [chemical binding]; other site 226900012044 putative active site [active] 226900012045 putative CoA binding site [chemical binding]; other site 226900012046 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012047 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 226900012048 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 226900012049 siderophore binding site; other site 226900012050 similar to Transporter 226900012051 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 226900012052 DinB family; Region: DinB; cl17821 226900012053 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 226900012054 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 226900012055 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 226900012056 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 226900012057 Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993 226900012058 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900012059 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 226900012060 Walker A/P-loop; other site 226900012061 ATP binding site [chemical binding]; other site 226900012062 Q-loop/lid; other site 226900012063 ABC transporter signature motif; other site 226900012064 Walker B; other site 226900012065 D-loop; other site 226900012066 H-loop/switch region; other site 226900012067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900012068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900012069 dimer interface [polypeptide binding]; other site 226900012070 phosphorylation site [posttranslational modification] 226900012071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012072 ATP binding site [chemical binding]; other site 226900012073 Mg2+ binding site [ion binding]; other site 226900012074 G-X-G motif; other site 226900012075 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012077 active site 226900012078 phosphorylation site [posttranslational modification] 226900012079 intermolecular recognition site; other site 226900012080 dimerization interface [polypeptide binding]; other site 226900012081 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900012082 DNA binding site [nucleotide binding] 226900012083 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 226900012084 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 226900012085 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 226900012086 putative RNA binding site [nucleotide binding]; other site 226900012087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 226900012088 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 226900012089 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 226900012090 active site 226900012091 catalytic site [active] 226900012092 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900012093 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900012094 Walker A/P-loop; other site 226900012095 ATP binding site [chemical binding]; other site 226900012096 Q-loop/lid; other site 226900012097 ABC transporter signature motif; other site 226900012098 Walker B; other site 226900012099 D-loop; other site 226900012100 H-loop/switch region; other site 226900012101 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900012102 ABC-ATPase subunit interface; other site 226900012103 dimer interface [polypeptide binding]; other site 226900012104 putative PBP binding regions; other site 226900012105 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 226900012106 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900012107 intersubunit interface [polypeptide binding]; other site 226900012108 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900012109 heme-binding site [chemical binding]; other site 226900012110 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900012111 heme-binding site [chemical binding]; other site 226900012112 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900012113 heme-binding site [chemical binding]; other site 226900012114 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900012115 heme-binding site [chemical binding]; other site 226900012116 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900012117 heme-binding site [chemical binding]; other site 226900012118 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900012119 heme-binding site [chemical binding]; other site 226900012120 heme uptake protein IsdC; Region: IsdC; TIGR03656 226900012121 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 226900012122 heme-binding site [chemical binding]; other site 226900012123 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 226900012124 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 226900012125 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 226900012126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900012127 RNA binding surface [nucleotide binding]; other site 226900012128 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 226900012129 probable active site [active] 226900012130 similar to DNA mismatch repair protein mutS 226900012131 hypothetical protein; Provisional; Region: PRK08609 226900012132 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 226900012133 active site 226900012134 primer binding site [nucleotide binding]; other site 226900012135 NTP binding site [chemical binding]; other site 226900012136 metal binding triad [ion binding]; metal-binding site 226900012137 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 226900012138 active site 226900012139 Colicin V production protein; Region: Colicin_V; pfam02674 226900012140 cell division protein ZapA; Provisional; Region: PRK14126 226900012141 ribonuclease HIII; Provisional; Region: PRK00996 226900012142 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 226900012143 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 226900012144 RNA/DNA hybrid binding site [nucleotide binding]; other site 226900012145 active site 226900012146 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 226900012147 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 226900012148 putative dimer interface [polypeptide binding]; other site 226900012149 putative anticodon binding site; other site 226900012150 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 226900012151 homodimer interface [polypeptide binding]; other site 226900012152 motif 1; other site 226900012153 motif 2; other site 226900012154 active site 226900012155 motif 3; other site 226900012156 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 226900012157 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 226900012158 putative tRNA-binding site [nucleotide binding]; other site 226900012159 B3/4 domain; Region: B3_4; pfam03483 226900012160 tRNA synthetase B5 domain; Region: B5; smart00874 226900012161 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 226900012162 dimer interface [polypeptide binding]; other site 226900012163 motif 1; other site 226900012164 motif 3; other site 226900012165 motif 2; other site 226900012166 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 226900012167 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 226900012168 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 226900012169 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 226900012170 dimer interface [polypeptide binding]; other site 226900012171 motif 1; other site 226900012172 active site 226900012173 motif 2; other site 226900012174 motif 3; other site 226900012175 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 226900012176 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 226900012177 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 226900012178 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 226900012179 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900012180 Zn2+ binding site [ion binding]; other site 226900012181 Mg2+ binding site [ion binding]; other site 226900012182 CAAX protease self-immunity; Region: Abi; pfam02517 226900012183 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 226900012184 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900012185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900012186 putative substrate translocation pore; other site 226900012187 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 226900012188 HlyD family secretion protein; Region: HlyD_3; pfam13437 226900012189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900012190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900012191 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 226900012192 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 226900012193 oligomer interface [polypeptide binding]; other site 226900012194 active site 226900012195 metal binding site [ion binding]; metal-binding site 226900012196 dUTPase; Region: dUTPase_2; pfam08761 226900012197 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 226900012198 active site 226900012199 homodimer interface [polypeptide binding]; other site 226900012200 metal binding site [ion binding]; metal-binding site 226900012201 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 226900012202 23S rRNA binding site [nucleotide binding]; other site 226900012203 L21 binding site [polypeptide binding]; other site 226900012204 L13 binding site [polypeptide binding]; other site 226900012205 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 226900012206 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 226900012207 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 226900012208 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 226900012209 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 226900012210 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 226900012211 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 226900012212 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 226900012213 active site 226900012214 dimer interface [polypeptide binding]; other site 226900012215 motif 1; other site 226900012216 motif 2; other site 226900012217 motif 3; other site 226900012218 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 226900012219 anticodon binding site; other site 226900012220 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 226900012221 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 226900012222 primosomal protein DnaI; Reviewed; Region: PRK08939 226900012223 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 226900012224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900012225 Walker A motif; other site 226900012226 ATP binding site [chemical binding]; other site 226900012227 Walker B motif; other site 226900012228 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 226900012229 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 226900012230 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 226900012231 ATP cone domain; Region: ATP-cone; pfam03477 226900012232 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 226900012233 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 226900012234 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 226900012235 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 226900012236 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 226900012237 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 226900012238 CoA-binding site [chemical binding]; other site 226900012239 ATP-binding [chemical binding]; other site 226900012240 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 226900012241 Domain of unknown function DUF; Region: DUF204; pfam02659 226900012242 Domain of unknown function DUF; Region: DUF204; pfam02659 226900012243 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 226900012244 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 226900012245 DNA binding site [nucleotide binding] 226900012246 catalytic residue [active] 226900012247 H2TH interface [polypeptide binding]; other site 226900012248 putative catalytic residues [active] 226900012249 turnover-facilitating residue; other site 226900012250 intercalation triad [nucleotide binding]; other site 226900012251 8OG recognition residue [nucleotide binding]; other site 226900012252 putative reading head residues; other site 226900012253 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 226900012254 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 226900012255 DNA polymerase I; Provisional; Region: PRK05755 226900012256 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 226900012257 active site 226900012258 metal binding site 1 [ion binding]; metal-binding site 226900012259 putative 5' ssDNA interaction site; other site 226900012260 metal binding site 3; metal-binding site 226900012261 metal binding site 2 [ion binding]; metal-binding site 226900012262 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 226900012263 putative DNA binding site [nucleotide binding]; other site 226900012264 putative metal binding site [ion binding]; other site 226900012265 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 226900012266 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 226900012267 active site 226900012268 DNA binding site [nucleotide binding] 226900012269 catalytic site [active] 226900012270 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 226900012271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900012272 dimerization interface [polypeptide binding]; other site 226900012273 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226900012274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900012275 putative active site [active] 226900012276 heme pocket [chemical binding]; other site 226900012277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900012278 dimer interface [polypeptide binding]; other site 226900012279 phosphorylation site [posttranslational modification] 226900012280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012281 ATP binding site [chemical binding]; other site 226900012282 Mg2+ binding site [ion binding]; other site 226900012283 G-X-G motif; other site 226900012284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012286 active site 226900012287 phosphorylation site [posttranslational modification] 226900012288 intermolecular recognition site; other site 226900012289 dimerization interface [polypeptide binding]; other site 226900012290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900012291 DNA binding site [nucleotide binding] 226900012292 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 226900012293 active site 2 [active] 226900012294 active site 1 [active] 226900012295 malate dehydrogenase; Reviewed; Region: PRK06223 226900012296 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 226900012297 NAD(P) binding site [chemical binding]; other site 226900012298 dimer interface [polypeptide binding]; other site 226900012299 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900012300 substrate binding site [chemical binding]; other site 226900012301 isocitrate dehydrogenase; Reviewed; Region: PRK07006 226900012302 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 226900012303 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 226900012304 dimer interface [polypeptide binding]; other site 226900012305 active site 226900012306 citrylCoA binding site [chemical binding]; other site 226900012307 oxalacetate/citrate binding site [chemical binding]; other site 226900012308 coenzyme A binding site [chemical binding]; other site 226900012309 catalytic triad [active] 226900012310 Protein of unknown function (DUF441); Region: DUF441; pfam04284 226900012311 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 226900012312 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 226900012313 pyruvate kinase; Provisional; Region: PRK06354 226900012314 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 226900012315 domain interfaces; other site 226900012316 active site 226900012317 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 226900012318 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 226900012319 active site 226900012320 ADP/pyrophosphate binding site [chemical binding]; other site 226900012321 dimerization interface [polypeptide binding]; other site 226900012322 allosteric effector site; other site 226900012323 fructose-1,6-bisphosphate binding site; other site 226900012324 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 226900012325 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 226900012326 Transcriptional regulators [Transcription]; Region: FadR; COG2186 226900012327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900012328 DNA-binding site [nucleotide binding]; DNA binding site 226900012329 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 226900012330 Malic enzyme, N-terminal domain; Region: malic; pfam00390 226900012331 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 226900012332 putative NAD(P) binding site [chemical binding]; other site 226900012333 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 226900012334 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 226900012335 active site 226900012336 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 226900012337 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 226900012338 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 226900012339 generic binding surface II; other site 226900012340 generic binding surface I; other site 226900012341 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 226900012342 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 226900012343 DHH family; Region: DHH; pfam01368 226900012344 DHHA1 domain; Region: DHHA1; pfam02272 226900012345 YtpI-like protein; Region: YtpI; pfam14007 226900012346 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 226900012347 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 226900012348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 226900012349 DNA-binding site [nucleotide binding]; DNA binding site 226900012350 DRTGG domain; Region: DRTGG; pfam07085 226900012351 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 226900012352 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 226900012353 active site 2 [active] 226900012354 active site 1 [active] 226900012355 metal-dependent hydrolase; Provisional; Region: PRK00685 226900012356 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 226900012357 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 226900012358 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 226900012359 active site 226900012360 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 226900012361 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 226900012362 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 226900012363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900012364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900012365 Coenzyme A binding pocket [chemical binding]; other site 226900012366 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 226900012367 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 226900012368 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 226900012369 hexamer interface [polypeptide binding]; other site 226900012370 ligand binding site [chemical binding]; other site 226900012371 putative active site [active] 226900012372 NAD(P) binding site [chemical binding]; other site 226900012373 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 226900012374 classical (c) SDRs; Region: SDR_c; cd05233 226900012375 NAD(P) binding site [chemical binding]; other site 226900012376 active site 226900012377 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 226900012378 Ligand Binding Site [chemical binding]; other site 226900012379 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 226900012380 argininosuccinate lyase; Provisional; Region: PRK00855 226900012381 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 226900012382 active sites [active] 226900012383 tetramer interface [polypeptide binding]; other site 226900012384 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 226900012385 ANP binding site [chemical binding]; other site 226900012386 Substrate Binding Site II [chemical binding]; other site 226900012387 Substrate Binding Site I [chemical binding]; other site 226900012388 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900012389 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900012390 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900012391 EcsC protein family; Region: EcsC; pfam12787 226900012392 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 226900012393 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 226900012394 nudix motif; other site 226900012395 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 226900012396 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 226900012397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900012398 S-adenosylmethionine binding site [chemical binding]; other site 226900012399 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 226900012400 dimer interface [polypeptide binding]; other site 226900012401 catalytic triad [active] 226900012402 peroxidatic and resolving cysteines [active] 226900012403 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 226900012404 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 226900012405 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 226900012406 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 226900012407 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 226900012408 active site 226900012409 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 226900012410 dimer interface [polypeptide binding]; other site 226900012411 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 226900012412 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 226900012413 acyl-activating enzyme (AAE) consensus motif; other site 226900012414 AMP binding site [chemical binding]; other site 226900012415 active site 226900012416 CoA binding site [chemical binding]; other site 226900012417 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 226900012418 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 226900012419 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 226900012420 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 226900012421 Ligand Binding Site [chemical binding]; other site 226900012422 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 226900012423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900012424 catalytic residue [active] 226900012425 septation ring formation regulator EzrA; Provisional; Region: PRK04778 226900012426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900012427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900012428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 226900012429 dimerization interface [polypeptide binding]; other site 226900012430 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900012431 EamA-like transporter family; Region: EamA; pfam00892 226900012432 EamA-like transporter family; Region: EamA; pfam00892 226900012433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900012434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900012435 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 226900012436 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900012437 homodimer interface [polypeptide binding]; other site 226900012438 substrate-cofactor binding pocket; other site 226900012439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900012440 catalytic residue [active] 226900012441 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 226900012442 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 226900012443 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900012444 RNA binding surface [nucleotide binding]; other site 226900012445 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 226900012446 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 226900012447 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 226900012448 active site 226900012449 HIGH motif; other site 226900012450 dimer interface [polypeptide binding]; other site 226900012451 KMSKS motif; other site 226900012452 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900012453 RNA binding surface [nucleotide binding]; other site 226900012454 maltose O-acetyltransferase; Provisional; Region: PRK10092 226900012455 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 226900012456 active site 226900012457 substrate binding site [chemical binding]; other site 226900012458 trimer interface [polypeptide binding]; other site 226900012459 CoA binding site [chemical binding]; other site 226900012460 acetyl-CoA synthetase; Provisional; Region: PRK04319 226900012461 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 226900012462 active site 226900012463 acyl-activating enzyme (AAE) consensus motif; other site 226900012464 putative CoA binding site [chemical binding]; other site 226900012465 AMP binding site [chemical binding]; other site 226900012466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900012467 Coenzyme A binding pocket [chemical binding]; other site 226900012468 FOG: CBS domain [General function prediction only]; Region: COG0517 226900012469 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 226900012470 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 226900012471 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 226900012472 active site 226900012473 Zn binding site [ion binding]; other site 226900012474 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900012475 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900012476 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012478 active site 226900012479 phosphorylation site [posttranslational modification] 226900012480 intermolecular recognition site; other site 226900012481 dimerization interface [polypeptide binding]; other site 226900012482 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900012483 DNA binding site [nucleotide binding] 226900012484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900012485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900012486 dimerization interface [polypeptide binding]; other site 226900012487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900012488 dimer interface [polypeptide binding]; other site 226900012489 phosphorylation site [posttranslational modification] 226900012490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012491 ATP binding site [chemical binding]; other site 226900012492 Mg2+ binding site [ion binding]; other site 226900012493 G-X-G motif; other site 226900012494 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226900012495 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 226900012496 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 226900012497 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 226900012498 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 226900012499 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 226900012500 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 226900012501 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 226900012502 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 226900012503 catabolite control protein A; Region: ccpA; TIGR01481 226900012504 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900012505 DNA binding site [nucleotide binding] 226900012506 domain linker motif; other site 226900012507 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 226900012508 dimerization interface [polypeptide binding]; other site 226900012509 effector binding site; other site 226900012510 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 226900012511 Chorismate mutase type II; Region: CM_2; cl00693 226900012512 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 226900012513 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 226900012514 putative dimer interface [polypeptide binding]; other site 226900012515 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 226900012516 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 226900012517 putative dimer interface [polypeptide binding]; other site 226900012518 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 226900012519 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 226900012520 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 226900012521 Bacterial PH domain; Region: bPH_4; pfam06713 226900012522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900012523 Coenzyme A binding pocket [chemical binding]; other site 226900012524 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900012525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900012526 Coenzyme A binding pocket [chemical binding]; other site 226900012527 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 226900012528 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 226900012529 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 226900012530 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 226900012531 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 226900012532 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 226900012533 active site 226900012534 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 226900012535 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 226900012536 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 226900012537 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 226900012538 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 226900012539 active site 226900012540 metal binding site [ion binding]; metal-binding site 226900012541 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 226900012542 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 226900012543 putative tRNA-binding site [nucleotide binding]; other site 226900012544 hypothetical protein; Provisional; Region: PRK13668 226900012545 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900012546 catalytic residues [active] 226900012547 NTPase; Reviewed; Region: PRK03114 226900012548 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 226900012549 oligomer interface [polypeptide binding]; other site 226900012550 active site 226900012551 metal binding site [ion binding]; metal-binding site 226900012552 Predicted small secreted protein [Function unknown]; Region: COG5584 226900012553 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900012554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900012555 S-adenosylmethionine binding site [chemical binding]; other site 226900012556 YtzH-like protein; Region: YtzH; pfam14165 226900012557 Phosphotransferase enzyme family; Region: APH; pfam01636 226900012558 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 226900012559 active site 226900012560 substrate binding site [chemical binding]; other site 226900012561 ATP binding site [chemical binding]; other site 226900012562 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 226900012563 similar to Pullulanase; EC_number 3.2.1.41 226900012564 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 226900012565 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 226900012566 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 226900012567 dipeptidase PepV; Reviewed; Region: PRK07318 226900012568 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 226900012569 active site 226900012570 metal binding site [ion binding]; metal-binding site 226900012571 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 226900012572 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 226900012573 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900012574 RNA binding surface [nucleotide binding]; other site 226900012575 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 226900012576 active site 226900012577 uracil binding [chemical binding]; other site 226900012578 stage V sporulation protein B; Region: spore_V_B; TIGR02900 226900012579 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 226900012580 HI0933-like protein; Region: HI0933_like; pfam03486 226900012581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900012582 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 226900012583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900012584 putative substrate translocation pore; other site 226900012585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900012586 dimerization interface [polypeptide binding]; other site 226900012587 putative DNA binding site [nucleotide binding]; other site 226900012588 putative Zn2+ binding site [ion binding]; other site 226900012589 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 226900012590 putative hydrophobic ligand binding site [chemical binding]; other site 226900012591 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 226900012592 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 226900012593 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 226900012594 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 226900012595 glucose-1-dehydrogenase; Provisional; Region: PRK08936 226900012596 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 226900012597 NAD binding site [chemical binding]; other site 226900012598 homodimer interface [polypeptide binding]; other site 226900012599 active site 226900012600 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 226900012601 Sugar transport protein; Region: Sugar_transport; pfam06800 226900012602 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 226900012603 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 226900012604 MoaE interaction surface [polypeptide binding]; other site 226900012605 MoeB interaction surface [polypeptide binding]; other site 226900012606 thiocarboxylated glycine; other site 226900012607 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 226900012608 MoaE homodimer interface [polypeptide binding]; other site 226900012609 MoaD interaction [polypeptide binding]; other site 226900012610 active site residues [active] 226900012611 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 226900012612 Walker A motif; other site 226900012613 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 226900012614 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 226900012615 dimer interface [polypeptide binding]; other site 226900012616 putative functional site; other site 226900012617 putative MPT binding site; other site 226900012618 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 226900012619 trimer interface [polypeptide binding]; other site 226900012620 dimer interface [polypeptide binding]; other site 226900012621 putative active site [active] 226900012622 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 226900012623 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 226900012624 ATP binding site [chemical binding]; other site 226900012625 substrate interface [chemical binding]; other site 226900012626 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 226900012627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900012628 FeS/SAM binding site; other site 226900012629 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 226900012630 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012631 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012632 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012633 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012634 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012635 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012636 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012637 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012638 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012639 High molecular weight glutenin subunit; Region: Glutenin_hmw; pfam03157 226900012640 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012641 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012642 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012643 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012644 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900012645 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 226900012646 active site residue [active] 226900012647 homoserine O-acetyltransferase; Provisional; Region: PRK06765 226900012648 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 226900012649 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 226900012650 Neuromodulin; Region: Neuromodulin; pfam06614 226900012651 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 226900012652 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 226900012653 Spore germination protein; Region: Spore_permease; pfam03845 226900012654 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 226900012655 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 226900012656 putative nucleotide binding site [chemical binding]; other site 226900012657 putative metal binding site [ion binding]; other site 226900012658 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 226900012659 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 226900012660 active site 226900012661 HIGH motif; other site 226900012662 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 226900012663 KMSKS motif; other site 226900012664 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 226900012665 tRNA binding surface [nucleotide binding]; other site 226900012666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900012667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900012668 putative substrate translocation pore; other site 226900012669 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 226900012670 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 226900012671 TrkA-C domain; Region: TrkA_C; pfam02080 226900012672 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 226900012673 Int/Topo IB signature motif; other site 226900012674 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900012675 FtsX-like permease family; Region: FtsX; pfam02687 226900012676 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900012677 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900012678 Walker A/P-loop; other site 226900012679 ATP binding site [chemical binding]; other site 226900012680 Q-loop/lid; other site 226900012681 ABC transporter signature motif; other site 226900012682 Walker B; other site 226900012683 D-loop; other site 226900012684 H-loop/switch region; other site 226900012685 Predicted membrane protein [Function unknown]; Region: COG2311 226900012686 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 226900012687 Protein of unknown function (DUF418); Region: DUF418; pfam04235 226900012688 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 226900012689 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 226900012690 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900012691 FeS/SAM binding site; other site 226900012692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900012693 S-adenosylmethionine binding site [chemical binding]; other site 226900012694 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 226900012695 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900012696 Walker A/P-loop; other site 226900012697 ATP binding site [chemical binding]; other site 226900012698 Q-loop/lid; other site 226900012699 ABC transporter signature motif; other site 226900012700 Walker B; other site 226900012701 D-loop; other site 226900012702 H-loop/switch region; other site 226900012703 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 226900012704 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 226900012705 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 226900012706 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 226900012707 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 226900012708 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 226900012709 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900012710 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 226900012711 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 226900012712 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 226900012713 trimer interface [polypeptide binding]; other site 226900012714 putative metal binding site [ion binding]; other site 226900012715 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 226900012716 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 226900012717 active site 226900012718 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226900012719 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 226900012720 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 226900012721 GTP binding site; other site 226900012722 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 226900012723 MPT binding site; other site 226900012724 trimer interface [polypeptide binding]; other site 226900012725 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900012726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900012727 Coenzyme A binding pocket [chemical binding]; other site 226900012728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900012729 S-adenosylmethionine synthetase; Validated; Region: PRK05250 226900012730 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 226900012731 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 226900012732 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 226900012733 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 226900012734 active site 226900012735 substrate-binding site [chemical binding]; other site 226900012736 metal-binding site [ion binding] 226900012737 ATP binding site [chemical binding]; other site 226900012738 ATP synthase I chain; Region: ATP_synt_I; pfam03899 226900012739 EamA-like transporter family; Region: EamA; pfam00892 226900012740 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 226900012741 EamA-like transporter family; Region: EamA; pfam00892 226900012742 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 226900012743 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 226900012744 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012745 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 226900012746 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900012747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012748 ATP binding site [chemical binding]; other site 226900012749 Mg2+ binding site [ion binding]; other site 226900012750 G-X-G motif; other site 226900012751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900012752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900012753 dimer interface [polypeptide binding]; other site 226900012754 phosphorylation site [posttranslational modification] 226900012755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012756 ATP binding site [chemical binding]; other site 226900012757 Mg2+ binding site [ion binding]; other site 226900012758 G-X-G motif; other site 226900012759 similar to Catalase; EC_number 1.11.1.6 226900012760 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 226900012761 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900012762 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900012763 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 226900012764 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 226900012765 Sulfatase; Region: Sulfatase; pfam00884 226900012766 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 226900012767 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 226900012768 NMT1-like family; Region: NMT1_2; pfam13379 226900012769 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 226900012770 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 226900012771 Walker A/P-loop; other site 226900012772 ATP binding site [chemical binding]; other site 226900012773 Q-loop/lid; other site 226900012774 ABC transporter signature motif; other site 226900012775 Walker B; other site 226900012776 D-loop; other site 226900012777 H-loop/switch region; other site 226900012778 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 226900012779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900012780 dimer interface [polypeptide binding]; other site 226900012781 conserved gate region; other site 226900012782 putative PBP binding loops; other site 226900012783 ABC-ATPase subunit interface; other site 226900012784 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 226900012785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900012786 motif II; other site 226900012787 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 226900012788 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 226900012789 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 226900012790 nudix motif; other site 226900012791 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 226900012792 S-ribosylhomocysteinase; Provisional; Region: PRK02260 226900012793 hypothetical protein; Validated; Region: PRK00041 226900012794 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 226900012795 active site clefts [active] 226900012796 zinc binding site [ion binding]; other site 226900012797 dimer interface [polypeptide binding]; other site 226900012798 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 226900012799 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 226900012800 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 226900012801 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 226900012802 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 226900012803 putative active site [active] 226900012804 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900012805 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900012806 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226900012807 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 226900012808 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 226900012809 Predicted membrane protein [Function unknown]; Region: COG3766 226900012810 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 226900012811 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 226900012812 hypothetical protein; Provisional; Region: PRK12473 226900012813 Integrase core domain; Region: rve; pfam00665 226900012814 Integrase core domain; Region: rve_2; pfam13333 226900012815 Virus attachment protein p12 family; Region: P12; pfam12669 226900012816 similar to Ferrous iron transport protein B 226900012817 FeoA domain; Region: FeoA; pfam04023 226900012818 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 226900012819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 226900012820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900012821 dimerization interface [polypeptide binding]; other site 226900012822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900012823 dimer interface [polypeptide binding]; other site 226900012824 phosphorylation site [posttranslational modification] 226900012825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012826 ATP binding site [chemical binding]; other site 226900012827 Mg2+ binding site [ion binding]; other site 226900012828 G-X-G motif; other site 226900012829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012831 active site 226900012832 phosphorylation site [posttranslational modification] 226900012833 intermolecular recognition site; other site 226900012834 dimerization interface [polypeptide binding]; other site 226900012835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900012836 DNA binding site [nucleotide binding] 226900012837 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 226900012838 active site 226900012839 catalytic site [active] 226900012840 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900012841 active site 226900012842 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 226900012843 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 226900012844 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 226900012845 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 226900012846 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 226900012847 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 226900012848 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 226900012849 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 226900012850 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900012851 FtsX-like permease family; Region: FtsX; pfam02687 226900012852 FtsX-like permease family; Region: FtsX; pfam02687 226900012853 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 226900012854 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 226900012855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900012856 S-adenosylmethionine binding site [chemical binding]; other site 226900012857 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900012858 FtsX-like permease family; Region: FtsX; pfam02687 226900012859 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900012860 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900012861 Walker A/P-loop; other site 226900012862 ATP binding site [chemical binding]; other site 226900012863 Q-loop/lid; other site 226900012864 ABC transporter signature motif; other site 226900012865 Walker B; other site 226900012866 D-loop; other site 226900012867 H-loop/switch region; other site 226900012868 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 226900012869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 226900012870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 226900012871 Predicted integral membrane protein [Function unknown]; Region: COG5658 226900012872 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 226900012873 SdpI/YhfL protein family; Region: SdpI; pfam13630 226900012874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900012875 dimerization interface [polypeptide binding]; other site 226900012876 putative DNA binding site [nucleotide binding]; other site 226900012877 putative Zn2+ binding site [ion binding]; other site 226900012878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012880 active site 226900012881 phosphorylation site [posttranslational modification] 226900012882 intermolecular recognition site; other site 226900012883 dimerization interface [polypeptide binding]; other site 226900012884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900012885 DNA binding site [nucleotide binding] 226900012886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900012887 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 226900012888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012889 ATP binding site [chemical binding]; other site 226900012890 Mg2+ binding site [ion binding]; other site 226900012891 G-X-G motif; other site 226900012892 FtsX-like permease family; Region: FtsX; pfam02687 226900012893 FtsX-like permease family; Region: FtsX; pfam02687 226900012894 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900012895 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900012896 Walker A/P-loop; other site 226900012897 ATP binding site [chemical binding]; other site 226900012898 Q-loop/lid; other site 226900012899 ABC transporter signature motif; other site 226900012900 Walker B; other site 226900012901 D-loop; other site 226900012902 H-loop/switch region; other site 226900012903 FtsX-like permease family; Region: FtsX; pfam02687 226900012904 GntP family permease; Region: GntP_permease; pfam02447 226900012905 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 226900012906 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 226900012907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 226900012908 DNA-binding site [nucleotide binding]; DNA binding site 226900012909 UTRA domain; Region: UTRA; pfam07702 226900012910 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 226900012911 substrate binding site [chemical binding]; other site 226900012912 ATP binding site [chemical binding]; other site 226900012913 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 226900012914 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 226900012915 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900012916 catalytic residue [active] 226900012917 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 226900012918 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 226900012919 active site 226900012920 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 226900012921 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 226900012922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900012923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900012924 dimerization interface [polypeptide binding]; other site 226900012925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900012926 dimer interface [polypeptide binding]; other site 226900012927 phosphorylation site [posttranslational modification] 226900012928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900012929 ATP binding site [chemical binding]; other site 226900012930 Mg2+ binding site [ion binding]; other site 226900012931 G-X-G motif; other site 226900012932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900012933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900012934 active site 226900012935 phosphorylation site [posttranslational modification] 226900012936 intermolecular recognition site; other site 226900012937 dimerization interface [polypeptide binding]; other site 226900012938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900012939 DNA binding site [nucleotide binding] 226900012940 similar to O-succinylbenzoate-CoA synthase 226900012941 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 226900012942 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 226900012943 acyl-activating enzyme (AAE) consensus motif; other site 226900012944 putative AMP binding site [chemical binding]; other site 226900012945 putative active site [active] 226900012946 putative CoA binding site [chemical binding]; other site 226900012947 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 226900012948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900012949 substrate binding site [chemical binding]; other site 226900012950 oxyanion hole (OAH) forming residues; other site 226900012951 trimer interface [polypeptide binding]; other site 226900012952 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 226900012953 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900012954 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 226900012955 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 226900012956 dimer interface [polypeptide binding]; other site 226900012957 tetramer interface [polypeptide binding]; other site 226900012958 PYR/PP interface [polypeptide binding]; other site 226900012959 TPP binding site [chemical binding]; other site 226900012960 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 226900012961 TPP-binding site; other site 226900012962 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 226900012963 chorismate binding enzyme; Region: Chorismate_bind; cl10555 226900012964 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 226900012965 putative active site [active] 226900012966 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 226900012967 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226900012968 DNA-binding site [nucleotide binding]; DNA binding site 226900012969 RNA-binding motif; other site 226900012970 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 226900012971 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 226900012972 active site flap/lid [active] 226900012973 nucleophilic elbow; other site 226900012974 catalytic triad [active] 226900012975 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 226900012976 homodimer interface [polypeptide binding]; other site 226900012977 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 226900012978 active site pocket [active] 226900012979 glycogen synthase; Provisional; Region: glgA; PRK00654 226900012980 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 226900012981 ADP-binding pocket [chemical binding]; other site 226900012982 homodimer interface [polypeptide binding]; other site 226900012983 similar to Glucose-1-phosphate adenylyltransferase; EC_number 2.7.7.27 226900012984 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 226900012985 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 226900012986 ligand binding site; other site 226900012987 oligomer interface; other site 226900012988 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 226900012989 dimer interface [polypeptide binding]; other site 226900012990 N-terminal domain interface [polypeptide binding]; other site 226900012991 sulfate 1 binding site; other site 226900012992 glycogen branching enzyme; Provisional; Region: PRK12313 226900012993 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 226900012994 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 226900012995 active site 226900012996 catalytic site [active] 226900012997 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 226900012998 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 226900012999 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 226900013000 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 226900013001 Subtilase family; Region: Peptidase_S8; pfam00082 226900013002 catalytic triad [active] 226900013003 putative active site [active] 226900013004 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 226900013005 PA/protease domain interface [polypeptide binding]; other site 226900013006 putative integrin binding motif; other site 226900013007 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 226900013008 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 226900013009 dockerin binding interface [polypeptide binding]; other site 226900013010 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 226900013011 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 226900013012 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900013013 NAD binding site [chemical binding]; other site 226900013014 dimer interface [polypeptide binding]; other site 226900013015 substrate binding site [chemical binding]; other site 226900013016 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 226900013017 MgtC family; Region: MgtC; pfam02308 226900013018 similar to Potassium channel protein 226900013019 YugN-like family; Region: YugN; pfam08868 226900013020 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 226900013021 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 226900013022 active site 226900013023 dimer interface [polypeptide binding]; other site 226900013024 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 226900013025 dimer interface [polypeptide binding]; other site 226900013026 active site 226900013027 Domain of unknown function (DUF378); Region: DUF378; pfam04070 226900013028 general stress protein 13; Validated; Region: PRK08059 226900013029 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 226900013030 RNA binding site [nucleotide binding]; other site 226900013031 aspartate aminotransferase; Provisional; Region: PRK05764 226900013032 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900013033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900013034 homodimer interface [polypeptide binding]; other site 226900013035 catalytic residue [active] 226900013036 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900013037 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 226900013038 AsnC family; Region: AsnC_trans_reg; pfam01037 226900013039 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 226900013040 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 226900013041 dimerization interface [polypeptide binding]; other site 226900013042 ligand binding site [chemical binding]; other site 226900013043 NADP binding site [chemical binding]; other site 226900013044 catalytic site [active] 226900013045 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900013046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 226900013047 Putative lysophospholipase; Region: Hydrolase_4; cl19140 226900013048 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 226900013049 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 226900013050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 226900013051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900013052 homodimer interface [polypeptide binding]; other site 226900013053 catalytic residue [active] 226900013054 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 226900013055 E-class dimer interface [polypeptide binding]; other site 226900013056 P-class dimer interface [polypeptide binding]; other site 226900013057 active site 226900013058 Cu2+ binding site [ion binding]; other site 226900013059 Zn2+ binding site [ion binding]; other site 226900013060 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 226900013061 Kinase associated protein B; Region: KapB; pfam08810 226900013062 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 226900013063 active site 226900013064 catalytic site [active] 226900013065 substrate binding site [chemical binding]; other site 226900013066 Citrate transporter; Region: CitMHS; pfam03600 226900013067 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 226900013068 transmembrane helices; other site 226900013069 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 226900013070 active site 226900013071 similar to Glycyl-tRNA synthetase; EC_number 6.1.1.14 226900013072 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 226900013073 CoenzymeA binding site [chemical binding]; other site 226900013074 subunit interaction site [polypeptide binding]; other site 226900013075 PHB binding site; other site 226900013076 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 226900013077 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 226900013078 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 226900013079 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 226900013080 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 226900013081 active site 226900013082 tetramer interface; other site 226900013083 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 226900013084 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 226900013085 active site 226900013086 substrate binding site [chemical binding]; other site 226900013087 metal binding site [ion binding]; metal-binding site 226900013088 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 226900013089 Uncharacterized conserved protein [Function unknown]; Region: COG1624 226900013090 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 226900013091 multifunctional aminopeptidase A; Provisional; Region: PRK00913 226900013092 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 226900013093 interface (dimer of trimers) [polypeptide binding]; other site 226900013094 Substrate-binding/catalytic site; other site 226900013095 Zn-binding sites [ion binding]; other site 226900013096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 226900013097 Putative membrane protein; Region: YuiB; pfam14068 226900013098 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 226900013099 nudix motif; other site 226900013100 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 226900013101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900013102 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 226900013103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900013104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900013105 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013106 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013107 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013108 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013109 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013110 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013111 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013112 conserved repeat domain; Region: B_ant_repeat; TIGR01451 226900013113 Domain of unknown function DUF11; Region: DUF11; pfam01345 226900013114 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013115 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013116 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013117 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013118 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013119 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013120 Domain of unknown function DUF11; Region: DUF11; pfam01345 226900013121 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013122 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013123 Domain of unknown function DUF11; Region: DUF11; pfam01345 226900013124 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 226900013125 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 226900013126 Late cornified envelope-like proline-rich protein 1; Region: LELP1; pfam15042 226900013127 Potato leaf roll virus readthrough protein; Region: PLRV_ORF5; pfam01690 226900013128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 226900013129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900013130 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900013131 putative substrate translocation pore; other site 226900013132 Helix-turn-helix domain; Region: HTH_36; pfam13730 226900013133 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900013134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 226900013135 putative DNA binding site [nucleotide binding]; other site 226900013136 dimerization interface [polypeptide binding]; other site 226900013137 Protein of unknown function (DUF523); Region: DUF523; pfam04463 226900013138 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 226900013139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 226900013140 SmpA / OmlA family; Region: SmpA_OmlA; cl19285 226900013141 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 226900013142 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 226900013143 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 226900013144 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 226900013145 hypothetical protein; Provisional; Region: PRK13669 226900013146 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 226900013147 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900013148 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 226900013149 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900013150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900013151 Walker A/P-loop; other site 226900013152 ATP binding site [chemical binding]; other site 226900013153 Q-loop/lid; other site 226900013154 ABC transporter signature motif; other site 226900013155 Walker B; other site 226900013156 D-loop; other site 226900013157 H-loop/switch region; other site 226900013158 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 226900013159 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 226900013160 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 226900013161 PhnA protein; Region: PhnA; pfam03831 226900013162 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 226900013163 similar to hypothetical protein 226900013164 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 226900013165 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 226900013166 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 226900013167 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 226900013168 active site 226900013169 NTP binding site [chemical binding]; other site 226900013170 metal binding triad [ion binding]; metal-binding site 226900013171 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 226900013172 NifU-like domain; Region: NifU; pfam01106 226900013173 spore coat protein YutH; Region: spore_yutH; TIGR02905 226900013174 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 226900013175 tetramer interfaces [polypeptide binding]; other site 226900013176 binuclear metal-binding site [ion binding]; other site 226900013177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900013178 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900013179 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 226900013180 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 226900013181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900013182 active site 226900013183 motif I; other site 226900013184 motif II; other site 226900013185 Predicted transcriptional regulator [Transcription]; Region: COG2345 226900013186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900013187 putative Zn2+ binding site [ion binding]; other site 226900013188 putative DNA binding site [nucleotide binding]; other site 226900013189 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 226900013190 Uncharacterized conserved protein [Function unknown]; Region: COG2445 226900013191 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 226900013192 putative active site [active] 226900013193 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 226900013194 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 226900013195 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900013196 RNA binding surface [nucleotide binding]; other site 226900013197 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 226900013198 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 226900013199 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900013200 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 226900013201 DNA binding residues [nucleotide binding] 226900013202 dimer interface [polypeptide binding]; other site 226900013203 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 226900013204 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 226900013205 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 226900013206 catalytic core [active] 226900013207 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 226900013208 putative deacylase active site [active] 226900013209 lipoyl synthase; Provisional; Region: PRK05481 226900013210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900013211 FeS/SAM binding site; other site 226900013212 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226900013213 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900013214 sporulation protein YunB; Region: spo_yunB; TIGR02832 226900013215 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 226900013216 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 226900013217 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 226900013218 active site 226900013219 metal binding site [ion binding]; metal-binding site 226900013220 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 226900013221 FeS assembly protein SufB; Region: sufB; TIGR01980 226900013222 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 226900013223 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 226900013224 trimerization site [polypeptide binding]; other site 226900013225 active site 226900013226 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 226900013227 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 226900013228 catalytic residue [active] 226900013229 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 226900013230 FeS assembly protein SufD; Region: sufD; TIGR01981 226900013231 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 226900013232 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 226900013233 Walker A/P-loop; other site 226900013234 ATP binding site [chemical binding]; other site 226900013235 Q-loop/lid; other site 226900013236 ABC transporter signature motif; other site 226900013237 Walker B; other site 226900013238 D-loop; other site 226900013239 H-loop/switch region; other site 226900013240 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 226900013241 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 226900013242 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 226900013243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 226900013244 dimer interface [polypeptide binding]; other site 226900013245 conserved gate region; other site 226900013246 putative PBP binding loops; other site 226900013247 ABC-ATPase subunit interface; other site 226900013248 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 226900013249 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 226900013250 Walker A/P-loop; other site 226900013251 ATP binding site [chemical binding]; other site 226900013252 Q-loop/lid; other site 226900013253 ABC transporter signature motif; other site 226900013254 Walker B; other site 226900013255 D-loop; other site 226900013256 H-loop/switch region; other site 226900013257 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 226900013258 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 226900013259 catalytic residues [active] 226900013260 Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair]; Region: COG1658 226900013261 active site 226900013262 metal binding site [ion binding]; metal-binding site 226900013263 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 226900013264 lipoyl attachment site [posttranslational modification]; other site 226900013265 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 226900013266 putative ArsC-like catalytic residues; other site 226900013267 putative TRX-like catalytic residues [active] 226900013268 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 226900013269 active site 226900013270 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 226900013271 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 226900013272 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 226900013273 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900013274 NAD binding site [chemical binding]; other site 226900013275 dimer interface [polypeptide binding]; other site 226900013276 substrate binding site [chemical binding]; other site 226900013277 Coat F domain; Region: Coat_F; pfam07875 226900013278 CAAX protease self-immunity; Region: Abi; pfam02517 226900013279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900013280 WHG domain; Region: WHG; pfam13305 226900013281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 226900013282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 226900013283 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 226900013284 active site 226900013285 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 226900013286 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 226900013287 dimer interface [polypeptide binding]; other site 226900013288 active site 226900013289 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 226900013290 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 226900013291 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 226900013292 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 226900013293 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 226900013294 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 226900013295 substrate binding site [chemical binding]; other site 226900013296 oxyanion hole (OAH) forming residues; other site 226900013297 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900013298 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900013299 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 226900013300 Proline dehydrogenase; Region: Pro_dh; pfam01619 226900013301 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 226900013302 Domain of unknown function DUF77; Region: DUF77; pfam01910 226900013303 Cache domain; Region: Cache_1; pfam02743 226900013304 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900013305 dimerization interface [polypeptide binding]; other site 226900013306 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226900013307 dimer interface [polypeptide binding]; other site 226900013308 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900013309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 226900013310 dimer interface [polypeptide binding]; other site 226900013311 putative CheW interface [polypeptide binding]; other site 226900013312 Predicted transcriptional regulators [Transcription]; Region: COG1378 226900013313 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 226900013314 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 226900013315 C-terminal domain interface [polypeptide binding]; other site 226900013316 sugar binding site [chemical binding]; other site 226900013317 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226900013318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900013319 putative substrate translocation pore; other site 226900013320 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 226900013321 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 226900013322 MAEBL; Provisional; Region: PTZ00121 226900013323 OxaA-like protein precursor; Validated; Region: PRK01622 226900013324 Uncharacterized conserved protein [Function unknown]; Region: COG1284 226900013325 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900013326 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900013327 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 226900013328 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 226900013329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900013330 hypothetical protein; Provisional; Region: PRK06758 226900013331 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 226900013332 active site 226900013333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900013334 salt bridge; other site 226900013335 non-specific DNA binding site [nucleotide binding]; other site 226900013336 sequence-specific DNA binding site [nucleotide binding]; other site 226900013337 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 226900013338 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 226900013339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 226900013340 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 226900013341 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900013342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900013343 active site 226900013344 phosphorylation site [posttranslational modification] 226900013345 intermolecular recognition site; other site 226900013346 dimerization interface [polypeptide binding]; other site 226900013347 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900013348 DNA binding site [nucleotide binding] 226900013349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 226900013350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900013351 dimer interface [polypeptide binding]; other site 226900013352 phosphorylation site [posttranslational modification] 226900013353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900013354 ATP binding site [chemical binding]; other site 226900013355 Mg2+ binding site [ion binding]; other site 226900013356 G-X-G motif; other site 226900013357 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 226900013358 EamA-like transporter family; Region: EamA; pfam00892 226900013359 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 226900013360 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 226900013361 active site 226900013362 HIGH motif; other site 226900013363 KMSKS motif; other site 226900013364 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 226900013365 tRNA binding surface [nucleotide binding]; other site 226900013366 anticodon binding site; other site 226900013367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900013368 S-adenosylmethionine binding site [chemical binding]; other site 226900013369 similar to Methyl-accepting chemotaxis protein 226900013370 CHASE3 domain; Region: CHASE3; cl05000 226900013371 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 226900013372 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900013373 dimerization interface [polypeptide binding]; other site 226900013374 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226900013375 dimer interface [polypeptide binding]; other site 226900013376 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 226900013377 dimer interface [polypeptide binding]; other site 226900013378 putative CheW interface [polypeptide binding]; other site 226900013379 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 226900013380 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900013381 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900013382 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 226900013383 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900013384 active site 226900013385 Zn binding site [ion binding]; other site 226900013386 Pirin-related protein [General function prediction only]; Region: COG1741 226900013387 Pirin; Region: Pirin; pfam02678 226900013388 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 226900013389 Transcriptional regulators [Transcription]; Region: MarR; COG1846 226900013390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 226900013391 putative Zn2+ binding site [ion binding]; other site 226900013392 putative DNA binding site [nucleotide binding]; other site 226900013393 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 226900013394 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 226900013395 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 226900013396 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 226900013397 TrkA-C domain; Region: TrkA_C; pfam02080 226900013398 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 226900013399 Ferritin-like domain; Region: Ferritin; pfam00210 226900013400 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 226900013401 dimerization interface [polypeptide binding]; other site 226900013402 DPS ferroxidase diiron center [ion binding]; other site 226900013403 ion pore; other site 226900013404 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 226900013405 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 226900013406 metal binding site [ion binding]; metal-binding site 226900013407 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 226900013408 Ferritin-like domain; Region: Ferritin; pfam00210 226900013409 ferroxidase diiron center [ion binding]; other site 226900013410 Predicted membrane protein [Function unknown]; Region: COG2311 226900013411 Protein of unknown function (DUF418); Region: DUF418; pfam04235 226900013412 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900013413 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900013414 Nucleoside recognition; Region: Gate; pfam07670 226900013415 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900013416 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 226900013417 similar to Sodium/proton-dependent alanine carrier protein 226900013418 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 226900013419 NAD binding site [chemical binding]; other site 226900013420 substrate binding site [chemical binding]; other site 226900013421 putative active site [active] 226900013422 Peptidase M60-like family; Region: M60-like; pfam13402 226900013423 Peptidase M60-like family; Region: M60-like; cl19940 226900013424 TQXA domain; Region: TQXA_dom; TIGR03934 226900013425 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 226900013426 active site 226900013427 catalytic tetrad [active] 226900013428 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 226900013429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900013430 putative substrate translocation pore; other site 226900013431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900013432 dimerization interface [polypeptide binding]; other site 226900013433 putative DNA binding site [nucleotide binding]; other site 226900013434 putative Zn2+ binding site [ion binding]; other site 226900013435 Uncharacterized conserved protein [Function unknown]; Region: COG2427 226900013436 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 226900013437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900013438 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 226900013439 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 226900013440 active site 226900013441 HIGH motif; other site 226900013442 dimer interface [polypeptide binding]; other site 226900013443 KMSKS motif; other site 226900013444 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 226900013445 RNA binding surface [nucleotide binding]; other site 226900013446 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 226900013447 FAD binding domain; Region: FAD_binding_4; pfam01565 226900013448 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 226900013449 SET domain; Region: SET; pfam00856 226900013450 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 226900013451 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 226900013452 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226900013453 dimer interface [polypeptide binding]; other site 226900013454 putative CheW interface [polypeptide binding]; other site 226900013455 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 226900013456 putative catalytic site [active] 226900013457 putative metal binding site [ion binding]; other site 226900013458 putative phosphate binding site [ion binding]; other site 226900013459 camphor resistance protein CrcB; Provisional; Region: PRK14219 226900013460 camphor resistance protein CrcB; Provisional; Region: PRK14205 226900013461 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 226900013462 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 226900013463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900013464 H+ Antiporter protein; Region: 2A0121; TIGR00900 226900013465 putative substrate translocation pore; other site 226900013466 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900013467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900013468 ABC transporter; Region: ABC_tran_2; pfam12848 226900013469 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900013470 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 226900013471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 226900013472 Coenzyme A binding pocket [chemical binding]; other site 226900013473 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 226900013474 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900013475 DNA binding residues [nucleotide binding] 226900013476 dimer interface [polypeptide binding]; other site 226900013477 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 226900013478 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 226900013479 23S rRNA interface [nucleotide binding]; other site 226900013480 L7/L12 interface [polypeptide binding]; other site 226900013481 putative thiostrepton binding site; other site 226900013482 L25 interface [polypeptide binding]; other site 226900013483 short chain dehydrogenase; Region: adh_short; pfam00106 226900013484 classical (c) SDRs; Region: SDR_c; cd05233 226900013485 NAD(P) binding site [chemical binding]; other site 226900013486 active site 226900013487 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 226900013488 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 226900013489 23S rRNA interface [nucleotide binding]; other site 226900013490 L7/L12 interface [polypeptide binding]; other site 226900013491 putative thiostrepton binding site; other site 226900013492 L25 interface [polypeptide binding]; other site 226900013493 short chain dehydrogenase; Provisional; Region: PRK06841 226900013494 classical (c) SDRs; Region: SDR_c; cd05233 226900013495 NAD(P) binding site [chemical binding]; other site 226900013496 active site 226900013497 tocopherol O-methyltransferase; Region: PLN02244 226900013498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900013499 S-adenosylmethionine binding site [chemical binding]; other site 226900013500 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 226900013501 NADPH bind site [chemical binding]; other site 226900013502 putative FMN binding site [chemical binding]; other site 226900013503 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 226900013504 SpaB C-terminal domain; Region: SpaB_C; pfam14028 226900013505 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 226900013506 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 226900013507 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 226900013508 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 226900013509 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 226900013510 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 226900013511 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 226900013512 thiazolylpeptide-type bacteriocin precursor; Region: thiopep_precurs; TIGR03892 226900013513 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 226900013514 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 226900013515 active site 226900013516 metal binding site [ion binding]; metal-binding site 226900013517 putative uracil/xanthine transporter; Provisional; Region: PRK11412 226900013518 HTH-like domain; Region: HTH_21; pfam13276 226900013519 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 226900013520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900013521 putative DNA binding site [nucleotide binding]; other site 226900013522 putative Zn2+ binding site [ion binding]; other site 226900013523 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 226900013524 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 226900013525 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 226900013526 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900013527 Walker A/P-loop; other site 226900013528 ATP binding site [chemical binding]; other site 226900013529 Q-loop/lid; other site 226900013530 ABC transporter signature motif; other site 226900013531 Walker B; other site 226900013532 D-loop; other site 226900013533 H-loop/switch region; other site 226900013534 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900013535 ABC-ATPase subunit interface; other site 226900013536 dimer interface [polypeptide binding]; other site 226900013537 putative PBP binding regions; other site 226900013538 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900013539 ABC-ATPase subunit interface; other site 226900013540 dimer interface [polypeptide binding]; other site 226900013541 putative PBP binding regions; other site 226900013542 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 226900013543 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 226900013544 putative ligand binding residues [chemical binding]; other site 226900013545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900013546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900013547 active site 226900013548 phosphorylation site [posttranslational modification] 226900013549 intermolecular recognition site; other site 226900013550 dimerization interface [polypeptide binding]; other site 226900013551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900013552 DNA binding site [nucleotide binding] 226900013553 TniQ; Region: TniQ; pfam06527 226900013554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900013555 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226900013556 AAA domain; Region: AAA_17; pfam13207 226900013557 Walker A motif; other site 226900013558 ATP binding site [chemical binding]; other site 226900013559 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 226900013560 Integrase core domain; Region: rve; pfam00665 226900013561 TniQ; Region: TniQ; pfam06527 226900013562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900013563 sequence-specific DNA binding site [nucleotide binding]; other site 226900013564 salt bridge; other site 226900013565 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 226900013566 DDE domain; Region: DDE_Tnp_IS240; pfam13610 226900013567 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 226900013568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900013569 Walker A/P-loop; other site 226900013570 ATP binding site [chemical binding]; other site 226900013571 Q-loop/lid; other site 226900013572 ABC transporter signature motif; other site 226900013573 Walker B; other site 226900013574 D-loop; other site 226900013575 H-loop/switch region; other site 226900013576 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 226900013577 FMN binding site [chemical binding]; other site 226900013578 dimer interface [polypeptide binding]; other site 226900013579 YcaO-like family; Region: YcaO; pfam02624 226900013580 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 226900013581 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 226900013582 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 226900013583 active site 226900013584 putative substrate binding region [chemical binding]; other site 226900013585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 226900013586 DDE domain; Region: DDE_Tnp_IS240; pfam13610 226900013587 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 226900013588 SmpB-tmRNA interface; other site 226900013589 ribonuclease R; Region: RNase_R; TIGR02063 226900013590 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 226900013591 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 226900013592 RNB domain; Region: RNB; pfam00773 226900013593 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 226900013594 RNA binding site [nucleotide binding]; other site 226900013595 Esterase/lipase [General function prediction only]; Region: COG1647 226900013596 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 226900013597 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 226900013598 holin-like protein; Validated; Region: PRK01658 226900013599 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 226900013600 active site 226900013601 enolase; Provisional; Region: eno; PRK00077 226900013602 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 226900013603 dimer interface [polypeptide binding]; other site 226900013604 metal binding site [ion binding]; metal-binding site 226900013605 substrate binding pocket [chemical binding]; other site 226900013606 phosphoglyceromutase; Provisional; Region: PRK05434 226900013607 similar to Triosephosphate isomerase; EC_number 5.3.1.1 226900013608 similar to Phosphoglycerate kinase; EC_number 2.7.2.3 226900013609 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 226900013610 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 226900013611 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 226900013612 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 226900013613 Predicted transcriptional regulator [Transcription]; Region: COG3388 226900013614 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 226900013615 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 226900013616 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 226900013617 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 226900013618 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 226900013619 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 226900013620 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 226900013621 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 226900013622 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 226900013623 stage V sporulation protein AD; Provisional; Region: PRK12404 226900013624 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 226900013625 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 226900013626 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 226900013627 Predicted membrane protein [Function unknown]; Region: COG2323 226900013628 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 226900013629 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 226900013630 oligomer interface [polypeptide binding]; other site 226900013631 active site residues [active] 226900013632 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 226900013633 dimerization domain swap beta strand [polypeptide binding]; other site 226900013634 regulatory protein interface [polypeptide binding]; other site 226900013635 active site 226900013636 regulatory phosphorylation site [posttranslational modification]; other site 226900013637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 226900013638 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 226900013639 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 226900013640 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 226900013641 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 226900013642 phosphate binding site [ion binding]; other site 226900013643 putative substrate binding pocket [chemical binding]; other site 226900013644 dimer interface [polypeptide binding]; other site 226900013645 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 226900013646 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 226900013647 putative active site [active] 226900013648 nucleotide binding site [chemical binding]; other site 226900013649 nudix motif; other site 226900013650 putative metal binding site [ion binding]; other site 226900013651 Domain of unknown function (DUF368); Region: DUF368; pfam04018 226900013652 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 226900013653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 226900013654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 226900013655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900013656 binding surface 226900013657 TPR motif; other site 226900013658 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900013659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 226900013660 binding surface 226900013661 Tetratricopeptide repeat; Region: TPR_16; pfam13432 226900013662 TPR motif; other site 226900013663 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 226900013664 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 226900013665 trimer interface [polypeptide binding]; other site 226900013666 active site 226900013667 substrate binding site [chemical binding]; other site 226900013668 CoA binding site [chemical binding]; other site 226900013669 pyrophosphatase PpaX; Provisional; Region: PRK13288 226900013670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900013671 active site 226900013672 motif I; other site 226900013673 motif II; other site 226900013674 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 226900013675 HPr kinase/phosphorylase; Provisional; Region: PRK05428 226900013676 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 226900013677 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 226900013678 Hpr binding site; other site 226900013679 active site 226900013680 homohexamer subunit interaction site [polypeptide binding]; other site 226900013681 Predicted membrane protein [Function unknown]; Region: COG1950 226900013682 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 226900013683 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 226900013684 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 226900013685 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 226900013686 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 226900013687 excinuclease ABC subunit B; Provisional; Region: PRK05298 226900013688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900013689 ATP binding site [chemical binding]; other site 226900013690 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900013691 nucleotide binding region [chemical binding]; other site 226900013692 ATP-binding site [chemical binding]; other site 226900013693 Ultra-violet resistance protein B; Region: UvrB; pfam12344 226900013694 UvrB/uvrC motif; Region: UVR; pfam02151 226900013695 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 226900013696 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 226900013697 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900013698 DNA binding residues [nucleotide binding] 226900013699 dimer interface [polypeptide binding]; other site 226900013700 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 226900013701 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900013702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900013703 non-specific DNA binding site [nucleotide binding]; other site 226900013704 salt bridge; other site 226900013705 sequence-specific DNA binding site [nucleotide binding]; other site 226900013706 Predicted membrane protein [Function unknown]; Region: COG2855 226900013707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900013708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900013709 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 226900013710 putative dimerization interface [polypeptide binding]; other site 226900013711 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900013712 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 226900013713 DNA binding residues [nucleotide binding] 226900013714 putative dimer interface [polypeptide binding]; other site 226900013715 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 226900013716 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900013717 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900013718 ABC transporter; Region: ABC_tran_2; pfam12848 226900013719 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900013720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 226900013721 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900013722 Helix-turn-helix domain; Region: HTH_28; pfam13518 226900013723 Herpesvirus BLRF2 protein; Region: Herpes_BLRF2; pfam05812 226900013724 putative transposase OrfB; Reviewed; Region: PHA02517 226900013725 HTH-like domain; Region: HTH_21; pfam13276 226900013726 Integrase core domain; Region: rve; pfam00665 226900013727 Integrase core domain; Region: rve_2; pfam13333 226900013728 hypothetical protein; Provisional; Region: PRK12855 226900013729 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 226900013730 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 226900013731 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 226900013732 Walker A/P-loop; other site 226900013733 ATP binding site [chemical binding]; other site 226900013734 Q-loop/lid; other site 226900013735 ABC transporter signature motif; other site 226900013736 Walker B; other site 226900013737 D-loop; other site 226900013738 H-loop/switch region; other site 226900013739 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 226900013740 protein binding site [polypeptide binding]; other site 226900013741 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 226900013742 C-terminal peptidase (prc); Region: prc; TIGR00225 226900013743 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 226900013744 protein binding site [polypeptide binding]; other site 226900013745 Catalytic dyad [active] 226900013746 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 226900013747 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 226900013748 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 226900013749 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 226900013750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900013751 Walker A/P-loop; other site 226900013752 ATP binding site [chemical binding]; other site 226900013753 Q-loop/lid; other site 226900013754 ABC transporter signature motif; other site 226900013755 Walker B; other site 226900013756 D-loop; other site 226900013757 H-loop/switch region; other site 226900013758 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 226900013759 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 226900013760 peptide chain release factor 2; Provisional; Region: PRK06746 226900013761 This domain is found in peptide chain release factors; Region: PCRF; smart00937 226900013762 RF-1 domain; Region: RF-1; pfam00472 226900013763 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 226900013764 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 226900013765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900013766 nucleotide binding region [chemical binding]; other site 226900013767 ATP-binding site [chemical binding]; other site 226900013768 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 226900013769 SEC-C motif; Region: SEC-C; cl19389 226900013770 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 226900013771 30S subunit binding site; other site 226900013772 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 226900013773 DNA-binding site [nucleotide binding]; DNA binding site 226900013774 RNA-binding motif; other site 226900013775 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 226900013776 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900013777 active site 226900013778 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 226900013779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900013780 ATP binding site [chemical binding]; other site 226900013781 putative Mg++ binding site [ion binding]; other site 226900013782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900013783 nucleotide binding region [chemical binding]; other site 226900013784 ATP-binding site [chemical binding]; other site 226900013785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 226900013786 Probable transposase; Region: OrfB_IS605; pfam01385 226900013787 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 226900013788 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 226900013789 Transposase IS200 like; Region: Y1_Tnp; pfam01797 226900013790 Sperm tail; Region: NYD-SP28; pfam14772 226900013791 CBP4; Region: CBP4; pfam07960 226900013792 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 226900013793 NlpC/P60 family; Region: NLPC_P60; pfam00877 226900013794 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 226900013795 dimerization interface [polypeptide binding]; other site 226900013796 putative DNA binding site [nucleotide binding]; other site 226900013797 putative Zn2+ binding site [ion binding]; other site 226900013798 EDD domain protein, DegV family; Region: DegV; TIGR00762 226900013799 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 226900013800 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 226900013801 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 226900013802 Transcriptional regulator [Transcription]; Region: LytR; COG1316 226900013803 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 226900013804 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 226900013805 active site 226900013806 homodimer interface [polypeptide binding]; other site 226900013807 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 226900013808 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 226900013809 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 226900013810 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 226900013811 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 226900013812 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 226900013813 Mg++ binding site [ion binding]; other site 226900013814 putative catalytic motif [active] 226900013815 substrate binding site [chemical binding]; other site 226900013816 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 226900013817 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 226900013818 NodB motif; other site 226900013819 active site 226900013820 catalytic site [active] 226900013821 Zn binding site [ion binding]; other site 226900013822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 226900013823 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 226900013824 Walker A motif; other site 226900013825 ATP binding site [chemical binding]; other site 226900013826 Walker B motif; other site 226900013827 arginine finger; other site 226900013828 Transcriptional antiterminator [Transcription]; Region: COG3933 226900013829 PRD domain; Region: PRD; pfam00874 226900013830 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 226900013831 active pocket/dimerization site; other site 226900013832 active site 226900013833 phosphorylation site [posttranslational modification] 226900013834 PRD domain; Region: PRD; pfam00874 226900013835 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 226900013836 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 226900013837 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 226900013838 Chromate transporter; Region: Chromate_transp; pfam02417 226900013839 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 226900013840 putative active site [active] 226900013841 YdjC motif; other site 226900013842 Mg binding site [ion binding]; other site 226900013843 putative homodimer interface [polypeptide binding]; other site 226900013844 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 226900013845 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 226900013846 NAD binding site [chemical binding]; other site 226900013847 sugar binding site [chemical binding]; other site 226900013848 divalent metal binding site [ion binding]; other site 226900013849 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900013850 dimer interface [polypeptide binding]; other site 226900013851 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 226900013852 active site 226900013853 methionine cluster; other site 226900013854 phosphorylation site [posttranslational modification] 226900013855 metal binding site [ion binding]; metal-binding site 226900013856 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 226900013857 similar to PTS system, lichenan oligosaccharide-specific IIB component; EC_number 2.7.1.69 226900013858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900013859 S-adenosylmethionine binding site [chemical binding]; other site 226900013860 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 226900013861 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 226900013862 methionine cluster; other site 226900013863 active site 226900013864 phosphorylation site [posttranslational modification] 226900013865 metal binding site [ion binding]; metal-binding site 226900013866 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 226900013867 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 226900013868 active site 226900013869 P-loop; other site 226900013870 phosphorylation site [posttranslational modification] 226900013871 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 226900013872 Acyltransferase family; Region: Acyl_transf_3; pfam01757 226900013873 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 226900013874 Predicted membrane protein [Function unknown]; Region: COG1511 226900013875 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 226900013876 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 226900013877 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 226900013878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 226900013879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 226900013880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 226900013881 dimerization interface [polypeptide binding]; other site 226900013882 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 226900013883 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 226900013884 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 226900013885 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 226900013886 transmembrane helices; other site 226900013887 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 226900013888 ThiC-associated domain; Region: ThiC-associated; pfam13667 226900013889 ThiC family; Region: ThiC; pfam01964 226900013890 L-lactate permease; Region: Lactate_perm; cl00701 226900013891 Tic20-like protein; Region: Tic20; pfam09685 226900013892 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 226900013893 Uncharacterized conserved protein [Function unknown]; Region: COG3339 226900013894 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 226900013895 Sulfatase; Region: Sulfatase; pfam00884 226900013896 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 226900013897 homodimer interface [polypeptide binding]; other site 226900013898 substrate-cofactor binding pocket; other site 226900013899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900013900 catalytic residue [active] 226900013901 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900013902 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 226900013903 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900013904 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900013905 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900013906 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 226900013907 NlpC/P60 family; Region: NLPC_P60; pfam00877 226900013908 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 226900013909 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 226900013910 Nucleoside recognition; Region: Gate; pfam07670 226900013911 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 226900013912 rod shape-determining protein MreC; Region: MreC; cl19252 226900013913 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 226900013914 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 226900013915 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 226900013916 DXD motif; other site 226900013917 BCCT family transporter; Region: BCCT; pfam02028 226900013918 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900013919 Bacterial SH3 domain; Region: SH3_3; pfam08239 226900013920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 226900013921 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 226900013922 Predicted membrane protein [Function unknown]; Region: COG4640 226900013923 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 226900013924 Double zinc ribbon; Region: DZR; pfam12773 226900013925 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 226900013926 Double zinc ribbon; Region: DZR; pfam12773 226900013927 Uncharacterized conserved protein [Function unknown]; Region: COG4715 226900013928 SNF2 Helicase protein; Region: DUF3670; pfam12419 226900013929 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 226900013930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 226900013931 ATP binding site [chemical binding]; other site 226900013932 putative Mg++ binding site [ion binding]; other site 226900013933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900013934 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 226900013935 nucleotide binding region [chemical binding]; other site 226900013936 ATP-binding site [chemical binding]; other site 226900013937 Predicted integral membrane protein [Function unknown]; Region: COG5652 226900013938 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 226900013939 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 226900013940 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 226900013941 ComK protein; Region: ComK; cl11560 226900013942 RNA polymerase factor sigma-70; Validated; Region: PRK06759 226900013943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900013944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 226900013945 DNA binding residues [nucleotide binding] 226900013946 Yip1 domain; Region: Yip1; cl17815 226900013947 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 226900013948 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 226900013949 FtsX-like permease family; Region: FtsX; pfam02687 226900013950 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 226900013951 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 226900013952 Walker A/P-loop; other site 226900013953 ATP binding site [chemical binding]; other site 226900013954 Q-loop/lid; other site 226900013955 ABC transporter signature motif; other site 226900013956 Walker B; other site 226900013957 D-loop; other site 226900013958 H-loop/switch region; other site 226900013959 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 226900013960 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 226900013961 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 226900013962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900013963 non-specific DNA binding site [nucleotide binding]; other site 226900013964 salt bridge; other site 226900013965 sequence-specific DNA binding site [nucleotide binding]; other site 226900013966 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 226900013967 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 226900013968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900013969 putative substrate translocation pore; other site 226900013970 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 226900013971 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 226900013972 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 226900013973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900013974 dimerization interface [polypeptide binding]; other site 226900013975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900013976 dimer interface [polypeptide binding]; other site 226900013977 phosphorylation site [posttranslational modification] 226900013978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900013979 ATP binding site [chemical binding]; other site 226900013980 Mg2+ binding site [ion binding]; other site 226900013981 G-X-G motif; other site 226900013982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900013983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900013984 active site 226900013985 phosphorylation site [posttranslational modification] 226900013986 intermolecular recognition site; other site 226900013987 dimerization interface [polypeptide binding]; other site 226900013988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900013989 DNA binding site [nucleotide binding] 226900013990 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 226900013991 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 226900013992 NAD binding site [chemical binding]; other site 226900013993 homodimer interface [polypeptide binding]; other site 226900013994 active site 226900013995 substrate binding site [chemical binding]; other site 226900013996 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 226900013997 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 226900013998 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226900013999 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226900014000 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900014001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226900014002 active site 226900014003 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 226900014004 This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946 226900014005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226900014006 Bacterial sugar transferase; Region: Bac_transf; pfam02397 226900014007 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 226900014008 extended (e) SDRs; Region: SDR_e; cd08946 226900014009 NAD(P) binding site [chemical binding]; other site 226900014010 active site 226900014011 substrate binding site [chemical binding]; other site 226900014012 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 226900014013 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 226900014014 inhibitor-cofactor binding pocket; inhibition site 226900014015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900014016 catalytic residue [active] 226900014017 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 226900014018 CoA-binding domain; Region: CoA_binding_3; pfam13727 226900014019 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 226900014020 NAD(P) binding site [chemical binding]; other site 226900014021 homodimer interface [polypeptide binding]; other site 226900014022 substrate binding site [chemical binding]; other site 226900014023 active site 226900014024 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 226900014025 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 226900014026 active site 226900014027 tetramer interface; other site 226900014028 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 226900014029 PHP domain; Region: PHP; pfam02811 226900014030 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 226900014031 AAA domain; Region: AAA_31; pfam13614 226900014032 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 226900014033 Chain length determinant protein; Region: Wzz; pfam02706 226900014034 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 226900014035 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 226900014036 AAA domain; Region: AAA_31; pfam13614 226900014037 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 226900014038 rod shape-determining protein Mbl; Provisional; Region: PRK13928 226900014039 MreB and similar proteins; Region: MreB_like; cd10225 226900014040 nucleotide binding site [chemical binding]; other site 226900014041 Mg binding site [ion binding]; other site 226900014042 putative protofilament interaction site [polypeptide binding]; other site 226900014043 RodZ interaction site [polypeptide binding]; other site 226900014044 Stage III sporulation protein D; Region: SpoIIID; cl17560 226900014045 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 226900014046 Peptidase family M23; Region: Peptidase_M23; pfam01551 226900014047 CcmB protein; Region: CcmB; cl17444 226900014048 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226900014049 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900014050 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900014051 Walker A/P-loop; other site 226900014052 ATP binding site [chemical binding]; other site 226900014053 Q-loop/lid; other site 226900014054 ABC transporter signature motif; other site 226900014055 Walker B; other site 226900014056 D-loop; other site 226900014057 H-loop/switch region; other site 226900014058 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 226900014059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 226900014060 Q-loop/lid; other site 226900014061 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226900014062 ABC transporter signature motif; other site 226900014063 Walker B; other site 226900014064 D-loop; other site 226900014065 H-loop/switch region; other site 226900014066 LytTr DNA-binding domain; Region: LytTR; pfam04397 226900014067 stage II sporulation protein D; Region: spore_II_D; TIGR02870 226900014068 Stage II sporulation protein; Region: SpoIID; pfam08486 226900014069 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 226900014070 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 226900014071 hinge; other site 226900014072 active site 226900014073 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 226900014074 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 226900014075 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 226900014076 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 226900014077 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 226900014078 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 226900014079 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 226900014080 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 226900014081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 226900014082 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 226900014083 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 226900014084 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 226900014085 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 226900014086 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 226900014087 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 226900014088 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 226900014089 NADH dehydrogenase subunit C; Validated; Region: PRK07735 226900014090 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 226900014091 NADH dehydrogenase subunit B; Validated; Region: PRK06411 226900014092 NADH dehydrogenase subunit A; Validated; Region: PRK07756 226900014093 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 226900014094 PAS domain; Region: PAS_9; pfam13426 226900014095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900014096 putative active site [active] 226900014097 heme pocket [chemical binding]; other site 226900014098 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900014099 metal binding site [ion binding]; metal-binding site 226900014100 active site 226900014101 I-site; other site 226900014102 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 226900014103 Protein of unknown function (DUF975); Region: DUF975; cl10504 226900014104 similar to Integral membrane protein 226900014105 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 226900014106 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 226900014107 gamma subunit interface [polypeptide binding]; other site 226900014108 epsilon subunit interface [polypeptide binding]; other site 226900014109 LBP interface [polypeptide binding]; other site 226900014110 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 226900014111 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226900014112 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 226900014113 alpha subunit interaction interface [polypeptide binding]; other site 226900014114 Walker A motif; other site 226900014115 ATP binding site [chemical binding]; other site 226900014116 Walker B motif; other site 226900014117 inhibitor binding site; inhibition site 226900014118 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226900014119 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 226900014120 core domain interface [polypeptide binding]; other site 226900014121 delta subunit interface [polypeptide binding]; other site 226900014122 epsilon subunit interface [polypeptide binding]; other site 226900014123 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 226900014124 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 226900014125 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 226900014126 beta subunit interaction interface [polypeptide binding]; other site 226900014127 Walker A motif; other site 226900014128 ATP binding site [chemical binding]; other site 226900014129 Walker B motif; other site 226900014130 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 226900014131 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 226900014132 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 226900014133 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 226900014134 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 226900014135 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 226900014136 ATP synthase I chain; Region: ATP_synt_I; pfam03899 226900014137 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 226900014138 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 226900014139 active site 226900014140 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 226900014141 dimer interface [polypeptide binding]; other site 226900014142 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 226900014143 active site 226900014144 glycine-pyridoxal phosphate binding site [chemical binding]; other site 226900014145 folate binding site [chemical binding]; other site 226900014146 hypothetical protein; Provisional; Region: PRK13690 226900014147 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 226900014148 Low molecular weight phosphatase family; Region: LMWPc; cd00115 226900014149 active site 226900014150 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 226900014151 HPr interaction site; other site 226900014152 glycerol kinase (GK) interaction site [polypeptide binding]; other site 226900014153 active site 226900014154 phosphorylation site [posttranslational modification] 226900014155 Predicted membrane protein [Function unknown]; Region: COG2259 226900014156 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 226900014157 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 226900014158 Predicted membrane protein [Function unknown]; Region: COG1971 226900014159 Domain of unknown function DUF; Region: DUF204; pfam02659 226900014160 Domain of unknown function DUF; Region: DUF204; pfam02659 226900014161 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 226900014162 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 226900014163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 226900014164 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 226900014165 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 226900014166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900014167 S-adenosylmethionine binding site [chemical binding]; other site 226900014168 peptide chain release factor 1; Validated; Region: prfA; PRK00591 226900014169 This domain is found in peptide chain release factors; Region: PCRF; smart00937 226900014170 RF-1 domain; Region: RF-1; pfam00472 226900014171 thymidine kinase; Provisional; Region: PRK04296 226900014172 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 226900014173 transcription termination factor Rho; Provisional; Region: rho; PRK09376 226900014174 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 226900014175 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 226900014176 RNA binding site [nucleotide binding]; other site 226900014177 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 226900014178 multimer interface [polypeptide binding]; other site 226900014179 Walker A motif; other site 226900014180 ATP binding site [chemical binding]; other site 226900014181 Walker B motif; other site 226900014182 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 226900014183 putative active site [active] 226900014184 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 226900014185 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 226900014186 hinge; other site 226900014187 active site 226900014188 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 226900014189 intersubunit interface [polypeptide binding]; other site 226900014190 active site 226900014191 zinc binding site [ion binding]; other site 226900014192 Na+ binding site [ion binding]; other site 226900014193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900014194 active site 226900014195 phosphorylation site [posttranslational modification] 226900014196 intermolecular recognition site; other site 226900014197 dimerization interface [polypeptide binding]; other site 226900014198 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 226900014199 CTP synthetase; Validated; Region: pyrG; PRK05380 226900014200 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 226900014201 Catalytic site [active] 226900014202 active site 226900014203 UTP binding site [chemical binding]; other site 226900014204 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 226900014205 active site 226900014206 putative oxyanion hole; other site 226900014207 catalytic triad [active] 226900014208 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 226900014209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900014210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900014211 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 226900014212 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 226900014213 FAD binding site [chemical binding]; other site 226900014214 homotetramer interface [polypeptide binding]; other site 226900014215 substrate binding pocket [chemical binding]; other site 226900014216 catalytic base [active] 226900014217 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 226900014218 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 226900014219 FAD binding site [chemical binding]; other site 226900014220 homotetramer interface [polypeptide binding]; other site 226900014221 substrate binding pocket [chemical binding]; other site 226900014222 catalytic base [active] 226900014223 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 226900014224 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 226900014225 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 226900014226 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 226900014227 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 226900014228 dimer interface [polypeptide binding]; other site 226900014229 active site 226900014230 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 226900014231 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 226900014232 Cysteine-rich domain; Region: CCG; pfam02754 226900014233 Cysteine-rich domain; Region: CCG; pfam02754 226900014234 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 226900014235 PLD-like domain; Region: PLDc_2; pfam13091 226900014236 putative active site [active] 226900014237 catalytic site [active] 226900014238 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 226900014239 PLD-like domain; Region: PLDc_2; pfam13091 226900014240 putative active site [active] 226900014241 catalytic site [active] 226900014242 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 226900014243 similar to Sensory box/GGDEF family protein 226900014244 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 226900014245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 226900014246 non-specific DNA binding site [nucleotide binding]; other site 226900014247 salt bridge; other site 226900014248 sequence-specific DNA binding site [nucleotide binding]; other site 226900014249 Tetratricopeptide repeat; Region: TPR_12; pfam13424 226900014250 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 226900014251 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 226900014252 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 226900014253 active site 226900014254 Zn binding site [ion binding]; other site 226900014255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900014256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900014257 active site 226900014258 phosphorylation site [posttranslational modification] 226900014259 intermolecular recognition site; other site 226900014260 dimerization interface [polypeptide binding]; other site 226900014261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900014262 DNA binding residues [nucleotide binding] 226900014263 Acyltransferase family; Region: Acyl_transf_3; cl19154 226900014264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900014265 Histidine kinase; Region: HisKA_3; pfam07730 226900014266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900014267 ATP binding site [chemical binding]; other site 226900014268 Mg2+ binding site [ion binding]; other site 226900014269 G-X-G motif; other site 226900014270 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 226900014271 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900014272 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 226900014273 Walker A/P-loop; other site 226900014274 ATP binding site [chemical binding]; other site 226900014275 Q-loop/lid; other site 226900014276 ABC transporter signature motif; other site 226900014277 Walker B; other site 226900014278 D-loop; other site 226900014279 H-loop/switch region; other site 226900014280 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 226900014281 active site 226900014282 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 226900014283 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014284 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014285 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900014286 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014287 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014288 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014289 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014290 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014291 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900014292 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014293 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014294 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014295 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014296 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014297 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014298 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014299 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014300 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 226900014301 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014302 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014303 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014304 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014305 Cna protein B-type domain; Region: Cna_B; pfam05738 226900014306 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 226900014307 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 226900014308 PA/protease or protease-like domain interface [polypeptide binding]; other site 226900014309 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 226900014310 metal binding site [ion binding]; metal-binding site 226900014311 RNA polymerase sigma factor; Provisional; Region: PRK12522 226900014312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 226900014313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 226900014314 DNA binding residues [nucleotide binding] 226900014315 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 226900014316 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 226900014317 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 226900014318 active site 226900014319 HIGH motif; other site 226900014320 KMSK motif region; other site 226900014321 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 226900014322 tRNA binding surface [nucleotide binding]; other site 226900014323 anticodon binding site; other site 226900014324 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 226900014325 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 226900014326 putative dimer interface [polypeptide binding]; other site 226900014327 catalytic triad [active] 226900014328 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 226900014329 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 226900014330 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 226900014331 putative active site [active] 226900014332 Mn binding site [ion binding]; other site 226900014333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900014334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900014335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 226900014336 putative substrate translocation pore; other site 226900014337 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 226900014338 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 226900014339 DNA binding residues [nucleotide binding] 226900014340 putative dimer interface [polypeptide binding]; other site 226900014341 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 226900014342 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 226900014343 active site 226900014344 catalytic site [active] 226900014345 metal binding site [ion binding]; metal-binding site 226900014346 dimer interface [polypeptide binding]; other site 226900014347 Transglycosylase; Region: Transgly; pfam00912 226900014348 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 226900014349 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 226900014350 YwhD family; Region: YwhD; pfam08741 226900014351 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 226900014352 Peptidase family M50; Region: Peptidase_M50; pfam02163 226900014353 active site 226900014354 putative substrate binding region [chemical binding]; other site 226900014355 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 226900014356 active site 1 [active] 226900014357 dimer interface [polypeptide binding]; other site 226900014358 hexamer interface [polypeptide binding]; other site 226900014359 active site 2 [active] 226900014360 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 226900014361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 226900014362 Zn2+ binding site [ion binding]; other site 226900014363 Mg2+ binding site [ion binding]; other site 226900014364 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 226900014365 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 226900014366 intersubunit interface [polypeptide binding]; other site 226900014367 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 226900014368 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 226900014369 Walker A/P-loop; other site 226900014370 ATP binding site [chemical binding]; other site 226900014371 Q-loop/lid; other site 226900014372 ABC transporter signature motif; other site 226900014373 Walker B; other site 226900014374 D-loop; other site 226900014375 H-loop/switch region; other site 226900014376 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900014377 ABC-ATPase subunit interface; other site 226900014378 dimer interface [polypeptide binding]; other site 226900014379 putative PBP binding regions; other site 226900014380 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 226900014381 ABC-ATPase subunit interface; other site 226900014382 dimer interface [polypeptide binding]; other site 226900014383 putative PBP binding regions; other site 226900014384 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 226900014385 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 226900014386 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 226900014387 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 226900014388 putative heme peroxidase; Provisional; Region: PRK12276 226900014389 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 226900014390 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 226900014391 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 226900014392 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 226900014393 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 226900014394 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 226900014395 Protein of unknown function (DUF423); Region: DUF423; pfam04241 226900014396 Ion channel; Region: Ion_trans_2; pfam07885 226900014397 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 226900014398 TrkA-N domain; Region: TrkA_N; pfam02254 226900014399 TrkA-C domain; Region: TrkA_C; pfam02080 226900014400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900014401 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 226900014402 motif II; other site 226900014403 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 226900014404 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 226900014405 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 226900014406 ligand binding site [chemical binding]; other site 226900014407 active site 226900014408 UGI interface [polypeptide binding]; other site 226900014409 catalytic site [active] 226900014410 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 226900014411 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 226900014412 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 226900014413 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 226900014414 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 226900014415 Walker A/P-loop; other site 226900014416 ATP binding site [chemical binding]; other site 226900014417 Q-loop/lid; other site 226900014418 ABC transporter signature motif; other site 226900014419 Walker B; other site 226900014420 D-loop; other site 226900014421 H-loop/switch region; other site 226900014422 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 226900014423 active site 226900014424 catalytic triad [active] 226900014425 oxyanion hole [active] 226900014426 Transcriptional regulators [Transcription]; Region: PurR; COG1609 226900014427 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 226900014428 DNA binding site [nucleotide binding] 226900014429 domain linker motif; other site 226900014430 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 226900014431 putative dimerization interface [polypeptide binding]; other site 226900014432 putative ligand binding site [chemical binding]; other site 226900014433 Predicted membrane protein [Function unknown]; Region: COG2364 226900014434 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 226900014435 homoserine dehydrogenase; Provisional; Region: PRK06349 226900014436 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 226900014437 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 226900014438 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 226900014439 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 226900014440 proposed active site lysine [active] 226900014441 conserved cys residue [active] 226900014442 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 226900014443 homodimer interface [polypeptide binding]; other site 226900014444 substrate-cofactor binding pocket; other site 226900014445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 226900014446 catalytic residue [active] 226900014447 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 226900014448 Cl- selectivity filter; other site 226900014449 Cl- binding residues [ion binding]; other site 226900014450 pore gating glutamate residue; other site 226900014451 dimer interface [polypeptide binding]; other site 226900014452 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 226900014453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 226900014454 motif I; other site 226900014455 motif II; other site 226900014456 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 226900014457 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 226900014458 ligand binding site [chemical binding]; other site 226900014459 flexible hinge region; other site 226900014460 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 226900014461 azoreductase; Provisional; Region: PRK13556 226900014462 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 226900014463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900014464 active site 226900014465 phosphorylation site [posttranslational modification] 226900014466 intermolecular recognition site; other site 226900014467 dimerization interface [polypeptide binding]; other site 226900014468 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 226900014469 DNA binding residues [nucleotide binding] 226900014470 dimerization interface [polypeptide binding]; other site 226900014471 GAF domain; Region: GAF_2; pfam13185 226900014472 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 226900014473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 226900014474 Histidine kinase; Region: HisKA_3; pfam07730 226900014475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900014476 ATP binding site [chemical binding]; other site 226900014477 Mg2+ binding site [ion binding]; other site 226900014478 G-X-G motif; other site 226900014479 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 226900014480 dimer interface [polypeptide binding]; other site 226900014481 substrate binding site [chemical binding]; other site 226900014482 ATP binding site [chemical binding]; other site 226900014483 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 226900014484 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 226900014485 metal binding site [ion binding]; metal-binding site 226900014486 active site 226900014487 I-site; other site 226900014488 Protein of unknown function (DUF466); Region: DUF466; pfam04328 226900014489 carbon starvation protein A; Provisional; Region: PRK15015 226900014490 Carbon starvation protein CstA; Region: CstA; pfam02554 226900014491 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 226900014492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900014493 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226900014494 active site 226900014495 phosphorylation site [posttranslational modification] 226900014496 intermolecular recognition site; other site 226900014497 dimerization interface [polypeptide binding]; other site 226900014498 LytTr DNA-binding domain; Region: LytTR; pfam04397 226900014499 benzoate transport; Region: 2A0115; TIGR00895 226900014500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900014501 putative substrate translocation pore; other site 226900014502 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 226900014503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 226900014504 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 226900014505 Predicted membrane protein [Function unknown]; Region: COG2860 226900014506 UPF0126 domain; Region: UPF0126; pfam03458 226900014507 UPF0126 domain; Region: UPF0126; pfam03458 226900014508 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 226900014509 heme-binding site [chemical binding]; other site 226900014510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 226900014511 dimer interface [polypeptide binding]; other site 226900014512 putative CheW interface [polypeptide binding]; other site 226900014513 conserved hypothetical integral membrane protein; Region: TIGR03766 226900014514 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 226900014515 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 226900014516 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900014517 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 226900014518 Ligand binding site; other site 226900014519 Putative Catalytic site; other site 226900014520 DXD motif; other site 226900014521 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 226900014522 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 226900014523 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 226900014524 active site 226900014525 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 226900014526 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 226900014527 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 226900014528 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 226900014529 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 226900014530 Ligand binding site; other site 226900014531 Putative Catalytic site; other site 226900014532 DXD motif; other site 226900014533 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 226900014534 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900014535 ABC transporter; Region: ABC_tran_2; pfam12848 226900014536 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 226900014537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 226900014538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 226900014539 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 226900014540 G4 box; other site 226900014541 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 226900014542 MMPL family; Region: MMPL; cl14618 226900014543 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 226900014544 MMPL family; Region: MMPL; cl14618 226900014545 methionine sulfoxide reductase A; Provisional; Region: PRK14054 226900014546 methionine sulfoxide reductase B; Provisional; Region: PRK00222 226900014547 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 226900014548 antiholin-like protein LrgB; Provisional; Region: PRK04288 226900014549 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 226900014550 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 226900014551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900014552 active site 226900014553 phosphorylation site [posttranslational modification] 226900014554 intermolecular recognition site; other site 226900014555 dimerization interface [polypeptide binding]; other site 226900014556 LytTr DNA-binding domain; Region: LytTR; pfam04397 226900014557 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 226900014558 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 226900014559 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 226900014560 Histidine kinase; Region: His_kinase; pfam06580 226900014561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900014562 ATP binding site [chemical binding]; other site 226900014563 Mg2+ binding site [ion binding]; other site 226900014564 G-X-G motif; other site 226900014565 benzoate transport; Region: 2A0115; TIGR00895 226900014566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 226900014567 putative substrate translocation pore; other site 226900014568 BCCT family transporter; Region: BCCT; pfam02028 226900014569 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 226900014570 active site 226900014571 dimer interface [polypeptide binding]; other site 226900014572 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 226900014573 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 226900014574 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 226900014575 similar to Isoflavone reductase 226900014576 UreI/AmiS family, subgroup 2. Putative transporters related to proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like_2; cd13429 226900014577 hexamer interface [polypeptide binding]; other site 226900014578 transport channel [chemical binding]; other site 226900014579 constriction site 1 [chemical binding]; other site 226900014580 constriction site 2 [chemical binding]; other site 226900014581 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 226900014582 UDP-glucose 4-epimerase; Region: PLN02240 226900014583 NAD binding site [chemical binding]; other site 226900014584 homodimer interface [polypeptide binding]; other site 226900014585 active site 226900014586 substrate binding site [chemical binding]; other site 226900014587 Haemolysin-III related; Region: HlyIII; cl03831 226900014588 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 226900014589 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 226900014590 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 226900014591 ATP binding site [chemical binding]; other site 226900014592 Mg++ binding site [ion binding]; other site 226900014593 motif III; other site 226900014594 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 226900014595 nucleotide binding region [chemical binding]; other site 226900014596 ATP-binding site [chemical binding]; other site 226900014597 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 226900014598 RNA binding site [nucleotide binding]; other site 226900014599 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 226900014600 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 226900014601 active site 226900014602 oligoendopeptidase F; Region: pepF; TIGR00181 226900014603 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 226900014604 active site 226900014605 Zn binding site [ion binding]; other site 226900014606 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 226900014607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 226900014608 FeS/SAM binding site; other site 226900014609 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 226900014610 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 226900014611 GAF domain; Region: GAF_3; pfam13492 226900014612 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 226900014613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900014614 putative active site [active] 226900014615 heme pocket [chemical binding]; other site 226900014616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900014617 dimer interface [polypeptide binding]; other site 226900014618 phosphorylation site [posttranslational modification] 226900014619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900014620 ATP binding site [chemical binding]; other site 226900014621 Mg2+ binding site [ion binding]; other site 226900014622 G-X-G motif; other site 226900014623 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 226900014624 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 226900014625 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 226900014626 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 226900014627 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 226900014628 protein binding site [polypeptide binding]; other site 226900014629 similar to Zn-dependent hydrolase (beta-lactamase superfamily) 226900014630 YycH protein; Region: YycI; pfam09648 226900014631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 226900014632 YycH protein; Region: YycH; pfam07435 226900014633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 226900014634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 226900014635 dimerization interface [polypeptide binding]; other site 226900014636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 226900014637 putative active site [active] 226900014638 heme pocket [chemical binding]; other site 226900014639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 226900014640 dimer interface [polypeptide binding]; other site 226900014641 phosphorylation site [posttranslational modification] 226900014642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 226900014643 ATP binding site [chemical binding]; other site 226900014644 Mg2+ binding site [ion binding]; other site 226900014645 G-X-G motif; other site 226900014646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 226900014647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 226900014648 active site 226900014649 phosphorylation site [posttranslational modification] 226900014650 intermolecular recognition site; other site 226900014651 dimerization interface [polypeptide binding]; other site 226900014652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 226900014653 DNA binding site [nucleotide binding] 226900014654 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 226900014655 GDP-binding site [chemical binding]; other site 226900014656 ACT binding site; other site 226900014657 IMP binding site; other site 226900014658 similar to Replicative DNA helicase; EC_number 3.6.1.- 226900014659 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 226900014660 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 226900014661 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 226900014662 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 226900014663 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 226900014664 DHH family; Region: DHH; pfam01368 226900014665 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 226900014666 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 226900014667 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 226900014668 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 226900014669 dimer interface [polypeptide binding]; other site 226900014670 ssDNA binding site [nucleotide binding]; other site 226900014671 tetramer (dimer of dimers) interface [polypeptide binding]; other site 226900014672 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 226900014673 GTP-binding protein YchF; Reviewed; Region: PRK09601 226900014674 YchF GTPase; Region: YchF; cd01900 226900014675 G1 box; other site 226900014676 GTP/Mg2+ binding site [chemical binding]; other site 226900014677 Switch I region; other site 226900014678 G2 box; other site 226900014679 Switch II region; other site 226900014680 G3 box; other site 226900014681 G4 box; other site 226900014682 G5 box; other site 226900014683 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 226900014684 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 226900014685 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 226900014686 Mechanosensitive ion channel; Region: MS_channel; pfam00924 226900014687 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 226900014688 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 226900014689 ParB-like nuclease domain; Region: ParB; smart00470 226900014690 KorB domain; Region: KorB; pfam08535 226900014691 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 226900014692 VirC1 protein; Region: VirC1; cl17401 226900014693 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 226900014694 P-loop; other site 226900014695 Magnesium ion binding site [ion binding]; other site 226900014696 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 226900014697 ParB-like nuclease domain; Region: ParBc; pfam02195 226900014698 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 226900014699 Methyltransferase domain; Region: Methyltransf_31; pfam13847 226900014700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 226900014701 S-adenosylmethionine binding site [chemical binding]; other site 226900014702 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 226900014703 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 226900014704 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 226900014705 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 226900014706 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 226900014707 trmE is a tRNA modification GTPase; Region: trmE; cd04164 226900014708 G1 box; other site 226900014709 GTP/Mg2+ binding site [chemical binding]; other site 226900014710 Switch I region; other site 226900014711 G2 box; other site 226900014712 Switch II region; other site 226900014713 G3 box; other site 226900014714 G4 box; other site 226900014715 G5 box; other site 226900014716 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 226900014717 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 226900014718 Jag N-terminus; Region: Jag_N; pfam14804 226900014719 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 226900014720 G-X-X-G motif; other site 226900014721 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 226900014722 RxxxH motif; other site 226900014723 OxaA-like protein precursor; Validated; Region: PRK02944 226900014724 ribonuclease P; Reviewed; Region: rnpA; PRK00499 226900014725 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399